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amyotrofic lateral sclerosis

J Matias-Guiu, R García-Ramos, L Galán, Ja Barcia
INTRODUCTION: The recent failure of the clinical trial of ninocycline outlines if the mechanism of development of the death neuronal in the sporadic amyotrophic lateral sclerosis (SALS) is different to that happens in models of transgenic mice with human mutations related with SOD (TgALS). METHOD: Differences on profile and intensity exist among the oxidative stress mechanisms between TgALS and SALS. Whereas the origin of apoptosis pathway in TgALS comes from the mithocondria and drives to caspase 9 with previous Bid and citocrome C discharge, in SALS, if apoptosis exists, that could proceed through activation of FAS pathway by means of cathepsin B, or alpha-TNF, for microglía activation or from cell cytosol...
October 2008: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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