Chenxi Yang, Ye Yang, Xiuya Hu, Qiqi Tang, Jiaqi Zhang, Peiyu Zhang, Xin Lu, Juan Xu, Sai Li, Zhengni Dong, Lu Zhu, Lingdi Wang
BACKGROUND AND AIMS: Iron overload, oxidative stress and ferroptosis are associated with liver injury in alcohol-associated liver disease (ALD), however, the crosstalk among these regulatory pathways in ALD development is unclear. METHODS: ALD mouse model and general control of amino acid synthesis 5 like 1 (GCN5L1) liver knockout mice were generated to investigate the role of GCN5L1 in ALD development. Proteomic screening tests were performed to identify the key factors mediating GCN5L1 loss-induced ALD...
April 10, 2024: Liver International: Official Journal of the International Association for the Study of the Liver