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minocycline and memory

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https://www.readbyqxmd.com/read/27847283/selective-dentate-gyrus-disruption-causes-memory-impairment-at-the-early-stage-of-experimental-multiple-sclerosis
#1
Vincent Planche, Aude Panatier, Bassem Hiba, Eva-Gunnel Ducourneau, Gerard Raffard, Nadège Dubourdieu, Marlène Maitre, Thierry Lesté-Lasserre, Bruno Brochet, Vincent Dousset, Aline Desmedt, Stéphane H Oliet, Thomas Tourdias
Memory impairment is an early and disabling manifestation of multiple sclerosis whose anatomical and biological substrates are still poorly understood. We thus investigated whether memory impairment encountered at the early stage of the disease could be explained by a differential vulnerability of particular hippocampal subfields. By using experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, we identified that early memory impairment was associated with selective alteration of the dentate gyrus as pinpointed in vivo with diffusion-tensor-imaging (DTI)...
November 12, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27497819/minocycline-ameliorates-d-galactose-induced-memory-deficits-and-loss-of-arc-arg3-1-expression
#2
Xu Li, Fen Lu, Wei Li, Jun Xu, Xiao-Jing Sun, Ling-Zhi Qin, Qian-Lin Zhang, Yong Yao, Qing-Kai Yu, Xin-Liang Liang
Dysfunction of learning and memory is widely found in many neurological diseases. Understanding how to preserve the normal function of learning and memory will be extremely beneficial for the treatment of these diseases. However, the possible protective effect of minocycline in memory impairment is unknown. We used the well-established D-galactose rat amnesia model and two behavioral tasks, the Morris water maze and the step-down task, for memory evaluation. Western blot and PCR were used to examine the protein and mRNA levels of Arc/Arg3...
October 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/27436232/signs-of-enhanced-sleep-and-sleep-associated-memory-processing-following-the-anti-inflammatory-antibiotic-minocycline-in-men
#3
Luciana Besedovsky, Eva-Maria Schmidt, Barbara Linz, Susanne Diekelmann, Tanja Lange, Jan Born
Pro-inflammatory cytokines can promote sleep and neuronal processes underlying memory formation. However, this has mainly been revealed in animal studies. In this double-blind, placebo-controlled within-subject designed study, we examined how changes in the balance between pro- and anti-inflammatory signalling affect sleep and sleep-associated memory consolidation in humans. After learning declarative memory tasks (word pairs, texts) and a procedural memory task (finger tapping) in the evening, 21 healthy young men orally received either 200 mg of the anti-inflammatory antibiotic minocycline or placebo shortly before nocturnal sleep...
July 19, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27357391/minocycline-attenuates-interferon-%C3%AE-induced-impairments-in-rat-fear-extinction
#4
Qiang Bi, Lijuan Shi, Pingting Yang, Jianing Wang, Ling Qin
BACKGROUND: Extinction of conditioned fear is an important brain function for animals to adapt to a new environment. Accumulating evidence suggests that innate immune cytokines are involved in the pathology of psychotic disorders. However, the involvement of cytokines in fear dysregulation remains less investigated. In the present study, we investigated how interferon (IFN)-α disrupts the extinction of conditioned fear and propose an approach to rescue IFN-α-induced neurologic impairment...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27291517/chronic-minocycline-treatment-improves-social-recognition-memory-in-adult-male-fmr1-knockout-mice
#5
Suk Yu Yau, Christine Chiu, Mariana Vetrici, Brian R Christie
Fragile X syndrome (FXS) is caused by a mutation in the Fmr1 gene that leads to silencing of the gene and a loss of its gene product, Fragile X mental retardation protein (FMRP). Some of the key behavioral phenotypes for FXS include abnormal social anxiety and sociability. Here we show that Fmr1 knock-out (KO) mice exhibit impaired social recognition when presented with a novel mouse, and they display normal social interactions in other sociability tests. Administering minocycline to Fmr1 KO mice throughout critical stages of neural development improved social recognition memory in the novel mouse recognition task...
October 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27130658/neuroinflammation-regulates-cognitive-impairment-in-socially-defeated-mice
#6
Madeline L Pfau, Scott J Russo
Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.
June 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27108901/-reduction-in-hypoxia-derived-neuroinflammation-and-dysfunctional-glutamate-transporters-by-minocycline-may-restore-hypoxia-injured-cognition-of-neonatal-rat
#7
Hong-Chun Li, Jie Xiao, Yi-Long Huang, Long-Jun Li, Hong Jiang, Li-Xuan Huang, Ting Yang, Ling Yang, Fan Li
The aim of the present study was to investigate the effects of minocycline on cognitive functions in neonatal rat after hypoxia exposure and the underlying mechanism. A model of hypoxic brain damage (HBD) was developed by exposing postnatal 1 day (P1) rats to systemic hypoxia. The rats were intraperitoneally injected with normal saline (Hy group) or minocycline (Hy + M group) 2 h after hypoxia exposure. Some other P1 rats that were not subjected to systemic hypoxia were used as normal control (NG group). The Y-maze test was used to evaluate learning and memory ability on postnatal day 30...
April 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27061744/minocycline-attenuates-post-operative-cognitive-impairment-in-aged-mice-by-inhibiting-microglia-activation
#8
Hui-Lin Wang, Hua Liu, Zhang-Gang Xue, Qing-Wu Liao, Hao Fang
Although it is known that isoflurane exposure or surgery leads to post-operative cognitive dysfunction in aged rodents, there are few clinical interventions and treatments available to prevent this disorder. Minocycline (MINO) produces neuroprotection from several neurodegenerative diseases and various experimental animal models. Therefore, we set out to investigate the effects of MINO pre-treatment on isoflurane or surgery induced cognitive impairment in aged mice by assessing the hippocampal-dependent spatial memory performance using the Morris water maze task...
September 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/26937001/neuroinflammatory-dynamics-underlie-memory-impairments-after-repeated-social-defeat
#9
Daniel B McKim, Anzela Niraula, Andrew J Tarr, Eric S Wohleb, John F Sheridan, Jonathan P Godbout
UNLABELLED: Repeated social defeat (RSD) is a murine stressor that recapitulates key physiological, immunological, and behavioral alterations observed in humans exposed to chronic psychosocial stress. Psychosocial stress promotes prolonged behavioral adaptations that are associated with neuroinflammatory signaling and impaired neuroplasticity. Here, we show that RSD promoted hippocampal neuroinflammatory activation that was characterized by proinflammatory gene expression and by microglia activation and monocyte trafficking that was particularly pronounced within the caudal extent of the hippocampus...
March 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26845126/pharmacotherpy-and-alzheimer-s-disease-the-m-drugs-melatonin-minocycline-modafinil-and-memantine-approach
#10
Mak Adam Daulatzai
Despite advances in understanding the pathophysiology of Alzheimer's disease (AD), its therapy remains largely symptomatic and supportive. Acetylcholinesterase inhibitors - the first-line drugs used today do not prevent and treat AD. So far, over 90 Phase 3 trials of AD have been unsuccessful with 99.0% failure rate. There is, therefore, an urgent need to find effective new therapies for AD. Owing to the multifactorial nature of AD pathogenesis, polypharmacy with drugs that target heterogeneous pathophysiological pathways, needs to be considered...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26801406/cognitive-remission-a-novel-objective-for-the-treatment-of-major-depression
#11
REVIEW
Beatrice Bortolato, Kamilla W Miskowiak, Cristiano A Köhler, Michael Maes, Brisa S Fernandes, Michael Berk, André F Carvalho
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD...
January 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/26385416/oligodendrogenesis-in-the-fornix-of-adult-mouse-brain-the-effect-of-lps-induced-inflammatory-stimulation
#12
Shohei Fukushima, Kazunori Nishikawa, Eriko Furube, Shiori Muneoka, Katsuhiko Ono, Hirohide Takebayashi, Seiji Miyata
Evidence have been accumulated that continuous oligodendrogenesis occurs in the adult mammalian brain. The fornix, projection and commissure pathway of hippocampal neurons, carries signals from the hippocampus to other parts of the brain and has critical role in memory and learning. However, basic characterization of adult oligodendrogenesis in this brain region is not well understood. In the present study, therefore, we aimed to examine the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) and the effect of acute inflammatory stimulation on oligodendrogenesis in the fornix of adult mouse...
November 19, 2015: Brain Research
https://www.readbyqxmd.com/read/26082974/adjunctive-minocycline-in-clozapine-treated-schizophrenia-patients-with-persistent-symptoms
#13
RANDOMIZED CONTROLLED TRIAL
Deanna L Kelly, Kelli M Sullivan, Joseph P McEvoy, Robert P McMahon, Heidi J Wehring, James M Gold, Fang Liu, Dale Warfel, Gopal Vyas, Charles M Richardson, Bernard A Fischer, William R Keller, Maju Mathew Koola, Stephanie M Feldman, Jessica C Russ, Richard S E Keefe, Jennifer Osing, Leeka Hubzin, Sharon August, Trina M Walker, Robert W Buchanan
OBJECTIVE: Clozapine is the most effective antipsychotic for treatment refractory people with schizophrenia, yet many patients only partially respond. Accumulating preclinical and clinical data suggest benefits with minocycline. We tested adjunct minocycline to clozapine in a 10-week, double-blind, placebo-controlled trial. Primary outcomes tested were positive, and cognitive symptoms, while avolition, anxiety/depression, and negative symptoms were secondary outcomes. METHODS: Schizophrenia and schizoaffective participants (n = 52) with persistent positive symptoms were randomized to receive adjunct minocycline (100 mg oral capsule twice daily; n = 29) or placebo (n = 23)...
August 2015: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26016627/inhibition-of-microglial-activation-contributes-to-propofol-induced-protection-against-post-cardiac-arrest-brain-injury-in-rats
#14
Wei Wang, Rui Lu, Da-Yun Feng, Li-Rong Liang, Bing Liu, Hui Zhang
It has been suggested that propofol can modulate microglial activity and hence may have potential roles against neuroinflammation following brain ischemic insult. However, whether and how propofol can inhibit post-cardiac arrest brain injury via inhibition of microglia activation remains unclear. A rat model of asphyxia cardiac arrest (CA) was created followed by cardiopulmonary resuscitation. CA induced marked microglial activation in the hippocampal CA1 region, revealed by increased OX42 and P2 class of purinoceptor 7 (P2X7R) expression, as well as p38 MAPK phosphorylation...
September 2015: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26001832/heat-stress-induced-memory-impairment-is-associated-with-neuroinflammation-in-mice
#15
Wonil Lee, Minho Moon, Hyo Geun Kim, Tae Hee Lee, Myung Sook Oh
BACKGROUND: Heat stress induces many pathophysiological responses and has a profound impact on brain structure. It has been demonstrated that exposure to high temperature induces cognitive impairment in experimental animals and humans. Although the effects of heat stress have long been studied, the mechanisms by which heat stress affects brain structure and cognition not well understood. METHODS: In our longitudinal study of mice exposed to heat over 7, 14, or 42 days, we found that heat stress time dependently impaired cognitive function as determined by Y-maze, passive avoidance, and novel object recognition tests...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25860202/transfusion-of-old-rbcs-induces-neuroinflammation-and-cognitive-impairment
#16
Hongying Tan, Jiangjiang Bi, Yunzhen Wang, Junfeng Zhang, Zhiyi Zuo
OBJECTIVES: Transfusing RBCs stored for longer than 14 days (old RBC) in humans is common. This transfusion can injure organs, such as lungs and kidneys. We determined whether transfusion with old RBC injured brain. DESIGN: Prospective, controlled animal study. SETTING: University research laboratory. SUBJECTS: Adult male Sprague-Dawley rats. INTERVENTIONS: Six-month-old Sprague-Dawley rats lost 20% total blood volume and then received RBC prepared from equal volume of the lost blood...
August 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/25838119/minocycline-enhances-hippocampal-memory-neuroplasticity-and-synapse-associated-proteins-in-aged-c57-bl-6-mice
#17
Ying Jiang, Yingying Liu, Cansheng Zhu, Xiaomeng Ma, Lili Ma, Linli Zhou, Qiling Huang, Lei Cen, Rongbiao Pi, Xiaohong Chen
Previous studies have suggested that minocycline can attenuate cognitive deficits in animal models of conditions such as Alzheimer's disease and cerebral ischemia through inhibiting microglia associated anti-inflammatory actions. However the pathway that minocycline targets to enhance cognitive performance is not fully defined. Here we examined the effects of minocycline on learning and memory in aged (22-month-old) C57 BL/6 mice. We treated one group of mice with minocycline (30 mg/kg/day), and another group of mice with donepezil (2 mg/kg/day) as a positive control...
May 2015: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/25830666/phenotypic-dysregulation-of-microglial-activation-in-young-offspring-rats-with-maternal-sleep-deprivation-induced-cognitive-impairment
#18
Qiuying Zhao, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Wei Jiang, Xiaohui Wu, Shuo Yan, Yubo Chen, Cheng Peng, Zili You
Despite the potential adverse effects of maternal sleep deprivation (MSD) on physiological and behavioral aspects of offspring, the mechanisms remain poorly understood. The present study was intended to investigate the roles of microglia on neurodevelopment and cognition in young offspring rats with prenatal sleep deprivation. Pregnant Wistar rats received 72 h sleep deprivation in the last trimester of gestation, and their prepuberty male offspring were given the intraperitoneal injection with or without minocycline...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25750531/minocycline-upregulates-cyclic-amp-response-element-binding-protein-and-brain-derived-neurotrophic-factor-in-the-hippocampus-of-cerebral-ischemia-rats-and-improves-behavioral-deficits
#19
Yu Zhao, Ming Xiao, Wenbo He, Zhiyou Cai
BACKGROUND AND PURPOSE: The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also pivotal in the switch from short-term to long-term memory. Brain-derived neurotrophic factor (BDNF) seems a promising avenue in the treatment of cerebral ischemia injury since this neurotrophin could stimulate structural plasticity and repair cognitive impairment. Several findings have displayed that the dysregulation of the CREB-BDNF cascade has been involved in cognitive impairment...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25585814/minocycline-alleviates-sevoflurane-induced-cognitive-impairment-in-aged-rats
#20
Yue Tian, Shanbin Guo, Xiuying Wu, Ling Ma, Xiaochun Zhao
Minocycline has been implicated in the treatment for multiple diseases in the nervous system for its neuroprotective properties. However, the mechanism by which minocycline benefits postoperative anesthesia-induced cognitive dysfunction is still unclear. In this study, we introduced minocycline to a rat model of anesthetic-induced learning and memory impairment, to investigate the effects of minocycline on neuroinflammation, beta amyloid (Aβ) deposition, and activation of nuclear factor κB (NF-κB) signaling pathway in the hippocampus...
May 2015: Cellular and Molecular Neurobiology
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