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minocycline and memory consolidation

Luciana Besedovsky, Eva-Maria Schmidt, Barbara Linz, Susanne Diekelmann, Tanja Lange, Jan Born
Pro-inflammatory cytokines can promote sleep and neuronal processes underlying memory formation. However, this has mainly been revealed in animal studies. In this double-blind, placebo-controlled within-subject designed study, we examined how changes in the balance between pro- and anti-inflammatory signalling affect sleep and sleep-associated memory consolidation in humans. After learning declarative memory tasks (word pairs, texts) and a procedural memory task (finger tapping) in the evening, 21 healthy young men orally received either 200 mg of the anti-inflammatory antibiotic minocycline or placebo shortly before nocturnal sleep...
July 19, 2016: Journal of Psychopharmacology
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