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https://www.readbyqxmd.com/read/29433012/talking-about-male-body-based-contraceptives-the-counseling-visit-and-the-feminization-of-contraception
#1
Katrina Kimport
In developed countries, women bear the primary, and sometimes exclusive, responsibility for preventing pregnancy in heterosexual sexual relations. This unequal burden is not an intrinsic fact; it is the consequence of broad social narratives and interpersonal negotiations. The contraceptive counseling visit is increasingly recognized as a site of the discursive production of normative ideas about reproduction, suggesting that clinicians themselves may contribute to the assignment of responsibility for contraceptive labor to women (i...
February 2, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29422297/-development-of-the-facial-feminization-surgery-patient-s-satisfaction-questionnaire-qesff1-qualitative-phase
#2
C Verbruggen, R Weigert, P Corre, V Casoli, M Bondaz
OBJECTIVE: Facial feminization surgery is becoming a more frequently requested procedure in transsexual male to female patients transformation. A global way of reporting outcomes data and showing the beneficial impact of this specific procedure is necessary. The objective of this study is to develop a reliable and valid tool to report patients' outcomes after facial feminization surgery. METHODS: A systematic literature review, input from experts working with transsexual patients and patient interviews were used to develop the conceptual framework of the questionnaire...
February 5, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29403152/adrenocortical-carcinoma-characterized-by-gynecomastia-a-case-report
#3
Takako Takeuchi, Yuko Yoto, Akira Ishii, Takeshi Tsugawa, Masaki Yamamoto, Tsukasa Hori, Hotaka Kamasaki, Kazutaka Nogami, Takanori Oda, Akihiro Nui, Sachiko Kimura, Takuya Yamagishi, Keiko Homma, Tomonobu Hasegawa, Maki Fukami, Yoko Watanabe, Hidehiko Sasamoto, Hiroyuki Tsutsumi
We present a 4-yr-old boy with adrenocortical carcinoma (ACC), diagnosed due to the appearance of gynecomastia as the presenting symptom. Six months prior to admission, an acute growth spurt along with the development of bilateral breast swelling was observed. He did not present any features of virilization, including enlargement of the testes, increase in testis volume, and penis size. Laboratory investigations showed gonadotropin-independent hypergonadism, with low LH/ FSH levels and elevated estradiol/testosterone levels...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29398588/preliminary-report-surgical-outcomes-following-genitoplasty-in-children-with-moderate-to-severe-genital-atypia
#4
K J Bernabé, N J Nokoff, D Galan, D Felsen, C E Aston, P Austin, L Baskin, Y-M Chan, E Y Cheng, D A Diamond, R Ellens, A Fried, S Greenfield, T Kolon, B Kropp, Y Lakshmanan, S Meyer, T Meyer, A M Delozier, L L Mullins, B Palmer, A Paradis, P Reddy, K J Scott Reyes, M Schulte, J M Swartz, E Yerkes, C Wolfe-Christensen, A B Wisniewski, D P Poppas
INTRODUCTION: Prior studies of outcomes following genitoplasty have reported high rates of surgical complications among children with atypical genitalia. Few studies have prospectively assessed outcomes after contemporary surgical approaches. OBJECTIVE: The current study reported the occurrence of early postoperative complications and of cosmetic outcomes (as rated by surgeons and parents) at 12 months following contemporary genitoplasty procedures in children born with atypical genitalia...
February 1, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29389999/chinmo-prevents-transformer-alternative-splicing-to-maintain-male-sex-identity
#5
Lydia Grmai, Bruno Hudry, Irene Miguel-Aliaga, Erika A Bach
Reproduction in sexually dimorphic animals relies on successful gamete production, executed by the germline and aided by somatic support cells. Somatic sex identity in Drosophila is instructed by sex-specific isoforms of the DMRT1 ortholog Doublesex (Dsx). Female-specific expression of Sex-lethal (Sxl) causes alternative splicing of transformer (tra) to the female isoform traF. In turn, TraF alternatively splices dsx to the female isoform dsxF. Loss of the transcriptional repressor Chinmo in male somatic stem cells (CySCs) of the testis causes them to "feminize", resembling female somatic stem cells in the ovary...
February 1, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29380654/how-is-internal-migration-reshaping-metropolitan-populations-in-latin-america-a-new-method-and-new-evidence
#6
Jorge Rodríguez-Vignoli, Francisco Rowe
Internal migration is a key driver of patterns of human settlement and socio-economic development, but little is known about its compositional impacts. Exploiting the wide availability of census data, we propose a method to quantify the internal migration impacts on local population structures, and estimate these impacts for eight large Latin American cities. We show that internal migration generally had small feminizing, downgrading educational, and demographic window effects: reducing the local sex ratio, lowering the average years of schooling, and raising the share of working-age population due to an increased young adult population...
January 30, 2018: Population Studies
https://www.readbyqxmd.com/read/29372185/case-report-induced-lactation-in-a-transgender-woman
#7
Tamar Reisman, Zil Goldstein
Objective: Our report describes a case of nonpuerperal induced lactation in a transgender woman. Methods: We present the relevant clinical and laboratory findings, along with a review of the relevant literature. Results: A 30-year-old transgender woman who had been receiving feminizing hormone therapy for the past 6 years presented to our clinic with the goal of being able to breastfeed her adopted infant. After implementing a regimen of domperidone, estradiol, progesterone, and breast pumping, she was able to achieve sufficient breast milk volume to be the sole source of nourishment for her child for 6 weeks...
2018: Transgender Health
https://www.readbyqxmd.com/read/29344575/mammary-myofibroblastoma-in-a-transgender-patient-on-feminizing-hormones-literature-review-and-case-report
#8
Jane O'Bryan, Carolyn Wolf-Gould, Yoshiro Matsuo
Purpose: Defining the risk of neoplasia associated with gender-affirming hormone therapy (GAHT) is a priority for transgender medical research. The purposes of this article are to present a unique case of breast neoplasia in a transgender individual and to review the existing evidence base on GAHT as a potential risk for breast pathology. Methods: We present the case of a 76-year-old transgender patient who developed an estrogen receptor-positive mammary myofibroblastoma (MFB) after 13 months of treatment on feminizing hormones...
2018: Transgender Health
https://www.readbyqxmd.com/read/29316410/environmental-warming-and-feminization-of-one-of-the-largest-sea-turtle-populations-in-the-world
#9
Michael P Jensen, Camryn D Allen, Tomoharu Eguchi, Ian P Bell, Erin L LaCasella, William A Hilton, Christine A M Hof, Peter H Dutton
Climate change affects species and ecosystems around the globe [1]. The impacts of rising temperature are particularly pertinent in species with temperature-dependent sex determination (TSD), where the sex of an individual is determined by incubation temperature during embryonic development [2]. In sea turtles, the proportion of female hatchlings increases with the incubation temperature. With average global temperature predicted to increase 2.6°C by 2100 [3], many sea turtle populations are in danger of high egg mortality and female-only offspring production...
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29314190/comparing-the-effects-of-atrazine-and-an-environmentally-relevant-mixture-on-estrogen-responsive-gene-expression-in-the-northern-leopard-frog-and-the-fathead-minnow
#10
Jonathan M Ali, Lindsey A Knight, Del L D'Souza, Alan S Kolok
In Nebraska, fish are exposed to herbicides in agricultural runoff. Study objectives were to determine 1) if fathead minnows and northern leopard frogs exposed to atrazine experience alterations in gene expression, and 2) whether these changes are elicited by a simulated herbicide mixture. Following a 7-day exposure to atrazine female minnows were defeminized, while male frogs were feminized. The mixture did not elicit statistically significant effects in either species. This article is protected by copyright...
January 4, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29284187/sex-antagonistic-genes-xy-recombination-and-feminized-y-chromosomes
#11
Elisa Cavoto, Samuel Neuenschwander, Jérôme Goudet, Nicolas Perrin
The canonical model of sex-chromosome evolution predicts that sex-antagonistic (SA) genes play an instrumental role in the arrest of XY recombination and ensuing Y-chromosome degeneration. Although this model might account for the highly differentiated sex chromosomes of birds and mammals, it does not fit the situation of many lineages of fish, amphibians or non-avian reptiles, where sex chromosomes are maintained homomorphic through occasional XY recombination and/or high turnover rates. Such situations call for alternative explanatory frameworks...
December 28, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29226967/gender-specific-expression-of-gibberellic-acid-insensitive-is-critical-for-unisexual-organ-initiation-in-dioecious-spinacia-oleracea
#12
Nicholas W West, Edward M Golenberg
While unisexual flowers have evolved repeatedly throughout angiosperm families, the actual identification of sex-determining genes has been elusive, and their regulation within populations remains largely undefined. Here, we tested the mechanism of the feminization pathway in cultivated spinach (Spinacia oleracea), and investigated how this pathway may regulate alternative sexual development. We tested the effect of gibberellic acid (GA) on sex determination through exogenous applications of GA and inhibitors of GA synthesis and proteasome activity...
December 11, 2017: New Phytologist
https://www.readbyqxmd.com/read/29216900/treatment-with-a-dna-methyltransferase-inhibitor-feminizes-zebrafish-and-induces-long-term-expression-changes-in-the-gonads
#13
Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués, Francesc Piferrer
BACKGROUND: The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methyltransferase (dnmt) inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), which is approved for the treatment of acute myeloid leukaemia and is under active investigation for the treatment of solid tumours. Several dose-response experiments were carried out during two periods, including not only the very first days of development (0-6 days post-fertilization, dpf), as done in previous studies, but also, and as a novelty, the period of gonadal development (10-30 dpf)...
December 8, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29211317/neurobiology-of-gender-identity-and-sexual-orientation
#14
REVIEW
Charles E Roselli
Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, but not always. This review discusses the relationship of sexual identity and sexual orientation to prenatal factors that act to shape the development of the brain and the expression of sexual behaviors in animals and humans. One major influence discussed relates to organizational effects that the early hormone environment exerts on both gender identity and sexual orientation...
December 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29208362/feminizing-effects-of-exposure-to-corexit-enhanced-water-accommodated-fraction-of-crude-oil-in-vitro-on-sex-determination-in-alligator-mississippiensis
#15
Cameron E Williams, Nicole A McNabb, Arnold Brunell, Russell H Lowers, Yoshinao Katsu, Demetri D Spyropoulos, Satomi Kohno
Deepwater Horizon spilled over 200 million gallons of oil into the waters of the Gulf of Mexico in 2010. In an effort to contain the spill, chemical dispersants were applied to minimize the amount of oil reaching coastal shorelines. However, the biological impacts of chemically-dispersed oil are not well characterized, and there is a particular lack of knowledge concerning sublethal long-term effects of exposure. This study examined potential estrogenic effects of CWAF, Corexit 9500-enhanced water-accommodated fraction of oil, by examining its effect on estrogen receptors and sex determination in the American alligator, Alligator mississippiensis...
December 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29203388/the-occurrence-of-intersex-fishes-in-boulder-creek-colorado-is-a-recent-phenomenon
#16
David O Norris, Ashley L Bolden, Alan M Vajda
Gonads were examined visually and histologically from white sucker (Catostomus commersoni) and fathead minnows (Pimephales promelas) isolated from museum specimens collected from Boulder Creek, Colorado. These fishes were collected between 42 and 102 years ago before addition of large quantities of estrogenic chemicals via wastewater effluent was reported to disrupt reproductive structures and functions in white suckers living in Boulder Creek downstream of the wastewater treatment facility (WWTF) and in test exposures of fathead minnows to wastewater effluent at the WWTF...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29185871/psychometric-and-faciometric-support-for-observable-facial-feminization-in-gay-men
#17
Julia M Robertson, Barbara E Kingsley, Gina C Ford
Though male homosexuality appears to be evolutionarily paradoxical, phenotypic feminization has been offered as a route for three current models positing a genetic basis for male homosexuality. We tested whether facial feminization is observable in gay men in two studies. In Study 1, using two composite images of gay and of heterosexual men, naive participants (N = 308) rated the 'gay' face more highly on stereotypically feminine traits and actual femininity and the 'heterosexual' face more highly on stereotypically masculine traits and actual masculinity...
November 29, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29178636/a-novel-splice-site-variant-in-cyp11a1-in-trans-with-the-p-e314k-variant-in-a-male-patient-with-congenital-adrenal-insufficiency
#18
Montserrat Lara-Velazquez, Alexander Perdomo-Pantoja, Patrick R Blackburn, Jennifer M Gass, Thomas R Caulfield, Paldeep S Atwal
BACKGROUND: The CYP11A1 gene encodes the cytochrome P450 side-chain cleavage enzyme, which is essential for steroid formation. Recessive variants in this gene can lead to impairment of sexual differentiation caused by a complete or partial loss of steroid hormone production. The phenotypic spectrum in affected 46XY males may vary from surgically repairable defects including cryptorchidism and hypospadias to complete feminization of external gonads, accompanied by symptoms of adrenal dysfunction...
November 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29165635/breast-development-in-transwomen-after-one-year-of-cross-sex-hormone-therapy-results-of-a-prospective-multicenter-study
#19
Christel Josefa Maria de Blok, Maartje Klaver, Chantal Maria Wiepjes, Nienke Marije Nota, Annemieke Corine Heijboer, Alessandra Daphne Fisher, Thomas Schreiner, Guy T'Sjoen, Martin den Heijer
Context: Breast development is a key feature of feminization and therefore important to transwomen (male-to-female transgender persons). However, it is not exactly known when breast development starts after initiating cross-sex hormone therapy (CHT) and how much growth may be expected of CHT alone. Objective: To investigate breast development in centimeters and bra cup-sizes in transwomen during their first year of CHT, and whether clinical or laboratory parameters predict the breast development...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161221/from-freud-to-feminism-gendered-constructions-of-blame-across-theories-of-child-sexual-abuse
#20
Corry Azzopardi, Ramona Alaggia, Barbara Fallon
Most theories of child sexual abuse are, to some degree, gendered, with nonoffending mothers bearing the burden of blame, ideologically and legally, for the transgressions of predominantly male offenders. This article explores the social construction of blame for child sexual abuse via critical analyses of evolving theoretical perspectives on maternal culpability for the inception and maintenance of abuse dynamics. Drawing on selected conceptual and research knowledge that supports and refutes anecdotal claims, this synthesis of the literature culminates in the proposal of an evidence-informed, feminist-grounded, multitheoretical child sexual abuse framework that disrupts dominant mother-blaming discourse and guides socially just and ethically responsive policy, practice, and research...
November 21, 2017: Journal of Child Sexual Abuse
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