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https://www.readbyqxmd.com/read/28638119/neuroimmunology-and-neuroepigenetics-in-the-establishment-of-sex-differences-in-the-brain
#1
REVIEW
Margaret M McCarthy, Bridget M Nugent, Kathryn M Lenz
The study of sex differences in the brain is a topic of neuroscientific study that has broad reaching implications for culture, society and biomedical science. Recent research in rodent models has led to dramatic shifts in our views of the mechanisms underlying the sexual differentiation of the brain. These include the surprising discoveries of a role for immune cells and inflammatory mediators in brain masculinization and a role for epigenetic suppression in brain feminization. How and to what degree these findings will translate to human brain development will be questions of central importance in future research in this field...
June 22, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28632080/lesbian-disclosure-and-health-care-seeking-in-the-united-states-a-replication-study
#2
Melissa St Pierre
The current study explored factors associated with lesbian disclosure to health care providers (HCPs) and engagement in preventative health behaviors by replicating and extending a Canadian path analysis study with a sample of U.S. lesbians. Both patient (education, feminism, global outness, and internalized homophobia) and HCP-related (lesbian-friendly HCPs and patient comfort) factors were either directly or indirectly associated with disclosure and engagement in preventative health behaviors, including avoidance of health-compromising behaviors (e...
February 17, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28626437/counter-stereotypes-and-feminism-promote-leadership-aspirations-in-highly-identified-women
#3
Carola Leicht, Małgorzata A Gocłowska, Jolien A Van Breen, Soledad de Lemus, Georgina Randsley de Moura
Although women who highly identify with other women are more susceptible to stereotype threat effects, women's identification might associate with greater leadership aspirations contingent on (1) counter-stereotype salience and (2) feminist identification. When gender counter-stereotypes are salient, women's identification should associate with greater leadership aspiration regardless of feminism, while when gender stereotypes are salient, women's identification would predict greater leadership aspirations contingent on a high level of feminist identification...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28623855/authentic-feminist-authenticity-and-feminist-identity-in-teenage-feminists-talk
#4
Octavia Calder-Dawe, Nicola Gavey
This article explores how young people's feminist identities take shape in conjunction with a contemporary ideal of personal authenticity: to know and to express the 'real me'. Drawing from interviews with 18 teenagers living in Auckland, New Zealand, we examine a novel convergence of authenticity and feminism in participants' identity talk. For social psychologists interested in identity and politics, this convergence is intriguing: individualizing values such as authenticity are generally associated with disengagement with structural critique and with a repudiation of politicized and activist identities...
June 17, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28618705/re-should-we-question-early-feminizing-genitoplasty-for-patients-with-congenital-adrenal-hyperplasia-and-xx-karyotype
#5
Douglas A Canning
No abstract text is available yet for this article.
July 2017: Journal of Urology
https://www.readbyqxmd.com/read/28602421/endocrine-disruption-effects-in-male-and-intersex-roach-rutilus-rutilus-l-from-french-rivers-an-integrative-approach-based-on-subcellular-to-individual-responses
#6
Perrine Geraudie, Marie Gerbron, Christophe Minier
Among the chemicals found in the aquatic environment, some have been reported to interact with the endocrine system of organisms and have been identified as endocrine disrupting compounds. In this study, we have assessed the biological effects due to environmental estrogenic compounds in adult male roach (Rutilus rutilus). Wild fish were collected in the Seine river, and one of its affluent, the Epte river in Normandy, France and impacts on endocrine and reproductive functions have been assessed. This study provides innovative data on the intersex condition in wild fish that are crucial to understand estrogenic contamination impacts and maintenance of sustainable fish population...
June 5, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28599997/translation-cultural-adaptation-and-preliminary-evaluation-of-the-spanish-version-of-the-transgender-voice-questionnaire-for-male-to-female-transsexuals-tvq-mtf
#7
Elena Mora, Alvaro Carrillo, Ana Giribet, Antonio Becerra, Ma Jesús Lucio, Ignacio Cobeta
OBJECTIVE: This study aimed to perform translation, cross-cultural adaptation, and validation of the Spanish version of the Transsexual Voice Questionnaire for Male-to-Female Transsexuals (TVQ (MtF)). STUDY DESIGN: This is a prospective study. SETTING: The study was conducted by the Gender Identity Unit and the Voice Unit of a tertiary hospital referral center for surgical feminization of the voice. SUBJECTS AND METHODS: The study had two parts: translation and adaptation of the TVQ (MtF) with the following actions: translation (with authorization and consensus of the authors of the original questionnaire), back-translation, pretesting, and final version; and preliminary study of the psychometric properties (feasibility, internal consistency, test-retest reliability, construct validity, discriminant validity, and ceiling and floor effects)...
June 6, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28566542/wolbachia-induced-meiotic-drive-and-feminization-is-associated-with-an-independent-occurrence-of-selective-mitochondrial-sweep-in-a-butterfly
#8
Mai Miyata, Tatsuro Konagaya, Kenji Yukuhiro, Masashi Nomura, Daisuke Kageyama
Maternally inherited Wolbachia endosymbionts manipulate arthropod reproduction in various ways. In the butterfly Eurema mandarina, a cytoplasmic incompatibility-inducing Wolbachia strain wCI and the associated mtDNA haplotypes are known to originate from the sister species Eurema hecabe, which offered a good case study for microbe-mediated hybrid introgression. Besides wCI, some females with the Z0 karyotype harbour a distinct Wolbachia strain wFem, which causes all-female production by meiotic drive and feminization...
May 2017: Biology Letters
https://www.readbyqxmd.com/read/28566353/sex-reversal-induces-size-and-performance-differences-among-females-of-the-african-pygmy-mouse-mus-minutoides
#9
Samuel Ginot, Julien Claude, Julie Perez, Frederic Veyrunes
Differences in biological performance, at both intra- and inter-specific levels, have often been linked to morphology but seldom to behavioural or genotypic effects. We tested performance at the intraspecific level by measuring bite force in the African pygmy mouse, Mus minutoides. This species displays an unusual sex determination system, with sex-reversed, X*Y females carrying a feminizing X* chromosome. X*Y females cannot be differentiated from XX females based on external or gonadal morphology; however, they are known to be more aggressive...
June 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28558994/ppar%C3%AE-independent-transcriptional-targets-of-perfluoroalkyl-acids-revealed-by-transcript-profiling
#10
Mitchell B Rosen, Kaberi P Das, John Rooney, Barbara Abbott, Christopher Lau, J Christopher Corton
Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) are readily found in the tissues of humans and wildlife. While PFOA and PFOS have been the subject of numerous studies since they were first described over a decade ago, less is known about the biological activity of PFHxS and PFNA. Most PFAAs are activators of peroxisome proliferator-activated receptor α (PPARα), although the biological effects of these compounds are likely mediated by other factors in addition to PPARα...
May 27, 2017: Toxicology
https://www.readbyqxmd.com/read/28546067/are-there-consistent-behavioral-differences-between-sexes-and-male-color-morphs-in-pelvicachromis-pulcher
#11
Cheryl M Sedlak Seaver, Peter L Hurd
Adult sex ratios in the kribensis cichlid (Pelvicachromis pulcher) are influenced by environmental conditions during early development. These environmental sex-determining factors may also organize life-long variation in social behavior within each sex. If this is true, then individual differences in behavior may be, at least in part, expressions of the relative strength of sexual differentiation of that individual. As adults, kribensis males take on one of four alternative color morphs. Males of the yellow morph tend toward breeding monogamously and are produced at higher frequency under female-biasing environmental conditions, while males of the red morph tend more towards breeding polygynously and are produced more frequently by male-biasing early environments...
May 10, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28545157/the-aminoestrogen-prolame-increases-recognition-memory-and-hippocampal-neuronal-spine-density-in-aged-mice
#12
Alfonso Diaz, Samuel Treviño, Rubén Vázquez-Roque, Berenice Venegas, Blanca Espinosa, Gonzalo Flores, Juan Manuel Fernández-G, Luis F Montaño, Jorge Guevara
The aging brain shows biochemical and morphological changes in the dendrites of pyramidal neurons from the limbic system associated with memory loss. Prolame (N-(3-hydroxy-1,3,5 (10) -estratrien-17β-yl) -3-hydroxypropylamine) is a non-feminizing aminoestrogen with antithrombotic activity that prevents neuronal deterioration, oxidative stress and neuroinflammation. Our aim was to evaluate the effect of prolame on motor and cognitive processes, as well as its influence on the dendritic morphology of neurons at the CA1, CA3 and granule cells of the dentate gyrus (DG) regions of hippocampus (HP), and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice...
May 25, 2017: Synapse
https://www.readbyqxmd.com/read/28542152/corrigendum-brain-feminization-requires-active-repression-of-masculinization-via-dna-methylation
#13
Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine, Margaret M McCarthy
No abstract text is available yet for this article.
May 25, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28533648/increased-f-fdg-uptake-in-bilateral-gynecomastia-secondary-to-feminizing-adrenal-tumor-a-rare-case-report-and-review-of-literature
#14
Priyanka Verma, Gaurav Malhotra, Sneha Kothari, Rajlaxmi Jagtap, Ramesh V Asopa
A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. The patient underwent a right adrenalectomy with the histopathology report confirming adrenocortical carcinoma...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28511205/-stability-and-change-of-medical-specialty-of-residents-over-four-years-of-postgraduate-training-in-germany
#15
Hendrik van den Bussche, Stine Ziegler, Lea Krause-Solberg, Martin Scherer
Aim We analyzed medical residents' preferences in Germany with regard to the specialization fields after 4 years of postgraduate training and compared them to their preferences in the years before, e. g. at the end of undergraduate education in a gender comparative perspective, including the influence of parenthood. Methods The study is based on annual postal surveys of students of 7 medical faculties in Germany from their last year of medical school ("Practical Year") until after 4 years of postgraduate training...
May 16, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28499525/consecutive-cyproterone-acetate-and-estradiol-treatment-in-late-pubertal-transgender-female-adolescents
#16
Lloyd J W Tack, Robin Heyse, Margarita Craen, Karlien Dhondt, Heidi Vanden Bossche, Jolien Laridaen, Martine Cools
BACKGROUND: Cyproterone acetate (CA) is an antiandrogenic progestin commonly used in adult transwomen to suppress endogenous androgens, often in combination with estrogens to induce feminization. AIM: To assess the (side) effects and biochemical changes of CA alone and in combination with estrogens in adolescent trans-girls. METHODS: This study was a retrospective analysis of clinical and biochemical data from 27 trans-girls who presented at Tanner stage G4 and were treated with CA monotherapy for at least 6 months (mean = 12 months) and then in combination with incremental doses of estrogens (CA + E; mean = 16 months)...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28492057/dermatologic-care-of-the-transgender-patient
#17
EDITORIAL
B A Ginsberg
Given the complexities of the transitioning process, transgender individuals may face unique dermatologic needs in addition to routine care. Exogenous hormones affect hair and sebum production, gender-confirming surgeries often require dermatologic pre- and postoperative interventions, and postoperative anatomy may show unique presentations of routine skin conditions. Aesthetic techniques that are often used for rejuvenation may have a role in facial feminization and masculinization and unfortunately are too frequently performed by nonmedical personnel with negative consequences...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28488742/feminization-of-the-fat-distribution-pattern-of-children-and-adolescents-in-a-recent-german-population
#18
Christiane Scheffler, Melanie Dammhahn
OBJECTIVES: During the early 1990s, the economic and political situation in eastern Germany changed overnight. Here, we use the rare chance of an experiment-like setting in humans and aim to test whether the rapid change of environmental conditions in eastern Germany in the 1990s led to a change in the sex-specific fat distribution pattern, an endocrine-influenced phenotypic marker. METHODS: Based on a cross-sectional data set of 6- to 18-year-old girls and boys measured between 1982-1991 and 1997-2012, we calculated a skinfold ratio of triceps to subscapular and percentage of body fat...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28482773/gender-bias-in-hospital-leadership-a-qualitative-study-on-the-experiences-of-women-ceos
#19
Sophie Soklaridis, Ayelet Kuper, Cynthia R Whitehead, Genevieve Ferguson, Valerie H Taylor, Catherine Zahn
Purpose The purpose of this paper is to examine the experiences of gender bias among women hospital CEOs and explore to what these female leaders attribute their success within a male-dominated hospital executive leadership milieu. Design/methodology/approach This qualitative study involved 12 women hospital CEOs from across Ontario, Canada. Purposeful sampling techniques and in-depth qualitative interview methods were used to facilitate discussion around experiences of gender and leadership. Findings Responses fell into two groups: the first group represented the statement "Gender inequality is alive and well"...
April 10, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28468682/unto-the-third-generation-evidence-for-strong-familial-aggregation-of-physicians-psychologists-and-psychotherapists-among-first-year-medical-and-psychology-students-in-a-nationwide-austrian-cohort-census
#20
Ulrich S Tran, Nina Berger, Martin E Arendasy, Tobias Greitemeyer, Monika Himmelbauer, Florian Hutzler, Hans-Georg Kraft, Karl Oettl, Ilona Papousek, Oliver Vitouch, Martin Voracek
BACKGROUND: Medical students present higher numbers of physician relatives than expectable from the total population prevalence of physicians. Evidence for such a familial aggregation effect of physicians has emerged in investigations from the Anglo-American, Scandinavian, and German-speaking areas. In particular, past data from Austria suggest a familial aggregation of the medical, as well as of the psychological and psychotherapeutic, professions among medical and psychology undergraduates alike...
May 3, 2017: BMC Medical Education
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