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https://www.readbyqxmd.com/read/29216900/treatment-with-a-dna-methyltransferase-inhibitor-feminizes-zebrafish-and-induces-long-term-expression-changes-in-the-gonads
#1
Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués, Francesc Piferrer
BACKGROUND: The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methyltransferase (dnmt) inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), which is approved for the treatment of acute myeloid leukaemia and is under active investigation for the treatment of solid tumours. Several dose-response experiments were carried out during two periods, including not only the very first days of development (0-6 days post-fertilization, dpf), as done in previous studies, but also, and as a novelty, the period of gonadal development (10-30 dpf)...
December 8, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29211317/neurobiology-of-gender-identity-and-sexual-orientation
#2
REVIEW
Charles E Roselli
Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, but not always. This review discusses the relationship of sexual identity and sexual orientation to prenatal factors that act to shape the development of the brain and the expression of sexual behaviors in animals and humans. One major influence discussed relates to organizational effects that the early hormone environment exerts on both gender identity and sexual orientation...
December 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29208362/feminizing-effects-of-exposure-to-corexit-enhanced-water-accommodated-fraction-of-crude-oil-in-vitro-on-sex-determination-in-alligator-mississippiensis
#3
Cameron E Williams, Nicole A McNabb, Arnold Brunell, Russell H Lowers, Yoshinao Katsu, Demetri D Spyropoulos, Satomi Kohno
Deepwater Horizon spilled over 200 million gallons of oil into the waters of the Gulf of Mexico in 2010. In an effort to contain the spill, chemical dispersants were applied to minimize the amount of oil reaching coastal shorelines. However, the biological impacts of chemically-dispersed oil are not well characterized, and there is a particular lack of knowledge concerning sublethal long-term effects of exposure. This study examined potential estrogenic effects of CWAF, Corexit 9500-enhanced water-accommodated fraction of oil, by examining its effect on estrogen receptors and sex determination in the American alligator, Alligator mississippiensis...
December 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29203388/the-occurrence-of-intersex-fishes-in-boulder-creek-colorado-is-a-recent-phenomenon
#4
David O Norris, Ashley L Bolden, Alan M Vajda
Gonads were examined visually and histologically from white sucker (Catostomus commersoni) and fathead minnows (Pimephales promelas) isolated from museum specimens collected from Boulder Creek, Colorado. These fishes were collected between 42 and 102 years ago before addition of large quantities of estrogenic chemicals via wastewater effluent was reported to disrupt reproductive structures and functions in white suckers living in Boulder Creek downstream of the wastewater treatment facility (WWTF) and in test exposures of fathead minnows to wastewater effluent at the WWTF...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29185871/psychometric-and-faciometric-support-for-observable-facial-feminization-in-gay-men
#5
Julia M Robertson, Barbara E Kingsley, Gina C Ford
Though male homosexuality appears to be evolutionarily paradoxical, phenotypic feminization has been offered as a route for three current models positing a genetic basis for male homosexuality. We tested whether facial feminization is observable in gay men in two studies. In Study 1, using two composite images of gay and of heterosexual men, naive participants (N = 308) rated the 'gay' face more highly on stereotypically feminine traits and actual femininity and the 'heterosexual' face more highly on stereotypically masculine traits and actual masculinity...
November 29, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29178636/a-novel-splice-site-variant-in-cyp11a1-in-trans-with-the-p-e314k-variant-in-a-male-patient-with-congenital-adrenal-insufficiency
#6
Montserrat Lara-Velazquez, Alexander Perdomo-Pantoja, Patrick R Blackburn, Jennifer M Gass, Thomas R Caulfield, Paldeep S Atwal
BACKGROUND: The CYP11A1 gene encodes the cytochrome P450 side-chain cleavage enzyme, which is essential for steroid formation. Recessive variants in this gene can lead to impairment of sexual differentiation caused by a complete or partial loss of steroid hormone production. The phenotypic spectrum in affected 46XY males may vary from surgically repairable defects including cryptorchidism and hypospadias to complete feminization of external gonads, accompanied by symptoms of adrenal dysfunction...
November 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29165635/breast-development-in-transwomen-after-one-year-of-cross-sex-hormone-therapy-results-of-a-prospective-multicenter-study
#7
Christel Josefa Maria de Blok, Maartje Klaver, Chantal Maria Wiepjes, Nienke Marije Nota, Annemieke Corine Heijboer, Alessandra Daphne Fisher, Thomas Schreiner, Guy T'Sjoen, Martin den Heijer
Context: Breast development is a key feature of feminization and therefore important to transwomen (male-to-female transgender persons). However, it is not exactly known when breast development starts after initiating cross-sex hormone therapy (CHT) and how much growth may be expected of CHT alone. Objective: To investigate breast development in centimeters and bra cup-sizes in transwomen during their first year of CHT, and whether clinical or laboratory parameters predict the breast development...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161221/from-freud-to-feminism-gendered-constructions-of-blame-across-theories-of-child-sexual-abuse
#8
Corry Azzopardi, Ramona Alaggia, Barbara Fallon
Most theories of child sexual abuse are, to some degree, gendered, with nonoffending mothers bearing the burden of blame, ideologically and legally, for the transgressions of predominantly male offenders. This article explores the social construction of blame for child sexual abuse via critical analyses of evolving theoretical perspectives on maternal culpability for the inception and maintenance of abuse dynamics. Drawing on selected conceptual and research knowledge that supports and refutes anecdotal claims, this synthesis of the literature culminates in the proposal of an evidence-informed, feminist-grounded, multitheoretical child sexual abuse framework that disrupts dominant mother-blaming discourse and guides socially just and ethically responsive policy, practice, and research...
November 21, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29159310/factors-associated-with-gender-affirming-surgery-and-age-of-hormone-therapy-initiation-among-transgender-adults
#9
Noor Beckwith, Sari L Reisner, Shayne Zaslow, Kenneth H Mayer, Alex S Keuroghlian
Purpose: Gender-affirming surgeries and hormone therapy are medically necessary treatments to alleviate gender dysphoria; however, significant gaps exist in the research and clinical literature on surgery utilization and age of hormone therapy initiation among transgender adults. Methods: We conducted a retrospective review of electronic health record data from a random sample of 201 transgender patients of ages 18-64 years who presented for primary care between July 1, 2010 and June 30, 2015 (inclusive) at an urban community health center in Boston, MA...
2017: Transgender Health
https://www.readbyqxmd.com/read/29158897/feminist-approaches-to-anorexia-nervosa-a-qualitative-study-of-a-treatment-group
#10
Su Holmes, Sarah Drake, Kelsey Odgers, Jon Wilson
Background: Eating disorders (EDs) are now often approached as biopsychosocial problems. But it has been suggested by scholars interested in sociocultural factors that all is not equal within this biospsychosocial framework, with the 'social' aspects of the equation relegated to secondary factors within ED treatment contexts. Although sociocultural influences are well-established as risk factors for EDs, the exploration of whether or how such perspectives are useful in treatment has been little explored...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29153054/care-workers-in-argentina
#11
Valeria Esquivel, Francisca Pereyra
The working conditions, relative wages, and social standing of care occupations are the result of diverse causes that can worsen, improve, or neutralize the labor disadvantages usually found in care occupations. This article seeks to provide a perspective on the factors underlying care workers' working conditions in Argentina. It presents a comparative analysis of three highly feminized occupations-early education teachers, nurses, and domestic workers. After highlighting the different working conditions among these occupations, the paper focuses on the critically important role that unionization and state policies have played in defining each labor context in Argentina...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/29141766/molecular-detection-and-characterization-of-wolbachia-pipientis-from-culex-quinquefasciatus-collected-from-lahore-pakistan
#12
Muhammad Sajjad Sarwar, Nusrat Jahan, Fatima Shahbaz
The gram-negative, pleomorphic endosymbiont Wolbachia is known to infect a large number of insects and other arthropods naturally. This bacterium modifies the host biology, mainly causing reproductive alterations including feminization, death of male, parthenogenesis, and importantly cytoplasmic incompatibility. Wolbachia-induced cytoplasmic incompatibility results in nonviable offspring and vector population suppression. In addition, this bacterium rapidly spreads and propagates within the host population...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29137511/in-british-columbia-the-supply-of-primary-care-physicians-grew-but-their-rate-of-clinical-activity-declined
#13
Lindsay Hedden, Morris L Barer, Kimberlyn McGrail, Michael Law, Ivy L Bourgeault
Reports of a primary care shortage are ubiquitous in Canada and the United States. We used a population-based, retrospective cohort study to examine the extent to which the feminization and aging of the primary care physician workforce and secular trends may contribute to changes in the availability of primary care services. We used billing data for all primary care physicians in British Columbia for the period 2005-12. We used multivariate linear mixed-effects models to study physician remuneration and activity levels...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29128083/evolution-of-hepatocellular-carcinoma-epidemiology-in-c%C3%A3-te-d-ivoire
#14
REVIEW
Judith Didi-Kouko Coulibaly, Mireille Yeboua, Alphonsine Kouassi Mbengue, Emile Allah Kouadio, Henriette Anzouan-Kacou Kissi, Allah Yves-Omer Binan, Marie-Jeanne Lohoues Kouacou, Alain Attia, Dominique Yao N'Drin, Toussaint Toutou, Innocent Adoubi, Pascal Pineau
INTRODUCTION: Hepatocellular carcinoma is a major concern for Public health in West Africa. In Côte d'Ivoire, the bulk of our knowledge stems from studies conducted decades ago. Our aim was, thus, to assess whether the epidemiological features of this tumor changed recently. METHODS: Records from 863 patients diagnosed between 2007 and 2014 were analyzed. RESULTS: We observed major drifts concerning hepatocellular carcinoma with regards to the 1970-1980 period...
November 8, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29124738/transcripts-immunoprecipitated-with-sxl-protein-in-primordial-germ-cells-of-drosophila-embryos
#15
Ryoma Ota, Shumpei Morita, Masanao Sato, Shuji Shigenobu, Makoto Hayashi, Satoru Kobayashi
In Drosophila, Sex lethal (Sxl), an RNA binding protein, is required for induction of female sexual identity in both somatic and germline cells. Although the Sxl-dependent feminizing pathway in the soma was previously elucidated, the downstream targets for Sxl in the germline remained elusive. To identify these target genes, we selected transcripts associated with Sxl in primordial germ cells (PGCs) of embryos using RNA immunoprecipitation coupled to sequencing (RIP-seq) analysis. A total of 308 transcripts encoded by 282 genes were obtained...
November 10, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/29122702/estrogenic-effects-following-larval-exposure-to-the-putative-anti-estrogen-fulvestrant-in-the-fathead-minnow-pimephales-promelas
#16
Jonathan M Ali, Michael T Palandri, Alex T Kallenbach, Edwin Chavez, Jonathan Ramirez, Sathaporn Onanong, Daniel D Snow, Alan S Kolok
The objective of the present study was to investigate the consequences of early-life exposure to fulvestrant on estrogenic gene expression in fathead minnow larvae. To address this objective, fathead minnow larvae were exposed to fulvestrant (ICI 182,780) during the window of sexual differentiation between 0 to 30 days post-hatch (dph). The four treatment groups in this study included: filtered water controls (never exposed), solvent controls (ethanol 0.01%), and nominally low (0.10μg/L) and high (10.0μg/L) doses of fulvestrant...
November 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29110358/temporal-variation-in-brain-transcriptome-is-associated-with-the-expression-of-female-mimicry-as-a-sequential-male-alternative-reproductive-tactic-in-fish
#17
Sara D Cardoso, David Gonçalves, Alexander Goesmann, Adelino V M Canário, Rui F Oliveira
Distinct patterns of gene expression often underlie intra- and inter-sexual differences, and the study of this set of co-regulated genes is essential to understand the emergence of complex behavioural phenotypes. Here, we describe the development of a de novo transcriptome and brain gene expression profiles of wild-caught peacock blenny, Salaria pavo, an intertidal fish with sex-role reversal in courtship behaviour (i.e. females are the courting sex) and sequential alternative reproductive tactics in males (i...
November 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29108596/the-relationship-between-societal-change-and-rising-support-for-gender-egalitarianism-among-men-and-women-results-from-counterfactual-analyses-in-the-netherlands-1979-2012
#18
Paula Thijs, Manfred Te Grotenhuis, Peer Scheepers
This study examines the relationship between important social, cultural, economic, and demographic changes and the rise of support for gender egalitarianism within the Dutch population between 1979 and 2012. Cohort replacement, educational expansion, secularization, and the feminization of the labor force are important processes that have taken place in western societies in ways that may have fostered support for gender egalitarianism. Using unique data from 16 repeated cross-sectional surveys in the Netherlands, we estimate age-period-cohort regression models, and the outcomes are subsequently applied in counterfactual simulation designs...
November 2017: Social Science Research
https://www.readbyqxmd.com/read/29108546/cosmetic-concerns-among-men
#19
REVIEW
Marc Zachary Handler, David J Goldberg
Men are interested in reducing signs of aging, while maintaining a masculine appearance. A chief concern among men is maintenance of scalp hair. Men are also concerned with reducing under eye bags and dark circles. The concern of feminization is of significant importance. Neuromodulators remain the most common cosmetic procedure performed in men. Men often prefer a reduction in facial rhytids, as opposed to elimination of the lines. Softening facial lines in men is meant to maintain an appearance of wisdom, without appearing fragile...
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29108544/volumetric-structural-rejuvenation-for-the-male-face
#20
REVIEW
Neil S Sadick
Fillers and toxins are safe, quick, and require no downtime; the immediately visible results can boost a man's self-esteem, confidence, youthfulness, and sense of competitiveness in the personal and professional realms of the world. The approach to using these agents has changed from ironing out the skin to remove wrinkles and lines to a restructuring of the 3-dimensional face. This new strategy, volumetric structural rejuvenation (VSR), relies on intimate knowledge of facial anatomy and the pathophysiology of aging...
January 2018: Dermatologic Clinics
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