keyword
MENU ▼
Read by QxMD icon Read
search

contextual memory

keyword
https://www.readbyqxmd.com/read/28088683/effects-of-protease-activated-receptor-1-inhibition-on-anxiety-and-fear-following-status-epilepticus
#1
Mihail Fedoriuk, Dmytro Isaev, Oleg Krishtal, Gregory L Holmes, Elena Isaeva
Protease-activated receptor 1 (PAR1) is an important contributor to the pathogenesis of a variety of brain disorders associated with a risk of epilepsy development. Using the lithium-pilocarpine model of temporal lobe epilepsy (TLE), we recently showed that inhibition of this receptor during the first ten days after pilocarpine-induced status epilepticus (SE) results in substantial anti-epileptogenic and neuroprotective effects. As PAR1 is expressed in the central nervous system regions of importance for processing emotional reactions, including amygdala and hippocampus, and TLE is frequently associated with a chronic alteration of the functions of these regions, we tested the hypothesis that PAR1 inhibition could modulate emotionally driven behavioral responses of rats experiencing SE...
January 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28088551/individual-and-sex-differences-in-high-and-low-responder-phenotypes
#2
María B Carreira, Ricardo Cossio, Gabrielle B Britton
Individual differences in responses to a novel environment are an important tool to predict predisposition to neuropsychiatric disorders. One way to examine individual differences involves classifying animals based on locomotion in a novel context. In this study we focused on individual and sex differences by categorizing female and male mice as high (HR) or low responders (LR) on the basis of open field locomotion. We then assessed whether groups differed on behavioral measures of spontaneous alternations, anxiety, depression and contextual fear conditioning...
January 11, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28077709/semantic-congruence-accelerates-the-onset-of-the-neural-signals-of-successful-memory-encoding
#3
Pau A Packard, Antoni Rodríguez-Fornells, Nico Bunzeck, Berta Nicolás, Ruth de Diego-Balaguer, Lluís Fuentemilla
: As the stream of experience unfolds, our memory system rapidly transforms current inputs into long-lasting meaningful memories. A putative neural mechanism that strongly influences how input elements are transformed into meaningful memory codes relies on the ability to integrate them with existing structures of knowledge or schemas. However, it is not yet clear whether schema-related integration neural mechanisms occur during online encoding. In the current investigation, we examined the encoding-dependent nature of this phenomenon in humans...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28077707/organization-of-the-claustrum-to-entorhinal-cortical-connection-in-mice
#4
Takuma Kitanishi, Naoki Matsuo
: The claustrum, a subcortical structure situated between the insular cortex and striatum, is reciprocally connected with almost all neocortical regions. Based on this connectivity, the claustrum has been postulated to integrate multisensory information and, in turn, coordinate widespread cortical activity. Although studies have identified how sensory information is mapped onto the claustrum, the function of individual topographically arranged claustro-cortical pathways has been little explored...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28077002/pupil-size-behavior-during-on-line-processing-of-sentences
#5
G Fernández, J Biondi, S Castro, O Agamenonni
In the present work we analyzed the pupil size behavior of 40 subjects while they read well-defined sentences with different contextual predictability (i.e., regular sentences and proverbs). In general, pupil size increased when reading regular sentences, but when readers realized that they were reading proverbs their pupils strongly increase until finishing proverbs' reading. Our results suggest that an increased pupil size is not limited to cognitive load (i.e., relative difficulty in processing) because when participants accurately recognized words during reading proverbs, theirs pupil size increased too...
January 11, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28067903/modulation-of-excitation-on-parvalbumin-interneurons-by-neuroligin-3-regulates-the-hippocampal-network
#6
Jai S Polepalli, Hemmings Wu, Debanjan Goswami, Casey H Halpern, Thomas C Südhof, Robert C Malenka
Hippocampal network activity is generated by a complex interplay between excitatory pyramidal cells and inhibitory interneurons. Although much is known about the molecular properties of excitatory synapses on pyramidal cells, comparatively little is known about excitatory synapses on interneurons. Here we show that conditional deletion of the postsynaptic cell adhesion molecule neuroligin-3 in parvalbumin interneurons causes a decrease in NMDA-receptor-mediated postsynaptic currents and an increase in presynaptic glutamate release probability by selectively impairing the inhibition of glutamate release by presynaptic Group III metabotropic glutamate receptors...
January 9, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28067902/separate-elements-of-episodic-memory-subserved-by-distinct-hippocampal-prefrontal-connections
#7
Gareth R I Barker, Paul J Banks, Hannah Scott, G Scott Ralph, Kyriacos A Mitrophanous, Liang-Fong Wong, Zafar I Bashir, James B Uney, E Clea Warburton
Episodic memory formation depends on information about a stimulus being integrated within a precise spatial and temporal context, a process dependent on the hippocampus and prefrontal cortex. Investigations of putative functional interactions between these regions are complicated by multiple direct and indirect hippocampal-prefrontal connections. Here application of a pharmacogenetic deactivation technique enabled us to investigate the mnemonic contributions of two direct hippocampal-medial prefrontal cortex (mPFC) pathways, one arising in the dorsal CA1 (dCA1) and the other in the intermediate CA1 (iCA1)...
January 9, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28062924/memory-formation-orchestrates-the-wiring-of-adult-born-hippocampal-neurons-into-brain-circuits
#8
Petnoi Petsophonsakul, Kevin Richetin, Trinovita Andraini, Laurent Roybon, Claire Rampon
During memory formation, structural rearrangements of dendritic spines provide a mean to durably modulate synaptic connectivity within neuronal networks. New neurons generated throughout the adult life in the dentate gyrus of the hippocampus contribute to learning and memory. As these neurons become incorporated into the network, they generate huge numbers of new connections that modify hippocampal circuitry and functioning. However, it is yet unclear as to how the dynamic process of memory formation influences their synaptic integration into neuronal circuits...
January 6, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28061973/the-melatonergic-system-in-anxiety-disorders-and-the-role-of-melatonin-in-conditional-fear
#9
F Huang, Z Yang, C-Q Li
BACKGROUND: Resistance to extinction of certain conditioned responses forms the basis of anxieties, phobias, and compulsions. There has been an available effective means of extinction-based exposure psychotherapy for the treatment of anxiety disorders, such as posttraumatic stress disorder (PTSD) that has been hypothesized to result from impaired extinction of fear memory. PTSD is considered as a memory disorder within a Pavlovian fear conditioning and extinction framework. Therefore, the aim of this review was to report the preclinical profile of melatonin, a pineal gland hormone, as a potential pharmacological option in the treatment of anxiety disorders such as PTSD, tested with the Pavlovian fear conditioning paradigm...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28045462/hippocampal-encoding-of-interoceptive-context-during-fear-conditioning
#10
S-W Yoo, M Bae, L B Tovar-Y-Romo, N J Haughey
Rodent models of auditory fear conditioning are often used to understand the molecular mechanisms regulating fear- and anxiety-related behaviors. Conditioning and extinction memories are influenced by contextual cues, and the reinstatement of conditioned fear occurs when the conditioning stimulus is presented in a context different from the extinction context. Although it has been proposed that internal state is a feature of context that could influence extinction, contributions of interoception to conditioning have not been experimentally addressed...
January 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28044046/contextual-and-psychosocial-determinants-of-effective-handwashing-technique-recommendations-for-interventions-from-a-case-study-in-harare-zimbabwe
#11
Max N D Friedrich, Marc E Binkert, Hans-Joachim Mosler
Handwashing has been shown to considerably reduce diarrhea morbidity and mortality. To decontaminate hands effectively, the use of running water, soap, and various scrubbing steps are recommended. This study aims to identify the behavioral determinants of effective handwashing. Everyday handwashing technique of 434 primary caregivers in high-density suburbs of Harare, Zimbabwe, was observed and measured as an 8-point sum score of effective handwashing technique. Multiple linear and logistic regression analyses were performed to predict observed handwashing technique from potential contextual and psychosocial determinants...
January 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28041797/sharp-wave-ripples-in-primates-are-enhanced-near-remembered-visual-objects
#12
Timothy K Leonard, Kari L Hoffman
The hippocampus plays an important role in memory for events that are distinct in space and time. One of the strongest, most synchronous neural signals produced by the hippocampus is the sharp-wave ripple (SWR), observed in a variety of mammalian species during offline behaviors, such as slow-wave sleep [1-3] and quiescent waking and pauses in exploration [4-8], leading to long-standing and widespread theories of its contribution to plasticity and memory during these inactive or immobile states [9-14]. Indeed, during sleep and waking inactivity, hippocampal SWRs in rodents appear to support spatial long-term and working memory [4, 15-23], but so far, they have not been linked to memory in primates...
December 21, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28034785/modulation-of-the-consolidation-and-reconsolidation-of-fear-memory-by-three-different-serotonin-receptors-in-hippocampus
#13
S D Schmidt, C R G Furini, C G Zinn, L E Cavalcante, F F Ferreira, J A K Behling, J C Myskiw, I Izquierdo
The process of memory formation is complex and highly dynamic. During learning, the newly acquired information is found in a fragile and labile state. Through a process known as consolidation, which requires specific mechanisms such as protein synthesis, the memory trace is stored and stabilized. It is known that when a consolidated memory is recalled, it again becomes labile and sensitive to disruption. To be maintained, this memory must undergo an additional process of restabilization called reconsolidation, which requires another phase of protein synthesis...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28034784/altered-ampa-receptor-expression-plays-an-important-role-in-inducing-bidirectional-synaptic-plasticity-during-contextual-fear-memory-reconsolidation
#14
Subhrajit Bhattacharya, Whitney Kimble, Manal Buabeid, Dwipayan Bhattacharya, Jenna Bloemer, Ahmad Alhowail, Miranda Reed, Muralikrishnan Dhanasekaran, Martha Escobar, Vishnu Suppiramaniam
Retrieval of a memory appears to render it unstable until the memory is once again re-stabilized or reconsolidated. Although the occurrence and consequences of reconsolidation have received much attention in recent years, the specific mechanisms that underlie the process of reconsolidation have not been fully described. Here, we present the first electrophysiological model of the synaptic plasticity changes underlying the different stages of reconsolidation of a conditioned fear memory. In this model, retrieval of a fear memory results in immediate but transient alterations in synaptic plasticity, mediated by modified expression of the glutamate receptor subunits GluA1 and GluA2 in the hippocampus of rodents...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28025067/dopamine-d1-like-receptor-in-lateral-habenula-nucleus-affects-contextual-fear-memory-and-long-term-potentiation-in-hippocampal-ca1-in-rats
#15
Jiangping Chan, Xin Guan, Yiling Ni, Lilu Luo, Liqiang Yang, Pengyue Zhang, Jichuan Zhang, Yanmei Chen
The Lateral Habenula (LHb) plays an important role in emotion and cognition. Recent experiments suggest that LHb has functional interaction with the hippocampus and plays an important role in spatial learning. LHb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (VTA). However, the role of dopamine type 1 receptor (D1R) in LHb in learning and memory is not clear yet. In the present study, D1R agonist or antagonist were administered bilaterally into the LHb in rats...
December 23, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28024879/dynamic-representations-of-visual-space-for-perception-and-action
#16
REVIEW
W Pieter Medendorp, Anouk J de Brouwer, Jeroen B J Smeets
The division of labor in visual processing between two anatomically relatively separate cortical pathways, a ventral and a dorsal stream, has been hotly debated in the last decades. One influential model is the What & How pathway model, suggesting that the separation is along ventral perception versus dorsal action, although the degree of functional separation between the two streams is controversial. An implication of this model is that perception and memory-guided movements are highly sensitive to visual contextual illusions, whereas visually-guided movements are largely immune to them...
November 30, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28018227/bidirectional-effects-of-cannabidiol-on-contextual-fear-memory-extinction
#17
Chenchen Song, Carl W Stevenson, Francisco S Guimaraes, Jonathan L C Lee
Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation. Here, we directly compared the effects of i.p. injections of cannabidiol (10 mg/kg) with those of the NMDA receptor antagonist MK-801 (0.1 mg/kg) and partial agonist D-cycloserine (DCS; 15 mg/kg) in order to determine the mnemonic basis of long-term fear reduction. We showed that under conditions of strong fear conditioning, CBD reduced contextual fear memory expression both acutely during the extinction session as well as later at a fear retention test...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28001126/a-microrna-negative-feedback-loop-downregulates-vesicle-transport-and-inhibits-fear-memory
#18
Rebecca S Mathew, Antonis Tatarakis, Andrii Rudenko, Erin M Johnson-Venkatesh, Yawei J Yang, Elisabeth A Murphy, Travis P Todd, Scott T Schepers, Nertila Siuti, Anthony J Martorell, William A Falls, Sayamwong E Hammack, Christopher A Walsh, Li-Huei Tsai, Hisashi Umemori, Mark E Bouton, Danesh Moazed
The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling associated with formation of long-term memories, but the mechanisms that regulate this pathway during memory acquisition are not fully understood. Here we identify miRNAs that are up-regulated in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular transport and synaptogenesis pathways as the major targets of the fear-induced miRNAs. We demonstrate that miR-153, a member of this group, inhibits the expression of key components of the vesicular transport machinery, and down-regulates Glutamate receptor A1 trafficking and neurotransmitter release...
December 21, 2016: ELife
https://www.readbyqxmd.com/read/27987416/tissue-resident-memory-t-cells-and-viral-immunity
#19
REVIEW
Pamela C Rosato, Lalit K Beura, David Masopust
Tissue resident memory T cells (TRM) constitute a recently identified T cell lineage that is responsible for frontline defense against viral infections. In contrast to central and effector memory T cells, which constitutively recirculate between tissues and blood, TRM reside permanently within tissues. As the main surveyors of non-lymphoid tissues, TRM are positioned to rapidly respond upon reinfection at barrier sites. During a viral reinfection, TRM trigger the local tissue environment to activate and recruit immune cells and establish an antiviral state...
December 14, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27980075/effects-of-context-preexposure-and-delay-until-anxiety-retrieval-on-generalization-of-contextual-anxiety
#20
Marta Andreatta, Dorothea Neueder, Evelyn Glotzbach-Schoon, Andreas Mühlberger, Paul Pauli
Animal studies suggest that time delay between acquisition and retrieval of contextual anxiety increases generalization. Moreover, such generalization is prevented by preexposure to the context (CTX), presumably due to an improved representation of such context. We investigated whether preexposure and time-passing modulate generalization of contextual anxiety, in humans. On Day 1, 42 participants (preexposure group) explored two virtual offices, while 41 participants (no-preexposure group) explored a virtual stadium...
January 2017: Learning & Memory
keyword
keyword
42450
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"