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dHPC inactivation

Patrick K Cullen, T Lee Gilman, Patrick Winiecki, David C Riccio, Aaron M Jasnow
Memories for context become less specific with time resulting in animals generalizing fear from training contexts to novel contexts. Though much attention has been given to the neural structures that underlie the long-term consolidation of a context fear memory, very little is known about the mechanisms responsible for the increase in fear generalization that occurs as the memory ages. Here, we examine the neural pattern of activation underlying the expression of a generalized context fear memory in male C57BL/6J mice...
October 2015: Neurobiology of Learning and Memory
Gaelle Dominguez, Pierre Faucher, Nadia Henkous, Ali Krazem, Christophe Piérard, Daniel Béracochéa
Most of the deleterious effects of stress on memory retrieval are due to a dysfunction of the hippocampo-prefrontal cortex interplay. The role of the stress-induced regional corticosterone increase in such dysfunction remains however unclear, since there is no published study as yet dedicated to measuring corticosterone concentrations simultaneously in both the prefrontal cortex (mPFC) and the hippocampus (dHPC) in relation with memory impairments. To that aim, we first showed in Experiment 1 that an acute stress (3 electric footschocks; 0...
2014: Frontiers in Behavioral Neuroscience
Pia-Kelsey O'Neill, Joshua A Gordon, Torfi Sigurdsson
The rodent medial prefrontal cortex (mPFC) is critical for spatial working memory (SWM), but the underlying neural processes are incompletely understood. During SWM tasks, neural activity in the mPFC becomes synchronized with theta oscillations in the hippocampus, and the strength of hippocampal-prefrontal synchrony is correlated with behavioral performance. However, to what extent the mPFC generates theta oscillations and whether they are also modulated by SWM remains unclear. Furthermore, it is not known how theta oscillations in the mPFC are synchronized with theta oscillations in the hippocampus...
August 28, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Romain Goutagny, Michael Loureiro, Jesse Jackson, Joseph Chaumont, Sylvain Williams, Philippe Isope, Christian Kelche, Jean-Christophe Cassel, Lucas Lecourtier
The lateral habenula (LHb) is an epithalamic structure connected with both the basal ganglia and the limbic system and that exerts a major influence on midbrain monoaminergic nuclei. The current view is that LHb receives and processes cortical information in order to select proper strategies in a variety of behavior. Recent evidence indicates that LHb might also be implicated in hippocampus-dependent memory processes. However, if and how LHb functionally interacts with the dorsal hippocampus (dHPC) is still unknown...
November 2013: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Paul De Saint Blanquat, Vincent Hok, Etienne Save, Bruno Poucet, Franck A Chaillan
Encoding of a goal with a specific value while performing a place navigation task involves the medial prefrontal cortex (mPFC) and the dorsal hippocampus (dHPC), and depends on the coordination between mPFC and the ventro-intermediate hippocampus (vHPC).The present work investigates the contribution of mPFC, dHPC, and vHPC when the rat has to update the value of a goal. Rats were trained to navigate to an uncued goal in order to release a food pellet in a continuous place navigation task. When they had reached criterion performance level in the task, they were subjected to a single "flash session" in which they were exposed to an aversive strobe light during goal visits instead of receiving a food reward...
May 2013: Hippocampus
Taejib Yoon, Jeffrey Okada, Min W Jung, Jeansok J Kim
Both the medial prefrontal cortex (mPFC) and hippocampus are implicated in working memory tasks in rodents. Specifically, it has been hypothesized that the mPFC is primarily engaged in the temporary storage and processing of information lasting from a subsecond to several seconds, while the hippocampal function becomes more critical as the working memory demand extends into longer temporal scales. Although these structures may be engaged in a temporally separable manner, the extent of their contributions in the "informational content" of working memory remains unclear...
March 2008: Learning & Memory
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