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Oxygen toxicity

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https://www.readbyqxmd.com/read/29031115/decolorization-and-detoxification-of-dye-mixture-and-textile-effluent-by-lichen-dermatocarpon-vellereceum-in-fixed-bed-upflow-bioreactor-with-subsequent-oxidative-stress-study
#1
Ashwini N Kulkarni, Anuprita D Watharkar, Niraj R Rane, Byong-Hun Jeon, Sanjay P Govindwar
Navy Blue HE22 (NBHE22), dye mixture and real textile effluent were decolorized and degraded by lichen Dermatocarpon vellereceum. Up-flow bioreactor showed about 80%, 70%, 80% and 65% removal of American dye manufacturer index (ADMI), biological oxygen demand (BOD), total suspended solids (TSS) and total dissolved solids (TDS), respectively of dye mixture at flow rate of 25mlh(-1). The removal of ADMI, BOD, TSS and TDS of real textile effluent were 75%, 65%, 82% and 70%, respectively at flow rate of 30mlh(-1)...
October 10, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29031056/physiological-and-biochemical-responses-of-wheat-triticum-aestivum-l-seedlings-to-three-imidazolium-based-ionic-liquids-in-soil
#2
Yaqi Xu, Jun Wang, Lusheng Zhu, Zhongkun Du, Jinhua Wang, Kai Wei
Ionic liquids (ILs) are considered environmentally friendly solvents and are widely applied in various fields; however, some researchers have noted the toxicity of ILs to plants cultivated in nutrient solution. To evaluate the toxicities of ILs to wheat seedlings in soil, the natural growth environment of plants, a study was performed using three imidazolium-based ionic liquids with different anions: 1-octyl-3-methylimidazolium chloride ([C8mim]Cl), 1-octyl-3-methylimidazolium bromide ([C8mim]Br) and 1-octyl-3-methylimidazolium tetrafluoroborate ([C8mim]BF4)...
September 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/29031050/paraquat-affects-mitochondrial-bioenergetics-dopamine-system-expression-and-locomotor-activity-in-zebrafish-danio-rerio
#3
Xiao H Wang, Christopher L Souders, Yuan H Zhao, Christopher J Martyniuk
The dipyridyl herbicide paraquat induces oxidative stress in cells and is implicated in adult neurodegenerative diseases. However, less is known about paraquat toxicity in early stages of vertebrate development. To address this gap, zebrafish (Danio rerio) embryos were exposed to 1, 10 and 100 μM paraquat for 96 h. Paraquat did not induce significant mortality nor deformity in embryos and larvae, but it did accelerate time to hatch. To evaluate whether mitochondrial respiration was related to earlier hatch times, oxygen consumption rate was measured in whole embryos...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29028546/enzymatic-characterization-and-crystal-structure-analysis-of-chlamydomonas-reinhardtii-dehydroascorbate-reductase-and-their-implications-for-oxidative-stress
#4
Hsin-Yang Chang, Shu-Tseng Lin, Tzu-Ping Ko, Shu-Mei Wu, Tsen-Hung Lin, Yu-Ching Chang, Kai-Fa Huang, Tse-Min Lee
Dehydroascorbate reductase (DHAR) is a key enzyme for glutathione (GSH)-dependent reduction of dehydroascorbate (DHA) to recycled ascorbate (AsA) in plants, and plays a major role against the toxicity of reactive oxygen species (ROS). Previously, we proposed that the increase of AsA regeneration via enhanced DHAR activity modulates the ascorbate-glutathione cycle activity against photooxidative stress in Chlamydomonas reinhardtii. In the present work, we use site-directed mutagenesis and crystal structure analysis to elucidate the molecular basis of how C...
October 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29028541/tuning-the-structure-of-aminoferrocene-based-anticancer-prodrugs-to-prevent-their-aggregation-in-aqueous-solution
#5
Steffen Daum, Svetlana Babiy, Helen Konovalova, Walter Hofer, Alexander Shtemenko, Natalia Shtemenko, Christina Janko, Christoph Alexiou, Andriy Mokhir
Aminoferrocene-based prodrugs are activated in cancer cells by reactive oxygen species (ROS). They were shown to exhibit high cytotoxicity towards a variety of cancer cell lines and primary cancer cells, but remain not toxic towards non-malignant cells. However, these prodrugs have rather high lipophilicity leading to relatively low water solubility. In particular, an n-octanol/water partition coefficient for the best aminoferrocene-based prodrug (2) was found to be 4.51±0.03. Though the approaches for decreasing lipophilicity are straightforward and include the addition of polar residues to the drug structure, these modifications also lead to dramatic decrease of cell permeability and, correspondingly, lower the activity of the drug...
September 15, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29028538/nitric-oxide-induces-rice-tolerance-to-excessive-nickel-by-regulating-nickel-uptake-reactive-oxygen-species-detoxification-and-defense-related-gene-expression
#6
Muhammad Rizwan, Mohammad Golam Mostofa, Muhammad Zulfiqar Ahmad, Muhammad Imtiaz, Sajid Mehmood, Muhammad Adeel, Zhihua Dai, Zheyong Li, Omar Aziz, Yihui Zhang, Shuxin Tu
Soil contamination with nickel (Ni) is a persistent threat to crop production worldwide. The present study examined the putative roles of nitric oxide (NO) in improving Ni-tolerance in rice. Our findings showed that application of exogenous sodium nitroprusside (SNP), a NO donor, significantly improved the growth performance of rice seedlings when grown under excessive Ni. The enhanced Ni-tolerance of rice prompted by SNP could be ascribed to its ability to regulate Ni uptake, decrease Ni-induced oxidative stress as evidenced by reduced levels of hydrogen peroxide, malondialdehyde, and electrolyte leakage in Ni-stressed plants...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#7
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025643/comb-shaped-temperature-tunable-and-water-soluble-porphyrin-based-thermoresponsive-copolymer-for-enhanced-photodynamic-therapy
#8
Changling Liu, Yanhui Li, Bo Gao, Yanwei Li, Qian Duan, Toyoji Kakuchi
A novel comb-shaped porphyrin end-functionalized poly(N-isopropylacrylamide)-b-poly[oligo (ethylene glycol methyl ether methacrylate)] (Por-PNIPAM-b-POEGMA) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the incorporation of hydrophilic POEGMA contents, the copolymer shows the lower critical solution temperatures (LCST) of 37-41.8°C higher than PNIPAM. Moreover, this copolymer showed efficient singlet oxygen under light irradiation at 650nm, and the productivity of singlet oxygen was 0...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024968/iron-suppresses-ovarian-granulosa-cell-proliferation-and-arrests-cell-cycle-through-regulating-p38-mapk-p53-p21-pathway
#9
Mei-Jou Chen, Chia-Hong Chou, Chia-Tung Shun, Tsui-Lien Mao, Wen-Fen Wen, Chin-Der Chen, Shee-Uan Chen, Yu-Shih Yang, Hong-Nerng Ho
Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferation and arrested the cell cycle at the G2/M phase by cell proliferation assay and flow cytometry...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29022894/adiponectin-controls-the-apoptosis-and-the-expression-of-tight-junction-proteins-in-brain-endothelial-cells-through-adipor1-under-beta-amyloid-toxicity
#10
Juhyun Song, Seong-Min Choi, Daniel J Whitcomb, Byeong C Kim
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by excessive beta amyloid (Aβ) deposition in brain, leading to blood-brain barrier (BBB) disruption. The mechanisms of BBB disruption in AD are still unclear, despite considerable research. The adipokine adiponectin is known to regulate various metabolic functions and reduce inflammation. Though adiponectin receptors have been reported in the brain, its role in the central nervous system has not been fully characterized. In the present study, we investigate whether adiponectin contributes to the tight junction integrity and cell death of brain endothelial cells under Aβ-induced toxicity conditions...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022370/toxicity-and-immunomodulatory-efficacy-of-biosynthesized-silver-myconanosomes-on-pathogenic-microbes-and-macrophage-cells
#11
Faria Fatima, Neelam Pathak, Smita Rastogi Verma, Preeti Bajpai
Silver myconanosomes prepared from Alternaria brassicae may exhibit potential antimicrobial and immunomodulatory activity due to their inimitable character. The prepared myconanosomes were characterized by using differential light scattering, zeta potential, UV-visible spectroscopy and transmission electron microscopic analyses. Mycologically produced AgNPs were found as spherical and irregular shaped measuring size range between 55.4 and 70.23 nm. The antimicrobicidal activity of these AgNPs against pathogenic microbes was evaluated by agar well diffusion method...
October 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29022339/resveratrol-ameliorates-tau-hyperphosphorylation-at-ser396-site-and-oxidative-damage-in-rat-hippocampal-slices-exposed-to-vanadate-implication-of-erk1-2-and-gsk-3%C3%AE-signaling-cascades
#12
Kyoung A Jhang, Jin-Sun Park, Hee-Sun Kim, Young Hae Chong
The objective of this study was to investigate the effect of resveratrol (a natural polyphenolic phytostilbene) on tau hyperphosphorylation and oxidative damage induced by sodium orthovanadate (Na3VO4), the prevalent species of vanadium (vanadate), in rat hippocampal slices. Our results showed that resveratrol significantly inhibited Na3VO4-induced hyperphosphorylation of tau at Ser396 (p-S396-tau) site, which is upregulated in the hippocampus of Alzheimer's disease (AD) brains and principally linked to AD-associated cognitive dysfunction...
October 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29022246/alpha-lipoic-acid-mitigates-toxic-induced-demyelination-in-the-corpus-callosum-by-lessening-of-oxidative-stress-and-stimulation-of-polydendrocytes-proliferation
#13
Nima Sanadgol, Fereshteh Golab, Hassan Askari, Fatemeh Moradi, Marziyeh Ajdary, Mehdi Mehdizadeh
Multiple Sclerosis (MS), is a disease that degenerates myelin in central nervous system (CNS). Reactive oxygen species (ROSs) are toxic metabolites, and accumulating data indicate that ROSs-mediated apoptosis of oligodendrocytes (OLGs) plays a major role in the pathogenesis of MS under oxidative stress conditions. In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS...
October 12, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29021790/ammonia-oxidation-and-nitrite-reduction-in-the-verrucomicrobial-methanotroph-methylacidiphilum-fumariolicum-solv
#14
Sepehr S Mohammadi, Arjan Pol, Theo van Alen, Mike S M Jetten, Huub J M Op den Camp
The Solfatara volcano near Naples (Italy), the origin of the recently discovered verrucomicrobial methanotroph Methylacidiphilum fumariolicum SolV was shown to contain ammonium ([Formula: see text]) at concentrations ranging from 1 to 28 mM. Ammonia (NH3) can be converted to toxic hydroxylamine (NH2OH) by the particulate methane monooxygenase (pMMO), the first enzyme of the methane (CH4) oxidation pathway. Methanotrophs rapidly detoxify the intermediate NH2OH. Here, we show that strain SolV performs ammonium oxidation to nitrite at a rate of 48...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29020640/bridging-spatially-segregated-redox-zones-with-a-microbial-electrochemical-snorkel-triggers-biogeochemical-cycles-in-oil-contaminated-river-tyne-uk-sediments
#15
Carolina Cruz Viggi, Bruna Matturro, Emanuela Frascadore, Susanna Insogna, Alessio Mezzi, Saulius Kaciulis, Angela Sherry, Obioma K Mejeha, Ian M Head, Eleni Vaiopoulou, Korneel Rabaey, Simona Rossetti, Federico Aulenta
Marine sediments represent an important sink for a number of anthropogenic organic contaminants, including petroleum hydrocarbons following an accidental oil spill. Degradation of these compounds largely depends on the activity of sedimentary microbial communities linked to biogeochemical cycles, in which abundant elements such as iron and sulfur are shuttled between their oxidized and reduced forms. Here we show that introduction of a small electrically conductive graphite rod ("the electrochemical snorkel") into an oil-contaminated River Tyne (UK) sediment, so as to create an electrochemical connection between the anoxic contaminated sediment and the oxygenated overlying water, has a large impact on the rate of metabolic reactions taking place in the bulk sediment...
October 3, 2017: Water Research
https://www.readbyqxmd.com/read/29020531/mechanisms-of-antibiotic-resistance-in-bacteria-mediated-by-silver-nanoparticles
#16
Chitrada Kaweeteerawat, Preeyawis Na Ubol, Sanirat Sangmuang, Sasitorn Aueviriyavit, Rawiwan Maniratanachote
Silver nanoparticles (AgNPs) are widely used in industry, consumer products, and medical appliances due to their efficient antimicrobial properties. However, information on environmental toxicity and bacterial impact of these particles is not completely elucidated. Results showed that AgNPs produced growth inhibition and oxidative stress in bacteria Escherichia coli (gram negative) and Staphylococcus aureus (gram positive), with half-maximal inhibitory concentrations (IC50) of 12 and 7 mg/L, respectively. Surprisingly, bacteria pre-exposed to sublethal dose of AgNPs exhibited increased resistance toward antibiotics (ampicillin and Pen-Strep) with IC50 elevated by 3-13-fold...
October 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29019495/a-novel-visible-light-responsive-nanosystem-for-cancer-treatment
#17
M Martínez-Carmona, D Lozano, A Baeza, M Colilla, M Vallet-Regí
A novel singlet-oxygen sensitive drug delivery nanocarrier able to release its cargo after exposure to visible (Vis) light from a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In the presence of Vis light porphyrin-nanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP)...
October 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29019267/ge11-peptide-conjugated-selenium-nanoparticles-for-egfr-targeted-oridonin-delivery-to-achieve-enhanced-anticancer-efficacy-by-inhibiting-egfr-mediated-pi3k-akt-and-ras-raf-mek-erk-pathways
#18
Jiang Pi, Jinhuan Jiang, Huaihong Cai, Fen Yang, Hua Jin, Peihui Yang, Jiye Cai, Zheng W Chen
Selenium nanoparticles (Se NPs) have attracted increasing interest in recent decades because of their anticancer, immunoregulation, and drug carrier functions. In this study, GE11 peptide-conjugated Se NPs (GE11-Se NPs), a nanosystem targeting EGFR over-expressed cancer cells, were synthesized for oridonin delivery to achieve enhanced anticancer efficacy. Oridonin loaded and GE11 peptide conjugated Se NPs (GE11-Ori-Se NPs) were found to show enhanced cellular uptake in cancer cells, which resulted in enhanced cancer inhibition against cancer cells and reduced toxicity against normal cells...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29018231/biochemical-mechanisms-of-dose-dependent-cytotoxicity-and-ros-mediated-apoptosis-induced-by-lead-sulfide-graphene-oxide-quantum-dots-for-potential-bioimaging-applications
#19
Mahdi Ayoubi, Parvaneh Naserzadeh, Mohammad Taghi Hashemi, Mohammad Reza Rostami, Elnaz Tamjid, Mohammad Mahdi Tavakoli, Abdolreza Simchi
Colloidal quantum dots (CQD) have attracted considerable attention for biomedical diagnosis and imaging as well as biochemical analysis and stem cell tracking. In this study, quasi core/shell lead sulfide/reduced graphene oxide CQD with near infrared emission (1100 nm) were prepared for potential bioimaging applications. The nanocrystals had an average diameter of ~4 nm, a hydrodynamic size of ~8 nm, and a high quantum efficiency of 28%. Toxicity assay of the hybrid CQD in the cultured human mononuclear blood cells does not show cytotoxicity up to 200 µg/ml...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017960/upper-respiratory-tract-nociceptor-stimulation-and-stress-response-following-acute-and-repeated-cyfluthrin-inhalation-in-normal-and-pregnant-rats-physiological-rat-specific-adaptions-can-easily-be-misunderstood-as-adversities
#20
Juergen Pauluhn
This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroexcitatory afferent sensory stimulus from peripheral nociceptors in the upper respiratory tract is likely to be perceived as a transient stimulus triggering annoyance and/or avoidance by both rats and humans...
October 7, 2017: Toxicology Letters
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