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https://www.readbyqxmd.com/read/28214754/new-pt-nnso-core-anticancer-agents-structural-optimization-and-investigation-of-their-anticancer-activity
#1
Shu Xian Chong, Yinxue Jin, Steve Chik Fun Au-Yeung, Kenneth Kin Wah To
A series of new platinum Pt(II) compounds possessing a bidentate leaving ligand modified from oxaliplatin has been synthesized, with one of the oxygen ligating atom substituted for a sulphur atom (resulting in a Pt-NNSO coordination core structure). The general structures are R,R-diaminocyclohexane (DACH)-Pt-(methylthio)acetic acid (K4) and DACH-Pt-(thiophenylacetic acid) (K4 derivatives). Substitution of an electron donating or withdrawing group at the ortho or para position on the phenyl ring of K4 derivatives was found to affect the complexes' stability, reactivity with the biological molecules (5'-guanosine monophosphate (5'-GMP) and L-methionine (L-Met)) and anticancer activity...
February 12, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28214608/near-infrared-activatable-phthalocyanine-poly-l-glutamic-acid-conjugate-increased-cellular-uptake-and-light-dark-toxicity-ratio-towards-an-effective-photodynamic-cancer-therapy
#2
Lik Voon Kiew, Hoay Yan Cheah, Siew Hui Voon, Elena Gallon, Julie Movellan, Kia Hui Ng, Serkan Alpugan, Hong Boon Lee, Fabienne Dumoulin, María J Vicent, Lip Yong Chung
In photodynamic therapy (PDT), the low absorptivity of photosensitizers in an aqueous environment reduces singlet oxygen generation efficiency and thereby decreases photosensitizing efficacy in biological conditions. To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate (1-PG) made from a new phthalocyanine (Pc 1) monofunctionalized to allow adequate conjugation to PGA. The resulting 1-PG conjugate retained high absorptivity in the near-infrared (NIR) region at its λmax 675nm in an aqueous environment...
February 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28213827/resistance-to-polycyclic-aromatic-hydrocarbon-toxicity-and-associated-bioenergetic-consequences-in-a-population-of-fundulus-heteroclitus
#3
C D Lindberg, N Jayasundara, J S Kozal, T C Leuthner, R T Di Giulio
Several locations in the Elizabeth River, VA, USA are highly contaminated with polycyclic aromatic hydrocarbons (PAHs) due to the release of creosote mixtures from wood treatment facilities. Interestingly, some populations of Atlantic killifish (Fundulus heteroclitus) inhabiting the Elizabeth River (ER) are resistant to PAH-induced teratogenesis. However, evolutionary resistance to PAHs due to chronic PAH exposure is associated with reduced fitness and increased susceptibility to other environmental stressors in at least one PAH-resistant ER killifish population...
February 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28212704/neurochemical-differences-in-learning-and-memory-paradigms-among-rats-supplemented-with-anthocyanin-rich-blueberry-diets-and-exposed-to-acute-doses-of-56-fe-particles
#4
Shibu M Poulose, Bernard M Rabin, Donna F Bielinski, Megan E Kelly, Marshall G Miller, Nopporn Thanthaeng, Barbara Shukitt-Hale
The protective effects of anthocyanin-rich blueberries (BB) on brain health are well documented and are particularly important under conditions of high oxidative stress, which can lead to "accelerated aging." One such scenario is exposure to space radiation, consisting of high-energy and -charge particles (HZE), which are known to cause cognitive dysfunction and deleterious neurochemical alterations. We recently tested the behavioral and neurochemical effects of acute exposure to HZE particles such as (56)Fe, within 24-48h after exposure, and found that radiation primarily affects memory and not learning...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28212524/role-of-nrf2-and-protective-effects-of-metformin-against-tobacco-smoke-induced-cerebrovascular-toxicity
#5
Shikha Prasad, Ravi K Sajja, Mohammad Abul Kaisar, Jee Hyun Park, Heidi Villalba, Taylor Liles, Thomas Abbruscato, Luca Cucullo
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of developing type-2 diabetes mellitus (2DM) with which it shares other pathogenic traits including the high risk of cerebrovascular and neurological disorders like stroke via ROS generation, inflammation, and blood-brain barrier (BBB) impairment. Herein we provide evidence of the role played by nuclear factor erythroid 2-related factor (Nrf2) in CS-induced cerebrobvascular/BBB impairments and how these cerebrovascular harmful effects can be circumvented by the use of metformin (MF; a widely prescribed, firstline anti-diabetic drug) treatment...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28212011/a-fluorescent-anionic-mof-with-zn4-trz-2-chain-for-highly-selective-visual-sensing-of-contaminants-cr-iii-ion-and-tnp
#6
Xiao-Xia Jia, Ru-Xin Yao, Fu-Qiang Zhang, Xian-Ming Zhang
Heavy-metal ions and nitroaromatic substances are highly toxic and harmful to human health and the ecological environment. It is an urgent issue to selectively detect and capture these toxic substances. By introducing the triazole ligand to the π-conjugated aromatic carboxylate system and borrowing the organic template open framework idea, a stable fluorescent framework [Me2NH2]4[Zn6(qptc)3(trz)4]·6H2O (1) (H4qptc = terphenyl-2,5,2'5'-tetracarboxylic acid, trz = 1,2,4-triazole) has been successfully synthesized, which features Zn4(trz)2 chain-based 3D anionic structure with channels filled by [Me2NH2](+) cations...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28210896/maximum-availability-and-mineralogical-control-of-chromium-released-from-aod-slag
#7
Junguo Li, Bao Liu, Yanan Zeng, Ziming Wang, Zhiyuan Gao
AOD (argon oxygen decarburization) slag is the by-product in the stainless steel refining process. Chromium existing in AOD slag can leach out and probably poses a serious threat to the environment. To assess the leaching toxicity of chromium released from AOD slag, the temperature-dependent maximum availability leaching test was performed. To determine the controlling mineralogical phases of chromium released from AOD slag, a Visual MINTEQ simulation was established based on Vminteq30 and the FactSage 7.0 database...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28210808/change-in-oxygen-consumption-following-inhalation-of-albuterol-in-comparison-with-levalbuterol-in-healthy-adult-volunteers
#8
Manpreet K Virk, Justin Hotz, Robinder G Khemani, Christopher J L Newth, Patrick A Ross
BACKGROUND: Albuterol is the most commonly used β agonist to treat reversible lower airway obstruction. Albuterol contains a racemic mixture of two enantiomers. Levalbuterol contains the single R form enantiomer. Levalbuterol is frequently prescribed to limit cardiovascular toxicity. OBJECTIVE: We examined changes in oxygen consumption (V'O2) and heart rate (HR) following administration of albuterol and levalbuterol. METHODS: This is a prospective, randomized, single-blinded, controlled study of healthy adult volunteers...
February 16, 2017: Lung
https://www.readbyqxmd.com/read/28209994/reversal-of-the-apoptotic-resistance-of-non-small-cell-lung-carcinoma-towards-trail-by-natural-product-toosendanin
#9
Xin Li, Ming You, Yong-Jian Liu, Lin Ma, Pei-Pei Jin, Ri Zhou, Zhao-Xin Zhang, Baojin Hua, Xiao-Jun Ji, Xiao-Ying Cheng, Fangzhou Yin, Yan Chen, Wu Yin
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively triggers cancer cell death via its association with death receptors on the cell membrane, but exerts negligible side effects on normal cells. However, some non-small-cell lung carcinoma (NSCLC) patients exhibited resistance to TRAIL treatment in clinical trials, and the mechanism varies. In this study, we described for the first time that toosendanin (TSN), a triterpenoid derivative used in Chinese medicine for pain management, could significantly sensitize human primary NSCLC cells or NSCLC cell lines to TRAIL-mediated apoptosis both in vitro and in vivo, while showing low toxicity against human primary cells or tissues...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209544/sestrin2-protects-against-acetaminophen-induced-liver-injury
#10
Seung Jung Kim, Kyu Min Kim, Ji Hye Yang, Sam Seok Cho, Sang Kyu Lee, Sae Kwang Ku, Il Je Cho, Sung Hwan Ki
Acetaminophen (APAP) overdose accounts for half of the cases of acute liver failure worldwide. We previously reported that that Sestrin2 (Sesn2) protects against d-galactosamine/lipopolysaccharide-induced acute fulminant liver failure. In this study, we demonstrated that Sesn2 protects APAP-induced liver injury in mice, using a recombinant adenovirus encoding Sesn2 (Ad-Sesn2). First, we found that treatment of mice with toxic levels of APAP significantly reduced Sesn2 expression. Tail-vein injection with Ad-Sesn2 inhibited APAP-induced serum alanine aminotransferase and aspartate aminotransferase levels and markedly reduced hepatocyte degeneration and inflammatory cell infiltration...
February 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28209268/inorganic-mercury-prevents-the-differentiation-of-sh-sy5y-cells-amyloid-precursor-protein-microtubule-associated-proteins-and-ros-as-potential-targets
#11
Miguel Chin Chan, Elizabeth Bautista, Isabel Alvarado-Cruz, Betzabet Quintanilla-Vega, José Segovia
Exposure to mercury (Hg) occurs through different pathways and forms including methylmecury (MeHg) from seafood and rice, ethylmercury (EtHg), and elemental Hg (Hg(0)) from dental amalgams and artisanal gold mining. Once in the brain all these forms are transformed to inorganic Hg (I-Hg), where it bioaccumulates and remains for long periods. Hg is a well-known neurotoxicant, with its most damaging effects reported during brain development, when cellular key events, such as cell differentiation take place. A considerable number of studies report an impairment of neuronal differentiation due to MeHg exposure, however the effects of I-Hg, an important form of Hg found in brain, have received less attention...
February 6, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28208701/excitotoxins-mitochondrial-and-redox-disturbances-in-multiple-sclerosis
#12
REVIEW
Cecilia Rajda, Dániel Pukoli, Zsuzsanna Bende, Zsófia Majláth, László Vécsei
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). There is increasing evidence that MS is not only characterized by immune mediated inflammatory reactions, but also by neurodegenerative processes. There is cumulating evidence that neurodegenerative processes, for example mitochondrial dysfunction, oxidative stress, and glutamate (Glu) excitotoxicity, seem to play an important role in the pathogenesis of MS. The alteration of mitochondrial homeostasis leads to the formation of excitotoxins and redox disturbances...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208642/photoluminescent-gold-nanoclusters-in-cancer-cells-cellular-uptake-toxicity-and-generation-of-reactive-oxygen-species
#13
Marija Matulionyte, Dominyka Dapkute, Laima Budenaite, Greta Jarockyte, Ricardas Rotomskis
In recent years, photoluminescent gold nanoclusters have attracted considerable interest in both fundamental biomedical research and practical applications. Due to their ultrasmall size, unique molecule-like optical properties, and facile synthesis gold nanoclusters have been considered very promising photoluminescent agents for biosensing, bioimaging, and targeted therapy. Yet, interaction of such ultra-small nanoclusters with cells and other biological objects remains poorly understood. Therefore, the assessment of the biocompatibility and potential toxicity of gold nanoclusters is of major importance before their clinical application...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207828/the-wide-spectrum-high-biocidal-potency-of-bioxy-formulation-when-dissolved-in-water-at-different-concentrations
#14
Dori Dagher, Ken Ungar, Richard Robison, Fadi Dagher
Traditional surface disinfectants that have long been applied in medicine, animal husbandry, manufacturing and institutions are inconvenient at best and dangerous at worst. Moreover, some of these substances have adverse environmental impacts: for example, quaternary ammonium compounds ("quats") are reproductive toxicants in both fish and mammals. Halogens are corrosive both to metals and living tissues, are highly reactive, can be readily neutralized by metals, and react with organic matter to form toxic, persistent by-products such as dioxins and furans...
2017: PloS One
https://www.readbyqxmd.com/read/28207234/potassium-iodide-potentiates-broad-spectrum-antimicrobial-photodynamic-inactivation-using-photofrin
#15
Liyi Huang, Grzegorz Szewczyk, Tadeusz Sarna, Michael R Hamblin
It is known that non-cationic porphyrins such as Photofrin (PF) are effective in mediating antimicrobial photodynamic inactivation (aPDI) of Gram-positive bacteria or fungi. However the aPDI activity of PF against Gram-negative bacteria is accepted to be extremely low. Here we report that the non-toxic inorganic salt, potassium iodide (KI) at a concentration of 100mM when added to microbial cells (10(8)/mL) + PF (10µM hematoporphyrin equivalent) + 415nm light (10J/cm2) can eradicate (>6 logs killing) five different Gram-negative species (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Acinetobacter baumannii), while no killing was obtained without KI...
February 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28205400/design-features-for-optimization-of-tetrapyrrole-macrocycles-as-antimicrobial-and-anticancer-photosensitizers
#16
EDITORIAL
Alejandra Martinez De Pinillos Bayona, Pawel Mroz, Connor Thunshelle, Michael R Hamblin
Photodynamic therapy (PDT) uses non-toxic dyes called photosensitizers (PS) and harmless visible light that combine to form highly toxic reactive oxygen species that kill cells. Originally, a cancer therapy, PDT, now includes applications for infections. The most widely studied PS are tetrapyrrole macrocycles including porphyrins, chlorins, bacteriochlorins, and phthalocyanines. The present review covers the design features in PS that can work together to maximize the PDT activity for various disease targets...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28202243/potential-toxicity-of-ionic-liquid-c12mim-bf4-on-the-growth-and-biochemical-characteristics-of-a-marine-diatom-phaeodactylum-tricornutum
#17
Xiang-Yuan Deng, Da Li, Ling Wang, Xiao-Li Hu, Jie Cheng, Kun Gao
Recently, some researchers have pointed out that the threats of ionic liquids (ILs) to aquatic environment cannot be ignored. Thus, this study investigated the potential toxicity of 1-dodecyl-3-methylimidazolium tetrafluoroborate ([C12mim]BF4) on a marine diatom Phaeodactylum tricornutum at population, biochemical and physiological levels using 96h growth tests with a batch-culture system. Results showed that [C12mim]BF4 was very stable in aquatic environment during 96h of exposure. The growth of P. tricornutum was significantly inhibited by [C12mim]BF4 with 24, 48, 72 and 96h EC50 values of 0...
February 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28199865/non-photochemical-production-of-singlet-oxygen-via-activation-of-persulfate-by-carbon-nanotubes
#18
Xin Cheng, Hongguang Guo, Yongli Zhang, Xiao Wu, Yang Liu
The reaction between persulfate (PS) and carbon nanotubes (CNTs) for the degradation of 2,4-dichlorophenol (2,4-DCP) was investigated. It was demonstrated that CNTs could efficiently activate PS for the degradation of 2,4-DCP. Results suggested that the neither hydroxyl radical (OH) nor sulfate radical (SO4(-)) was produced therein. For the first time, the generation of singlet oxygen ((1)O2) was proved by several methods including electron paramagnetic resonance spectrometry (EPR) and liquid chromatography mass spectrometry measurements...
February 8, 2017: Water Research
https://www.readbyqxmd.com/read/28199748/daylight-photodynamic-therapy-with-methylene-blue-in-plane-warts-a-randomized-double-blind-placebo-controlled-study
#19
G Fathy, M K Asaad, H M Rashid
Photodynamic therapy (PDT) is a technique that utilizes reactive oxygen species produced by a non-toxic dye or photosensitizer molecule in the presence of low intensity visible light to kill mammalian or microbial cells ((1)) . The advantages of PDT are numerous, it is a safe, non-invasive technique which yields effective therapeutic results ((2)) . Photodynamic therapy is not free of adverse effects. The most common one is pain during illumination. With the use of portable light sources to optimize the procedure and facilitate outpatient treatment, the concept of ambulatory PDT has emerged...
February 15, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28198743/a-retrospective-analysis-of-adverse-events-in-hyperbaric-oxygen-therapy-2012-2015-lessons-learned-from-1-5-million-treatments
#20
Hanna Jokinen-Gordon, Richard C Barry, Beckie Watson, D Scott Covington
OBJECTIVE: To describe the distribution and occurrence of adverse events recorded during hyperbaric oxygen (HBO) therapy from 2012 to 2015. In this analysis, events are defined as otic/sinus barotrauma, confinement anxiety, hypoglycemia, oxygen toxicity, pneumothorax, seizure, and shortness of breath. DATA AND ANALYSIS: The data for the analysis were drawn from a proprietary electronic health data system that contained information on 1,529,859 hyperbaric treatments administered during 53,371 treatment courses from 2012 to 2015 in outpatient wound care centers across the United States managed by Healogics, Inc, Jacksonville, Florida...
March 2017: Advances in Skin & Wound Care
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