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https://www.readbyqxmd.com/read/29243919/zinc-ii-metalated-porphyrins-as-photothermogenic-photosensitizers-for-cancer-photodynamic-photothermal-synergistic-therapy
#1
Kaikai Ding, Ye-Wei Zhang, Weili Si, Xiangmin Zhong, Yu Cai, Jianhua Zou, Jinjun Shao, Zhou Yang, Xiaochen Dong
Porphyrin derivatives are the first-generation photosensitizers, and to design a strong NIR-absorbing porphyrin with good water solubility is highly desired for better therapeutic effect to treat tumors. Herein, three new porphyrin derivatives, 5,10,15,20-tetrakis(3,4- dimethoxyphenyl) porphyrin (P1), 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) Zinc porphyrin (ZnP1), and 5,15-bis (3,4-dimethoxyphenyl)-10,20-bis ((4-methoxyphenyl)ethynyl) Zinc porphyrin (ZnP2) have been synthesized. Among them, ZnP2 shows the longest and most intensive Q-bands in the near-infrared (NIR) region, as endows it the strongest light-harvesting capability and deepest tumor tissue penetration...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243759/an-insight-into-the-photodynamic-approach-versus-copper-formulations-in-the-control-of-pseudomonas-syringae-pv-actinidiae-in-kiwi-plants
#2
Vânia Jesus, Diana Martins, Tatiana Branco, Nádia Valério, Maria G P M S Neves, Maria A F Faustino, Luís Reis, Esther Barreal, Pedro P Gallego, Adelaide Almeida
In the last decade, the worldwide production of kiwi fruit has been highly affected by Pseudomonas syringae pv. actinidiae (Psa), a phytopathogenic bacterium; this has led to severe economic losses that are seriously affecting the kiwi fruit trade. The available treatments for this disease are still scarce, with the most common involving frequently spraying the orchards with copper derivatives, in particular cuprous oxide (Cu2O). However, these copper formulations should be avoided due to their high toxicity; therefore, it is essential to search for new approaches for controlling Psa...
December 15, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29241325/nanoscale-organic-inorganic-hybrid-photosensitizer-for-highly-effective-photodynamic-cancer-therapy
#3
Jia Chen, Yu Xu, Yu Gao, Dongliang Yang, Fei Wang, Lei Zhang, Biqing Bao, Lianhui Wang
Recently, photodynamic therapy (PDT) has attracted significant attention as a minimally invasive approach for cancer treatment. Clinical applications of current photosensitizers are often limited by their poor water solubility, low singlet oxygen (1O2) quantum yields, long-term toxicity, instability and complex nanostructures. Here we report a rational design of polyhedral oligomeric silsesquioxanes (POSS)-based porphyrin (PPP5000) used as intrinsically nanoscale photosensitizer. In this strategy, inorganic 3D rigid block POSS not only act as anti-aggregate units but also provide conjugating reactive sites for further chemical modification...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29241238/hyperbaric-oxygen-associated-seizure-leading-to-stroke
#4
Jordan M Warchol, Jeffrey S Cooper, Thomas S Diesing
Oxygen toxicity seizures are a well-known complication of hyperbaric oxygen treatment (HBOT). Until now, there have not been any reported cases of an acute ischaemic event (stroke) as the result of a HBOT-associated oxygen toxicity seizure. We report an event in which a seizure and stroke occurred together and consider that the stroke may have been caused by seizure-induced demand ischaemia. This challenges the generally held view that oxygen toxicity seizures in the clinical hyperbaric setting are benign. A discussion of the literature on the subject of seizure-induced brain injury is included...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241122/modulation-by-neighboring-cells-of-the-responses-and-fate-of-melanoma-cells-irradiated-with-uva
#5
Aleksandra Krzywon, Maria Widel, Krzysztof Fujarewicz, Magdalena Skonieczna, Joanna Rzeszowska-Wolny
UVA radiation, which accounts for about 95% of the solar spectrum, contributes to and may be the etiological factor of skin cancers of which malignant melanoma is the most aggressive. UVA causes oxidative stress in various types of cells in the skin, keratinocyte, melanocytes, and fibroblasts, which is responsible for its cytotoxic effect. Here we used a transwell system to explore how the responses of melanoma cells to a low dose of UVA (20kJ/m2, ~10% of the minimal erythema dose) are influenced by neighboring co-cultured melanoma cells or fibroblasts...
December 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29240674/evaluation-of-the-cytotoxicity-and-genotoxicity-of-flavonolignans-in-different-cellular-models
#6
Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński, Joanna Saluk-Bijak
Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective action, silymarin flavonolignans have many other healthy properties, such as anti-platelet and anti-inflammatory actions. The aim of this study was to evaluate the toxic effect of flavonolignans on blood platelets, peripheral blood mononuclear cells (PBMCs) and human lung cancer cell line-A549-using different molecular techniques...
December 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29238463/protective-effect-of-metformin-on-toxicity-of-butyric-acid-and-arsenic-in-isolated-liver-mitochondria-and-langerhans-islets-in-male-mice-an-in-vitro-study
#7
Akram Ahangarpour, Leila Zeidooni, Mohsen Rezaei, Soheila Alboghobeish, Azin Samimi, Ali Akbar Oroojan
Objectives: Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitochondria were isolated by adopting different centrifugation methods and pancreatic islets isolated by a collagenase method...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238386/optimized-sopungsunkiwon-a-herbal-formula-attenuates-a%C3%AE-oligomer-induced-neurotoxicity-in-alzheimer-s-disease-models
#8
Jin Gyu Choi, Sun Yeou Kim, Jong Woo Kim, Myung Sook Oh
Alzheimer's disease (AD), the most common form of dementia, is an age-related neurodegenerative disease that is characterized by memory dysfunction, neuronal cell damage, and neuroinflammation. It is believed that AD-related pathology is mostly due to the overproduction of Aβ, especially the oligomeric form (AβO), in the brain. Evidence of the effects of multifunctional medicinal herbs in the treatment of AD has been steadily increasing. Optimized-SopungSunkiwon (OSS), a multiherbal formulation that is composed of six medicinal herbs derived from SopungSunkiwon, is a traditional medicine that is prescribed for neurodegenerative disorders in elderly patients...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29236155/oxidative-stress-response-induced-by-butachlor-in-zebrafish-embryo-larvae-the-protective-effect-of-vitamin-c
#9
Qingqing Xiang, Bofan Xu, Yilun Ding, Xiaoyi Liu, Ying Zhou, Farooq Ahmad
The widespread contamination and persistence of the herbicide butachlor in the environment resulted in the exposure of non-target organisms. The present study investigated the toxicity effect of butachlor (1-15 µmol/L) and the protective effect of vitamin C (VC) against butachlor-induced toxicity in zebrafish. It was found that butachlor significantly increased the mortality and malformation rates in a dose-dependent manner, which caused elevation in reactive oxygen species (ROS) and malondialdehyde (MDA) after 72 h exposure...
December 13, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29234668/a-genome-wide-screen-for-fty720-sensitive-mutants-reveals-genes-required-for-ros-homeostasis
#10
Kanako Hagihara, Kanako Kinoshita, Kouki Ishida, Shihomi Hojo, Yoshinori Kameoka, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiura
Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS). Notably, in addition to its well-known mode of action as an S1P modulator, accumulating evidence suggests that FTY720 induces apoptosis in various cancer cells via reactive oxygen species (ROS) generation. Although the involvement of multiple signaling molecules, such as JNK (Jun N-terminal kinase), Akt (alpha serine/threonine-protein kinase) and Sphk has been reported, the exact mechanisms how FTY720 induces cell growth inhibition and the functional relationship between FTY720 and these signaling pathways remain elusive...
November 27, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29234427/a-chinese-herbal-formula-gengnianchun-ameliorates-%C3%AE-amyloid-peptide-toxicity-in-a-caenorhabditis-elegans-model-of-alzheimer-s-disease
#11
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells. Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234084/nonvolatile-bio-memristor-based-on-silkworm-hemolymph-proteins
#12
Lu Wang, Dianzhong Wen
This paper reports the first successful fabrication of an ITO/silkworm hemolymph/Al bio-memristor using silkworm hemolymph as the active layer. Experiments demonstrate that the silkworm hemolymph bio-memristor is a nonvolatile rewritable bipolar memory device with a current switching ratio exceeding 103. The state of the bio-memristor can be retained for more than 104 seconds and remains stable for at least 500 cycles. Tests of 1/f noise have shown that the resistance switching characteristics of the silkworm hemolymph bio-memristor are related to the formation and breaking of conductive filaments, which result from the migration of oxygen ions and the oxidation and reduction of metal cations in the silkworm hemolymph film...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234027/high-efficiency-and-long-term-intracellular-activity-of-an-enzymatic-nanofactory-based-on-metal-organic-frameworks
#13
Xizhen Lian, Alfredo Erazo-Oliveras, Jean-Philippe Pellois, Hong-Cai Zhou
Enhancing or restoring enzymatic function in cells is highly desirable in applications ranging from ex vivo cellular manipulations to enzyme replacement therapies in humans. However, because enzymes degrade in biological milieus, achieving long-term enzymatic activities can be challenging. Herein we report on the in cellulo properties of nanofactories that consist of antioxidative enzymes encapsulated in metal-organic frameworks (MOFs). We demonstrate that, while free enzymes display weak activities for only a short duration, these efficient nanofactories protect human cells from toxic reactive oxygen species for up to a week...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233736/fumonisin-b1-induces-oxidative-stress-in-oesophageal-sno-cancer-cells
#14
René B Khan, Alisa Phulukdaree, Anil A Chuturgoon
Fumonisin B1 (FB1) is a ubiquitous contaminant of maize that is epidemiologically linked to oesophageal cancer (OC) in South Africa. FB1-induced oxidative stress mediates toxicity in animals and human cell lines, but the effects relating to OC are limited. Given the species-specific effects of FB1, this study investigated FB1-mediated toxicity and oxidative stress in spindle-shaped N-cadherin (+) CD45 (-) osteoblastic (SNO) cells. Following exposure to FB1 (0-20 μM) for 48 h, mitochondrial membrane potential and intracellular reactive oxygen species (iROS) were measured (flow cytometry)...
December 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29233008/non-polar-compounds-of-persian-gulf-sea-cucumber-holothuria-parva-selectively-induce-toxicity-on-skin-mitochondria-isolated-from-animal-model-of-melanoma
#15
Yalda Arast, Nina Seyed Razi, Melika Nazemi, Enayatollah Seydi, Jalal Pourahmad
PURPOSE: Melanoma is a highly aggressive and deadly cancer with a poor prognosis given its drug resistance. A defect in apoptosis is one of the key mechanisms that contribute to drug resistance in Melonama. An important sea marine animal is the Holothuria parva, also known as the sea cucumber, which has various pharmacological activities. Compounds obtained from sea cucumbers have shown to have anticancer activity through induction of apoptosis singling. MATERIALS AND METHODS: In the present study, selective toxicity and apoptotic effect of three extracts of Holothuria parva (H...
December 12, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29232825/galectin-1-inhibitor-otx008-induces-tumor-vessel-normalization-and-tumor-growth-inhibition-in-human-head-and-neck-squamous-cell-carcinoma-models
#16
Nathan A Koonce, Robert J Griffin, Ruud P M Dings
Galectin-1 is a hypoxia-regulated protein and a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Here we assessed the ability of non-peptidic galectin-1 inhibitor OTX008 to improve tumor oxygenation levels via tumor vessel normalization as well as tumor growth inhibition in two human HNSCC tumor models, the human laryngeal squamous carcinoma SQ20B and the human epithelial type 2 HEp-2. Tumor-bearing mice were treated with OTX008, Anginex, or Avastin and oxygen levels were determined by fiber-optics and molecular marker pimonidazole binding...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232642/feasibility-of-the-uv-aa-process-as-a-pretreatment-approach-for-bioremediation-of-dye-laden-wastewater
#17
Minghui Yang, Bingdang Wu, Qiuhao Li, Xiaofeng Xiong, Haoran Zhang, Yu Tian, Jiawen Xie, Ping Huang, Suo Tan, Guodong Wang, Li Zhang, Shujuan Zhang
Biodegradability and toxicity are two important indexes in considering the feasibility of a chemical process for environmental remediation. The acetylacetone (AA) mediated photochemical process has been proven as an efficient approach for dye decolorization. Both AA and its photochemical degradation products had a high bioavailability. However, the biocompatibility and ecotoxicology of the UV/AA treated solutions are unclear yet. In the present work, we evaluated the biocompatibility and toxicity of the UV/AA treated solutions at both biochemical and organismal levels...
December 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29232278/low-dose-oxygen-therapy-in-copd-patients-are-there-any-radiation-like-risks
#18
Vivek N Iyer
PURPOSE OF REVIEW: Low-dose oxygen (LDO) supplementation is used by millions of COPD patients worldwide. The therapeutic benefits of LDO supplementation are well known. There are also several concerns regarding the potential for cellular harm from LDO in COPD patients. This review summarizes the current arguments and evidence pertaining to this important topic. RECENT FINDINGS: LDO therapy has been used in COPD patients for more than 50 years. Over the years, data from randomized controlled trials has confirmed that LDO provides survival benefit in COPD patients with severe hypoxemia...
December 9, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29232206/bupivacaine-indirectly-potentiates-glutamate-induced-intracellular-calcium-signaling-in-rat-hippocampal-neurons-by-impairing-mitochondrial-function-in-cocultured-astrocytes
#19
Yuan Xing, Nan Zhang, Wei Zhang, Lei-Ming Ren
BACKGROUND: Bupivacaine induces central neurotoxicity at lower blood concentrations than cardiovascular toxicity. However, central sensitivity to bupivacaine is poorly understood. The toxicity mechanism might be related to glutamate-induced excitotoxicity in hippocampal cells. METHODS: The intracellular free Ca concentration ([Ca]i), mitochondrial membrane potential, and reactive oxygen species generation were measured by fluorescence and two-photon laser scanning microscopy in fetal rat hippocampal neurons and astrocytes...
December 12, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29230019/metabolic-profiling-of-zebrafish-danio-rerio-embryos-by-nmr-spectroscopy-reveals-multifaceted-toxicity-of-%C3%AE-methylamino-l-alanine-bmaa
#20
Upasana Roy, Laura Conklin, Jürgen Schiller, Jörg Matysik, John P Berry, A Alia
β-methylamino-L-alanine (BMAA) has been linked to several interrelated neurodegenerative diseases. Despite considerable research, specific contributions of BMAA toxicity to neurodegenerative diseases remain to be fully resolved. In the present study, we utilized state-of-the-art high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR), applied to intact zebrafish (Danio rerio) embryos, as a model of vertebrate development, to elucidate changes in metabolic profiles associated with BMAA exposure...
December 11, 2017: Scientific Reports
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