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https://www.readbyqxmd.com/read/29767825/-palliative-sedation-development-and-consensus-of-a-german-language-documentation-template
#1
C Klein, C Wittmann, K N Wendt, C Ostgathe, S Stiel
BACKGROUND: Palliative sedation (PS) serves as a therapeutic option in cases of otherwise intractable suffering. As the use of sedative and hypnotic medication in many diverse situations is a core competency of anesthesiology, anesthesiologists are confronted with questions of sedative therapy at the end of life in institutions for specialized palliative care, in intensive care units and intermediate care wards. In recent years a number of guidelines have been published internationally but so far no official guidelines exist in Germany...
May 16, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29762884/the-use-of-overnight-oximetry-in-neonates-a-literature-review
#2
REVIEW
Anndrea Flint, Mark W Davies
There is much debate between neonatologists and paediatricians about appropriate oxygen saturation targets for babies with chronic neonatal lung disease (CNLD). Overnight oximetry is used to guide the fraction of inspired oxygen to use. We did this literature review to examine the current literature on the use of overnight oximetry in term infants, preterm infants and babies with CNLD (especially relevant to ex-preterm babies with CNLD going home on oxygen). We reviewed the literature from January 1990 to October 2017 by searching the following databases: Cochrane Central Register of Controlled Trials, The Joanna Briggs Institute, CINAHL, MEDLINE, Scopus, EMBASE, ProQuest and Science Direct...
May 15, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29694991/bronchopulmonary-dysplasia-can-we-agree-on-a-definition
#3
Eduardo Bancalari, Deepak Jain
The advances in obstetric and neonatal care over the last half century have resulted in changes in pathophysiology and clinical presentation of bronchopulmonary dysplasia (BPD). In contrast to the original description of BPD by Northway et al as a severe lung injury in relatively mature preterm infants, the most common form of BPD currently is characterized by chronic respiratory insufficiency in extremely preterm infants. This evolution in the presentation of BPD, along with changes in respiratory support strategies such as increased use of nasal cannula oxygen, has presented a unique challenge to find a definition that describes the severity of lung damage and predict the long-term respiratory outcomes with some accuracy...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29664342/downgrading-of-breast-masses-suspicious-for-cancer-by-using-optoacoustic-breast-imaging
#4
Gisela L G Menezes, Ruud M Pijnappel, Carla Meeuwis, Robertus Bisschops, Jeroen Veltman, Philip T Lavin, Marc J van de Vijver, Ritse M Mann
Purpose To assess the ability of optoacoustic (OA) ultrasonography (US) to help correctly downgrade benign masses classified as Breast Imaging Reporting and Data System (BI-RADS) 4a and 4b to BI-RADS 3 or 2. Materials and Methods OA/US technology uses laser light to detect relative amounts of oxygenated and deoxygenated hemoglobin in and around suspicious breast masses. In this prospective, multicenter study, results of 209 patients with 215 breast masses classified as BI-RADS 4a or 4b at US are reported. Patients were enrolled between 2015 and 2016...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29534200/pyraclostrobin-impairs-energetic-mitochondrial-metabolism-and-productive-performance-of-silkworm-lepidoptera-bombycidae-caterpillars
#5
Daniel Nicodemo, Fábio Ermínio Mingatto, Amanda de Carvalho, Paulo Francisco Veiga Bizerra, Marco Aurélio Tavares, Kamila Vilas Boas Balieira, William Cesar Bellini
Silkworm cocoon production has been reduced due to a number of problems other than those inherent in sericulture, such as diseases, malnutrition, and inappropriate management. The use of pesticides in areas surrounding mulberry fields can contaminate these plants and consequently harm caterpillars. The aim of this study was to evaluate whether the application of the fungicide pyraclostrobin in mulberry plants interferes with the mitochondrial bioenergetics and the productive performance of silkworms. Mulberry plants were treated with pyraclostrobin (0, 100, 200, and 300 g ha-1)...
March 9, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29524391/drosophila-globin1-is-required-for-maintenance-of-the-integrity-of-f-actin-based-cytoskeleton-during-development
#6
Renu Yadav, Nisha, Surajit Sarkar
Hemoglobins (Hbs) are evolutionarily conserved small globular proteins with characteristic 3-over-3 α-helical sandwich structure that is typically known as "globin fold". Hbs have been found to be involved in diverse biological functions and the characteristic property of oxygen transportation is relatively a recent adaptation. Drosophila genome possesses three globin genes (glob1, glob2, and glob3) and it was previously reported that adequate expression of glob1 is required for various aspects of development, and also to regulate the cellular level of reactive oxygen species (ROS)...
May 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29477061/development-of-biochemical-sulfide-potential-bsp-test-for-sulfidogenic-biotechnology-application
#7
Lin Chen, To-Hung Tsui, George A Ekama, Hamish R Mackey, Tianwei Hao, Guanghao Chen
The determination of organics biodegradability and corresponding biodegradation kinetics provides valuable information on the optimal design and operation of anaerobic biotechnology especially for sulfidogenesis. This study proposes a deterministic method, i.e. a biochemical sulfide potential (BSP) test, and compares it to the conventional biochemical methane potential (BMP) test in terms of their ability to characterize sulfate-laden organic waste biodegradability. It demonstrated 1.48 times higher degradation of volatile suspended solids (VSS) and 2...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29462148/vocal-development-through-morphological-computation
#8
Yisi S Zhang, Asif A Ghazanfar
The vocal behavior of infants changes dramatically during early life. Whether or not such a change results from the growth of the body during development-as opposed to solely neural changes-has rarely been investigated. In this study of vocal development in marmoset monkeys, we tested the putative causal relationship between bodily growth and vocal development. During the first two months of life, the spontaneous vocalizations of marmosets undergo (1) a gradual disappearance of context-inappropriate call types and (2) an elongation in the duration of context-appropriate contact calls...
February 2018: PLoS Biology
https://www.readbyqxmd.com/read/29404202/positive-end-expiratory-pressure-in-acute-hypoxemic-respiratory-failure-due-to-community-acquired-pneumonia-do-we-need-a-personalized-approach
#9
Valentina Paolini, Paola Faverio, Stefano Aliberti, Grazia Messinesi, Giuseppe Foti, Oriol Sibila, Anna Monzani, Federica De Giacomi, Anna Stainer, Alberto Pesci
Background: Acute respiratory failure (ARF) is a life-threatening complication in patients with community acquired pneumonia (CAP). The use of non-invasive ventilation is controversial. With this prospective, observational study we aimed to describe a protocol to assess whether a patient with moderate-to-severe hypoxemic ARF secondary to CAP benefits, in clinical and laboratoristic terms, from the application of a positive end expiratory pressure (PEEP) + oxygen vs oxygen alone. Methods: Patients who benefit from PEEP application (PEEP-responders) were defined as those with partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO2/FiO2) increase >20% and/or reduction of respiratory distress during PEEP + oxygen therapy compared to oxygen therapy alone...
2018: PeerJ
https://www.readbyqxmd.com/read/29401411/calculating-metabolic-energy-expenditure-across-a-wide-range-of-exercise-intensities-the-equation-matters
#10
Shalaya Kipp, William C Byrnes, Rodger Kram
We compared 10 published equations for calculating energy expenditure from oxygen consumption and carbon dioxide production using data for 10 high-caliber male distance runners over a wide range of running velocities. We found up to a 5.2% difference in calculated metabolic rate between 2 widely used equations. We urge our fellow researchers abandon out-of-date equations with published acknowledgments of errors or inappropriate biochemical/physical assumptions.
February 5, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29296095/free-radical-scavenging-reverses-fructose-induced-salt-sensitive-hypertension
#11
Zachary P Zenner, Kevin L Gordish, William H Beierwaltes
We have previously reported that a moderate dietary supplementation of 20% fructose but not glucose leads to a salt-sensitive hypertension related to increased proximal sodium-hydrogen exchanger activity and increased renal sodium retention. We also found that while high salt increased renal nitric oxide formation, this was retarded in the presence of fructose intake. We hypothesized that at least part of the pathway leading to fructose-induced salt-sensitive hypertension could be due to fructose-induced formation of reactive oxygen species and inappropriate stimulation of renin secretion, all of which would contribute to an increase in blood pressure...
2018: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29295858/hif-1%C3%AE-stabilization-reduces-retinal-degeneration-in-a-mouse-model-of-retinitis-pigmentosa
#12
Lorena Olivares-González, Cristina Martínez-Fernández de la Cámara, David Hervás, José María Millán, Regina Rodrigo
Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by progressive and irreversible loss of vision due to rod and cone degeneration. Evidence suggests that an inappropriate oxygen level could contribute to its pathogenesis. Rod cell death could increase oxygen concentration, reduce hypoxia-inducible factor 1 (HIF-1α) and contribute to cone cell death. The purposes of this study were: 1) to analyze the temporal profile of HIF-1α, its downstream effectors VEGF, endothelin-1 (ET-1), iNOS, and glucose transporter 1 (GLUT1), and neuroinflammation in retinas of the murine model of rd10 ( retinal degeneration 10) mice with RP; 2) to study oxygen bioavailability in these retinas; and 3) to investigate how stabilizing HIF-1α proteins with dimethyloxaloglycine (DMOG), a prolyl hydroxylase inhibitor, affects retinal degeneration, neuroinflammation, and antioxidant response in rd10 mice...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29279366/evaluation-of-safety-and-cost-of-an-open-design-oxygen-mask-in-a-large-community-hospital
#13
Patricia A DeJuilio, Maya B Jenkins, Jeffrey P Huml
BACKGROUND: In our large community hospital, we observed that traditional oxygen masks were sometimes set at an inappropriately low flow. We hoped to eliminate this safety concern through adoption of an open-design oxygen mask. We also hoped that more immediate flow changes would lead to a decrease in medical gas consumption. Finally, by standardizing to one mask, goals were to reduce the cost of oxygen delivery. METHODS: We conducted a retrospective analysis, 12 months before and 12 months after implementation of the open-design oxygen mask...
April 2018: Respiratory Care
https://www.readbyqxmd.com/read/29273582/the-role-of-chloroplasts-in-plant-pathology
#14
REVIEW
Robert G Sowden, Samuel J Watson, Paul Jarvis
Plants have evolved complex tolerance systems to survive abiotic and biotic stresses. Central to these programmes is a sophisticated conversation of signals between the chloroplast and the nucleus. In this review, we examine the antagonism between abiotic stress tolerance (AST) and immunity: we propose that to generate immunogenic signals, plants must disable AST systems, in particular those that manage reactive oxygen species (ROS), while the pathogen seeks to reactivate or enhance those systems to achieve virulence...
April 13, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29230967/the-obesity-factor-how-cardiorespiratory-fitness-is-estimated-more-accurately-in-people-with-obesity
#15
Karsten Königstein, Christopher Klenk, Anja Rossmeissl, Sandra Baumann, Denis Infanger, Benjamin Hafner, Timo Hinrichs, Henner Hanssen, Arno Schmidt-Trucksäss
OBJECTIVE: Cardiopulmonary exercise testing is clinically used to estimate cardiorespiratory fitness (CRF). The relation to total body mass (TBM) leads to an underestimation of CRF in people with obesity and to inappropriate prognostic and therapeutic decisions. This study aimed to determine body composition-derived bias in the estimation of CRF in people with obesity. METHODS: Two hundred eleven participants (58.8% women; mean BMI 35.7 kg/m2 [± 6.94; 20.7-58...
February 2018: Obesity
https://www.readbyqxmd.com/read/29175443/intracellular-tlr22-acts-as-an-inflammation-equalizer-via-suppression-of-nf-%C3%AE%C2%BAb-and-selective-activation-of-mapk-pathway-in-fish
#16
Xu Ding, Yaosi Liang, Wan Peng, Ruozhu Li, Haoran Lin, Yong Zhang, Danqi Lu
TLR22, a typical member of the fish-specific TLRs, is a crucial sensor in virally triggered innate immune signalling retained from natural selection. To elucidate the role of the TLR22-specific signalling cascade mechanism, we provide evidence that the double-stranded (ds) RNA-sensor TLR22 positively regulates the ERK pathway and negatively regulates the JNK, p38 MAP kinase and NF-κB pathway. Here, we show that TLR22 restrains NF-κB activation and IFN (interferon) β and AP-1 (activator protein-1) promoter binding (impairing "primary response" genes (TNF and IL-1)), induces "secondary response" genes (IL-12 and IL-6) and mediates the irregular expression of inflammatory genes...
January 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29156747/lethality-of-inappropriate-plasma-exposure-on-chicken-embryonic-development
#17
Jiao Jiao Zhang, Jin Oh Jo, Do Luong Huynh, Mrinmoy Ghosh, Nameun Kim, Sang Baek Lee, Hak Kyo Lee, Young Sun Mok, Taeho Kwon, Dong Kee Jeong
In this study, we examined the effects of non-thermal dielectric barrier discharge plasma on embryonic development in chicken eggs in order to determine the optimal level of plasma exposure for the promotion of embryonic growth. We exposed developing chicken embryos at either Hamburger-Hamilton (HH) stage 04 or HH 20 to plasma at voltages of 11.7 kV to 27.6 kV. Our results show exposure at 11.7 kV for 1 min promoted chicken embryonic development, but exposure to more duration and intensity of plasma resulted in dose-dependent embryonic death and HH 20 stage embryos survive longer than those at stage HH 04...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29153134/phd-in-the-foxd1-lineage-cells-links-hypoxia-to-inappropriate-nephrogenesis
#18
Tetsuhiro Tanaka
Insufficient oxygenation during pregnancy negatively influences kidney development, which likely serves as a predisposing factor in chronic kidney disease at later stages in life. In this issue of Kidney International, Kobayashi et al. demonstrate that deletion of prolyl hydroxylase 2 and 3, 2 of the major oxygen sensors, in the FoxD1 lineage cells reduces kidney size and inhibits nephrogenesis in mice. Temporospatial expression pattern and studies on additional knockouts suggest the involvement of hypoxia-inducible factor 2...
December 2017: Kidney International
https://www.readbyqxmd.com/read/29136618/hepcidin-in-iron-homeostasis-diagnostic-and-therapeutic-implications-in-type-2-diabetes-mellitus-patients
#19
Sintayehu Ambachew, Belete Biadgo
The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/29118835/classic-cases-revisited-oxygen-in-court-and-the-problem-of-therapeutic-illusion
#20
Piotr Szawarski
Medical science attempts to inform clinical practice. Law is concerned with causality. Intersection of law and medicine at times highlights the shortcomings in the medical approach to causality. Evidence-based medicine is only as good as the process of gathering evidence and this is inherently imperfect as suggested by philosophers. There is a risk of attributing a causal relationship when there is none, which can result in a false belief about an intervention. False beliefs can become entrenched forming a dogma...
August 2017: Journal of the Intensive Care Society
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