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https://www.readbyqxmd.com/read/29135436/defective-synaptic-transmission-causes-disease-signs-in-a-mouse-model-of-juvenile-neuronal-ceroid-lipofuscinosis
#1
Benedikt Grünewald, Maren D Lange, Christian Werner, Aet O'Leary, Andreas Weishaupt, Sandy Popp, David A Pearce, Heinz Wiendl, Andreas Reif, Hans C Pape, Klaus V Toyka, Claudia Sommer, Christian Geis
Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature death. The consequences of CLN3 mutation on the progression of the disease, on neuronal transmission, and on central nervous network dysfunction are poorly understood. We used Cln3 knockout (Cln3(Δex7/8)) mice and found increased anxiety-related behavior and impaired aversive learning as well as markedly affected motor function including disordered coordination...
November 14, 2017: ELife
https://www.readbyqxmd.com/read/29130290/parent-patient-and-health-professional-perspectives-regarding-enteral-nutrition-in-paediatric-oncology
#2
Jennifer Cohen, Claire E Wakefield, Linda C Tapsell, Karen Walton, Richard J Cohn
AIM: Enteral tube feeding (ETF) is an important part of treatment for paediatric cancer patients. Without nutritional therapy, the prevalence of under-nutrition during treatment for childhood cancer may be as high as 50%. To ensure that the appropriate initiation of ETF is optimised, information on the views of key stakeholders regarding ETF is needed. METHODS: In total, 48 interviews were conducted with parents of paediatric cancer patients (n = 20), patients (n = 10) and members of the paediatric oncology health-care team (n = 18)...
November 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29128558/effects-of-35-carbon-dioxide-co2-inhalation-in-patients-with-post-traumatic-stress-disorder-ptsd-a-double-blind-randomized-placebo-controlled-cross-over-trial
#3
Michael Kellner, Christoph Muhtz, Sven Nowack, Irina Leichsenring, Klaus Wiedemann, Alexander Yassouridis
BACKGROUND: In patients with post-traumatic stress disorder (PTSD) two open pilot studies about the effects of 35% carbon dioxide (CO2) exist. One shows an augmented panicogenic and anxiogenic response (Muhtz et al., 2011), the other does not (Talesnik et al. 2007). We further characterized the CO2 reactivity in PTSD using for the first time placebo-controlled and double-blind conditions. METHODS: In 20 patients with PTSD we assessed panic, anxiety, dissociative and PTSD symptoms after a single vital capacity inhalation of 35% CO2 compared to a placebo gas condition in a within-participant cross-over, placebo-controlled, double-blind and randomized design...
October 31, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29120495/father-play-is-it-special
#4
Natasha J Cabrera, Lori Roggman
Both mothers and fathers play with their children, but research on parent-child play interactions is conducted with mothers three times more often than it is with fathers. The articles in this special issue address this gap by focusing on the nature and quality of father-child play, across cultural contexts, and considering whether father play offers something unique and special for early human development, in infancy or early childhood. The studies show that fathers can be just as developmentally supportive as are mothers in terms of being playful and engaged with their children in ways that are related to greater child socioemotional competence, emotion regulation, and vocabulary, and to less aggression, anxiety, and negativity...
November 9, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/29119819/stories-of-survival-children-s-narratives-of-psychosocial-well-being-following-paediatric-critical-illness-or-injury
#5
Joseph C Manning, Pippa Hemingway, Sarah A Redsell
Survival from critical illness can expose children to an array of negative physical and psychological problems. While the perspective of parents and professionals have been well documented, there is limited understanding of how childhood critical care survivors make sense of their experiences in relation to psychosocial well-being. We aimed to explore long-term psychosocial well-being of childhood survivors of critical illness through their stories. A qualitative, exploratory study using serial in-depth interviews was employed...
September 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29117877/post-traumatic-symptomatology-and-compulsions-as-potential-mediators-of-the-relation-between-child-sexual-abuse-and-auditory-verbal-hallucinations
#6
Simon McCarthy-Jones
BACKGROUND: Whilst evidence is mounting that childhood sexual abuse (CSA) can be a cause of auditory verbal hallucinations (AVH), it is unclear what factors mediate this relation. Recent evidence suggests that post-traumatic symptomatology may mediate the CSA-AVH relation in clinical populations, although this hypothesis has not yet been tested in the general population. There is also reason to believe that obsessive ideation could mediate the CSA-AVH relation. AIMS: To test for evidence to falsify the hypotheses that post-traumatic symptomatology, obsessions, compulsions, anxiety and depression mediate the relation between CSA and AVH in a general population sample...
November 9, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29108521/minority-stressors-rumination-and-psychological-distress-in-monozygotic-twins-discordant-for-sexual-minority-status
#7
Liam Timmins, Katharine A Rimes, Qazi Rahman
BACKGROUND: Lesbian, gay, and bisexual (LGB) individuals report higher levels of depression and anxiety than heterosexual people. Genetic factors may be a 'common cause' of sexual minority status and psychological distress. Alternatively, these may be correlated because of non-genetic environmental factors (e.g. minority stressors). This study investigated minority stressors and distress in monozygotic twins discordant for sexual minority status. This design provides a test of the role of non-shared environmental factors while minimizing differences due to genetics...
November 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29102818/pharmacotherapy-for-social-anxiety-disorder-interpersonal-predictors-of-outcome-and-the-mediating-role-of-the-working-alliance
#8
Jonah N Cohen, Deborah A G Drabick, Carlos Blanco, Franklin R Schneier, Michael R Liebowitz, Richard G Heimberg
Social anxiety disorder (SAD) is highly prevalent and associated with high levels of impairment and distress. Therapies for SAD leave many patients symptomatic at the end of treatment, and little is known about predictors or mechanisms of treatment outcome. Given the interpersonal dysfunction fundamental to SAD, this study investigated whether prominent interpersonal features of SAD (submissive behavior, childhood maltreatment, suppression of anger, and depression) predicted attrition and response to pharmacotherapy and whether the working alliance mediated these relationships...
October 27, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29101712/posttraumatic-stress-related-psychological-functioning-in-adult-survivors-of-childhood-cancer
#9
Jennifer Allen, Victoria W Willard, James L Klosky, Chenghong Li, D Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Sean Phipps
PURPOSE: The majority of research examining posttraumatic stress symptoms/disorder (PTSS/PTSD) among adult survivors of childhood cancer has been oriented to cancer, assuming that cancer has been the most traumatic experience in their lives. Whether that assumption is valid, and how it might impact assessment of PTSS, is unknown. METHODS: Survivors in the St. Jude Lifetime Cohort study completed an assessment of PTSS without cancer orientation, global psychological functioning, perceived stress, and cancer-related anxiety...
November 3, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29101603/hypothalamic-pituitary-adrenal-axis-variants-and-childhood-trauma-influence-anxiety-sensitivity-in-south-african-adolescents
#10
Jacqueline S Womersley, Lindi I Martin, Lize van der Merwe, Soraya Seedat, Sian M J Hemmings
Anxiety sensitivity (AS) is characterised by the fear of anxiety-related symptoms and is a risk factor for the development of anxiety-related disorders. We examined whether genetic variation in three stress response genes, CRHR1, NR3C1, and FKBP5, interact with childhood trauma (CT) to predict AS in South African adolescents. Xhosa (n = 634) and Coloured (n = 317) students completed self-report measures of AS and CT, and a total of eighteen polymorphisms within CRHR1, NR3C1, and FKBP5 were genotyped. Differences in AS based on genetic variation and CT were analysed within population and gender groups using multiple linear regression...
November 4, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29096779/predicting-persistent-limited-and-delayed-problematic-cannabis-use-in-early-adulthood-findings-from-a-longitudinal-study
#11
Sherika Hill, Lilly Shanahan, E Jane Costello, William Copeland
OBJECTIVE: To identify risk profiles associated with patterns of problematic cannabis use in early adulthood. METHOD: Data came from 1,229 participants in the Great Smoky Mountains Study, a prospective 20-year cohort study from 1993 to 2015 that is representative of western North Carolina with yearly assessments conducted from ages 9 and 16 years, and assessments at ages 19, 21, 26, and 30 years. Patterns of problematic cannabis use (i.e., DSM-5 cannabis use disorder or daily use) in early adulthood included the following: nonproblematic use in late adolescence (ages 19-21) and early adulthood (ages 26-30); limited problematic use in late adolescence only; persistent problematic use in late adolescence and early adulthood; and delayed problematic use in early adulthood only...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29096778/adult-associations-of-childhood-suicidal-thoughts-and-behaviors-a-prospective-longitudinal-analysis
#12
William E Copeland, David B Goldston, E Jane Costello
OBJECTIVE: Suicidal thoughts and behavior (STBs) have their peak period of onset in adolescence, but little is known about how such behavior is associated with later functioning. The aim of this study is to test whether childhood STBs are related to adult psychiatric, suicidal, and functional outcomes. METHOD: This is a prospective, population-based community study of 1,420 participants assessed with structured interviews up to 7 times in childhood/adolescence (ages 9-16 years; 6,674 observations) for STBs including passive and active ideation, plans, and attempts...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29094067/comorbidities-confounding-the-outcomes-of-surgery-for-third-window-syndrome-outlier-analysis
#13
P Ashley Wackym, Heather T Mackay-Promitas, Shaban Demirel, Gerard J Gianoli, Martin S Gizzi, Dale M Carter, David A Siker
Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors. Study Design: Observational analytic case-control study in a tertiary referral center. Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29090393/child-sexual-abuse-and-negative-affect-as-shared-risk-factors-for-sexual-aggression-and-sexual-hiv-risk-behavior-in-heterosexual-men
#14
Zoё D Peterson, Erick Janssen, David Goodrich, J Dennis Fortenberry, Devon J Hensel, Julia R Heiman
Previous research has suggested that sexually aggressive behavior and sexual HIV risk behavior are associated. Childhood sexual abuse (CSA) is a well-established risk factor for both types of problematic sexual behavior. Negative affect (i.e., anxiety, depression, and anger) is a less well-studied risk factor, but it has been theorized to relate to both sexual aggression and HIV risk behavior. Thus, this study sought to (1) confirm the relationship between sexual aggression and HIV risk behavior, (2) establish CSA and negative affect as shared risk factors for sexual aggression and HIV risk behavior, and (3) evaluate whether negative affect mediates the relationship between CSA and sexual aggression and between CSA and HIV sexual risk in a sample of heterosexual men...
October 31, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29083028/reciprocity-between-parental-psychopathology-and-oppositional-symptoms-from-preschool-to-middle-childhood
#15
Zayra Antúnez, Nuria de la Osa, Roser Granero, Lourdes Ezpeleta
OBJECTIVE: Oppositional defiant disorder (ODD) is a common disorder in preschool children. Evidence indicates that maternal and paternal psychopathology, particularly aggressive behavior and anxious and depressed symptoms, contributes to the development of this disorder. The latest research also suggests that ODD symptoms may exacerbate the mental health problems of parents. Our aim was to establish the existence of a reciprocal association between paternal and maternal psychopathology (aggression, depression, and anxiety) and child ODD at ages 3 and 8, using a longitudinal design in a community sample of preschoolers...
October 30, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29081722/cognitive-behavioral-therapy-for-a-9-year-old-girl-with-disruptive-mood-dysregulation-disorder
#16
Megan E Tudor, Karim Ibrahim, Emilie Bertschinger, Justyna Piasecka, Denis G Sukhodolsky
Disruptive mood dysregulation disorder (DMDD) is a relatively new diagnosis in the field of childhood onset disorders. Characterized by both behavior and mood disruption, DMDD is a purportedly unique clinical presentation with few relevant treatment studies to date. The current case study presents the application of cognitive-behavioral therapy (CBT) for anger and aggression in a 9-year-old girl with DMDD, co-occurring attention deficit hyperactivity disorder (ADHD), and a history of unspecified anxiety disorder...
December 2016: Clinical Case Studies
https://www.readbyqxmd.com/read/29074261/examining-the-relationship-between-higher-educational-attainment-trauma-symptoms-and-internalizing-behaviors-in-child-sexual-abuse-survivors
#17
Kimberly Hardner, Molly R Wolf, Elaine S Rinfrette
The trauma symptoms of child sexual abuse (CSA) survivors don't end with the abuse, or even with the advent of adulthood. Instead, these symptoms can persist into all the realms of a survivor's life, including education, which sets the foundation for career advancement. This retrospective study of adult survivors of childhood sexual abuse (n=260) examined the relationships between trauma symptoms, dissociation, dissociative amnesia, anxiety, depression, sleep problems and higher education attainment. The purpose of this study was to determine if these factors are associated with higher education completion for childhood sexual abuse (CSA) survivors...
October 23, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29073752/rora-polymorphism-interacts-with-childhood-maltreatment-in-determining-anxiety-sensitivity-by-sex-a-preliminary-study-in-healthy-young-adults
#18
Jung-Ah Min, Heon-Jeong Lee, Seung-Hwan Lee, Young-Min Park, Seung-Gul Kang, Young-Gyu Park, Jeong-Ho Chae
Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29071438/predictive-value-of-dysregulation-profile-trajectories-in-childhood-for-symptoms-of-adhd-anxiety-and-depression-in-late-adolescence
#19
B Wang, L G Brueni, C Isensee, T Meyer, N Bock, U Ravens-Sieberer, F Klasen, R Schlack, A Becker, A Rothenberger
We examined whether there are certain dysregulation profile trajectories in childhood that may predict an elevated risk for mental disorders in later adolescence. Participants (N = 554) were drawn from a representative community sample of German children, 7-11 years old, who were followed over four measurement points (baseline, 1, 2 and 6 years later). Dysregulation profile, derived from the parent report of the Strengths and Difficulties Questionnaire, was measured at the first three measurement points, while symptoms of attention deficit hyperactivity disorder (ADHD), anxiety and depression were assessed at the fourth measurement point...
October 25, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29066053/insomnia-heterogeneity-characteristics-to-consider-for-data-driven-multivariate-subtyping
#20
REVIEW
Jeroen S Benjamins, Filippo Migliorati, Kim Dekker, Rick Wassing, Sarah Moens, Tessa F Blanken, Bart H W Te Lindert, Jeffrey Sjauw Mook, Eus J W Van Someren
Meta-analyses and systematic reviews have reported surprisingly few consistent insomnia-characteristics with respect to cognitions, mood, traits, history of life events and family history. One interpretation of this limited consistency is that different subtypes of insomnia exist, each with its own specific multivariate profile of characteristics. Because previously unrecognized subtypes will be differentially represented in individual studies and dilute effect sizes of subtype-dependent characteristics of importance, they are unlikely to be reported consistently in individual studies, let alone in meta-analyses...
November 9, 2016: Sleep Medicine Reviews
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