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https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#1
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28231241/hydrocephalus-and-arthrogryposis-in-an-immunocompetent-mouse-model-of-zika-teratogeny-a-developmental-study
#2
Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. When injected via the jugular vein into the blood of pregnant females harboring conceptuses from early gastrulation to organogenesis stages, akin to the human second and fifth week of pregnancy, ZIKV infects maternal tissues, placentas and embryos/fetuses...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28229898/histomorphometric-characterization-of-subgemmal-neurogenous-plaques
#3
Ana Carolina Amorim Pellicioli, Felipe Paiva Fonseca, Rodrigo Neves Silva, Luiz Alcino Monteiro Gueiros, Oslei Paes de Almeida, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Helder Antonio Rebelo Pontes, Manoela Domingues Martins, Vinícius Coelho Carrard, Alan Roger Santos-Silva
OBJECTIVES: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. STUDY DESIGN: A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin-stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures...
January 9, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28224196/calcium-and-oxidative-stress-mediate-perillaldehyde-induced-apoptosis-in-candida-albicans
#4
Hui Tian, Su Qu, Yanzhen Wang, Zhaoqun Lu, Man Zhang, Yeyun Gan, Peng Zhang, Jun Tian
New anti-Candida albicans drugs are needed due to the emergence of resistant cases in recent years. Perillaldehyde (PAE) is a natural monoterpenoid compound derived from Perilla frutescens. The minimum inhibitory concentration of PAE against C. albicans was 0.4 μL/mL. We aimed to elucidate the antifungal mode of action of PAE against C. albicans. The antifungal activity of PAE against C. albicans was found to correlate with an elevation in intracellular Ca(2+) and accumulation of ROS. Several downstream apoptosis events such as the disruption of mitochondrial membrane potential, phosphatidylserine externalization, cytochrome c release, and metacaspase activation were observed in PAE-treated cells...
February 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28216975/negative-oncologic-impact-of-poor-postoperative-pain-control-in-left-sided-pancreatic-cancer
#5
Eun-Ki Min, Jae Uk Chong, Ho Kyoung Hwang, Sang Joon Pae, Chang Moo Kang, Woo Jung Lee
AIM: To investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma (PDAC). METHODS: From January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale (NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28216654/performance-kinetic-and-biodegradation-pathway-evaluation-of-anaerobic-fixed-film-fixed-bed-reactor-in-removing-phthalic-acid-esters-from-wastewater
#6
Ehsan Ahmadi, Samira Yousefzadeh, Mohsen Ansari, Hamid Reza Ghaffari, Ali Azari, Mohammad Miri, Alireza Mesdaghinia, Ramin Nabizadeh, Babak Kakavandi, Peyman Ahmadi, Mojtaba Yegane Badi, Mitra Gholami, Kiomars Sharafi, Mostafa Karimaei, Mahboobeh Ghoochani, Masoud Binesh Brahmand, Seyed Mohsen Mohseni, Maryam Sarkhosh, Soheila Rezaei, Hosseinali Asgharnia, Emad Dehghanifard, Behdad Jafari, Alireza Mortezapour, Vahid Kazemi Moghaddam, Mohammad Molla Mahmoudi, Nader Taghipour
Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine disrupting effects on human health. Industrial wastewater has been reported as an important environment with high concentrations of PAEs. In the present study, four short-chain PAEs including diallyl phthalate (DAP), diethyl phthalate (DEP), dimethyl phthalate (DMP), and phthalic acid (PA) were selected as a substrate for anaerobic fixed film fixed bed reactor (AnFFFBR)...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215511/popliteal-artery-entrapment-syndrome-in-children-experience-with-four-cases-of-acute-ischaemia-and-review-of-the-literature
#7
REVIEW
N Settembre, Z Bouziane, M A Bartoli, V Nabokov, M Venermo, P Feugier, S Malikov
OBJECTIVE: Popliteal artery entrapment syndrome (PAES) is an uncommon anatomical anomaly, frequently described in adults. The most common symptom is claudication. Acute limb ischaemia (ALI) in children is rare, but it may evolve and lead to limb loss or lifelong complications. Clinical and surgical experience of PAES in children is reported. Data from the literature are analysed in order to assess the severity of this disease and to identify the factors characterising the diagnosis and the outcome of treatment in paediatric patients...
February 16, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28210574/rosai-dorfman-disease-affecting-the-maxilla
#8
Thaís Gimenez Miniello, Juliane Piragine Araujo, Norberto Nobuo Sugaya, Fernando Melhem Elias, Oslei Paes de Almeida, Fabio Abreu Alves
Rosai-Dorfman disease (RDD), formerly called sinus histiocytosis with massive lymphadenopathy, is a non-neoplastic proliferative histiocytic disorder with behavior ranging from highly aggressive to spontaneous remission. Although the lymph nodes are more commonly involved, any organ can be affected. This study aimed to describe the features and the follow-up of a case of extranodal RDD. Our patient was a 39-year-old woman who was referred with an 11-month history of pain in the right maxilla. On clinical examination, some upper right teeth presented full mobility with normal appearance of the surrounding gingiva...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28210458/osseous-oral-hyaline-ring-granuloma-mimicking-a-mandible-tumor-in-a-child-with-congenital-agenesis-of-the-corpus-callosum
#9
Rodrigo Neves-Silva, Camilla-Borges Ferreira-Gomes, Natalia Palmier, Marcelo Brum-Corrêa, Oslei Paes-Almeida, Marcio Ajudarte-Lopes, Pablo Agustin-Vargas, Alan-Roger Santos-Silva
BACKGROUND: Hyaline ring granuloma (HRG) of the oral cavity is an uncommon disorder considered to be a foreign-body reaction resulting from implantation of food vegetable particles. Microscopically, it is characterized by the presence of structures of hyaline rings in an inflamed fibrous tissue background, which contains multinucleated giant cells. MATERIAL AND METHODS: We present the case of a 4-year-old boy diagnosed with a mandible osseous HRG, which showed clinical and tomographic aspects suggestive of an aggressive bone tumor...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28207919/tardive-dyskinesia-21st-century-may-bring-new-treatments-to-a-forgotten-disorder
#10
Gopalkumar Rakesh, Andrew Muzyk, Steven T Szabo, Sanjay Gupta, Chi-Un Pae, Prakash Masand
BACKGROUND: Tardive dyskinesia (TD) is a condition that was first described nearly 60 years ago. Despite the tremendous amount of research on pathophysiology and numerous follow-up studies to understand the course and prognosis of TD, effective treatment of the condition continued to elude us until recently. METHODS: We review and summarize clinical literature on TD, as well as provide an update on new treatments available. RESULTS: The emergence of tetrabenazine as a treatment modality decreased suffering and improved quality of life for patients...
February 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207864/characterisation-and-genome-sequence-of-the-lytic-acinetobacter-baumannii-bacteriophage-vb_abas_loki
#11
Dann Turner, Matthew E Wand, Yves Briers, Rob Lavigne, J Mark Sutton, Darren M Reynolds
Acinetobacter baumannii has emerged as an important nosocomial pathogen in healthcare and community settings. While over 100 of Acinetobacter phages have been described in the literature, relatively few have been sequenced. This work describes the characterisation and genome annotation of a new lytic Acinetobacter siphovirus, vB_AbaS_Loki, isolated from activated sewage sludge. Sequencing revealed that Loki encapsulates a 41,308 bp genome, encoding 51 predicted open reading frames. Loki is most closely related to Acinetobacter phage IME_AB3 and more distantly related to Burkholderia phage KL1, Paracoccus phage vB_PmaS_IMEP1 and Pseudomonas phages vB_Pae_Kakheti25, vB_PaeS_SCH_Ab26 and PA73...
2017: PloS One
https://www.readbyqxmd.com/read/28203320/interplay-between-oxidative-stress-and-metabolism-in-signalling-and-disease-2016
#12
EDITORIAL
Eric E Kelley, Antonio Marcus de Andrade Paes, Hariom Yadav, Celia Quijano, Adriana Cassina, Andrés Trostchansky
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28198790/in-reply-completed-weeks-of-gestation-and-risk-of-respiratory-syncytial-virus-in-late-preterm-infants
#13
Margaret Sheridan-Pereira, Bosco Paes
No abstract text is available yet for this article.
February 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28194935/a-potential-pet-radiotracer-for-the-5-ht2c-receptor-synthesis-and-in-vivo-evaluation-of-4-3-18-f-fluorophenethoxy-pyrimidine
#14
Juhyeon Kim, Byung Seok Moon, Byung Chul Lee, Ho-Young Lee, Hak Joong Kim, Hyunah Choo, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT receptor widely distributed throughout the central nerve system. As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine and -aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety. Up to date, three kinds of 5-HT2C PET radiotracers such as [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2), [18F]fluorophenylcyclopropane (3) have been developed, but they may not be suitable for in vivo 5-HT2C imaging study due to their modest specific binding...
February 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28194505/adenomatous-dominant-benign-prostatic-hyperplasia-adbph-as-a-predictor-for-clinical-success-following-prostate-artery-embolization-an-age-matched-case-control-study
#15
M W Little, P Boardman, A C Macdonald, N Taylor, R Macpherson, J Crew, C R Tapping
PURPOSE: To investigate the clinical impact of performing prostate artery embolization (PAE) on patients with adenomatous-dominant benign prostatic hyperplasia (AdBPH). MATERIALS AND METHODS: Twelve patients from the ongoing proSTatic aRtery EmbolizAtion for the treatMent of benign prostatic hyperplasia (STREAM) trial were identified as having AdBPH; defined as two or more adenomas within the central gland of ≥1 cm diameter on multi-parametric MRI (MP-MRI). These patients were age-matched with patients from the STREAM cohort, without AdBPH...
February 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28192433/review-of-21-cases-of-mycetoma-from-1991-to-2014-in-rio-de-janeiro-brazil
#16
Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80...
February 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28191037/understanding-the-structural-and-chemical-changes-of-plant-biomass-following-steam-explosion-pretreatment
#17
Thomas Auxenfans, David Crônier, Brigitte Chabbert, Gabriel Paës
BACKGROUND: Biorefining of lignocellulosic biomass has become one of the most valuable alternatives for the production of multi-products such as biofuels. Pretreatment is a prerequisite to increase the enzymatic conversion of the recalcitrant lignocellulose. However, there is still considerable debate regarding the key features of biomass impacting the cellulase accessibility. In this study, we evaluate the structural and chemical features of three different representative biomasses (Miscanthus × giganteus, poplar and wheat straw), before and after steam explosion pretreatment at increasing severities, by monitoring chemical analysis, SEM, FTIR and 2D NMR...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28187949/long-term-alterations-to-dna-methylation-as-a-biomarker-of-prenatal-alcohol-exposure-from-mouse-models-to-human-children-with-fetal-alcohol-spectrum-disorders
#18
REVIEW
Benjamin I Laufer, Eric J Chater-Diehl, Joachim Kapalanga, Shiva M Singh
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA cytosine methylation in the developing brain. The resulting genome-wide methylation changes are enriched in genes with neurodevelopmental functions. The profile of differential methylation is dynamic and present in some form for life. The methylation changes are transmitted across subsequent mitotic divisions, where they are maintained and further modified over time. More recent follow up has identified a profile of the differential methylation in the buccal swabs of young children born with FASD...
November 22, 2016: Alcohol
https://www.readbyqxmd.com/read/28187467/protective-effects-of-ellagic-acid-on-cardiovascular-injuries-caused-by-hypertension-in-rats
#19
Juliana Bahia Reis Jordão, Hellen Karine Paes Porto, Flávio Marques Lopes, Aline Carvalho Batista, Matheus Lavorenti Rocha
Ellagic acid is described as having antioxidant and antiproliferative properties. Hence, it was hypothesized that ellagic acid could improve cardiovascular damage caused by hypertension. In this work, hypertension was induced in rats with Nω-Nitro-L-arginine methyl ester hydrochloride (60 mg/kg/day in drinking water) for 6 weeks. Ellagic acid was coadministered (10 or 30 mg/kg/day by gavage) between the second and sixth week. Blood pressure was recorded every week by tail-cuff plethysmography. After 6 weeks, the rats were sacrificed, the hearts and kidneys were weighed, and blood was collected...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28186713/fetal-alcohol-research-caring-for-patients-with-prenatal-alcohol-exposure-a-needs-assessment
#20
Vincent C Smith, Phillip Matthias, Yasmin N Senturias, Renee M Turchi, Janet F Williams
BACKGROUND: Prenatal alcohol exposure (PAE) is the United States' most common preventable cause of birth defects and intellectual and developmental disabilities collectively referred to as Fetal Alcohol Spectrum Disorders (FASD). OBJECTIVES: This study was designed to identify gaps in pediatric providers' knowledge and practices regarding FASD patient identification, diagnosis, management and referral, and to inform needs-based FASD resource development. METHODS: Pediatric providers (pediatricians, trainees, nurse practitioners) were exposed to survey links embedded in newsletters electronically distributed to the membership of two national professional societies...
January 27, 2017: Journal of Population Therapeutics and Clinical Pharmacology
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