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https://www.readbyqxmd.com/read/28432089/preparing-future-doctors-for-palliative-care-views-of-course-organisers
#1
Steven Walker, Jane Gibbins, Paul Paes, Stephen Barclay, Astrid Adams, Madawa Chandratilake, Faye Gishen, Philip Lodge, Bee Wee
BACKGROUND: Effective training at medical school is essential to prepare new doctors to safely manage patients with palliative care (PC) and end of life care (EOLC) needs. The contribution of undergraduate PC course organisers is central but their collective views regarding role are unknown. OBJECTIVE: To survey attitudes of PC course organisers regarding their course, organisation, the adequacy of training provided and level of personal satisfaction. METHODS: An anonymised, multifactorial, web-based questionnaire was devised, tested, modified and then sent to lead PC course organisers at all UK medical schools...
April 21, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28431792/changes-to-histone-modifications-following-prenatal-alcohol-exposure-an-emerging-picture
#2
REVIEW
Eric J Chater-Diehl, Benjamin I Laufer, Shiva M Singh
Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol Spectrum Disorders (FASD). Extensive research into the role of DNA methylation and miRNAs in animal models has illuminated the complex role of these mechanisms in FASD. In contrast, histone modifications have not been as well researched, due in part to being less stable than DNA methylation and less well-characterized in disease. It is now apparent that even changes in transient marks can have profound effects if they alter developmental trajectories...
February 4, 2017: Alcohol
https://www.readbyqxmd.com/read/28430670/comparison-between-long-acting-injectable-aripiprazole-versus-paliperidone-palmitate-in-the-treatment-of-schizophrenia-systematic-review-and-indirect-treatment-comparison
#3
Chi-Un Pae, Sheng-Min Wang, Changsu Han, Won-Myong Bahk, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Alessandro Serretti, Robin Emsley
We investigated the relative efficacy and tolerability of aripiprazole once monthly (AOM) versus paliperidone palmitate (PP) for treating schizophrenia. Extensive databases searches on short-term, placebo-controlled, randomized studies of AOM and PP were performed. Indirect treatment comparisons were performed between the two long-acting injectable antipsychotics (LAIAs). The primary efficacy endpoint was the mean change in the Positive and Negative Syndrome Scale total score from baseline between each LAIA and placebo...
April 20, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28429193/effect-of-non-coherent-infrared-light-led-%C3%AE-945%C3%A2-%C3%A2-%C3%A2-20%C3%A2-nm-on-bone-repair-in-diabetic-rats-morphometric-and-spectral-analyses
#4
Alexandre Greca Diamantino, Renata Amadei Nicolau, Davidson Ribeiro Costa, Alessandra Paes de Barros Almeida, Danila Xênia de Miranda Mato, Marco Antonio de Oliveira, Ana Maria do Espírito Santo
Phototherapy using coherent light (lasers) and non-coherent light (light-emitting diodes (LEDs)) has been investigated for the purpose of biomodulation in biological tissues. Several effects can be expected, including pain moderation, biostimulation of cellular tropism, anti-inflammatory effects, regular circulatory stimulation, and tissue repair. The aim of this study was to evaluate the effect of LED (λ945 ± 20 nm, 48 mW) therapy on the regeneration process in femoral lesions of rats (Wistar). Seven irradiation sessions were held, with a 48-h interval between sessions...
April 20, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28422344/use-of-blood-pool-agents-with-steady-state-mri-to-assess-the-vascular-system
#5
Avnesh S Thakor, John Chung, Premal Patel, Anthony Chan, Amdad Ahmed, Graeme McNeil, David M Liu, Bruce Forster, Darren Klass
Over the past two decades there have been significant advances in the use of magnetic resonance imaging (MRI) to assess the vascular system. New imaging sequences and improvements in magnet design have enabled the creation of higher spatial resolution images. MRI is now a viable alternative imaging modality when compared to both invasive angiography and computed tomographic angiography. The use of blood pool agents has further facilitated the use of MR angiography (MRA); their high molecular weight allows for lower doses of contrast medium administration while their prolonged presence in the blood stream allows for repeated high-quality volumetric imaging of both the arterial and venous circulation...
April 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28420900/intracranial-pressure-monitoring-for-pediatric-acute-encephalopathy
#6
Nobuyuki Nosaka, Kohei Tsukahara, Emily Knaup, Toshihiko Yabuuchi, Tomonobu Kikkawa, Yosuke Fujii, Masato Yashiro, Takao Yasuhara, Ayumi Okada, Toyomu Ugawa, Atsunori Nakao, Hirokazu Tsukahara, Isao Date
Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28417368/bioinspired-assemblies-of-plant-cell-walls-for-measuring-protein-carbohydrate-interactions-by-frap
#7
Gabriel Paës
The interactions of proteins involved in plant cell wall hydrolysis, such as enzymes and CBMs, significantly determine their role and efficiency. In order to go beyond the characterization of interactions with simple ligands, bioinspired assemblies combined with the measurement of diffusion and interaction by FRAP offer a relevant alternative for highlighting the importance of different parameters related to the protein affinity and to the assembly.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28414217/selection-of-group-specific-pae-binding-dna-aptamers-via-rational-designed-target-immobilization-and-applications-for-ultrasensitive-and-highly-selective-detection-of-paes
#8
Yu Han, Donglin Diao, Zhangwei Lu, Xiaoning Li, Qian Guo, Yumeng Huo, Qing Xu, Youshan Li, Sheng-Li Cao, Jianchun Wang, Yuan Wang, Jiaxing Zhao, Zhongfeng Li, Miao He, Zhaofeng Luo, Xinhui Lou
Phthalic acid esters(PAEs) are ubiquitous in the environment and some of them are recognized as endocrine disruptors that cause concerns on ecosystem functioning and public health. Due to the diversity of PAEs in the environment, there is a vital need to detect the total concentration of PAEs in a timely and low-cost way. To fulfill this requirement, it is highly desired to obtain group-specific PAE binders that are specific to the basic PAE skeleton. In this study, for the first time we have identified the group-specific PAE-binding aptamers via rational designed target immobilization...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28412979/physical-exercise-for-late-life-depression-effects-on-cognition-and-disability
#9
Francesca Neviani, Martino Belvederi Murri, Chiara Mussi, Federico Triolo, Giulio Toni, Elisabetta Simoncini, Ferdinando Tripi, Marco Menchetti, Silvia Ferrari, Graziano Ceresini, Alessandro Cremonini, Marco Bertolotti, Giovanni Neri, Salvatore Squatrito, Mario Amore, Stamatula Zanetidou, Mirco Neri
BACKGROUND: Late-life depression is often associated with cognitive impairments and disability, which may persist even after adequate antidepressant drug treatment. Physical exercise is increasingly recognized as an effective antidepressant agent, and may exert positive effects on these features too. However, few studies examined this issue, especially by comparing different types of exercises. METHODS: We performed secondary analyses on data from the Safety and Efficacy of Exercise for Depression in Seniors study, a trial comparing the antidepressant effectiveness of sertraline (S), sertraline plus thrice-weekly non-progressive exercise (S+NPE), and sertraline plus thrice-weekly progressive aerobic exercise (S+PAE)...
April 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28412076/original-article-varicella-vaccination-elicits-a-humoral-and-cellular-response-in-children-with-rheumatic-diseases-using-immune-suppressive-treatment
#10
Noortje Groot, Gecilmara Pileggi, Cleonice B Sandoval, Ingrid Grein, Guy Berbers, Virginia Paes Leme Ferriani, Nico Wulffraat, Sytze de Roock
OBJECTIVE: To assess humoral and cellular responses to live-attenuated varicella zoster virus (VZV) vaccination of patients with juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM) or juvenile scleroderma (JScle) compared to those of healthy controls (HC). METHODS: Before, 4-6weeks and one year after VZV vaccination, blood samples of patients and HC were collected. VZV-specific antibody concentrations were measured by ELISA and multiplex immune-assay...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28407986/intravenous-bisphosphonate-therapy-does-not-thicken-cementum-or-change-periodontal-ligaments-of-cancer-patients
#11
Mariana de Pauli Paglioni, Wagner Gomes Silva, Juliana Pereira, César Augusto Migliorati, Marcio Ajudarte Lopes, Oslei Paes de Almeida, Mario Fernando Goes, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Alan Roger Santos-Silva
OBJECTIVE: To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. STUDY DESIGN: Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy...
May 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28407549/estrogenicity-assessment-of-membrane-concentrates-from-landfill-leachate-treated-by-the-uv-fenton-process-using-a-human-breast-carcinoma-cell-line
#12
Changcheng Hou, Gang Lu, Ling Zhao, Pinghe Yin, Lingfei Zhu
Membrane concentrates (MCs) are generated when membranes are used to concentrate landfill leachate. It contains high concentrations of inorganic and organic environmental pollutants, which are highly toxic and carcinogenic. In this paper, the proliferation effect (PE) from MC before and after treatment with the UV-Fenton process was assessed using the human breast carcinoma cell line MCF-7. The highest value of 116% was found at 5% (v/v) concentration after a 10 min reaction. Phthalic acid esters (PAEs) play an important role in the MC estrogenicity...
April 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28403312/nursing-throughout-war-times-political-propaganda-and-professional-valorization-1942-1945
#13
Thais da Silva Kneodler, Graciele Oroski Paes, Fernando Rocha Porto, Pedro Ruiz Barbosa Nassar, Alexandre Barbosa de Oliveira
OBJECTIVE: to discuss the symbolic effects of the publication on written press of institutional rites related to the courses promoted by the Brazilian Federal District's Schools of Nursing during the Second World War. METHOD: exploratory and documentary study, whose sources were treated by historical method. RESULTS: one noticed, in the news reports analyzed, that the Brazilian Estado Novo has used nurses images to divulge within the society the woman's acting altruistic model in service to the country, through the systematic diffusion by the press of her honorable acting during the war, what assured the amplification of the visibility and acknowledgment of the Nursing profession in that context...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403044/comparing-first-and-second-year-palivizumab-prophylaxis-in-patients-with-hemodynamically-significant-congenital-heart-disease-in-the-caress-database-2005-2015
#14
MULTICENTER STUDY
Abby Li, Daniel Y Wang, Krista L Lanctôt, Ian Mitchell, Bosco A Paes
BACKGROUND: Respiratory syncytial virus hospitalization (RSVH) rates in children <2 years of age with hemodynamically significant congenital heart disease (HSCHD) are 2- to 4-fold higher compared with healthy term infants. Pediatric recommendations differ as to whether palivizumab is beneficial beyond 1 year of age. The objective of this study was to determine whether differences exist in respiratory-related illness hospitalization (RIH) and RSVH in HSCHD infants receiving palivizumab during the first year versus second year of life in the Canadian Registry of Palivizumab...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28402495/analysis-of-aneuploid-lines-of-bread-wheat-to-map-chromosomal-locations-of-genes-controlling-root-hair-length
#15
Miao Liu, Tina Rathjen, Kumara Weligama, Kerrie Forrest, Matthew Hayden, Emmanuel Delhaize
Background and Aims: Long root hairs enable the efficient uptake of poorly mobile nutrients such as phosphorus. Mapping the chromosomal locations of genes that control root hair length can help exploit the natural variation within crops to develop improved cultivars. Genetic stocks of the wheat cultivar 'Chinese Spring' were used to map genes that control root hair length. Methods: Aneuploid stocks of 'Chinese Spring' were screened using a rapid method based on rhizosheath size and then selected lines were assayed for root hair length to identify chromosomes harbouring genes controlling root hair length...
April 11, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28401870/response-of-narrow-qrs-tachycardia-to-premature-atrial-extra-what-is-the-mechanism
#16
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Bharatraj Banavalikar, Sreevilasam Pushpangadhan Abhilash, Anees Thajudeen, Ajitkumar Valaparambil
A 60-year-old woman was referred for radiofrequency catheter ablation of narrow QRS tachycardia that was terminated with intravenous adenosine. Twelve-lead ECG showed no baseline preexcitation. Echocardiogram was essentially normal. The electrophysiological study showed a normal AH interval of 114 ms and HV interval of 48 ms during sinus rhythm. Anterograde study demonstrated no dual AV nodal physiology. Atrial pacing protocols easily and reproducibly induced narrow QRS tachycardia (Fig. 1A & 1B). Premature atrial extra (PAE) stimuli were delivered during the tachycardia (Fig...
November 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28401267/paeonol-protects-against-tnf-%C3%AE-induced-proliferation-and-cytokine-release-of-rheumatoid-arthritis-fibroblast-like-synoviocytes-by-upregulating-foxo3-through-inhibition-of-mir-155-expression
#17
Ning Liu, Xue Feng, Wenbo Wang, Xingkai Zhao, Xia Li
BACKGROUND: Fibroblast-like synoviocytes (FLS) play an essential role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. Paeonol (Pae) is a phenolic compound found in many traditional Chinese medicine remedies. However, the effects of Pae on TNF-α-stimulated FLS and the underlying molecular mechanism are unknown. In this study, we aimed to investigate the anti-proliferative and anti-inflammatory effect of Pae against activated FLS. MATERIALS AND METHODS: Rheumatoid arthritis FLS (RA-FLS) were pre-treated with different doses (25, 50, and 100 µM) of Pae or miR-155 inhibitor for 30 min or transfected with miR-155 mimic, and then treated with 50 ng/mL of tumor necrosis factor alpha (TNF-α) for 1 h...
April 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28401132/comparing-diagnostic-classification-of-neurobehavioral-disorder-associated-with-prenatal-alcohol-exposure-with-the-canadian-fetal-alcohol-spectrum-disorder-guidelines-a-cohort-study
#18
James L Sanders, Rebecca E Hudson Breen, Nicole Netelenbos
BACKGROUND: Diagnostic criteria have recently been introduced in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), for neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE). The purpose of this study is to assess the classification of this condition using the Canadian fetal alcohol spectrum disorder (FASD) multidisciplinary diagnostic guidelines as the standard of comparison. First, classification of ND-PAE was compared with Canadian FASD diagnoses of fetal alcohol syndrome (FAS), partial FAS and alcohol-related neurodevelopmental disorder...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28397969/aim2-inflammasome-is-associated-to-disease-severity-in-tegumentary-leishmaniasis-caused-by-leishmania-v-braziliensis
#19
Regina Barbosa Moreira, Claude Pirmez, Manoel Paes De Oliveira-Neto, Luana De Souza Aguiar, Antonio José Da Silva Gonçalves, Luiza Oliveira Ramos Pereira, Lais Abreu, Márcia Pereira De Oliveira
The inflammasome is a multiprotein signaling platform involved in the pathogenesis of various inflammatory skin diseases. Herein, we investigated gene and protein expression of the inflammasome molecules AIM2 and NLRP3 in active lesions from patients with L. (V.) braziliensis-associated tegumentary leishmaniasis (TL) and correlated these findings with the clinical presentations and responses to therapy. Real-time PCR assays showed a significantly higher AIM2 gene expression in mucosal leishmaniasis (ML) compared with that in cutanoeus leishmaniasis (CL)...
April 11, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28396191/prostate-artery-embolization-via-transradial-or-transulnar-versus-transfemoral-arterial-access-technical%C3%A2-results
#20
Shivank Bhatia, Sardis H Harward, Vishal K Sinha, Govindarajan Narayanan
PURPOSE: To compare safety and feasibility of prostate artery embolization (PAE) via transradial/transulnar access (TR/UA) and transfemoral access (TFA). MATERIALS AND METHODS: A retrospective analysis was conducted for 3 cohorts: the first 32 consecutive PAE procedures performed via TFA (initial TFA, January 2014 to August 2015), the following 32 procedures performed via TFA (advanced TFA, August 2015 to February 2016), and the first 32 procedures performed via TR/UA (February 2016 to July 2016)...
April 7, 2017: Journal of Vascular and Interventional Radiology: JVIR
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