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https://www.readbyqxmd.com/read/28333028/embryo-stage-of-development-is-not-decisive-for-reproductive-outcomes-in-frozen-thawed-embryo-transfer-cycles
#1
Bruno R de Carvalho, Marina W Paes Barbosa, Helena Bonesi, David B Gomes, Íris O Cabral, Antônio C Paes Barbosa, Adelino A Silva, José R Iglesias, Hitomi M Nakagawa
OBJECTIVE: To evaluate if the outcomes of IVF/ICSI in frozen-thawed embryo transfer and fresh embryo transfer cycles differ in relation to cleavage and blastocyst stages. METHODS: Retrospective cohort study to compare IVF/ICSI outcomes between fresh embryo transfer and frozen-thawed embryo transfer cycles, according to the stage of embryo development. Analysis was carried out on 443 consecutive embryo transfer cycles performed between January 1st and December 31st, 2014...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28330828/early-postnatal-iron-deficiency-impacts-plasticity-in-the-dorsal-and-ventral-hippocampus-in-piglets
#2
Ellis Nelissen, Jochen De Vry, Alexandra Antonides, Dean Paes, Melissa Schepers, Franz Josef van der Staay, Jos Prickaerts, Tim Vanmierlo
In this study, we investigated whether alterations in plasticity markers such as brain-derived neurotrophic factor (BDNF), p75 neurotrophin receptor (p75(NTR)) and tyrosine receptor kinase B (TrkB) are underlying iron deficiency (ID)-induced cognitive impairments in iron depleted piglets. Newborn piglets were either fed an iron-depleted diet (21mg Fe/kg) or an iron-sufficient diet (88mg Fe/kg) for four weeks. Subsequently, eight weeks after iron repletion (190-240mg Fe/kg) we found a significant decrease in mature BDNF (14kDa) and proBDNF (18kDa and 24kDa) protein levels in the ventral hippocampus, whereas we found increases in the dorsal hippocampus...
March 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28327793/insights-into-cytochrome-bc1-complex-binding-mode-of-antimalarial-2-hydroxy-1-4-naphthoquinones-through-molecular-modelling
#3
Ana Carolina Rennó Sodero, Bárbara Abrahim-Vieira, Pedro Henrique Monteiro Torres, Pedro Geraldo Pascutti, Célia Rs Garcia, Vitor Francisco Ferreira, David Rodrigues da Rocha, Sabrina Baptista Ferreira, Floriano Paes Silva
BACKGROUND: Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES: The aim of this work was to perform molecular modelling studies of 2-hydroxy-1,4-naphthoquinones analogues of atovaquone on the Qo site of P. falciparum cytochrome bc1 complex (Pfbc1) to suggest structural modifications that could improve their antimalarial activity...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28326123/relationship-between-depression-and-laryngopharyngeal-reflux
#4
Young-Hoon Joo, Youn-Su Song, Chi-Un Pae
This study investigated the relationship between depression, somatization, anxiety, personality, and laryngopharyngeal reflux (LPR). We prospectively analyzed 231 patients with symptoms with LPR using the laryngopharyngeal reflux symptom index and the reflux finding score. Seventy nine (34.2%) patients were diagnosed with LPR. A significant correlation was detected between the presence of LPR and total scores on the Patient Health Questionnaire-9 (5.6±5.3 vs. 4.0±4.6, p=0.017) and the 7-item Generalized Anxiety Disorder Scale (4...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28325095/concomitant-use-of-fsh-and-low-dose-recombinant-hcg-during-the-late-follicular-phase-versus-conventional-controlled-ovarian-stimulation-for-intracytoplasmic-sperm-injection-cycles
#5
Carla Andrade Rebello Iaconelli, Amanda Souza Setti, Daniela Paes Almeida Ferreira Braga, Luiz Guilherme Louzada Maldonado, Assumpto Iaconelli, Edson Borges, Tsutomu Aoki
The objective of this study was to investigate the effects of low-dose hCG supplementation on ICSI outcomes and controlled ovarian stimulation (COS) cost. Three hundred and thirty patients undergoing ICSI were split into groups according to the COS protocol: (i) control group (n = 178), including patients undergoing conventional COS treatment; and (ii) low-dose hCG group (n = 152), including patients undergoing COS with low-dose hCG supplementation. Lower mean total doses of FSH administered and higher mean oestradiol level and mature oocyte rates were observed in the low-dose hCG group...
March 22, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28324840/biosorption-of-diethyl-phthalate-ester-by-living-and-nonliving-burkholderia-cepacia-and-the-role-of-its-cell-surface-components
#6
Si Luo, Langlang Li, Anwei Chen, Qingru Zeng, Hao Xia, Ji-Dong Gu
In this study, the dibutyl phthalate (DBP) binding properties of a DBP-tolerant bacterium (B. cepacia) were characterized in terms of adsorption kinetics and isotherm. Living and nonliving cells both exhibited rapid removal of DBP, achieving more than 80% of maximum sorption within 30 min of contact and reached the equilibrium after 3 h. The adsorption isotherms were well fitted with the Sips model and the nonliving cells have greater biosorption capacity and affinity for DBP than the living cells. Furthermore, the absence of an active mechanism dependent on metabolism implied that the DBP bioaccumulation by living cells was mainly attribute to passive surface binding...
March 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28323403/discovery-of-potent-antiallodynic-agents-for-neuropathic-pain-targeting-p2x3-receptors
#7
Young-Hwan Jung, Yong-Chul Kim, Yeo Ok Kim, Hai Lin, Joong-Heui Cho, Jin-Hee Park, So-Deok Lee, Jinsu Bae, Koon Mook Kang, Yoon Gyoon Kim, Ae Nim Pae, Hyojin Ko, Chul-Seung Park, Myung Ha Yoon
Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system. In this study, 5-hydroxy pyridine derivatives were designed, synthesized, and evaluated for their in vitro biological activities by two-electrode voltage clamp assay at hP2X3 receptors. Among the novel hP2X3 receptor antagonists, intrathecal treatment of compound 29 showed parallel efficacy with pregabalin (calcium channel modulator) and higher efficacy than AF353 (P2X3 receptor antagonist) in the evaluation of its antiallodynic effects in spinal nerve ligation rats...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28320726/glucantime%C3%A2-causes-oxidative-stress-derived-dna-damage-in-balb-c-mice-infected-by-leishmania-leishmania-infantum
#8
Vanessa Ribeiro Moreira, Luís Cláudio Lima de Jesus, Rossy-Eric Pereira Soares, Luis Douglas Miranda Silva, Bruno Araújo Serra Pinto, Maria Norma Melo, Antonio Marcus de Andrade Paes, Silma Regina Ferreira Pereira
Leishmaniasis is a neglected tropical disease caused by over 20 species of the protozoan parasite Leishmania Regarding treatment, Glucantime® is the first-choice drug recommended by the World Health Organization for the treatment of all types of leishmaniasis. However, the mechanisms of action and toxicity of pentavalent antimonials, including genotoxic effetcs, remain unclear. Therefore, the mechanism by which Glucantime® causes DNA damage was investigated in BALB/c mice infected by Leishmania (Leishmania) infantum and treated with Glucantime® (20 mg/kg for 20 days)...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320722/in-vitro-and-in-vivo-antibacterial-activities-of-patchouli-alcohol-a-natural-occurring-tricyclic-sesquiterpene-against-helicobacter-pylori-infection
#9
Y F Xu, D W Lian, Y Q Chen, Y F Cai, Y F Zheng, P L Fan, W K Ren, L J Fu, Y C Li, J H Xie, H Y Cao, B Tan, Z R Su, P Huang
This study further evaluated the in vitro and in vivo anti-Helicobacter pylori activity and potential underlying mechanism of patchouli alcohol (PA), a tricyclic sesquiterpene. In in vitro assay, the capacities of PA to inhibit and kill H. pylori were tested on three standard strains at different pH values and 12 clinical isolates. The effects of PA on H. pylori adhesion (and its alpA, alpB and babA genes), motility (and its flaA and flaB genes), ultrastructure and flagellation were investigated. Moreover, the H...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28319143/toxicity-effects-of-di-2-ethylhexyl-phthalate-to-eisenia-fetida-at-enzyme-cellular-and-genetic-levels
#10
Tingting Ma, Wei Zhou, Li'ke Chen, Longhua Wu, Peter Christie, Haibo Zhang, Yongming Luo
Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied in the body of the earthworm by means of soil cultivation tests 7, 14, 21 and 28 days after exposure. The results indicated that, in general, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, metallothionein (MT) content, the expression of heat shock protein 70 (HSP 70) and all the tested geno-toxicity parameters are promoted as time elapses and with increasing concentration of DEHP...
2017: PloS One
https://www.readbyqxmd.com/read/28316976/mutagenic-and-cytotoxicity-lqb-123-profile-safety-and-tripanocidal-effect-of-a-phenyl-t-butylnitrone-derivative
#11
Mauricio Peixoto Cupello, Francis Monique Saraiva, Pedro Ippolito, Andréia da Silva Fernandes, Rubem Figueiredo Sadoko Menna-Barreto, Debora de Sousa Dos Santos Costa, Jessica Isis Oliveira Paula, Paulo Roberto Ribeiro Costa, Natália Pereira Nogueira, Israel Felzenswalb, Ayres Guimarães Dias, Marcia Cristina Paes
The therapeutic options for Chagas disease are limited and its treatment presents a number of drawbacks including toxicity, drug resistance, and insufficient effectiveness against the chronic stage of the disease. Therefore, new therapeutical options are mandatory. In the present work, we evaluated the effect of a phenyl-tert-butylnitrone (PBN) derivate, LQB 123, against Trypanosoma cruzi forms. LQB 123 presented a trypanocidal effect against bloodstream trypomastigotes (IC50 = 259.4 ± 6.1 μM) and intracellular amastigotes infecting peritoneal macrophages (IC50 = 188...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28315958/brain-tumor-location-influences-the-onset-of-acute-psychiatric-adverse-events-of-levetiracetam-therapy-an-observational-study
#12
Vincenzo Belcastro, Laura Rosa Pisani, Silvio Bellocchi, Paolo Casiraghi, Gaetano Gorgone, Marco Mula, Francesco Pisani
To explore possible correlations among brain lesion location, development of psychiatric symptoms and the use of antiepileptic drugs (AEDs) in a population of patients with brain tumor and epilepsy. The medical records of 283 patients with various types of brain tumor (161 M/122 F, mean age 64.9 years) were analysed retrospectively. Patients with grade III and IV glioma, previous history of epileptic seizures and/or psychiatric disorders were excluded. Psychiatric symptoms occurring after initiation of AED therapy were considered as treatment emergent psychiatric adverse events (TE-PAEs) if they fulfilled the following conditions: (1) onset within 4 weeks after the beginning of AED therapy; (2) disappearance on drug discontinuation; (3) absence of any other identified possible concurrent cause...
March 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28315117/the-evolution-of-pollution-profile-and-health-risk-assessment-for-three-groups-svocs-pollutants-along-with-beijiang-river-china
#13
Jiao Tang, Taicheng An, Jukun Xiong, Guiying Li
Three important groups of semi-volatile organic compounds (SVOCs), polycyclic aromatic hydrocarbons (PAHs), organic chlorinated pesticides (OCPs) and phthalate esters (PAEs), were produced by various human activities and entered the water body. In this study, the pollution profiles of three species including 16 PAHs, 20 OCPs and 15 PAEs in water along the Beijiang River, China were investigated. The concentrations of Σ16PAHs in the dissolved and particulate phases were obtained as 69-1.5 × 10(2) ng L(-1) and 2...
March 17, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28314431/fast-analysis-of-phthalates-in-freeze-dried-baby-foods-by-ultrasound-vortex-assisted-liquid-liquid-microextraction-coupled-with-gas-chromatography-ion-trap-mass-spectrometry
#14
Mario Vincenzo Russo, Pasquale Avino, Ivan Notardonato
This paper is focused on the determination of phthalates (PAEs), compounds "plausibly" endocrine disruptors, in baby food products by means of a method based on ultrasound-vortex-assisted liquid-liquid microextraction coupled with GC-IT/MS (UVALLME-GC-IT/MS). Particularly, the whole procedure allows the determination of six phthalates such as DMP, DEP, DBP, iBcEP, BBP and DEHP. After dissolution of 0.1g product sample and addition of anthracene as Internal Standard, 250μL of n-heptane are used as extraction solvent...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28300960/brazilian-portuguese-hearing-in-noise-test-hint-different-interpretation-criteria-for-individuals-responses
#15
Rafaela do Couto Melo, Denise Costa Menezes, Fernando Augusto Pacífico, Karina Paes Advíncula, Silvana Maria Sobral Griz
Introduction: The ability to recognize the sounds of speech enables an efficient communication. This ability must always be considered when communication disorders are evaluated. In this study, sentences of the Hearing in Noise Test (HINT), originally developed in English and adapted to Brazilian Portuguese, were used to evaluate speech recognition in silence and in the presence of noise. Although this test can be an important clinical tool, it is noticed that it has not been used in audiological clinical practice in Brazil...
March 9, 2017: CoDAS
https://www.readbyqxmd.com/read/28300957/dosage-dependent-effect-of-high-resistance-straw-exercise-in-dysphonic-and-non-dysphonic-women
#16
Sabrina Mazzer Paes, Mara Behlau
Purpose: to study the dosage dependent effect of high-resistance straw exercise in women with behavioral dysphonia and in vocally healthy women. Methods: 25 dysphonic women (DG), with average age of 35 years (SD = 10.5) and 30 vocally healthy women (VHG), with average age of 31.6 years (SD = 10.3). The participants produced a continuous sound into a thin high-resistance straw for seven minutes, being interrupted after the first, third, fifth and seventh minute. At each interval, speech samples were recorded (sustained vowel and counting up to 20) and subsequently acoustically analyzed...
March 9, 2017: CoDAS
https://www.readbyqxmd.com/read/28299338/antithrombotic-effect-and-mechanism-of-radix-paeoniae-rubra
#17
Pingyao Xie, Lili Cui, Yuan Shan, Wen-Yi Kang
The compounds of Radix Paeoniae Rubra (RPR) were isolated and identified by bioassay-guided method, and antithrombotic effects and mechanism were investigated by the acute blood stasis rat model. The RPR extract was evaluated by APTT, TT, PT, and FIB assays in vitro. Results indicated that RPR extract exhibited the anticoagulant activity. In order to find active compounds, six compounds were isolated and identified, and four compounds, paeoniflorin (Pae), pentagalloylglucose (Pen), albiflorin (Ali), and protocatechuic acid (Pro), exhibited the anticoagulant activity in vitro...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28294365/prevalence-of-prenatal-alcohol-exposure-in-the-state-of-texas-as-assessed-by-phosphatidylethanol-in-newborn-dried-blood-spot-specimens
#18
Ludmila N Bakhireva, Janet Sharkis, Shikhar Shrestha, Tristan J Miranda-Sohrabji, Sonnie Williams, Rajesh C Miranda
BACKGROUND: While 2-5% of school-aged children in the U.S. are estimated to be affected by Fetal Alcohol Spectrum Disorders (FASD), the prevalence of prenatal alcohol exposure (PAE) might be substantially under-reported. Our objective was to systematically estimate the prevalence of PAE in Texas by measuring a direct ethanol metabolite, phosphatidylethanol (PEth), in 1,000 infant residual dried blood spots (irDBS) in the Texas Newborn Screening Repository. METHODS: All Public Health Regions were represented proportional to their 2014 birth rate (~0...
March 13, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28284886/role-of-coil-embolization-during-prostatic-artery-embolization-incidence-indications-and-safety-profile-%C3%A2
#19
Shivank Bhatia, Vishal Sinha, Matthew Bordegaray, Issam Kably, Sardis Harward, Govindarajan Narayanan
PURPOSE: To determine if coil embolization is a safe adjunctive measure to prevent nontarget embolization during prostatic artery embolization (PAE). MATERIALS AND METHODS: A retrospective analysis of patients who underwent PAE with coil embolization (cPAE) or without coil embolization (nPAE) between January 2014 and June 2016 was conducted. Adverse events, identified in accordance with SIR guidelines, and procedural variables were compared between the 2 cohorts...
March 8, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28284605/pro-apoptotic-effect-of-a-mycoplasma-hyopneumoniae-putative-type-i-signal-peptidase-on-pk-15-swine-cells
#20
Jéssica A Paes, Veridiana G Virginio, Martín Cancela, Fernanda M A Leal, Thiago J Borges, Natália Jaeger, Cristina Bonorino, Irene S Schrank, Henrique B Ferreira
Mycoplasma hyopneumoniae is an economically significant swine pathogen that causes porcine enzootic pneumonia (PEP). Important processes for swine infection by M. hyopneumoniae depend on cell surface proteins, many of which are secreted by secretion pathways not completely elucidated so far. A putative type I signal peptidase (SPase I), a possible component of a putative Sec-dependent pathway, was annotated as a product of the sipS gene in the pathogenic M. hyopneumoniae 7448 genome. This M. hyopneumoniae putative SPase I (MhSPase I) displays only 14% and 23% of sequence identity/similarity to Escherichia coli bona fide SPase I, and, in complementation assays performed with a conditional E...
March 2017: Veterinary Microbiology
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