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Heitham Wady, Zain Badar, Zerwa Farooq, Palma Shaw, Katsuhiro Kobayashi
Popliteal artery entrapment syndrome (PAES), a condition predominantly affecting young individuals, is a rare clinical entity that can result in significant morbidity. The presence of lower limb pain and claudication in young, physically active individuals should prompt consideration for PAES. Early diagnosis and management is crucial to prevent long-term complications; however, diagnosis is fraught with challenges due to the rarity of the disease and its similar clinical presentation with more common conditions...
2018: Case Reports in Medicine
Marco Aurélio Petroni Montezuma, Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Rosana Lima Pagano, Eduardo Rodrigues Fregnani
Ameloblastoma is a locally aggressive neoplasm with a poorly understood pathogenesis. Therefore, the aim of this study is to investigate whether COX-2 expression is associated with ameloblastoma microvascular density (MVD) and with tumor aggressiveness. Sixty-three cases of primary ameloblastomas arranged in tissue microarray were submitted to immunohistochemistry against cyclooxigenase-2 (COX-2) and CD34. Clinicopathological parameters regarding sex, age, tumour size, tumour duration, tumour location, treatment, recurrences, radiographic features, vestibular/lingual and basal cortical disruption and follow-up data were obtained from patients' medical records and correlated with the proteins expression...
March 15, 2018: Pathology, Research and Practice
Candice Bjornson, Parco Chan, Abby Li, Bosco Paes, Krista L Lanctôt, Ian Mitchell
Respiratory syncytial virus (RSV) infection in cystic fibrosis (CF) infants is associated with significant morbidities. This study's objective is to evaluate the effectiveness and adverse events related to palivizumab (PVZ) in CF infants. Data on respiratory-related illness (RIH) and RSV hospitalizations (RSVH) were collected retrospectively in CF infants aged < 2 years in Alberta, Canada, from 2000 to 2017. Logistic regression models were used to compare the odds of RSVH or RIH in PVZ infants from the Canadian registry of palivizumab (CARESS) versus untreated (UPVZ) infants from Alberta, after adjusting for potential confounders...
March 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Jaan Pärn, Jos T A Verhoeven, Klaus Butterbach-Bahl, Nancy B Dise, Sami Ullah, Anto Aasa, Sergey Egorov, Mikk Espenberg, Järvi Järveoja, Jyrki Jauhiainen, Kuno Kasak, Leif Klemedtsson, Ain Kull, Fatima Laggoun-Défarge, Elena D Lapshina, Annalea Lohila, Krista Lõhmus, Martin Maddison, William J Mitsch, Christoph Müller, Ülo Niinemets, Bruce Osborne, Taavi Pae, Jüri-Ott Salm, Fotis Sgouridis, Kristina Sohar, Kaido Soosaar, Kathryn Storey, Alar Teemusk, Moses M Tenywa, Julien Tournebize, Jaak Truu, Gert Veber, Jorge A Villa, Seint Sann Zaw, Ülo Mander
Nitrous oxide (N2 O) is a powerful greenhouse gas and the main driver of stratospheric ozone depletion. Since soils are the largest source of N2 O, predicting soil response to changes in climate or land use is central to understanding and managing N2 O. Here we find that N2 O flux can be predicted by models incorporating soil nitrate concentration (NO3 - ), water content and temperature using a global field survey of N2 O emissions and potential driving factors across a wide range of organic soils. N2 O emissions increase with NO3 - and follow a bell-shaped distribution with water content...
March 19, 2018: Nature Communications
Hu Cheng, Yang Song, Fang Wang, Rongting Ji, Xiaona Li, Yuhao Fu, Xinglun Yang, Yongrong Bian, Xin Jiang
Porous materials have great prospective applications for solid-phase microextraction (SPME) technology because of their large specific surface area and pore volume. In this study, a hierarchical porous carbon (HPC) was synthesized by simple hydrothermal reaction and potassium hydroxide (KOH) activation of crude biomass and found to be an efficient adsorbent for SPME of organic pollutants. Results show that the as-prepared HPC has a partly graphitic amorphous-like structure with ultrahigh specific surface area (2551 m2 /g), high pore volume (1...
March 13, 2018: Journal of Chromatography. A
Alessandro Antônio Costa Pereira, Christian Barros Ferreira, João Adolfo Costa Hanemann, Livia Maris Ribeiro Paranaiba, Patricia Peres Iucif Pereira, Carla Isabelly Rodrigues-Fernandes, Celeste Sánchez-Romero, Oslei Paes de Almeida, Felipe Paiva Fonseca
Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein-Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult...
March 14, 2018: Head and Neck Pathology
Kazuyuki Komori, Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
PURPOSE: We evaluated the feasibility of surgery for pulmonary aspergilloma. METHODS: We retrospectively evaluated 35 surgical patients with pulmonary aspergilloma. The clinical characteristics and perioperative surgical morbidity were compared based on the operative modes. Preoperative artery embolization (PAE) was selectively performed to reduce the expected surgical stress caused by intraoperative blood loss. RESULTS: The cohort comprised 19 males and 16 females with a mean age of 56 years...
March 14, 2018: General Thoracic and Cardiovascular Surgery
Ludmila N Bakhireva, Jean Lowe, Laura M Garrison, Sandra Cano, Yuridia Leyva, Fares Qeadan, Julia M Stephen
INTRODUCTION: Earlier identification of children with prenatal alcohol exposure (PAE) remains a challenge. The objective of this study was to identify neurobehavioral (NB) outcomes associated with PAE in infants. METHODS: This manuscript evaluates NB outcomes at 6.33±1.12 months of age in 93 infants (39 PAE and 54 No-PAE) recruited prospectively into the ENRICH cohort. PAE was assessed by prospective repeated TLFB interviews and a panel of ethanol biomarkers. NB outcomes were evaluated by the Bayley Scales of Infant Development (BSID-III), Parenting Stress Index (PSI), Infant Behavior Questionnaire (IBQ-R), and Infant Sensory Profile (ISP)...
March 14, 2018: Pediatric Research
Shamar Young, Jafar Golzarian
PURPOSE OF REVIEW: Over the last several years prostate artery embolization (PAE) has been developed as a minimally invasive technique for the treatment of benign prostatic hyperplasia induced lower urinary tract symptoms. This review aims to elucidate the data available on this developing technique and identify areas requiring further investigation. RECENT FINDINGS: Recent studies have demonstrated that PAE is able to deliver excellent clinical outcomes in terms of International Prostate Symptom Score, quality-of-life score, maximum urinary flow rate, post-void residual, and prostate volume reduction...
March 13, 2018: Current Opinion in Urology
Julia M Stephen, Lucinda Flynn, Danielle Kabella, Megan Schendel, Sandra Cano, Daniel D Savage, William Rayburn, Lawrence M Leeman, Jean Lowe, Ludmila N Bakhireva
Early identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individuals without facial dysmorphia make up the majority of individuals affected by PAE. This study employed a prospective cohort design to capture alcohol consumption patterns during pregnancy and then followed the infants to 6 months of age...
2018: NeuroImage: Clinical
Ga Young Lee, Chan Yoon Park, Kyeong Sun Cha, Seung Eun Lee, Munkyong Pae, Sung Nim Han
Vitamin D has an immunoregulatory effect on both innate and adaptive immunity. Contradictory results regarding vitamin D and natural killer (NK) cell functions have been reported with in vitro studies, but little is known about this in vivo. We investigated whether vitamin D levels (50, 1000 or 10,000 IU/kg of diet: DD, DC or DS) affect NK cell functions in mice fed a control or high-fat diet (10% or 45% kcal fat: CD or HFD) for 12 weeks. The splenic NK cell activity was significantly higher in the CD-DS group than the HFD-DS group, and the CD-DS group showed significantly higher NK cell activity compared with the CD-DD and CD-DC groups...
January 31, 2018: Journal of Nutritional Biochemistry
Javier González-Sálamo, Miguel Ángel González-Curbelo, Bárbara Socas-Rodríguez, Javier Hernández-Borges, Miguel Ángel Rodríguez-Delgado
A new hollow fiber liquid-phase microextraction (HF-LPME) method has been developed for the extraction of a group of phthalic acid esters (PAEs) of interest from different water samples prior to gas chromatography tandem mass spectrometry analysis. HF-LPME was carried out using 1-octanol as extraction solvent followed by a back extraction step with cyclohexane. The different parameters that affect HF-LPME such as sample pH, ionic strength, extraction time, stirring rate, extraction temperature and back extraction conditions were investigated...
March 1, 2018: Chemosphere
Mingyi Zhao, Peng Zhou, Jun Yu, Asenso James, Feng Xiao, Chun Wang, Wei Wei
Paeoniflorin-6'-O-benzene sulfonate (code: CP-25) is a novel ester derivative of paeoniflorin (Pae). Compared to Pae, CP-25 has higher lipid solubility, bioavailability and better bioactivity. However, the tissue distribution and excretion of CP-25 still remain unknown. The LC-MS method was applied to investigate the tissue distribution and excretion of CP-25 in rats. As such, 50 mg/kg of CP-25 and Pae were administered to rats in multiple doses via an oral route. CP-25 and Pae were distributed widely and rapidly in all the tested tissues...
March 9, 2018: Inflammopharmacology
Fiona Ma MacCormick, Charlotte Emmett, Paul Paes, Julian C Hughes
BACKGROUND: Concerns about decision making related to resuscitation have led to two important challenges in the courts resulting in new legal precedents for decision-making practice. Systematic research investigating the experiences of doctors involved in decisions about resuscitation in light of the recent changes in law remains lacking. AIM: To analyse the practice of resuscitation decision making on hospital wards from the perspectives of doctors. DESIGN: The data presented in this paper were collected as part of a wider research study of end-of-life care in an acute hospital setting...
March 9, 2018: Journal of Medical Ethics
Eduardo Lattari, Henning Budde, Flávia Paes, Geraldo Albuquerque Maranhão Neto, José Carlos Appolinario, Antônio Egídio Nardi, Eric Murillo-Rodriguez, Sérgio Machado
Background: The effects of the aerobic exercise on anxiety symptoms in patients with Panic Disorder (PD) remain unclear. Thus, the investigation of possible changes in EEG frontal asymmetry could contribute to understand the relationship among exercise, brain and anxiety. Objective: To investigate the acute effects of aerobic exercise on the symptoms of anxiety and the chronic effects of aerobic exercise on severity and symptoms related to PD, besides the changes in EEG frontal asymmetry...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Marcio Amaral de Oliveira Filho, Denise Machado Medeiros, Adriano Gomes-Silva, Jéssica Ribeiro de Lima, Alda Maria Da-Cruz, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Muzafar Ahmad Rather, Zubair Shanib Bhat, Ali Mohd Lone, Mubashir Maqbool, Shajrul Amin, Bilal Ahmad Bhat, Zahoor Ahmad
The presented study reports in vitro antituberculosis potential of 2-(((2-hydroxyphenyl) amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (PAMCHD) against Mycobacterium tuberculosis H37Rv. PAMCHD proved to be tuberculostatic as well as tuberculocidal agent by agar and broth dilution methods with MIC and MBC values equivalent to some standard antituberculosis drugs (ATDs). The dynamics of M. tuberculosis killing revealed its time as well as concentration dependent antituberculosis activity and it sterilized M...
March 3, 2018: International Journal of Antimicrobial Agents
Giuseppe Giannaccare, Laura Primavera, Michela Fresina
PURPOSE: To evaluate refractive, binocular vision and ocular alignment outcomes of photorefractive keratectomy (PRK) for the treatment of hyperopia in esotropic patients. METHODS: Medical charts of hyperopic patients with full or partial accommodative esotropia (FAE or PAE) or consecutive exotropia (CE) undergone PRK from 2011 to 2014 were reviewed. The primary outcome was to assess the efficacy of PRK in improving ocular alignment. The secondary outcomes were the assessments of uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical equivalent (SE) and stereoacuity...
March 3, 2018: International Ophthalmology
Marisol Miranda Galvis, Juscelino Freitas Jardim, Estela Kaminagakura, Alan Roger Santos-Silva, Felipe Paiva Fonseca, Oslei Paes Almeida, Marcio Ajudarte Lopes, Clóvis Lópes Pinto, Luiz Paulo Kowalski
OBJECTIVE: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients...
February 2, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Yongfeng Xu, Shixiang Dai, Ke Meng, Yuting Wang, Wenjie Ren, Ling Zhao, Peter Christie, Ying Teng
The residual levels and risk assessment of several potentially toxic elements (PTEs), phthalate esters (PAEs) and polycyclic aromatic hydrocarbons (PAHs) in rural soils near different types of pollution sources in Tianjin, China, were studied. The soils were found to be polluted to different extents with PTEs, PAEs and PAHs from different pollution sources. The soil concentrations of chromium (Cr), nickel (Ni), di-n-butyl phthalate (DnBP), acenaphthylene (Any) and acenaphthene (Ane) were higher than their corresponding regulatory reference limits...
February 26, 2018: Science of the Total Environment
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