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https://www.readbyqxmd.com/read/29330246/the-accuracy-of-trigger-tools-to-detect-preventable-adverse-events-in-primary-care-a-systematic-review
#1
Joshua Davis, Nicole Harrington, Heather Bittner Fagan, Barbara Henry, Margot Savoy
PURPOSE: To understand the ability of trigger tools to detect preventable adverse events (pAEs) in the primary care outpatient setting using the Institute for Healthcare Improvement's (IHI) Outpatient Adverse Event Trigger Tool (IHI Tool). METHODS: The OVID MEDLINE and OVID MEDLINE In-process and non-Indexed citations databases were queried using controlled vocabulary and Medical Subject Headings related to the concepts "primary care" and "adverse events." Included articles were conducted in the outpatient setting, used at least 1 of the triggers identified in the IHI Tool, and identified pAEs of any type...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29328989/inhibition-of-udp-glucuronosyltransferases-ugts-by-phthalate-monoesters
#2
Zuo Du, Yun-Feng Cao, Sai-Nan Li, Cui-Min Hu, Zhi-Wei Fu, Chun-Ting Huang, Xiao-Yu Sun, Yong-Zhe Liu, Kun Yang, Zhong-Ze Fang
Phthalate monoesters are important metabolites of phthalate esters (PAEs) which have been extensively utilized in industry. This study aims to investigate the inhibition of phthalate monoesters on the activity of various isoforms of UDP-glucuronosyltransferases (UGTs), trying to elucidate the toxicity mechanism of environmental endocrine disruptors from the new perspectives. In vitro recombinant UGTs-catalyzed glucuronidation of 4-methylumbelliferone (4-MU) was employed to evaluate 8 kinds of phthalate monoesters on 11 sorts of main human UGT isoforms...
January 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29326898/effect-of-10-weight-loss-on-simulated-taekwondo-match-performance-a-randomized-trial
#3
Leonardo de Sousa Fortes, Gustavo César de Vasconcelos, Bruna Daniella de Vasconcelos Costa, Pedro Pinheiro Paes, Emerson Franchini
The objective of the present study was to analyze the effect of 10% body mass reduction on simulated taekwondo match performance. Thirty-one male taekwondo athletes were randomly distributed in two groups: weight loss group (n= 15) - athletes in this group reduced 5% body mass per week during two successive weeks, totaling 10% body mass reduction; control group (n= 16) - athletes in this group kept their body mass constant during the 2-week period. Twenty-four hours before and after this period, athletes performed a simulated 3-round taekwondo match (6 min)...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29324964/family-conference-in-palliative-care-concept-analysis
#4
Rudval Souza da Silva, Géssica Sodré Sampaio Trindade, Gilvânia Patrícia do Nascimento Paixão, Maria Júlia Paes da Silva
OBJECTIVE: to analyze the attributes, antecedents and consequents of the family conference concept. METHOD: Walker and Avante's method for concept analysis and the stages of the integrative review process, with a selection of publications in the PubMed, Cinahl and Lilacs databases focusing on the family conference theme in the context of palliative care. RESULTS: the most cited antecedents were the presence of doubts and the need to define a care plan...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324962/care-provided-by-the-father-to-the-child-with-cancer-under-the-influence-of-masculinities-qualitative-meta-synthesis
#5
Naiara Barros Polita, Willyane de Andrade Alvarenga, Ana Carolina Andrade Biaggi Leite, Jeferson Santos Araújo, Louise Bittencourt Paes Abreu Dos Santos, Márcia Maria Fontão Zago, Francine de Montigny, Lucila Castanheira Nascimento
OBJECTIVE: To synthesize and interpret findings and conclusions of qualitative research addressing the experience of the father in the care of the child with cancer. METHOD: Meta-synthesis of 16 qualitative studies from six databases, analyzed through taxonomic analysis. RESULTS: Child and adolescent cancer have several repercussions on the daily life of the father, especially related to the stigma around the disease, the fear of the unknown and the social and family role...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324958/enhancing-the-process-of-teaching-and-learning-homecare
#6
Ana Paula Hermann, Maria Ribeiro Lacerda, Jaqueline Dias do Nascimento, Ingrid Meireles Gomes, Débora Cristina Paes Zatoni
OBJECTIVE: to identify possibilities for improvement in the process of teaching and learning homecare in nursing, pharmacy, medicine, nutrition, dentistry and occupational therapy courses. METHOD: qualitative research using the Grounded Theory approach. Sixty-three semi-structured interviews were conducted with students, teachers and graduates of the six mentioned courses at a public university in the south of Brazil. Data analysis was performed through open, axial and selective coding...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29321952/fasciculation-and-elongation-zeta-1-protein-fez1-interacts-with-the-retinoic-acid-receptor-and-participates-in-transcriptional-regulation-of-the-hoxb4-gene
#7
Mariana Bertini Teixeira, Ana Carolina M Figueira, Ariane S Furlan, Bruno Aquino, Marcos R Alborghetti, Adriana F Paes Leme, Li-Na Wei, Jörg Kobarg
Fasciculation and elongation zeta-1 (FEZ1) protein is involved in axon outgrowth and is highly expressed in the brain. It has multiple interaction partners, with functions varying from the regulation of neuronal development and intracellular transport mechanisms to transcription regulation. One of its interactors is retinoic acid receptor (RAR), which is activated by retinoic acid and controls many target genes and physiological process. Based on previous evidence suggesting a possible nuclear role for FEZ1, we wanted to deepen our understanding of this function by addressing the FEZ1-RAR interaction...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29316941/homocysteine-folate-hs-c-reactive-protein-tumor-necrosis-factor-alpha-and-inflammatory-proteins-are-these-biomarkers-related-to-nutritional-status-and-cardiovascular-risk-in-childhood-onset-systemic-lupus-erythematosus
#8
Roberta Garcia Salomão, Luciana Martins de Carvalho, Clarice Izumi, Érika Silva Czernisz, José César Rosa, Sonir Roberto Rauber Antonini, Ana Carolina Bueno, Maria Olímpia Ribeiro do Vale Almada, Carolina de Almeida Coelho-Landell, Alceu Afonso Jordão, Virgínia Paes Leme Ferriani, Jacqueline Pontes Monteiro
BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers...
January 9, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29316822/beneficial-anti-inflammatory-effect-of-paeonol-self-microemulsion-loaded-colon-specific-capsules-on-experimental-ulcerative-colitis-rats
#9
Shiyu Zong, Yiqiong Pu, Suyun Li, Benliang Xu, Yong Zhang, Tong Zhang, Bing Wang
Paeonol, as the main phenolic compound isolated from the Chinese herbs, has been confirmed to present anti-inflammatory effects on ulcerative colitis (UC) in our previous study. However, its poor solubility has hindered its development of being a favourable pharmaceutical product in treating colon diseases. In this study, we prepared the colon-specific delivery system (Pae-SME-CSC) with paeonol-loaded self-microemulsion (Pae-SMEDDS), and evaluated its in vitro and in vivo properties, especially the anti-inflammatory effects on UC rats...
January 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29316477/challenges-of-diagnosing-fetal-alcohol-spectrum-disorders-in-foster-and-adopted-children
#10
Ludmila N Bakhireva, Laura Garrison, Shikhar Shrestha, Janet Sharkis, Rajesh Miranda, Karen Rogers
Fetal Alcohol Spectrum Disorders (FASD) might be 10-15 times more prevalent among foster/adopted children compared to the general population; however, many of these children remain undiagnosed or misdiagnosed. The lack of confirmed prenatal alcohol exposure (PAE) may be a key barrier to diagnosis. Our sample included 681 patients evaluated for FASD, according to the University of Washington 4-Digit Diagnostic Code, at a pediatric specialty clinic. Guardianship status and other patient characteristics were evaluated by multinomial logistic regression as potential predictors of being classified into one of the following FASD groups: 1) full or partial Fetal Alcohol Syndrome (FAS/pFAS; n = 97); 2) Static Encephalopathy/Alcohol-Exposed (SE/AE) or Neurobehavioral Disorder/Alcohol-Exposed (ND/AE) (n = 135); and 3) some features of FASD (equivalent to pFAS, SE/AE or ND/AE phenotypes) but unknown PAE (n = 449)...
August 24, 2017: Alcohol
https://www.readbyqxmd.com/read/29316409/exercise-is-medicine-canada-physical-activity-counselling-and-exercise-prescription-training-improves-counselling-prescription-and-referral-practices-among-physicians-across-canada
#11
Jonathon R Fowles, Myles W O'Brien, Kara Solmundson, Paul I Oh, Christopher A Shields
Exercise is Medicine Canada (EIMC) is an initiative that promotes physical activity (PA) counselling and exercise prescription within health care. The purpose of this study was to compare physicians' perceptions and practices around PA counselling and exercise prescription following EIMC training. Physicians (n=46) from 7 different provinces completed questionnaires initially and three-months following an EIMC workshop. Three-months post-intervention, physicians reported greater confidence compared to baseline, for providing physical activity and exercise (PAE) information to patients (79% vs 55%; p<0...
January 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29315974/microdialysis-sampling-combined-with-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-the-determination-of-geniposide-in-dialysate-of-joint-cavities-in-adjuvant-arthritis-rats
#12
Wen-Yu Wang, Wei Wang, Hong Wu, Shu-Ping Li, Rong Wang, Li Dai, Zheng-Rong Zhang, Jun Fu, Ran Deng, Feng Li
RATIONALE: Microdialysis has been used to detect the concentrations of drugs in tissues. Geniposide (GE), an iridoid glycoside compound, is the main bioactive component of Gardenia jasminoides Ellis fruit. We previously demonstrated that GE could control the activity of cytokines and reduce levels of inflammation in adjuvant arthritis (AA) rats, but the topic of concentration changes over time in the joint synovia of AA is scarcely studied. METHODS: In this study, microdialysis technique combined with ultra-high-performance liquid chromatography-electrospray ionization coupled with tandem mass spectrometry (UHPLC-ESI-MS/MS) was set up and confirmed to assay GE in the dialysate of the joint cavity in AA rats...
January 5, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29315624/prenatal-alcohol-exposure-increases-histamine-h3-receptor-mediated-inhibition-of-glutamatergic-neurotransmission-in-rat-dentate-gyrus
#13
Rafael K Varaschin, Nyika A Allen, Martina J Rosenberg, C Fernando Valenzuela, Daniel D Savage
BACKGROUND: We have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine H3 receptor inverse agonist ABT-239. Curiously, ABT-239 did not enhance LTP or memory in control offspring. Here, we initiated an investigation of how PAE alters histaminergic neurotransmission in the dentate gyrus and other brain regions employing combined radiohistochemical and electrophysiological approaches in vitro to examine histamine H3 receptor number and function...
December 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29311538/popliteal-artery-entrapment-syndrome-a-case-report-and-review-of-the-literature
#14
Francisco Cialdine Frota Carneiro Júnior, Eduardo Nazareno Dos Anjos Carrijo, Samuel Tomaz Araújo, Luis Carlos Uta Nakano, Jorge Eduardo de Amorim, Daniel Guimarães Cacione
BACKGROUND Popliteal artery entrapment syndrome (PAES) results from an anomalous relationship between the popliteal artery and the myofascial structures of the popliteal fossa. The most common presenting symptoms include intermittent pain in the feet and calves on exercise, resulting in lameness. PAES can lead to popliteal artery thrombosis, stenosis, distal arterial thromboembolism, or arterial aneurysm. The treatment of PAES includes surgical exploration with fasciotomy, myotomy, or sectioning of fibrous band formation, to release the popliteal artery...
January 9, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29309652/proline-rich-antimicrobial-peptides-show-a-long-lasting-post-antibiotic-effect-on-enterobacteriaceae-and-pseudomonas-aeruginosa
#15
Luzia Holfeld, Daniel Knappe, Ralf Hoffmann
Background: Proline-rich antimicrobial peptides (PrAMPs) represent a promising class of potential therapeutics to treat multiresistant infections. They inhibit bacterial protein translation at the 70S ribosome by either blocking the peptide-exit tunnel (oncocin type) or trapping release factors (apidaecin type). Objectives: Besides direct concentration-dependent antibacterial effects, the post-antibiotic effect (PAE) is the second most important criterion of antimicrobial pharmacodynamics to be determined in vitro...
December 21, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29291449/health-risk-assessment-of-reclaimed-wastewater-a-case-study-of-a-conventional-water-reclamation-plant-in-nanjing-china
#16
Yongfeng Deng, Melvin Bonilla, Hongqiang Ren, Yan Zhang
Contaminated reclaimed wastewater has the potential to induce adverse effects on the health of wastewater workers and residents. However, few studies have focused on these health risks. In this study, we assessed the health risk of samples collected from different treatment processing units used in a typical water reclamation plant in Nanjing, China. Chemical analysis revealed that 40 semi-volatile organic compounds (SVOCs) and 6 N-nitrosamines (NAs) persisted after wastewater treatment. A health risk assessment revealed that the SVOCs in effluents pose negligible non-carcinogenic risk to wastewater workers and local residents as both the hazard quotient (HQ) and hazard index (HI) were all below 1...
December 29, 2017: Environment International
https://www.readbyqxmd.com/read/29291185/disparity-in-opinions-on-lip-protrusiveness-in-contemporary-african-american-faces
#17
Yvette Battle, Monica Schneider, Laurence Magder, Eung-Kwon Pae
Objective: In accordance with the changing demographics in the United States, orthodontists working on various ethnic populations should be more conscious when using the standardized profile analyses for the African American patient. The objective of this study was to examine whether the perception of lip protrusiveness in modern African American faces has changed. For this purpose, we investigated the most favorable African American lip profile using the opinions of 10 experienced and 10 newly trained younger orthodontists...
January 2018: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29289490/positive-end-expiratory-pressure-during-resuscitation-at-birth-in-very-low-birth-weight-infants-a-randomized-controlled-pilot-trial
#18
Ratchada Kitsommart, Kittaya Nakornchai, Buranee Yangthara, Ratchada Jiraprasertwong, Bosco Paes
BACKGROUND: There is limited evidence of the effect of positive end-expiratory pressure (PEEP) during resuscitation soon after birth. Premature neonates may experience respiratory distress from surfactant insufficiency and providing PEEP after the very first breath, may improve outcomes following appropriate resuscitation. The objective of this study was to evaluate the short term respiratory outcomes after positive pressure ventilation (PPV) with PEEP in preterm infants at birth. METHODS: A prospective randomized-controlled, pilot trial was conducted...
December 9, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29288949/synthesis-and-evaluation-of-2-3-arylureido-pyridines-and-2-3-arylureido-pyrazines-as-potential-modulators-of-a%C3%AE-induced-mitochondrial-dysfunction-in-alzheimer-s-disease
#19
Ahmed Elkamhawy, Jung-Eun Park, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Beoung-Geon Park, Eun Joo Roh
A series of 2-(3-arylureido)pyridines and 2-(3-benzylureido)pyridines were synthesized and evaluated as potential modulators for amyloid beta (Aβ)-induced mitochondrial dysfunction in Alzheimer's disease (AD). The blocking activities of forty one small molecules against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The inhibitory activity of twenty five compounds against Aβ-induced mPTP opening was superior to that of the standard cyclosporin A (CsA)...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29285703/phthalate-esters-in-surface-water-of-songhua-river-watershed-associated-with-land-use-types-northeast-china
#20
Zhidan Wen, Xiaoli Huang, Dawen Gao, Ge Liu, Chong Fang, Yingxin Shang, Jia Du, Ying Zhao, Lili Lv, Kaishan Song
The ubiquitous presence of phthalate esters (PAEs) in the environment and their potential role as endocrine disruptors of marine organisms has attracted much attention. The presence of PAEs in different water sources collected from the Songhua River mainstream and its tributaries has been determined in this study. The total concentration of the seven PAEs (∑PAEs) detected was found to range from 1.153 to 7.867 μg L-1, with di(2-ethylhexyl) phthalate (DEHP) present as the predominate PAE congener. Dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), and DEHP were present in all of the water samples analyzed...
December 28, 2017: Environmental Science and Pollution Research International
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