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https://www.readbyqxmd.com/read/28101142/exploring-accessibility-of-pretreated-poplar-cell-walls-by-measuring-dynamics-of-fluorescent-probes
#1
Gabriel Paës, Anouck Habrant, Jordane Ossemond, Brigitte Chabbert
BACKGROUND: The lignocellulosic cell wall network is resistant to enzymatic degradation due to the complex chemical and structural features. Pretreatments are thus commonly used to overcome natural recalcitrance of lignocellulose. Characterization of their impact on architecture requires combinatory approaches. However, the accessibility of the lignocellulosic cell walls still needs further insights to provide relevant information. RESULTS: Poplar specimens were pretreated using different conditions...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28098942/biomarkers-for-the-detection-of-prenatal-alcohol-exposure-a-review
#2
REVIEW
Heidi Bager, Lars Porskjaer Christensen, Steffen Husby, Lene Bjerregaard
Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self-reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self-reporting. This review reports on clinically relevant biomarkers for detection of prenatal alcohol exposure (PAE)...
January 18, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28098256/dopamine-promotes-nmda-receptor-hypofunction-in-the-retina-through-d1-receptor-mediated-csk-activation-src-inhibition-and-decrease-of-glun2b-phosphorylation
#3
Renato Socodato, Felipe N Santiago, Camila C Portugal, Ivan Domith, Thaísa G Encarnação, Erick C Loiola, Ana L M Ventura, Marcelo Cossenza, João B Relvas, Newton G Castro, Roberto Paes-de-Carvalho
Dopamine and glutamate are critical neurotransmitters involved in light-induced synaptic activity in the retina. In brain neurons, dopamine D1 receptors (D1Rs) and the cytosolic protein tyrosine kinase Src can, independently, modulate the behavior of NMDA-type glutamate receptors (NMDARs). Here we studied the interplay between D1Rs, Src and NMDARs in retinal neurons. We reveal that dopamine-mediated D1R stimulation provoked NMDAR hypofunction in retinal neurons by attenuating NMDA-gated currents, by preventing NMDA-elicited calcium mobilization and by decreasing the phosphorylation of NMDAR subunit GluN2B...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094218/cribriform-adenocarcinoma-of-the-soft-palate-with-multiple-lymph-node-metastasis-and-long-term-follow-up
#4
Fernanda Viviane Mariano, Renata Freitas Varanda, Luciana Schultz, Marcelo Brum Correa, Oslei Paes de Almeida, Albina Atemani, Márcio Ajudarte Lopes
INTRODUCTION: Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma. OBJECTIVE: To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior...
November 1, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28092763/growth-and-antioxidant-defense-responses-of-wheat-seedlings-to-di-n-butyl-phthalate-and-di-2-ethylhexyl-phthalate-stress
#5
Minling Gao, Youming Dong, Ze Zhang, Wenhua Song, Yun Qi
Phthalate acid esters (PAEs) are vital environmental hormone-like chemicals that are noxious to plants, animals, and human beings. In this study, the influences of di-n-butyl phthalate (DBP) and di (2-ethylhexyl) phthalate (DEHP) on the seed germination, root morphology, and various physiological changes of wheat seedlings were investigated by analyzing superoxide anion (O2(-)) accumulation, antioxidant enzyme activity, and lipid peroxidation. DBP and DEHP were found to obviously inhibit germination only at high concentrations, but significantly affected root morphology even at lower concentrations...
January 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28078517/semivolatile-organic-compounds-in-surface-microlayer-and-subsurface-water-of-dianshan-lake-shanghai-china-implications-for-accumulation-and-interrelationship
#6
Ming-Hong Wu, Xue-Xia Yang, Gang Xu, Chen-Jing Que, Si-Han Ma, Liang Tang
Semivolatile organic compounds (SVOCs) in surface microlayer (SML) and subsurface water (SSW) from Dianshan Lake were studied to investigate their occurrence, distributions, as well as enrichment and potential sources. A sample was concentrated by solid-phase micro-extraction (SPME). Identification and quantification were carried out by gas chromatography coupled to mass spectrometry (GC-MS). Total SVOCs concentrations ranged from 25.93 to 47.49 μg/L in SSW and 38.19 to 77.23 μg/L in SML. The phthalic acid esters (PAE) concentrations in both SSW and SML are the highest of the total SVOC...
January 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28078431/degradation-of-di-2-ethylhexyl-phthalate-by-a-novel-gordonia-alkanivorans-strain-yc-rl2
#7
Ruth Nahurira, Lei Ren, Jinlong Song, Yang Jia, Junhuan Wang, Shuanghu Fan, Haisheng Wang, Yanchun Yan
One bacterial strain, YC-RL2, isolated from petroleum-contaminated soil, could utilize environmental hormone Di(2-Ethylhexyl) phthalate (DEHP) as a sole carbon source for growth. Strain YC-RL2 was identified as Gordonia alkanivorans by 16S rRNA gene analysis and Biolog tests. The effects of environmental factors which might affect the degrading process were optimized at 30 °C and pH 8.0. Strain YC-RL2 showed superior halotolerance and could tolerate up to 0-5% NaCl in trace element medium supplemented with DEHP, although the DEHP degradation rates slowed as NaCl concentration increased...
January 12, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28074310/recurrence-of-lower-urinary-tract-symptoms-following-prostate-artery-embolization-for-benign-hyperplasia-single-center-experience-comparing-two-techniques
#8
Francisco Cesar Carnevale, Airton Mota Moreira, Sardis Honoria Harward, Shivank Bhatia, Andre Moreira de Assis, Miguel Srougi, Giovanni Guido Cerri, Alberto Azoubel Antunes
PURPOSE: To compare recurrence of lower urinary tract symptoms (LUTS) recurrence at 12 months following original prostate artery embolization (oPAE) or "proximal embolization first, then embolize distal" (PErFecTED) PAE for benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: 105 consecutive patients older than 45 years, with prostate size greater than 30 cm(3), International Prostate Symptom Score (IPSS) ≥ 8, quality of life (QoL) index ≥ 3, and refractory status or intolerance of medical management were prospectively enrolled between June 2008 and August 2013...
January 10, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28070870/defining-the-risk-and-associated-morbidity-and-mortality-of-severe-respiratory-syncytial-virus-infection-among-infants-with-congenital-heart-disease
#9
REVIEW
Paul A Checchia, Bosco Paes, Louis Bont, Paolo Manzoni, Eric A F Simões, Brigitte Fauroux, Josep Figueras-Aloy, Xavier Carbonell-Estrany
INTRODUCTION: The REGAL (RSV Evidence-a Geographical Archive of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This fourth publication covers the risk and burden of RSV infection in infants with congenital heart disease (CHD). METHODS: A systematic review was undertaken for articles published between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials...
January 9, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28070763/uveitis-in-childhood-onset-systemic-lupus-erythematosus-patients-a-multicenter-survey
#10
Paola Pinheiro Kahwage, Mariana Paes Leme Ferriani, João M Furtado, Luciana Martins de Carvalho, Gecilmara Salviato Pileggi, Francisco Hugo Rodrigues Gomes, Maria Teresa Terreri, Claudia Saad Magalhães, Rosa Maria Rodrigues Pereira, Silvana Brasilia Sacchetti, Roberto Marini, Eloisa Bonfá, Clovis Artur Silva, Virgínia Paes Leme Ferriani
The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis were assessed for lupus clinical/laboratory features and treatments...
January 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28069643/gepotidacin-gsk2140944-in-vitro-activity-against-neisseria-gonorrhoeae-mic-mbc-kill-kinetics-checkerboard-pae-sme-tests
#11
D J Farrell, H S Sader, P R Rhomberg, N E Scangarella-Oman, R K Flamm
Gepotidacin, (formerly GSK2140944) is a novel, first in class, triazaacenaphthylene antibacterial, which inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated in vitro activity against Neisseria gonorrhoeae, including drug-resistant strains, and also target pathogens associated with other conventional and biothreat infections. Broth microdilution was used to evaluate the minimum inhibitory/bactericidal concentration (MIC/MBC) activity of gepotidacin and comparators against 25 N...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28057454/infiltrating-lipomatosis-of-the-face-case-series-and-literature-review
#12
Marianna Sampaio Serpa, Crispian Scully, Ana Paula Molina Vivas, Oslei Paes de Almeida, Felipe D'Almeida Costa, Fábio Abreu Alves
Infiltrating lipomatosis of the face is a rare disorder in which mature adipocytes infiltrate tissues, leading to facial asymmetry. We present three cases, emphasizing their clinical and imaging features. In two of our cases, typical clinical features of infiltrating lipomatosis of the face were observed, including enlargement of cheek and bones, as well as early tooth eruption. The other case stood out because of its uncommon clinical presentation: presenting with hemimacroglossia, ipsilateral submandibular gland enlargement, and papillomatosis on the dorsum of the tongue...
October 15, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28054898/pump-thrombosis-following-heartmate-ii-left-ventricular-assist-device-implantation-in-a-patient-with-aspirin-and-plavix-resistance
#13
Ali Ghodsizad, A Badiye, M Zeriouh, W Pae, M M Koerner, M Loebe
Despite advances in pump technology, thromboembolic events and pump thrombosis are potentially life-threatening complications in patients with continuous flow ventricular assist devices. Here we describe a patient with pump thrombosis following LVAD HeartMate II implantation presenting with Aspirin and Plavix resistance and signs of acute hemolysis as manifested by high LDH, changing pump power, pulse index and reduced pump flows.
14, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/28045920/alterations-in-evoked-otoacoustic-emissions-by-the-use-of-meglumine-antimoniate-in-american-tegumentary-leishmaniasis-patients
#14
Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
INTRODUCTION: Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28040333/signs-and-symptoms-of-rheumatic-diseases-as-first-manifestation-of-pediatric-cancer-diagnosis-and-prognosis-implications
#15
Mariana Bertoldi Fonseca, Francisco Hugo Rodrigues Gomes, Elvis Terci Valera, Gecilmara Salviato Pileggi, Paula Braga Gonfiantini, Marcela Braga Gonfiantini, Virgínia Paes Leme Ferriani, Luciana Martins de Carvalho
OBJECTIVE: To assess the prevalence and describe the clinical, laboratory and radiological findings, treatment and outcome of children with cancer initially referred to a tertiary outpatient pediatric rheumatology clinic. METHODS: Retrospective analysis of medical records from patients identified in a list of 250 new patients attending the tertiary Pediatric Rheumatology Clinic, Ribeirão Preto Medical School hospital, University of São Paulo, from July 2013 to July 2015, whose final diagnosis was cancer...
December 16, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28039590/ten-years-of-ipsc-clinical-potential-and-advances-in-vitro-hematopoietic-differentiation
#16
REVIEW
Bárbara Cristina Martins Fernandes Paes, Pablo Diego Moço, Cristiano Gonçalves Pereira, Geciane Silveira Porto, Elisa Maria de Sousa Russo, Luiza Cunha Junqueira Reis, Dimas Tadeu Covas, Virginia Picanço-Castro
Ten years have passed since the first publication announcing the generation of induced pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability seemed to be solved following this breakthrough. The development of iPSC technology allows advances in in vitro cell differentiation for cell therapy purpose and other clinical applications. This review provides a perspective on the iPSC potential for cell therapies, particularly for hematological applications. We discuss the advances in in vitro hematopoietic differentiation, the possibilities to employ iPSC in hematology studies, and their potential clinical application in hematologic diseases...
December 30, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28034640/oral-perineurioma-clinicopathologic-features-from-two-cases-and-review-of-literature
#17
Wagner Gomes da Silva, Marisol Martínez Martínez, Águida Maria Menezes Aguiar Miranda, Roberto Bastos Silva, Henrique Martins da Silveira, Oslei Paes de Almeida, Fábio Ramôa Pires
The present study reports two cases of oral perineuriomas, including a clinicopathologic review of the 39 published cases (17 intraneural and 22 extraneural perineuriomas) in the English language literature. In the first case, the tumor occurred in an 84-year-old male as a painless, asymptomatic, 20-mm submucosal nodule on the right lower mucobuccal fold near to the premolar area. In the second case, a 46-year-old female presented with a painless, 25-mm, slow-growing, fibrous, pedunculated nodule on the right buccal mucosa...
October 12, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28032133/a-systematic-review-of-prostatic-artery-embolization-in-the-treatment-of-symptomatic-benign-prostatic-hyperplasia
#18
Michelle Kuang, Anthony Vu, Sriharsha Athreya
PURPOSE: To summarize current evidence on outcomes and complications of prostatic artery embolization as a treatment for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS AND MATERIALS: A database search of MEDLINE, Embase, Web of Science, and Cochrane Library was performed for published literature up to August 2015 concerning PAE in the treatment of BPH. Inclusion and exclusion criteria were applied by two independent reviewers, and disagreements were resolved by consensus...
December 28, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28018874/hospital-admissions-for-lower-respiratory-tract-infections-among-infants-in-the-canadian-arctic-a-cohort-study
#19
Anna Banerji, Val Panzov, Michael Young, Joan Robinson, Bonita Lee, Theo Moraes, Muhammad Mamdani, B Louise Giles, Depeng Jiang, Danny Bisson, Marguerite Dennis, Johanne Morel, Judith Hall, Charles Hui, Bosco Paes, James B Mahony
BACKGROUND: It is unknown whether this burden of disease of lower respiratory tract infections is comparable across the Canadian Arctic. The objectives of this surveillance study were to compare the rates of hospital admission for lower respiratory tract infection and the severity of infection across Arctic Canada, and to describe the responsible viruses. METHODS: We performed a prospective multicentre surveillance study of infants less than 1 year of age admitted in 2009 with lower respiratory tract infection to all hospitals (5 regional, 4 tertiary) in the Northwest Territories, Nunavut and Nunavik to assess for regional differences...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28018235/modulation-of-muscle-fiber-compositions-in-response-to-hypoxia-via-pyruvate-dehydrogenase-kinase-1
#20
Daniel D Nguyen, Gyuyoup Kim, Eung-Kwon Pae
Muscle fiber-type changes in hypoxic conditions in accordance with pyruvate dehydrogenase kinase (Pdk)-1 and hypoxia inducible factor (Hif)-1α were investigated in rats. Hif-1α and its down-stream molecule Pdk-1 are well known for readily response to hypoxia. We questioned their roles in relation to changes in myosin heavy chain (MyHC) composition in skeletal muscles. We hypothesize that the level of Pdk-1 with respect to the level of Hif-1α determines MyHC composition of the muscle in rats in hypoxia. Young male rats were housed in a chamber maintained at 11...
2016: Frontiers in Physiology
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