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https://www.readbyqxmd.com/read/28746556/potential-intravenous-drug-interactions-in-intensive-care
#1
Maiara Benevides Moreira, Maria Gefé da Rosa Mesquita, Marluci Andrade Conceição Stipp, Graciele Oroski Paes
OBJECTIVE: To analyze potential intravenous drug interactions, and their level of severity associated with the administration of these drugs based on the prescriptions of an intensive care unit. METHOD: Quantitative study, with aretrospective exploratory design, and descriptive statistical analysis of the ICU prescriptions of a teaching hospital from March to June 2014. RESULTS: The sample consisted of 319 prescriptions and subsamples of 50 prescriptions...
July 20, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28743360/signs-and-symptoms-of-rheumatic-diseases-as-first-manifestation-of-pediatric-cancer-diagnosis-and-prognosis-implications
#2
Mariana Bertoldi Fonseca, Francisco Hugo Rodrigues Gomes, Elvis Terci Valera, Gecilmara Salviato Pileggi, Paula Braga Gonfiantini, Marcela Braga Gonfiantini, Virgínia Paes Leme Ferriani, Luciana Martins de Carvalho
OBJECTIVE: To assess the prevalence and describe the clinical, laboratory and radiological findings, treatment and outcome of children with cancer initially referred to a tertiary outpatient pediatric rheumatology clinic. METHODS: Retrospective analysis of medical records from patients identified in a list of 250 new patients attending the tertiary Pediatric Rheumatology Clinic, Ribeirão Preto Medical School hospital, University of São Paulo, from July 2013 to July 2015, whose final diagnosis was cancer...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28743001/gcl-and-cul3-control-the-switch-between-cell-lineages-by-mediating-localized-degradation-of-an-rtk
#3
Juhee Pae, Ryan M Cinalli, Antonio Marzio, Michele Pagano, Ruth Lehmann
The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by acting as a switch that turns off a somatic lineage pathway. GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(GCL)). We show that CRL3(GCL) promotes PGC fate by mediating degradation of Torso, a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742996/how-primordial-germ-cells-destroy-somatic-signals
#4
Lynn Cooley
The Germ Cell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embryos. Reporting in this issue of Developmental Cell, Pae et al. (2017) show that GCL blocks somatic cell fate by specifically destroying the Torso Receptor Tyrosine Kinase.
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28741807/il-17a-polymorphism-and-elevated-il-17a-serum-levels-are-associated-with-oral-lichen-planus
#5
Luiz Alcino Gueiros, Telma Arão, Thayse Souza, Camila Lins Vieira, Ricardo Santiago Gomez, Oslei Paes de Almeida, Giovani Lodi, Jair Carneiro Leão
OBJECTIVE: The aim of this study was to evaluate the association of IL-17A G197A polymorphism and serum levels with oral lichen planus susceptibility and clinical presentation. SUBJECTS AND METHODS: Eighty three individuals diagnosed with oral lichen planus (OLP) and ninety nine healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL-17A (G197A) genotyping. Blood samples of 42 OLP individuals and 23 healthy controls were collected for evaluation of IL-17A serum levels...
July 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28739796/multicenter-and-international-study-of-mic-mec-distributions-for-definition-of-epidemiological-cutoff-values-ecvs-for-species-of-sporothrix-identified-by-molecular-methods
#6
A Espinel-Ingroff, D P B Abreu, R Almeida-Paes, R S N Brilhante, A Chakrabarti, A Chowdhary, F Hagen, S Córdoba, G M Gonzalez, N P Govender, J Guarro, E M Johnson, S E Kidd, S A Pereira, A M Rodrigues, S Rozental, M W Szeszs, R Ballesté Alaniz, A Bonifaz, L X Bonfietti, L P Borba-Santos, J Capilla, A L Colombo, M Dolande, M G Isla, M S C Melhem, A C Mesa-Arango, M M E Oliveira, M M Panizo, Z Pires de Camargo, R M Zancope-Oliveira, J F Meis, J Turnidge
Clinical and Laboratory Standards Institute (CLSI) conditions for testing the susceptibilities of pathogenic Sporothrix species to antifungal agents are based on a collaborative study that evaluated five clinically relevant isolates of Sporothrix schenckii sensu lato and some antifungal agents. With the advent of molecular identification, there are two basic needs: to confirm the suitability of these testing conditions for all agents and Sporothrix species and to establish species-specific epidemiologic cutoff values (ECVs) or breakpoints (BPs) for these species...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28736794/tinea-capitis-by-microsporum-audouinii-case-reports-and-review-of-published-global-literature-2000-2016
#7
Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Rowena Alves Coelho, Anna Sales, Rodrigo Almeida-Paes
Tinea capitis caused by Microsporum audouinii is reported herein from two Brazilian schoolchildren, which are brothers. Arthroconidia were evidenced on direct examination of scalp hair, and a fungus of the genus Microsporum was isolated from cultures of each patient. The isolated fungi were classified as M. audouinii by visualization of species-specific structures, including: pectinate hyphae, chlamydospores, and fusiform macroconidia, sterile growth with characteristic brown pigment in rice grains, and through DNA sequencing of the internal transcriber spacer region...
July 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28734697/prognostic-significance-of-hmsh2-hmsh3-and-hmsh6-expression-in-ameloblastoma
#8
Gleyson Kleber do Amaral-Silva, Celeste Sánchez-Romero, Vivian Petersen Wagner, Manoela Domingues Martins, Hélder Antônio Rebelo Pontes, Eduardo Rodrigues Fregnani, Fernando Augusto Soares, Oslei Paes de Almeida, André Caroli Rocha, Alan Roger Santos-Silva, Felipe Paiva Fonseca, Pablo Agustin Vargas
OBJECTIVE: The aim of this study was to investigate hMutS proteins in developing human tooth, ameloblastomas, and ameloblastic carcinoma and to determine whether the expression of these proteins has any prognostic potential. STUDY DESIGN: Ten cases of developing human tooth, 39 ameloblastomas, and 2 ameloblastic carcinomas were used to determine the distribution of the proteins during the process of carcinogenesis. Simultaneously, another sample of 73 ameloblastomas was arranged in tissue microarray, and their clinical, microscopic, and radiographic features; treatment outcome; presence of BRAF-V600E mutation; and follow-up data were assessed to determine the prognostic relevance of the expression of hMutS (hMSH2, hMSH3, hMSH6) and Ki-67...
June 7, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28733230/clostridium-perfringens-and-c-%C3%A2-difficile-in-parvovirus-positive-dogs
#9
Rodrigo Otávio Silveira Silva, Fernanda Alves Dorella, Henrique Cesar Pereira Figueiredo, Érica Azevedo Costa, Vanessa Pelicia, Bruna Letícia Devidé Ribeiro, Marcio Garcia Ribeiro, Antonio Carlos Paes, Jane Megid, Francisco Carlos Faria Lobato
The aim of this study was to investigate Clostridium difficile and Clostridium perfringens in 82 diarrheic dogs positive for canine parvovirus type 2 (CPV). Enterotoxigenic C. perfringens type A was isolated from three (3.6%) dogs. One (1.2%) strain was also positive for NetE- and NetF-encoding genes, which are commonly associated with diarrhea in dogs. Toxigenic C. difficile was isolated from one animal (1.2%), which was also positive for A/B toxins. The present study identified C. difficile and C. perfringens infection in CPV-positive dogs...
July 19, 2017: Anaerobe
https://www.readbyqxmd.com/read/28731515/analysis-of-structure-function-network-decoupling-in-the-brain-systems-of-spastic-diplegic-cerebral-palsy
#10
Dongha Lee, Chongwon Pae, Jong Doo Lee, Eun Sook Park, Sung-Rae Cho, Min-Hee Um, Seung-Koo Lee, Maeng-Keun Oh, Hae-Jeong Park
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients...
July 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28724416/protective-effects-of-chebulic-acid-on-alveolar-epithelial-damage-induced-by-urban-particulate-matter
#11
Kyung-Won Lee, Mi-Hyun Nam, Hee-Ra Lee, Chung-Oui Hong, Kwang-Won Lee
BACKGROUND: Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction. To investigate the protective effect of CA against UPM-mediated collapse of the pulmonary alveolar epithelial (PAE) cell (NCI-H441), barrier integrity parameters, and their elements were evaluated in PAE. METHODS: CA was acquired from the laboratory previous reports...
July 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28724251/concurrent-exposures-to-nonylphenol-bisphenol-a-phthalates-and-organophosphate-pesticides-on-birth-outcomes-a-cohort-study-in-taipei-taiwan
#12
Yu-Fang Huang, Wen-Chi Pan, Yen-An Tsai, Chia-Huang Chang, Pei-Jung Chen, Yi-Shuan Shao, Ming-Song Tsai, Jia-Woei Hou, Chensheng Alex Lu, Mei-Lien Chen
Prenatal exposure to phenols, phthalates (PAEs), and organophosphate (OP) pesticides may increase the risk of abnormal birth outcomes. However, many previous studies have examined exposure to a limited number of chemical classes or exposure profiles limited to a specific stage of pregnancy. This study aims to characterize the concurrent exposure scenario throughout pregnancy by simultaneously monitoring internal doses of several endocrine-disrupting compounds (EDCs), including 2 phenols (nonylphenol (NP) and bisphenol A (BPA)), 9 PAEs, and 6 OP pesticide metabolites and to assess the relationships between concurrent exposure to EDCs and infant birth weight, length, and head and chest circumference...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724000/differences-and-inequalities-in-relation-to-access-to-renal-replacement-therapy-in-the-brics-countries
#13
Fábio Humberto Ribeiro Paes Ferraz, Cibele Isaac Saad Rodrigues, Giuseppe Cesare Gatto, Natan Monsores de Sá
End-stage renal disease (ESRD) is an important public health problem, especially in developing countries due to the high level of economic resources needed to maintain patients in the different programs that make up renal replacement therapy (RRT). To analyze the differences and inequalities involved in access to RRT in the BRICS countries (Brazil, Russian Federation, India, China and South Africa). This is an applied, descriptive, cross-sectional, quantitative and qualitative study, with documentary analysis and a literature review...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28721609/susceptibility-of-diaphorina-citri-hemiptera-liviidae-and-its-parasitoid-tamarixia-radiata-hymenoptera-eulophidae-to-entomopathogenic-fungi-under-laboratory-conditions
#14
K H Ibarra-Cortés, A W Guzmán-Franco, H González-Hernández, L D Ortega-Arenas, J A Villanueva-Jiménez, A Robles-Bermúdez
Diaphorina citri (Kuwayama) is a global pest of citrus that transmits the bacteria associated with the disease, Huanglongbing. Entomopathogenic fungi and the parasitoid Tamarixia radiata (Waterston) are important biological control agents of this pest and likely to interact in D. citri populations. As a basis for interaction studies, we determined the susceptibility of nymphs and adults of D. citri and adults of the parasitoid T. radiata to six fungal isolates from the species Beauveria bassiana s.l. (Bals...
July 18, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28720883/chronic-high-sodium-diet-intake-after-weaning-lead-to-neurogenic-hypertension-in-adult-wistar-rats
#15
Paula Magalhães Gomes, Renato Willian Martins Sá, Giovana Lopes Aguiar, Milede Hanner Saraiva Paes, Andréia Carvalho Alzamora, Wanderson Geraldo Lima, Lisandra Brandino de Oliveira, Sean David Stocker, Vagner Roberto Antunes, Leonardo M Cardoso
In this study, we investigated some mechanisms involved in sodium-dependent hypertension of rats exposed to chronic salt (NaCl) intake from weaning until adult age. Weaned male Wistar rats were placed under high (0.90% w/w, HS) or regular (0.27% w/w, Cont) sodium diets for 12 weeks. Water consumption, urine output and sodium excretion were higher in HS rats compared to control. Blood pressure (BP) was directly measured by the arterial catheter and found 13.8% higher in HS vs Cont rats. Ganglionic blockade with hexamethonium caused greater fall in the BP of HS rats (33%), and central antagonism of AT1 receptors (losartan) microinjected into the lateral ventricle reduced BP level of HS, but not of Cont group...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717651/comparison-of-nonspherical-polyvinyl-alcohol-particles-and-microspheres-for-prostatic-arterial-embolization-in-patients-with-benign-prostatic-hyperplasia
#16
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Sung Il Jung, Hae Jeong Jeon, Yong Soo Lho, Hyeong Gon Kim, Sung Hyun Paick, Hyoung Keun Park
PURPOSE: To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). METHODS: PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PVA particles (250-355 μm) in four patients and microspheres (300-500 μm) in five patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28717228/transformation-of-patchouli-alcohol-to-%C3%AE-patchoulene-by-gastric-juice-%C3%AE-patchoulene-is-more-effective-in-preventing-ethanol-induced-gastric-injury
#17
Yuhong Liu, Jiali Liang, Jiazhen Wu, Hanbin Chen, Zhenbiao Zhang, Hongmei Yang, Liping Chen, Haiming Chen, Ziren Su, Yucui Li
Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated that PA was converted to β-PAE by rat gastric juice...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717100/inhibitory-modulation-of-human-estrogen-receptor-%C3%AE-and-%C3%AE-activities-by-dicyclohexyl-phthalate-in-human-breast-cancer-cell-lines
#18
Hiroyuki Okazaki, Shuso Takeda, Saki Matsuo, Masaya Matsumoto, Erika Furuta, Eriko Kohro-Ikeda, Hironori Aramaki
Phthalate esters (PAEs) are man-made compounds that are used widely in industry, and the ubiquitous exposure of humans to PAEs has been reported. Although some PAEs have been suggested to function as xenoestrogens in in vitro systems, such as human estrogen receptors (ERs) expressed in Chinese hamster ovary (CHO)-K1 cells, few studies have attempted to elucidate whether PAEs affect human ERα/ERβ-mediated signaling in human breast cancer cells (i.e., combination between human ERs and human cells). Thus, further experiments are needed in order to clarify the activities of PAEs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28714235/tuberculosis-after-kidney-transplantation-is-associated-with-significantly-impaired-allograft-function
#19
Silvana Daher Costa, Tainá Veras de Sandes-Freitas, Camilla Neves Jacinto, Lorena Vasconcelos Mesquita Martiniano, Yago Sucupira Amaral, Fernando José Villar Nogueira Paes, Maria Luiza de Mattos Brito Oliveira Sales, Ronaldo de Matos Esmeraldo, Elizabeth de Francesco Daher
BACKGROUND: This study aimed to evaluate renal function before, during and after the course of tuberculosis (TB) disease in kidney transplant recipients; and assess the risk factors for non-recovery of baseline renal function. METHODS: We performed a retrospective, single-center cohort study, including all patients with confirmed or presumed TB diagnosis after kidney transplant (n=34, 2.1%). Renal function was assessed by serum creatinine (Cr) and glomerular filtration rate (GFR) adjusted for deaths and graft losses...
July 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28712773/spatial-distribution-and-seasonal-variation-of-phthalate-esters-in-the-jiulong-river-estuary-southeast-china
#20
Rongli Li, Jing Liang, Hualing Duan, Zhenbin Gong
The spatial distribution and seasonal variation of 16 phthalate esters (PAEs) in water, suspended particulate matter (SPM) and sediment were investigated in the Jiulong River estuary, Fujian, Southeast China. Of the 16 PAE congeners analyzed, only six PAEs, including dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DIBP), di-n-butyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DINP), were identified and quantified. The total concentrations of the six PAEs (∑6PAEs) detected for all seasons ranged from 3...
July 13, 2017: Marine Pollution Bulletin
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