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https://www.readbyqxmd.com/read/29775869/mathematics-intervention-for-children-with-fetal-alcohol-spectrum-disorder-a-replication-and-extension-of-the-math-interactive-learning-experience-mile-program
#1
Katrina Kully-Martens, Jacqueline Pei, Julie Kable, Claire D Coles, Gail Andrew, Carmen Rasmussen
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) experience deficits in behavior, cognition, and academic functioning resulting from prenatal alcohol exposure (PAE). Although receiving intervention for developmental disabilities is a strong protective factor against negative outcomes in FASD, intervention research in this population is in its infancy. AIMS: The purpose of this study was to replicate and extend a mathematics intervention, the Math Interactive Learning Experience (MILE) program, which was developed in the USA specifically for children with FASD...
May 15, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29770312/state-of-the-art-of-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia
#2
REVIEW
Mario Petrillo, Filippo Pesapane, Enrico Maria Fumarola, Ilaria Emili, Marzia Acquasanta, Francesca Patella, Salvatore Alessio Angileri, Umberto G Rossi, Igor Piacentini, Antonio Maria Granata, Anna Maria Ierardi, Gianpaolo Carrafiello
Prostatectomy via open surgery or transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH). Several patients present contraindication for standard approach, individuals older than 60 years with urinary tract infection, strictures, post-operative pain, incontinence or urinary retention, sexual dysfunction, and blood loss are not good candidates for surgery. Prostatic artery embolization (PAE) is emerging as a viable method for patients unsuitable for surgery...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29763639/complete-genome-sequence-of-gordonia-sp-yc-jh1-a-bacterium-efficiently-degrading-a-wide-range-of-phthalic-acid-esters
#3
Shuanghu Fan, Junhuan Wang, Kang Li, Ting Yang, Yang Jia, Baisuo Zhao, Yanchun Yan
Phthalic acid esters (PAEs) are a family of recalcitrant pollutants mainly used as plasticizer. The strain Gordonia sp.YC-JH1, isolated from petroleum-contaminated soil, is capable of efficiently degrading a wide range of PAEs. In order to pertinently investigate the genetic mechanisms of PAEs catabolism by strain YC-JH1, its complete genome sequencing has been performed by SMRT sequencing technology. The genome comprises a circular chromosome and a plasmid with a size of 4,101,557 bp and 91,767 bp respectively...
May 12, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29763474/early-prenatal-alcohol-exposure-alters-imprinted-gene-expression-in-placenta-and-embryo-in-a-mouse-model
#4
Heidi Marjonen, Mia Toivonen, Laura Lahti, Nina Kaminen-Ahola
Prenatal alcohol exposure (PAE) can harm the embryonic development and cause life-long consequences in offspring's health. To clarify the molecular mechanisms of PAE we have used a mouse model of early alcohol exposure, which is based on maternal ad libitum ingestion of 10% (v/v) ethanol for the first eight days of gestation (GD 0.5-8.5). Owing to the detected postnatal growth-restricted phenotype in the offspring of this mouse model and both prenatal and postnatal growth restriction in alcohol-exposed humans, we focused on imprinted genes Insulin-like growth factor 2 (Igf2), H19, Small Nuclear Ribonucleoprotein Polypeptide N (Snrpn) and Paternally expressed gene 3 (Peg3), which all are known to be involved in embryonic and placental growth and development...
2018: PloS One
https://www.readbyqxmd.com/read/29757760/cannula-tip-with-integrated-volume-sensor-for-rotary-blood-pump-control-early-stage-development
#5
Joshua Cysyk, Ray Newswanger, Eric Popjes, Walter Pae, Choon-Sik Jhun, Jenelle Izer, William Weiss, Gerson Rosenberg
The lack of direct measurement of left ventricular unloading is a significant impediment to the development of an automatic speed control system for continuous-flow left ventricular assist devices (cf-LVADs). We have developed an inlet cannula tip for cf-LVADs with integrated electrodes for volume sensing based on conductance. Four platinum-iridium ring electrodes were installed into grooves on a cannula body constructed from polyetheretherketone (PEEK). A sinusoidal current excitation waveform (250 μA pk-pk, 50 kHz) was applied across one pair of electrodes, and the conductance-dependent voltage was sensed across the second pair of electrodes...
May 10, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29754483/distribution-of-phthalate-metabolites-between-paired-maternal-fetal-samples
#6
Xiaoying Li, Hongwen Sun, Yiming Yao, Zhen Zhao, Xiaolei Qin, Yishuang Duan, Lei Wang
Phthalic acid esters (PAEs) are readily metabolized to phthalate metabolites (mPAEs) in the human body. The occurrence of mPAEs in adult human samples is well documented; however, the maternal-fetal transmission of mPAEs has seldom been studied. In this study, 78 paired maternal-fetal samples, including maternal urine (MU), maternal serum (MS), cord serum (CS), and amniotic fluid (AF), were collected from pregnant women in Tianjin, China. Seven mPAEs were detected in MS, CS and AF, whereas all 11 investigated mPAEs were found in MU...
May 14, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29753697/giant-dentinogenic-ghost-cell-tumor-a-case-report
#7
Ciro Dantas Soares, Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida
Dentinogenic ghost cell tumor (DGCT), a rare, benign odontogenic tumor with aggressive behavior, causes bone destruction and cortical expansion. We report here a case of DGCT in a 38-year-old male, presenting with enormous extraoral protrusion, which radiographically was predominantly radiolucent with radiopaque areas. Microscopically, it was observed to be a solid ameloblastomatous proliferation with pseudoglandular structures associated with clusters of ghost cells. Abundant dentinoid material adjacent to the epithelial sheets containing entrapped epithelial tumor cells was also evident...
April 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29752843/propofol-anesthesia-exposure-and-nonaversive-memory-retrieval-and-the-expression-of-molecules-involved-in-memory-process-in-the-dorsal-hippocampus-in-peripubertal-rats
#8
Željko Pavković, Desanka Milanović, Sabera Ruždijić, Selma Kanazir, Vesna Pešić
BACKGROUND: The effects of anesthetic drugs on postoperative cognitive function in children are not well defined and have not been experimentally addressed. AIMS: The present study aimed to examine the influence of propofol anesthesia exposure on nonaversive hippocampus-dependent learning and biochemical changes involved in memory process in the dorsal hippocampus, in peripubertal rats as the rodent model of periadolescence. METHODS: The intersession spatial habituation and the novel object recognition tasks were used to assess spatial and nonspatial, nonaversive hippocampus-dependent learning...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29752646/mri-features-after-prostatic-artery-embolization-for-the-treatment-of-medium-and-large-volume-benign-hyperplasia
#9
Hongtao Zhang, Yanguang Shen, Jingjing Pan, Haiyi Wang, Yan Zhong, Yingwei Wang, Huiyi Ye
PURPOSE: To assess magnetic resonance imaging (MRI) features after prostatic artery embolization (PAE) for the treatment of medium- and large-volume benign prostatic hyperplasia and to correlate prostate volume with clinical indexes. METHODS: We retrospectively evaluated 28 patients who underwent PAE. MRI examinations of the prostate were performed to evaluate signal intensity changes and the characteristics of infarcted areas. Prostate volume and the apparent diffusion coefficient (ADC) were measured at an average of 10 days post-PAE and at 1, 3, 6, and 12 months post-PAE...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29751654/biodegradation-of-di-2-ethylhexyl-phthalate-by-rhodococcus-ruber-yc-yt1-in-contaminated-water-and-soil
#10
Ting Yang, Lei Ren, Yang Jia, Shuanghu Fan, Junhuan Wang, Jiayi Wang, Ruth Nahurira, Haisheng Wang, Yanchun Yan
Di-(2-ethylehxyl) phthalate (DEHP) is one of the most broadly representative phthalic acid esters (PAEs) used as a plasticizer in polyvinyl chloride (PVC) production, and is considered to be an endocrine-disrupting chemical. DEHP and its monoester metabolites are responsible for adverse effects on human health. An efficient DEHP-degrading bacterial strain Rhodococcus ruber YC-YT1, with super salt tolerance (0⁻12% NaCl), is the first DEHP-degrader isolated from marine plastic debris found in coastal saline seawater...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29748753/electrospun-poly-%C3%AE%C2%B5-caprolactone-matrices-containing-silver-sulfadiazine-complexed-with-%C3%AE-cyclodextrin-as-a-new-pharmaceutical-dosage-form-to-wound-healing-preliminary-physicochemical-and-biological-evaluation
#11
Sarah Oliveira Lamas Souza, Monique Alvarenga Pinto Cotrim, Rodrigo Lambert Oréfice, Suzana Gonçalves Carvalho, Jessyca Aparecida Paes Dutra, Francisco de Paula Careta, Juliana Alves Resende, Janaina Cecília Oliveira Villanova
Cooperation between researchers in the areas of medical, pharmaceutical and materials science has facilitated the development of pharmaceutical dosage forms that elicit therapeutic effects and protective action with a single product. In addition to optimizing pharmacologic action, such dosage forms provide greater patient comfort and increase success and treatment compliance. In the present work, we prepared semipermeable bioactive electrospun fibers for use as wound dressings containing silver sulfadiazine complexed with β-cyclodextrin in a poly(Ɛ-caprolactone) nanofiber matrix aiming to reduce the direct contact between silver and skin and to modulate the drug release...
May 10, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29747108/distribution-and-ecotoxicological-state-of-phthalate-esters-in-the-sea-surface-microlayer-seawater-and-sediment-of-the-bohai-sea-and-the-yellow-sea
#12
Ze-Ming Zhang, Hong-Hai Zhang, Ya-Wen Zou, Gui-Peng Yang
The spatial distribution, chemical composition and ecological risk of 16 phthalate esters (PAEs) were investigated in the sea-surface microlayer (SML), seawater and sediment samples of the Bohai Sea (BS) and the Yellow Sea (YS). The concentration levels of the ΣPAEs spanned a range of 449-13441 ng L-1 in the SML, 453-5108 ng L-1 in seawater, and 1.24-15.8 mg kg-1 in the sediment samples, respectively, with diisobutyl phthalate (DiBP), di-n-butyl phthalate (DBP) and di-ethylhexyl phthalate (DEHP) as the dominant PAEs in both the water and sediment samples...
May 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29741113/chemical-characterization-and-bioherbicidal-potential-of-the-essential-oil-from-the-leaves-of-unonopsis-guatterioides-a-dc-r-e-fr-annonaceae
#13
Nídia Cristiane Yoshida, Francis Paes Saffran, William Gustavo Lima, Talita Vilalva Freire, João Máximo de Siqueira, Walmir Silva Garcez
The chemical composition and the phytotoxicity potential of the essential oil from leaves of Unonopsis guatterioides (A.DC.) R.E.Fr. (Annonaceae) was investigated. Gas chromatography/mass spectrometry analyses revealed 16 constituents representing 99.50% of the total essential oil, composed mainly of sesquiterpenes. α-copaene, bicyclogermacrene and trans-caryophyllene were the major components (15.7% each), followed by α-humullene, allo-aromadendrene and (+)-spathulenol (9.0, 8.4 and 7.3%, respectively). The essential oil inhibited seed germination and growth in both monocotyledon (Allium cepa) and dicotyledon (Lactuca sativa) models, pointing to a promising application of this oil obtained from the leaves of U...
May 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29732358/anatomical-popliteal-artery-entrapment-syndrome
#14
Yong Jae Kwon, Tae-Won Kwon, Jun Gyo Gwon, Yong-Pil Cho, Seung-Jun Hwang, Ki-Young Go
Purpose: The aim of this study was to analyze anatomical popliteal artery entrapment syndrome (PAES) and to individualize the treatment of this condition according to the anatomical status of the artery and the adjacent structure. Methods: A total of 35 anatomical PAES legs in 23 consecutive patients treated within the Asan Medical Center, Seoul, Korea between 1995 and 2011 were analyzed retrospectively. Anatomical PAES was diagnosed by MRI and/or CT scans of the knee joint, and CT or conventional transfemoral arteriography of the lower extremities...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29730677/early-post-interventional-sonographic-evaluation-of-prostatic-artery-embolization-a-promising-role-for-contrast-enhanced-ultrasonography-ceus
#15
Hippocrates Moschouris, Konstantinos Stamatiou, Mariana Kalokairinou Motogna, Spyros Vrakas, Michail Kiltenis, Konstantinos Kladis-Kalentzis, Avraam Tsavdaroglou, Nikolaos Papadogeorgopoulos, Kyriaki Marmaridou, Katerina Malagari
AIMS: To assess the feasibility, findings and potential value of early post-interventional, contrast-enhanced ultrasonographic (CEUS) study of prostate artery embolization (PAE). MATERIAL AND METHODS: Fourteen patients treated with PAE for symptomatic benign prostatic hyperplasia were prospectively included in the study. Sonographic evaluation of the prostate included: 1) baseline transabdominal and transrectal CEUS (ta-CEUS and tr-CEUS, respectively) 1-3 days prior to PAE; 2) early post PAE CEUS, with ta-CEUS immediately post PAE and tr-CEUS 3 days post PAE; and 3) follow-up with ta-CEUS and tr-CEUS 3 months post PAE...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29728782/respiratory-syncytial-virus-prophylaxis-in-cystic-fibrosis-the-canadian-registry-of-palivizumab-data-2005-2016
#16
Ian Mitchell, S K Wong, B Paes, M Ruff, C Bjornson, A Li, K L Lanctôt
Respiratory syncytial virus (RSV) may cause severe illness in cystic fibrosis (CF) children, but recommendations vary on prophylaxis. CARESS is a prospective registry of children who received palivizumab in 32 Canadian sites from 2005 to 2016. Demographic data were collected at enrollment and respiratory illness-related events recorded monthly. We reviewed respiratory illness hospitalization (RIH) and RSV hospitalization (RSVH) in CF children aged < 24 months versus those prophylaxed for standard indications (SI; prematurity, chronic lung disease [CLD] and congenital heart disease [CHD]), and complex medical disorders (CM)...
May 4, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29727973/extraneous-dissolved-organic-matter-enhanced-adsorption-of-dibutyl-phthalate-in-soils-insights-from-kinetics-and-isotherms
#17
Wei Wu, Hongjie Sheng, Chenggang Gu, Yang Song, Sabine Willbold, Yan Qiao, Guangxia Liu, Wei Zhao, Yu Wang, Xin Jiang, Fang Wang
The widespread use of plastic film, especially in agricultural practices, has resulted in phthalic acid esters (PAEs) pollution, which poses risks for greenhouse soils. Application of composted manure is a common agricultural practice that adds extraneous dissolved organic matter (DOM) to the soil, however, the effect of extraneous DOM on the behavior of PAEs in agricultural soil is not clear. Dibutyl phthalate (DBP) was used as a model compound to investigate the effect and mechanism of extraneous DOM on the adsorption kinetics and isotherms of PAEs in two types of soils, through batch experiments and characterization of extraneous DOM and soils using fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR)...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29718569/grp78-targeted-in-silico-virtual-screening-of-novel-anticancer-agents
#18
Ambily Nath Indu Viswanath, Ji Woong Lim, Seon Hee Seo, Jae Yeol Lee, Sang Min Lim, Ae Nim Pae
Overexpression of GRP78 in a variety of cancers such as glioblastoma, leukaemia, lung, prostate, breast, gastric, and colon makes it a prime target for anticancer drug development. Present study reports GRP78-based design of novel anticancer agents using in silico methods. As a first step towards the work, the interactions between GRP78 and 15 known ligands were modeled by docking simulation. The docked complex, GRP78-13, superior to other compounds with respect to its experimental activity and energy descriptors, was deduced into a structure-based pharmacophore...
May 2, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29717158/genomic-analysis-and-immune-response-in-a-murine-mastitis-model-of-vb_ecom-ufv13-a-potential-biocontrol-agent-for-use-in-dairy-cows
#19
Vinícius da Silva Duarte, Roberto Sousa Dias, Andrew M Kropinski, Stefano Campanaro, Laura Treu, Carolina Siqueira, Marcella Silva Vieira, Isabela da Silva Paes, Gabriele Rocha Santana, Franciele Martins, Josicelli Souza Crispim, André da Silva Xavier, Camila Geovana Ferro, Pedro M P Vidigal, Cynthia Canêdo da Silva, Sérgio Oliveira de Paula
Bovine mastitis remains the main cause of economic losses for dairy farmers. Mammary pathogenic Escherichia coli (MPEC) is related to an acute mastitis and its treatment is still based on the use of antibiotics. In the era of antimicrobial resistance (AMR), bacterial viruses (bacteriophages) present as an efficient treatment or prophylactic option. However, this makes it essential that its genetic structure, stability and interaction with the host immune system be thoroughly characterized. The present study analyzed a novel, broad host-range anti-mastitis agent, the T4virus vB_EcoM-UFV13 in genomic terms, and its activity against a MPEC strain in an experimental E...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29716536/dopamine-d2-receptor-gene-polymorphisms-and-externalizing-behaviors-in-children-and-adolescents
#20
Osmar Henrique Della Torre, Lúcia Arisaka Paes, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Eloisa Helena Rubello Valler Celeri, Paulo Dalgalarrondo, Gil Guerra-Júnior, Amilton Dos Santos-Júnior
BACKGROUND: Dopamine is involved in several cerebral physiological processes, and single nucleotide polymorphisms (SNP) in the dopamine D2 receptor gene (DRD2) have been associated with numerous neurological and mental disorders, including those involving alterations in cognitive and emotional processes. METHODS: The aim of this study was to evaluate the association between the SNPs c.957C > T (rs6277) and c.-585A > G (rs1799978) in the DRD2 gene and behavioral characteristics of children and adolescents based on an inventory of the Child Behavior Checklist (CBCL)...
May 2, 2018: BMC Medical Genetics
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