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https://www.readbyqxmd.com/read/29155170/bench-to-bedside-translation-of-dendrimers-reality-or-utopia-a-concise-analysis
#1
Serge Mignani, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral
Nanomedicine, which is an application of nanotechnologies in healthcare is developed to improve the treatments and lives of patients suffering from a range of disorders and to increase the successes of drug candidates. Within the nanotechnology universe, the remarkable unique and tunable properties of dendrimers have made them promising tools for diverse biomedical applications such as drug delivery, gene therapy and diagnostic. Up-to-date, very few dendrimers has yet gained regulatory approval for systemic administration, why? In this critical review, we briefly focus on the list of desired basic dendrimer requirements for decision-making purpose by the scientists (go/no-go decision), in early development stages, to become clinical candidates, and to move towards Investigational New Drugs (IND) application submission...
November 16, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29154693/epidemiology-of-injury-due-to-race-day-jockey-falls-in-professional-flat-and-jump-horse-racing-in-ireland-2011-2015
#2
Siobhan O'Connor, Giles Warrington, Adrian McGoldrick, SarahJane Cullen
CONTEXT:   Professional horse racing is considered a high-risk sport, yet the last analysis of fall and injury incidence in this sport in Ireland was completed between 1999 and 2006. OBJECTIVE:   To provide an updated analysis of the fall and injury incidence in professional flat and jump horse racing in Ireland from 2011 through 2015, compare it with the previous analysis, and detail the specific types and locations of injuries. DESIGN:   Descriptive epidemiology study...
November 20, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29154692/landing-kinematics-and-kinetics-at-the-knee-during-different-landing-tasks
#3
Nicholas R Heebner, Deirdre M Rafferty, Meleesa F Wohleber, Andrew J Simonson, Mita Lovalekar, Andrew Reinert, Timothy C Sell
CONTEXT:   Several tasks have been used to examine landing biomechanics for evaluation and rehabilitation, especially as related to anterior cruciate ligament injuries. However, comparing results among studies in which different tasks were used can be difficult, and it is unclear which task may be most appropriate. OBJECTIVE:   To compare lower extremity biomechanics across 5 commonly used landing tasks. DESIGN:   Descriptive laboratory study...
November 20, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29153402/phylogenetics-and-phylogenomics-of-rust-fungi
#4
M Catherine Aime, Alistair R McTaggart, Stephen J Mondo, Sébastien Duplessis
Rust fungi (Pucciniales) are the most speciose and the most complex group of plant pathogens. Historically, rust taxonomy was largely influenced by host and phenotypic characters, which are potentially plastic. Molecular systematic studies suggest that the extant diversity of this group was largely shaped by host jumps and subsequent shifts. However, it has been challenging to reconstruct the evolutionary history for the order, especially at deeper (family-level) nodes. Phylogenomics offer a potentially powerful tool to reconstruct the Pucciniales tree of life, although researchers working at this vanguard still face unprecedented challenges working with nonculturable organisms that possess some of the largest and most repetitive genomes now known in kingdom fungi...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29152417/assessing-mongolian-gerbil-emotional-behavior-effects-of-two-shock-intensities-and-response-independent-shocks-during-an-extended-inhibitory-avoidance-task
#5
Camilo Hurtado-Parrado, Camilo González-León, Mónica A Arias-Higuera, Angelo Cardona, Lucia G Medina, Laura García-Muñoz, Christian Sánchez, Julián Cifuentes, Juan Carlos Forigua, Andrea Ortiz, Cesar A Acevedo-Triana, Javier L Rico
Despite step-down inhibitory avoidance procedures that have been widely implemented in rats and mice to study learning and emotion phenomena, performance of other species in these tasks has received less attention. The case of the Mongolian gerbil is of relevance considering the discrepancies in the parameters of the step-down protocols implemented, especially the wide range of foot-shock intensities (i.e., 0.4-4.0 mA), and the lack of information on long-term performance, extinction effects, and behavioral patterning during these tasks...
2017: PeerJ
https://www.readbyqxmd.com/read/29152283/the-extra-anatomical-jump-graft-reconstruction-of-the-right-hepatic-artery-after-resection-of-a-biliary-tract-malignancy-with-a-common-hepatic-artery-aneurysm-a-case-report
#6
Yuta Kakizaki, Shigehito Miyagi, Yasuyuki Hara, Atsushi Fujio, Koji Miyazawa, Kai Maida, Toshiaki Kashiwadate, Kazuaki Tokodai, Chikashi Nakanishi, Takashi Kamei, Michiaki Unno
Performing resection of a biliary tract malignancy with a hepatic artery aneurysm is very challenging. Resection of the extrahepatic bile duct and extra-anatomical reconstruction can be successfully performed using free radial artery autografts from the aorta to the right hepatic artery. Hepatic artery thrombosis can be prevented with intimal preservation.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29151096/jumping-frenchmen-miryachit-and-latah-culture-specific-hyperstartle-plus-syndromes
#7
Douglas J Lanska
In the late 19th century, jumping (French Canadians in Maine, USA), miryachit (Siberia), and latah (Southeast Asia) were among a group of similar disorders described around the world, each of which manifests as an exaggerated startle response with additional late-response features that were felt by some to overlap with hysteria or tics. The later features following the exaggerated startle reaction variably include mimesis (e.g., echopraxia, echolalia) and automatic obedience. These reaction patterns tended to persist indefinitely in affected individuals...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29150657/specific-heat-electrical-resistivity-and-electronic-band-structure-properties-of-noncentrosymmetric-th7fe3-superconductor
#8
V H Tran, M Sahakyan
Noncentrosymmetric superconductor Th7Fe3 has been investigated by means of specific heat, electrical resisitivity measurements and electronic properties calculations. Sudden drop in the resistivity at 2.05 ± 0.15 K and specific heat jump at 1.98 ± 0.02 K are observed, rendering the superconducting transition. A model of two BCS-type gaps appears to describe the zero-magnetic-field specific heat better than those based on the isotropic BCS theory or anisotropic functions. A positive curvature of the upper critical field H c2(T c) and nonlinear field dependence of the Sommerfeld coefficient at 0...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150613/a-study-of-the-ground-attachment-process-in-natural-lightning-with-emphasis-on-its-breakthrough-phase
#9
M D Tran, V A Rakov
Synchronized high-speed (124 or 210 kiloframes per second) video images and wideband electromagnetic field records of the attachment process were obtained for 4 negative strokes in natural lightning at the Lightning Observatory in Gainesville, Florida. The majority of imaged upward connecting leaders (UCLs) and upward unconnected leaders, inferred to be mostly initiated from trees, exhibited a pulsating behavior (brightening/fading cycles). UCLs, whose maximum extent ranged from 11 to 25 m, propagated in virgin air at speeds ranging from 1...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29147670/isokinetic-extension-strength-is-associated-with-single-leg-vertical-jump-height
#10
Felix Fischer, Cornelia Blank, Tobias Dünnwald, Peter Gföller, Elmar Herbst, Christian Hoser, Christian Fink
Background: Isokinetic strength testing is an important tool in the evaluation of the physical capacities of athletes as well as for decision making regarding return to sports after anterior cruciate ligament (ACL) reconstruction in both athletes and the lay population. However, isokinetic testing is time consuming and requires special testing equipment. Hypothesis: A single-jump test, regardless of leg dominance, may provide information regarding knee extension strength through the use of correlation analysis of jump height and peak torque of isokinetic muscle strength...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29143442/development-of-biomimetic-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-via-a-novel-electrospinning-approach
#11
Emily Yu, Hao-Yang Mi, Jue Zhang, James A Thomson, Lih-Sheng Turng
A new electrospinning approach for fabricating vascular grafts with a layered, circumferentially aligned, and micro-wavy fibrous structure similar to natural elastic tissues has been developed. The customized electrospinning collector was able to generate wavy fibers using the dynamic "jump rope" collecting process, which also solved the sample removal problem for mandrel-type collectors. In this study, natural silk fibroin and synthetic thermoplastic polyurethane (TPU) were combined at different weight ratios to produce hybrid small-diameter vascular grafts...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29142017/modelling-the-effects-of-phylogeny-and-body-size-on-within-host-pathogen-replication-and-immune-response
#12
Soumya Banerjee, Alan S Perelson, Melanie Moses
Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how disease progression and immune response depend on mass and host phylogeny...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29141877/giving-invertebrates-an-eye-exam-an-ophthalmoscope-that-utilizes-the-autofluorescence-of-photoreceptors
#13
Annette Stowasser, Madeline Owens, Elke K Buschbeck
One of the most important functional features of eyes is focusing light, as both nearsightedness and farsightedness have major functional implications. Accordingly, refractive errors are frequently assessed in vertebrates, but not in the very small invertebrate eyes. We describe a micro-ophthalmoscope that takes advantage of autofluorescent properties of invertebrate photoreceptors and test the device on the relatively well-understood eyes of jumping spiders and flies. In each case, our measurements confirmed previous findings with a greater degree of accuracy...
November 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29141589/reconstructing-cancer-karyotypes-from-short-read-data-the-half-empty-and-half-full-glass
#14
Rami Eitan, Ron Shamir
BACKGROUND: During cancer progression genomes undergo point mutations as well as larger segmental changes. The latter include, among others, segmental deletions duplications, translocations and inversions.The result is a highly complex, patient-specific cancer karyotype. Using high-throughput technologies of deep sequencing and microarrays it is possible to interrogate a cancer genome and produce chromosomal copy number profiles and a list of breakpoints ("jumps") relative to the normal genome...
November 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29141434/dynamic-heterogeneity-in-an-orientational-glass
#15
Nirvana B Caballero, Mariano Zuriaga, Josep Lluís Tamarit, Pablo Serra
The family of compounds CBrnCl4-n has been proven helpful in unraveling microscopic mechanisms responsible for glassy behavior. Some of the family members show translational ordered phases with minimal disorder which appears to reveal glassy features, thus deserving special attention in the search for universal glass anomalies. In this work, we studied CBrCl3 dynamics by performing extensive molecular dynamics simulations. Molecules of this compound perform reorientational discrete jumps, where the atoms exchange equivalent positions among each other revealing a cage-orientational jump motion fully comparable to the cage-rototranslational jump motion in supercooled liquids...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29140914/sequencing-effects-of-neuromuscular-training-on-physical-fitness-in-youth-elite-tennis-players
#16
Jaime Fernandez-Fernandez, Urs Granacher, David Sanz-Rivas, Jose Manuel Sarabia Marín, Jose Luis Hernandez-Davo, Manuel Moya
Fernandez-Fernandez, J, Granacher, U, Sanz-Rivas, D, Sarabia Marín, JM, Hernandez-Davo, JL, and Moya, M. Sequencing effects of neuromuscular training on physical fitness in youth elite tennis players. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to analyze the effects of a 5-week neuromuscular training (NMT) implemented before or after a tennis session in prepubertal players on selected components of physical fitness. Sixteen elite and well-trained tennis players with a mean age of 12...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140912/reliable-testing-battery-for-assessing-physical-qualities-of-elite-academy-rugby-league-players
#17
Nick Dobbin, Richard Hunwicks, Jamie Highton, Craig Twist
Dobbin, N, Hunwicks, R, Highton, J, and Twist, C. Reliable testing battery for assessing physical qualities of elite academy rugby league players. J Strength Cond Res XX(X): 000-000, 2017-This study assessed the interday reliability of a testing battery for the assessment of physical qualities of rugby league players. Fifty players (age 17.1 ± 1.1 years; stature 181.3 ± 6.3 cm; and body mass 89.0 ± 11.6 kg) from 3 Super League academies participated in this study. Tests of countermovement jump performance, 10- and 20-m sprint performance, change of direction, medicine ball throw, and a modified Yo-Yo Intermittent Recovery Test Level 1 (prone Yo-Yo IR1) were completed on 3 separate occasions...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29137450/moving-forward-with-actionable-therapeutic-targets-and-opportunities-in-endometrial-cancer-nci-clinical-trials-planning-meeting-report-on-identifying-key-genes-and-molecular-pathways-for-targeted-endometrial-cancer-trials
#18
REVIEW
Helen J MacKay, Douglas A Levine, Victoria L Bae-Jump, Daphne W Bell, Jessica N McAlpine, Alessandro Santin, Gini F Fleming, David G Mutch, Kenneth P Nephew, Nicolas Wentzensen, Paul J Goodfellow, Oliver Dorigo, Hans W Nijman, Russell Broaddus, Elise C Kohn
The incidence and mortality rates from endometrial cancer are increasing. There have been no new drugs approved for the treatment of endometrial cancer in decades. The National Cancer Institute, Gynecologic Cancer Steering Committee identified the integration of molecular and/or histologic stratification into endometrial cancer management as a top strategic priority. Based on this, they convened a group of experts to review the molecular data in this disease. Here we report on the actionable opportunities and therapeutic directions identified for incorporation into future clinical trials...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136379/rotational-diffusion-propagator-of-the-intramolecular-proton-proton-vector-in-liquid-water-a-molecular-dynamics-study
#19
Wisman Acharige Monika Madhavi, M S Samantha Weerasinghe, Konstantin I Momot
Rotational motion of water molecules plays the dominant role in determining NMR spin relaxation properties of liquid water and many biological tissues. The traditional theory of NMR spin relaxation predominantly uses the assumption that the reorientational dynamics of water molecules is described by a continuous-time rotational-diffusion random walk with a single rotational diffusion coefficient. However, recent experimental and theoretical studies have demonstrated that water reorientation occurs via large, discrete angle jumps superimposed on a continuous-time rotational diffusion process...
November 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29134008/a-genome-wide-phylogeny-of-jumping-spiders-araneae-salticidae-using-anchored-hybrid-enrichment
#20
Wayne P Maddison, Samuel C Evans, Chris A Hamilton, Jason E Bond, Alan R Lemmon, Emily Moriarty Lemmon
We present the first genome-wide molecular phylogeny of jumping spiders (Araneae: Salticidae), inferred from Anchored Hybrid Enrichment (AHE) sequence data. From 12 outgroups plus 34 salticid taxa representing all but one subfamily and most major groups recognized in previous work, we obtained 447 loci totalling 96,946 aligned nucleotide sites. Our analyses using concatenated likelihood, parsimony, and coalescent methods (ASTRAL and SVDQuartets) strongly confirm most previous results, resolving as monophyletic the Spartaeinae, Salticinae (with the hisponines sister), Salticoida, Amycoida, Saltafresia, and Simonida...
2017: ZooKeys
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