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https://www.readbyqxmd.com/read/29790347/hydrophobic-collapse-of-ubiquitin-generates-rapid-protein-water-motions
#1
Hanna Wirtz, Sarah Schaefer, Claudius Hoberg, Korey M Reid, David M Leitner, Martina Havenith
We report time resolved measurements of the coupled protein-water modes of solvated ubiquitin during protein folding. Kinetic terahertz absorption (KITA) spectroscopy serves as a label-free technique to monitor large-scale conformational changes and folding of proteins subsequent to a sudden T-jump. Our KITA measurements reveal a significant change in the coupled ubiquitin-solvent dynamics even in the initial phase of hydrophobic collapse. Complementary equilibrium experiments and molecular simulations of ubiquitin solutions were carried out to clarify non-equilibrium contributions and reveal the molecular picture upon structural change, respectively...
May 23, 2018: Biochemistry
https://www.readbyqxmd.com/read/29789267/the-effect-of-lower-limb-occlusion-on-recovery-following-sprint-exercise-in-academy-rugby-players
#2
N Williams, M Russell, C J Cook, L P Kilduff
OBJECTIVES: The effects of vascular occlusion on recovery of physiological and neuromuscular markers over 24h, and hormonal reactivity to subsequent exercise were investigated. DESIGN: Counterbalanced, randomised, crossover. METHODS: Academy rugby players (n=24) completed six 50-m sprints (5-min inter-set recovery) before occlusion cuff application (thighs) and intermittent inflation to 171-266mmHg (Recovery) or 15mmHg (Con) for 12-min (two sets, 3-min repetitions, 3-min non-occluded reperfusion)...
March 3, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29788859/female-judo-athletes-physical-test-performances-are-unrelated-to-technical-tactical-competition-skills
#3
Rafael L Kons, Juliano Dal Pupo, Jonathan Ache-Dias, Daniele Detanico
This study analyzed the relationship between generic and judo-specific physical test performances and technical-tactical competition performances among 19 female judo athletes. Participant data were gathered in two stages: (a) physical tests-countermovement jump (CMJ), handgrip strength, Special Judo Fitness Test and Judogi Grip Strength Test; and (b) match performances recorded for technical-tactical analysis. Pearson's linear correlation and multiple linear regression analysis showed no significant correlations between any technical-tactical parameter and judo-specific physical tests...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29788831/lumbosacral-transitional-vertebrae-in-cats-and-its-relationship-to-lumbosacral-vertebral-canal-stenosis
#4
Georgina Harris, Jessica Ball, Steven De Decker
Objectives Although a clear relationship has been demonstrated between the presence of lumbosacral transitional vertebrae and the development of lumbosacral stenosis in dogs, this relationship has not been evaluated in cats. The aim of this study was to investigate the relationship between the presence of lumbosacral transitional vertebrae and lumbosacral stenosis in cats. Methods The medical records and diagnostic imaging studies of 13 cats diagnosed with lumbosacral stenosis were retrospectively reviewed for lumbosacral abnormalities and compared with findings of 405 cats that underwent CT for reasons unrelated to spinal disease...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29788745/obesity-and-physical-fitness-indices-of-children-aged-5-12-years-living-on-remote-and-isolated-islands
#5
Panagiotis Koulouvaris, Charilaos Tsolakis, Yiannis E Tsekouras, Olyvia Donti, Panagiotis J Papagellopoulos
INTRODUCTION: Obesity has become one of the major health risks in childhood, significantly affecting children's health and physical fitness. Although the marked increase of obesity in urban areas is well established, evidence is limited in remote and isolated areas with adverse socioeconomic features. The aim of this study was to examine the prevalence of obesity and its association with physical performance indices in young school-aged children living in 18 remote and isolated Greek islands...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29788398/inferring-diversification-rate-variation-from-phylogenies-with-fossils
#6
Jonathan S Mitchell, Rampal S Etienne, Daniel L Rabosky
Time-calibrated phylogenies of living species have been widely used to study the tempo and mode of species diversification. However, it is increasingly clear that inferences about species diversification - extinction rates in particular - can be unreliable in the absence of paleontological data. We introduce a general framework based on the fossilized birth-death process for studying speciation-extinction dynamics on phylogenies of extant and extinct species. The model assumes that phylogenies can be modeled as a mixture of distinct evolutionary rate regimes and that a hierarchical Poisson process governs the number of such rate regimes across a tree...
May 18, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29787482/physical-performance-in-relation-to-menopause-status-and-physical-activity
#7
Dmitriy Bondarev, Eija K Laakkonen, Taija Finni, Katja Kokko, Urho M Kujala, Pauliina Aukee, Vuokko Kovanen, Sarianna Sipilä
OBJECTIVE: The aim of this study was to examine differences in physical performance (muscle power, muscle strength, aerobic capacity, and walking speed) across menopausal stages and potential of leisure physical activity (PA) to modify the impact of menopause on physical performance. METHODS: In this cross-sectional study, women aged 47 to 55 were randomly selected from the Finnish National Registry and categorized as premenopausal (n = 233), perimenopausal (n = 381), or postmenopausal (n = 299) based on serum concentrations of follicle-stimulating hormone and bleeding diary...
May 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29786656/temperature-effects-on-force-and-actin%C3%A2-myosin-interaction-in-muscle-a-look-back-on-some-experimental-findings
#8
REVIEW
K W Ranatunga
Observations made in temperature studies on mammalian muscle during force development, shortening, and lengthening, are re-examined. The isometric force in active muscle goes up substantially on warming from less than 10 °C to temperatures closer to physiological (>30 °C), and the sigmoidal temperature dependence of this force has a half-maximum at ~10 °C. During steady shortening, when force is decreased to a steady level, the sigmoidal curve is more pronounced and shifted to higher temperatures, whereas, in lengthening muscle, the curve is shifted to lower temperatures, and there is a less marked increase with temperature...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786631/comparison-between-elite-and-subelite-swimmers-on-dry-land-and-tumble-turn-leg-extensor-force-time-characteristics
#9
Julian V Jones, David B Pyne, G Greg Haff, Robert U Newton
Jones, JV, Pyne, DB, Haff, GG, and Newton, RU. Comparison between elite and subelite swimmers on dry land and tumble turn leg extensor force-time characteristics. J Strength Cond Res 32(6): 1762-1769, 2018-Elite swimmers demonstrate faster swimming turn times that are potentially a result of having better strength-power characteristics than subelite swimmers. We quantified differences between dry-land and swimming turn force-time characteristics in elite swimmers and subelite swimmers. Subelite (11 males: 17...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786629/anthropometric-parameters-age-and-agility-as-performance-predictors-in-elite-female-basketball-players
#10
Maria Garcia-Gil, Jon Torres-Unda, Izaro Esain, Iratxe Duñabeitia, Susana M Gil, Javier Gil, Jon Irazusta
Garcia-Gil, M, Torres-Unda, J, Esain, I, Duñabeitia, I, Gil, SM, Gil, J, and Irazusta, J. Anthropometric parameters, age, and agility as performance predictors in elite female basketball players. J Strength Cond Res 32(6): 1723-1730, 2018-In addition to technical, tactical, and psychological skills, performance in playing basketball depends on anthropometry and physical fitness. However, limited information is available regarding such features in women. We hypothesized that anthropometry and physical fitness are associated with female basketball performance, and consequently, performance could be predicted using the results of certain anthropometric measures and fitness tests...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786624/relationship-between-dryland-strength-and-swimming-performance-pull-up-mechanics-as-a-predictor-of-swimming-speed
#11
José I Pérez-Olea, Pedro L Valenzuela, Concepción Aponte, Mikel Izquierdo
Pérez-Olea, JI, Valenzuela, PL, Aponte, C, and Izquierdo, M. Relationship between dryland strength and swimming performance: pull-up mechanics as a predictor of swimming speed. J Strength Cond Res 32(6): 1637-1642, 2018-This study aimed to examine the validity of the countermovement jump (CMJ) and the pull-up exercise as predictors of swimming performance. Twelve young male swimmers (Mean ± SD, 19 ± 3 years; 75 ± 10 kg; 180 ± 6 cm) with a homogenous level of performance (50-m freestyle time [50F]: 26.41 ± 1...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786029/academics-anonymous-a-medical-student-s-12-step-guide-to-scholarly-productivity
#12
Nissi Wei, James A Bourgeois, Ana Hategan, Amin Azzam
An important aspect of academic medicine is publication in peer-reviewed journals and other media. Early scholarly productivity in medical school may jump-start a successful academic career. Topic choice, search methodology, writing strategies, mentorship, and collaboration are all fundamental to successful academic productivity. The authors reviewed the importance of instituting the germinal stages of scholarly productivity during medical training and created 12 steps for facilitating productive academic writing by students...
September 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/29784532/short-term-results-of-flexor-hallucis-longus-transfer-in-delayed-and-neglected-achilles-tendon-repair
#13
Hamza Ozer, Yilmaz Ergisi, Gulcan Harput, Mehmet S Senol, Gul Baltaci
Flexor hallucis longus (FHL) tendon transfer to the calcaneus in the repair of delayed or neglected Achilles tendon (AT) injuries is a viable and dynamic option. Nineteen patients (18 males, 1 female; mean age 47.4 ± 12.4, range 24 to 74, years; body mass index 27.5 ± 4.5, range 23.2 to 38.9, kg/m2 ; interval from injury to surgery 40.8 ± 11.6, range 28 to 60, days) with delayed or neglected repair of AT rupture were included in the present study. FHL transfer to the calcaneus through a single incision and repair of the defect with native tendon lengthening or a tendinous turndown flap was performed...
May 18, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29782796/resolution-measurement-from-a-single-reconstructed-cryo-em-density-map-with-multi-scale-spectral-analysis
#14
Yu-Jiao Yang, Shuai Wang, Biao Zhang, Hong-Bin Shen
As a relatively new technology to solve the 3D structure of a protein or protein complex, the Single-Particle Reconstruction (SPR) of cryo-EM images shows much superiority and is in a rapidly developing stage. Resolution measurement in SPR, which evaluates the quality of a reconstructed 3D density map, plays a critical role for promoting methodology development of SPR and structural biology. Due to there is no benchmark map in a new structure generation, how to realize the resolution estimation of a new map is still an open problem...
May 21, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29782223/do-the-peak-and-mean-force-methods-of-assessing-vertical-jump-force-asymmetry-agree
#15
Jason P Lake, Peter D Mundy, Paul Comfort, Timothy J Suchomel
The aim of this study was to assess agreement between peak and mean force methods of quantifying force asymmetry during the countermovement jump (CMJ). Forty-five men performed four CMJ with each foot on one of two force plates recording at 1,000 Hz. Peak and mean were obtained from both sides during the braking and propulsion phases. The dominant side was obtained for the braking and propulsion phase as the side with the largest peak or mean force and agreement was assessed using percentage agreement and the kappa coefficient...
May 21, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29781628/early-life-stress-impairs-contextual-threat-expression-in-female-but-not-male-mice
#16
Gabriela Manzano-Nieves, Mizan Gaillard, Meghan Gallo, Kevin G Bath
Early life stress (ELS) is associated with altered processing of threat signals, and increased lifetime risk of anxiety and affective pathology, disorders that disproportionately affect females. We tested the impact of a limited bedding paradigm of ELS (from P4-11) on contextual threat learning, context memory, footshock sensitivity, and anxietylike behavior, in adult male and female mice. To examine contextual threat learning, mice conditioned by context/footshock association were tested 24 hr later for the context memory...
May 21, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29780459/folding-mechanisms-steer-the-amyloid-fibril-formation-propensity-of-highly-homologous-proteins
#17
Gaetano Malgieri, Gianluca D'Abrosca, Luciano Pirone, Angelo Toto, Maddalena Palmieri, Luigi Russo, Michele Francesco Maria Sciacca, Rosarita Tatè, Valeria Sivo, Ilaria Baglivo, Roksana Majewska, Massimo Coletta, Paolo Vincenzo Pedone, Carla Isernia, Mario De Stefano, Stefano Gianni, Emilia Maria Pedone, Danilo Milardi, Roberto Fattorusso
Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways. Here, we fully characterize, by means of stopped-flow, T-jump, CD and DSC experiments, the unfolding mechanisms of three highly homologous proteins, zinc binding Ros87 and Ml153-149 and zinc-lacking Ml452-151 . The results indicate that the three proteins significantly differ in terms of stability and (un)folding mechanisms...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780458/spin-states-vibrations-and-spin-relaxation-in-molecular-nanomagnets-and-spin-qubits-a-critical-perspective
#18
REVIEW
Luis Escalera-Moreno, José J Baldoví, Alejandro Gaita-Ariño, Eugenio Coronado
Very recently the closely related fields of molecular spin qubits, single ion magnets and single atom magnets have been shaken by unexpected results. We have witnessed a jump in the phase memory times of spin qubits from a few microseconds to almost a millisecond in a vanadium complex, magnetic hysteresis up to 60 K in a dysprosium-based magnetic molecule and magnetic memory up to 30 K in a holmium atom deposited on a surface. With single-molecule magnets being more than two decades old, this rapid improvement in the physical properties is surprising and its explanation deserves urgent attention...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779031/a-novel-ex-vivo-mouse-mesometrium-culture-model-for-investigating-angiogenesis-in-microvascular-networks
#19
Ariana D Suarez-Martinez, Susanne Bierschenk, Katie Huang, Dana Kaplan, Carolyn L Bayer, Stryder M Meadows, Markus Sperandio, Walter L Murfee
BACKGROUND: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, the connective tissue of uterine horns. The study's objective was to demonstrate that mouse mesometrium contains microvascular networks that can be cultured to investigate multicellular dynamics during angiogenesis...
May 18, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29778346/energy-performance-evaluation-of-ultrasonic-pretreatment-of-organic-solid-waste-in-a-pilot-scale-digester
#20
Mazdak Rasapoor, Mehrdad Adl, Saeid Baroutian, Zeynab Iranshahi, Mohammad Pazouki
It has been proven that ultrasonic pretreatment (UP) has positive effect on biogas generation from previous lab-scale studies. However, that is not always the case in larger scale processes. The purpose of this study was to evaluate the effectiveness of UP to biogas generation in terms of anaerobic digestion process and energy efficiency. Parameters including total solids (TS) and ultrasonic treatment operational parameters of organic solid waste (OSW) resulted from our past lab scale UP studies were applied in this study...
April 30, 2018: Ultrasonics Sonochemistry
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