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https://www.readbyqxmd.com/read/28073686/interventions-to-improve-dissemination-and-implementation-of-hepatitis-b-vaccination-in-patients-with-diabetes
#1
Thomas Matta, Katherine O'Neal, Jeremy Johnson, Sandra Carter, Michelle Lamb, Lourdes Planas
OBJECTIVE: The purpose of this study was to assess provider awareness of routine vaccinations recommended for patients with diabetes and to determine whether pharmacist-led interventions are associated with increased provider implementation of recommendations for hepatitis B vaccination. METHODS: This study was conducted in 3 phases at 2 outpatient clinics affiliated with an academic institution. In phase 1, adults with diabetes who visited the clinics between January and November 2012 and who were eligible for the hepatitis B vaccine were identified...
January 7, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28070240/newer-perspectives-of-coronary-artery-disease-in-young
#2
REVIEW
Amitesh Aggarwal, Saurabh Srivastava, M Velmurugan
Coronary artery disease (CAD) occurring in less than 45 years of age is termed as young CAD. Recent studies show a prevalence of 1.2% of CAD cases in this age group. Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%. Conventional risk factors such as smoking, diabetes, hypertension, obesity and family history seems to be as important as in older CAD subjects. But the prevalence of these risk factors seems to vary in younger subjects...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28058019/clinical-features-of-acute-hepatitis-e-super-infections-on-chronic-hepatitis-b
#3
Chong Chen, Shu-Ye Zhang, Dan-Dan Zhang, Xin-Yan Li, Yu-Ling Zhang, Wei-Xia Li, Jing-Jing Yan, Min Wang, Jing-Na Xun, Chuan Lu, Yun Ling, Yu-Xian Huang, Liang Chen
AIM: To examine the clinical features and risk factors for adverse outcomes in chronic hepatitis B (CHB) superimposed with hepatitis E virus (HEV). METHODS: This retrospective cohort study included 228 patients with acute HEV infection (showing clinical acute hepatitis symptomology and positivity for anti-HEV immunoglobulin M) with underlying CHB (confirmed by positivity for hepatitis B surface antigen and/or hepatitis B virus (HBV) DNA over 6 mo) who had been admitted to the Shanghai Public Health Clinical Center, which represents the regional tertiary hospital for infectious diseases in Shanghai city, China...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28054648/niclosamide-reduces-glucagon-sensitivity-via-hepatic-pka-inhibition-in-obese-mice-implications-for-glucose-metabolism-improvements-in-type-2-diabetes
#4
Md Kamrul Hasan Chowdhury, Nigel Turner, Nicholas L Bentley, Abhirup Das, Lindsay E Wu, Dulama Richani, Sonia Bustamante, Robert B Gilchrist, Margaret J Morris, Peter R Shepherd, Greg C Smith
Type 2 diabetes (T2D) is a global pandemic. Currently, the drugs used to treat T2D improve hyperglycemic symptom of the disease but the underlying mechanism causing the high blood glucose levels have not been fully resolved. Recently published data showed that salt form of niclosamide improved glucose metabolism in high fat fed mice via mitochondrial uncoupling. However, based on our previous work we hypothesised that niclosamide might also improve glucose metabolism via inhibition of the glucagon signalling in liver in vivo...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050236/hepatitis-c-eradication-with-sofosbuvir-leads-to-significant-metabolic-changes
#5
Amilcar L Morales, Zachary Junga, Manish B Singla, Maria Sjogren, Dawn Torres
AIM: To assess the effect of sofosbuvir (SOF) based regimens on glycemic and lipid control. METHODS: This is a retrospective analysis of hepatitis C virus (HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir (LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C (HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study...
December 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/28049587/response-to-active-hepatitis-b-vaccination-and-mortality-in-incident-dialysis-patients
#6
Emanuel Zitt, Hildegard Hafner-Giessauf, Birgitta Wimmer, Alexander Herr, Sabine Horn, Claudia Friedl, Hannelore Sprenger-Mähr, Reinhard Kramar, Alexander R Rosenkranz, Karl Lhotta
All patients with advanced chronic kidney disease or on renal replacement therapy should receive active hepatitis B vaccination. The aim of this retrospective cohort study was to investigate the association between the immune response to hepatitis B vaccination and all-cause, cardiovascular or infection-related mortality in incident dialysis patients starting dialysis between 2001 and 2008 (n=426) in two Austrian dialysis centers. Vaccination response was defined as follows: absent anti-HBs antibody titer or a titer <10IU/L was classified as non-response, seroconversion (SC) was defined as a titer ⩾10IU/L, and seroprotection (SP) as a titer ⩾100IU/L...
December 31, 2016: Vaccine
https://www.readbyqxmd.com/read/28042834/phlorotannins-towards-new-pharmacological-interventions-for-diabetes-mellitus-type-2
#7
REVIEW
Graciliana Lopes, Paula B Andrade, Patrícia Valentão
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycaemia, and predicted by the World Health Organization as the expected 7th leading cause of death in 2030. Diabetes mellitus type 2 (DMT2) comprises the majority of diabetic individuals around the world (90%-95%). Pathophysiologically, this disorder results from a deregulation of glucose homeostasis, worsened by overweight and by a sedentary lifestyle, culminating in life-threatening cardiovascular events. The currently available anti-diabetic drugs are not devoid of undesirable side effects, sometimes responsible for poor therapeutic compliance...
December 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28039099/individual-patient-data-meta-analysis-of-controlled-attenuation-parameter-cap-technology-for-assessing-steatosis
#8
Thomas Karlas, David Petroff, Magali Sasso, Jian-Gao Fan, Yu-Qiang Mi, Victor de Lédinghen, Manoj Kumar, Monica Lupsor-Platon, Kwang-Hyub Han, Ana C Cardoso, Giovanna Ferraioli, Wah-Kheong Chan, Vincent Wai-Sun Wong, Robert P Myers, Kazuaki Chayama, Mireen Friedrich-Rust, Michel Beaugrand, Feng Shen, Jean-Baptiste Hiriart, Shiv K Sarin, Radu Badea, Kyu Sik Jung, Patrick Marcellin, Carlo Filice, Sanjiv Mahadeva, Grace Lai-Hung Wong, Pam Crotty, Keiichi Masaki, Joerg Bojunga, Pierre Bedossa, Volker Keim, Johannes Wiegand
BACKGROUND: The prevalence of fatty liver underscores the need for non-invasive characterization of steatosis, such as the ultrasound-based controlled attenuation parameter (CAP). Despite good diagnostic accuracy, clinical use of CAP is limited due to uncertainty regarding optimal cut-offs and the influence of covariates. We therefore conducted an individual patient data meta-analysis. METHODS: A review of the literature identified studies containing histology controlled CAP data (M probe, vibration controlled transient elastography with Fibroscan) for grading of steatosis (S0-S3)...
December 27, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28035496/the-role-of-current-and-historical-alcohol-use-in-hepatic-fibrosis-among-hiv-infected-individuals
#9
H Nina Kim, Heidi M Crane, Carla V Rodriguez, Stephen Van Rompaey, Kenneth H Mayer, Katerina Christopoulos, Sonia Napravnik, Geetanjali Chander, Heidi Hutton, Mary E McCaul, Edward R Cachay, Michael J Mugavero, Richard Moore, Elvin Geng, Joseph J Eron, Michael S Saag, Joseph O Merrill, Mari M Kitahata
We examined risk factors for advanced hepatic fibrosis [fibrosis-4 (FIB)-4 >3.25] including both current alcohol use and a diagnosis of alcohol use disorder among HIV-infected patients. Of the 12,849 patients in our study, 2133 (17%) reported current hazardous drinking by AUDIT-C, 2321 (18%) had a diagnosis of alcohol use disorder, 2376 (18%) were co-infected with chronic hepatitis C virus (HCV); 596 (5%) had high FIB-4 scores >3.25 as did 364 (15%) of HIV/HCV coinfected patients. In multivariable analysis, HCV (adjusted odds ratio (aOR) 6...
December 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/28028371/genotype-specific-peripheral-lipid-profile-changes-with-hepatitis-c-therapy
#10
Mark R Pedersen, Amit Patel, David Backstedt, Myunghan Choi, Anil B Seetharam
AIM: To evaluate magnitude/direction of changes in peripheral lipid profiles in patients undergoing direct acting therapy for hepatitis C by genotype. METHODS: Mono-infected patients with hepatitis C were treated with guideline-based DAAs at a university-based liver clinic. Patient characteristics and laboratory values were collected before and after the treatment period. Baseline demographics included age, ethnicity, hypertension, diabetes, hyperlipidemia, treatment regimen, and fibrosis stage...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28018473/evaluation-of-the-in-vivo-therapeutic-effects-of-radix-paeoniae-rubra-ethanol-extract-with-the-hypoglycemic-activities-measured-from-multiple-cell-based-assays
#11
Chia-Chuan Chang, Wei Yuan, Yun-Lian Lin, Ren-Shyan Liu, Yi-Chen Juan, Wan-Hua Sun, Huey Jen Tsay, Hsiu-Chen Huang, Yu-Ching Lee, Hui-Kang Liu
Background. Radix Paeoniae Rubra (Chi Shao) contains several phytochemicals with hypoglycemic actions. Current research aims to explore potential insulinotropic effects and long-term therapeutic efficacy of such herb against type 2 diabetes. Methods. Composition analysis for the ethanol extract (PRExt) was executed by high performance liquid chromatography. Polyphenol-enriched fraction was characterized by high pressure size exclusion chromatography. Multiple cell platforms were employed to evaluate hypoglycemic bioactivities...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28005029/-insulin-resistance-and-chronic-hepatitis-c
#12
L I Tkachenko, V V Maleev
AIM: To estimate the spread of insulin resistance (IR) in patients with chronic hepatitis C (CHC) and to define the role of IR in the development of hepatic steatosis (HS) and in the progression of liver fibrosis (LF), as well as the impact of IR on the results of antiviral therapy (AVT). SUBJECTS AND METHODS: A total of 211 patients with CHC were examined. A comparison group consisted of 75 patients with chronic hepatitis B (CHB). The patients were divided according to the presence and absence of IR and type 2 diabetes mellitus (DM)...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28000892/non%C3%A2-infective-occupational-risk-factors-for-hepatocellular-carcinoma-a-review-review
#13
Caterina Ledda, Carla Loreto, Christian Zammit, Andrea Marconi, Lucrezia Fago, Serena Matera, Valentina Costanzo, Giovanni Fuccio Sanzà, Stefano Palmucci, Margherita Ferrante, Chiara Costa, Concettina Fenga, Antonio Biondi, Cristoforo Pomara, Venerando Rapisarda
Liver cancer is the second leading worldwide cause of cancer‑associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well‑established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non‑infective occupational risk factors for liver cancer is inconclusive...
December 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27997475/diabetes-among-people-with-tuberculosis-hiv-infection-viral-hepatitis-b-and-c-and-stds-in-new-york-city-2006-2010
#14
Ann Drobnik, Alexander Breskin, Jennifer Fuld, Christine Chan, James Hadler, Bahman Tabaei, Natalie Stennis, Shama Ahuja, Winfred Wu, Jay K Varma
Matching infectious disease surveillance data has become a routine activity for many health departments. With the increasing focus on chronic disease, it is also useful to explore opportunities to match infectious and chronic disease surveillance data. To understand the burden of diabetes in New York City (NYC), adults with select infectious diseases (tuberculosis, HIV infection, hepatitis B, hepatitis C, chlamydial infection, gonorrhea, and syphilis) reported between 2006 and 2010 were matched with hemoglobin A1c results reported in the same period...
December 16, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27977591/relationship-between-nephrotoxicity-and-long-term-adefovir-dipivoxil-therapy-for-chronic-hepatitis-b-a-meta-analysis
#15
Qing Luo, Yong Deng, Feifei Cheng, Juan Kang, Shan Zhong, Dazhi Zhang, Weiqiong Zeng
BACKGROUND: To assess the relationship between adefovir dipivoxil and renal function after anti-hepatitis B virus therapy and elucidate the risk factors involved. METHODS: Based on the requirements of the Cochrane systematic review methodology, 21 observational articles on adefovir dipivoxil-associated renal dysfunction were obtained by searching various databases, between January 1, 1995 and July 1, 2016. The Newcastle Ottawa Scale was used to evaluate risk bias...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27973711/wisteria-floribunda-agglutinin-positive-human-mac-2-binding-protein-predicts-the-risk-of-hbv-related-liver-cancer-development
#16
Seung Up Kim, Ja Yoon Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn, Hyon-Suk Kim
BACKGROUND & AIMS: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA(+) -M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA(+) -M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. METHODS: A total of 1323 CHB patients with WFA(+) -M2BP test results between 2009 and 2011 were included in this retrospective analysis...
December 14, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27958883/glutaredoxin-1-deficiency-causes-fatty-liver-and-dyslipidemia-by-inhibiting-sirtuin-1
#17
Di Shao, Jingyan Han, Xiuyun Hou, Jessica L Fry, Jessica B Behring, Francesca Seta, Michelle Long, Hemant Roy, Richard A Cohen, Reiko Matsui, Markus Michael Bachschmid
<b>Aims:</b> Non-alcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolism cause NAFL. However, redox regulation through glutathione (GSH) adducts in NAFL remains largely elusive. Glutaredoxin-1 (Glrx) is a small thioltransferase that removes protein GSH adducts without having direct antioxidant properties. The liver contains abundant Glrx but its metabolic function is unknown...
December 13, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27956466/plasma-amino-acid-levels-are-elevated-in-young-healthy-low-birth-weight-men-exposed-to-short-term-high-fat-overfeeding
#18
Amalie Ribel-Madsen, Lars I Hellgren, Charlotte Brøns, Rasmus Ribel-Madsen, Christopher B Newgard, Allan A Vaag
Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing insulin resistance and type 2 diabetes. We hypothesized that changes in amino acid metabolism may occur parallel to alterations in fatty acid and glucose oxidation, and could contribute to insulin resistance. Therefore, we measured fasting plasma levels of 15 individual or pools of amino acids in 18 LBW and 25 NBW men after an isocaloric control diet and after a 5-day high-fat, high-calorie diet...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27956454/hepatitis-c-infection-and-the-risk-of-non-liver-related-morbidity-and-mortality-in-hiv-positive-persons-in-the-swiss-hiv-cohort-study
#19
Helen Kovari, Andri Rauch, Roger Kouyos, Mathieu Rougemont, Matthias Cavassini, Patrick Schmid, Marcel Stöckle, Enos Bernasconi, Rainer Weber, Bruno Ledergerber
BACKGROUND: HCV infection has been associated with increased non-liver-related morbidity and mortality. However, studies have yielded inconsistent results. METHODS: The incidence of clinical events in HIV-infected HCV-seropositive and incidence-density-matched HCV-seronegative participants of the Swiss HIV Cohort Study from 08/1994 to 12/2014 was studied. We compared firstly, HCV-seropositive with HCV-seronegative participants, and secondly, HCV-viremic with successfully treated nonviremic patients...
December 12, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27941340/salvianolic-acid-b-ameliorates-hyperglycemia-and-dyslipidemia-in-db-db-mice-through-the-ampk-pathway
#20
Ming-Qing Huang, Cai-Jie Zhou, Yi-Ping Zhang, Xiao-Qin Zhang, Wen Xu, Jing Lin, Pei-Jian Wang
BACKGROUND/AIMS: Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the action mechanism of SalB in type 2 diabetes has not been investigated extensively. The present study was designed to investigate the effects of Sal B on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as its potential molecular mechanism. METHODS: Male C57BL/KsJ-db/db mice were orally treated with Sal B (50 and 100 mg/kg) or metformin (positive drug, 300 mg/kg) for 6 weeks...
2016: Cellular Physiology and Biochemistry
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