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JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
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JOURNAL ARTICLE
Michael M Richter, Ida M Kemp, Sara Heebøll, Marie Winther-Sørensen, Sasha A S Kjeldsen, Nicole J Jensen, Janus D Nybing, Frederik H Linden, Erik Høgh-Schmidt, Mikael P Boesen, Sten Madsbad, Frank Vinholt Schiødt, Kirsten Nørgaard, Signe Schmidt, Lise Lotte Gluud, Steen B Haugaard, Jens J Holst, Søren Nielsen, Jørgen Rungby, Nicolai J Wewer Albrechtsen
INTRODUCTION: Glucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The metabolic effects of glucagon receptor agonism may in part be mediated by increases in circulating levels of Fibroblast Growth Factor 21 (FGF21) and Growth Differentiation Factor 15 (GDF15). The effect of glucagon agonism on FGF21 and GDF15 levels remains uncertain, especially in the context of elevated insulin levels commonly observed in metabolic diseases...
April 15, 2024: Metabolism: Clinical and Experimental
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JOURNAL ARTICLE
Anne-Sofie H Jensen, Henriette Ytting, Mikkel P Werge, Elias B Rashu, Liv E Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Kirstine N Bojsen-Møller, Anders E Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza R Serizawa, Lise L Gluud, Nicolai J Wewer Albrechtsen
Autoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collected during a 120 min oral glucose tolerance test...
April 16, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
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JOURNAL ARTICLE
Vanderlene L Kung, Gabriel Giannini, Cynthia C Nast
INTRODUCTION: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of the world population and can induce several kidney diseases. DM prevalence is increased in individuals with HCV; however, kidney diseases in those with both DM and HCV have not been assessed. Direct-acting antiviral agents (DAAs) became available for HCV treatment in 2014; it is unknown if DAAs altered the spectrum of kidney disease in patients with DM and HCV...
2024: Glomerular diseases
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JOURNAL ARTICLE
S M Oussaada, M Kilicarslan, B A de Weijer, P W Gilijamse, A Şekercan, S Virtue, I M C Janssen, A van de Laar, A Demirkiran, B A van Wagensveld, A P J Houdijk, A Jongejan, P D Moerland, J Verheij, T B Geijtenbeek, V W Bloks, M C de Goffau, J A Romijn, M Nieuwdorp, A Vidal-Puig, K W Ter Horst, M J Serlie
Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship. The first cohort consists of six women with normal weight and twenty with obesity. In women with obesity, we found an upregulation of inflammatory markers in subcutaneous and visceral adipose tissue, isolated AT macrophages, and the liver, but no linear correlation with tissue-specific insulin sensitivity...
April 12, 2024: Diabetes Research and Clinical Practice
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JOURNAL ARTICLE
Xuelian Dong, Qiang Chen, Wenyan Chi, Zhidong Qiu, Ye Qiu
(1) Background: Diabetes is a common metabolic disease that seriously endangers human health. In the present study, we investigated the therapeutic effects of the active ingredient Eleutheroside B (EB) from the traditional Chinese medicine Eleutheroside on diabetes mellitus in a zebrafish model. Concomitant hepatic injury was also analysed, along with the study of possible molecular mechanisms using metabolomics technology. This work should provide some theoretical references for future experimental studies...
March 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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REVIEW
Fiona Stewart, Kristin Kistler, Yuxian Du, Rakesh R Singh, Bonnie B Dean, Sheldon X Kong
AIMS: The increasing prevalence of end-stage renal disease (ESRD) in the United States (US) represents a considerable economic burden due to the high cost of dialysis treatment. This review examines data from real-world studies to identify cost drivers and explore areas where dialysis costs could be reduced. METHODS: We identified and synthesized evidence published from 2016-2023 reporting direct dialysis costs in adult US patients from a comprehensive literature search of MEDLINE, Embase, and grey literature sources (eg, US Renal Data System reports)...
April 12, 2024: Journal of Medical Economics
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JOURNAL ARTICLE
Xi Li, Jun Yang Yang, Wen Zhi Hu, YuXin Ruan, Hong Ying Chen, Qiang Zhang, Zhe Zhang, Zhe Shu Ding
OBJECTIVE: Mitochondria-associated membranes (MAMs) serve pivotal functions in hepatic insulin resistance (IR). Our aim was to explore the potential role of MAMs in mitigating hepatic IR through exercise and to compare the effects of different intensities of exercise on hepatic MAMs formation in high-fat diet (HFD) mice. METHODS: Male C57BL/6J mice were fed an HFD and randomly assigned to undergo supervised high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT)...
April 2024: Journal of Diabetes
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JOURNAL ARTICLE
Sascha Vaghiri, Dimitrios Prassas, Onur Mustafov, Sinan Kalmuk, Wolfram Trudo Knoefel, Nadja Lehwald-Tywuschik, Andrea Alexander, Levent Dizdar
BACKGROUND: High tumor recurrence and dismal survival rates after curative intended resection for hepatocellular carcinoma (HCC) are still concerning. The primary goal was to assess predictive factors associated with disease-free (DFS) and overall survival (OS) in a subset of patients with HCC undergoing hepatic resection (HR). METHODS: Between 08/2004-7/2021, HR for HCC was performed in 188 patients at our institution. Data allocation was conducted from a prospectively maintained database...
April 8, 2024: BMC Surgery
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JOURNAL ARTICLE
Mark Lebwohl, Joseph F Merola, Bruce Strober, April Armstrong, Ayumi Yoshizaki, Paolo Gisondi, Balint Szilagyi, Luke Peterson, Dirk de Cuyper, Nancy Cross, Owen Davies, Alice B Gottlieb
BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferase (ALT) or aspartate aminotransferase (AST), and changes in clinical markers of liver fibrosis (Fibrosis-4 [FIB-4] Index and AST to Platelet Ratio Index [APRI]) are reported...
April 6, 2024: Journal of the American Academy of Dermatology
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JOURNAL ARTICLE
S Kordeva, I Pidakev, G Tchernev
Giant condyloma acuminatum (GCA), alternatively referred to as a Buschke-Löwenstein tumor (BLT), is an uncommon, benign, but locally aggressive form of verrucous carcinoma. The condition usually affects the male population under the age of 50 years; however, there have been rare reports of pediatric cases. Various risk factors such as smoking, diabetes, promiscuous behavior, poor hygiene, immunosuppression, and others are linked to the development of this condition. We present the case of a 26-year-old male patient who came to the dermatology department with primary complaints of 10-year-old verrucous tumor formations located in the perigenital and perianal areas...
April 8, 2024: Wiener Medizinische Wochenschrift
#12
REVIEW
Tolera Ambisa Lamesa
Lipodystrophy syndrome is a medical condition characterized by the absence of adipose tissue without any underlying starvation or macromolecule breakdown. In HIV AIDS patients, the use of highly active antiretroviral therapy (HAART) can lead to an acquired form of lipodystrophy, with a prevalence ranging from 10% to 83% among HIV AIDS patients. It was aimed to review the current understanding of biological depiction and challenges related to lipodystrophy in AIDS patients. Relevant articles published in the English language were searched in PubMed, Google Scholar, and Google...
2024: HIV/AIDS: Research and Palliative Care
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JOURNAL ARTICLE
Chibuike J Alanaeme, Lama Ghazi, Oluwasegun P Akinyelure, Ying Wen, Ashley Christenson, Bharat Poudel, Erin E Dooley, Ligong Chen, Shakia T Hardy, Kathryn Foti, C Barrett Bowling, Michelle T Long, Lisandro D Colantonio, Paul Muntner
BACKGROUND: The prevalence of many chronic conditions has increased over the past several decades among US adults. Many adults with hypertension have other chronic conditions. METHODS: We estimated changes in the age-adjusted prevalence of multiple (≥3) chronic conditions, not including hypertension, using data from the National Health and Nutrition Examination Survey, from 1999-2000 to 2017-2020, among US adults with and without hypertension (24,851 and 24,337 participants, respectively)...
April 5, 2024: American Journal of Hypertension
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JOURNAL ARTICLE
Tamires Pavei Macan, Marina Lummertz Magenis, Adriani Paganini Damiani, Isadora de Oliveira Monteiro, Gustavo De Bem Silveira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, João Paulo Fernandes Teixeira, Goran Gajski, Vanessa Moraes de Andrade
Type 2 diabetes mellitus (T2D) is a metabolic disease, which occurs largely due to unhealthy lifestyle. As oxidative stress is believed to promote T2D, by inducing damage to lipids, proteins, and DNA, appropriate dietary interventions seem critical to prevent, manage, and even reverse this condition. Brazil nuts (Bertholletia excelsa, H.B.K.) are nature's richest source of selenium, a mineral that has shown several health benefits. Therefore, this study aims to assess the effects of selenium consumption, through Brazil nuts, on biochemical and oxidative stress parameters, and genomic instability in T2D patients...
April 2024: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
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JOURNAL ARTICLE
Greet Peeters, Ann Verhaegen
A man in his late 60s with a history of well-controlled type 2 diabetes and hepatic cirrhosis presented to the emergency department due to uncontrollable hyperglycaemia following the initial brentuximab vedotin (BV) infusion. BV was initiated as a treatment for mycosis fungoides, a form of cutaneous T-cell lymphoma. The patient was diagnosed with severe hyperglycaemia with ketosis. Empiric treatment with amoxicillin-clavulanic acid, hydration and intravenous insulin infusion was initiated. Hyperglycaemia persisted despite receiving massive amounts of insulin and was corrected only after treatment with high-dose methylprednisolone for suspected type B insulin resistance...
April 2, 2024: BMJ Case Reports
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JOURNAL ARTICLE
Wen Zheng, Jing Liu, Wenqi Zhao, Zongyi Zhao, Zhiqiong Lan, Jun Wen
Alismataceae is one of the early diverged families of monocotyledonous plants. We report the complete chloroplast genomes of three Alisma species, including Alisma orientale (Sam.) Juzep. 1934, A. subcordatum Raf. 1908, and A. triviale Pursh 1813, of which A. orientale is a traditional Chinese medical plant used widely to treat diuretics, diabetes, hepatitis, and inflammation. We sequenced the complete chloroplast genomes with the Illumina Nova-Seq 6000 platform using herbarium collections. The chloroplast genomes of A...
2024: Mitochondrial DNA. Part B. Resources
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JOURNAL ARTICLE
Guangyi Ouyang, Nannan Wang, Jihang Tong, Wenke Sun, Jiancheng Yang, Gaofeng Wu
Type 2 diabetes mellitus (T2DM) is a serious metabolic disease characterized by insulin resistance and reduced insulin production, which causes abnormally elevated blood glucose. It has been reported that T2DM can enhance oxidative stress and inflammatory responses, and stimulate a variety of complications including liver injury. Studies have shown that taurine has antioxidant and anti-inflammatory effects that can not only ameliorate diabetes but also alleviate liver injury caused by various diseases. However, its effect on liver injury in T2DM is not clear...
April 15, 2024: Heliyon
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JOURNAL ARTICLE
Marc Jonuscheit, Celina Uhlemeyer, Benedict Korzekwa, Marten Schouwink, Soner Öner-Sieben, Regina Ensenauer, Michael Roden, Bengt-Frederik Belgardt, Vera B Schrauwen-Hinderling
Maternal obesity and hyperglycemia are linked to an elevated risk for obesity, diabetes, and steatotic liver disease in the adult offspring. To establish and validate a noninvasive workflow for perinatal metabolic phenotyping, fixed neonates of common mouse strains were analyzed postmortem via magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS) to assess liver volume and hepatic lipid (HL) content. The key advantage of nondestructive MRI/MRS analysis is the possibility of further tissue analyses, such as immunohistochemistry, RNA extraction, and even proteomics, maximizing the data that can be gained per individual and therefore facilitating comprehensive correlation analyses...
March 31, 2024: NMR in Biomedicine
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JOURNAL ARTICLE
K T Lee, S K Tan, A S Goh
INTRODUCTION: Haemophilia is one of the commonest inherited bleeding disorders which may lead to long term disabilities if not treated properly. Our aim of study is to understand the clinical characteristic, treatment and complications of adult haemophilia patients in our centre. MATERIALS AND METHODS: A retrospective cross-sectional review of all adult haemophilia A (HA) or haemophilia B (HB) patients who received treatment in Hospital Pulau Pinang from January 2021 to December 2022 was conducted...
March 2024: Medical Journal of Malaysia
#20
JOURNAL ARTICLE
Ailton S S Júnior, Felipe J Aidar, Luiz A S Silva, Thais de B Silva, Sara F M de Almeida, Daiane C S Teles, Waldecy de L Junior, Dulce M Schimieguel, Daniel A de Souza, Ana C S Nascimento, Enilton A Camargo, Jymmys L Dos Santos, Ana M de O E Silva, Rogéria de S Nunes, Lysandro P Borges, Ana A M Lira
(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated...
March 4, 2024: Life
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