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Acid-base balance

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https://www.readbyqxmd.com/read/28444340/ligpargen-web-server-an-automatic-opls-aa-parameter-generator-for-organic-ligands
#1
Leela S Dodda, Israel Cabeza de Vaca, Julian Tirado-Rives, William L Jorgensen
The accurate calculation of protein/nucleic acid-ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions. Despite the progress made in force fields, small molecule parameterization remains an open problem due to the magnitude of the chemical space; the most critical issue is the estimation of a balanced set of atomic charges with the ability to reproduce experimental properties. The LigParGen web server provides an intuitive interface for generating OPLS-AA/1...
April 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28438983/light-dependent-expression-of-a-na-h-exchanger-3-like-transporter-in-the-ctenidium-of-the-giant-clam-tridacna-squamosa-can-be-related-to-increased-h-excretion-during-light-enhanced-calcification
#2
Kum C Hiong, Anh H Cao-Pham, Celine Y L Choo, Mel V Boo, Wai P Wong, Shit F Chew, Yuen K Ip
Na(+)/H(+) exchangers (NHEs) regulate intracellular pH and ionic balance by mediating H(+) efflux in exchange for Na(+) uptake in a 1:1 stoichiometry. This study aimed to obtain from the ctenidium of the giant clam Tridacna squamosa (TS) the complete cDNA sequence of a NHE3-like transporter (TSNHE3), and to determine the effect of light exposure on its mRNA expression level and protein abundance therein. The coding sequence of TSNHE3 comprised 2886 bp, encoding 961 amino acids with an estimated molecular mass of 105...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28432428/tranexamic-acid-for-treatment-and-prophylaxis-of-bleeding-and-hyperfibrinolysis
#3
Ingrid Pabinger, Dietmar Fries, Herbert Schöchl, Werner Streif, Wolfgang Toller
Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a major challenge in the management of both surgical and seriously injured patients. Under physiological conditions activators and inhibitors of coagulation regulate the sensitive balance between clot formation and fibrinolysis. In some cases, excessive and diffuse bleeding is caused by systemic activation of fibrinolysis, i. e. hyperfibrinolysis (HF). Uncontrolled HF is associated with a high mortality. Polytrauma patients and those undergoing surgical procedures involving organs rich in plasminogen proactivators (e...
April 21, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28431202/pharmacological-interventions-for-acute-pancreatitis
#4
REVIEW
Elisabetta Moggia, Rahul Koti, Ajay P Belgaumkar, Federico Fazio, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. OBJECTIVES: To assess the effects of different pharmacological interventions in people with acute pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28429609/chemical-evaluation-of-the-rhynchophorus-ferrugineus-larvae-fed-on-different-substrates-as-human-food-source
#5
Annarita Cito, Santi Longo, Giuseppe Mazza, Elena Dreassi, Valeria Francardi
We investigated the chemical composition of the weevil Rhynchophorus ferrugineus larvae, traditionally used as human food in Asia and known worldwide as one of the most significant pest for palm trees. Total fat content and fatty acid composition were analyzed using standard methodologies in (1) weevil larvae reared on apple fruit slices and wild specimens collected from attacked (2) Phoenix canariensis and (3) Syagrus romanzoffiana palm trees. Total fat content was extremely high in all the specimens (ranged between 57...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28425228/the-effects-of-the-chloride-sodium-ratio-on-acid-base-statusand-mortality-in-septic-patients
#6
Hakan Korkut Atalan, Bülent Güçyetmez
BACKGROUND/AIM: Calculation of the chloride:sodium (Cl(-):Na(+)) ratio is proposed to enable a quick evaluation of the effect of Cl(-) and Na(+) on the acid-base balance in critically ill patients. In the present study, the relationship of the Cl(-):Na(+) ratio of septic patients with acid-base status and ICU mortality were investigated. MATERIALS AND METHODS: In our two-center study, 434 patients who were diagnosed with sepsis were included. The patients were divided into three groups: low (<0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424615/huangqin-decoction-attenuates-cpt-11-induced-gastrointestinal-toxicity-by-regulating-bile-acids-metabolism-homeostasis
#7
Xu Wang, Dong-Ni Cui, Xiao-Min Dai, Jing Wang, Wei Zhang, Zun-Jian Zhang, Feng-Guo Xu
Irinotecan (CPT-11) is a potent chemotherapeutic agent, however, its clinical usage is often limited by the induction of severe gastrointestinal (GI) toxicity, especially late-onset diarrhea. HuangQin Decoction (HQD), commonly used for the treatment of GI ailments, has been proved could significantly ameliorate the intestinal toxicity of CPT-11. To reveal the mechanisms of CPT-11-induced toxicity and the modulation effects of HQD, a previous untargeted metabolomics study was performed and the results indicated that HQD may protect the GI tract by altering the metabolism of bile acids (BAs)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28416114/invariance-of-initiation-mass-and-predictability-of-cell-size-in-escherichia-coli
#8
Fangwei Si, Dongyang Li, Sarah E Cox, John T Sauls, Omid Azizi, Cindy Sou, Amy B Schwartz, Michael J Erickstad, Yonggun Jun, Xintian Li, Suckjoon Jun
It is generally assumed that the allocation and synthesis of total cellular resources in microorganisms are uniquely determined by the growth conditions. Adaptation to a new physiological state leads to a change in cell size via reallocation of cellular resources. However, it has not been understood how cell size is coordinated with biosynthesis and robustly adapts to physiological states. We show that cell size in Escherichia coli can be predicted for any steady-state condition by projecting all biosynthesis into three measurable variables representing replication initiation, replication-division cycle, and the global biosynthesis rate...
April 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28415584/folic-acid-phenotype-fap-is-a-superior-biomarker-predicting-response-to-pemetrexed-based-chemotherapy-in-malignant-pleural-mesothelioma
#9
Fabian Dominik Mairinger, Claudia Vollbrecht, Elena Flom, Daniel Christian Christoph, Kurt-Werner Schmid, Jens Kollmeier, Helmut Hans Popper, Thomas Mairinger, Robert Fred Henry Walter
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare tumor linked to a dismal prognosis. Even the most effective chemotherapeutical regime of pemetrexed combined with cisplatin leads to a remission-rate of only about 40%. The reasons for the rather poor efficacy remain largely unknown. RESULTS: Phenotypes were significantly associated with progression (p=0.0279) and remission (p=0.0262). Cox-regression revealed significant associations between SLC19A1/TYMS-ratio (p=0...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413444/functional-photosystem-i-maintains-proper-energy-balance-during-nitrogen-depletion-in-chlamydomonas-reinhardtii-promoting-triacylglycerol-accumulation
#10
Mahmoud Gargouri, Philip D Bates, Jeong-Jin Park, Helmut Kirchhoff, David R Gang
BACKGROUND: Nutrient deprivation causes significant stress to the unicellular microalga, Chlamydomonas reinhardtii, which responds by significantly altering its metabolic program. Following N deprivation, the accumulation of starch and triacylglycerols (TAGs) is significantly altered following massive reprogramming of cellular metabolism. One protein that was found to change dramatically and early to this stress was TAB2, a photosystem I (PSI) translation initiation factor, whose transcript and protein levels increased significantly after only 30 min of N deprivation...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28412757/fatty-acid-metabolism-in-breast-cancer-subtypes
#11
REVIEW
Marie E Monaco
Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. Evidence indicates that proteins involved in both synthesis and oxidation of fatty acids play a pivotal role in the proliferation, migration and invasion of breast cancer cells. The following essay summarizes data implicating specific fatty acid metabolic enzymes in the genesis and progression of breast cancer, and further categorizes the relevance of specific metabolic pathways to individual intrinsic molecular subtypes of breast cancer...
February 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411229/a-comprehensive-analysis-of-myocardial-substrate-preference-emphasizes-the-need-for-a-synchronized-fluxomic-metabolomic-research-design
#12
Mukundan Ragavan, Alexander Kirpich, Xiaorong Fu, Shawn C Burgess, Lauren M McIntyre, Matthew E Merritt
The heart oxidizes fatty acids, carbohydrates and ketone bodies inside the citric acid cycle (CAC) to generate the reducing equivalents needed for ATP production. Competition between these substrates makes it difficult to estimate the extent of pyruvate oxidation. Previously, hyperpolarized pyruvate detected propionate mediated activation of carbohydrate oxidation, even in the presence of acetate. In this report, the optimal concentration of propionate for activation of glucose oxidation is measured in mouse hearts perfused in Langendorff mode...
April 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28411111/s-sulfpred-a-sensitive-predictor-to-capture-s-sulfenylation-sites-based-on-a-resampling-one-sided-selection-undersampling-synthetic-minority-oversampling-technique
#13
Cangzhi Jia, Yun Zuo
Protein S-sulfenylation is a reversible post-translational modification involving covalent attachment of hydroxide to the thiol group of cysteine residues, which is involved in various biological processes including cell signaling, response to stress and protein functions. Herein we present S-SulfPred, a support vector machine based model to capture potential S-sulfenylation sites and improve the efficiency and relevance of experimental identification of protein S-sulfenylation sites. One-sided selection (OSS) undersampling and synthetic minority oversampling technique (SMOTE) oversampling were combined to establish balanced training datasets...
April 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28410612/milk-protein-based-formulas-containing-different-oils-affect-fatty-acids-balance-in-term-infants-a-randomized-blinded-crossover-clinical-trial
#14
Carolina Oliveira de Souza, Maria Efigênia Q Leite, John Lasekan, Geraldine Baggs, Lorena Silva Pinho, Janice Izabel Druzian, Tereza Cristina M Ribeiro, Ângela P Mattos, José A Menezes-Filho, Hugo Costa-Ribeiro
BACKGROUND: Palm olein is used in infant formula fat blends in order to match the fatty acid profile of human milk. While the effects on fatty acid balance have been evaluated, the use of palm olein in combination with palm kernel oil and supplementation with docosahexaenoic acid (DHA) and arachidonic acid (ARA) has not been similarly assessed in infants. This study evaluated the effects of infant formulas containing different fat compositions on the balance of fat, fatty acids, and calcium...
April 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28410472/histological-alterations-in-gills-of-macrobrachium-amazonicum-juveniles-exposed-to-ammonia-and-nitrite
#15
Fabrício Martins Dutra, Milton Rönnau, Dircelei Sponchiado, Sandra Carla Forneck, Carolina Arruda Freire, Eduardo Luis Cupertino Ballester
Aquaculture has shown great growth in the last decades. Due to the restrictions on water use, production systems are becoming increasingly more intensive, raising concerns about the production water quality. Macrobrachium amazonicum is among the freshwater prawn species with favorable characteristics for production and possibility of intensification. Nitrogen compounds such as ammonia and nitrite affect the health of aquatic organisms since they quickly reach toxic concentrations. These compounds can also cause damage to the gill structure, leading to hypoxia in tissues, affecting acid-base balance, osmoregulation (salt absorption) and ammonia excretion, decreasing the immune capacity of the animal and, in extreme cases, cause death...
April 8, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28406968/the-sense-of-balance-in-humans-structural-features-of-otoconia-and-their-response-to-linear-acceleration
#16
Rüdiger Kniep, Dirk Zahn, Jana Wulfes, Leif Erik Walther
We explored the functional role of individual otoconia within the otolith system of mammalians responsible for the detection of linear accelerations and head tilts in relation to the gravity vector. Details of the inner structure and the shape of intact human and artificial otoconia were studied using environmental scanning electron microscopy (ESEM), including decalcification by ethylenediaminetetraacetic acid (EDTA) to discriminate local calcium carbonate density. Considerable differences between the rhombohedral faces of human and artificial otoconia already indicate that the inner architecture of otoconia is not consistent with the point group -3m...
2017: PloS One
https://www.readbyqxmd.com/read/28403965/understanding-fetal-physiology-and-second-line-monitoring-during-labor
#17
REVIEW
C Garabedian, J De Jonckheere, L Butruille, P Deruelle, L Storme, V Houfflin-Debarge
Cardiotocography (CTG) is a technique used to monitor intrapartum fetal condition and is one of the most common obstetric procedures. Second line methods of fetal monitoring have been developed in an attempt to reduce unnecessary interventions due to continuous cardiotocography and to better identify fetuses at risk of intrapartum asphyxia. The acid-base balance of the fetus is evaluated by fetal blood scalp samples, the modification of the myocardial oxygenation by the fetal ECG ST-segment analysis (STAN) and the autonomic nervous system by the power spectral analysis of the fetal heart variability...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28400704/effects-of-dystocia-on-blood-gas-parameters-acid-base-balance-and-serum-lactate-concentration-in-heavy-draft-newborn-foals
#18
Yuki Kimura, Takahiro Aoki, Akiko Chiba, Yasuo Nambo
Dystocia is often lethal for neonatal foals; however, its clinicopathological features remain largely unknown. We investigated the effect of dystocia on the foal blood profile. Venous blood samples were collected from 35 foals (5 Percheron and 30 crossbreds between Percheron, Belgian, and Breton heavy draft horses) at 0 hr, 1 hr, 12 hr and 1 day after birth. Dystocia was defined as prolonged labor >30 min with strong fetal traction with or without fetal displacement. The dystocia group (n=13) showed lower mean values for pH (P<0...
2017: Journal of Equine Science
https://www.readbyqxmd.com/read/28400172/a-biorefinery-based-approach-for-the-production-of-ethanol-from-enzymatically-hydrolysed-cotton-stalks
#19
Meera Christopher, Anil K Mathew, M Kiran Kumar, Ashok Pandey, Rajeev K Sukumaran
Cotton post-harvest residue/cotton stalk (CS) - a major agro-residue in south asian countries was evaluated as a feed stock for bioethanol production. The common thermochemical pretreatment strategies based on dilute acid and alkali and different combinations of biomass hydrolyzing enzymes were evaluated for saccharification of CS biomass. A hydrolytic efficiency of 80% was achieved for alkali treated biomass using cellulase supplemented with beta glucosidase. Recycling of undigested/residual biomass and/or enzyme supported same final sugar concentration as for fresh hydrolytic experiments...
April 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28380514/effects-of-different-feeding-levels-during-three-short-periods-of-gestation-on-gilt-and-litter-performance-nutrient-digestibility-and-energy-homeostasis-in-gilts
#20
P Ren, X J Yang, S Q Cui, J S Kim, D Menon, S K Baidoo
The present study investigated the effects of different feeding levels during 3 short periods of gestation on gilt and litter performance, apparent total tract digestibility (ATTD) of energy and nutrients, and energy homeostasis in gilts. A total of 18 gilts were allotted to 1 of 3 dietary treatments using a completely randomized design. All gilts were fed 1 common corn-soybean meal-based diet with the amount of 1.0 × maintenance energy intake (100 × BW (BW) kcal ME/d) throughout gestation except 3 periods of 7 d when dietary treatments were imposed on d 27, d 55, and d 83 of gestation...
March 2017: Journal of Animal Science
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