keyword
MENU ▼
Read by QxMD icon Read
search

Acid-base balance

keyword
https://www.readbyqxmd.com/read/29779413/tailoring-tacrolimus-therapy-in-kidney-transplantation
#1
Thomas Jouve, Johan Noble, Lionel Rostaing, Paolo Malvezzi
BACKGROUND: The prevalence of end-stage renal disease is increasing worldwide. The best treatment is kidney transplantation, although life-long immunosuppressive therapy is then mandatory. Currently, the cornerstone immunosuppressive therapy relies on tacrolimus, a calcineurin inhibitor that is nephrotoxic but whose exposition can be minimized in a delicate balance. Area covered: We addressed whether, in the setting of kidney transplantation, tacrolimus-based therapy can be tailored to medical needs: to achieve this, we searched for suitable articles in PubMed...
May 19, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29776674/migration-behavior-of-organic-dyes-based-on-physicochemical-properties-of-solvents-as-background-electrolytes-in-non-aqueous-capillary-electrophoresis
#2
Minjeong Gu, Keunchang Cho, Seong Ho Kang
The migration behavior of organic fluorescent dyes (i.e., crystal violet, methyl violet base, methyl violet B base, rhodamine 6G, and rhodamine B base) in non-aqueous capillary electrophoresis (NACE) was investigated by focusing on the physicochemical properties of various organic solvents [ethanol, methanol, 2-propanol, dimethylformamide (DMF), and dimethyl sulfoxide (DMSO)] in background electrolyte (BGE). Laser-induced fluorescence (LIF) and UV/Vis detectors were employed to observe both the migration time of organic dyes and the electroosmotic flow (EOF) in NACE, respectively...
May 15, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29773684/when-fed-foods-with-similar-palatability-healthy-adult-dogs-and-cats-choose-different-macronutrient-compositions
#3
Jean A Hall, Jodi C Vondran, Melissa A Vanchina, Dennis E Jewell
Dogs and cats make short-term food choices based on palatability. We hypothesized that if palatability were masked, long-term food choices would be based on physiologic requirements, and circulating metabolite concentrations would reflect those choices. Four experimental foods with similar palatability, but varying in macronutrient composition, were prepared for healthy adult dogs (n=17) and cats (n=27). Food 1 was high protein; Food 2 was high fat; Food 3 was high carbohydrates; and Food 4 was balanced for macronutrients...
May 17, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29772775/ph-responsive-mercaptoundecanoic-acid-functionalized-gold-nanoparticles-and-applications-in-catalysis
#4
Siyam M Ansar, Saptarshi Chakraborty, Christopher L Kitchens
Mercaptoundecanoic acid (MUA) functionalized gold nanoparticles (AuNP-MUA) were synthesized and demonstrated to possess pH-triggered aggregation and re-dispersion, as well as the capability of phase transfer between aqueous and organic phases in response to changes in pH. The pH of aggregation for AuNP-MUA is consistent with the pKa of MUA (pH ~4) in solution, while AuNP-MUA phase transition between aqueous and organic phases occurs at pH ~9. The ion pair formation between the amine group in octadecylamine (ODA), the carboxylate group in MUA, and the hydrophobic alkyl chain of ODA facilitates the phase transfer of AuNP-MUA into an organic medium...
May 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29772253/interstitial-ion-homeostasis-and-acid-base-balance-are-maintained-in-oedematous-brain-of-mice-with-acute-toxic-liver-failure
#5
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29765659/self-assembly-behaviours-of-peptide-drug-conjugates-influence-of-multiple-factors-on-aggregate-morphology-and-potential-self-assembly-mechanism
#6
Qin Fan, Yujie Ji, Jingjing Wang, Li Wu, Weidong Li, Rui Chen, Zhipeng Chen
Peptide-drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug ( S )-ketoprofen (Ket) and valine-glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29765379/-vitis-vinifera-l-fruit-diversity-to-breed-varieties-anticipating-climate-changes
#7
Antoine Bigard, Dargie T Berhe, Eleonora Maoddi, Yannick Sire, Jean-Michel Boursiquot, Hernan Ojeda, Jean-Pierre Péros, Agnès Doligez, Charles Romieu, Laurent Torregrosa
The wine industry is facing critical issues due to climate changes since production is established on very tight Genotype × Environment interaction bases. While, some cultivation practices may reduce adverse effects of abiotic stresses on the vines, e.g., the use of irrigation to mitigate drought, the deleterious impacts of warming on fruit development are difficult to manage. Elevated temperature alters grapevine fruit growth and composition, with a critical increase of the sugars/organic acids ratio. Select grapes with improved metabolite balances to offset high temperature effects is a valuable option to sustain viticulture...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29762715/effect-of-diet-type-and-added-copper-on-growth-performance-carcass-characteristics-energy-digestibility-gut-morphology-and-mucosal-mrna-expression-of-finishing-pigs
#8
Kyle F Coble, Derris D Burnett, Joel M DeRouchey, Mike D Tokach, John M Gonzalez, Fangzhou Wu, Steve S Dritz, Robert D Goodband, Jason C Woodworth, John R Pluske
A total of 757 pigs (PIC 337 × 1050; initially 27.6 kg body weight) were used in a 117-d experiment to determine the effects of added Cu from tribasic copper chloride and diet type on growth performance, carcass characteristics, energy digestibility, gut morphology, and mucosal mRNA expression of finishing pigs. Pens of pigs were allotted to 1 of 4 dietary treatments, balanced on average pen weight in a randomized complete block design with 26 to 28 pigs per pen and 7 replications per treatment. Treatments were arranged in a 2 × 2 factorial with main effects of diet type, a corn-soybean meal-based diet (corn-soy) or a high byproduct diet (byproduct) with 30% distillers dried grains with solubles (DDGS) and 15% bakery meal, and added Cu (0 or 150 mg/kg added Cu)...
May 11, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29755482/silicon-improves-chilling-tolerance-during-early-growth-of-maize-by-effects-on-micronutrient-homeostasis-and-hormonal-balances
#9
Narges Moradtalab, Markus Weinmann, Frank Walker, Birgit Höglinger, Uwe Ludewig, Guenter Neumann
Low soil temperature in spring is a major constraint for the cultivation of tropical and subtropical crops in temperate climates, associated with inhibition of root growth and activity, affecting early growth and frequently plant performance and final yield. This study was initiated to investigate the physiological base of cold-protective effects induced by supplementation with silicon (Si), widely recommended as a stress-protective mineral nutrient. Maize was used as a cold-sensitive model plant, exposed to chilling stress and low root-zone temperature (RZT) during early growth in a lab to field approach...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29751994/dietary-potential-renal-acid-load-and-risk-of-albuminuria-and-reduced-kidney-function-in-the-jackson-heart-study
#10
Tanushree Banerjee, Katherine Tucker, Michael Griswold, Sharon B Wyatt, Jane Harman, Bessie Young, Herman Taylor, Neil R Powe
OBJECTIVE: Diets high in sulfur-rich protein and low in fruit and vegetables affect human acid-base balance adversely and may have a harmful effect on progression of chronic kidney disease (CKD). Little is known about the relationship of participant characteristics, dietary acid load (DAL), and kidney injury in African-Americans with high risk of CKD progression. DESIGN AND METHODS: We examined the association of DAL with CKD in 3,257 African-Americans aged >20 years in Jackson Heart Study...
May 8, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29743626/role-of-igf-1r-in-ameliorating-apoptosis-of-gne-deficient-cells
#11
Reema Singh, Priyanka Chaudhary, Ranjana Arya
Sialic acids (SAs) are nine carbon acidic amino sugars, found at the outermost termini of glycoconjugates performing various physiological and pathological functions. SA synthesis is regulated by UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) that catalyzes rate limiting steps. Mutations in GNE result in rare genetic disorders, GNE myopathy and Sialuria. Recent studies indicate an alternate role of GNE in cell apoptosis and adhesion, besides SA biosynthesis. In the present study, using a HEK cell-based model for GNE myopathy, the role of Insulin-like Growth Factor Receptor (IGF-1R) as cell survival receptor protein was studied to counter the apoptotic effect of non-functional GNE...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737890/formulation-and-evaluation-of-carrot-seed-oil-based-cosmetic-emulsions
#12
Shalini Singh, Alka Lohani, Arun Kumar Mishra, Anurag Verma
The present study deals with the evaluation of antiaging potential of carrot seed oil-based cosmetic emulsions. Briefly, cosmetic emulsions composed of carrot seed oil in varying proportions (2, 4, and 6% w/v) were prepared using the hydrophile-lipophile balance (HLB) technique. Coconut oil, nonionic surfactants (Tween 80 and Span 80), and xanthan gum were used as the oil phase, emulgent, and emulsion stabilizer, respectively. The formed emulsions were evaluated for various physical, chemical, and biochemical parameters such as the zeta potential, globule size measurement, antioxidant activity, sun protection factor (SPF), skin irritation, and biochemical studies...
May 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29733929/development-of-a-novel-chitosan-based-biocompatible-and-self-healing-hydrogel-for-controlled-release-of-hydrophilic-drug
#13
Swati Sharma, Ashok Kumar, Deepak, Rajesh Kumar, Nishant Kumar Rana, Biplob Koch
Smart polymeric hydrogels of chitosan and acryloyl-phenylalanine having potential of fast intrinsic shape memory properties (self-healing), non-toxic, biocompatible with moderate mechanical strength have been developed. The hydrogel has been formed by linking its network with flexible pendant side chains of chitosan and acryloyl-phenylalanine (exhibiting optimal balance of hydrophilic and hydrophobic moieties). The non-toxic and biocompatible behavior of the synthesized chitosan based hydrogel reveals its potential use towards the biomedical field...
May 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29733756/-1-h-nmr-plasma-metabolomic-profiling-of-ovarian-quiescence-in-energy-balanced-postpartum-dairy-cows
#14
Jiang Zhang, Gang Wang, Chang Zhao, Yunlong Bai, Shi Shu, Ziling Fan, Cheng Xia
BACKGROUND: As the milk production of dairy cows increases, the reproductive capacity gradually declines. Ovarian quiescence has become one of the concerns of the dairy industry. OBJECTIVE: To explore the different plasma metabolites levels between estrus and anestrus in energy balanced (EB) dairy cows. METHODS: Ten estrous and ten anestrus EB Holstein cows in early lactation were selected for the study. EB cows, 14 to 21 days post-partum (Holstein; parity 3...
May 7, 2018: Veterinary Quarterly
https://www.readbyqxmd.com/read/29733430/combinatorial-synthetic-pathway-fine-tuning-and-comparative-transcriptomics-for-metabolic-engineering-of-raoultella-ornithinolytica-bf60-to-efficiently-synthesize-2-5-furandicarboxylic-acid
#15
Haibo Yuan, Yanfeng Liu, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Zhongping Shi, Jian Chen, Long Liu
The compound, 5-hydroxymethylfurfural (HMF), has attracted much attention due to its versatility as an important bio-based platform chemical. Here, we engineered Raoultella ornithinolytica BF60 as a whole-cell biocatalyst for highly efficient synthesis of 2,5-furandicarboxylic acid (FDCA) from HMF. Specifically, various expression cassettes of key genes, such as hmfH (gene encoding HMF/furfural oxidoreductase [HmfH]) and hmfo (gene encoding HMF oxidase [HMFO]) were designed and constructed for fine-tuning FDCA synthesis from HMF...
May 7, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29728893/adaptive-evolution-of-osmoregulatory-related-genes-provides-insight-into-salinity-adaptation-in-chinese-mitten-crab-eriocheir-sinensis
#16
Zhengfei Wang, Yuze Bai, Daizhen Zhang, Boping Tang
Osmoregulation is an important mechanism by which euryhaline crustaceans regulate osmotic and ionic concentrations. The Chinese mitten crab (Eriocheir sinensis) is a strong osmoregulating animal model among crustacean species, as it can maintain its hemolymph composition and survives well in either seawater or freshwater. Osmoregulation by E. sinensis during physiological adaptation has been studied extensively. However, the genetic basis of osmoregulation in E. sinensis for acclimating to changing salinities remains unclear...
May 4, 2018: Genetica
https://www.readbyqxmd.com/read/29726677/remote-asymmetric-induction-reactions-using-a-e-e-vinylketene-silyl-n-o-acetal-and-the-wide-range-stereocontrol-strategy-for-the-synthesis-of-polypropionates
#17
Seijiro Hosokawa
The construction of libraries of acyclic polyketides remains a challenging topic, mostly due to the difficulties associated with finding the right balance between diversity and brevity for the synthetic routes leading to polyketides. Recently, relatively short methods have been developed and applied to the synthesis of natural products. However, these short routes often suffer from limited diversity with respect to the arrangement of functional groups and stereochemistry, as these usually require reactions that direct multiple functional groups simultaneously in one step...
May 4, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29723610/repurposing-rosiglitazone-a-ppar-%C3%AE-agonist-and-oral-antidiabetic-as-an-inhaled-formulation-for-the-treatment-of-pah
#18
Jahidur Rashid, Ahmad Alobaida, Taslim A Al-Hilal, Samia Hammouda, Ivan F McMurtry, Eva Nozik-Grayck, Kurt R Stenmark, Fakhrul Ahsan
Peroxisome-proliferator-activated-receptor-gamma (PPAR-γ) is implicated, in some capacity, in the pathogenesis of pulmonary arterial hypertension (PAH). Rosiglitazone, an oral antidiabetic and PPAR-γ agonist, has the potential to dilate pulmonary arteries and to attenuate arterial remodeling in PAH. Here, we sought to test the hypothesis that rosiglitazone can be repurposed as inhaled formulation for the treatment of PAH. We have tested this conjecture by preparing and optimizing poly(lactic-co-glycolic) acid (PLGA) based particles of rosiglitazone, assessing the drug particles for pulmonary absorption, investigating the efficacy of the plain versus particulate drug formulation in improving the respiratory hemodynamics in PAH animals, and finally studying the effect of the drug in regulating the molecular markers associated with PAH pathogenesis...
April 30, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29721432/high-efficiency-fullerene-solar-cells-enabled-by-a-spontaneously-formed-mesostructured-cuscn-nanowire-heterointerface
#19
Wai-Yu Sit, Flurin D Eisner, Yen-Hung Lin, Yuliar Firdaus, Akmaral Seitkhan, Ahmed H Balawi, Frédéric Laquai, Claire H Burgess, Martyn A McLachlan, George Volonakis, Feliciano Giustino, Thomas D Anthopoulos
Fullerenes and their derivatives are widely used as electron acceptors in bulk-heterojunction organic solar cells as they combine high electron mobility with good solubility and miscibility with relevant semiconducting polymers. However, studies on the use of fullerenes as the sole photogeneration and charge-carrier material are scarce. Here, a new type of solution-processed small-molecule solar cell based on the two most commonly used methanofullerenes, namely [6,6]-phenyl-C61-butyric acid methyl ester (PC60 BM) and [6,6]-phenyl-C71-butyric acid methyl ester (PC70 BM), as the light absorbing materials, is reported...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29715665/unsaturated-fat-fraction-from-lard-increases-the-oxidative-stability-of-minced-pork
#20
Miao Liu, Anna-Maija Lampi, Per Ertbjerg
Lard from pork back fat was dry fractionated based on crystallization temperature, resulting in fractions with a ratio of saturated to unsaturated fatty acids of 1.10 and 0.61. Lean minced pork was mixed with the saturated and unsaturated fat fraction and stored in modified atmosphere (80% O2 and 20% CO2 ) at 5 °C for 2, 5, 7, 9, and 12 days under light to investigate the effect on oxidative stability of lipids and proteins. The saturated fat group developed higher TBARS values and lower levels of free thiol groups during storage, indicating that the unsaturated fat fraction in minced pork promoted increased oxidative stability of both lipids and proteins...
April 25, 2018: Meat Science
keyword
keyword
42425
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"