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https://www.readbyqxmd.com/read/29674598/online-monitoring-of-carbon-dioxide-and-oxygen-in-exhaled-mouse-breath-via-substrate-integrated-hollow-waveguide-fourier-transform-infrared-luminescence-spectroscopy
#1
Felicia Seichter, Erhan Tuetuencue, Tamina Hagemann, Josef Vogt, Ulrich Wachter, Michael Groeger, Sandra Kress, Peter Radermacher, Boris Mizaikoff
Exhaled breath offers monitoring bio markers, as well as diagnosing diseases and therapeutic interventions. In addition, vital functions may be non-invasively monitored on-line. Animal models are frequently used in research for determining novel therapeutic approaches and/or for investigating biological pathways. The exhaled carbon dioxide concentration, exhaled and inhaled oxygen concentration, and the subsequent respiratory quotient (RQ) offer insight into metabolic activity. One may adapt breath sampling systems and equipment designed for human applications to large animal studies, however, such adaptations are usually impossible for small animals due to their minuscule breath volume...
April 20, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29669430/providing-palliative-care-in-the-medical-icu-a-qualitative-study-of-micu-physicians-beliefs-and-practices
#2
Brittany Gatta, Jessica Turnbull
CONTEXT: With the current and projected shortage of palliative care (PC) specialists, an integrative model of PC will be needed to meet the needs of patients in intensive care units (ICUs). Prior studies of PC interventions suggest that success depends upon meeting the needs of individual institutions or ICUs. OBJECTIVE: The objective of this study was to qualitatively explore the beliefs and practices of one institution's medical ICU (MICU) physicians in regard to providing an integrative model of PC...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29662667/genetically-enhanced-t-lymphocytes-and-the-intensive-care-unit
#3
REVIEW
Tiberiu Tat, Huming Li, Catalin-Sorin Constantinescu, Anca Onaciu, Sergiu Chira, Ciprian Osan, Sergiu Pasca, Bobe Petrushev, Vlad Moisoiu, Wilhelm-Thomas Micu, Cristian Berce, Sebastian Tranca, Delia Dima, Ioana Berindan-Neagoe, Jianliang Shen, Ciprian Tomuleasa, Liren Qian
Chimeric antigen receptor-modified T cells (CAR-T cells) and donor lymphocyte infusion (DLI) are important protocols in lymphocyte engineering. CAR-T cells have emerged as a new modality for cancer immunotherapy due to their potential efficacy against hematological malignancies. These genetically modified receptors contain an antigen-binding moiety, a hinge region, a transmembrane domain, and an intracellular costimulatory domain resulting in lymphocyte T cell activation subsequent to antigen binding. In present-day medicine, four generations of CAR-T cells are described depending on the intracellular signaling domain number of T cell receptors...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29644052/environmental-colonization-and-onward-clonal-transmission-of-carbapenem-resistant-acinetobacter-baumannii-crab-in-a-medical-intensive-care-unit-the-case-for-environmental-hygiene
#4
Deborah H L Ng, Kalisvar Marimuthu, Jia Jun Lee, Wei Xin Khong, Oon Tek Ng, Wei Zhang, Bee Fong Poh, Pooja Rao, Maya Devi Rajinder Raj, Brenda Ang, Partha Pratim De
Background: In May 2015, we noticed an increase in carbapenem-resistant Acinetobacter baumannii (CRAB) infections in the Medical Intensive Care Unit (MICU). To investigate this, we studied the extent of environmental contamination and subsequent onward clonal transmission of CRAB. Methods: We conducted a one-day point prevalence screening (PPS) of the patients and environment in the MICU. We screened patients using endotracheal tube aspirates and swabs from nares, axillae, groin, rectum, wounds, and exit sites of drains...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29607161/effectiveness-of-high-flow-nasal-cannula-oxygen-therapy-for-acute-respiratory-failure-with-hypercapnia
#5
Eun Sun Kim, Hongyeul Lee, Se Joong Kim, Jisoo Park, Yeon Joo Lee, Jong Sun Park, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young-Jae Cho
Background: Heated and humidified high-flow nasal cannula (HFNC) oxygen therapy has recently been introduced for hypoxic respiratory failure. However, it has not been well-evaluated for acute respiratory failure with hypercapnia. Methods: This retrospective study included acute respiratory failure patients with hypercapnia in the medical intensive care unit (MICU) from April 2011 to February 2013, who required HFNC oxygen therapy for hypoxemia. Respiratory parameters were recorded and arterial blood gas analyses conducted before, and at 1 and 24 h after initiation of HFNC oxygen therapy...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29562815/super-obesity-in-the-medical-intensive-care-unit
#6
Santhi Iyer Kumar, Kathleen Doo, Julie Sottilo-Brammeier, Christianne Lane, Janice M Liebler
BACKGROUND: Studies exploring the effect of body mass index (BMI) on outcomes in the intensive care unit (ICU) have yielded mixed results, with few studies assessing patients at the extremes of obesity. We sought to understand the clinical characteristics and outcomes of patients with super obesity (BMI > 50 kg/m2 ) as compared to morbid obesity (BMI > 40 kg/m2 ) and obesity (BMI > 30 kg/m2 ). METHODS: A retrospective review of patients admitted to the Los Angeles County + University of Southern California medical intensive care unit (MICU) service between 2008 and 2013 was performed...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29560736/evaluating-vasopressor-discontinuation-strategies-in-patients-with-septic-shock-on-concomitant-norepinephrine-and-vasopressin-infusions
#7
Nadine Musallam, Diana Altshuler, Cristian Merchan, Bishoy Zakhary, Caitlin Aberle, John Papadopoulos
BACKGROUND: There is little data guiding clinicians on how to discontinue vasopressors among septic shock patients on concomitant norepinephrine (NE) and vasopressin (VP). OBJECTIVE: To determine the incidence of hypotension within 24 hours of discontinuing NE (NE DC first) versus VP (VP DC first) first in septic shock patients. METHODS: This retrospective study evaluated septic shock patients admitted to the medical intensive care unit (MICU) and surgical ICU (SICU) receiving concomitant NE and VP...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29541446/reducing-health-care-associated-infections-by-implementing-separated-environmental-cleaning-management-measures-by-using-disposable-wipes-of-four-colors
#8
Swee Siang Wong, Cheng Hua Huang, Chiu Chu Yang, Yi Pei Hsieh, Chen Ni Kuo, Yi Ru Chen, Li Ching Chen
Background: Environmental cleaning is a fundamental principle of infection control in health care settings. We determined whether implementing separated environmental cleaning management measures in MICU reduced the density of HAI. Methods: We performed a 4-month prospective cohort intervention study between August and December 2013, at the MICU of Cathay General hospital. We arranged a training program for all the cleaning staff regarding separated environmental cleaning management measures by using disposable wipes of four colors to clean the patients' bedside areas, areas at a high risk of contamination, paperwork areas, and public areas...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29535120/identification-of-calcium-pyrophosphate-deposition-disease-cppd-by-ultrasound-reliability-of-the-omeract-definitions-in-an-extended-set-of-joints-an-international-multiobserver-study-by-the-omeract-calcium-pyrophosphate-deposition-disease-ultrasound-subtask
#9
Georgios Filippou, Carlo Alberto Scirè, Antonella Adinolfi, Nemanja S Damjanov, Greta Carrara, George A W Bruyn, Tomas Cazenave, Maria Antonietta D'Agostino, Andrea Delle Sedie, Valentina Di Sabatino, Mario Enrique Diaz Cortes, Emilio Filippucci, Frederique Gandjbakhch, Marwin Gutierrez, Daryl K Maccarter, Mihaela Micu, Ingrid Möller Parera, Gaël Mouterde, Mohamed Atia Mortada, Esperanza Naredo, Carlos Pineda, Francesco Porta, Anthony M Reginato, Iulia Satulu, Wolfgang A Schmidt, Teodora Serban, Lene Terslev, Violeta Vlad, Florentin Ananu Vreju, Pascal Zufferey, Panagiotis Bozios, Carmela Toscano, Valentina Picerno, Annamaria Iagnocco
OBJECTIVES: To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS: A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD...
March 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29522709/lactate-poct-in-mobile-intensive-care-units-for-septic-patients-a-comparison-of-capillary-blood-method-versus-venous-blood-and-plasma-based-reference-methods
#10
Teddy Léguillier, Romain Jouffroy, Marie Boisson, Agathe Boussaroque, Camille Chenevier-Gobeaux, Tarek Chaabouni, Benoît Vivien, Valérie Nivet-Antoine, Jean-Louis Beaudeux
AIM OF THE STUDY: We evaluated if the StatStrip Xpress Meter, a Lactate point of care testing (POCT) handled device, could be a valuable tool in the mobile intensive care units (MICU) to assess the severity of septic patients. METHODS: We first investigated POCT analytical performance, then, using samples collected from 50 identified septic patients admitted to the intensive care unit (ICU), we compared lactate values obtained with the device to those obtained with four central laboratory analysers: one whole blood and three plasma-based methods...
March 6, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29518848/-acute-respiratory-failure-due-to-pneumocystis-pneumonia-in-connective-tissue-disease-patients-clinical-manifestation-and-prognostic-factors-related-to-hospital-mortality
#11
X Huang, L Weng, L Yi, M Li, Y Y Feng, Y Tian, J G Xia, Q Y Zhan, B Du
Objective: To investigate the clinical manifestations and prognostic factors of hospital death in connective tissue disease patients with acute respiratory failure caused by pneumocystis pneumonia (PCP) admitted to two medical intensive care units(MICU). Methods: A retrospective review was conducted for all connective tissue disease (CTD) patients with acute respiratory failure from PCP in MICU of 2 academic medical centers between 2010 and 2015. The patients were divided into survivors and non-survivors. Demographic and clinical data, including laboratory, radiological and microbiological findings, as well as therapy, clinical course, mortality and prognostic factors of hospital mortality were included in the analysis...
March 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29515572/chimeric-antigen-receptor-t-cells-for-the-treatment-of-b-cell-acute-lymphoblastic-leukemia
#12
REVIEW
Ciprian Tomuleasa, Shigeo Fuji, Cristian Berce, Anca Onaciu, Sergiu Chira, Bobe Petrushev, Wilhelm-Thomas Micu, Vlad Moisoiu, Ciprian Osan, Catalin Constantinescu, Sergiu Pasca, Ancuta Jurj, Laura Pop, Ioana Berindan-Neagoe, Delia Dima, Shigehisa Kitano
Chimeric antigen receptor (CAR) T-cell technology has seen a rapid development over the last decade mostly due to the potential that these cells may have in treating malignant diseases. It is a generally accepted principle that very few therapeutic compounds deliver a clinical response without treatment-related toxicity, and studies have shown that CAR T-cells are not an exception to this rule. While large multinational drug companies are currently investigating the potential role of CAR T-cells in hematological oncology, the potential of such cellular therapies are being recognized worldwide as they are expected to expand in the patient to support the establishment of the immune memory, provide a continuous surveillance to prevent and/or treat a relapse, and keep the targeted malignant cell subpopulation in check...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29502800/paternal-exposure-to-antirheumatic-drugs-what-physicians-should-know-review-of-the-literature
#13
REVIEW
M C Micu, M Ostensen, P M Villiger, R Micu, R Ionescu
Reproduction capacity and long-term preserved hormonal function are important aspects with big impacts on patients' quality of life. Updated information on the interaction between drug therapy and reproductive function is essential when discussing family planning with patients. Currently, limited data is published regarding paternal exposure to different medications. Thus, it may be a challenge for the practitioner to choose the right therapy for a young male patient. Therefore we reviewed the literature, for effects of antirheumatic drugs on male gonadal function with a focus on spermatogenesis and offspring...
January 11, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29453467/loading-dose-only-versus-standard-dose-magnesium-sulfate-seizure-prophylaxis-in-severe-pre-eclamptic-women
#14
Surya Prasad Rimal, Pappu Rijal, Rabindra Bhatt, Kriti Thapa
INTRODUCTION: Magnesium sulfate is the drug of choice for prevention of seizures in the pre-eclamptic woman. There is no agreement in the published randomized trials regarding the optimal time to initiate magnesium sulfate, the dose to use (both loading and maintenance) as well as the duration of therapy. The objective of this study is to determine whether magnesium sulfate prophylaxis is needed for up to 24 hours postpartum in all patients with severe pre-eclampsia for the prevention of seizure...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29426497/detection-and-scavenging-of-hydroxyl-radical-via-d-phenylalanine-hydroxylation-in-human-fluids
#15
Roberto Biondi, Stefano Brancorsini, Giulia Poli, Maria Giulia Egidi, Enrico Capodicasa, Livio Bottiglieri, Sandro Gerli, Eleonora Brillo, Gian Carlo Di Renzo, Dragos Cretoiu, Romeo Micu, Nicolae Suciu
Hydroxyl radical (.OH) is highly reactive, and therefore very short-lived. Finding new means to accurately detect .OH, and testing the ability of known .OH scavengers to neutralize them in human biological fluids would leverage our ability to more effectively counter oxidative (.OH) stress-mediated damage in human diseases. To achieve this, we pursued the evaluation of secondary products resulting from .OH attack, using a detection system based on Fenton reaction-mediated D-phenylalanine (D-Phe) hydroxylation...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29403294/timing-of-antibiotic-administration-and-lactate-measurement-in-septic-shock-patients-a-comparison-between-hospital-wards-and-the-emergency-department
#16
Veerapong Vattanavanit, Theerapat Buppodom, Bodin Khwannimit
Background: The timing of intravenous antibiotic administration and lactate measurement is associated with survival of septic shock patients. Septic shock patients were admitted to the medical intensive care unit (MICU) from 2 major sources: hospital ward and emergency department (ED). This study aimed to compare the timing of antibiotic administration and lactate measurement between hospital wards and the ED. Patients and methods: Medical data were collected from adult patients admitted to the MICU with septic shock from January 2015 to December 2016...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29400374/the-role-of-4d-us-in-evaluation-of-fetal-movements-and-facial-expressions-and-their-relationship-with-fetal-neurobehaviour
#17
REVIEW
Mihaela Grigore, Dumitru Gafitanu, Demetra Socolov, AnaMaria Grigore, Georgiana Nemeti, Romeo Micu
The introduction of four-dimensional (4D) ultrasonography (US) allows the study of fetal movements and facial expressions in real time. The possibility of evaluating fetal movements has led to the study of fetal neurobehaviour, which has been for a long period of time a mystery for physicians. The study of fetal activity in utero could differentiate between normal and abnormal behavioural patterns, thus making possible the early recognition of fetal brain impairment. Facial expressions observed with 4D US represent a marker for neurobehaviour and at the same time could enhance fetal-maternal bonding...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29391140/radiation-exposure-in-the-medical-intensive-care-unit-predictors-and-characteristics
#18
Sudhir Krishnan, Ajit Moghekar, Abhijit Duggal, Jagadeesh Yella, Shraddha Narechania, Vidhya Ramachandran, Atul Mehta, Fatima Adhi, Anil Kumar Changarath Vijayan, Xiaozhen Han, Xiaofeng Wang, Frank Dong, Charles Martin, Jorge Guzman
BACKGROUND: Patients admitted to Medical Intensive care unit (MICU) are often subjected to multiple radiological studies. We hypothesized that some, endure radiation dose exposure [Cumulative Effective dose (CED)] in excess of annual Unites states federal occupational health standard limits (CED≥50 mSv) and 5 year cumulative limit (CED≥100 mSv). We also evaluated the correlation of CED with Acute physiology and chronic health evaluation- 3 score (APACHE 3) and other clinical variables...
January 29, 2018: Chest
https://www.readbyqxmd.com/read/29379004/pneumomediastinum-and-pneumothorax-associated-with-herpes-simplex-virus-hsv-pneumonia
#19
Fermín López-Rivera, Xavier Colón Rivera, Hernán A González Monroig, Juan Garcia Puebla
BACKGROUND Pneumonia is one of the most common causes of death from infectious disease in the United States (US). Although most cases of community-acquired pneumonia (CAP) are secondary to bacterial infection, up to one-third of cases are secondary to viral infection, most commonly due to rhinovirus and influenza virus. Pneumonia due to herpes simplex virus (HSV) is rare, and there is limited knowledge of the pathogenesis and clinical complications. This report is of a fatal case of HSV pneumonia associated with bilateral pneumothorax and pneumomediastinum...
January 30, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29328014/-innovation-in-transport-of-critical-care-patients
#20
Q Muijrers, O Thomas
The differentiation of specialist care means that not every hospital can meet specific care requirements. Because of this, frequent transport of critical care patients is necessary. In most circumstances, regular ambulance transport is used, either with or without an accompanying physician. In some cases, a mobile intensive care unit (MICU) can be deployed. However, the MICU is not 24/7 operational in our area and significant waiting times can occur. Additionally, space and resources in a regular ambulance are limited...
2018: Nederlands Tijdschrift Voor Geneeskunde
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