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Gelfand, erwin

Meiqin Wang, Ivana V Yang, Elizabeth J Davidson, Anthony Joetham, Katsuyuki Takeda, Brian P O'Connor, Erwin W Gelfand
BACKGROUND: Regulatory T cells (Tregs) play an essential role in the maintenance of immune homeostasis in allergic diseases. OBJECTIVES: To define the mechanisms underlying induction of tolerance to peanut protein and prevention of the development of peanut allergy. METHODS: High or low doses of peanut extract (PE) were administered to pups every day for 2 weeks prior to peanut sensitization and challenge. Following challenge, symptoms, Treg numbers, FoxP3, Th2, Th17 cytokine and TGFβ expression in mesenteric lymph node (MLN) CD4(+) T cells and in jejunum were monitored...
May 4, 2017: Journal of Allergy and Clinical Immunology
MirHojjat Khorasanizadeh, Mahsa Eskian, Erwin W Gelfand, Nima Rezaei
Corticosteroid-resistant asthmatics, although comprising only a portion of the asthma population, account for most of the morbidity, mortality and economic burden associated with asthma. Moreover, corticosteroids are not effective inhibitors of airway remodeling changes, and their long-term use is associated with debilitating systemic side effects. Therefore, potent and safe novel therapeutic alternatives, targeting basic pathophysiological mechanisms responsible for the severe asthmatic phenotype are urgently needed...
February 14, 2017: Pharmacology & Therapeutics
K D Quinn, M Schedel, Y Nkrumah-Elie, A Joetham, M Armstrong, C Cruickshank-Quinn, R Reisdorph, E W Gelfand, N Reisdorph
BACKGROUND: Asthma is a complex lung disease resulting from the interplay of genetic and environmental factors. To understand the molecular changes that occur during the development of allergic asthma without genetic and environmental confounders, an experimental model of allergic asthma in mice was used. Our goals were to (1) identify changes at the small molecule level due to allergen exposure, (2) determine perturbed pathways due to disease, and (3) determine whether small molecule changes correlate with lung function...
February 18, 2017: Allergy
Anthony Joetham, Michaela Schedel, Brian P O'Connor, Soohyun Kim, Katsuyuki Takeda, Jordan Abbott, Erwin W Gelfand
BACKGROUND: Regulatory T cells attenuate development of asthma in wild-type (WT) mice, with both naturally occurring regulatory T (nTreg) cells and inducible regulatory T (iTreg) cells exhibiting suppressive activity. When transferred into CD8-deficient (CD8(-/-)) recipients, both cell types enhanced development of allergen-induced airway hyperresponsiveness. OBJECTIVE: We sought to determine whether the pathways leading to enhancement of lung allergic responses by transferred nTreg and iTreg cells differed...
April 2017: Journal of Allergy and Clinical Immunology
Azzeddine Dakhama, Erwin W Gelfand
This chapter describes two procedures commonly used to examine airway function in mice. Airway function can be assessed in vivo using noninvasive or invasive methods. Noninvasive methods can be used to monitor respiratory function in mice without the involvement of restraint, anesthesia, or surgery. The methods allow for multiple animals to be monitored simultaneously and can be used in longitudinal studies requiring repeated measurements on the same animals. Invasive methods are used to assess airway function under anesthesia, in mechanically ventilated mice...
2016: Methods in Molecular Biology
Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Koichi Waseda, Daisuke Morichika, Etsuko Kurimoto, Hikari Koga, Mikio Kataoka, Erwin W Gelfand, Daniel J Cua, Akihiko Yoshimura, Mitsune Tanimoto, Arihiko Kanehiro
We recently reported that IL-17A plays a critical role in the development of porcine pancreatic elastase (PPE)-induced emphysema. The proliferation of T helper 17 (Th17) cells was induced by IL-23. To determine the contribution of IL-23 to the development of pulmonary emphysema a mouse model of PPE-induced emphysema was used in which responses of IL-23p19-deficient (IL-23-/-) and wild type (WT) mice were compared. Intra-tracheal instillation of PPE induced emphysematous changes in the lungs and was associated with increased levels of IL-23 in lung homogenates...
June 28, 2016: American Journal of Respiratory Cell and Molecular Biology
Katsuyuki Takeda, Nobuaki Miyahara, Shigeki Matsubara, Christian Taube, Kenichi Kitamura, Astushi Hirano, Mitsune Tanimoto, Erwin W Gelfand
Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge...
June 2016: Immune Network
M Wang, J Han, J Domenico, Y S Shin, Y Jia, E W Gelfand
BACKGROUND: Signaling through histamine receptors on dendritic cells (DCs) may be involved in the effector phase of peanut-induced intestinal anaphylaxis. OBJECTIVES: The objective of this study was to determine the role of histamine H1 (H1R) and H4 receptors (H4R) in intestinal allergic responses in a model of peanut allergy. METHODS: Balb/c mice were sensitized and challenged with peanut. During the challenge phase, mice were treated orally with the H1R antagonist, loratadine, and/or the H4R antagonist, JNJ7777120...
November 2016: Allergy
Hye Sun Kuehn, Bertrand Boisson, Charlotte Cunningham-Rundles, Janine Reichenbach, Asbjørg Stray-Pedersen, Erwin W Gelfand, Patrick Maffucci, Keith R Pierce, Jordan K Abbott, Karl V Voelkerding, Sarah T South, Nancy H Augustine, Jeana S Bush, William K Dolen, Betty B Wray, Yuval Itan, Aurelie Cobat, Hanne Sørmo Sorte, Sundar Ganesan, Seraina Prader, Thomas B Martins, Monica G Lawrence, Jordan S Orange, Katherine R Calvo, Julie E Niemela, Jean-Laurent Casanova, Thomas A Fleisher, Harry R Hill, Attila Kumánovics, Mary Ellen Conley, Sergio D Rosenzweig
BACKGROUND: Common variable immunodeficiency (CVID) is characterized by late-onset hypogammaglobulinemia in the absence of predisposing factors. The genetic cause is unknown in the majority of cases, and less than 10% of patients have a family history of the disease. Most patients have normal numbers of B cells but lack plasma cells. METHODS: We used whole-exome sequencing and array-based comparative genomic hybridization to evaluate a subset of patients with CVID and low B-cell numbers...
March 17, 2016: New England Journal of Medicine
Akihiko Taniguchi, Nobuaki Miyahara, Koichi Waseda, Etsuko Kurimoto, Utako Fujii, Yasushi Tanimoto, Mikio Kataoka, Yasuhiko Yamamoto, Erwin W Gelfand, Hiroshi Yamamoto, Mitsune Tanimoto, Arihiko Kanehiro
The receptor for advanced glycation end-products (RAGE) is a multiligand receptor that belongs to the immunoglobulin superfamily. RAGE is reported to be involved in various inflammatory disorders; however, studies that address the role of RAGE in allergic airway disease are inconclusive. RAGE-sufficient (RAGE+/+) and RAGE-deficient (RAGE-/-) mice were sensitized to ovalbumin, and airway responses were monitored after ovalbumin challenge. RAGE-/- mice showed reduced eosinophilic inflammation and goblet cell metaplasia, lower T helper type 2 (Th2) cytokine production from spleen and peribronchial lymph node mononuclear cells, and lower numbers of group 2 innate lymphoid cells in the lung compared with RAGE+/+ mice following sensitization and challenge...
October 15, 2015: American Journal of Physiology. Lung Cellular and Molecular Physiology
Christiana Smith, Cullen Dutmer, D Scott Schmid, Megan K Dishop, William J Bellini, Erwin W Gelfand, Edwin J Asturias
No abstract text is available yet for this article.
December 2015: Journal of the Pediatric Infectious Diseases Society
Lisa J Meltzer, Anna Faino, Stanley J Szefler, Matthew Strand, Erwin W Gelfand, Dean W Beebe
OBJECTIVE: To examine the impact of sleep duration on lung function and asthma symptoms in adolescents. METHODS: Ten adolescents with asthma (60% female, 60% Caucasian, mean age = 13.7 years, range 12-17) completed a 3-week randomized, cross-over sleep manipulation protocol. Following a week of self-selected sleep duration, adolescents were randomized to a five-night deficient sleep opportunity (6.5 hr in bed) or a healthy sleep opportunity (10 hr in bed) obtained by systematically changing bedtimes...
December 2015: Pediatric Pulmonology
Erwin W Gelfand, Rafeul Alam
No abstract text is available yet for this article.
May 2015: Journal of Allergy and Clinical Immunology
Katsuyuki Takeda, Yoshiki Shiraishi, Shigeru Ashino, Junyan Han, Yi Jia, Meiqin Wang, Nancy A Lee, James J Lee, Erwin W Gelfand
BACKGROUND: Eosinophils accumulate at the site of allergic inflammation and are critical effector cells in allergic diseases. Recent studies have also suggested a role for eosinophils in the resolution of inflammation. OBJECTIVE: To determine the role of eosinophils in the resolution phase of the response to repeated allergen challenge. METHODS: Eosinophil-deficient (PHIL) and wild-type (WT) littermates were sensitized and challenged to ovalbumin (OVA) 7 or 11 times...
February 2015: Journal of Allergy and Clinical Immunology
Koichi Waseda, Nobuaki Miyahara, Akihiko Taniguchi, Etsuko Kurimoto, Genyo Ikeda, Hikari Koga, Utako Fujii, Yasuhiko Yamamoto, Erwin W Gelfand, Hiroshi Yamamoto, Mitsune Tanimoto, Arihiko Kanehiro
Pulmonary emphysema is characterized by persistent inflammation and progressive alveolar destruction. The receptor for advanced glycation end-products (RAGE) is a multiligand cell surface receptor reported to be involved in the process of acute alveolar epithelial cell injury. However, studies that address the role of RAGE in pulmonary emphysema are inconclusive. We investigated the role of RAGE in the development of elastase-induced pulmonary inflammation and emphysema in mice. RAGE-sufficient (RAGE(+/+)) mice and RAGE-deficient (RAGE(-/-)) mice were treated with intratracheal elastase on Day 0...
April 2015: American Journal of Respiratory Cell and Molecular Biology
Antonia Kwan, Roshini S Abraham, Robert Currier, Amy Brower, Karen Andruszewski, Jordan K Abbott, Mei Baker, Mark Ballow, Louis E Bartoshesky, Francisco A Bonilla, Charles Brokopp, Edward Brooks, Michele Caggana, Jocelyn Celestin, Joseph A Church, Anne Marie Comeau, James A Connelly, Morton J Cowan, Charlotte Cunningham-Rundles, Trivikram Dasu, Nina Dave, Maria T De La Morena, Ulrich Duffner, Chin-To Fong, Lisa Forbes, Debra Freedenberg, Erwin W Gelfand, Jaime E Hale, I Celine Hanson, Beverly N Hay, Diana Hu, Anthony Infante, Daisy Johnson, Neena Kapoor, Denise M Kay, Donald B Kohn, Rachel Lee, Heather Lehman, Zhili Lin, Fred Lorey, Aly Abdel-Mageed, Adrienne Manning, Sean McGhee, Theodore B Moore, Stanley J Naides, Luigi D Notarangelo, Jordan S Orange, Sung-Yun Pai, Matthew Porteus, Ray Rodriguez, Neil Romberg, John Routes, Mary Ruehle, Arye Rubenstein, Carlos A Saavedra-Matiz, Ginger Scott, Patricia M Scott, Elizabeth Secord, Christine Seroogy, William T Shearer, Subhadra Siegel, Stacy K Silvers, E Richard Stiehm, Robert W Sugerman, John L Sullivan, Susan Tanksley, Millard L Tierce, James Verbsky, Beth Vogel, Rosalyn Walker, Kelly Walkovich, Jolan E Walter, Richard L Wasserman, Michael S Watson, Geoffrey A Weinberg, Leonard B Weiner, Heather Wood, Anne B Yates, Jennifer M Puck, Vincent R Bonagura
IMPORTANCE: Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and SCID was added to the national recommended uniform panel for newborn screened disorders in 2010. Currently 23 states, the District of Columbia, and the Navajo Nation conduct population-wide newborn screening for SCID. The incidence of SCID is estimated at 1 in 100,000 births. OBJECTIVES: To present data from a spectrum of SCID newborn screening programs, establish population-based incidence for SCID and other conditions with T-cell lymphopenia, and document early institution of effective treatments...
August 20, 2014: JAMA: the Journal of the American Medical Association
Anthony Joetham, Michaela Schedel, Katsuyuki Takeda, Yi Jia, Shigeru Ashino, Azzeddine Dakhama, Anna Lluis, Masakazu Okamoto, Erwin W Gelfand
Glucocorticoid-induced TNFR family-related protein (GITR)-mediated activation of JNK was shown to regulate the suppressive activity of CD4(+)CD25(+) naturally occurring T regulatory cells (nTregs) in wild-type (WT) hosts. In this study, CD4(+)CD25(+) T cells were shown to be capable of becoming pathogenic effector cells in sensitized and challenged CD8(-/-) recipient mice. Only GITR-expressing CD4(+)CD25(+) T cells, but neither GITR knocked-in CD4(+)CD25(-) T cells nor GITR-silenced CD4(+)CD25(+) T cells, enhanced development of lung allergic responses...
September 1, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
Yi Jia, Joanne Domenico, Christina Swasey, Meiqin Wang, Erwin W Gelfand, Joseph J Lucas
G1-phase cell cycle defects, such as alterations in cyclin D1 or cyclin-dependent kinase (cdk) levels, are seen in most tumors. For example, increased cyclin D1 and decreased cdk6 levels are seen in many human breast tumors. Overexpression of cdk6 in breast tumor cells in culture has been shown to suppress proliferation, unlike the growth stimulating effects of its close homolog, cdk4. In addition to directly affecting proliferation, alterations in cdk6 or cdk4 levels in breast tumor cells also differentially influence levels of numerous steroid metabolic enzymes (SMEs), including those involved in estrogen metabolism...
2014: PloS One
Sang-Ha Kim, E Rand Sutherland, Erwin W Gelfand
Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible that shared inflammatory mechanisms play a role in determining this linkage. Although controversial, the role of adipokines may be central to this association and the maintenance of the asthma phenotype. While leptin and adiponectin have a causal link to experimental asthma in mice, data in humans are less conclusive. Recent studies demonstrate that adipokines can regulate the survival and function of eosinophils and that these factors can affect eosinophil trafficking from the bone marrow to the airways...
May 2014: Allergy, Asthma & Immunology Research
Huie Jing, Qian Zhang, Yu Zhang, Brenna J Hill, Christopher G Dove, Erwin W Gelfand, T Prescott Atkinson, Gulbu Uzel, Helen F Matthews, Peter J Mustillo, David B Lewis, Fotini D Kavadas, I Celine Hanson, Ashish R Kumar, Raif S Geha, Daniel C Douek, Steven M Holland, Alexandra F Freeman, Helen C Su
BACKGROUND: Autosomal recessive loss-of-function mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency characterized by atopy, recurrent infections, and cancer susceptibility. A genotype-phenotype explanation for the variable disease expression is lacking. OBJECTIVE: We investigated whether reversions contributed to the variable disease expression. METHODS: Patients followed at the National Institutes of Health's Clinical Center were studied...
June 2014: Journal of Allergy and Clinical Immunology
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