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https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#1
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29221616/dengue-fever-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#2
REVIEW
Pravin Amin, Özlem Acicbe, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Tim Baker, Guy A Richards
Dengue is an arbovirus affecting humans and spread by mosquitoes. Severe dengue follows a secondary infection with a different virus serotype. The problem is truly global as it is endemic in over 100 countries. Severe dengue can be a life-threatening because of increased vascular permeability, resulting in leakage of fluid from the intravascular compartment to the extravascular space. When major bleeding does occur, it is almost invariably combined with profound shock since this, in combination with thrombocytopenia, hypoxia, and acidosis, can lead to multiple organ failure and disseminated intravascular coagulation...
November 5, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29215033/transplantation-of-a-quaternary-structure-neutralizing-antibody-epitope-from-dengue-virus-serotype-3-into-serotype-4
#3
Douglas G Widman, Ellen Young, Usha Nivarthi, Jesica A Swanstrom, Scott R Royal, Boyd L Yount, Kari Debbink, Matthew Begley, Stephanie Marcet, Anna Durbin, Aravinda M de Silva, William B Messer, Ralph S Baric
Dengue vaccine trials have revealed deficits in our understanding of the mechanisms of protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for neutralization. Structure guided design and reverse genetics were used to sequentially transplant larger portions of the DENV3-specific 5J7 mAb epitope into dengue virus serotype 4 (DENV4)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211630/production-of-monoclonal-antibody-that-recognizes-zika-virus-and-other-flaviviruses-in-serum-free-conditions
#4
Fernando de Paiva Conte, Raquel de Souza Martins, Ana Carolina Dos Reis Albuquerque Cajaraville, Hilton Jorge Nascimento, Patricia Barbosa Jurgilas, Sheila Maria Barbosa de Lima, Sotiris Missailidis, Márcia Arissawa
With the recent outbreaks of Zika and Dengue virus infections in various countries worldwide, production of vaccines or diagnostic kits is an urgent public health demand. Production of a monoclonal antibody (mAb) that specifically binds to a common antigen shared by the Flavivirus genus will be necessary for new diagnostic kits or characterization and viral identity tests during vaccine development. This study aimed to cultivate, in serum-free conditions, the 4G2 hybridoma that produces an mAb, which recognizes a shared epitope from the Flavivirus genus...
December 6, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29200948/peptides-as-therapeutic-agents-for-dengue-virus
#5
REVIEW
Miaw-Fang Chew, Keat-Seong Poh, Chit-Laa Poh
Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29194547/neutralizing-antibody-correlates-analysis-of-tetravalent-dengue-vaccine-efficacy-trials-in-asia-and-latin-america
#6
Zoe Moodie, Michal Juraska, Ying Huang, Yingying Zhuang, Youyi Fong, Lindsay N Carpp, Steven G Self, Laurent Chambonneau, Robert Small, Nicholas Jackson, Fernando Noriega, Peter B Gilbert
Background: In the CYD14 and CYD15 Phase 3 trials of the CYD-TDV dengue vaccine, estimated vaccine efficacy (VE) against symptomatic, virologically-confirmed dengue (VCD) occurring between Months 13 and 25 was 56.5% and 60.8%, respectively. Methods: Neutralizing antibody titers to the four dengue serotypes in the CYD-TDV vaccine insert were measured at Month 13 in a randomly sampled immunogenicity sub-cohort and in all VCD cases through Month 25 (2848 vaccine, 1574 placebo) and studied for their association with VCD and with the level of VE to prevent VCD...
November 29, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29193604/first-insights-on-insecticidal-activity-upon-aedes-aegypti-and-partial-biochemical-characterization-of-a-novel-low-molecular-mass-chymotrypsin-trypsin-inhibitor-purified-from-lonchocarpus-sericeus-seeds
#7
Luiz C P Almeida Filho, Pedro M S Tabosa, Denise C Hissa, Ilka M Vasconcelos, Ana F U Carvalho
BACKGROUND: Arboviroses such as dengue, zika and chikungunya represent a serious issue in public health due to the absence of approved vaccine or specific antiviral drugs. One way to prevent these diseases is by combating the vector mosquito, Aedes aegypti (Diptera), which has serine proteases in the midgut. Protease inhibitors are molecules that can block enzyme activity impairing digestion and nutrition that can lead to death. Thus, we purified and characterized a novel chymotrypsin- trypsin inhibitor from Lonchocarpus sericeus (LsCTI) seeds and investigated its effect upon Ae...
November 28, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29186193/rig-i-like-receptor-activation-by-dengue-virus-drives-follicular-t-helper-cell-formation-and-antibody-production
#8
Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek
Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here show that dengue virus (DENV) infection of human dendritic cells (DCs) drives TFH formation via crosstalk of RIG-I-like receptor (RLR) RIG-I and MDA5 with type I Interferon (IFN) signaling. DENV infection leads to RLR-dependent IKKε activation, which phosphorylates IFNα/β receptor-induced STAT1 to drive IL-27 production via the transcriptional complex ISGF3...
November 29, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29183717/using-wolbachia-for-dengue-control-insights-from-modelling
#9
REVIEW
Ilaria Dorigatti, Clare McCormack, Gemma Nedjati-Gilani, Neil M Ferguson
Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector-control programmes have limited effectiveness, and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia, deliberately introduced into Aedes aegyptimosquitoes, have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence...
November 25, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29181956/infectious-diseases-in-poland-in-2015
#10
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P. Czarkowski
PURPOSE OF THE STUDY: This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiological Review. Its purpose is to identify potential threats to the health of populations from infectious diseases occurring in Poland with reference to other parts of the globe. MATERIAL AND METHODS: This paper is an introduction to more detailed studies of the epidemiological situation of selected infectious diseases and summarizes the results of the surveillance of infectious diseases in Poland in 2015...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29180056/review-of-a-licensed-dengue-vaccine-inappropriate-subgroup-analyses-and-selective-reporting-may-cause-harm-in-mass-vaccination-programs
#11
Antonio L Dans, Leonila F Dans, Mary Ann D Lansang, Maria Asuncion A Silvestre, Gordon H Guyatt
Severe life-threatening dengue fever usually occurs when a child is infected by dengue virus a 2nd time. This is caused by a phenomenon called antibody dependent enhancement or ADE. Since dengue vaccines can mimic a first infection in seronegative children (those with no previous infection), a natural infection later in life could lead to severe disease. The possibility that dengue vaccines can cause severe dengue through ADE has led to serious concern regarding the safety of mass vaccination programs. A published meta-analysis addressed this safety issue for a new vaccine against dengue fever - Dengvaxia ™...
November 24, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29178115/multiplex-polymerase-chain-reaction-based-serotype-analysis-of-dengue-virus-during-2015-dengue-outbreak-in-pakistan
#12
Eijaz Ghani, Saadiya Mushtaq, Saleem A Khan
Dengue is one of the most important arthropod-borne viral diseases. It is endemic in > 125 countries including Pakistan, with a global incidence of 50-200 million. We determined the frequency of different serotypes of dengue virus to highlight its hyperendemicity in Rawalpindi, Pakistan. Between May and October 2015 we analysed the serum samples of 140 patients with a suspicion of dengue, using ELISA and multiplex polymerase chain reaction. One hundred and eight were infected with serotype 2, 16 with serotype 3, 7 with serotype 4 and 3 with serotype 1...
November 19, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29176643/development-of-a-quantitative-ns1-capture-enzyme-linked-immunosorbent-assay-for-early-detection-of-yellow-fever-virus-infection
#13
Taissa Ricciardi-Jorge, Juliano Bordignon, Andrea Koishi, Camila Zanluca, Ana Luiza Mosimann, Claudia Nunes Duarte Dos Santos
Yellow fever is an arboviral disease that causes thousands of deaths every year in Africa and the Americas. However, few commercial diagnostic kits are available. Non-structural protein 1 (NS1) is an early marker of several flavivirus infections and is widely used to diagnose dengue virus (DENV) infection. Nonetheless, little is known about the dynamics of Yellow fever virus (YFV) NS1 expression and secretion, to encourage its use in diagnosis. To tackle this issue, we developed a quantitative NS1-capture ELISA specific for YFV using a monoclonal antibody and recombinant NS1 protein...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29175781/in-silico-identification-and-evaluation-of-plant-flavonoids-as-dengue-ns2b-ns3-protease-inhibitors-using-molecular-docking-and-simulation-approach
#14
Muhammad Tahirul Qamar, Usman Ali Ashfaq, Kishver Tusleem, Arooj Mumtaz, Quratulain Tariq, Alina Goheer, Bilal Ahmed
Dengue infection is prevailing among the people not only from the developing countries but also from the developed countries due to its high morbidity rate around the globe. Hence, due to the unavailability of any suitable vaccine for rigorous dengue virus (DENV), the only mode of its treatment is prevention. The circumstances require an urgent development of efficient and practical treatment to deal with these serotypes. The severe effects and cost of synthetic vaccines simulated researchers to find anti-viral agents from medicinal plants...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29175328/construction-of-a-high-yield-dengue-virus-by-replacing-nonstructural-proteins-3-4b-without-increasing-virulence
#15
Supranee Phanthanawiboon, Sabar Pambudi, Magot Diata Omokoko, Keiko Hanabara, Atchareeya A-Nuegoonpipat, Wataru Kamitani, Kazuyoshi Ikuta, Takeshi Kurosu
Producing virus at high yield is critically important for development of whole virion inactivated vaccines or live attenuated vaccines. Most dengue virus (DENV) clinical isolates, however, replicate at low levels in cultured cells, which limits their use for vaccine development. The present study examined differences between low-replicating DENV clinical isolates and high-replicating laboratory strains with the aim of engineering high-yield DENV clinical isolates. Construction of a series of recombinant chimeric viruses derived from a high-replicating laboratory DENV type 4 (DENV-4) H241 strain and a clinical isolate revealed that the NS3-NS4B region of H241 conferred a replication advantage in cultured cells...
November 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29169357/in-silico-design-of-a-zika-virus-non-structural-protein-5-aiming-vaccine-protection-against-zika-and-dengue-in-different-human-populations
#16
Lorrany Dos Santos Franco, Paloma Oliveira Vidal, Jaime Henrique Amorim
BACKGROUND: The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enhances ZIKV replication in vitro, which may lead to more severe forms of the disease. Thus, traditional approaches of vaccine development aiming to control viral infection through neutralizing antibodies may induce cross-reactive enhancing antibodies. In contrast, cellular immune response was shown to be capable of controlling DENV infection independently of antibodies...
November 23, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29167334/flow-virometry-a-powerful-tool-to-functionally-characterize-viruses
#17
Roger Lippé
For several decades, flow cytometry has been a common approach to analyze cells and sort them to near purity. It enables one to probe inner cellular molecules, surface receptors or infected cells. However, the analysis of smaller entities such as viruses and exocytic vesicles has been more difficult but is becoming mainstream. This has in part been due to the development of new instrumentation with resolutions below conventional cytometers. It is also attributed to the several means to fluorescently label viruses, hence enabling them to stand out from the similarly sized background noise...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29162320/controlled-human-infections-a-report-from-the-controlled-human-infection-models-workshop-leiden-university-medical-centre-4-6-may-2016
#18
Meta Roestenberg, Annie Mo, Peter G Kremsner, Maria Yazdanbakhsh
The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902) [2]. In these times bioethics and scientific reasoning were in their infancy. Nowadays, clinical trials are highly regulated and CHI are executed worldwide. Controlled human malaria infections and influenza infections are the two most frequently practiced...
November 18, 2017: Vaccine
https://www.readbyqxmd.com/read/29162124/geraniin-extracted-from-the-rind-of-nephelium-lappaceum-binds-to-dengue-virus-type-2-envelope-protein-and-inhibits-early-stage-of-virus-replication
#19
Siti Aisyah Abdul Ahmad, Uma D Palanisamy, Bimo A Tejo, Miaw Fang Chew, Hong Wai Tham, Sharifah Syed Hassan
BACKGROUND: The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin, extracted from the rind of Nephelium lappaceum, against dengue virus type-2 (DENV-2) was investigated. METHODS: Geraniin was prepared from Nephelium lappaceum rind by reverse phase C-18 column chromatography. Cytotoxicity of geraniin towards Vero cells was evaluated using MTT assay while IC50 value was determined by plaque reduction assay...
November 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/29161487/virological-surveillance-of-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-as-support-for-decision-making-for-dengue-control-in-medell%C3%A3-n
#20
Juliana Pérez-Pérez, William H Sanabria, Carolina Restrepo, Raúl Rojo, Enrique Henao, Omar Triana, Ana María Mejía, Sandra M Castaño, Guillermo L Rúa-Uribe
INTRODUCTION: Dengue represents an important public health problem in Colombia. No treatment is available and the vaccine has not been approved in all countries, hence, actions should be strengthened to mitigate its impact through the control of Aedes aegypti, the vector mosquito. In Colombia, surveillance is done using entomological indexes and case notification, which is usually informed late, leading to untimely interventions. Viral detection in urban mosquitoes using molecular techniques provides more accurate entomological information for decision-making...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
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