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https://www.readbyqxmd.com/read/28094237/a-multiplex-microsphere-immunoassay-for-zika-virus-diagnosis
#1
Susan J Wong, Andrea Furuya, Jing Zou, Xuping Xie, Alan P Dupuis, Laura D Kramer, Pei-Yong Shi
Rapid and accurate diagnosis of infectious agents is essential for patient care, disease control, and countermeasure development. The present serologic diagnosis of Zika virus (ZIKV) infection relies mainly on IgM-capture ELISA which is confounded with the flaw of cross-reactivity among different flaviviruses. In this communication, we report a multiplex microsphere immunoassay (MIA) that captures the diagnostic power of viral envelope protein (that elicits robust, yet cross-reactive antibodies to other flaviviruses) and the differential power of viral nonstructural proteins NS1 and NS5 (that induce more virus-type specific antibodies)...
January 10, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28090318/dengue-virus-antibodies-enhance-zika-virus-infection
#2
Lauren M Paul, Eric R Carlin, Meagan M Jenkins, Amanda L Tan, Carolyn M Barcellona, Cindo O Nicholson, Scott F Michael, Sharon Isern
For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases. Recent reports of severe disease associated with ZIKV have greatly heightened awareness. It is anticipated that ZIKV will continue to spread in the Americas and globally where competent Aedes mosquito vectors are found. Dengue virus (DENV), the most common mosquito-transmitted human flavivirus, is both well-established and the source of outbreaks in areas of recent ZIKV introduction...
December 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28077444/protein-interactions-during-the-flavivirus-and-hepacivirus-life-cycle
#3
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann
Protein-protein interactions govern biological functions in cells, in the extracellular milieu and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell. Usage of host proteins by viruses can have severe consequences e.g. apoptosis, metabolic disequilibria or altered cell proliferation and mobility. Understanding protein interactions during virus infection can thus educate us on viral infection and pathogenesis mechanisms...
January 11, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28072887/dengue-fever-in-travellers-and-risk-of-local-spreading-case-reports-from-southern-italy-and-literature-update
#4
Claudia Fabrizio, Luciana Lepore, Maria Chironna, Gioacchino Angarano, Annalisa Saracino
Dengue fever (DF), an arbovirosis caused by Dengue viruses (DV, serotypes 1-4), is responsible for an increasing number of travel-related acute febrile illnesses due to population growth, climate changes, spreading by viremic travellers, and improved laboratory diagnosis. The presence of efficient vectors (mosquito Aedes albopictus) has also been described in temperate regions including Italy which is considered the most heavily infected European country. Normally characterized by non-specific signs and symptoms, DF incidence is probably underestimated, especially in non-endemic countries, but the risk of severe forms is substantial...
January 5, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28067718/immunogenicity-and-safety-of-a-booster-injection-of-dtap-ipv-hib-pentaxim%C3%A2-administered-concomitantly-with-tetravalent-dengue-vaccine-in-healthy-toddlers-aged-15-to-18-months-in-mexico-a-randomized-trial
#5
Flor Irene Rodriguez Melo, José Juan Renteria Morales, Abiel Homero Mascareñas De Los Santos, Enrique Rivas, Claire Vigne, Fernando Noriega
BACKGROUND: The live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in a number of dengue endemic countries for individuals ≥9 years old. Before integration of any vaccine into childhood vaccination schedules, a lack of immune interference and acceptable safety when co-administered with other recommended vaccines should be demonstrated. METHODS: This randomized, multi-center, Phase III trial was conducted in Mexico. Healthy toddlers (n=732) received a booster dose of a licensed pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, inactivated polio vaccine, and Haemophilus influenzae type b [DTaP-IPV//Hib]) either concomitantly or sequentially with the second dose of CYD-TDV administered as a 3-dose schedule...
January 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28035106/zika-virus-infection-past-and-present-of-another-emerging-vector-borne-disease
#6
REVIEW
Hercules Sakkas, Vangelis Economou, Chrissanthy Papadopoulou
Zika virus infection is an emerging mosquito-borne disease, first identified in Uganda in 1947. It is caused by the Zika arbovirus, and transmitted by the bites of infected mosquitoes of the genus Aedes. For almost half a century, the Zika virus was reported as the causative agent of sporadic human infections. In 2007, the Zika virus emerged outside Asia and Africa causing an epidemic on the Island of Yap in Micronesia. The manifestation of the newly acquired human infection varies from asymptomatic to self-limiting acute febrile illness with symptoms and clinical features similar to those caused by the Dengue virus ('Dengue-like syndrome')...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28035105/the-epidemiology-of-dengue-infection-harnessing-past-experience-and-current-knowledge-to-support-implementation-of-future-control-strategies
#7
REVIEW
Narayan Gyawali, Richard S Bradbury, Andrew W Taylor-Robinson
Dengue is the most important mosquito-borne viral infection of humans. Although outbreaks of disease which are now recognized as clinically consistent with dengue have been reported for centuries, it was not until half a century ago that laboratory identification of dengue viruses as the etiological agent of febrile illness was achieved. This debilitating and sometimes fatal disease is widely distributed in >125 countries in tropical and subtropical zones of the world. Asia, South America and the Pacific Islands are hyper-epidemic regions while currently there is less prevalence in Europe, North America and Australia...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28034742/activity-of-andrographolide-against-dengue-virus
#8
Patcharee Panraksa, Suwipa Ramphan, Sarawut Khongwichit, Duncan R Smith
Dengue is the most prevalent arthropod-transmitted viral illness of humans, with an estimated 100 million symptomatic infections occurring each year and more than 2.5 billion people living at risk of infection. There are no approved antiviral agents against dengue virus, and there is only limited introduction of a dengue vaccine in some countries. Andrographolide is derived from Andrographis paniculata, a medicinal plant traditionally used to treat a number of conditions including infections. The antiviral activity of andrographolide against dengue virus (DENV) serotype 2 was evaluated in two cell lines (HepG2 and HeLa) while the activity against DENV 4 was evaluated in one cell line (HepG2)...
December 26, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28031369/mapping-the-human-memory-b-cell-and-serum-neutralizing-antibody-responses-to-denv4-infection-and-vaccination
#9
Usha K Nivarthi, Nurgun Kose, Gopal Sapparapu, Douglas Widman, Emily Gallichotte, Jennifer M Pfaff, Benjamin J Doranz, Daniela Weiskopf, Alessandro Sette, Anna P Durbin, Steve S Whitehead, Ralph Baric, James E Crowe, Aravinda M de Silva
: The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses responsible for dengue fever and dengue hemorrhagic fever. People exposed to DENV develop antibodies that strongly neutralize the serotype responsible for infection. Historically, infection with DENV serotype 4 (DENV4) has been less common and understudied in comparison to the other three serotypes. However, DENV4 has been responsible for recent large and sustained epidemics in Asia and Latin America. The neutralizing antibody responses and the epitopes targeted against DENV4 are not characterized in human infection...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28027002/mathematical-modeling-based-on-ordinary-differential-equations-a-promising-approach-to-vaccinology
#10
Carla Rezende Barbosa Bonin, Guilherme Cortes Fernandes, Rodrigo Weber Dos Santos, Marcelo Lobosco
New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology. One of these areas is computational science, which traditionally participates in the initial steps, such as the pre-screening of active substances that have the potential to become a vaccine antigen. In this work, we present another promising way to use computational science in vaccinology: mathematical and computational models of important cell and protein dynamics of the immune system...
December 27, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28011234/epidemic-arboviral-diseases-priorities-for-research-and-public-health
#11
REVIEW
Annelies Wilder-Smith, Duane J Gubler, Scott C Weaver, Thomas P Monath, David L Heymann, Thomas W Scott
For decades, arboviral diseases were considered to be only minor contributors to global mortality and disability. As a result, low priority was given to arbovirus research investment and related public health infrastructure. The past five decades, however, have seen an unprecedented emergence of epidemic arboviral diseases (notably dengue, chikungunya, yellow fever, and Zika virus disease) resulting from the triad of the modern world: urbanisation, globalisation, and international mobility. The public health emergency of Zika virus, and the threat of global spread of yellow fever, combined with the resurgence of dengue and chikungunya, constitute a wake-up call for governments, academia, funders, and WHO to strengthen programmes and enhance research in aedes-transmitted diseases...
December 20, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28006649/serodiagnosis-of-zika-virus-zikv-infections-by-a-novel-ns1-based-elisa-devoid-of-cross-reactivity-with-dengue-virus-antibodies-a-multicohort-study-of-assay-performance-2015-to-2016
#12
Katja Steinhagen, Christian Probst, Christiane Radzimski, Jonas Schmidt-Chanasit, Petra Emmerich, Marjan van Esbroeck, Janke Schinkel, Martin P Grobusch, Abraham Goorhuis, Jens M Warnecke, Erik Lattwein, Lars Komorowski, Andrea Deerberg, Sandra Saschenbrecker, Winfried Stöcker, Wolfgang Schlumberger
Serological diagnosis of Zika virus (ZIKV) infections is challenging due to high cross-reactivity between flaviviruses. We evaluated the diagnostic performance of a novel anti-ZIKV ELISA based on recombinant ZIKV non-structural protein 1 (NS1). Assay sensitivity was examined using sera from 27 patients with reverse transcription (RT)-PCR-confirmed and 85 with suspected ZIKV infection. Specificity was analysed using sera from 1,015 healthy individuals. Samples from 252 patients with dengue virus (n = 93), West Nile virus (n = 34), Japanese encephalitis virus (n = 25), chikungunya virus (n = 19) or Plasmodium spp...
December 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28003809/cytotoxic-cd4-t-cells-differentiation-function-and-application-to-dengue-virus-infection
#13
REVIEW
Yuan Tian, Alessandro Sette, Daniela Weiskopf
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV infection has not yet been fully successful due to lack of effective therapeutics or vaccines. Nevertheless, a better understanding of the immune responses against DENV infection may reveal new strategies for eliciting and improving antiviral immunity. T cells provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens and memory cells that can survive for long periods with enhanced abilities to control recurring pathogens...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28002420/the-impact-of-the-newly-licensed-dengue-vaccine-in-endemic-countries
#14
Maíra Aguiar, Nico Stollenwerk, Scott B Halstead
BACKGROUND: With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of uncomplicated dengue cases is only supportive and severe dengue cases require hospital intensive care. A vaccine now licensed in several countries and developed by Sanofi Pasteur (CYD-TDV, named Dengvaxia), was able to protect, in the first 25 months of the two Phase III, 66% of a subset of 9-16 year old participants...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27982355/detection-of-human-anti-zika-virus-igg-by-elisa-using-an-antigen-from-in-vitro-infected-vero-cells-preliminary-results
#15
Laura Masami Sumita, Jaqueline Polizeli Rodrigues, Noely Evangelista Ferreira, Alvina Clara Felix, Nathalia Caroline Santiago Souza, Clarisse Martins Machado, Heitor Franco de Andrade Júnior
Zika virus (ZKV) infection is a huge public health problem in Brazil because of the increased incidence of microcephaly in neonates from infected mothers. Detection of specific IgG antibodies in maternal serum samples constitutes an important approach for diagnosing ZKV infection and evaluating its relationship with neonatal microcephaly. However, as there is no serological test produced in Brazil to detect IgM and IgG antibodies against ZKV, we sought to examine specific IgG in serum samples from patients or suspected mothers to detect previous infection and to test for specificity with regard to flaviviral infections occurring in the same area...
December 8, 2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27981613/induction-of-multiple-cytotoxic-t-lymphocyte-responses-in-mice-by-a-multiepitope-dna-vaccine-against-dengue-virus-serotype-1
#16
Xin Yu Chen, De Zhou Li, Xiao Zhi Zhong, Bokun Chen, Zhi Liang Duan, Jin Sheng Wen
Dengue virus (DENV) is still the major threat to the health of humans in most tropical and subtropical countries and regions. In the present study, based on the eukaryotic expressing plasmid pcDNA(TM) 3.1/myc-His(-) A, we constructed a multiepitope DNA vaccine which encodes fifteen immunogenic and conserved HLA-A*0201-, HLA-A*1101-, HLA-A*2402-restricted CTL epitopes from DENV serotype 1 (DENV-1). Immunization of HLA-A*0201 transgenic mice, HLA-A*1101 transgenic mice and HLA-A*2402 transgenic mice with the recombinant plasmid pcDNA(TM) 3...
December 16, 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27974667/molecular-determinants-of-human-neutralizing-antibodies-isolated-from-a-patient-infected-with-zika-virus
#17
Qihui Wang, Huabing Yang, Xiaoqing Liu, Lianpan Dai, Tong Ma, Jianxun Qi, Gary Wong, Ruchao Peng, Sheng Liu, Junfu Li, Shihua Li, Jian Song, Jianying Liu, Jianhua He, Hui Yuan, Ying Xiong, Yong Liao, Jianhua Li, Jianping Yang, Zhou Tong, Bryan D Griffin, Yuhai Bi, Mifang Liang, Xiaoning Xu, Chuan Qin, Gong Cheng, Xinzheng Zhang, Peiyi Wang, Xiangguo Qiu, Gary Kobinger, Yi Shi, Jinghua Yan, George F Gao
The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV...
December 14, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27974563/human-cd4-t-cell-responses-to-an-attenuated-tetravalent-dengue-vaccine-parallel-those-induced-by-natural-infection-in-magnitude-hla-restriction-and-antigen-specificity
#18
Michael A Angelo, Alba Grifoni, Patrick H O'Rourke, John Sidney, Sinu Paul, Bjoern Peters, Aruna D de Silva, Elizabeth Phillips, Simon Mallal, Sean A Diehl, Beth D Kirkpatrick, Stephen S Whitehead, Anna P Durbin, Alessandro Sette, Daniela Weiskopf
: Dengue virus (DENV) is responsible for growing numbers of infections worldwide, and has proven a significant challenge for vaccine development. Previously we demonstrated that CD8(+) T cell responses elicited by a dengue live attenuated vaccine resemble those observed by natural infection. In this study we screen PBMCs from donors vaccinated with a tetravalent live attenuated dengue vaccine (TV005) with pools of dengue virus derived predicted MHC class II binding peptides. The definition of CD4(+) T cell responses after live vaccination is important as CD4(+) T cells are known contributors to host immunity including cytokine production, help for CD8(+) T- and B- cells, and direct cytotoxicity against infected cells...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27973289/the-public-acceptance-and-willingness-to-pay-wtp-of-dengue-vaccine-in-penang-malaysia-assessment-with-a-contingent-valuation-study
#19
H Y Yeo, A A Shafie
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27973274/economic-evaluation-of-dengue-vaccination-in-bangkok-metropolitan-administration
#20
W Liulak, S Chuenkitmongkol, W Thongsri, S Beucher, N Baurin, U Thisyakorn
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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