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https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#1
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29029938/dengvaxia-sensitizes-seronegatives-to-vaccine-enhanced-disease-regardless-of-age
#2
Scott B Halstead
During a large scale clinical efficacy trial of the Sanofipasteur live-attenuated tetravalent dengue vaccine (Dengvaxia), features of hospitalized disease accompanying dengue infections in placebo recipients were closely similar to those in vaccinated children. However, the age specific hospitalization curves for these two populations differed. The curve for children vaccinated at ages 2-16 years closely resembled the 1981 age specific hospitalization rate curve for Cuban children infected with DENV 2 who were sensitized by a prior DENV 1 infection...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29024641/diverse-viruses-require-the-calcium-transporter-spca1-for-maturation-and-spread
#3
H-Heinrich Hoffmann, William M Schneider, Vincent A Blomen, Margaret A Scull, Alain Hovnanian, Thijn R Brummelkamp, Charles M Rice
Respiratory and arthropod-borne viral infections are a global threat due to the lack of effective antivirals and vaccines. A potential strategy is to target host proteins required for viruses but non-essential for the host. To identify such proteins, we performed a genome-wide knockout screen in human haploid cells and identified the calcium pump SPCA1. SPCA1 is required by viruses from the Paramyxoviridae, Flaviviridae, and Togaviridae families, including measles, dengue, West Nile, Zika, and chikungunya viruses...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29020332/dependency-of-vaccine-efficacy-on-pre-exposure-and-age-a-closer-look-at-a-tetravalent-dengue-vaccine
#4
Yang Yang, Ya Meng, M Elizabeth Halloran, Ira M Longini
Background: A recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) was licensed for children of 9 years old or older in a few countries, but the dependence of vaccine efficacy on baseline immunity status and age groups has not been fully characterized. Methods: Combining the two phase III trials, CYD14 and CYD15, we estimated the vaccine efficacy for each of the four serotypes of dengue virus (DENV), as well as all serotypes combined, simultaneously stratified by baseline immunity status and age group, while accounting for uncertainty in the baseline immunity status of subjects...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020226/innate-t-and-b-cell-responses-in-acute-human-zika-patients
#5
Lilin Lai, Nadine Rouphael, Yongxian Xu, Muktha S Natrajan, Allison Beck, Mari Hart, Matthew Feldhammer, Amanda Feldpausch, Charles Hill, Henry Wu, Jessica K Fairley, Pamela Lankford-Turner, Nicole Kasher, Patrick Rago, Yi-Juan Hu, Srilatha Edupuganti, Shital M Patel, Kristy O Murray, Mark J Mulligan
Background: There is an urgent need for studies of viral persistence and immunity during human Zika infections to inform planning and conduct of vaccine clinical trials. Methods: In five returned US travelers with acute symptomatic Zika infection, clinical features, viral RNA levels, and immune responses were characterized. Results: Two pregnant, flavivirus-experienced patients had viral RNA persist in plasma for >44 and >26 days. Three days after symptom onset transient increases in pro-inflammatory monocytes began followed at five days by transient decreases in myeloid dendritic cells...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28993774/the-clinical-application-of-micrornas-in-infectious-disease
#6
REVIEW
Ruth E Drury, Daniel O'Connor, Andrew J Pollard
MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by regulating proteins involved in innate and adaptive immune pathways. miRNAs can govern the cellular tropism of some viruses, are implicated in the resistance of some individuals to infections like HIV, and are associated with impaired vaccine response in older people...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28993770/adjuvant-mediated-epitope-specificity-and-enhanced-neutralizing-activity-of-antibodies-targeting-dengue-virus-envelope-protein
#7
Denicar Lina Nascimento Fabris Maeda, Milene Tavares Batista, Lennon Ramos Pereira, Mariana de Jesus Cintra, Jaime Henrique Amorim, Camila Mathias-Santos, Sara Araújo Pereira, Silvia Beatriz Boscardin, Sandriana Dos Ramos Silva, Eliana L Faquim-Mauro, Vanessa Barbosa Silveira, Danielle Bruna Leal Oliveira, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Juliana Falcão Rodrigues
The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is known about the capacity of these adjuvants to modulate the epitope specificity of antibodies directed against antigens. This study characterizes the role of LT and its non-toxic B subunit (LTB) in the modulation of antibody responses to a coadministered antigen, the dengue virus (DENV) envelope glycoprotein domain III (EDIII), which binds to surface receptors and mediates virus entry into host cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28991321/-role-of-dendritic-cells-in-infection-by-dengue-virus-targets-for-replication-and-immune-response
#8
Jahnnyer Martínez, Juan C Hernández, Silvio Urcuqui-Inchima
Dengue fever, caused by dengue virus (DENV) infection, is one of the most important diseases in the world, not only due to the high morbidity/mortality rates it causes, but also because of its great economic and social impact in tropical/subtropical countries. DENV infection has a wide range of clinical manifestations ranging from asymptomatic infection or infection with mild symptoms to severe dengue that can lead to death. At present, no etiological treatment or effective globally distributed vaccine against the four DENV serotypes exists...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28987441/elaboration-of-tetravalent-antibody-responses-against-dengue-viruses-using-a-subunit-vaccine-comprised-of-a-single-consensus-dengue-envelope-sequence
#9
Jin Sun, Min Li, Yinan Wang, Pei Hao, Xia Jin
Dengue viruses (DENVs) are re-emerging pathogens transmitted by mosquitoes mainly in tropical and subtropical regions. Each year, they are estimated to infect 390 million people globally. The major challenge confronting dengue vaccine development is the need to induce balanced, long lasting tetravalent immune responses against four co-circulating virus serotypes (DENV-I, -II, -III, -IV), because primary infection by any one of which may predispose infected individuals to more severe diseases during a heterotypic secondary infection...
October 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28986841/murine-models-for-viral-hemorrhagic-fever
#10
Rosana Gonzalez-Quintial, Roberto Baccala
Hemorrhagic fever (HF) viruses, such as Lassa, Ebola, and dengue viruses, represent major human health risks due to their highly contagious nature, the severity of the clinical manifestations induced, the lack of vaccines, and the very limited therapeutic options currently available. Appropriate animal models are obviously critical to study disease pathogenesis and develop efficient therapies. We recently reported that the clone 13 (Cl13) variant of the lymphocytic choriomeningitis virus (LCMV-Cl13), a prototype arenavirus closely related to Lassa virus, causes in some mouse strains endothelial damage, vascular leakage, platelet loss, and death, mimicking pathological aspects typically observed in Lassa and other HF syndromes...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986822/global-spread-of-hemorrhagic-fever-viruses-predicting-pandemics
#11
Jean-Paul Gonzalez, Marc Souris, Willy Valdivia-Granda
As successive epidemics have swept the world, the scientific community has quickly learned from them about the emergence and transmission of communicable diseases. Epidemics usually occur when health systems are unprepared. During an unexpected epidemic, health authorities engage in damage control, fear drives action, and the desire to understand the threat is greatest. As humanity recovers, policy-makers seek scientific expertise to improve their "preparedness" to face future events.Global spread of disease is exemplified by the spread of yellow fever from Africa to the Americas, by the spread of dengue fever through transcontinental migration of mosquitos, by the relentless influenza virus pandemics, and, most recently, by the unexpected emergence of Ebola virus, spread by motorbike and long haul carriers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28978707/prior-dengue-virus-exposure-shapes-t-cell-immunity-to-zika-virus-in-humans
#12
Alba Grifoni, John Pham, John Sidney, Patrick H O'Rourke, Sinu Paul, Bjoern Peters, Sheridan R Martini, Aruna D de Silva, Michael J Ricciardi, Diogo M Magnani, Cassia G T Silveira, Alvino Maestri, Priscilla R Costa, Luzia Maria de-Oliveira-Pinto, Elzinandes Leal de Azeredo, Paulo Vieira Damasco, Elizabeth Phillips, Simon Mallal, Aravinda M de Silva, Matthew Collins, Anna Durbin, Sean A Diehl, Cristhiam Cerpas, Angel Balmaseda, Guillermina Kuan, Josefina Coloma, Eva Harris, James E Crowe, Mars Stone, Phillip J Norris, Michael Busch, Hector Vivanco-Cid, Josephine Cox, Barney S Graham, Julie E Ledgerwood, Lance Turtle, Tom Solomon, Esper G Kallas, David I Watkins, Daniela Weiskopf, Alessandro Sette
While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known regarding the corresponding T cell responses to ZIKV. Here we investigate the kinetics and viral epitopes targeted by T cells responding to ZIKV and address the critical question of whether pre-existing dengue virus (DENV) T cell immunity modulates these responses. We find that memory T cell responses elicited by prior infection with DENV or vaccination with Tetravalent Dengue Attenuated Vaccines (TDLAV) recognize ZIKV-derived peptides...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#13
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28969658/characterization-and-epitope-mapping-of-dengue-virus-type-1-specific-monoclonal-antibodies
#14
Wen-Hung Chen, Feng-Pai Chou, Yu-Kuo Wang, Sheng-Cih Huang, Chuan-Hung Cheng, Tung-Kung Wu
BACKGROUND: Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. Four distinct serotypes (DV1-4), which have similar genome sequences and envelope protein (E protein) antigenic properties, were divided. Among these 4 serotypes, DV1 usually causes predominant infections and fast diagnosis and effective treatments are urgently required to prevent further hospitalization and casualties. METHODS: To develop antibodies specifically targeting and neutralizing DV1, we immunized mice with UV-inactivated DV1 viral particles and recombinant DV1 E protein from residue 1 to 395 (E395), and then generated 12 anti-E monoclonal antibodies (mAbs) as the candidates for a series of characterized assays such as ELISA, dot blot, immunofluorescence assay, western blot, and foci forming analyses...
October 2, 2017: Virology Journal
https://www.readbyqxmd.com/read/28968905/yellow-fever-virus-but-not-zika-or-dengue-virus-inhibits-t-cell-receptor-mediated-t-cell-function-by-an-rna-based-mechanism
#15
James H McLinden, Nirjal Bhattarai, Jack T Stapleton, Qing Chang, Thomas M Kaufman, Suzanne L Cassel, Fayyaz S Sutterwala, Hillel Haim, Jon Houtman, Jinhua Xiang
The Flavivirus genus within the Flaviviridae is comprised of many important human pathogens including Yellow Fever virus (YFV), Dengue virus (DENV) and Zika virus (ZKV), all of which are global public health concerns. Although the related flaviviruses hepatitis C virus and human pegivirus (formerly named GBV-C) interfere with T cell receptor (TCR) signaling by novel RNA and protein based mechanisms, the effect of other flaviviruses on TCR signaling is unknown. Here, we studied the effect of YFV, DENV, and ZKV on TCR signaling...
September 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968838/cd-loop-extension-in-zika-virus-envelope-protein-key-for-stability-and-pathogenesis
#16
Emily N Gallichotte, Kenneth H Dinnon, Xin-Ni Lim, Thiam-Seng Ng, Elisa X Y Lim, Vineet D Menachery, Shee-Mei Lok, Ralph S Baric
With severe disease manifestations including microcephaly, congenital malformation, and Guillain-Barré syndrome, Zika virus (ZIKV) remains a persistent global public health threat. Despite antigenic similarities with dengue viruses, structural studies have suggested the extended CD-loop and hydrogen-bonding interaction network within the ZIKV envelope protein contribute to stability differences between the viral families. This enhanced stability may lead to the augmented infection, disease manifestation, and persistence in body fluids seen following ZIKV infection...
September 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968794/replication-and-excretion-of-the-live-attenuated-tetravalent-dengue-vaccine-cyd-tdv-in-a-flavivirus-naive-adult-population-assessment-of-vaccine-viremia-and-virus-shedding
#17
Joseph Torresi, Peter C Richmond, Leon G Heron, Ming Qiao, Joanne Marjason, Linda Starr-Spires, Diane van der Vliet, Jing Jin, T Anh Wartel, Alain Bouckenooghe
Background: We assessed replication and excretion of the live attenuated tetravalent dengue vaccine (CYD-TDV) into biological fluids following vaccination in dengue-naive adults in Australia. Methods: Vaccinal viremia/shedding was assessed in a subset of participants enrolled in a lot-to-lot consistency study; 95 participants received 3 subcutaneous doses of CYD-TDV from phase 2/3 lots of the vaccine, and 8 received placebo; doses were administered 6 months apart...
September 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28966494/nine-year-trends-of-dengue-virus-infection-in-mumbai-western-india
#18
Jayanthi Shastri, Manita Williamson, Nilima Vaidya, Sachee Agrawal, Om Shrivastav
INTRODUCTION: Dengue virus (DENV) causes a wide range of diseases in humans, from acute febrile illness Dengue fever (DF) to life-threatening Dengue hemorrhagic fever (DHF) or Dengue shock syndrome (DSS). Factors believed to be responsible for spread of Dengue virus infection include explosive population growth, unplanned urban overpopulation with inadequate public health systems, poor standing water and vector control, climate changes and increased international recreational, business, military travel to endemic areas...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28959858/-progress-in-zika-virus-and-its-vaccines
#19
Deqiao Tian, Wei Chen
Like Yellow fever virus, Dengue virus, Japanese encephalitis virus and West Nile virus, Zika virus is also a mosquito-borne flavivirus. Since it was isolated in 1947, there has been little concern over Zika virus due to its limited distribution and mild symptoms. In recent years, especially since 2015, Zika virus has become a global concern because of its outbreak in Brazil and associated microcephaly. Vaccines against Zika virus, regarded as the effective measures to control Zika fever epidemic, are being developed in nearly thirty institutions worldwide...
January 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28959246/recent-perspectives-on-genome-transmission-clinical-manifestation-diagnosis-therapeutic-strategies-vaccine-developments-and-challenges-of-zika-virus-research
#20
REVIEW
Apoorva Shankar, Amulya A Patil, Sinosh Skariyachan
One of the potential threats to public health microbiology in 21st century is the increased mortality rate caused by Zika virus (ZIKV), a mosquito-borne flavivirus. The severity of ZIKV infection urged World Health Organization (WHO) to declare this virus as a global concern. The limited knowledge on the structure, virulent factors, and replication mechanism of the virus posed as hindrance for vaccine development. Several vector and non-vector-borne mode of transmission are observed for spreading the disease...
2017: Frontiers in Microbiology
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