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Joanna Przybyl, Lukasz Kidzinski, Trevor Hastie, Maria Debiec-Rychter, Roel Nusse, Matt van de Rijn
OBJECTIVE: Low-grade endometrial stromal sarcomas (LGESS) harbor chromosomal translocations that affect proteins associated with chromatin remodeling Polycomb Repressive Complex 2 (PRC2), including SUZ12, PHF1 and EPC1. Roughly half of LGESS also demonstrate nuclear accumulation of β-catenin, which is a hallmark of Wnt signaling activation. However, the targets affected by the fusion proteins and the role of Wnt signaling in the pathogenesis of these tumors remain largely unknown. METHODS: Here we report the results of a meta-analysis of three independent gene expression profiling studies on LGESS and immunohistochemical evaluation of nuclear expression of β-catenin and Lef1 in 112 uterine sarcoma specimens obtained from 20 LGESS and 89 LMS patients...
March 12, 2018: Gynecologic Oncology
Annika Selvick, Rita Lloyd
The Nuss procedure has become the predominant reason for the use of metal implants by pediatric general and thoracic surgeons. Current guidelines recommend preimplant testing for all patients undergoing the Nuss procedure, which differs from the guidelines for all other orthopedic procedures. This review was done to further evaluate this discrepancy.
February 28, 2018: Dermatitis
Tyler J Titcomb, Samantha T Schmaelzle, Emily T Nuss, Jesse F Gregory, Sherry A Tanumihardjo
BACKGROUND: Hidden hunger affects individuals who chronically consume an inadequate intake of at least 1 micronutrient and is associated with low dietary diversity. Little data are available on dietary intake or status assessment of B vitamins among preschool children in Zambia. OBJECTIVES: The aim of this study was to assess 24-hour dietary recall records obtained from Zambian children aged 3 to 7 years for B vitamin intake in relation to adequacy and change over time in the same community...
January 1, 2018: Food and Nutrition Bulletin
Piotr Cierpikowski, Adam Rzechonek, Piotr Błasiak, Hanna Lisowska, Grzegorz Pniewski, Patric Le Pivert
Pectus excavatum is the most common congenital deformity of the chest. The Nuss procedure is minimally invasive surgical correction of this defect, using retrosternal metal bars. The purpose of the present study was to describe a 15-year experience with the Nuss surgery, and to evaluate the long-term clinical results of the procedure. We retrospectively evaluated 239 patients, aged 14-34, who underwent the Nuss surgery in the years 2002-2016. Postoperative complications were observed in 40/236 (16.9%) patients...
March 11, 2018: Advances in Experimental Medicine and Biology
Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf, Kay Grobe
Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that form insoluble clusters at the surface of producing cells. While several proposed Hh transport modes tie directly into these unusual properties, the crucial step of Hh relay from producing cells to receptors on remote responding cells remains unresolved. Using wing development in Drosophila melanogaster as a model, we show that Hh relay and direct patterning of the 3-4 intervein region strictly depend on proteolytic removal of lipidated N-terminal membrane anchors...
March 9, 2018: ELife
Ueli Braun, Sonja Warislohner, Paul Torgerson, Karl Nuss, Christian Gerspach
BACKGROUND: The study evaluated the results of clinical examination and haematological and serum biochemical analyses in 503 cattle with traumatic reticuloperitonitis (TRP). RESULTS: The most common clinical findings were abnormal demeanour and general condition (87%), decreased rumen motility (72%), poorly digested faeces (57%), decreased rumen fill (49%), fever (43%) and tachycardia (26%). In 58% of the cattle, at least one of three tests for reticular foreign bodies (pinching of the withers, pressure on the xiphoid and percussion of the abdominal wall) was positive, and in 42% all three tests were negative...
March 5, 2018: BMC Veterinary Research
J Patel, S Lal, K Nuss, S P Wilshaw, B von Rechenberg, R M Hall, J L Tipper
Less than optimal particle isolation techniques have impeded analysis of orthopaedic wear debris in vivo. The purpose of this research was to develop and test an improved method for particle isolation from tissue. A volume of 0.018 mm3 of clinically relevant CoCrMo, Ti-6Al-4V or Si3 N4 particles was injected into rat stifle joints for seven days of in vivo exposure. Following sacrifice, particles were located within tissues using histology. The particles were recovered by enzymatic digestion of periarticular tissue with papain and proteinase K, followed by ultracentrifugation using a sodium polytungstate density gradient...
March 2, 2018: Acta Biomaterialia
Colin J Clark, Holger J Pletsch, Jason Wu, Lucas Guillemot, Matthew Kerr, Tyrel J Johnson, Fernando Camilo, David Salvetti, Bruce Allen, David Anderson, Carsten Aulbert, Christian Beer, Oliver Bock, Andres Cuéllar, Heinz-Bernd Eggenstein, Henning Fehrmann, Michael Kramer, Shawn A Kwang, Bernd Machenschalk, Lars Nieder, Markus Ackermann, Marco Ajello, Luca Baldini, Jean Ballet, Guido Barbiellini, Denis Bastieri, Ronaldo Bellazzini, Elisabetta Bissaldi, Roger D Blandford, Elliott D Bloom, Raffaella Bonino, Eugenio Bottacini, Terri J Brandt, Johan Bregeon, Philippe Bruel, Rolf Buehler, Toby H Burnett, Sara Buson, Rob A Cameron, Regina Caputo, Patrizia A Caraveo, Elisabetta Cavazzuti, Claudia Cecchi, Eric Charles, Alexandre Chekhtman, Stefano Ciprini, Lynn R Cominsky, Denise Costantin, Sara Cutini, Filippo D'Ammando, Andrea De Luca, Rachele Desiante, Leonardo Di Venere, Mattia Di Mauro, Niccolò Di Lalla, Seth W Digel, Cecilia Favuzzi, Elizabeth C Ferrara, Anna Franckowiak, Yasushi Fukazawa, Stefan Funk, Piergiorgio Fusco, Fabio Gargano, Dario Gasparrini, Nico Giglietto, Francesco Giordano, Marcello Giroletti, Germán A Gomez-Vargas, David Green, Isabelle A Grenier, Sylvain Guiriec, Alice K Harding, John W Hewitt, Deirdre Horan, Guðlaugur Jóhannesson, Shiki Kensei, Michael Kuss, Giovanni La Mura, Stefan Larsson, Luca Latronico, Jian Li, Francesco Longo, Francesco Loparco, Michael N Lovellette, Pasquale Lubrano, Jeffrey D Magill, Simone Maldera, Alberto Manfreda, Mario N Mazziotta, Julie E McEnery, Peter F Michelson, Nestor Mirabal, Warit Mitthumsiri, Tsunefumi Mizuno, Maria Elena Monzani, Aldo Morselli, Igor V Moskalenko, Eric Nuss, Takashi Ohsugi, Nicola Omodei, Monica Orienti, Elena Orlando, Michele Palatiello, Vaidehi S Paliya, Francesco de Palma, David Paneque, Jeremy S Perkins, Massimo Persic, Melissa Pesce-Rollins, Troy A Porter, Giacomo Principe, Silvia Rainò, Riccardo Rando, Paul S Ray, Massimiliano Razzano, Anita Reimer, Olaf Reimer, Roger W Romani, Pablo M Saz Parkinson, Carmelo Sgrò, Eric J Siskind, David A Smith, Francesca Spada, Gloria Spandre, Paolo Spinelli, Jana B Thayer, David J Thompson, Diego F Torres, Eleonora Troja, Giacomo Vianello, Kent Wood, Matthew Wood
Millisecond pulsars (MSPs) are old neutron stars that spin hundreds of times per second and appear to pulsate as their emission beams cross our line of sight. To date, radio pulsations have been detected from all rotation-powered MSPs. In an attempt to discover radio-quiet gamma-ray MSPs, we used the aggregated power from the computers of tens of thousands of volunteers participating in the Einstein@Home distributed computing project to search for pulsations from unidentified gamma-ray sources in Fermi Large Area Telescope data...
February 2018: Science Advances
Annika Selvick, Rita Lloyd
The Nuss procedure has become the predominant reason for the use of metal implants by pediatric general and thoracic surgeons. Current guidelines recommend preimplant testing for all patients undergoing the Nuss procedure, which differs from the guidelines for all other orthopedic procedures. This review was done to further evaluate this discrepancy.
February 28, 2018: Dermatitis
Mariela Dore, Paloma Triana Junco, Carlos De La Torre, Alejandra Vilanova-Sánchez, Monserrat Bret, Gaspar Gonzalez, Vanesa Nuñez Cerezo, Javier Jimenez Gomez, Jose Luis Encinas, Francisco Hernandez, Leopoldo Martínez Martínez, Manuel Lopez Santamaria
Introduction  Minimally invasive repair for pectus excavatum (MIRPE) is controversial in extremely severe cases of pectus excavatum (PE) and an open repair is usually favored. Our aim is to describe a case of a patient with an extremely severe PE that underwent a minimally invasive approach. Case report  An 8-year-old girl with severe sternum depression was assessed. She had a history of exercise intolerance, nocturnal dyspnea, fatigue, and shortness of breath. Chest computed tomography showed that sternum depression was posterior to the anterior vertebral column; therefore, Haller and correction index could not be measured...
January 2018: European Journal of Pediatric Surgery Reports
Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nüssing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi H O Nguyen, Katherine Kedzierska
Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infections. IIV activates B cells and T follicular helper (T FH ) cells and thus engenders antibody-secreting cells and serum antibody titers. However, the cellular events preceding generation of protective immunity in humans are inadequately understood. We undertook an in-depth analysis of B cell and T cell immune responses to IIV in 35 healthy adults. Using recombinant hemagglutinin (rHA) probes to dissect the quantity, phenotype, and isotype of influenza-specific B cells against A/California09-H1N1, A/Switzerland-H3N2, and B/Phuket, we showed that vaccination induced a three-pronged B cell response comprising a transient CXCR5 - CXCR3 + antibody-secreting B cell population, CD21 hi CD27 + memory B cells, and CD21 lo CD27 + B cells...
February 14, 2018: Science Translational Medicine
Meg Skizim, Melinda Sothern, Ondrej Blaha, Tung Sung Tseng, Lauren Griffiths, Jonathan Joseph, Henry Nuss
The aim of the present paper is to assess local residents' awareness of utilizing Supplemental Nutrition Assistance Program (SNAP) benefits to purchase fresh produce at local farmers' markets, and to determine internet use and media preferences of study participants prior to implementation of a social marketing campaign. A needs assessment was conducted to collect baseline data in an underserved neighbourhood in New Orleans (La, USA). The study was carried out August 2014-May 2015. The assessment revealed that 73% of the respondents were unaware that the SNAP benefits could be used to purchase food in farmers' markets; 63% of low-income participants never attended a farmers' market compared to 27% of mid/high-income...
December 13, 2017: Journal of Public Health Research
MennatAllah M Ewais, Shivani Chaparala, Rebecca Uhl, Dawn E Jaroszewski
Pectus excavatum (PEx) is one of the most common congenital chest wall deformities. Depending on the severity, presentation of PEx may range from minor cosmetic issues to disabling cardiopulmonary symptoms. The effect of PEx on adult patients has not been extensively studied. Symptoms may not occur until the patient ages, and they may worsen over the years. More recent publications have implied that PEx may have significant cardiopulmonary implications and repair is of medical benefit. Adults presenting for PEx repair can undergo a successful repair with a minimally invasive "Nuss" approach...
2018: Patient related Outcome Measures
Michael G Milgroom, Myron L Smith, Milton T Drott, Donald L Nuss
Balancing selection has been inferred in diverse organisms for nonself recognition genes, including those involved in immunity, mating compatibility, and vegetative incompatibility. Although selective forces maintaining polymorphisms are known for genes involved in immunity and mating, mechanisms of balancing selection for vegetative incompatibility genes in fungi are being debated. We hypothesized that allorecognition and its consequent inhibition of virus transmission contribute to the maintenance of polymorphisms in vegetative incompatibility loci (vic) in the chestnut blight fungus, Cryphonectria parasitica...
February 10, 2018: Heredity
W P Zuidema, J W A Oosterhuis, G W Zijp, S M van der Heide, A F W van der Steeg, L W E van Heurn
BACKGROUND: An early observation after chest wall correction is direct inspection from the PE patient of their "new" thorax. Changes in self-perception may give raise to other psychological adaptations. The aim of this study was to evaluate the early changes in the fields of self-esteem, body image and QoL. METHODS: Prospective observational longitudinal multicenter cohort study. Self-esteem, emotional limitations and general health were assessed using the Child Health Questionnaire (CHQ) in patients under 18 and the World Health Organization Quality of Life Questionnaire-bref (WHOQOL-bref) was used for body image, psychological domain and overall QoL in patients over 16 years of age...
February 6, 2018: World Journal of Surgery
Xicheng Deng, Peng Huang, Liwen Yi, Xiaohui Yang, Cheng He
RATIONALE: Pectus excavatum (PE) in the setting of congenital heart disease is not uncommon. The surgical strategy has evolved over the last 20 years from a staged approach to simultaneous repair of both defects. PATIENT CONCERNS: A 3-year-old boy was admitted for elective repair of PE and atrial septal defect (ASD). DIAGNOSES: Clinically, there were obvious features of PE and a grade 2 systolic murmur heard loudest at the 2nd intercostal space abutting the left sternal border...
December 2017: Medicine (Baltimore)
Wiebke Heine, Michael Beckstette, Ann Kathrin Heroven, Sophie Thiemann, Ulrike Heise, Aaron Mischa Nuss, Fabio Pisano, Till Strowig, Petra Dersch
Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying gut-associated lymphatic tissues. How the bacteria gain a foothold in the face of host immune responses is poorly understood. Here, we show that the CNFY toxin, which enhances translocation of the antiphagocytic Yop effectors, induces inflammatory responses...
February 2018: PLoS Pathogens
M Hässig, C Degen Aguayo Aparicio, K Nuss
The aim of the study was to clarify how lameness and its severity in dairy cows at the time of drying off will affect the milk performance and fertility in the following lactation when treated appropriately at the time of drying off. The lameness scoring and a gait assessment took place during drying off, in the 1st week after calving, as well as 2 months after calving. Each lame cow was compared with a non-lame control cow from the same farm. The milk and fertility data of the following lactation were compared with those of the previous lactation...
February 2018: Schweizer Archiv Für Tierheilkunde
M Hässig, C Degen Aguayo Aparicio, K Nuss
The aim of this study was to investigate the relationship between lameness scoring and clinical findings. The lameness scoring and a gait assessment took place during drying off, the first week after calving and two months after calving in 29 lame and 27 free of lameness cows. In between the farmer scored the lamness. Most of the lameness occurred in the hind limbs and were most frequently caused by dermatitis digitalis, Mortellaro, Limax, and Rusterholz sole ulcer. The mean duration of lameness after treatment was 26 days (median 16 days) and was significantly longer in case of horn lesions than in skin lesions (including interdigital dermatitis)...
February 2018: Schweizer Archiv Für Tierheilkunde
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H O Nguyen, Katherine Kedzierska
Influenza is a major global health problem, causing infections of the respiratory tract, often leading to acute pneumonia, life-threatening complications and even deaths. Over the last seven decades, vaccination strategies have been utilized to protect people from complications of influenza, especially groups at high risk of severe disease. While current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avian viruses. Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized...
January 20, 2018: Frontiers of Medicine
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