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https://www.readbyqxmd.com/read/28813421/stromal-r-spondin-orchestrates-gastric-epithelial-stem-cells-and-gland-homeostasis
#1
Michael Sigal, Catriona Y Logan, Marta Kapalczynska, Hans-Joachim Mollenkopf, Hilmar Berger, Bertram Wiedenmann, Roeland Nusse, Manuel R Amieva, Thomas F Meyer
The constant regeneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates their turnover is not well understood. We have recently found that the gastric pathogen Helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while Wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues. Here we find that antral Wnt signalling, marked by the classic Wnt target gene Axin2, is limited to the base and lower isthmus of gastric glands, where the stem cells reside...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28757834/anesthesia-for-minimally-invasive-chest-wall-reconstructive-surgeries-our-experience-and-review-of-literature
#2
REVIEW
Shagun Bhatia Shah, Uma Hariharan, Ajay Kumar Bhargava, Laleng M Darlong
Minimal access procedures have revolutionized the field of surgery and opened newer challenges for the anesthesiologists. Pectus carinatum or pigeon chest is an uncommon chest wall deformity characterized by a protruding breast bone (sternum) and ribs caused by an overgrowth of the costal cartilages. It can cause a multitude of problems, including severe pain from an intercostal neuropathy, respiratory dysfunction, and psychologic issues from the cosmetic disfigurement. Pulmonary function indices, namely, forced expiratory volume over 1 s, forced vital capacity, vital capacity, and total lung capacity are markedly compromised in pectus excavatum...
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28747942/complex-corrective-procedure-in-surgical-treatment-of-asymmetrical-pectus-excavatum
#3
Krystian Pawlak, Łuksasz Gąsiorowski, Wojciech Dyszkiewicz
AIM: In this study we analysed the early and late results of surgical treatment of asymmetrical pectus excavatum using complex surgery combining the Ravitch procedure and the Nuss procedure in the same general anaesthesia. MATERIAL AND METHODS: Eighty out of 938 patients with pectus excavatum operated on between 2002 and 2013, 67 males and 13 females aged 11 to 49 years (mean: 19.2), underwent a complex surgical procedure. During surgery the Nuss procedure was usually performed first (one corrective bar was implanted in 35 patients and two bars were inserted in 45 patients)...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28745702/-differential-approach-for-chest-wall-reconstruction-for-pectus-excavatum-in-adults
#4
A A Pechetov, Yu S Esakov, G F Gubaydullina, M A Makov, T N Khlan
AIM: To perform the prospective non-randomized single-center trial of pectus excavatum correction in adults. MATERIAL AND METHODS: For the period March 2012 - March 2016 64 patients aged 18-44 years were treated. Median age was 23 years. Male/female ratio was 41/23. All patients were included into standard survey protocol: chest MDCT, MRI of thoracic spine, pulmonary function test, echocardiography. Quality of life and complications rate after the Nuss procedure (n=50, 78...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28738822/cardiac-arrest-without-physical-cardiac-injury-during-nuss-repair-of-pectus-excavatum
#5
Jianyong Zou, Canqiao Luo, Zhenguo Liu, Chao Cheng
BACKGROUND: Cardiac arrest is a lethal complication of Nuss repair of pectus excavatum which is strongly related to heart or big vessels injury. A rare case developed cardiac arrest without direct cardiac injury during Nuss procedure is presented in this article. CASE PRESENTATION: In July 2015, a previously healthy 18-year-old man undergoing Nuss repair for pectus excavatum developed cardiac arrest while the Nuss bar was being inserted into the chest. After successful resuscitation and exclusion of direct cardiac injury, the Nuss procedure was continued...
July 24, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28737935/the-current-state-of-peptide-drug-discovery-back-to-the-future
#6
Antoine Henninot, James C Collins, John M Nuss
Over the last decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs, and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological therapeutics. In this perspective we give a concise description of the recent progress in peptide drug discovery in a holistic manner, highlighting enabling technological advances affecting nearly every aspect of this field: from lead discovery, to synthesis and optimization, to peptide drug delivery...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28714634/-pectus-excavatumn-and-carinatum-in-children-and-adolescents-what-to-say-what-to-do
#7
Pierre Lascombes, Isabelle Ruchonnet-Métrailler, Maurice Beghetti, Armand Bottani, James Wilde
In children presenting with a pectus excavatum (PE) or pectus carinatum (PC) an underlying syndrome including Marfan's syndrome needs to be excluded. In adolescents, severe chest wall deformities may cause cardiac or respiratory problems but most commonly they have a psychological impact. The conservative treatment is a Vacuum Bell for PE, and a Dynamic Compression System for PC ; they play an increasing role in young patients. These devices need to be worn multiple hours per day for several months for an optimal result...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28662867/thoracic-outlet-syndrome-after-the-nuss-procedure-for-pectus-excavatum-is-it-a-rare-complication
#8
Tomohisa Nagasao, Tadaaki Morotomi, Motone Kuriyama, Tetsukuni Kogure, Hirro Kudo, Yusuke Hamamoto, Motoki Tamai
OBJECTIVE: The present study aims to elucidate the frequency of thoracic outlet syndrome after the Nuss procedure for pectus excavatum and the conditions in which thoracic outlet syndrome is likely to develop. METHODS: A retrospective study including 85 pectus excavatum patients (58 males and 27 females) was conducted. Thoracic outlet syndrome was defined as a condition in which the patient has numbness, lassitude, or pain of the upper limbs at rest or during motion of the upper limbs...
June 3, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28648192/-contemporary-behavioural-addictions-an-overview-and-the-nursing-position
#9
Philippe Nuss
Behavioural addiction is characterised by thoughts focused on a particular activity and its repetition, with a significant amount of time devoted to this activity at the expense of others. The nurse must adapt to these addicts by treating them as individuals without judging them and by trying to understand how they have tried, through this behaviour, to resolve their issues. The challenge is to reposition the body at the heart of the nursing relationship.
June 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28626162/intervention-of-the-nuss-procedure-on-the-mental-health-of-pectus-excavatum-patients
#10
Li Luo, Bo Xu, Xinling Wang, Bo Tan, Jing Zhao
Pectus excavatum (PE) is the most common congenital chest wall deformity, but little is known about the influence of the Nuss surgical procedure on mental health of patients with PE. In this study, we aimed to evaluate the influence of the PE Nuss surgical procedure on mental health in Chinese patients and identify the predictors of psychological status for PE. Patients with PE (n = 266) underwent a standard surgical procedure by the same surgeon and did the Symptom Checklist 90 (SCL-90) and the Self-rating Depression Scale (SDS) questionnaires before and 1 year after surgery...
June 16, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28616300/late-cardiac-tamponade-following-nuss-procedure-for-pectus-excavatum
#11
Jong-Hyun Baek, Young-Uk Lee, Tae-Eun Jung, Dong-Hyup Lee, Jung-Cheul Lee
The Nuss procedure is a recently developed technique for correction of pectus excavatum. A 23-year-old female patient presented at our emergency department with clinical signs of cardiac tamponade, which required an emergency procedure. Sixteen months ago, she underwent the Nuss procedure with a single bar. Her preoperative Haller index was 5. We report on a case of delayed recurrent cardiac tamponade that occurred 16 and 18 months after the patient underwent the Nuss procedure; in this case, we treated the patient with pericardiocentesis the first time and performed pericardial window creation with bar removal the second time...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28615652/development-of-a-computer-aided-design-and-finite-element-analysis-combined-method-for-customized-nuss-bar-in-pectus-excavatum-surgery
#12
Longhan Xie, Siqi Cai, Liang Xie, Gang Chen, Haiyu Zhou
Pectus excavatum (PEX) is the most common chest deformity in children, which is usually corrected by using the minimally invasive Nuss method. The orthopedic effect of the Nuss operation is mainly evaluated by both the Haller index and the appearance of the chest wall configuration, which is dependent on the operator's clinical experience to a great extent. To improve the orthopedic effect, we proposed a novel method to individually design and optimize the shape of the Nuss bar and to advise its location as well as the incisions...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609962/-i-macrocyrtus-i-i-imomzodai-i-bar%C3%A5-evskis-2016-a-new-synonym-of-i-metapocyrtus-i-i-orthocyrtus-i-i-orbiferoides-i-schultze-1918-coleoptera-curculionidae-entiminae
#13
Hiraku Yoshitake
Metapocyrtus (Orthocyrtus) orbiferoides Schultze, 1918 was described based on the female holotype collected from Ilocos Norte, North Luzon, Philippines. Since that time, it has been left unstudied for almost a century until I examined the holotype of M. (O.) orbiferoides in 2010 at Senckenberg Naturhistorische Sammlungen, Museum für Tierkunde, Dresden (SMTD). Recently, Barševskis (2016) described Macrocyrtus imomzodai based on two female specimens from Ilocos Norte, Luzon. Judging from the original description and dorsal and lateral habitus images, it is quite apparent that M...
April 18, 2017: Zootaxa
https://www.readbyqxmd.com/read/28606386/comparison-of-the-nuss-versus-ravitch-procedure-for-pectus-excavatum-repair-an-updated-meta-analysis
#14
Yong Zhong Mao, ShaoTao Tang, Shuai Li
BACKGROUND/PURPOSE: To evaluate surgical outcomes of Nuss versus Ravitch repair of pectus excavatum via a systematic review and meta-analysis. METHODS: Medline, PubMed, Cochrane, EMBASE, and Google Scholar databases were searched up to September 5, 2016 using the following search terms: pectus excavatum, funnel chest, Nuss; Ravitch, minimally invasive, and open surgery. Randomized controlled trials, two-arm prospective, and two-arm retrospective studies were eligible for inclusion...
June 3, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28593866/-open-digit-amputation-in-cattle-surgery-wound-healing-and-follow-up
#15
D Devaux, A Steiner, F Pipoz, K Nuss
The aim of this retrospective study was to document secondary wound healing and outcome in 20 cattle that had undergone digit amputation at the level of the distal metaphysis of the first phalanx between April 2009 and June 2015. The surgical technique for amputation was simple and fast, and granulation tissue covered the stump of the first phalanx 9 to 30 days postoperatively. Complications associated with wound healing were seen in 7 animals and in 3, a second surgery was required; all 20 cattle were discharged from the clinic...
June 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28577203/the-non-union-scoring-system-an-interobserver-reliability-study
#16
M van Basten Batenburg, I B Houben, T J Blokhuis
PURPOSE: The Non-Union Scoring System (NUSS) aims to classify non-unions according to their severity and relate them to four treatment categories. The main purpose of this study was to evaluate the reliability of the NUSS. In addition we assessed its clinical validity. METHODS: Forty-four Patients with a tibia non-union between 2005 and 2015 were included in this study. Data from all included patients were scored independently by three observers according to the NUSS criteria...
June 2, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28575679/wnt-%C3%AE-catenin-signaling-disease-and-emerging-therapeutic-modalities
#17
REVIEW
Roel Nusse, Hans Clevers
The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.
June 1, 2017: Cell
https://www.readbyqxmd.com/read/28518080/rearing-ixodes-scapularis-the-black-legged-tick-feeding-immature-stages-on-mice
#18
Andrew B Nuss, Manoj G Mathew, Monika Gulia-Nuss
Ixodes scapularis, the vector of Lyme disease, is one of the most important disease vectors in the eastern and Midwestern United States. This species is a three host tick that requires a blood meal from a vertebrate host for each development stage, and the adult females require a blood meal for reproduction. Larval ticks attach to their host for 3 - 5 days for feeding and drop off the host when fully engorged. This dependency on several different hosts and the lengthy attachment time for engorgement complicates tick rearing in the laboratory setting...
May 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28508918/-local-anaesthesia-in-ruminants
#19
REVIEW
Karl Nuss, Andrea Schwarz, Simone Ringer
The use of local anaesthesia in ruminants allows many surgical procedures to be conducted free of pain, efficiently and inexpensively in the field. Local anaesthesia combined with sedation and immobilisation of the animal can replace general anaesthesia for many procedures (e. g. castration, claw amputation). The level of difficulty differs among various local anaesthetic techniques: local infiltration of tissue or anaesthesia of the cornual nerve are easily performed, whereas local anaesthesia of the eye, regional anaesthesia in limbs or anaesthesia for umbilical surgery are more difficult to carry out...
June 20, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28502740/isolation-of-an-insulin-like-peptide-from-the-asian-malaria-mosquito-anopheles-stephensi-that-acts-as-a-steroidogenic-gonadotropin-across-diverse-mosquito-taxa
#20
Andrew B Nuss, Mark R Brown
Many insulin-like peptides (ILPs) have been identified in insects, yet only a few were isolated in their native form for structural and functional studies. Antiserum produced to ILP3 in Aedes aegypti was used in a radioimmunoassay to monitor the purification of an ILP from heads of adult An. stephensi and recognized the ILP in other immunoassays. The structure of the purified peptide matched that predicted for the ILP3 in this species. The native form stimulated ecdysteroid production by ovaries isolated from non-blood fed females...
May 11, 2017: General and Comparative Endocrinology
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