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https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#1
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28893382/pain-and-sensory-disturbances-following-surgical-repair-of-pectus-carinatum
#2
Marie Veje Knudsen, Hans K Pilegaard, Kasper Grosen
BACKGROUND/PURPOSE: The purpose of this study was to assess the characteristics of persistent postoperative pain and sensory disturbances following surgical repair of pectus carinatum. METHODS: Using a prospective observational design, 28 patients were assessed before, 6 weeks and 6 months after a modified Ravitch operation for pectus carinatum. Postoperative pain was assessed using the Short Form McGill Pain Questionnaire. Sensory testing was conducted to detect brush-evoked allodynia and pinprick hyperalgesia...
August 25, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28886197/in-vivo-lineage-tracing-reveals-axin2-expressing-long-lived-cortical-thymic-epithelial-progenitors-in-the-postnatal-thymus
#3
Si Hui Tan, Roel Nusse
In the thymus, cortical and medullary thymic epithelial cells (TECs) are instrumental for generating a repertoire of functional T cells. Hence, there has been much interest in the ontogeny of TECs. While medullary TEC (mTEC) and bipotent progenitors have been identified, the existence of a cortical TEC (cTEC) progenitor remains ambiguous. In this study, we used lineage tracing based on a target gene of the Wnt pathway, Axin2. We found that Axin2 initially labels cells in both the cortical and medullary compartments...
2017: PloS One
https://www.readbyqxmd.com/read/28879663/road-side-drug-testing-an-evaluation-of-the-alere-dds%C3%A2-2-mobile-test-system
#4
Timothy P Rohrig, Christine M Moore, Kimberly Stephens, Kelsey Cooper, Cynthia Coulter, Tyson Baird, Margaux Garnier, Samuel Miller, James Tuyay, Kei Osawa, Joshua Chou, Carson Nuss, Jeff Collier, Karen Cudlin Wittman
The number of drivers using drugs has increased over the last few years, and is likely to continue its upward trend. Testing drivers for alcohol use is routine and standardized, but the same is not true for the identification of driving under the influence of drugs (DUID). The Drug Evaluation and Classification Program (DECP) was developed to train police officers to recognize the signs and symptoms of recent drug use and remains an invaluable program; however there are insufficient numbers of these highly trained drug recognition experts (DRE's) who are available to attend every potential drug involved traffic incident...
September 6, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28878918/development-of-harlequin-syndrome-following-placement-of-thoracic-epidural-anesthesia-in-a-pediatric-patient-undergoing-nuss-procedure
#5
Ashley Lefevre, Gregory Schnepper
We report the development of Harlequin Syndrome following thoracic epidural placement in a pediatric patient. Unilateral facial flushing with contralateral pallor and anhidrosis is the clinical presentation. This syndrome is typically benign. When related to regional anesthesia, treatment involves reducing the local anesthetic infusion or stopping it altogether.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28859507/association-between-low-barometric-pressure-and-completed-suicides
#6
Rif S El-Mallakh, Kanwar Brar, Claire Watkins, Sharon Nuss, Stephen S O'Connor, Yonglin Gao, Jesse H Wright
No abstract text is available yet for this article.
September 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28855092/extending-the-upper-temperature-range-of-gas-chromatography-with-all-silicon-microchip-columns-using-a-heater-clamp-assembly
#7
Abhijit Ghosh, Jacob E Johnson, Johnathan G Nuss, Brittany A Stark, Aaron R Hawkins, Luke T Tolley, Brian D Iverson, H Dennis Tolley, Milton L Lee
Miniaturization of gas chromatography (GC) instrumentation is of interest because it addresses current and future issues relating to compactness, portability and field application. While incremental advancements continue to be reported in GC with columns fabricated in microchips (referred to in this paper as "microchip columns"), the current performance is far from acceptable. This lower performance compared to conventional GC is due to factors such as pooling of the stationary phase in corners of non-cylindrical channels, adsorption of sensitive compounds on incompletely deactivated surfaces, shorter column lengths and less than optimum interfacing to injector and detector...
August 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28837456/temporal-healing-of-achilles-tendons-after-injury-in-rodents-depends-on-surgical-treatment-and-activity
#8
Benjamin R Freedman, Nabeel S Salka, Tyler R Morris, Pankti R Bhatt, Adam M Pardes, Joshua A Gordon, Courtney A Nuss, Corinne N Riggin, George W Fryhofer, Daniel C Farber, Louis Soslowsky
INTRODUCTION: Achilles tendon ruptures affect 15 of 100,000 women and 55 of 100,000 men each year. Controversy continues to exist regarding optimal treatment and rehabilitation protocols. The objective of this study was to investigate the temporal effects of surgical repair and immobilization or activity on Achilles tendon healing and limb function after complete transection in rodents. METHODS: Injured tendons were repaired (n = 64) or left nonrepaired (n = 64)...
September 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28827049/the-effect-of-thoracoscopy-upon-the-repair-of-pectus-excavatum
#9
Nicole Mennie, Geoff Frawley, Joe Crameri, Sebastian K King
BACKGROUND/AIMS: The Nuss procedure is the most commonly performed operation to correct pectus excavatum (PE). Thoracoscopic assistance has been anecdotally noted to improve the safety of this operative approach. This study aimed to compare complications and clinical outcomes before and after the introduction of thoracoscopy in a single-center. METHODS: A retrospective review was performed of all patients who underwent the Nuss procedure at The Royal Children's Hospital over an 11-year period (2005-2015), collecting data on all intra-operative and post-operative outcomes...
July 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28822540/life-threatening-complications-and-mortality-of-minimally-invasive-pectus-surgery
#10
André Hebra, Robert E Kelly, Marcelo M Ferro, Mustafa Yüksel, Jose Ribas M Campos, Donald Nuss
The prevalence and type of life-threatening complications related to the minimally invasive repair of pectus excavatum (MIRPE) and bar removal are unknown and underreported. The purpose of this communication is to make surgeons aware of the risk of these life threatening complications as well as the modifications which have been developed to prevent them. METHODS: Data related to life-threatening complications of Pectus Excavatum (PE) patients was obtained from four sources: 1. A survey of Chest Wall International Group (CWIG) surgeons who specialize in repairing congenital chest wall malformations, 2...
July 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28820011/unusual-complication-of-the-nuss-procedure-fistulization-of-the-internal-thoracic-artery-to-the-pulmonary-artery
#11
Michael C Mongé, David Wax, Katherine Barsness
Although minimally invasive repair of pectus excavatum has been shown to have a low complication rate in large series, several case reports have documented life-threatening complications, including bleeding and cardiac perforation. We present a rare case of an arteriovenous malformation from the internal thoracic artery to the pulmonary artery caused by occlusion of the internal thoracic artery by the Nuss bar followed by an unidentified angiogenic process. The patient became symptomatic and required transcatheter coil embolization...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28815317/comparison-of-usda-forest-service-and-stakeholder-motivations-and-experiences-in-collaborative-federal-forest-governance-in-the-western-united-states
#12
Emily Jane Davis, Eric M White, Lee K Cerveny, David Seesholtz, Meagan L Nuss, Donald R Ulrich
In the United States, over 191 million acres of land is managed by the United States Department of Agriculture Forest Service, a federal government agency. In several western U.S. states, organized collaborative groups have become a de facto governance approach to providing sustained input on management decisions on much public land. This is most extensive in Oregon, where at least 25 "forest collaboratives" currently exist. This affords excellent opportunities for studies of many common themes in collaborative governance, including trust, shared values, and perceptions of success...
August 16, 2017: Environmental Management
https://www.readbyqxmd.com/read/28813421/stromal-r-spondin-orchestrates-gastric-epithelial-stem-cells-and-gland-homeostasis
#13
Michael Sigal, Catriona Y Logan, Marta Kapalczynska, Hans-Joachim Mollenkopf, Hilmar Berger, Bertram Wiedenmann, Roeland Nusse, Manuel R Amieva, Thomas F Meyer
The constant regeneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates their turnover is not well understood. We have recently found that the gastric pathogen Helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while Wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues. Here we find that antral Wnt signalling, marked by the classic Wnt target gene Axin2, is limited to the base and lower isthmus of gastric glands, where the stem cells reside...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28757834/anesthesia-for-minimally-invasive-chest-wall-reconstructive-surgeries-our-experience-and-review-of-literature
#14
REVIEW
Shagun Bhatia Shah, Uma Hariharan, Ajay Kumar Bhargava, Laleng M Darlong
Minimal access procedures have revolutionized the field of surgery and opened newer challenges for the anesthesiologists. Pectus carinatum or pigeon chest is an uncommon chest wall deformity characterized by a protruding breast bone (sternum) and ribs caused by an overgrowth of the costal cartilages. It can cause a multitude of problems, including severe pain from an intercostal neuropathy, respiratory dysfunction, and psychologic issues from the cosmetic disfigurement. Pulmonary function indices, namely, forced expiratory volume over 1 s, forced vital capacity, vital capacity, and total lung capacity are markedly compromised in pectus excavatum...
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28747942/complex-corrective-procedure-in-surgical-treatment-of-asymmetrical-pectus-excavatum
#15
Krystian Pawlak, Łuksasz Gąsiorowski, Wojciech Dyszkiewicz
AIM: In this study we analysed the early and late results of surgical treatment of asymmetrical pectus excavatum using complex surgery combining the Ravitch procedure and the Nuss procedure in the same general anaesthesia. MATERIAL AND METHODS: Eighty out of 938 patients with pectus excavatum operated on between 2002 and 2013, 67 males and 13 females aged 11 to 49 years (mean: 19.2), underwent a complex surgical procedure. During surgery the Nuss procedure was usually performed first (one corrective bar was implanted in 35 patients and two bars were inserted in 45 patients)...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28745702/-differential-approach-for-chest-wall-reconstruction-for-pectus-excavatum-in-adults
#16
A A Pechetov, Yu S Esakov, G F Gubaydullina, M A Makov, T N Khlan
AIM: To perform the prospective non-randomized single-center trial of pectus excavatum correction in adults. MATERIAL AND METHODS: For the period March 2012 - March 2016 64 patients aged 18-44 years were treated. Median age was 23 years. Male/female ratio was 41/23. All patients were included into standard survey protocol: chest MDCT, MRI of thoracic spine, pulmonary function test, echocardiography. Quality of life and complications rate after the Nuss procedure (n=50, 78...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28738822/cardiac-arrest-without-physical-cardiac-injury-during-nuss-repair-of-pectus-excavatum
#17
Jianyong Zou, Canqiao Luo, Zhenguo Liu, Chao Cheng
BACKGROUND: Cardiac arrest is a lethal complication of Nuss repair of pectus excavatum which is strongly related to heart or big vessels injury. A rare case developed cardiac arrest without direct cardiac injury during Nuss procedure is presented in this article. CASE PRESENTATION: In July 2015, a previously healthy 18-year-old man undergoing Nuss repair for pectus excavatum developed cardiac arrest while the Nuss bar was being inserted into the chest. After successful resuscitation and exclusion of direct cardiac injury, the Nuss procedure was continued...
July 24, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28737935/the-current-state-of-peptide-drug-discovery-back-to-the-future
#18
Antoine Henninot, James C Collins, John M Nuss
Over the last decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs, and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological therapeutics. In this perspective we give a concise description of the recent progress in peptide drug discovery in a holistic manner, highlighting enabling technological advances affecting nearly every aspect of this field: from lead discovery, to synthesis and optimization, to peptide drug delivery...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28714634/-pectus-excavatumn-and-carinatum-in-children-and-adolescents-what-to-say-what-to-do
#19
Pierre Lascombes, Isabelle Ruchonnet-Métrailler, Maurice Beghetti, Armand Bottani, James Wilde
In children presenting with a pectus excavatum (PE) or pectus carinatum (PC) an underlying syndrome including Marfan's syndrome needs to be excluded. In adolescents, severe chest wall deformities may cause cardiac or respiratory problems but most commonly they have a psychological impact. The conservative treatment is a Vacuum Bell for PE, and a Dynamic Compression System for PC ; they play an increasing role in young patients. These devices need to be worn multiple hours per day for several months for an optimal result...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28662867/thoracic-outlet-syndrome-after-the-nuss-procedure-for-pectus-excavatum-is-it-a-rare-complication
#20
Tomohisa Nagasao, Tadaaki Morotomi, Motone Kuriyama, Tetsukuni Kogure, Hirro Kudo, Yusuke Hamamoto, Motoki Tamai
OBJECTIVE: The present study aims to elucidate the frequency of thoracic outlet syndrome after the Nuss procedure for pectus excavatum and the conditions in which thoracic outlet syndrome is likely to develop. METHODS: A retrospective study including 85 pectus excavatum patients (58 males and 27 females) was conducted. Thoracic outlet syndrome was defined as a condition in which the patient has numbness, lassitude, or pain of the upper limbs at rest or during motion of the upper limbs...
October 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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