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https://www.readbyqxmd.com/read/29078605/uniportal-nuss-procedure-for-pectus-excavatum-where-to-place-the-camera-but-we-ve-always-done-it-this-way
#1
Ivan Schewitz
This study was stimulated by the increasing use of uniportal thoracoscopic surgery. If a lobectomy can be performed through one small incision why not the much simpler Nuss procedure? The Nuss procedure was performed with the use of the surgical incision for the camera. Initially the patient was positioned so that the standard site for the camera could be utilized. Once it become obvious that the uniportal approach worked the patient was positioned in the middle of the table. In all cases the uniportal approach in my hands was easy and made the operation less cumbersome...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29061495/femoral-osteochondroplasty-can-be-performed-effectively-without-the-risk-of-avascular-necrosis-or-femoral-neck-fractures-in-an-experimental-ovine-fai-model
#2
F Schmaranzer, L Arendt, T D Lerch, S D Steppacher, K Nuss, N Wolfer, H E Dawson, B von Rechenberg, P R Kircher, M Tannast
OBJECTIVE: The experimental induction of cam-type femoroacetabular impingement (FAI) in sheep is established. To tap the full potential of this ovine model, one should be able to perform a femoral osteochondroplasty safely. This study was based on previous cadaver experiments on the blood supply to the ovine femoral head and on the biomechanical strength of the proximal femur following offset creation. We hypothesized that offset creation in this ovine FAI model does not lead to (1) avascular necrosis (AVN) of the ovine femoral head or (2) iatrogenic femoral neck fractures and (3) can be performed effectively...
October 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29052000/results-of-pectus-excavatum-correction-using-a-minimally-invasive-approach-with-subxyphoid-incision-and-three-point-fixation
#3
Sheldon J Bond, Emily Rapstine, Jordan M Bond
OBJECTIVES: This study reviews the results of our previously described modification of the minimally invasive (Nuss) procedure for correction of pectus excavatum. It utilizes a subxyphoid incision with central fixation to maximize safe bar passage and minimize bar displacement. METHODS: Consecutive patients corrected with the modified Nuss procedure between 2010 and 2015 form the basis of this study. RESULTS: During the study period, 73 patients had correction of their pectus excavatum by the modified Nuss procedure, utilizing subxyphoid incision and central fixation...
October 19, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29033723/postoperative-pain-management-in-patients-undergoing-thoracoscopic-repair-of-pectus-excavatum-a-retrospective-analysis-of-opioid-consumption-and-adverse-effects-in-adolescents
#4
Ralph Beltran, Giorgio Veneziano, Tarun Bhalla, Brian Kenney, Dmitry Tumin, Bruno Bissonnette, Joseph D Tobias
INTRODUCTION: Although the Nuss procedure provides excellent cosmetic results for the correction of pectus excavatum, the provision of analgesia following such procedures can be challenging. METHODS: The current study retrospectively reviews our experience over a 2.5 year period with thoracic epidural analgesia (TE), paravertebral blockade (PVB), and intravenous opioids delivered via patient-controlled analgesia (PCA) to provide postoperative analgesia. RESULTS: The study cohort included 30 patients (mean age = 15...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29033015/analyzing-effectiveness-of-routine-pleural-drainage-after-nuss-procedure-a-randomized-study
#5
Krystian Pawlak, Łukasz Gąsiorowski, Piotr Gabryel, Szymon Smoliński, Wojciech Dyszkiewicz
BACKGROUND: The routine use of postoperative pleural cavity drainage after the Nuss procedure is not widely accepted, and its limited use depends on experience. This study analyzed the influence of pleural drainage in the surgical treatment of patients with pectus excavatum on the prevention of pneumothorax and the efficacy of using drainage after a corrective operation. METHODS: From November 2013 to May 2015, 103 consecutive patients with pectus excavatum, aged 11 to 39 years, underwent surgical treatment by the Nuss procedure...
October 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29020617/live-imaging-reveals-that-the-first-division-of-differentiating-human-embryonic-stem-cells-often-yields-asymmetric-fates
#6
Katharine Brown, Kyle M Loh, Roel Nusse
How do stem cells respond to signals to initiate differentiation? Here, we show that, despite uniform exposure to differentiation-inducing extracellular signals, individual human embryonic stem cells (hESCs) respond heterogeneously. To track how hESCs incipiently exit pluripotency, we established a system to differentiate hESCs as single cells and conducted live imaging to track their very first cell division. We followed the fate of their earliest daughters as they remained undifferentiated or differentiated toward the primitive streak (the earliest descendants of pluripotent cells)...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29016121/synthesis-binding-mode-and-antihyperglycemic-activity-of-potent-and-selective-5-imidazol-2-yl-4-phenylpyrimidin-2-yl-2-2-pyridylamino-ethyl-amine-inhibitors-of-glycogen-synthase-kinase-3
#7
Allan S Wagman, Rustum S Boyce, Sean P Brown, Eric Fang, Dane Goff, Johanna M Jansen, Vincent P Le, Barry H Levine, Simon C Ng, Zhi-Jie Ni, John M Nuss, Keith B Pfister, Savithri Ramurthy, Paul A Renhowe, David B Ring, Wei Shu, Sharadha Subramanian, Xiaohui A Zhou, Cynthia M Shafer, Stephen D Harrison, Kirk W Johnson, Dirksen E Bussiere
In an effort to identify new antidiabetic agents, we have discovered a novel family of (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine analogues which are inhibitors of human glycogen synthase kinase 3 (GSK3). We developed efficient synthetic routes to explore a wide variety of substitution patterns and convergently access a diverse array of analogues. Compound 1 (CHIR-911, CT-99021, or CHIR-73911) emerged from an exploration of heterocycles at the C-5 position, phenyl groups at C-4, and a variety of differently substituted linker and aminopyridine moieties attached at the C-2 position...
October 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28945563/-the-myeloperoxidase-a-fine-strategist-facing-pathogenic-infections
#8
Manon Poret, Thanh Tran, Marie Villotte, Oliver Nüsse
No abstract text is available yet for this article.
August 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28929088/microbial-invasion-vs-tick-immune-regulation
#9
REVIEW
Daniel E Sonenshine, Kevin R Macaluso
Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28926811/towards-better-monitoring-of-technology-critical-elements-in-europe-coupling-of-natural-and-anthropogenic-cycles
#10
Philip Nuss, Gian Andrea Blengini
The characterization of elemental cycles has a rich history in biogeochemistry. Well known examples include the global carbon cycle, or the cycles of the 'grand nutrients' nitrogen, phosphorus, and sulfur. More recently, efforts have increased to better understand the natural cycling of technology critical elements (TCEs), i.e. elements with a high supply risk and economic importance in the EU. On the other hand, tools such as material-flow analysis (MFA) can help to understand how substances and goods are transported and accumulated in man-made technological systems ('anthroposphere')...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#11
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28893382/pain-and-sensory-disturbances-following-surgical-repair-of-pectus-carinatum
#12
Marie Veje Knudsen, Hans K Pilegaard, Kasper Grosen
BACKGROUND/PURPOSE: The purpose of this study was to assess the characteristics of persistent postoperative pain and sensory disturbances following surgical repair of pectus carinatum. METHODS: Using a prospective observational design, 28 patients were assessed before, 6 weeks and 6 months after a modified Ravitch operation for pectus carinatum. Postoperative pain was assessed using the Short Form McGill Pain Questionnaire. Sensory testing was conducted to detect brush-evoked allodynia and pinprick hyperalgesia...
August 25, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28886197/in-vivo-lineage-tracing-reveals-axin2-expressing-long-lived-cortical-thymic-epithelial-progenitors-in-the-postnatal-thymus
#13
Si Hui Tan, Roel Nusse
In the thymus, cortical and medullary thymic epithelial cells (TECs) are instrumental for generating a repertoire of functional T cells. Hence, there has been much interest in the ontogeny of TECs. While medullary TEC (mTEC) and bipotent progenitors have been identified, the existence of a cortical TEC (cTEC) progenitor remains ambiguous. In this study, we used lineage tracing based on a target gene of the Wnt pathway, Axin2. We found that Axin2 initially labels cells in both the cortical and medullary compartments...
2017: PloS One
https://www.readbyqxmd.com/read/28879663/road-side-drug-testing-an-evaluation-of-the-alere-dds%C3%A2-2-mobile-test-system
#14
Timothy P Rohrig, Christine M Moore, Kimberly Stephens, Kelsey Cooper, Cynthia Coulter, Tyson Baird, Margaux Garnier, Samuel Miller, James Tuyay, Kei Osawa, Joshua Chou, Carson Nuss, Jeff Collier, Karen Cudlin Wittman
The number of drivers using drugs has increased over the last few years, and is likely to continue its upward trend. Testing drivers for alcohol use is routine and standardized, but the same is not true for the identification of driving under the influence of drugs (DUID). The Drug Evaluation and Classification Program (DECP) was developed to train police officers to recognize the signs and symptoms of recent drug use and remains an invaluable program; however there are insufficient numbers of these highly trained drug recognition experts (DRE's) who are available to attend every potential drug involved traffic incident...
September 6, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28878918/development-of-harlequin-syndrome-following-placement-of-thoracic-epidural-anesthesia-in-a-pediatric-patient-undergoing-nuss-procedure
#15
Ashley Lefevre, Gregory Schnepper
We report the development of Harlequin Syndrome following thoracic epidural placement in a pediatric patient. Unilateral facial flushing with contralateral pallor and anhidrosis is the clinical presentation. This syndrome is typically benign. When related to regional anesthesia, treatment involves reducing the local anesthetic infusion or stopping it altogether.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28859507/association-between-low-barometric-pressure-and-completed-suicides
#16
Rif S El-Mallakh, Kanwar Brar, Claire Watkins, Sharon Nuss, Stephen S O'Connor, Yonglin Gao, Jesse H Wright
No abstract text is available yet for this article.
September 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28855092/extending-the-upper-temperature-range-of-gas-chromatography-with-all-silicon-microchip-columns-using-a-heater-clamp-assembly
#17
Abhijit Ghosh, Jacob E Johnson, Johnathan G Nuss, Brittany A Stark, Aaron R Hawkins, Luke T Tolley, Brian D Iverson, H Dennis Tolley, Milton L Lee
Miniaturization of gas chromatography (GC) instrumentation is of interest because it addresses current and future issues relating to compactness, portability and field application. While incremental advancements continue to be reported in GC with columns fabricated in microchips (referred to in this paper as "microchip columns"), the current performance is far from acceptable. This lower performance compared to conventional GC is due to factors such as pooling of the stationary phase in corners of non-cylindrical channels, adsorption of sensitive compounds on incompletely deactivated surfaces, shorter column lengths and less than optimum interfacing to injector and detector...
August 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28837456/temporal-healing-of-achilles-tendons-after-injury-in-rodents-depends-on-surgical-treatment-and-activity
#18
Benjamin R Freedman, Nabeel S Salka, Tyler R Morris, Pankti R Bhatt, Adam M Pardes, Joshua A Gordon, Courtney A Nuss, Corinne N Riggin, George W Fryhofer, Daniel C Farber, Louis Soslowsky
INTRODUCTION: Achilles tendon ruptures affect 15 of 100,000 women and 55 of 100,000 men each year. Controversy continues to exist regarding optimal treatment and rehabilitation protocols. The objective of this study was to investigate the temporal effects of surgical repair and immobilization or activity on Achilles tendon healing and limb function after complete transection in rodents. METHODS: Injured tendons were repaired (n = 64) or left nonrepaired (n = 64)...
September 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28827049/the-effect-of-thoracoscopy-upon-the-repair-of-pectus-excavatum
#19
Nicole Mennie, Geoff Frawley, Joe Crameri, Sebastian K King
BACKGROUND/AIMS: The Nuss procedure is the most commonly performed operation to correct pectus excavatum (PE). Thoracoscopic assistance has been anecdotally noted to improve the safety of this operative approach. This study aimed to compare complications and clinical outcomes before and after the introduction of thoracoscopy in a single-center. METHODS: A retrospective review was performed of all patients who underwent the Nuss procedure at The Royal Children's Hospital over an 11-year period (2005-2015), collecting data on all intra-operative and post-operative outcomes...
July 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28822540/life-threatening-complications-and-mortality-of-minimally-invasive-pectus-surgery
#20
André Hebra, Robert E Kelly, Marcelo M Ferro, Mustafa Yüksel, Jose Ribas M Campos, Donald Nuss
The prevalence and type of life-threatening complications related to the minimally invasive repair of pectus excavatum (MIRPE) and bar removal are unknown and underreported. The purpose of this communication is to make surgeons aware of the risk of these life threatening complications as well as the modifications which have been developed to prevent them. METHODS: Data related to life-threatening complications of Pectus Excavatum (PE) patients was obtained from four sources: 1. A survey of Chest Wall International Group (CWIG) surgeons who specialize in repairing congenital chest wall malformations, 2...
July 31, 2017: Journal of Pediatric Surgery
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