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https://www.readbyqxmd.com/read/29329915/observed-variation-in-n95-respirator-use-by-nurses-demonstrating-isolation-care
#1
Elizabeth L Beam, Elizabeth L Hotchkiss, Shawn G Gibbs, Angela L Hewlett, Peter C Iwen, Suzanne L Nuss, Philip W Smith
Video review and scoring was used to evaluate the behaviors of nurses wearing N95 filtering face piece respirators while providing isolation care in a simulated patient care environment. This study yielded a detailed description of behaviors related to N95 respirator use in a health care setting. Developing a more robust and systematic behavior analysis tool for use in demonstration, simulation, and clinical care would allow for improved respiratory protection of health care workers.
January 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29326102/collectively-improving-our-teaching-attempting-biology-department-wide-professional-development-in-scientific-teaching
#2
Melinda T Owens, Gloriana Trujillo, Shannon B Seidel, Colin D Harrison, Katherine M Farrar, Hilary P Benton, J R Blair, Katharyn E Boyer, Jennifer L Breckler, Laura W Burrus, Dana T Byrd, Natalia Caporale, Edward J Carpenter, Yee-Hung M Chan, Joseph C Chen, Lily Chen, Linda H Chen, Diana S Chu, William P Cochlan, Robyn J Crook, Karen D Crow, José R de la Torre, Wilfred F Denetclaw, Lynne M Dowdy, Darleen Franklin, Megumi Fuse, Michael A Goldman, Brinda Govindan, Michael Green, Holly E Harris, Zheng-Hui He, Stephen B Ingalls, Peter Ingmire, Amber R B Johnson, Jonathan D Knight, Gretchen LeBuhn, Terrye L Light, Candace Low, Lance Lund, Leticia M Márquez-Magaña, Vanessa C Miller-Sims, Christopher A Moffatt, Heather Murdock, Gloria L Nusse, V Thomas Parker, Sally G Pasion, Robert Patterson, Pleuni S Pennings, Julio C Ramirez, Robert M Ramirez, Blake Riggs, Rori V Rohlfs, Joseph M Romeo, Barry S Rothman, Scott W Roy, Tatiane Russo-Tait, Ravinder N M Sehgal, Kevin A Simonin, Greg S Spicer, Jonathon H Stillman, Andrea Swei, Leslie C Tempe, Vance T Vredenburg, Steven L Weinstein, Andrew G Zink, Loretta A Kelley, Carmen R Domingo, Kimberly D Tanner
Many efforts to improve science teaching in higher education focus on a few faculty members at an institution at a time, with limited published evidence on attempts to engage faculty across entire departments. We created a long-term, department-wide collaborative professional development program, Biology Faculty Explorations in Scientific Teaching (Biology FEST). Across 3 years of Biology FEST, 89% of the department's faculty completed a weeklong scientific teaching institute, and 83% of eligible instructors participated in additional semester-long follow-up programs...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29289666/efficacy-of-favipiravir-t-705-in-nonhuman-primates-infected-with-ebola-virus-or-marburg-virus
#3
Sandra L Bixler, Thomas M Bocan, Jay Wells, Kelly Wetzel, Sean Van Tongeren, Lian Dong, Nicole Lackemeyer, Ginger Donnelly, Lisa Cazares, Jonathan Nuss, Veronica Soloveva, Keith Koistinen, Lisa Welch, Carol Epstein, Li-Fang Liang, Dennis Giesing, Robert Lenk, Sina Bavari, Travis K Warren
Favipiravir is a broad-spectrum antiviral agent that has demonstrated efficacy against Ebola virus (EBOV) in rodents. However, there are no published reports of favipiravir efficacy for filovirus infection of nonhuman primates (NHPs). Here we evaluated the pharmacokinetic profile of favipiravir in NHPs, as well as in vivo efficacy against two filoviruses, EBOV and Marburg virus (MARV). While no survival benefit was observed in two studies employing once- or twice-daily oral dosing of favipiravir during EBOV infection of NHPs, an antiviral effect was observed in terms of extended time-to-death and reduced levels of viral RNA...
December 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29262368/single-molecule-imaging-of-wnt3a-protein-diffusion-on-living-cell-membranes
#4
Anna Lippert, Agnieszka A Janeczek, Alexandre Fürstenberg, Aleks Ponjavic, W E Moerner, Roel Nusse, Jill A Helms, Nicholas D Evans, Steven F Lee
Wnt proteins are secreted, hydrophobic, lipidated proteins found in all animals that play essential roles in development and disease. Lipid modification is thought to facilitate the interaction of the protein with its receptor, Frizzled, but may also regulate the transport of Wnt protein and its localization at the cell membrane. Here, by employing single-molecule fluorescence techniques, we show that Wnt proteins associate with and diffuse on the plasma membranes of living cells in the absence of any receptor binding...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29262339/regulation-of-h3k4me3-at-transcriptional-enhancers-characterizes-acquisition-of-virus-specific-cd8-t-cell-lineage-specific-function
#5
Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle L T Nguyen, Linden J Gearing, Thi H O Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nüssing, Georges Khoury, Damian F J Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner
Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that control these changes are largely unknown. Using ChIP-seq for specific histone post-translational modifications (PTMs), we mapped the dynamics of ∼25,000 putative CD8+ T cell transcriptional enhancers (TEs) differentially utilized during virus-specific T cell differentiation. Interestingly, we identified a subset of dynamically regulated TEs that exhibited acquisition of a non-canonical (H3K4me3+) chromatin signature upon differentiation...
December 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/29223667/selective-versus-routine-patch-metal-allergy-testing-to-select-bar-material-for-the-nuss-procedure-in-932-patients-over-10years
#6
Robert J Obermeyer, Sheema Gaffar, Robert E Kelly, M Ann Kuhn, Frazier W Frantz, Margaret M McGuire, James F Paulson, Cynthia S Kelly
AIM OF THE STUDY: The aim of the study was to determine the role of patch metal allergy testing to select bar material for the Nuss procedure. METHODS: An IRB-approved (11-04-WC-0098) single institution retrospective, cohort study comparing selective versus routine patch metal allergy testing to select stainless steel or titanium bars for Nuss repair was performed. In Cohort A (9/2004-1/2011), selective patch testing was performed based on clinical risk factors...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29210330/subcutaneous-local-anesthetic-infusion-could-eliminate-use-of-epidural-analgesia-after-the-nuss-procedure
#7
Sandra K Kabagambe, Laura F Goodman, Y Julia Chen, Benjamin A Keller, James C Becker, Gary W Raff, Rebecca A Stark, Jacob T Stephenson, Amy Rahm, Diana L Farmer, Shinjiro Hirose
AIM: To compare outcomes of continuous subcutaneous infusion of local anesthetic and epidural analgesia following the Nuss procedure. PATIENTS & METHODS: A retrospective chart review compared patients managed with subcutaneous local anesthetic infusion (n = 12) versus thoracic epidural (n = 19) following the Nuss procedure from March 2013 to June 2015. RESULTS: There was no difference in hospital length of stay or days on intravenous narcotics...
January 2018: Pain Management
https://www.readbyqxmd.com/read/29198628/revision-of-failed-prior-nuss-in-adult-patients-with-pectus-excavatum
#8
Awais Ashfaq, Staci Beamer, MennatAllah M Ewais, Jesse Lackey, Dawn Jaroszewski
BACKGROUND: Minimally invasive repair of pectus excavatum (MIRPE) has been extended to repair of defects in adults, with reported higher complication rates and outcome failures. The optimal revision for a prior failed MIRPE in an adult has not been identified. We review our experience for this adult population. METHODS: A retrospective review was performed of 129 patients (age ≥18 years) who underwent revision after a failed pectus excavatum (PE) repair from December 2010 through December 2016...
December 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29189368/opioid-prescribing-for-the-treatment-of-acute-pain-in-children-on-hospital-discharge
#9
Constance L Monitto, Aaron Hsu, Shuna Gao, Paul T Vozzo, Paul S Park, Deborah Roter, Gayane Yenokyan, Elizabeth D White, Deepa Kattail, Amy E Edgeworth, Kelly J Vasquenza, Sara E Atwater, Joanne E Shay, Jessica A George, Barbara A Vickers, Sabine Kost-Byerly, Benjamin H Lee, Myron Yaster
BACKGROUND: The epidemic of nonmedical use of prescription opioids has been fueled by the availability of legitimately prescribed unconsumed opioids. The aim of this study was to better understand the contribution of prescriptions written for pediatric patients to this problem by quantifying how much opioid is dispensed and consumed to manage pain after hospital discharge, and whether leftover opioid is appropriately disposed of. Our secondary aim was to explore the association of patient factors with opioid dispensing, consumption, and medication remaining on completion of therapy...
December 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29182681/using-13c-in-cattle-hair-to-trace-back-the-maize-level-in-the-feeding-regime-a-field-test
#10
Verena Hammes, Olaf Nüsse, Johannes Isselstein, Manfred Kayser
Sections from cattle hair serve as an isotopic archive-they contain information on the cattle diet from different time periods. We tested the reliability of 13C signatures (δ13C) in cattle tail switch hair to retrospectively trace back the annual dietary proportion of maize of different production systems without having to sample and analyze the feed. Furthermore, we investigated if differences in dietary proportion of maize during summer and winter feeding can be detected in a single tail switch hair by sampling hair only once a year...
2017: PloS One
https://www.readbyqxmd.com/read/29174271/effects-of-pulsed-electromagnetic-field-therapy-at-different-frequencies-and-durations-on-rotator-cuff-tendon-to-bone-healing-in-a-rat-model
#11
Julianne Huegel, Daniel S Choi, Courtney A Nuss, Mary C C Minnig, Jennica J Tucker, Andrew F Kuntz, Erik I Waldorff, Nianli Zhang, James T Ryaby, Louis J Soslowsky
BACKGROUND: Rotator cuff tears affect millions of individuals each year, often requiring surgical intervention. However, repair failure remains common. We have previously shown that pulsed electromagnetic field (PEMF) therapy improved tendon-to-bone healing in a rat rotator cuff model. The purpose of this study was to determine the influence of both PEMF frequency and exposure time on rotator cuff healing. METHODS: Two hundred ten Sprague-Dawley rats underwent acute bilateral supraspinatus injury and repair followed by either Physio-Stim PEMF or high-frequency PEMF therapy for 1, 3, or 6 hours daily...
November 22, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29162223/effects-of-pectus-excavatum-repair-on-right-and-left-ventricular-strain
#12
Chieh-Ju Chao, Dawn Jaroszewski, Michael Gotway, MennatAllah Ewais, Susan Wilansky, Steven Lester, Samuel Unzek, Christopher P Appleton, Hari P Chaliki, Brantley D Gaitan, Farouk Mookadam, Tasneem Z Naqvi
BACKGROUND: The cardiopulmonary benefits of pectus excavatum repair have been debated. Echocardiographic speckle-tracking strain and strain rate have been used to evaluate and detect subclinical myocardial dysfunction in patients receiving cardiotoxic chemotherapy, and patients with valvular heart disease. This technology was applied to evaluate the effects of pectus excavatum surgery on left ventricular (LV) and right ventricular (RV) function. METHODS: Speckle tracing strain evaluation was performed on intraoperative transesophageal echocardiographic images acquired immediately before and after Nuss repair in adult patients (aged 18 years or more) from 2011 to 2014...
November 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29158654/farmers-market-utilization-among-supplemental-nutrition-assistance-program-recipients-in-new-orleans-louisiana-preliminary-findings
#13
Henry Nuss, Meg Skizim, Hasheemah Afaneh, Lucio Miele, Melinda Sothern
Objective: Farmers' markets are increasingly being promoted as a means to provide fresh produce to poor and underserved communities. However, farmers' market (FM) use remains low among low-income patrons. The purpose of our study was to examine FM awareness and use, grocery shopping behaviors, and internet use among Supplemental Nutrition Assistance Program (SNAP) recipients. Design: A descriptive analysis of preliminary data was performed to evaluate quantitative baseline data among SNAP recipients between June and August 2016 in New Orleans, Louisiana (N=51)...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29156016/pectus-excavatum-repair-after-sternotomy-the-chest-wall-international-group-experience-with-substernal-nuss-bars
#14
Dawn E Jaroszewski, Paul J Gustin, Frank-Martin Haecker, Hans Pilegaard, Hyung Joo Park, Shao-Tao Tang, Shuai Li, Li Yang, Sadashige Uemura, Jose Ribas Milanez De Campos, Robert Obermeyer, Frazier W Frantz, Michele Torre, Lisa McMahon, Andre Hebra, Chih-Chun Chu, J Duncan Phillips, David M Notrica, Antonio Messineo, Robert Kelly, Mustafa Yüksel
OBJECTIVES: Patients with pectus excavatum (PE) after prior sternotomy for cardiac surgery present unique challenges for repair of PE. Open repairs have been recommended because of concerns about sternal adhesions and cardiac injury. We report a multi-institutional experience with repair utilizing substernal Nuss bars in this patient population. METHODS: Surgeons from the Chest Wall International Group were queried for experience and retrospective data on PE repair using sub-sternal Nuss bars in patients with a history of median sternotomy for cardiac surgery (November 2000 to August 2015)...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29152753/the-hospital-otolaryngologist-the-louisiana-state-university-experience
#15
Phillip G Allen, Laura T Hetzler, Daniel W Nuss, Rohan R Walvekar, Gretchen Penton, Elona Sharbaugh
OBJECTIVES/HYPOTHESIS: To describe the implementation and impact of a hospital otolaryngologist in an academic medical center setting. Our hypothesis was that the hospital otolaryngologist would increase productivity of the Louisiana State University (LSU) faculty otolaryngologists and provide more timely access to inpatient otolaryngology services. STUDY DESIGN: Retrospective clinical and administrative database review. METHODS: A comparative database review was performed with data from the year predating the initiation of the hospitalist program (2013) to the first full year after initiation of the program (2014)...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29078605/uniportal-nuss-procedure-for-pectus-excavatum-where-to-place-the-camera-but-we-ve-always-done-it-this-way
#16
Ivan Schewitz
This study was stimulated by the increasing use of uniportal thoracoscopic surgery. If a lobectomy can be performed through one small incision why not the much simpler Nuss procedure? The Nuss procedure was performed with the use of the surgical incision for the camera. Initially the patient was positioned so that the standard site for the camera could be utilized. Once it become obvious that the uniportal approach worked the patient was positioned in the middle of the table. In all cases the uniportal approach in my hands was easy and made the operation less cumbersome...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29061495/femoral-osteochondroplasty-can-be-performed-effectively-without-the-risk-of-avascular-necrosis-or-femoral-neck-fractures-in-an-experimental-ovine-fai-model
#17
F Schmaranzer, L Arendt, T D Lerch, S D Steppacher, K Nuss, N Wolfer, H E Dawson, B von Rechenberg, P R Kircher, M Tannast
OBJECTIVE: The experimental induction of cam-type femoroacetabular impingement (FAI) in sheep is established. To tap the full potential of this ovine model, one should be able to perform a femoral osteochondroplasty safely. This study was based on previous cadaver experiments on the blood supply to the ovine femoral head and on the biomechanical strength of the proximal femur following offset creation. We hypothesized that offset creation in this ovine FAI model does not lead to (1) avascular necrosis (AVN) of the ovine femoral head or (2) iatrogenic femoral neck fractures and (3) can be performed effectively...
October 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29052000/results-of-pectus-excavatum-correction-using-a-minimally-invasive-approach-with-subxyphoid-incision-and-three-point-fixation
#18
Sheldon J Bond, Emily Rapstine, Jordan M Bond
OBJECTIVES: This study reviews the results of our previously described modification of the minimally invasive (Nuss) procedure for correction of pectus excavatum. It utilizes a subxyphoid incision with central fixation to maximize safe bar passage and minimize bar displacement. METHODS: Consecutive patients corrected with the modified Nuss procedure between 2010 and 2015 form the basis of this study. RESULTS: During the study period, 73 patients had correction of their pectus excavatum by the modified Nuss procedure, utilizing subxyphoid incision and central fixation...
October 19, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29033723/postoperative-pain-management-in-patients-undergoing-thoracoscopic-repair-of-pectus-excavatum-a-retrospective-analysis-of-opioid-consumption-and-adverse-effects-in-adolescents
#19
Ralph Beltran, Giorgio Veneziano, Tarun Bhalla, Brian Kenney, Dmitry Tumin, Bruno Bissonnette, Joseph D Tobias
INTRODUCTION: Although the Nuss procedure provides excellent cosmetic results for the correction of pectus excavatum, the provision of analgesia following such procedures can be challenging. METHODS: The current study retrospectively reviews our experience over a 2.5 year period with thoracic epidural analgesia (TE), paravertebral blockade (PVB), and intravenous opioids delivered via patient-controlled analgesia (PCA) to provide postoperative analgesia. RESULTS: The study cohort included 30 patients (mean age = 15...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29033015/analyzing-effectiveness-of-routine-pleural-drainage-after-nuss-procedure-a-randomized-study
#20
Krystian Pawlak, Łukasz Gąsiorowski, Piotr Gabryel, Szymon Smoliński, Wojciech Dyszkiewicz
BACKGROUND: The routine use of postoperative pleural cavity drainage after the Nuss procedure is not widely accepted, and its limited use depends on experience. This study analyzed the influence of pleural drainage in the surgical treatment of patients with pectus excavatum on the prevention of pneumothorax and the efficacy of using drainage after a corrective operation. METHODS: From November 2013 to May 2015, 103 consecutive patients with pectus excavatum, aged 11 to 39 years, underwent surgical treatment by the Nuss procedure...
October 13, 2017: Annals of Thoracic Surgery
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