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Adri D Prasetyo, Welf Prager, Mark G Rubin, Ernesto A Moretti, Andreas Nikolis
BACKGROUND: Cohesive monophasic polydensified fillers show unique viscoelastic properties and variable density of hyaluronic acid, allowing for a homogeneous tissue integration and distribution of the material. OBJECTIVE: The aim of this paper was to review the clinical data regarding the performance, tolerability, and safety of the Belotero(®) fillers for soft-tissue augmentation and rejuvenation. METHODS: A literature search was performed up until May 31, 2015 to identify all relevant articles on Belotero(®) fillers (Basic/Balance, Hydro, Soft, Intense, Volume) and equivalent products (Esthélis(®), Mesolis(®), Fortélis(®), Modélis(®))...
2016: Clinical, Cosmetic and Investigational Dermatology
Patrick Micheels, Stéphanie Besse, Didier Sarrazin
BACKGROUND: Hyaluronic acid (HA) fillers are commonly used for enhancement of lips, and for softening fine lines and correcting skin depressions. OBJECTIVE: This study sought to investigate whether the Vycross<sup>™</sup> technology used for Volbella<sup>™</sup> gel resulted in a cohesive gel, as documented in our previous studies with three other HA fillers (Restylane<sup>®</sup> NASHA<sup>™</sup> [Q-MED, Uppsala, Sweden], Esthélis<sup>®</sup> Basic CPM™ [Anteis SA, Geneva, Switzerland], and Juvéderm<sup>®</sup> Ultra 3 using Hylacross technology [Allergan, Irvine, CA, USA])...
September 1, 2016: Journal of Drugs in Dermatology: JDD
Annie Chiu, Sabrina Fabi, Steven Dayan, Alessandra Nogueira
The shape and fullness of the lips have a significant role in facial aesthetics and outward appearance. The corrective needs of a patient can range from a subtle enhancement to a complete recontouring including correction of perioral rhytides. A comprehensive understanding of the lower face anatomical features and injection site techniques are foundational information for injectors. Likewise, the choice of filler material contributes to the success of the injection techniques used, and facilitates a safe, effective, and natural appearing outcome...
September 1, 2016: Journal of Drugs in Dermatology: JDD
James A Burns, Jaime L Botelho, Jonathan I Bell, William Faquin, Gerardo Lopez-Guerra, Jerome L Ackerman, James B Kobler
OBJECTIVES: Aortic homografts integrate well with laryngeal tissue when used in reconstructive surgery. It was hypothesized that a paste of aortic homograft, rich in slow-to-degrade elastin, would compare favorably in residence time and biocompatibility to predicate materials used for vocal fold injection-medialization. METHODS: An injectable aorta paste (AP) was made by pulverizing aortic homografts at -196°C (cryomilling). To assess residence time and biocompatibility, 0...
November 2016: Annals of Otology, Rhinology, and Laryngology
Karol A Gutowski
Hyaluronic acid soft tissue fillers include a range of products (Juvederm Ultra, Juvederm Ultra Plus, Voluma, Restylane Silk, Restylane, Restylane Lyft, and Belotero Balance) that are used commonly for facial rejuvenation and enhancement of facial features. Although these products are similar in many ways, they are not interchangeable and have unique characteristics that need to be considered. Injection sites and techniques for facial rejuvenation are discussed.
July 2016: Clinics in Plastic Surgery
Robert A Weiss, Amir Moradi, David Bank, Julius Few, John Joseph, Jeffrey Dover, Xiaoming Lin, Alessandra Nogueira, Jay Mashburn
BACKGROUND: Aging effects, such as facial flatness, increased tissue laxity, and soft tissue descent and deflation, contribute to midface deficiency. OBJECTIVE: To evaluate whether large gel particle hyaluronic acid with lidocaine (LGP-HAL) is more effective in the treatment of midface deficiencies than no treatment. MATERIALS AND METHODS: Subjects with mild to substantial loss of midface fullness were randomized 3:1 to LGP-HAL (Restylane Lyft; Galderma Laboratories, L...
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Patrick Micheels, Didier Sarazin, Christian Tran, Denis Salomon
BACKGROUND: The mechanical, rheological, and pharmacological properties of hyaluronic acid (HA) gels differ by their proprietary crosslinking technologies.<BR /> OBJECTIVE: To examine the different properties of a range of HA gels using simple and easily reproducible laboratory tests to better understand their suitability for particular indications.<BR /> METHODS AND MATERIALS: Hyaluronic acid gels produced by one of 7 different crosslinking technologies were subjected to tests for cohesivity, resistance to stretch, and microscopic examination...
May 1, 2016: Journal of Drugs in Dermatology: JDD
Tai Kyung Noh, Hye Rim Moon, Ji Su Yu, Sung Eun Chang, Ik Jun Moon, Sun Young Choi, Won Jong Oh, Chong Hyun Won, Beom Joon Kim, Yang Won Lee
BACKGROUND: A previous 6-month study using a more highly concentrated novel hyaluronic acid (HA) filler, PP-501-B, found nasolabial fold (NLF) improvements with increased tolerability. OBJECTIVE: We investigated the long-term efficacy, durability and safety of PP-501-B in the correction of NLFs. METHODS: Subjects completing the initial six-month study were enrolled in this 24-month, randomized, multicenter, double-blind, split-face, extension study...
April 28, 2016: Journal of Dermatological Treatment
Yan Wu, Nan Sun, Yue Xu, Huixian Liu, Shaomin Zhong, Liyang Chen, Dong Li
Hyaluronic acid fillers are used to improve the appearance of nasolabial folds (NLF). This study aimed to compare the efficacy, safety, and durability of a new hyaluronic acid gel (BioHyalux) versus Restylane for the correction of NLF. This was a multicenter, double-blinded, randomized, controlled, non-inferiority clinical trial involving 88 subjects with moderate to severe NLF. Subjects were randomized to BioHyalux and Restylane on either sides of the NLF. NLF was assessed before and right after injection, and at 1 week, 1, 3, and 6 months...
April 2016: Archives of Dermatological Research
Hong Jin Joo, Young Jun Woo, Jung Eun Kim, Beom Joon Kim, Hoon Kang
BACKGROUND: Hyaluronic acid dermal fillers are most frequently used for unwanted wrinkles. Recently, lidocaine has been incorporated into hyaluronic acid fillers to reduce injection discomfort. METHODS: A randomized, multicenter, double-blind, intraindividual trial was designed to compare a new lidocaine-containing monophasic hyaluronic acid filler (Neuramis Deep Lidocaine) with a lidocaine-containing biphasic hyaluronic acid filler (Restylane Perlane-L) in moderate to severe nasolabial folds...
March 2016: Plastic and Reconstructive Surgery
Hervé Raspaldo, Jonquille Chantrey, Lakhdar Belhaouari, David Eccleston, Roy Saleh, Raj Acquilla, Diane K Murphy
BACKGROUND: Juvéderm® Volbella® with Lidocaine is a hyaluronic acid filler suited for lip enhancement. OBJECTIVE: Evaluate the safety and effectiveness of Juvéderm Volbella with Lidocaine versus non-animal stabilized hyaluronic acid with lidocaine (Restylane-L®). METHODS: This study randomized 280 subjects desiring lip enhancement to Juvéderm Volbella with Lidocaine or Restylane-L. Investigators rated outcomes using Allergan's Lip Fullness Scale (LFS), Perioral Lines Severity Scale, and Oral Commissures Severity Scale...
December 2015: Journal of Drugs in Dermatology: JDD
Katarina L M Edsman, Åsa M Wiebensjö, Anna Maria Risberg, Jan Åke Öhrlund
BACKGROUND: Cohesion is described as the force between particles of the same substance that acts to unite them. Contrary to rheology, there are currently no ready-made instruments designed to measure cohesion, or methods which could be easily adapted to gels. To study and compare the possible clinical effects from the cohesive properties of a gel, it is necessary to standardize the definition and measurement of cohesion. OBJECTIVE: The purpose of this study was to develop and evaluate methods for measuring cohesion...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
J Åke Öhrlund, Katarina L M Edsman
BACKGROUND: The terms "biphasic" and "monophasic" have been used frequently as a means of differentiating hyaluronic acid (HA) fillers. This type of categorization is based on misinterpretations of the term "phase" and provides no help to the practitioner when selecting the most appropriate product for each indication, patient, and injection technique. OBJECTIVE: The purpose of this study was to analyze the properties of 2 HA filler families; Juvederm (JUV) (Allergan), often stated to be monophasic and Restylane (RES) (Galderma), often stated to be biphasic, and discuss what properties may have led to the use of the terms monophasic and biphasic...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Changsik Pak, Jihoon Park, Jinmyung Hong, Jaehoon Jeong, Saik Bang, Chan Yeong Heo
BACKGROUND: We conducted this clinical study to compare the efficacy and safety between Neuramis Deep and Restylane in the correction of nasolabial folds. METHODS: In this phase III, randomized, multi-center, double-masked, matched-pairs, active-controlled trial ( Identifier: NCT01585220), we evaluated a total of 67 subjects (n=67). All the subjects underwent Neuramis Deep treatment on one side and Restylane on the contralateral side of the bilateral nasolabial folds at a ratio of 1:1...
November 2015: Archives of Plastic Surgery
Marina Landau, Steven Fagien
Loss of viscoelasticity is one of the primarily signs of skin aging, followed by appearance of visible wrinkles. Hyaluronic acid (HA)-based fillers are widely used to fill wrinkles and compensate for volume loss. Recent clinical observations demonstrate persistence of the filling effect longer than the biological availability of the filler. Stimulation of new collagen by cross-linked HA and up-regulation of elastin have been suggested as possible explanation to this observation and have been supported experimentally...
November 2015: Plastic and Reconstructive Surgery
Vince Bertucci, Carrie B Lynde
BACKGROUND: Soft-tissue augmentation with hyaluronic acid (HA) fillers has become one of the most popular cosmetic procedures performed. HA fillers represent safe and commonly used fillers. Several different HA fillers are available. The differences lie in the manufacturing process, allowing for tailored uses. A small-particle HA with lidocaine (SP-HAL; Restylane Silk; Galderma, Uppsala, Sweden) was approved by the US Food and Drug Administration in June 2014 but has been available for many years in Canada as Restylane Fine Lines and in Europe as Restylane Vital...
November 2015: Plastic and Reconstructive Surgery
Connie Brennan
Treatment guidelines are a crucial part of every medical aesthetic practice and must be in place before utilizing aesthetic medical injectables. An "Aesthetic Policy and Procedure Manual" features specific details (e.g., patient assessment, indication, contraindications, warnings and precautions, injection techniques, documentation, etc.) around dermal fillers (e.g., Restylane, Juvéderm, Voluma), hyaluronidase, neurotoxins (e.g., Botox Cosmetic, Dysport, and Xeomin) and Sculptra. This article describes why an "Aesthetic Policy and Procedure" manual is a necessary tool in every aesthetic provider's armamentarium, what it is composed of, as well as how these guidelines serve as a protective mechanism for the aesthetic provider's clinic if legal action is brought against their staff, their medical director, and/or their clinic...
July 2015: Plastic Surgical Nursing
Yeon Soo Kim, Jae Won Choi, Ju-Kyeong Park, Yoo Suk Kim, Hyun Jung Kim, Yoo Seob Shin, Chul-Ho Kim
CONCLUSION: The results of the present investigation suggest that modification of HA could improve efficiency and durability in augmentation laryngoplasty. OBJECTIVES: Injection laryngoplasty (IL) is one of the most suitable options for treatment of glottic insufficiency, which is caused by vocal fold (VF) paralysis, atrophy, or scarring. Hyaluronic acid (HA) is a widely used material for VF injection. This study was intended to evaluate the durability and efficiency of HA of different particle sizes for VF augmentation...
2015: Acta Oto-laryngologica
Bong Moo Lee, Dong Gil Han, Won Seok Choi
BACKGROUND: Morphological changes that accompany aging, such as wrinkles and skin laxity, are particularly prominent on facial skin. Recently, facial rejuvenation using the hydrofilling effect of hyaluronic acid (HA) filler has been employed for improvement of skin texture. In this study, we studied rejuvenating effects of stabilized HA (Restylane Vital) through direct intradermal injections. METHODS: A total of 30 female patients underwent a series of procedures on face, including three sessions at intervals of four weeks...
May 2015: Archives of Plastic Surgery
Hervé Raspaldo, Jonquille Chantrey, Lakdhar Belhaouari, Roy Saleh, Diane K Murphy
BACKGROUND: Juvéderm Volbella with Lidocaine is a new hyaluronic acid dermal filler. METHODS: In this prospective, randomized, multicenter study, 280 subjects desiring lip volume enhancement were treated with Juvéderm Volbella with Lidocaine or Restylane-L. Investigators rated treatment outcomes on Allergan's Lip Fullness Scale, Perioral Lines Scale, and Oral Commissures Severity Scale. A blinded independent central reviewer (ICR) assessed 3-dimensional digital photographs using these scales...
March 2015: Plastic and Reconstructive Surgery. Global Open
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