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https://www.readbyqxmd.com/read/29149845/early-nutritional-programming-affects-liver-transcriptome-in-diploid-and-triploid-atlantic-salmon-salmo-salar
#1
L M Vera, C Metochis, J F Taylor, M Clarkson, K H Skjærven, H Migaud, D R Tocher
BACKGROUND: To ensure sustainability of aquaculture, plant-based ingredients are being used in feeds to replace marine-derived products. However, plants contain secondary metabolites which can affect food intake and nutrient utilisation of fish. The application of nutritional stimuli during early development can induce long-term changes in animal physiology. Recently, we successfully used this approach to improve the utilisation of plant-based diets in diploid and triploid Atlantic salmon...
November 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29149628/multiplex-taqman-locked-nucleic-acid-real-time-pcr-for-the-differential-identification-of-various-meat-and-meat-products
#2
Rusu Xu, Shuang Wei, Guangbiao Zhou, Jiao Ren, Zhongyong Liu, Shuze Tang, Peter C K Cheung, Xiyang Wu
Meat adulteration incidents have been reported frequently over the past few years, and the corresponding traceability issues attracted much more attention due to the customer's demands and administration's responsibility. Therefore, it is important to develop high-throughput and rapid detection methods to identify the specific sources from meat samples. In this study, a multiplex TaqMan locked nucleic acid real-time polymerase chain reaction assay (MLNA-RT-PCR) was developed to simultaneously detect multiple meat sources (duck, pork, beef and chicken)...
November 14, 2017: Meat Science
https://www.readbyqxmd.com/read/29148591/statistical-modelling-of-sea-lice-count-data-from-salmon-farms-in-the-faroe-islands
#3
H Gislason
Fiskaaling regularly counts the number of sea lice in the attached development stages (chalimus, mobiles and adult) for the salmon farms in the Faroe Islands. A statistical model of the data is developed. In the model, the sea-lice infection is represented by the chalimus (or mobile) lice developing into adult lice and is used to simulate past and current levels of adult lice-including treatments-as well as to predict the adult sea lice level 1-2 months into the future. Time series of the chalimus and adult lice show cross-correlations that shift in time and grow in size with temperature...
November 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29148584/metabolic-effects-of-p-p-dde-on-atlantic-salmon-hepatocytes
#4
Pål A Olsvik, Liv Søfteland
Decades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p'-DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects. This study aimed at examining the impact of p,p'-DDE on Atlantic salmon. Primary hepatocytes were exposed to four concentrations of p,p'-DDE (0.1, 1, 10, 100 μm) for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcription and metabolomics profiling (100 μm)...
November 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29148583/study-of-the-hooking-behaviour-of-lepeophtheirus-salmonis-kr%C3%A3-yer-1837-copepodids-on-atlantic-salmon-salmo-salar-l-using-a-novel-in%C3%A2-vivo-test-system
#5
C Delfosse, C Lafont-Lecuelle, H Barthélémy, C Chabaud, E Teruel, C Bienboire-Frosini, P Pageat
The screening of putative semiochemicals involved in the interaction between Lepeophtheirus salmonis copepodid and the Atlantic salmon could be used to develop methods to prevent infestation. A bioassay was designed to evaluate the attractiveness of Atlantic salmon for L. salmonis copepodids by counting the number of hooked parasites. A salmon was bathed in a tank with 60 copepodids during 45 min. The salmon was humanely killed and its body was scrubbed above a plastic bag. The content of the bag was filtered to count the number of hooked parasites...
November 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29147588/diagnostic-challenge-a-report-of-two-adult-onset-still-s-disease-cases
#6
Sakunee Niranvichaiya, Daranporn Triwongwaranat
This study reports two adult-onset Still's disease (AOSD) cases that met both Yamaguchi's and Fautrel's criteria and that presented with notable clinical manifestations. One case presented with atypical dermographism-like rash with an extremely high ferritin level. The other case presented with typical salmon-pink maculopapular rash but had atypical positive rheumatoid factor. This suggests that although negative rheumatoid factor is one of the criteria used for the diagnosis of AOSD, a positive rheumatoid factor result does not exclude AOSD...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29146040/-effectiveness-therapeutic-maintenance-and-reasons-for-stopping-tocilizumab-tcz-a-retrospective-and-monocentric-study-in-88%C3%A2-patients-followed-for-rheumatoid-arthritis-ra-at-the-reims-university-hospital
#7
Clément Chopin, Loïc Pauvelle, Sarah Jaulerry, Pascal Brochot, Jean-Paul Eschard, Jean-Hugues Salmon
OBJECTIVE: Study the therapeutic maintenance, efficacy and reasons for tocilizumab stop in daily practice. PATIENTS AND METHODS: A monocentric, retrospective study of patients treated for rheumatoid arthritis who received at least one TCZ infusion between January 2009 and December 2015. Therapeutic maintenance was evaluated using the Kaplan-Meier method. The efficacy of TCZ was measured by DAS28 and the EULAR response. Reasons for stopping and new treatment lines were also collected...
October 18, 2017: Thérapie
https://www.readbyqxmd.com/read/29143962/comparison-of-gene-expression-in-post-smolt-atlantic-salmon-challenged-by-lf-89-like-and-em-90-like-piscirickettsia-salmonis-isolates-reveals-differences-in-the-immune-response-associated-with-pathogenicity
#8
M Rozas-Serri, A Peña, G Arriagada, R Enríquez, L Maldonado
Piscirickettsiosis is the main bacterial disease affecting the Chilean salmon farming industry and is responsible for high economic losses. The aim of this study was to describe and comparatively quantify the immune response of post-smolt Atlantic salmon infected by cohabitation with fish bearing LF-89-like and EM-90-like Piscirickettsia salmonis. The expression of 17 genes related to the immune response was studied in head kidney from cohabitant fish by RT-qPCR. Our results at the transcriptomic level suggest that P...
November 16, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29143947/connexin-30-is-expressed-in-a-subtype-of-mouse-brain-pericytes
#9
Noémie Mazaré, Alice Gilbert, Anne-Cécile Boulay, Nathalie Rouach, Martine Cohen-Salmon
Pericytes are mural cells of blood microvessels which play a crucial role at the neurovascular interface of the central nervous system. They are involved in the regulation of blood-brain barrier integrity, angiogenesis, clearance of toxic metabolites, capillary hemodynamic responses, and neuroinflammation, and they demonstrate stem cell activity. Morphological and molecular studies to characterize brain pericytes recently pointed out some heterogeneity in pericyte population. Nevertheless, a clear definition of pericyte subtypes is still lacking...
November 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29143199/cone-beam-ct-in-paediatric-dentistry-dimitra-project-position-statement
#10
REVIEW
Anne Caroline Oenning, Reinhilde Jacobs, Ruben Pauwels, Andreas Stratis, Mihaela Hedesiu, Benjamin Salmon
DIMITRA (dentomaxillofacial paediatric imaging: an investigation towards low-dose radiation induced risks) is a European multicenter and multidisciplinary project focused on optimizing cone-beam CT exposures for children and adolescents. With increasing use of cone-beam CT for dentomaxillofacial diagnostics, concern arises regarding radiation risks associated with this imaging modality, especially for children. Research evidence concerning cone-beam CT indications in children remains limited, while reports mention inconsistent recommendations for dose reduction...
November 15, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29140708/role-of-vapor-mass-transfer-in-flow-coating-of-colloidal-dispersions-in-the-evaporative-regime
#11
Charles Loussert, Frédéric Doumenc, Jean-Baptiste Salmon, Vadim S Nikolayev, Beatrice Guerrier
In flow-coating processes at low substrate velocity, solvent evaporation occurs during the film withdrawal and the coating process yields directly a dry deposit. In this regime, often referred to as the evaporative regime, several works performed on blade-coating-like confiurations have reported a deposit thickness hd proportional to the inverse of the substrate velocity V . Such a scaling can be easily derived from simple mass conservation laws, assuming that evaporation occurs on a constant distance, referred to as the evaporation length, noted Lev in the present paper and of the order of the meniscus size...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29138002/the-mechanism-of-hdea-unfolding-and-chaperone-activation
#12
Loïc Salmon, Frederick Stull, Sabrina Sayle, Claire Cato, Şerife Akgül, Linda Foit, Logan S Ahlstrom, Elan Z Eisenmesser, Hashim M Al-Hashimi, James C A Bardwell, Scott Horowitz
HdeA is a periplasmic chaperone that is rapidly activated upon shifting the pH to acidic conditions. This activation is thought to involve monomerization of HdeA. There is evidence that monomerization and partial unfolding allow the chaperone to bind to proteins denatured by low pH thereby protecting them from aggregation. We analyzed the acid-induced unfolding of HdeA using NMR spectroscopy and fluorescence measurements, and obtained experimental evidence suggesting a complex mechanism in HdeA's acid-induced unfolding pathway, as previously postulated from molecular dynamics simulations...
November 11, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29136724/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-renal-impairment-of-multiple-myeloma
#13
(no author information available yet)
Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Although the classic Durie-Salmon staging system could be still used in clinical practice, it may miss out some patients with renal impairment. For evaluations of RI in MM patients with CKD, it's recommended to assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29136366/use-of-an-efficient-measurement-uncertainty-approach-to-compare-room-temperature-and-cryogenic-sample-processing-in-the-analysis-of-chemical-contaminants-in-foods
#14
Lijun Han, Steven J Lehotay, Yelena Sapozhnikova
In this study, analytical results were compared when using different approaches to bulk food sample comminution, consisting of a vertical chopper (Blixer(®)) at room temperature and at dry ice cryogenic conditions, followed by further subsample processing (20 g) using liquid nitrogen cryogenic conditions (cryomill). Analysis of the 43 targeted spiked and incurred contaminants in a food mixture consisting of equal parts orange, apple, kale, salmon, and croaker involved QuEChERS with automated mini-column solid-phase extraction (known as ITSP) cleanup followed by low pressure gas chromatography - tandem mass spectrometry (LPGC-MS/MS)...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29132593/the-impact-of-helicopter-emergency-medical-service-night-operations-in-south-east-england
#15
Leigh Curtis, Mark Salmon, Richard M Lyon
OBJECTIVE: This study sought to assess the impact of a helicopter emergency medical service (HEMS) capable of night operations. METHODS: This is a retrospective case review of all night HEMS missions attended by a charity air ambulance service in South East England over a 2-year period (October 1, 2013, to October 1, 2015). RESULTS: During the 2-year trial period, the HEMS service undertook a total of 5,004 missions and attended to 3,728 patients...
November 2017: Air Medical Journal
https://www.readbyqxmd.com/read/29128493/molecular-characterization-of-a-cc-motif-chemokine-19-like-gene-in-ayu-plecoglossus-altivelis-and-its-role-in-leukocyte-trafficking
#16
Feng Chen, Xin-Jiang Lu, Li Nie, Ying-Jun Ning, Jiong Chen
The CC motif chemokine 19 (CCL19) functions in acute inflammation by recruiting lymphocytes and other cells. However, CCL19 has only been investigated in few fish species. In this study, we characterized a CCL19-like molecule (PaCCL19l) in ayu (Plecoglossus altivelis), a teleost fish. Sequence analysis revealed that PaCCL19l was most closely related to Atlantic salmon (Salmon salar) CCL19l1, which belonged to the fish CCL19a.1 subcluster. PaCCL19l was constitutively expressed in the tested ayu tissues and peripheral blood mononuclear cells (PBMCs), with the highest transcript level in PBMCs...
November 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29127669/conserving-connectivity-human-influence-on-subsidy-transfer-and-relevant-restoration-efforts
#17
REVIEW
Emily V Buckner, Daniel L Hernández, Jameal F Samhouri
Conservation efforts tend to focus on the direct impacts humans have on their surrounding environment; however there are also many ways in which people indirectly affect ecosystems. Recent research on ecological subsidies-the transfer of energy and nutrients from one ecosystem to another-has highlighted the importance of nutrient exchange for maintaining productivity and diversity at a landscape scale, while also pointing toward the fragility of ecotones and vulnerability of subsidies to human activities. We review the recent literature on landscape connectivity and ecosystem subsidies from aquatic systems to terrestrial systems...
November 10, 2017: Ambio
https://www.readbyqxmd.com/read/29124111/potential-implications-of-practice-effects-in-alzheimer-s-disease-prevention-trials
#18
Diane M Jacobs, M Colin Ard, David P Salmon, Douglas R Galasko, Mark W Bondi, Steven D Edland
Introduction: Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of practice on trial outcome. Methods: We investigated the potential implications of PEs in Alzheimer's disease prevention trials using placebo arm data from the Alzheimer's Disease Cooperative Study donepezil/vitamin E trial in mild cognitive impairment...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29124105/measuring-brain-synaptic-vesicle-protein-2a-with-positron-emission-tomography-and-18-f-ucb-h
#19
Mohamed Ali Bahri, Alain Plenevaux, Joël Aerts, Christine Bastin, Guillaume Becker, Joël Mercier, Anne Valade, Tim Buchanan, Nathalie Mestdagh, Didier Ledoux, Alain Seret, André Luxen, Eric Salmon
Introduction: Brain distribution of synaptic vesicle protein 2A was measured with fluorine-18 UCB-H ([(18)F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29122808/study-design-and-protocol-for-a-mixed-methods-evaluation-of-an-intervention-to-reduce-and-break-up-sitting-time-in-primary-school-classrooms-in-the-uk-the-class-pal-physically-active-learning-programme
#20
Ash C Routen, Stuart J H Biddle, Danielle H Bodicoat, Lorraine Cale, Stacy Clemes, Charlotte L Edwardson, Cris Glazebrook, Deirdre M Harrington, Kamlesh Khunti, Natalie Pearson, Jo Salmon, Lauren B Sherar
INTRODUCTION: Children engage in a high volume of sitting in school, particularly in the classroom. A number of strategies, such as physically active lessons (termed movement integration (MI)), have been developed to integrate physical activity into this learning environment; however, no single approach is likely to meet the needs of all pupils and teachers. This protocol outlines an implementation study of a primary school-based MI intervention: CLASS PAL (Physically Active Learning) programme...
November 8, 2017: BMJ Open
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