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https://www.readbyqxmd.com/read/28523416/utility-of-ct-oral-contrast-administration-in-the-emergency-department-of-a-quaternary-oncology-hospital-diagnostic-implications-turnaround-times-and-assessment-of-ed-physician-ordering
#1
Corey T Jensen, Katherine J Blair, Ott Le, Jia Sun, Wei Wei, Brinda Rao Korivi, Ajaykumar C Morani, Nicolaus A Wagner-Bartak
PURPOSE: To compare studies with and without oral contrast on performance of multidetector computed tomography (CT) and the order to CT examination turnaround time in cancer patients presenting to the emergency department (ED). To the best of our knowledge, oral contrast utility has not previously been specifically assessed in cancer patients presenting to the emergency department. MATERIALS & METHODS: Retrospective review of CT abdomen examinations performed in oncology patients presenting to the emergency department during one month...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28511107/frequent-emergency-department-presentations-among-people-who-inject-drugs-a-record-linkage-study
#2
Dhanya Nambiar, Mark Stoové, Paul Dietze
BACKGROUND: People who inject drugs (PWID) have been described as frequent users of health services such as emergency departments (EDs), however few studies have described demographic factors, patterns of substance use and previous health service use associated with frequent use of EDs in this population. METHODS: Using a combination of self-reported data from a cohort of PWID and administrative ED data obtained through record linkage, we identified longitudinal factors associated with the use of ED services...
May 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28501258/impact-of-hospital-admission-for-patients-with-transient-ischemic-attack
#3
Eric M Cheng, Laura J Myers, Stefanie Vassar, Dawn M Bravata
OBJECTIVES: To determine the impact of admission among transient ischemic attack (TIA) patients in the emergency department (ED). STUDY DESIGN: Retrospective cohort study using national Veterans Health Administration data (2008). METHODS: We first analyzed whether admitted patients were discharged from the hospital with a diagnosis of TIA. We then analyzed whether admission was associated with a composite outcome (new stroke, new myocardial infarction, or death in the year after TIA) using multivariate logistic regression modeling with propensity score matching...
May 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28501069/emergency-department-utilization-related-to-dental-conditions-and-distribution-of-dentists-nebraska-2011-2013
#4
Sankeerth Rampa, Fernando A Wilson, Rajvi Wani, Veerasathpurush Allareddy
PURPOSE: This study aims to provide estimates of hospital-based emergency department (ED) visits due to dental conditions in Nebraska and to examine patient-related characteristics associated with ED charges. In addition, this study provides dental-related ED visits and distribution of dentists by county. METHODS: For the study, we used the State Emergency Department Database for Nebraska for the years 2011 through 2013 and the Health Resources and Services Administration's Area Health Resource File...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28500651/predictors-of-response-in-emergency-department-patients-receiving-intravenous-opioids-for-severe-pain
#5
Jacob A Radcliff, Rachel M Rafeq, Jane F Bowen, Laura Pontiggia, Sanchita Sen
OBJECTIVE: The primary objective of this study was to identify significant environmental and patient characteristics of emergency department (ED) patients who responded to intravenous (IV) hydromorphone and IV morphine for severe pain. Secondary objectives were to 1) investigate the individual effect of the significant environmental and patient characteristics of responders and 2) assess the nature and strength of the correlation of initial dose and change in pain score from arrival to pre-administration...
May 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28496479/a-comparison-of-hepatocyte-cytotoxic-mechanisms-for-docetaxel-and-plga-docetaxel-nanoparticls
#6
Bahram Daraei, Marjan Aghvami, Jalal Pourahmad, Rassoul Dinarvand
Docetaxel (DTX) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. Though, its routine clinical administration, formulated in tween 80, causes serious side effects. Polylactide-co-glycolide (PLGA), biodegradable polyester synthesized and approved for human use, is employed to overcome these problems. In this investigation, we compare the cytotoxic mechanisms of DTX and PLGA-DTX in isolated rat hepatocytes. Cytotoxicity of DTX and PLGA-DTX were associated with reactive oxygen species formation, activation of caspases cascade, collapse of mitochondrial membrane potential (MMP), lysosomal membrane leakiness and ATP depletion...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494791/a-cohort-study-examining-emergency-department-visits-and-hospital-admissions-among-people-who-use-drugs-in-ottawa-canada
#7
Claire E Kendall, Lisa M Boucher, Amy E Mark, Alana Martin, Zack Marshall, Rob Boyd, Pam Oickle, Nicola Diliso, Dave Pineau, Brad Renaud, Tiffany Rose, Sean LeBlanc, Mark Tyndall, Olivia M Lee, Ahmed M Bayoumi
BACKGROUND: The health of people who use drugs (PWUD) is characterized by multimorbidity and chronicity of health conditions, necessitating an understanding of their health care utilization. The objective of this study was to evaluate emergency department (ED) visits and hospital admissions among a cohort of PWUD. METHODS: We used a retrospective observational design between 2012 and 2013. The population was a marginalized cohort of PWUD (the PROUD study) for whom survey data was linked (n = 663) to provincial health administrative data housed at the Institute for Clinical Evaluative Sciences...
May 12, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28493045/impact-of-treatment-regimen-on-acute-care-use-during-and-after-adjuvant-chemotherapy-for-early-stage-breast-cancer
#8
REVIEW
Kathryn J Ruddy, Holly K Van Houten, Lindsey R Sangaralingham, Rachel A Freedman, Carrie A Thompson, Shahrukh K Hashmi, Ahmedin Jemal, Tufia C Haddad, Sarah Mougalian, Jeph Herrin, Cary Gross, Nilay Shah
PURPOSE: The Oncology Care Model was developed, in part, to reduce acute care use during the 6 months after chemotherapy initiation. However, little is known about the impact of chemotherapy regimen on acute care needs, or about later acute care. We sought to assess acute care use over 2 years in patients receiving four contemporary adjuvant chemotherapy regimens for breast cancer. METHODS: Administrative claims data from a large U.S. commercial insurance database (OptumLabs Data Warehouse) were used to retrospectively identify women with early-stage breast cancer who received adjuvant doxorubicin-cyclophosphamide (AC), AC followed or preceded by docetaxel or paclitaxel (AC-T), AC concurrent with docetaxel or paclitaxel (TAC), or docetaxel-cyclophosphamide (TC) between 2008 and 2014...
May 10, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28491339/the-clinical-epidemiology-and-30-day-outcomes-of-emergency-department-patients-with-acute-kidney-injury
#9
Frank Xavier Scheuermeyer, Eric Grafstein, Brian Rowe, Jay Cheyne, Brian Grunau, Aaron Bradford, Adeera Levin
BACKGROUND: Acute kidney injury (AKI) is associated with increased mortality and dialysis in hospitalized patients but has been little explored in the emergency department (ED) setting. OBJECTIVE: The objective of this study was to describe the risk factors, prevalence, management, and outcomes in the ED population, and to identify the proportion of AKI patients who were discharged home with no renal-specific follow-up. DESIGN: This is a retrospective cohort study using administrative and laboratory databases...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28485885/hospital-occupancy-and-discharge-strategies-a-simulation-based-study
#10
S Qin, C Thompson, T Bogomolov, D Ward, P Hakendorf
BACKGROUND: Increasing demand for hospital services has resulted in more arrivals to emergency department (ED), increased admissions, and, quite often, access block and ED congestion, along with patients' dissatisfaction. Cost constraints limit an increase in the number of hospital beds, so alternative solutions need to be explored. AIMS: The aims of this study were to propose and test different discharge strategies which, potentially, could reduce occupancy rates in the hospital, thereby improving patient flow and minimising frequency and duration of congestion episodes...
May 9, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28483465/use-of-medical-expulsive-therapy-in-children-an-assessment-of-nationwide-practice-patterns-and-outcomes
#11
Jonathan S Ellison, Paul A Merguerian, Benjamin C Fu, Sarah K Holt, Thomas S Lendvay, John L Gore, Margarett Shnorhavorian
INTRODUCTION: Early data support the use of medical expulsive therapy (MET) in children. However, little is known regarding use or outcomes associated with MET outside of pediatric-specific practices. Using a national administrative dataset, we sought to characterize utilization patterns of MET as well as assess outcomes associated with MET exposure. STUDY DESIGN: We interrogated the MarketScan Commercial Claims and Encounters database to identify children under the age of 18 presenting to the emergency department (ED) with any diagnosis of upper urinary tract calculi (UUTC, including renal and ureteral calculi)...
April 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28465683/chronic-administration-of-tadalafil-improves-the-symptoms-of-patients-with-amicrobic-magi-an-open-study
#12
Sandro La Vignera, Rosita A Condorelli, Laura M Mongioi, Aldo E Calogero
Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28463865/antiemetic-use-in-the-emergency-department
#13
Kyle A Weant, Abby M Bailey, Regan A Baum, Stephanie B Justice, Chara D Calhoun
Nausea and vomiting are 2 of the most common complaints of patients presenting to the emergency department (ED). In addition, antiemetics are the most commonly prescribed medications in the ED behind analgesics. Treating these conditions can be complex, especially as one considers that nausea and/or vomiting could be the primary presenting illness or simply a symptom of a more complex etiology. Although there is a wide variety of pharmacotherapeutic options in the armamentarium to treat these conditions, very few consensus recommendations exist to help guide the use of antiemetic agents in the ED, leading to wide variability in medication use...
April 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/28460864/ropivacaine-intramuscular-paracervical-injections-for-pediatric-headache-a-randomized-placebo-controlled-trial
#14
Susan K Yaeger, Michelle C Perry, Kerry Caperell, Keith A Coffman, Robert W Hickey
STUDY OBJECTIVE: We seek to determine whether ropivacaine cervical paraspinal injections compared with normal saline solution injections provide headache relief to pediatric patients that is sufficient for emergency department (ED) discharge. METHODS: We enrolled children aged 7 to 17 years in a double-blinded, randomized, controlled trial of patients presenting to a pediatric ED with headache. Subjects were randomized into 1 of 3 groups: bilateral cervical paraspinal injections of either (1) 0...
April 28, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28460808/emergency-department-septic-shock-patient-mortality-with-refractory-hypotension-vs-hyperlactatemia-a-retrospective-cohort-study
#15
Michael D April, Chase Donaldson, Lloyd I Tannenbaum, Tyler Moore, Jose Aguirre, Alexander Pingree, James H Lantry
BACKGROUND: Our objective was to compare in-hospital mortality among emergency department (ED) patients meeting trial-based criteria for septic shock based upon whether presenting with refractory hypotension (systolic blood pressure<90mmHg after 1L intravenous fluid bolus) versus hyperlactatemia (initial lactate≥4mmol/L). METHODS: We conducted a retrospective cohort analysis by chart review of ED patients admitted to an intensive care unit with suspected infection during 1 August 2012-28 February 2015...
April 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28457526/delayed-diagnoses-in-children-with-constipation-multicenter-retrospective-cohort-study
#16
Stephen B Freedman, Jonathan Rodean, Matthew Hall, Elizabeth R Alpern, Paul L Aronson, Harold K Simon, Samir S Shah, Jennifer R Marin, Eyal Cohen, Rustin B Morse, Yiannis Katsogridakis, Jay G Berry, Mark I Neuman
OBJECTIVE: The use of abdominal radiographs contributes to increased healthcare costs, radiation exposure, and potentially to misdiagnoses. We evaluated the association between abdominal radiograph performance and emergency department (ED) revisits with important alternate diagnosis among children with constipation. STUDY DESIGN: Retrospective cohort study of children aged <18 years diagnosed with constipation at one of 23 EDs from 2004 to 2015. The primary exposure was abdominal radiograph performance...
April 28, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28455163/sex-differences-in-outcomes-after-discharge-from-the-emergency-department-for-atrial-fibrillation-flutter
#17
Rhonda J Rosychuk, Brian R Holroyd, Xuechen Zhang, Brian H Rowe, Michelle M Graham
BACKGROUND: Atrial fibrillation and flutter (AFF) are the most common arrhythmias presenting to emergency departments (EDs). We examined sex differences in outcomes for patients with AFF discharged from the ED in Alberta, Canada. METHODS: ED presentations for AFF during 1999-2011 that ended in discharge were extracted from administrative databases for all Alberta residents (age ≥ 35 years). Multivariable models determined the effect of sex on the time to ED return for AFF, the first follow-up visit with a physician, the first follow-up visit with a specialist (cardiologist or internal medicine physician), and death...
April 17, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28450837/the-higher-ed-organizational-scholar-tension-how-scholarship-compatibility-and-the-alignment-of-organizational-and-faculty-skills-values-and-support-affects-scholar-s-performance-and-well-being
#18
Milagros Pereyra-Rojas, Enrique Mu, James Gaskin, Tony Lingham
Scholars and institutions alike are concerned with academic productivity. Scholars not only further knowledge in their professional fields, they also bring visibility and prestige to themselves and their institutions, which in turn attracts research grants and more qualified faculty and graduate students. Many studies have been done on scholar productivity, and many of them focus on individual factors such as gender, marital status, and individual psychological characteristics. Also, a few studies are concerned about scholars' well-being...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28444156/the-immunogenicity-of-fractional-intradermal-doses-of-the-inactivated-poliovirus-vaccine-is-associated-with-the-size-of-the-intradermal-fluid-bleb
#19
Jack Bibby, Yauba Saidu, Ama Umesi, Ngozi Moneke-Anyanwoke, Adedapo O Bashorun, Mariama Badjie Hydara, Ikechukwu Adigweme, Jane U Adetifa, Michael Okoye, Elishia Roberts, Ralf Clemens, Ananda S Bandyopadhyay, Abdul K Muhammad, Sarah Mulwa, Michael Royals, Courtney Jarrahian, Jeffries David, Beate Kampmann, Ed Clarke
The immunogenicity of fractional (1/5th, 0.1mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8 to 10mm bleb with each injection.
April 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28442107/in%C3%A2-vitro-and-in%C3%A2-vivo-investigation-of-natural-compounds-from-seed-extract-of-mucuna-pruriens-lacking-l-dopa-for-the-treatment-of-erectile-dysfunction
#20
Natthachai Duangnin, Thanyaluck Phitak, Peraphan Pothacharoen, Prachya Kongtawelert
OBJECTIVE: To investigate the biological effects of the Mucuna pruriens (M. pruriens) seed extracts that lacked l-DOPA, which was formerly reported as the active ingredient, on erectile dysfunction (ED) both in vitro and in vivo. METHODS: Seed of M. pruriens plant that cultivated in Mae Taeng District, Chiang Mai Province, Thailand, was collected. Component of its seeds were extracted and isolated into 2 fractions using methanol, polar and nonpolar. Each fraction was investigated for phytochemicals using gas chromatography and mass spectroscopy and was screened for biological activity in vitro using three different cell lines...
March 2017: Asian Pacific Journal of Tropical Medicine
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