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surgical site infection prevention

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https://www.readbyqxmd.com/read/29034380/the-immobilization-of-antibiotic-loaded-polymeric-coatings-on-osteoarticular-ti-implants-for-the-prevention-of-bone-infections
#1
Dan Li, Pengfei Lv, Linfeng Fan, Yaoyi Huang, Fei Yang, Xifan Mei, Decheng Wu
Implant-associated infections in orthopaedic surgeries are very critical as they may hinder bone healing, cause implant failure and even progress to osteomyelitis. Drug-eluting implants for local delivery of antibiotics at surgical sites are thought to be promising in preventing infections. Herein, the antibiotic vancomycin was encapsulated in a poly(ethylene glycol) (PEG)-based hydrogel film that was covalently bound to Ti implants and subsequently covered by a PEG-poly(lactic-co-caprolactone) (PEG-PLC) membrane...
October 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29032019/-experience-with-infections-in-the-use-of-extracorporeal-membrane-oxygenation
#2
Rosa María Calderón Checa, Pablo Rojo Conejo, Aranzazu Flavia González-Posada Flores, Ana María Llorente de la Fuente, Alba Palacios Cuesta, Juan Miguel Aguilar, Sylvia Belda Hofheinz
OBJECTIVE: To identify risk factors associated with infectious complications acquired by paediatric patients during extracorporeal life support (ECLS). PATIENTS AND METHODS: Patients under ECLS from January 2011 to December 2014 have been retrospectively reviewed and data on demographics, care and infectious complications were collected. RESULTS: There were 50 ECLS assistances in the study period, of which 20 patients had 23 infectious complications: 16 were bloodstream infections, with coagulase negative staphylococci being the predominant isolate (there were 2 cases of candidaemia)...
October 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29031864/bloodstream-infections-following-different-types-of-surgery-in-a-finnish-tertiary-care-hospital-2009-2014
#3
Kirsi Skogberg, Keiju S K Kontula, Asko Järvinen, Outi Lyytikäinen
We evaluated the risk and outcome of bloodstream infections (BSIs) following surgery. BSIs were identified in Helsinki University Hospital during 2009-2014 as part of the national surveillance. Of 711 BSIs identified, 51% were secondary and 49% primary. The rate was highest after cardiovascular surgery (8.7/1000 procedures) and lowest after gynaecologic (1.0/1000). Surgical site infection was the most common source of secondary BSIs (34%) and 45% of primary BSIs were central line-associated. The 28-day case fatality ranged from 0% in gynaecology/obstetrics to 21% in cardiovascular surgery...
October 12, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29030929/infection-prevention-in-pediatric-anesthesia-practice
#4
REVIEW
Lizabeth D Martin, Michael Kallile, Siri Kanmanthreddy, Danielle M Zerr
Healthcare-associated infections are an important source of morbidity and mortality in pediatric patients. Anesthesiologists have a unique role in infection prevention. Hand hygiene and anesthesia workspace decontamination decrease infection rates in surgical patients. Standard protocols exist for insertion and handling of central lines, arterial lines, and regional procedures, which should be strictly adhered to in order to prevent infectious complications. Temperature control and timely administration of antibiotics contribute to the prevention of surgical site infections...
November 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29030268/topical-vancomycin-to-reduce-surgical-site-infections-in-neurosurgery-study-protocol-for-a-multi-center-randomized-controlled-trial
#5
Alexander J Jonokuchi, Jared Knopman, Ryan E Radwanski, Moises A Martinez, Blake Eaton Samuel Taylor, Michael Rothbaum, Sean Sullivan, Trae R Robison, Brandon R Christophe, Dimitri Sigounas, Brett Youngerman, Emilia Bagiella, Peter D Angevine, Franklin D Lowy, E Sander Connolly
Surgical-site infections (SSIs) account for 20% of all healthcare-associated infections, are the most common nosocomial infection among surgical patients, and are a focus of quality improvement initiatives. Despite implementation of many quality care measures (e.g. prophylactic antibiotics), SSIs remain a significant cause of morbidity, mortality, and economic burden, particularly in the field of neurosurgery. Topical vancomycin is increasingly utilized in instrumented spinal and cardiothoracic procedures, where it has been shown to reduce the risk of SSIs...
October 10, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29020828/timing-of-antibiotic-prophylaxis-in-cesarean-section-retrospective-difference-in-differences-estimation-of-the-effect-on-surgical-site-infection
#6
Assaf Ben Shoham, Maskit Bar-Meir, Alexander Ioscovich, Arnon Samueloff, Yonit Wiener-Well
BACKGROUND: Cesarean Section (CS) is one of the most common surgical procedures performed worldwide. Surgical-site-infection (SSI) occurs in approximately 5-10% of CS. The benefit of prophylactic antibiotics for prevention of SSI has been demonstrated in the literature. The optimal timing of antibiotic prophylaxis (prior to surgical incision versus after cord clamping) was investigated in recent studies. In January 2014 the Israeli Ministry of Health introduced a national quality measure which monitors the administration of prophylactic antibiotics in CS...
October 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29020101/productivity-cost-due-to-postpartum-ill-health-a-cross-sectional-study-in-sri-lanka
#7
Nuwan Darshana Wickramasinghe, Jennifer Horton, Ishani Darshika, Kaushila Dinithi Galgamuwa, Wasantha Pradeep Ranasinghe, Thilini Chanchala Agampodi, Suneth Buddhika Agampodi
OBJECTIVE: Even though postpartum morbidity continues to cause high disease burden in maternal morbidity and mortality across the globe, the literature pertaining to resultant productivity loss is scarce. Hence, the present study aimed at determining the productivity loss and associated cost of episodes of postpartum ill health. METHODS: A cross sectional study was conducted in two Medical Officer of Heath areas in the Anuradhapura district, Sri Lanka in 2011, among 407 women residing in Anuradhapura district with an infant aged between 8 to 24 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/29016508/prophylactic-negative-pressure-wound-therapy-for-obese-women-after-cesarean-delivery-a-systematic-review-and-meta-analysis
#8
Marcela C Smid, Sarah K Dotters-Katz, Matthew Grace, Sarah T Wright, Margaret S Villers, Abbey Hardy-Fairbanks, David M Stamilio
OBJECTIVE: To summarize available studies on wound complication outcomes after prophylactic negative pressure wound therapy for obese women (body mass index 30 or greater). DATA SOURCES: We conducted a systematic review and meta-analysis using electronic database search (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Google scholar, and Web of Science), Cochrane, and trial registries including ClinicalTrials.gov. METHODS OF STUDY SELECTION: We conducted an electronic search of research articles from 1966 to January 2017 for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies of negative pressure wound therapy compared with standard dressing after cesarean delivery among obese women...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28993891/value-of-antibiotic-prophylaxis-in-routine-knee-arthroscopy-a%C3%A2-retrospective-study
#9
Yongjian Qi, Xu Yang, Zhengqi Pan, Hua Wang, Liaobin Chen
OBJECTIVE: Prophylactic antibiotic use prior to routine knee arthroscopy remains controversial. It is important to know whether antibiotics help decrease the surgical site infection (SSI) rate. Our aims were to assess the efficacy of antibiotic prophylaxis in preventing SSI and to identify risk factors for SSI following routine knee arthroscopy without an implant. METHODS: A retrospective study was conducted using the electronic medical records at the authors' hospital to identify patients that underwent routine knee arthroscopy without an implant between October 2010 and October 2016...
October 9, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28991759/the-importance-of-perioperative-prophylaxis-with-cefuroxime-or-ceftriaxone-in-the-surgical-site-infections-prevention-after-cranial-and-spinal-neurosurgical-procedures
#10
Aleksandra Dimovska-Gavrilovska, Aleksandar Chaparoski, Andreja Gavrilovski, Zvonko Milenkovikj
Introduction Surgical site infections pose a significant problem in the treatment of neurosurgical procedures, regardless of the application of perioperative prophylaxis with systemic antibiotics. The infection rate in these procedures ranges from less than 1% to above 15%. Different antibiotics and administration regimes have been used in the perioperative prophylaxis so far, and there are numerous comparative studies regarding their efficiency, however, it is generally indicated that the choice thereof should be based on information and local specifics connected to the most probable bacterial causers, which would possibly contaminate the surgical site and cause infection, and moreover, the mandatory compliance with the principles of providing adequate concentration of the drug at the time of the anticipated contamination...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28989523/preventing-surgical-site-infection-the-challenge-of-getting-it-right-first-time
#11
EDITORIAL
Jennie Wilson
No abstract text is available yet for this article.
July 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28988937/temporal-trends-and-epidemiology-of-staphylococcus-aureus-surgical-site-infection-in-the-swiss-surveillance-network-a-cohort-study
#12
Mohamed Abbas, Emin Aghayev, Nicolas Troillet, Marie-Christine Eisenring, Stefan P Kuster, Andreas F Widmer, Stephan Harbarth
BACKGROUND: Staphylococcus aureus is the leading pathogen in surgical site infections (SSIs). AIM: To explore trends and risk factors associated with S. aureus SSI. METHODS: We identified risk factors for monomicrobial S. aureus SSI from the Swiss multi-centre SSI surveillance system using multivariate logistic regression. Both in-hospital and post-discharge SSIs were identified using standardized definitions. FINDINGS: Over a 6 year period, we collected data on 229,765 surgical patients, of whom 499 (0...
October 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28987394/staphylococcus-aureus-prevention-strategies-in-cardiac-surgery-a-cost-effectiveness-analysis
#13
Jonathan C Hong, Manoj K Saraswat, Trevor A Ellison, J Trent Magruder, Todd Crawford, Julia M Gardner, William V Padula, Glenn J Whitman
BACKGROUND: Cardiac surgery patients colonized with Staphylococcus aureus have a greater risk of surgical site infection (SSI). The purpose of this study was to evaluate the cost-effectiveness of decolonization strategies to prevent SSIs. METHODS: We compared three decolonization strategies: universal decolonization (UD), all subjects treated; targeted decolonization (TD), only S aureus carriers treated; and no decolonization (ND). Decolonization included mupirocin, chlorhexidine, and vancomycin...
October 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28984214/-tilting-at-wip-windmills-in-the-or-laminar-flow-might-be-harmful
#14
L M de Brauw
The World Health Organization has published a new guideline for the prevention of surgical site infection (SSI), according to which laminar airflow systems should not be used to reduce the risk of SSI in the OR. The Dutch Health Care Inspectorate has, on the other hand, published a directive demanding laminar airflow in most operation rooms in Dutch hospitals. This directive is based on an evidence-based report from the Dutch Working Group on Infection Prevention (WIP). Since these guidelines are contradictory, the evidence presented in the WHO report as well as in the WIP report is evaluated in this article...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28975304/effect-of-post-cesarean-delivery-oral-cephalexin-and-metronidazole-on-surgical-site-infection-among-obese-women-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Amy M Valent, Chris DeArmond, Judy M Houston, Srinidhi Reddy, Heather R Masters, Alison Gold, Michael Boldt, Emily DeFranco, Arthur T Evans, Carri R Warshak
Importance: The rate of obesity among US women has been increasing, and obesity is associated with increased risk of surgical site infection (SSI) following cesarean delivery. The optimal perioperative antibiotic prophylactic regimen in this high-risk population undergoing cesarean delivery is unknown. Objective: To determine rates of SSI among obese women who receive prophylactic oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery...
September 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28974203/a-randomized-controlled-double-blind-trial-comparing-the-effects-of-the-prophylactic-antibiotic-cefazolin-administered-at-caesarean-delivery-at-two-different-timings-before-skin-incision-and-after-cord-clamping-on-both-the-mother-and-newborn
#16
Chinta Annie Jyothirmayi, Ajay Halder, Bijesh Yadav, Santosh Thomas Samuel, Anil Kuruvilla, Ruby Jose
BACKGROUND: Caesarean delivery (CD) increases the risk of postpartum infection by 5 to 20 fold. Prevention of surgical site infection (SSI) is the goal of antibiotic prophylaxis. This study was carried out to assess the optimum timing for prophylactic antibiotic administration and to assess the amount of the antibiotic crossing the placental barrier. METHODS: Eligible mothers were recruited, after informed consent, once the decision for CD was made. Each mother received two injections, one prior to skin incision and one after cord clamping, (one being the study drug Cefazolin, and the other, a placebo) based on the randomization code...
October 3, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28971093/antimicrobial-peptides-in-biomedical-device-manufacturing
#17
REVIEW
Martijn Riool, Anna de Breij, Jan W Drijfhout, Peter H Nibbering, Sebastian A J Zaat
Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28970960/risk-factors-of-surgical-site-infections-in-instrumented-spine-surgery
#18
M Dobran, A Marini, D Nasi, M Gladi, V Liverotti, M Della Costanza, F Mancini, M Scerrati
BACKGROUND: The incidence of wound infections associated with instrumented spine surgery ranges from 2 to 20%. These complications may lead to poor outcomes. Knowing the risk factors associated with surgical site infections (SSI) after utilizing spinal implants is essential to avoid these complications, including hardware removal. METHODS: We reviewed retrospectively 550 patients who underwent spinal fusion surgery from 2011 to 2015; 16 developed SSI after spinal instrumentation...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28967511/does-surgical-site-infection-after-caesarean-section-in-polish-hospitals-reflect-high-quality-patient-care-or-poor-postdischarge-surveillance-results-from-a-3-year-multicenter-study
#19
Anna Różańska, Andrzej Jarynowski, Katarzyna Kopeć-Godlewska, Jadwiga Wójkowska-Mach, Agnieszka Misiewska-Kaczur, Marzena Lech, Małgorzata Rozwadowska, Marlena Karwacka, Joanna Liberda, Joanna Domańska
BACKGROUND: Caesarean sections (CSs) are associated with a high infection risk. Surgical site infection (SSI) incidence is among the markers of effectiveness of infection prevention efforts. The aim of this study was to analyze risk factors for SSI, incidence, and microbiology in patients who underwent CS. METHODS: The study was conducted during 2013-2015 using active infection surveillance in 5 Polish hospitals according to the European Centre for Disease Prevention and Control surveillance network known as HAI-Net...
September 26, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28965993/ankle-fusion-in-hemophilic-patients
#20
D Eichler, M Ehlinger, A D'Ambrosio, D Desprez, G Bierry, P Adam, F Bonnomet
INTRODUCTION: Hemophilic arthropathy is painful and disabling. We report a retrospective study of ankle fusion with intra- and peri-operative clotting factor perfusion. The objective was to assess the efficacy of maintaining perioperative clotting factor rates close to 100%, and report long-term results. The study hypothesis was that results would be good, without early hemorrhagic complications. MATERIAL AND METHOD: Between 2000 and 2013, 12 ankle fusions were performed in 9 patients, with a mean age of 39 years (range, 19-58 years)...
September 28, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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