Nicholas C Allen, Andrew J Martin, Victoria A Snaidr, Renee Eggins, Alvin H Chong, Pablo Fernandéz-Peñas, Douglas Gin, Shireen Sidhu, Vanessa L Paddon, Leith A Banney, Adrian Lim, Edward Upjohn, Helmut Schaider, Aparna D Ganhewa, Jennifer Nguyen, Catriona A McKenzie, Saurabh Prakash, Catriona McLean, Alistair Lochhead, Jan Ibbetson, Andrew Dettrick, Anthony Landgren, Katherine J Allnutt, Clare Allison, Rachael B Davenport, Blake P Mumford, Brittany Wong, Brendan Stagg, Alexander Tedman, Hannah Gribbin, Harrison A Edwards, Nicholas De Rosa, Thomas Stewart, Brent J Doolan, Yonatan Kok, Kate Simpson, Zhi M Low, Tom Kovitwanichkanont, Richard A Scolyer, Haryana M Dhillon, Janette L Vardy, Steven J Chadban, David G Bowen, Andrew C Chen, Diona L Damian
BACKGROUND: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3 ) enhances the repair of ultraviolet (UV) radiation-induced DNA damage, reduces the cutaneous immunosuppressive effects of UV radiation, and reduces the incidence of keratinocyte cancers (including squamous-cell and basal-cell carcinomas) and actinic keratoses among high-risk immunocompetent patients. Whether oral nicotinamide is useful for skin-cancer chemoprevention in organ-transplant recipients is unclear...
March 2, 2023: New England Journal of Medicine