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Tong Tang

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https://www.readbyqxmd.com/read/28550390/clinical-patterns-and-characteristics-of-ankylosing-spondylitis-in-china
#1
Qiaoxia Qian, Xia Xu, Hongjun He, Hengdong Ji, Hui Zhang, Yue Ding, Sheng-Ming Dai, Yaohong Zou, Qi Zhu, Chengde Yang, Shuang Ye, Lindi Jiang, Jian-Ping Tang, Qiang Tong, Dongyi He, Dongbao Zhao, Yuan Li, Yanyun Ma, Jingru Zhou, Ziyu Yuan, Juan Zhang, Li Jin, Xiaodong Zhou, John D Reveille, Hejian Zou, Jiucun Wang
The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset. The multicenter cross-sectional survey was conducted and 1251 patients were enrolled across China, representing a broad spectrum of Chinese AS patients. The mean age at onset and diagnosis were 29.2 (11.4) and 33.5 (12.6) years, respectively. The male/female ratio was 2.7:1. Acute anterior uveitis (AAU) was experienced in 10...
May 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28548944/the-adenosine-a2b-receptor-promotes-tumor-progression-of-bladder-urothelial-carcinoma-by-enhancing-mapk-signaling-pathway
#2
Yihong Zhou, Xi Chu, Fei Deng, Liang Tong, Guoxiong Tong, Ye Yi, Jianye Liu, Jin Tang, Yuxin Tang, Yang Xia, Yingbo Dai
The adenosine A2b receptor (A2bR) was considered to play an oncogenic role in many human malignancies. However, the expression and molecular function of A2bR in bladder urothelial carcinoma (BUC) have not been well elucidated. Herein, we found that the expression of A2bR was higher than other adenosine receptors in BUC tissues and cells, and it was upregulated in BUC tissues compared with matched normal bladder tissues. Furthermore, high expression of A2bR was associated with poor prognosis of patients with BUC...
May 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28541352/copper-i-mediated-carboamination-of-vinyl-azides-by-aryldiazonium-salts-synthesis-of-n-2-substituted-1-2-3-triazoles
#3
Zhenhua Liu, Huimin Ji, Wen Gao, Guangyu Zhu, Lili Tong, Fengcai Lei, Bo Tang
A copper(i)-mediated carboamination cascade reaction between vinyl azides and aryldiazonium salts is described. Functionally diverse N(2)-substituted 1,2,3-triazoles were obtained in moderate to good yields through novel difunctionalization of vinyl azides by aryldiazonium salt sources. This method has a wide scope, good functional-group tolerance and insensitivity to an ambient atmosphere.
May 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28535566/the-analgesic-effects-of-celecoxib-on-the-formalin-induced-short-and-long-term-inflammatory-pain
#4
Ya-Qun Zhao, Hai-Yan Wang, Jun-Bin Yin, Yan Sun, Yong Wang, Jin-Chuan Liang, Xiao-Ju Guo, Ke Tang, Yu-Tong Wang
The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects. In previous studies, it has been shown that celecoxib can inhibit formalin-induced spontaneous pain and secondary hyperalgesia. Injecting formalin into a rodent's hind paw not only induces acute pain behaviors, but also produces long-lasting hyperalgesia. Whether celecoxib can also have long-lasting effects is still unknown. Our results show that pretreatment with an intraperitoneal injection of celecoxib at one hour before formalin injection induced inhibition on the spontaneous flinch and licking behaviors in the second phase but not the first phase...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535433/a-highly-selective-surface-coating-for-enhanced-membrane-rejection-of-endocrine-disrupting-compounds-mechanistic-insights-and-implications
#5
Hao Guo, Yu Deng, Zhikan Yao, Zhe Yang, Jianqiang Wang, Chuner Lin, Tong Zhang, Baoku Zhu, Chuyang Y Tang
We designed a highly selective surface coating to achieve enhanced rejection of endocrine disrupting compounds (EDCs) by nanofiltration membranes. A commercial NF90 membrane was first coated with polydopamine (PDA) followed by in situ immobilization of silver nanoparticles (AgNPs). This PDA/AgNPs coating greatly improved EDC rejection at the expense of slight water permeability loss (4-10%). This improvement in rejection can be attributed to a combination of enhanced size exclusion and suppressed hydrophobic interaction...
May 18, 2017: Water Research
https://www.readbyqxmd.com/read/28528230/effect-of-childhood-trauma-on-cognitive-functions-in-a-sample-of-chinese-patients-with-schizophrenia
#6
Xian-Bin Li, Qi-Jing Bo, Guang-Ping Zhang, Wei Zheng, Zhi-Min Wang, An-Ning Li, Qing Tian, Jin-Tong Liu, Yi-Lang Tang, Chuan-Yue Wang
In this study, we aimed to determine the influence of various types of childhood trauma (CT) on cognitive functions in Chinese patients presented with schizophrenia. One hundred sixty-two patients were assessed with the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We investigated the correlations between various types of CT, demographic characteristics, and cognitive functions. Significant negative correlations were observed in physical abuse (PA) and sexual abuse (SA) with the language score (r=-0...
May 5, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28526640/zero-profile-spacer-versus-cage-plate-construct-in-anterior-cervical-discectomy-and-fusion-for-multilevel-cervical-spondylotic-myelopathy-a-systematic-review-and-meta-analysis
#7
Min-Ji Tong, Guang-Heng Xiang, Zi-Li He, De-Heng Chen, Qian Tang, Hua-Zi Xu, Nai-Feng Tian
BACKGROUD: Anterior cervical discectomy and fusion (ACDF) with plate-screw construct has been gradually applied for multilevel cervical spondylotic myelopathy (CSM) in recent years. However, long cervical plate was associated with complications including breakage or loosening of plate and screws, trachea-esophageal injury, neurovascular injury, and postoperative dysphagia. To reduce these complications, the zero-profile spacer has been introduced. This meta-analysis was performed to compared the clinical and radiological outcomes of zero-profile spacer versus cage-plate construct for the treatment of multilevel cervical spondylotic myelopathy...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28514763/the-value-of-diffusion-kurtosis-imaging-in-assessing-pathological-complete-response-to-neoadjuvant-chemoradiation-therapy-in-rectal-cancer-a-comparison-with-conventional-diffusion-weighted-imaging
#8
Feixiang Hu, Wei Tang, Yiqun Sun, Dang Wan, Sanjun Cai, Zhen Zhang, Robert Grimm, Xu Yan, Caixia Fu, Tong Tong, Weijun Peng
OBJECTIVES: The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28499936/ucbt-without-antithymocyte-globulin-results-in-similar-survival-but-better-quality-of-life-compared-with-upbsct-for-the-treatment-of-acute-leukemia-a-retrospective-study-in-china
#9
J Tong, L Xuan, Y L Sun, D P Huang, H L Liu, C C Zheng, X Y Zhu, B L Tang, K D Song, X H Zhang, L Zhang, W Yao, D J Lin, Q F Liu, Z M Sun
While previous studies have demonstrated improved outcomes in umbilical cord blood transplantation (UCBT) by omitting antithymocyte globulin (ATG) in the conditioning regimen, this approach has not been comparatively studied in unrelated peripheral blood stem cell transplantation (UPBSCT). To compare the risks and benefits between UCBT without ATG and UPBSCT in patients with acute leukemia (AL). This was a multicenter retrospective study of 79 patients who underwent UCBT (myeloablative conditioning without ATG) and 96 patients who underwent UPBSCT (myeloablative conditioning with ATG)...
May 9, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28497046/corrigendum-to-quantitative-evaluation-and-selection-of-reference-genes-for-quantitative-rt-pcr-in-mouse-acute-pancreatitis
#10
Zhaoping Yan, Jinhang Gao, Xiuhe Lv, Wenjuan Yang, Shilei Wen, Huan Tong, Chengwei Tang
[This corrects the article DOI: 10.1155/2016/8367063.].
2017: BioMed Research International
https://www.readbyqxmd.com/read/28494195/functionally-inactivated-dominant-viral-antigens-of-human-cytomegalovirus-delivered-in-replication-incompetent-adenovirus-type-6-vectors-as-vaccine-candidates
#11
Aimin Tang, Daniel C Freed, Fengsheng Li, Steve Meschino, Michael Prokop, Andrew Bett, Danilo Casimiro, Dai Wang, Tong-Ming Fu
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation. Here we report efforts to construct replication incompetent adenovirus 6 vectors expressing these viral antigens as vaccine candidates. To reduce the potential liabilities of these viral proteins as vaccine antigens, we introduced mutations to inactivate their reported functions including their nuclear localization signals...
May 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28493836/carbohydrate-antigen-125-and-carcinoembryonic-antigen-in-the-differentiation-of-tuberculous-peritonitis-and-peritonitis-carcinomatosa
#12
Huan Tong, Yang Tai, Cheng Ye, Hao Wu, Lin-Hao Zhang, Jin-Hang Gao, Zhao-Ping Yan, Zhi-Yin Huang, Cheng-Wei Tang
Tumor markers could increase in both tuberculous peritonitis and peritonitis carcinomatosa, confusing the differentiation of these diseases. This study aimed to better understand the extent of elevation and diagnostic efficacies of carbohydrate antigen 125 (CA 125), carcinoembryonic antigen (CEA) and combinative use of them in tuberculous peritonitis and peritonitis carcinomatosa. Of 2998 patients reviewed, 101, 120 and 71 patients were assigned to TBP group (tuberculous peritonitis), non-OCA group (non-ovarian carcinoma-related peritonitis carcinomatosa) and OCA group (ovarian carcinoma-related peritonitis carcinomatosa), respectively...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493834/establishing-a-patient-derived-xenograft-model-of-human-myxoid-and-round-cell-liposarcoma
#13
Yiming Qi, Yu Hu, Hua Yang, Rongyuan Zhuang, Yingyong Hou, Hanxing Tong, Yi Feng, Yuan Huang, Quan Jiang, Qunsheng Ji, Qingyang Gu, Zhixiang Zhang, Xuzhen Tang, Weiqi Lu, Yuhong Zhou
Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. A tumor sample from a patient with MRCL was implanted subcutaneously in an immunodeficient mouse shortly after resection to establish a patient-derived tumor xenograft model. After the tumor grew, it was resected and divided into several pieces for re-implantation and tumor passage...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28488695/blockade-of-ido-kynurenine-ahr-metabolic-circuitry-abrogates-ifn-%C3%AE-induced-immunologic-dormancy-of-tumor-repopulating-cells
#14
Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F Xiao-Feng Qin, Bo Huang
Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D fibrin gel model, we show that IFN-γ induces tumour-repopulating cells (TRCs) to enter dormancy through an indolamine 2,3-dioxygenase 1 (IDO1)-kynurenine (Kyn)-aryl hydrocarbon receptor (AhR)-p27 dependent pathway. Mechanistically, IFN-γ signalling triggers differentiated tumour cell apoptosis via STAT1; however, when IDO1 and AhR are highly expressed as in TRCs, IFN-γ results in IDO1/AhR-dependent p27 induction that prevents STAT1 signalling, thus suppressing the process of cell death and activating the dormancy program...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28482291/sustained-delivery-of-insulin-loaded-block-copolymers-potential-implications-on-renal-ischemia-reperfusion-injury-in-diabetes-mellitus
#15
Fei Tong, Xiangyuan Tang, Lei Luo, Xin Li, Wenquan Xia, Chao Lu, Daojun Liu
The purpose of this research was to evaluate the protective effects of insulin-loaded poly(ethylene glycol)-b-poly((2-aminoethyl-l-glutamate)-g-poly(l-lysine)) (PEG-b-P(ELG-g-PLL)) on renal ischemia/reperfusion (I/R) injury in rats with diabetes mellitus. Rats were preconditioned with free insulin or insulin/PEG-b-P(ELG-g-PLL) polyplexes, then subjected to renal I/R. The blood and kidneys were then harvested, Glucose uptake rate, glucose transporter 4 (GULT4) mRNA level, cell membrane GULT4 content and GULT4 expression were measured, the level of serum creatinine and blood urea nitrogen were determined, the activity of superoxide dismutase and inducible nitric oxide synthase, the content of malondialdehyde and nitric oxide, reactive oxygen species (ROS) production and nuclear factor κB (NF-κB) mRNA level, Bcl-2 assaciated x protein (Bax) mRNA and B cell lymphoma/lewkmia-2 (Bcl-2) mRNA level, and the expression of protein 47kDa phagocyte oxidase (p47phox) in renal tissues were measured...
May 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28482164/brucella-melitensis-m5-90%C3%A2-bp26-as-a-potential-live-vaccine-that-allows-for-the-distinction-between-natural-infection-and-immunization
#16
Tiansen Li, Zhixia Tong, Meiling Huang, Liyan Tang, Hui Zhang, Chuangfu Chen
Brucella is Gram-negative intracellular bacterial pathogen that infects humans and animals and contributes to great economic losses in developing countries. Presently, live attenuated Brucella vaccines (B. melitensis strain M5-90) are the most effective means of brucellosis control and prevention in animals. However, these vaccines have several drawbacks, such as an inability to distinguish between a natural infection and immunization and an association with abortions in pregnant animals. Therefore, this study constructed a Brucella M5-90△bp26 mutant and evaluated its virulence...
May 8, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28479909/effect-of-individualized-diabetes-education-for-type-2-diabetes-mellitus-a-single-center-randomized-clinical-trial
#17
Min-Hua Fan, Bing-Tong Huang, Ying-Chun Tang, Xiu-Hua Han, Wei-Wei Dong, Le-Xin Wang
BACKGROUND: To evaluate the effect of individualized education for patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 280 patients (158 males, mean age 63 ± 10 years) with T2DM were randomly divided into study and control group. Eysenck Personality questionnaire was used to assess the personality of the patients in the study group, which was provided us one-on-one counseling and individualized management plan. Group education was provided to the control group...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28474130/blood-vessel-segmentation-in-color-fundus-images-based-on-regional-and-hessian-features
#18
Syed Ayaz Ali Shah, Tong Boon Tang, Ibrahima Faye, Augustinus Laude
PURPOSE: To propose a new algorithm of blood vessel segmentation based on regional and Hessian features for image analysis in retinal abnormality diagnosis. METHODS: Firstly, color fundus images from the publicly available database DRIVE were converted from RGB to grayscale. To enhance the contrast of the dark objects (blood vessels) against the background, the dot product of the grayscale image with itself was generated. To rectify the variation in contrast, we used a 5 × 5 window filter on each pixel...
May 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28463776/tddft-study-on-recognition-mechanism-for-the-oxygen-sensing-of-the-cyclometalated-platinum-ii-complex
#19
Huan Tong, Zhengyan Zhao, Guanglan Li, Liguo Gao, Ningjiu Zhao, Peng Li, Yan Jia, Chenyang Zhou, Mingzhen Zhang, Yong Wang, Ce Hao, Xiaoying Tang
The influence of oxygen molecule on the luminescent properties of a cyclometalated Pt(II) complex Lxp1, was investigated using density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods. Analysis of frontier molecular orbitals and electronic configuration indicated that the highest-occupied molecular orbital of the Lxp1 has a significant mixture of metal Pt (d) as well as 2-phenylpyridine and acetyl acetone(π). The lowest-unoccupied orbital of the Lxp1 primarily locates on π* of 2-phenylpyridineligands...
April 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28461778/expression-profile-of-mitochondrial-voltage-dependent-anion-channel-1-vdac1-influenced-genes-is-associated-with-pulmonary-hypertension
#20
Tong Zhou, Haiyang Tang, Ying Han, Dustin Fraidenburg, Young-Won Kim, Donghee Lee, Jeongyoon Choi, Hyoweon Bang, Jae-Hong Ko
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology...
May 2017: Korean Journal of Physiology & Pharmacology
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