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Tong Tang

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https://www.readbyqxmd.com/read/29344217/aleukemic-extramedullary-t-lymphoid-myeloid-bilineage-hematopoietic-and-lymphoid-malignancy-with-progression-to-bilineage-leukemia-at-relapse-a-case-report
#1
Mengyao Wu, Xiaoqiu Li, Feng Tang, Ping Zhu, Tianling Ding, Yan Yuan, Tong Chen
Bilineage T lymphoid and myeloid (T/My) neoplasms are rare entities among the hematopoietic and lymphoid malignancies. The majority of patients present with leukemic symptoms in which blasts are observed in the peripheral blood (PB) or bone marrow (BM) at a percentage of >20% of nucleated cells. Only a minimal number of cases of T/My bilineage hematopoietic and lymphoid malignancy have been reported with extramedullary infiltration as the initial symptom. The origin of the neoplastic cells in T/My bilineage malignancy has been documented as the hematopoietic stem cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29335200/discovery-and-optimization-of-phthalazinone-derivatives-as-a-new-class-of-potent-dengue-virus-inhibitors
#2
Dong Lu, Jianan Liu, Yunzhe Zhang, Feifei Liu, Limin Zeng, Runze Peng, Li Yang, Huazhou Ying, Wei Tang, Wuhong Chen, Jianping Zuo, Xiankun Tong, Tao Liu, Youhong Hu
Using a dengue replicon cell line-based screening, we identified 3-(dimethylamino)propyl(3-((4-(4-fluorophenyl)-1-oxophthalazin-2(1H)-yl)methyl)phenyl)carbamate (10a) as a potent DENV-2 inhibitor, with an IC50 value of 0.64 μM. A series of novel phthalazinone derivatives based on hit 10a were synthesized and evaluated for their in vitro anti-DENV activity and cytotoxicity. The subsequent SAR study and optimization led to the discovery of the most promising compound 14l, which displayed potent anti-DENV-2 activity, with low IC50 value against DENV-2 RNA replication of 0...
January 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29328331/directional-torsion-and-temperature-discrimination-based-on-a-multicore-fiber-with-a-helical-structure
#3
Hailiang Zhang, Zhifang Wu, Perry Ping Shum, Xuguang Shao, Ruoxu Wang, Xuan Quyen Dinh, Songnian Fu, Weijun Tong, Ming Tang
We propose and experimentally demonstrate a directional torsion sensor based on a Mach-Zehnder interferometer formed in a multicore fiber (MCF) with a ~570-μm-long helical structure (HS). The HS was fabricated into the MCF by simply pre-twisting and then heating with a CO2 laser splicing system. This device shows the capability of directional torsion measurement from -17.094 rad/m to 15.669 rad/m with the sensitivity of ~0.118 nm/(rad/m). Moreover, since the multiple interferences respond differently to torsion and temperature simultaneously, the temperature cross-sensitivity of the proposed sensor can be eliminated effectively...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29323107/serological-survey-of-neutralizing-antibodies-to-eight-major-enteroviruses-among-healthy-population
#4
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29322523/prevalence-of-pollen-induced-allergic-rhinitis-with-high-pollen-exposure-in-grasslands-of-northern-china
#5
Xue-Yan Wang, Ting-Ting Ma, Xiao-Yan Wang, Yan Zhuang, Xiang-Dong Wang, Hui-Yu Ning, Hai-Yun Shi, Rui-Li Yu, Dan Yan, Hong-Dong Huang, Yong-Fei Bai, Guang-Liang Shan, Biao Zhang, Qing-Kun Song, Yan-Fen Zhang, Tie-Jun Zhang, Da-Zhong Jia, Xi-Long Liu, Zhen-Xiang Kang, Wei-Jun Yan, Ba-Te Yang, Xiu-Zhi Bao, Shu-Hua Sun, Fang-Fang Zhang, Wen-Hui Yu, Chao-Lu Bai, Tang Wei, Tong Yang, Tao-Qiong Ma, Xue-Bin Wu, Jian-Guo Liu, Hui Du, Luo Zhang, Yong Yan, De-Yun Wang
BACKGROUND: The aim of this study was to investigate the prevalence of epidemiologic and physician-diagnosed pollen-induced AR (PiAR) in the grasslands of northern China, and to study the impact of the intensity and time of pollen exposure on PiAR prevalence. METHODS: A multistage, clustered and proportionately stratified random sampling with a field-interviewer administrated survey study was performed together with skin prick tests (SPT) and measurements of the daily pollen count...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29321316/two-residues-in-nsp9-contribute-to-the-enhanced-replication-and-pathogenicity-of-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus
#6
Kuan Zhao, Jia-Cong Gao, Jun-Yao Xiong, Jin-Chao Guo, Yong-Bo Yang, Cheng-Gang Jiang, Yan-Dong Tang, Zhi-Jun Tian, Xue-Hui Cai, Guang-Zhi Tong, Tong-Qing An
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) possesses greater replicative capacity and pathogenicity than classical PRRSV. However, the factors that lead to enhanced replication and pathogenicity remain unclear. In our study, an alignment of all available full-length sequences of North-American type PRRSVs (n = 204) revealed two consistent amino acid mutations that differed between HP-PRRSV and classical PRRSV and were located at positions 519 and 544 in non-structural protein 9...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29306778/influence-on-proliferation-and-adhesion-of-human-gingival-fibroblasts-from-different-titanium-surface-decontamination-treatments-an-in-vitro-study
#7
Cao Jie, Tong Wang, Pu Yinfei, Tang Zhihui, Meng Huanxin
OBJECTIVES: To investigate the effects of different decontamination treatments on microstructure of titanium (Ti) surface as well as proliferation and adhesion of human gingival fibroblasts (HGFs). MATERIAL AND METHODS: Ti discs with machined (M) and sand blasted, acid etched (SAE) surfaces were treated with five different decontamination treatments: (1) stainless steel curette (SSC), ultrasonic system with (2) straight carbon fiber tip (UCF) or (3) metal tip (UM), (4) rotating Ti brush (RTB), and (5) Er:YAG laser (30 mJ/pulse at 30 Hz)...
December 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29301415/ph-sensitive-polymeric-nanoparticles-of-mpeg-plga-pglu-with-hybrid-core-for-simultaneous-encapsulation-of-curcumin-and-doxorubicin-to-kill-the-heterogeneous-tumour-cells-in-breast-cancer
#8
Jian-Dong Yuan, De-Li ZhuGe, Meng-Qi Tong, Meng-Ting Lin, Xia-Fang Xu, Xing Tang, Ying-Zheng Zhao, He-Lin Xu
Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29285919/ultra-sensitive-flexible-proximity-sensor-based-on-organic-crystal-for-location-detection
#9
Haiting Wang, Qingxin Tang, Xiaoli Zhao, Yanhong Tong, Yichun Liu
A new type of flexible proximity sensor that uses the micro-sized organic crystal as the sensing element is demonstrated. The two-terminal organic sensor can accurately perceive the external objects, such as the human finger, fibre and even AFM tip. The proximity sensor shows an unprecedented distance resolution of 0.05 mm, which is two order of magnitude higher than that of previously reported conventional capacitor proximity sensors. A novel method has been proposed to realize the location detection of the approaching unknown object by modulating the relative distance between stimuli object and sensor...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29273561/cross-linked-enzyme-aggregates-cleas-of-halohydrin-dehalogenase-from-agrobacterium-radiobacter-ad1-preparation-characterization-and-application-as-a-biocatalyst
#10
Qian Liao, Xuan Du, Wei Jiang, Yapei Tong, Zhipeng Zhao, Ruiqin Fang, Juan Feng, Lixia Tang
Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) shows great potential to produce valuable optically pure epoxides and β-substituted alcohols. However, this enzyme has been reported to be very sensitive and less stable under oxidative conditions. Enzyme immobilization represents a powerful means to overcome this limitation and provides the enzyme characteristics of a biocatalyst. In this study, the crude extract of HheC was directly subjected to enzyme immobilization using a carrier-free cross-linked enzyme aggregates (CLEAs) method...
December 19, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29260533/-effect-of-proton-pump-inhibitors-on-severe-acute-pancreatitis-a-prospective-randomized-trial
#11
Xiao Ma, Cheng-Wei Tang, Zhi-Yin Huang, Ming-Guang Zhang, Fang Liu, Chun-Hui Wang, Rui Wang, Huan Tong, Ling Liu
OBJECTIVE: To evaluate the effect of proton pump inhibitors (PPIs) therapy on severe acute pancreatitis (SAP) patients. METHODS: Forty five patients with SAP recruited in our center from October 2015 to October 2016,were randomly assigned into two groups: convention group (C group,n=21) and convention+esomeprazole group (C+E group,n=24). C+E group received esomeprazole 40 mg/d intravenously for 1 week,whereas C group only received baseline treatment. Serum C-reactive protein (CRP),interleukin-6 (IL-6) and interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) were detected by ELISA on the first day (baseline) and the seventh day...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29248507/potential-diagnostic-power-of-blood-circular-rna-expression-in-active-pulmonary-tuberculosis
#12
Zhongqing Qian, Hui Liu, Musheng Li, Junchao Shi, Na Li, Yao Zhang, Xiaojie Zhang, Jingzhu Lv, Xueying Xie, Yunfei Bai, Qinyu Ge, Eun-A Ko, Haiyang Tang, Ting Wang, Xiaojing Wang, Zhaohua Wang, Tong Zhou, Wanjun Gu
BACKGROUND: Circular RNAs (circRNAs) are a class of novel RNAs with important biological functions, and aberrant expression of circRNAs has been implicated in human diseases. However, the feasibility of using blood circRNAs as disease biomarkers is largely unknown. METHODS: We explored the potential of using human peripheral blood mononuclear cell (PBMC) circRNAs as marker molecules to diagnose active pulmonary tuberculosis (TB). FINDINGS: First, we demonstrated that circRNAs are widely expressed in human PBMCs and that many are abundant enough to be detected...
December 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29245228/use-of-concomitant-variceal-embolization-and-prophylactic-antiplatelet-anticoagulative-in-transjugular-intrahepatic-portosystemic-shunting-a-retrospective-study-of-182-cirrhotic-portal-hypertension-patients
#13
Yingmei Tang, Sheng Zheng, Jinhui Yang, Weimin Bao, Lihong Yang, Yingchun Li, Ying Xu, Jing Yang, Yuyun Tong, Jinhang Gao, Chengwei Tang
Transjugular intrahepatic portosystemic shunting (TIPS) is an effective treatment modality for refractory variceal bleeding and ascites in patients with cirrhotic portal hypertension (CPH). Variceal rebleeding and shunt dysfunction are major post-TIPS morbidities. This study aimed to retrospectively evaluate the effectiveness and safety of use of concomitant variceal embolization and prophylactic antiplatelet/anticoagulative in patients with CPH undergoing TIPS. Between October 2006 and October 2011, 182 patients with CPH were retrospectively and consecutively hospitalized for elective TIPS with Fluency stenting...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29238529/elevational-diversity-gradients-of-tibetan-loaches-the-relative-roles-of-ecological-and-evolutionary-processes
#14
Chenguang Feng, Yongjie Wu, Fei Tian, Chao Tong, Yongtao Tang, Renyi Zhang, Guogang Li, Kai Zhao
It is widely believed that species richness patterns (SRPs) are shaped by both ecological and evolutionary processes. However, the relative roles of these processes remain unclear, especially for aquatic organisms. In this study, we integrated ecological and evolutionary measures to tease apart the relative influences of these factors on the SRP of Tibetan loaches along an extensive elevational gradient. We found that the Tibetan loaches displayed a richness pattern that peaked at midelevations. The mean annual temperature (MAT), mid-domain effect (MDE), and summed age of colonization (SAC, complex of colonization age and colonization frequency) were the main drivers, accounting for 85%, 51%, and 88% of the variations in the SRP, respectively...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238039/helicobacter-pylori-vaca-induces-autophagic-cell-death-in-gastric-epithelial-cells-via-the-endoplasmic-reticulum-stress-pathway
#15
Pan Zhu, Jun Xue, Zhu-Jun Zhang, Yin-Ping Jia, Ya-Nan Tong, Dan Han, Qian Li, Yang Xiang, Xu-Hu Mao, Bin Tang
The Helicobacter pylori vacuolating cytotoxin (VacA) can promote progressive vacuolation and gastric injury and may be associated with human gastric cancer. Increasing evidence indicates that autophagy is involved in the cell death induced by VacA, but the specific mechanisms need to be further elucidated. We show here that VacA could induce autophagy and increase cell death in human gastric cancer cell lines. Further investigations revealed that inhibition of autophagy could decrease the VacA-induced cell death in AGS cells...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29224194/establishment-and-evaluation-of-an-indirect-immunofluorescence-assay-for-the-detection-of-salmonid-alphavirus
#16
S Gao, W Shi, Y T Wang, M T Guo, K X Duan, A C Song, G H Lian, Tong Ren, Y J Li, L J Tang, L Sun, M Liu
Salmonid alphaviruses (SAV) severely infects farmed salmonids and rainbow trout. Owing to the recent increase in fish import trade, several SAV-unreported countries, such as China, may face serious threat of this infection. Thus, it is necessary to develop efficient detection methods for the prevention and diagnosis of SAV infection. In this study, we selected a conserved segment of the SAV E1 protein as a target immunogen for the preparation of monoclonal antibodies (mAbs) specific to SAV. A sensitive indirect immunofluorescence (IF) method was developed using 26E9C2 mAb that detected E1 protein and identified subtypes 1, 2 and 5 of SAV...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29221303/the-society-for-translational-medicine-clinical-practice-guidelines-for-the-postoperative-management-of-chest-tube-for-patients-undergoing-lobectomy
#17
REVIEW
Shugeng Gao, Zhongheng Zhang, Javier Aragón, Alessandro Brunelli, Stephen Cassivi, Ying Chai, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, David Tom Cooke, John B Downs, Pierre-Emmanuel Falcoz, Wentao Fang, Pier Luigi Filosso, Xiangning Fu, Seth D Force, Martínez I Garutti, Diego Gonzalez-Rivas, Dominique Gossot, Henrik Jessen Hansen, Jianxing He, Jie He, Bo Laksáfoss Holbek, Jian Hu, Yunchao Huang, Mohsen Ibrahim, Andrea Imperatori, Mahmoud Ismail, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Hyun Koo Kim, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Eric Lim, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Kevin W Lobdell, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, Nuria M Novoa, René H Petersen, Hiroyuki Oizumi, Kostas Papagiannopoulos, Cecilia Pompili, Guibin Qiao, Majed Refai, Gaetano Rocco, Erico Ruffini, Michele Salati, Agathe Seguin-Givelet, Alan Dart Loon Sihoe, Lijie Tan, Qunyou Tan, Tang Tong, Kosmas Tsakiridis, Federico Venuta, Giulia Veronesi, Nestor Villamizar, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Gavin M Wright, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy. Recommendations were produced and classified based on an internationally accepted GRADE system. The following recommendations were extracted in the present review: (I) chest tubes can be removed safely with daily pleural fluid of up to 450 mL (non-chylous and non-sanguinous), which may reduce chest tube duration and hospital length of stay (2B); (II) in rare instances, e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221302/the-society-for-translational-medicine-clinical-practice-guidelines-for-mechanical-ventilation-management-for-patients-undergoing-lobectomy
#18
REVIEW
Shugeng Gao, Zhongheng Zhang, Alessandro Brunelli, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, Stephen Cassivi, Ying Chai, John B Downs, Wentao Fang, Xiangning Fu, Martínez I Garutti, Jianxing He, Jie He, Jian Hu, Yunchao Huang, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, René H Petersen, Guibin Qiao, Gaetano Rocco, Erico Ruffini, Lijie Tan, Qunyou Tan, Tang Tong, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
Patients undergoing lobectomy are at significantly increased risk of lung injury. One-lung ventilation is the most commonly used technique to maintain ventilation and oxygenation during the operation. It is a challenge to choose an appropriate mechanical ventilation strategy to minimize the lung injury and other adverse clinical outcomes. In order to understand the available evidence, a systematic review was conducted including the following topics: (I) protective ventilation (PV); (II) mode of mechanical ventilation [e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218025/stimulating-the-right-temporoparietal-junction-with-tdcs-decreases-deception-in-moral-hypocrisy-and-unfairness
#19
Honghong Tang, Peixia Ye, Shun Wang, Ruida Zhu, Song Su, Luqiong Tong, Chao Liu
Self-centered and other-regarding concerns play important roles in decisions of deception. To investigate how these two motivations affect deception in fairness related moral hypocrisy, we modulated the brain activity in the right temporoparietal junction (rTPJ), the key region for decision making involved in self-centered and other-regarding concerns. After receiving brain stimulation with transcranial direct current stimulation (tDCS), participants finished a modified dictator game. In the game, they played as proposers to make allocations between themselves and recipients and had a chance to deceive by misreporting their totals for allocations...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29212278/efficacy-and-safety-of-pancreatic-enzyme-replacement-therapy-on-exocrine-pancreatic-insufficiency-a-meta-analysis
#20
Can Gan, Yan-Hua Chen, Ling Liu, Jin-Hang Gao, Huan Tong, Cheng-Wei Tang, Rui Liu
Background: Pancreatic enzyme replacement therapy (PERT) is widely applied to patients with exocrine pancreatic insufficiency (EPI), but its effect and safety has not been quantified. Therefore we performed a meta-analysis to determine the efficacy and tolerance of PERT on patients with EPI. Materials and Methods: PubMed, Medline, Cochrane library database, Evidence-based medicine/clinical trials published before December 2016 were searched by two independent reviewers to identify prospective randomized controlled trials (RCTs)...
November 7, 2017: Oncotarget
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