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Tong Tang

Pu Liu, Chao Zhang, Jin-Qi Ma, Li-Yuan Zhang, Bo Yang, Xin-Yu Tang, Ling Huang, Xin-Tong Zhou, Kun Lu, Jia-Na Li
Cytokinin oxidase/dehydrogenases (CKXs) play a critical role in the irreversible degradation of cytokinins, thereby regulating plant growth and development. Brassica napus is one of the most widely cultivated oilseed crops worldwide. With the completion of whole-genome sequencing of B. napus , genome-wide identification and expression analysis of the BnCKX gene family has become technically feasible. In this study, we identified 23 BnCKX genes and analyzed their phylogenetic relationships, gene structures, conserved motifs, protein subcellular localizations, and other properties...
March 16, 2018: Genes
Tony Tong-Lin Wu, Yat-Ching Tong, I-Hung Chen, Ho-Shan Niu, Yingxiao Li, Juei-Tang Cheng
The therapeutic action of ginsenoside Rh2 on several cancer models has been reported. This study aimed to evaluate its apoptotic effect on prostate cancer and the underlying mechanism. Cultured DU145 cells were treated with Rh2 (5 × 10-5 to 1 × 10-4 M), peroxisome proliferator-activated receptor-delta (PPAR-delta) antagonist GSK0660 (1 × 10-6 to 5 × 10-6 M); or small interfering RNA (siRNA) of PPAR-delta. The treatment effects were evaluated with cell viability assay, life/death staining and flow cytometry for apoptosis...
February 16, 2018: Oncotarget
Yan Liang, Yang-Kun Chen, Vincent Chung-Tong Mok, De-Feng Wang, Gabor S Ungvari, Winnie Chiu-Wing Chu, Hee-Ju Kang, Wai-Kwong Tang
Objective: All types of cerebral small vessel disease (SVD) markers including lacune, white matter hyperintensities (WMH), cerebral microbleeds, and perivascular spaces were found to be associated with poststroke depressive symptoms (PDS). This study explored whether the combination of the four markers constituting an overall SVD burden was associated with PDS. Methods: A cohort of 563 patients with acute ischemic stroke were followed over a 15-month period after the index stroke. A score of ≥7 on the 15-item Geriatric Depression Scale was defined as clinically significant PDS...
2018: Frontiers in Aging Neuroscience
Jieting Tang, Huarong Chen, Chi-Chun Wong, Dabin Liu, Tong Li, Xiaohong Wang, Jiafu Ji, Joseph Jy Sung, Jing-Yuan Fang, Jun Yu
Copy number alterations (CNAs) are crucial for colorectal cancer (CRC) development. In this study, DEAD box polypeptide 27 (DDX27) was identified to be highly amplified in both TCGA CRC (474/615) and primary CRC (47/103), which was positively correlated with its mRNA overexpression. High DDX27 mRNA (N = 199) and protein expression (N = 260) predicted poor survival in CRC patients. Ectopic expression of DDX27 increased CRC cells proliferation, migration and invasion, but suppressed apoptosis. Conversely, silencing of DDX27 exerted opposite effects in vitro and significantly inhibited murine xenograft tumor growth and lung metastasis in vivo...
March 14, 2018: Oncogene
Jia Wu, Zilin Xu, Yixuan Pan, Yi Shi, Xiujie Bao, Jun Li, Yu Tong, Han Tang, Shuyan Ma, Xuedong Wang, Jianxin Lyu
Herein, a novel magnetic effervescence tablet-assisted microextraction coupled to in situ metathesis reaction of ionic liquid (IS-META-ILDM) is presented for the determination of four endogenous steroids in human urine, pregnant women's blood, and fetal umbilical cord blood. The magnetic effervescent tablets, which were composed of Fe3 O4 nanoparticles, sodium carbonate (alkaline source), and tartaric acid (acidic source), were used to disperse the extractant and for convenient magnetic separation. After the effervescent reaction, in situ reaction between NH4 PF6 and [C6 MIM]BF4 was adopted to change hydrophilic ionic liquid to hydrophobic liquid, which could be separated from the aqueous phase...
March 12, 2018: Analytical and Bioanalytical Chemistry
Tong Tong, Si Chen, Lianrong Wang, You Tang, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee, Shi Chen
The chemical diversity of physiological DNA modifications has expanded with the identification of phosphorothioate (PT) modification in which the nonbridging oxygen in the sugar-phosphate backbone of DNA is replaced by sulfur. Together with DndFGH as cognate restriction enzymes, DNA PT modification, which is catalyzed by the DndABCDE proteins, functions as a bacterial restriction-modification (R-M) system that protects cells against invading foreign DNA. However, the occurrence of dnd systems across a large number of bacterial genomes and their functions other than R-M are poorly understood...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
Lin Gan, Li Shen, Ming Tang, Chen Xing, Yanpeng Li, Changjian Ke, Weijun Tong, Borui Li, Songnian Fu, Deming Liu
We investigate the evolution of the decorrelation bandwidth of intercore crosstalk (IC-XT) based on the modified mode-coupled equations (MCEs) in homogeneous weakly coupled multicore fibers (WC-MCFs). The modified MCEs are numerically solved by combining the fourth order Runge-Kutta method with the compound Simpson integral method. It can be theoretically and numerically observed that the decorrelation bandwidth of IC-XT decreases with transmission distance by fractional linear function. The evolution rule of IC-XT's decorrelation bandwidth is further confirmed by experiments, which can be used as an evaluation criterion for the channel model...
March 5, 2018: Optics Express
Pengfei Zhao, Qingxin Tang, Xiaoli Zhao, Yanhong Tong, Yichun Liu
The application of conductive polymer polypyrrole (PPY) towards transparent and flexible electronics has been demonstrated by a photolithography-compatible technique. The oxygen plasma pretreatment was found to be important for successful fabrication of PPY electrode patterns on flexible poly(ethylene terephthalate) (PET). By the patterning process of PPY, the transparency of PPY electrode can be improved up to >80% over the visible spectrum, which combined with the excellent chemical and physical stability of PPY shows the huge potential of PPY electrode as flexible transparent conductive electrode...
February 23, 2018: Journal of Colloid and Interface Science
Ke Li, Huaying Yan, Wenhao Guo, Mei Tang, Xinyu Zhao, Aiping Tong, Yong Peng, Qintong Li, Zhu Yuan
PTEN deficiency often causes defects in DNA damage repair. Currently, effective therapies for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous studies suggested a synthetic lethality between PTEN and PARP. However, the synthetically lethal interaction between PTEN and ATM in breast cancer has not been reported. Moreover, the mechanism remains elusive. Here, using KU-60019, an ATM kinase inhibitor, we investigated ATM inhibition as a synthetically lethal strategy to target breast cancer cells with PTEN defects...
March 6, 2018: Experimental Cell Research
Zhenling Cui, Hongyan Zhang, Xinping Chen, Chaochun Zhang, Wenqi Ma, Chengdong Huang, Weifeng Zhang, Guohua Mi, Yuxin Miao, Xiaolin Li, Qiang Gao, Jianchang Yang, Zhaohui Wang, Youliang Ye, Shiwei Guo, Jianwei Lu, Jianliang Huang, Shihua Lv, Yixiang Sun, Yuanying Liu, Xianlong Peng, Jun Ren, Shiqing Li, Xiping Deng, Xiaojun Shi, Qiang Zhang, Zhiping Yang, Li Tang, Changzhou Wei, Liangliang Jia, Jiwang Zhang, Mingrong He, Yanan Tong, Qiyuan Tang, Xuhua Zhong, Zhaohui Liu, Ning Cao, Changlin Kou, Hao Ying, Yulong Yin, Xiaoqiang Jiao, Qingsong Zhang, Mingsheng Fan, Rongfeng Jiang, Fusuo Zhang, Zhengxia Dou
Sustainably feeding a growing population is a grand challenge, and one that is particularly difficult in regions that are dominated by smallholder farming. Despite local successes, mobilizing vast smallholder communities with science- and evidence-based management practices to simultaneously address production and pollution problems has been infeasible. Here we report the outcome of concerted efforts in engaging millions of Chinese smallholder farmers to adopt enhanced management practices for greater yield and environmental performance...
March 7, 2018: Nature
Yan-Dong Tang, Jin-Chao Guo, Tong-Yun Wang, Kuan Zhao, Ji-Ting Liu, Jia-Cong Gao, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai
Several groups have used CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) for DNA virus editing. In most cases, one single-guide RNA (sgRNA) is used, which produces inconsistencies in gene editing. In this study, we used a swine herpesvirus, pseudorabies virus, as a model to systematically explore the application of CRISPR/Cas9 in DNA virus editing. In our current report, we demonstrated that cotransfection of 2 sgRNAs and a viral genome resulted in significantly better knockout efficiency than the transfection-infection-based approach...
March 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Hai-Xia Du, Hui-Fen Zhou, Hao-Fang Wan, Jie-Hong Yang, Yi-Yu Lu, Yu He, Hai-Tong Wan
Yinhuapinggan granule (YHPG), a modified prescription based on Ma-Huang-Tang (MHT), is used in traditional Chinese medicine (TCM) to treat influenza, cough, and viral pneumonia. In this study, we investigated the antiviral effects of YHPG by means of pre-, post-, and co-treatment, and its underlying mechanisms on regulating the levels of inflammatory-related cytokines, modulating the mRNA expressions of interferon-stimulated genes in influenza virus-infected murine macrophage cells (RAW264.7), and evaluating the protein expressions of key effectors in the Type I IFN and pattern recognition receptor (PRRs) signaling pathways...
March 3, 2018: Inflammopharmacology
Lu Shen, Guoxing Zhou, Tong Tong, Fei Tang, Yi Lin, Jie Zhou, Yibin Wang, Genlin Zong, Lei Zhang
PURPOSE: To investigate the role of apparent diffusion coefficient (ADC) as an imaging biomarker for invasive ductal carcinoma (IDC) in the breast. METHODS: Seventy-one patients undergoing 3.0 Tesla DWI were retrospectively enrolled. Correlations between the ADC values and prognostic factors were evaluated. RESULTS: Multivariate regression analyses showed that Ki67 expression and molecular subtype were independently associated with the ADC...
February 18, 2018: Clinical Imaging
Jia Liu, Hailang Xiong, Siyuan Tong, Yang Tang, Yongmei Chen, Yanzhi Sun, Xiaojin Yang, Pingyu Wan, Zia Ul Haq Khan
Hydrogen-motivated electrolysis of Na2 CO3 for energy-saving production of NaOH and CO2 /NaHCO3 is realized by the hydrogen oxidation reaction to insert proton into anolyte and the hydrogen evolution reaction to extract proton out of catholyte. Electrolytic voltage at 100 mA cm-2 is as low as 0.88 V; this voltage is only 35% of the voltage used in the traditional electrolysis.
February 28, 2018: Chemical Communications: Chem Comm
Zimin Sun, Huilan Liu, Chenhui Luo, Liangquan Geng, Changcheng Zheng, Baolin Tang, Xiaoyu Zhu, Juan Tong, Xingbing Wang, Kaiyang Ding, Xiang Wan, Lei Zhang, Wen Yao, Kaiding Song, Xuhan Zhang, Yue Wu, Huizhi Yang, Yongsheng Han, Xin Liu, Weibo Zhu, Jingsheng Wu, Zuyi Wang
Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) was added to Bu/Cy and cytarabine (CA) to TBI/Cy for a modified myeloablative conditioning (MMAC). To compare the prognosis of MMAC with MAC, we conducted a retrospective study including 58 patients who underwent CBT with MAC or MMAC from 2000 to 2011...
February 23, 2018: International Journal of Cancer. Journal International du Cancer
Mingfeng Zhang, Jeremy J Racine, Qing Lin, Yuqing Liu, Shanshan Tang, Qi Qin, Tong Qi, Arthur D Riggs, Defu Zeng
Autoimmune type 1 diabetes (T1D) and other autoimmune diseases are associated with particular MHC haplotypes and expansion of autoreactive T cells. Induction of MHC-mismatched but not -matched mixed chimerism by hematopoietic cell transplantation effectively reverses autoimmunity in diabetic nonobese diabetic (NOD) mice, even those with established diabetes. As expected, MHC-mismatched mixed chimerism mediates deletion in the thymus of host-type autoreactive T cells that have T-cell receptor (TCR) recognizing (cross-reacting with) donor-type antigen presenting cells (APCs), which have come to reside in the thymus...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Honghong Tang, Peixia Ye, Shun Wang, Ruida Zhu, Song Su, Luqiong Tong, Chao Liu
[This corrects the article on p. 2033 in vol. 8, PMID: 29218025.].
2018: Frontiers in Psychology
Tong Wen, Yan Zhang, Xue Wang, Guo Tang
BACKGROUND: The intention to leave a job, known as turnover intention, among primary care doctors has a significant impact on primary health care service delivery. We investigated primary care doctors' turnover intention and analysed associated factors involved in primary health facilities in Chongqing, China. METHODS: A total of 440 doctors were interviewed, they were selected using a multi-stage stratified random sampling method. The survey instrument was a self-administered questionnaire which assessed socio-demographic and work-related characteristics, job satisfaction and turnover intention...
February 13, 2018: Human Resources for Health
Yu-Pei Chen, Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P Hui, Anthony Tc Chan, Whee Sze Ong, Tan Terence, Joseph T Wee, Wen-Fei Li, Lei Chen, Brigette B Y Ma, Macy Tong, Sze Huey Tan, Shie-Lee Cheah, Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Ying Guo, Ai-Hua Lin, Ying Sun, Minghuang Hong, Sumei Cao, Mingyuan Chen, Jun Ma
PURPOSE: Due to uneven geographical distribution and small number of randomized trials available, the value of additional induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) remains controversial. This study performed an individual patient data (IPD) pooled analysis to better assess the precise role of IC+CCRT in locoregionally advanced NPC. EXPERIMENTAL DESIGN: Four randomized trials in endemic areas were identified, representing 1,193 patients; updated IPD were obtained...
February 5, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Carlos King Ho Wong, Fangfang Jiao, Eric Ho Man Tang, Thaison Tong, Praveen Thokala, Cindy Lo Kuen Lam
AIMS: Studies have shown that health service utilization often increases in few years immediately before death. Estimates of direct medical cost of diabetes mellitus (DM) in mortality year and the previous year is not well understood. This study aimed to report the health resource use and estimate the direct medical costs among DM patients in the year of mortality and the year before mortality. MATERIALS AND METHODS: We analysed a population-based, retrospective cohort study including all adults with DM diagnosis in Hong Kong between 2009 and 2013, and death between January 1, 2010 and December 31, 2013...
February 12, 2018: Diabetes, Obesity & Metabolism
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