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Tong Tang

Xin-Tong Li, Wei Liao, Hong-Jie Yu, Ming-Wei Liu, Shuai Yuan, Bo-Wen Tang, Xu-Hao Yang, Yong Song, Yao Huang, Shi-le Cheng, Zhi-Yu Chen, Samuel D Towne, Zong-Fu Mao, Qi-Qiang He
BACKGROUND: Unbalanced dietary intake and insufficient physical activity (PA) have been recognized as risk factors for metabolic syndrome (MetS). We aimed to examine the independent and combined effects of fruit and vegetables (FV) intake and PA on MetS. METHODS AND FINDINGS: A cross-sectional survey was conducted among residents of China in 2009, with fasting blood samples collected. Participants were divided into sufficient/insufficient FV intake and adequate/ inadequate PA groups according to self-reported questionnaires...
2017: PloS One
Chengzhong Lin, Wei Cao, Zhenhu Ren, Yu Tang, Chunye Zhang, Rong Yang, Yiming Chen, Zheqi Liu, Canbang Peng, Lizhen Wang, Xu Wang, Tong Ji
Programmed death ligand 1 (PD-L1) functions as a key immune inhibitory factor by binding with its receptor, programmed death 1 (PD-1), to induce immune cell dysfunction and escape of the immune system. However, the mechanisms of PD-L1 expression under growth factor stimulation are not well characterized. Here, we demonstrate a novel role for glial cell line-derived neurotrophic factor (GDNF) in upregulating PD-L1 expression in head and neck squamous cell carcinoma (HNSCC). The expression and correlation of PD-L1, GDNF and perineural invasion (PNI) status were evaluated by bioinformatics analysis of TCGA database and IHC assays from 145 HNSCC patients...
2017: Oncoimmunology
Haibin Xiao, Chuanchen Wu, Ping Li, Wen Gao, Wen Zhang, Wei Zhang, Lili Tong, Bo Tang
As one of the complications of diabetes, liver injury results in significant hazards. Therefore, accurately diagnosing diabetes-induced liver injury beforehand is crucial for the warning and treatment of hepatic diseases. Diabetes-induced liver injury can cause changes in the microstructure and morphology of liver tissue, leading to changes in the hydrophilic and hydrophobic domains in the endoplasmic reticulum (ER), which is closely associated with changes in cellular ER polarity. So, differences in the ER polarity can indicate the degree of diabetes-induced liver injury...
October 1, 2017: Chemical Science
Xiaoli Zhao, Bing Zhang, Qingxin Tang, Xueyan Ding, Shuya Wang, Yuying Zhou, Yanhong Tong, Yichun Liu
Conformal transistor array based on solution-processed organic crystals, which can provide sensory and scanning features for monitoring, biofeedback, and tracking of physiological function, presents one of the most promising technologies for future large-scale low-cost wearable and implantable electronics. However, it is still a huge challenge for the integration of solution-processed organic crystals into conformal FETs owing to a generally existing swelling phenomenon of the elastic materials and the lack of the corresponding device fabrication technology...
November 13, 2017: Scientific Reports
Xiang Dong Luo, Chao-Hua Xue, Yan Li
BACKGROUND: With aging, the feet of the elderly above 60 years old in China present degenerative changes, deformities, and diseases, which significantly affect their daily activities. OBJECTIVES: The authors aimed to study the morphological characteristics of the feet and identify the foot type according to size (length and width) and defect characteristics of elderly feet in China. METHODS: A convenient sample of 1000 subjects above 60 years old was recruited mainly in the regions of Shanghai, Shaanxi, Henan, Hebei, and Sichuan in China...
April 24, 2017: Foot
Li-Hui Cao, Dong Yang, Wei Wu, Xiankun Zeng, Bi-Yang Jing, Meng-Tong Li, Shanshan Qin, Chao Tang, Yuhai Tu, Dong-Gen Luo
Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in olfactory sensory neurons...
November 7, 2017: Nature Communications
Yan-Ling Feng, Xiao-Tong Jiang, Fang-Fang Ma, Jie Han, Xu-Lei Tang
Resveratrol (3,5,4-trihydroxystilbene, RES), a natural antioxidant, prevents bone loss by attenuating damage caused by oxidative stress. Our previous research revealed that the forkhead box O1 (FoxO1)/β-catenin signaling pathway affected the proliferation and differentiation of osteoblasts through its regulation of redox balance, and RES regulated the expression of FoxO1 to control white adipose tissue and then ameliorate an overweight condition. Based on previous research, we hypothesized that RES regulates FoxO1 transcriptional activity through the phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway to achieve an antioxidative effect on osteoporosis and then we confirmed this hypothesis in the present study...
October 23, 2017: International Journal of Molecular Medicine
Min-Ji Tong, Qian Tang, Cheng-Gui Wang, Guang-Heng Xiang, Qi Chen, Hua-Zi Xu, Nai-Feng Tian
BACKGROUD: Some studies have reported that the conventional intersegmental pedicle screws (four-screw fixation, '4S') device for thoracolumbar fractures was associated with inadequate reduction of fractured vertebrae, insufficient correction of kyphosis, and implant failure. Recently, a series of biomechanical studies confirmed that the addition of intermediate fixation screws (six- screw fixation, '6S') could provide stronger fixation and better reduction of fractured vertebrae. Nevertheless, the clinical and radiological efficacy of the additional intermediate screws remains unclear...
November 4, 2017: World Neurosurgery
Shao-Long Lu, Zhi-Hua Ye, Tong Ling, Si-Yuan Liang, Hui Li, Xiao-Zhun Tang, Yan-Song Xu, Wei-Zhong Tang
D-dimer, one of the canonical markers of hypercoagulability, was reported to be a potential prognostic marker of colorectal cancer. However, an inconsistent conclusion existed in several published studies. Thus, we performed this meta-analysis to provide a comprehensive insight into the prognostic role for pretreatment D-dimer in colorectal cancer. Six databases (English: Pubmed, Embase and Web of Science; Chinese: CNKI, Wangfang and VIP) were utilized for the literature retrieval. Hazard ratio (HR) was pooled by Stata 12...
October 6, 2017: Oncotarget
Junfei Guo, Zhen Yang, Xi Yang, Tong Li, Min Liu, Hua Tang
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), which attempts to restore normal function of the ER. Both autophagy and miRNAs have been reported to participate in the process of ER stress, but the relationship between these two factors is still obscure. In this study, we demonstrated that miR-346, which was induced under ER stress, modulated autophagic flux in HeLa cells. By regulating the process of autophagy, miR-346 reduced the ROS level in the cells, thus protecting them from death following ER stress...
October 26, 2017: Cancer Letters
Huan Tong, Yang Tai, Cheng Ye, Hao Wu, Lin-Hao Zhang, Jin-Hang Gao, Zhao-Ping Yan, Zhi-Yin Huang, Cheng-Wei Tang
Tumor markers could increase in both tuberculous peritonitis and peritonitis carcinomatosa, confusing the differentiation of these diseases. This study aimed to better understand the extent of elevation and diagnostic efficacies of carbohydrate antigen 125 (CA 125), carcinoembryonic antigen (CEA) and combinative use of them in tuberculous peritonitis and peritonitis carcinomatosa. Of 2998 patients reviewed, 101, 120 and 71 patients were assigned to TBP group (tuberculous peritonitis), non-OCA group (non-ovarian carcinoma-related peritonitis carcinomatosa) and OCA group (ovarian carcinoma-related peritonitis carcinomatosa), respectively...
September 29, 2017: Oncotarget
Li-Li Ma, Lan Shen, Gui-Hui Tong, Na Tang, Yang Luo, Li-Li Guo, Chun-Ting Hu, Ying-Xin Huang, Guan Huang, Fang-Yan Jing, Chao Liu, Zhuo-Yi Li, Na Zhou, Qian-Wen Yan, Yan Lei, Shi-Jie Zhu, Zhi-Qiang Cheng, Guang-Wen Cao, Yong-Jian Deng, Yan-Qing Ding
Directional migration is a cost-effective movement allowing invasion and metastatic spread of cancer cells. Although migration related to cytoskeletal assembly and microenvironmental chemotaxis has been elucidated, little is known about interaction between extracellular and intracellular molecules for controlling the migrational directionality. A polarized expression of prohibitin (PHB) in the front ends of CRC cells favors metastasis and is correlated with poor prognosis for 545 CRC patients. A high level of vascular endothelial growth factor (VEGF) in the interstitial tissue of CRC patients is associated with metastasis...
September 29, 2017: Oncotarget
Yu-Xi Song, Wen-Yi Tong, Yu-Hao Shen, Shi-Jing Gong, Zheng Tang, Chun-Gang Duan
Considerable progress in contemporary spintronics has been made in recent years for developing nanoscale data memory and quantum information processing. It is, however, still a great challenge to achieve the ultimate limit of storage bit. 2D materials, fortunately, provide an alternative solution for designing materials with the expected miniaturizing scale, chemical stability as well as giant magnetic anisotropy energy. By performing first-principles calculations, we have examined two possible doping sites on a WS2 monolayer using three kinds of transition metal (TM) atoms (Mn, Fe and Co)...
November 2, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Hong-Bo Xu, Tong-Hua Yang, Pei Xie, Shi-Jun Liu, Yan-Ni Liang, Yu Zhang, Zhong-Xing Song, Zhi-Shu Tang
A new pheophytin, (13(2)S, 17S, 18S)-13(2)-hydroxy-20-chloro-ethylpheophorbide a (3), along with two known analogues (1-2) were isolated from the lichen Usnea diffracta Vainio (Parmeliaceae). Among them, compound 3 was a rare C-20-chloro type pheophytin obtained from lichens. Their structures were elucidated by extensive spectroscopic analysis, and all the compounds were obtained for the first time from U. diffracta. Compounds (1-3) were evaluated for their xanthine oxidase (XO) inhibitory activities in vitro, and the results showed that 1-3 possessed significant enzyme inhibitory actions with IC50 values of 46...
November 2, 2017: Natural Product Research
Jiaqian Pan, Shuangmei Tong, Jing Tang
We previously identified a novel inhibitor of La protein, H11, which inhibited hepatitis B virus (HBV) replication by inhibiting the interaction between La protein and HBV RNA. However, the other cellular factors involved in this process remain unclear. To investigate the mechanism of H11-mediated inhibition of HBV infection, a lncRNA microarray analysis was performed using H11-treated and untreated stable HBV-expressing human hepatoblastoma HepG2.2.15 cells. The profiles of differentially expressed lncRNAs and mRNAs were generated and analyzed using Gene Ontology (GO) and pathway analyses...
November 1, 2017: Journal of Viral Hepatitis
Min-Tong Xin, Guang Yang, Xiao-Jing Tang
Ginseng is one of China's valuable Chinese herbal medicines, with a long using history. Ginseng has worldwide reputation, and widely used in food, medicine, health products, cosmetics and other production. China and South Korea have a big ginseng industrial, and sharing half of the export market. The ginseng export competitiveness analysis seems important and necessary between China and South Korea. In this paper, the data of customs and trade of ginseng in COMTRADE database were studied, and ginseng export competitiveness was analyzed between China and Korea...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Huang-Hui Chen, Hsin-Huei Chang, Jang-Yang Chang, Ya-Chu Tang, Yung-Chi Cheng, Li-Mei Lin, Shu-Ying Cheng, Chih-Hsiang Huang, Man-Wu Sun, Chiung-Tong Chen, Ching-Chuan Kuo
Nuclear factor erythroid-2-related factor 2 (NRF2) mainly regulates transcriptional activation through antioxidant-responsive elements (AREs) present in the promoters of NRF2 target genes. Recently, we found that NRF2 was overexpressed in a KB-derived drug-resistant cancer cell panel. In this panel, KB-7D cells, which show acquired resistance to topoisomerase II (Top II) poisons, exhibited the highest NRF2 activation. To investigate whether NRF2 directly contributed to acquired resistance against Top II poisons, we manipulated NRF2 by genetic and pharmacological approaches...
November 2, 2017: Free Radical Biology & Medicine
Haiyang Tang, Aleksandra Babicheva, Kimberly M McDermott, Yali Gu, Ramon J Ayon, Shanshan Song, Ziyi Wang, Akash Gupta, Tong Zhou, Xutong Sun, Swetaleena Dash, Zilu Wang, Angela Balistrieri, Qiu Yu Zheng, Arlette G Cordery, Ankit A Desai, Franz Rischard, Zain Khalpey, Jian Wang, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan
Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration contributes to the elevated PVR in patients with IPAH. Here we report that increased HIF-2α in lung vascular endothelial cells (LVEC) under normoxic conditions is involved in the development of pulmonary hypertension (PH) by inducing endothelial-to-mesenchymal transition (EndMT), which subsequently results in vascular remodeling and occlusive lesions. We observed significant EndMT and markedly increased expression of SNAI, an inducer of EndMT, in LVEC from IPAH patients and PH animals compared with controls...
October 26, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
Hao Li, Pan-He Zhang, Yong Huang, Juan Du, Ning Cui, Zhen-Dong Yang, Fang Tang, Fei-Xiang Fu, Xiao-Mei Li, Xiao-Ming Cui, Ya-Di Fan, Bo Xing, Xiao-Kun Li, Yi-Gang Tong, Wu-Chun Cao, Wei Liu
Background: Rickettsia raoultii was frequently detected in multiple tick species, while human infection remained scarcely studied. Methods: A surveillance study was performed at 3 sentinel hospitals in China, to recruit participants with suspected tick exposure. R. raoultii infection was identified through PCR followed by sequencing and confirmed serologically. Isolation by cell culture was performed and the isolates were genome sequenced. Results: Twenty-six subjects with R...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Lin Li, Ming-Su Liu, Guang-Qin Li, Jie Tang, Yan Liao, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan
OBJECTIVE: Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life. The apolipoprotein (Apo) superfamily, as a group of potentially modifiable biomarkers in clinical practice, is of increasing significance in the diagnosis, evaluation, and prognosis of PD. The present review summarized the current understanding and emerging findings of the relationship between Apo superfamily and PD...
November 5, 2017: Chinese Medical Journal
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