keyword
MENU ▼
Read by QxMD icon Read
search

Tong Tang

keyword
https://www.readbyqxmd.com/read/28938658/comparison-of-direct-sequencing-and-amplification-refractory-mutation-system-for-detecting-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer-patients-a-systematic-review-and-meta-analysis
#1
Qi Feng, Zu-Yao Yang, Jia-Tong Zhang, Jin-Ling Tang
BACKGROUND: Direct sequencing and amplification refractory mutation system (ARMS) are commonly used to detect epidermal growth factor receptor (EGFR) mutation status in patients with non-small-cell lung cancer to inform the decision-making on tyrosine kinase inhibitors treatment. This study aimed to systematically compare the two methods in terms of the rate of detected mutations and the association of detected mutations with clinical outcomes. MATERIAL AND METHODS: PubMed, EMBASE, China National Knowledge Infrastructure (in Chinese) and Wanfang database (in Chinese) were searched to identify relevant studies...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938657/a-network-meta-analysis-on-the-efficacy-of-targeted-agents-in-combination-with-chemotherapy-for-treatment-of-advanced-metastatic-triple-negative-breast-cancer
#2
Long Ge, Yan Tang, Qiu-Ning Zhang, Jin-Hui Tian, Xiao-Hu Wang, Dawid Pieper, Bei Pan, Lun Li, Juan Ling, Zhi-Tong Bing, Ke-Hu Yang
OBJECTIVE: Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS: A total of 15 randomized controlled trials (RCTs), involving 2,410 patients, met our inclusion criteria. Eight targeted agents involving 11 treatment arms were included. The methodological quality of included RCTs was acceptable. The results of direct comparisons showed that progression-free survival (PFS) was significantly longer with bevacizumab+chemotherapy when compared to chemotherapy alone (hazard ratio [HR] = 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28933476/piceatannol-inhibits-the-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritic-chondrocytes-and-ameliorates-osteoarthritis-in-mice-by-activating-nrf2
#3
Qian Tang, Zhenhua Feng, Minji Tong, Jianxiang Xu, Gang Zheng, Liyan Shen, Ping Shang, Yu Zhang, Haixiao Liu
Osteoarthritis (OA) is a complex process, to which an inflammatory environment contributes markedly. Piceatannol exerts anti-inflammatory effects on several diseases. In the current study, we explored the protective effects of piceatannol on the progression of OA and investigated its molecular target. In vitro, piceatannol not only attenuated the over-production of inflammatory mediators and cytokines-such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)-but also suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) at both the mRNA and protein levels...
September 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28919856/visualizing-hyperactivation-in-neurodegeneration-based-on-prefrontal-oxygenation-a-comparative-study-of-mild-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-controls
#4
Kah Hui Yap, Wei Chun Ung, Esther G M Ebenezer, Nadira Nordin, Pui See Chin, Sandheep Sugathan, Sook Ching Chan, Hung Loong Yip, Masashi Kiguchi, Tong Boon Tang
Background: Cognitive performance is relatively well preserved during early cognitive impairment owing to compensatory mechanisms. Methods: We explored functional near-infrared spectroscopy (fNIRS) alongside a semantic verbal fluency task (SVFT) to investigate any compensation exhibited by the prefrontal cortex (PFC) in Mild Cognitive Impairment (MCI) and mild Alzheimer's disease (AD). In addition, a group of healthy controls (HC) was studied. A total of 61 volunteers (31 HC, 12 patients with MCI and 18 patients with mild AD) took part in the present study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28918703/a-randomized-multicenter-clinical-trial-of-rph-with-the-simplified-milligan-morgan-hemorrhoidectomy-in-the-treatment-of-mixed-hemorrhoids
#5
Yong-Heng He, Zhi-Jun Tang, Xiang-Tong Xu, De-Quan Huang, Li-Shun Zhang, Qing-Zhu Tang, Zhi-Min Fan, Xian-Jun Zou, Guo-Jun Zou, Chong-Yang Zhang, Fan Hu, Biao Xie, Yan-Hua Li, Yao Tong, Hong-Chang Liu, Ke Li, Yu-Lian Luo, Fei Liu, Guang-Wei Situ, Zuo-Long Liu
PURPOSE: To explore the safety and efficacy of Ruiyun procedure for hemorrhoids (RPH) or RPH with the simplified Milligan-Morgan hemorrhoidectomy (sMMH) in the treatment of mixed hemorrhoids. METHODS: This is a randomized, controlled, balanced, multicenter study of 3000 patients with mixed hemorrhoids. The outcomes and postoperative complications were compared between 5 types of surgeries. RESULTS: The efficacy rate was the highest in patients who received RPH+sMMH and decreased in the following order: patients who received RPH alone, MMH alone, procedure for prolapse and hemorrhoids (PPH) alone, and PPH+sMMH ( P < ...
September 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28918044/targeted-disruption-of-v600e-mutant-braf-gene-by-crispr-cpf1
#6
Meijia Yang, Heng Wei, Yuelong Wang, Jiaojiao Deng, Yani Tang, Liangxue Zhou, Gang Guo, Aiping Tong
BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) for Cpf1 and Cas9 CRISPR nucleases, respectively. The 1799T > A substitution also leads to the occurrence of a novel NGNG PAM for the EQR variant of Cas9. We examined the editing efficacy and selectivity of Cpf1, Cas9, and EQR variant to this mutation site...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28910912/-percutaneous-catheterization-for-extracorporeal-membrane-oxygenation-a-retrospective-case-series
#7
X Y Li, H Y He, X Tang, R Wang, C Y Zhang, S Q Wang, B Sun, Z H Tong
Objective: To review the experience of percutaneous catheterization for extracorporeal membrane oxygenation (ECMO) by respiratory intensivists at a single institution. Methods: A retrospective review of 87 patients undergoing percutaneous catheterization for ECMO in Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital from November 2009 to January 2017. Subject demographics, type of support, cannulation configuration, types of cannulas, use of imaging modalities, and complications were recorded and summarized...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28905811/first-principles-study-of-enhanced-magnetic-anisotropies-in-transition-metal-atoms-doped-ws-sub-2-sub-monolayer
#8
Yu-Xi Song, Wen-Yi Tong, Yu-Hao Shen, Shijing Gong, Z Tang, Chun-Gang Duan
Considerable progress in contemporary spintronics has been made in recent years for developing nanoscale data memory and quantum information processing. It is, however, still a great challenge to achieve the ultimate limit of storage bit. Two-dimensional materials, fortunately, provide an alternative solution to design materials with the expected miniaturizing scale, the chemical stability as well as the giant magnetic anisotropy energy. By performing first-principles calculations, we have examined two possible doping sites on WS<sub>2</sub> monolayer using three kind of transition metal (TM) atoms (Mn, Fe and Co)...
September 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28903550/combination-of-tumor-volume-and-epstein-barr-virus-dna-improved-prognostic-stratification-of-stage-ii-nasopharyngeal-carcinoma-in-the-imrt-era-a-large-scale-cohort-study
#9
Qiu-Yan Chen, Shao-Yan Guo, Lin-Quan Tang, Tong-Yu Lu, Bo-Lin Chen, Qi-Yu Zhong, Meng-Sha Zou, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
Purpose: Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods: By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28903344/establishing-a-patient-derived-xenograft-model-of-human-myxoid-and-round-cell-liposarcoma
#10
Yiming Qi, Yu Hu, Hua Yang, Rongyuan Zhuang, Yingyong Hou, Hanxing Tong, Yi Feng, Yuan Huang, Quan Jiang, Qunsheng Ji, Qingyang Gu, Zhixiang Zhang, Xuzhen Tang, Weiqi Lu, Yuhong Zhou
Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. A tumor sample from a patient with MRCL was implanted subcutaneously in an immunodeficient mouse shortly after resection to establish a patient-derived tumor xenograft model. After the tumor grew, it was resected and divided into several pieces for re-implantation and tumor passage...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900740/crispr-cas9-mediated-multiple-single-guide-rnas-potently-abrogate-pseudorabies-virus-replication
#11
Yan-Dong Tang, Ji-Ting Liu, Tong-Yun Wang, Ming-Xia Sun, Zhi-Jun Tian, Xue-Hui Cai
Pseudorabies virus (PRV) is a swine herpesvirus that causes significant morbidity and mortality in swine populations and has caused huge economic losses in the worldwide swine industry. Currently, there is no effective antiviral drug in clinical use for PRV infection; it is also difficult to eliminate PRV from infected swine. In our study, we set out to combat these swine herpesvirus infections by exploiting the CRISPR/Cas9 system. We designed 75 single guide RNAs (sgRNA) by targeting both essential and non-essential genes across the genome of PRV...
September 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28898893/effects-of-artesunate-on-the-expressions-of-insulin-like-growth-factor-1-osteopontin-and-c-telopeptides-of-type-ii-collagen-in-a-rat-model-of-osteoarthritis
#12
Zhe Bai, Xiao-Hui Guo, Chi Tang, Si-Tong Yue, Long Shi, Bo Qiang
OBJECTIVE: The study aims to explore the effects of artesunate on insulin-like growth factor-1 (IGF-1), Osteopontin (OPN), and C-telopeptides of type II collagen (CTX-II) in serum, synovial fluid (SF), and cartilage tissues of rats with osteoarthritis (OA). METHODS: OA models were established. Normal model, artesunate, and Viatril-S groups (20 rats respectively) were set. Enzyme-linked immunosorbent assay, IHC staining, and quantitative real-time polymerase chain reaction were conducted to calculate IGF-1, OPN, and CTX-II levels in serum, SF, and cartilage tissues of rats...
September 13, 2017: Pharmacology
https://www.readbyqxmd.com/read/28894020/transcription-factor-oswrky53-positively-regulates-brassinosteroid-signaling-and-plant-architecture
#13
Xiaojie Tian, Xiufeng Li, Wenjia Zhou, Yuekun Ren, Zhenyu Wang, Zhiqi Liu, Jiaqi Tang, Hongning Tong, Jun Fang, Qingyun Bu
Brassinosteroids (BRs) are a class of steroid hormones regulating multiple aspects of plant growth, development, and adaptation. Compared with extensive studies in Arabidopsis, the mechanism of BR signaling in rice is less understood. Here, we identified OsWRKY53, a transcription factor involved in defense responses, as an important regulator of rice BR signaling. Phenotypic analyses showed that OsWRKY53 overexpression led to enlarged leaf angles and increased grain size, in contrast to the erect leaves and smaller seeds in oswrky53 mutant...
September 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28887291/molecular-epidemiology-and-antimicrobial-susceptibility-of-methicillin-resistant-staphylococcus-aureus-isolates-in-xiangyang-china
#14
Yi-Tong Tang, Rui Cao, Na Xiao, Zhi-Shan Li, Rong Wang, Jiu-Ming Zou, Jiao Pei
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) is a public health problem worldwide. This study aimed to investigate the antimicrobial susceptibilities and molecular epidemiological characteristics of MRSA strains in Xiangyang, China, during 2012-2014. METHODS: Eighty non-duplicate S. aureus isolates from clinical specimens were collected from four tertiary hospitals. MRSA strains were identified and tested for antibacterial susceptibility. Staphylococcus cassette chromosome mec (SCCmec) typing, Pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST) and spa typing were performed to explore molecular characteristics...
September 5, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28885699/alteration-of-microrna-profiles-by-a-novel-inhibitor-of-human-la-protein-in-hbv-transformed-human-hepatoma-cells
#15
Jiaqian Pan, Shuangmei Tong, Jing Tang
A pyrazolopyridine HBSC11 was previously identified as a novel inhibitor of human La protein with anti-hepatitis B virus (HBV) activity. However, the underlying mechanism(s) of HBV inhibition by HBSC11 remains unclear. This study aimed to examine the regulation of microRNA (miRNA) by HBSC11 in HBV-transformed human hepatoma HepG2.2.15 cells using microarray and quantitative real-time PCR. Target genes of the differentially expressed miRNAs were predicted and subjected to bioinformatics analysis. Results showed that HBSC11 significantly upregulated the expression of miR-3912-5p, miR-6793-5p, and miR-7159-5p in HepG2...
September 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28881833/lncrna-h19-mediates-bmp9-induced-osteogenic-differentiation-of-mesenchymal-stem-cells-mscs-through-notch-signaling
#16
Junyi Liao, Xinyi Yu, Xue Hu, Jiaming Fan, Jing Wang, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Yasha Li, Wenwen Zhang, Jing Cui, Chao Ma, Li Li, Yichun Yu, Tingting Wu, Xingye Wu, Jiayan Lei, Jia Wang, Chao Yang, Ke Wu, Ying Wu, Jun Tang, Bai-Cheng He, Zhong-Liang Deng, Hue H Luu, Rex C Haydon, Russell R Reid, Michael J Lee, Jennifer Moriatis Wolf, Wei Huang, Tong-Chuan He
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process and regulated by multiple signaling pathways. We previously demonstrated that BMP9 is one of the most potent osteogenic factors. However, molecular mechanism through which BMP9 governs osteoblastic differentiation remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in many physiological and/or pathologic processes...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28872216/perilesional-and-contralateral-white-matter-evolution-and-integrity-in-patients-with-periventricular-nodular-heterotopia-and-epilepsy-a-longitudinal-diffusion-tensor-imaging-study
#17
Wenyu Liu, Bo Yan, Dongmei An, Running Niu, Yingying Tang, Xin Tong, Qiyong Gong, Dong Zhou
BACKGROUND AND PURPOSE: This study aimed to assess the evolution of perinodular and contralateral white matter abnormalities in patients with periventricular nodular heterotopia (PNH) and epilepsy. METHODS: Diffusion tensor imaging (64 direction) and 3T structural MRIs were performed in 29 PNH patients (mean age 27.3 years), and 16 patients underwent a second scan (average time between two scans 1.1 years). Fractional anisotropy and mean diffusivity were measured within the perilesional and contralateral white matter...
September 5, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28871246/succession-and-fermentation-products-of-grass-carp-ctenopharyngodon-idellus-hindgut-microbiota-in-response-to-an-extreme-dietary-shift
#18
Yao Tong Hao, Shan Gong Wu, Fan Xiong, Ngoc T Tran, Ivan Jakovlić, Hong Zou, Wen Xiang Li, Gui Tang Wang
Dietary intake affects the structure and function of microbes in host intestine. However, the succession of gut microbiota in response to changes in macronutrient levels during a long period of time remains insufficiently studied. Here, we determined the succession and metabolic products of intestinal microbiota in grass carp (Ctenopharyngodon idellus) undergoing an abrupt and extreme diet change, from fish meal to Sudan grass (Sorghum sudanense). Grass carp hindgut microbiota responded rapidly to the diet shift, reaching a new equilibrium approximately within 11 days...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28869577/forsythiae-fructus-a-review-on-its-phytochemistry-quality-control-pharmacology-and-pharmacokinetics
#19
REVIEW
Zhanglu Dong, Xianyuan Lu, Xueli Tong, Yaqian Dong, Lan Tang, Menghua Liu
Forsythiae Fructus, as a traditional Chinese medicine, has been widely used both as a single herb and in compound prescriptions in Asia, mainly due to its heat-clearing and detoxifying effects. Modern pharmacology has proved Forsythiae Fructus possesses various therapeutic effects, both in vitro and in vivo, such as anti-inflammatory, antibacterial and antiviral activities. Up to now, three hundred and twenty-one compounds have been identified and sensitive analytical methods have been established for its quality control...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28868952/an-fmri-study-of-the-effects-on-normal-language-areas-when-acupuncturing-the-tongli-ht5-and-xuanzhong-gb39-acupoints
#20
Shuyong Liu, Min Li, Weijun Tang, Guangbin Wang, Yinghui Lv
Objective Functional magnetic resonance imaging (fMRI) analysis of the effects of acupuncturing the Tongli (HT5) and Tongli (HT5)-Xuanzhong (GB39) acupoints on the normal language areas with a view to providing a theoretical basis for using acupuncture to treat patients with aphasia. Methods This study enrolled healthy volunteers. The following acupoints were stimulated: right Tongli (HT5), right Tongli (HT5)-Xuanzhong (GB39), right Tongli (HT5) sham acupuncture, left Tongli (HT5), and left Tongli (HT5)-Xuanzhong (GB39) acupoints...
January 1, 2017: Journal of International Medical Research
keyword
keyword
42391
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"