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Mei Hua Gao

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https://www.readbyqxmd.com/read/29907236/peritoneal-lavage-with-povidone-iodine-solution-in-colorectal-cancer-induced-rats
#1
Hua-Li Song, Dong-Mei Zhang, Heng Wen, Meng Wang, Na Zhao, Yu-Hua Gao, Ni Ding
BACKGROUND: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model. MATERIALS AND METHODS: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29900740/size-and-electronic-modulation-of-iridium-nanoparticles-on-nitrogen-functionalized-carbon-toward-advanced-electrocatalysts-for-alkaline-water-splitting
#2
Hua Wang, Mei Ming, Min Hu, Caili Xu, Yi Wang, Yun Zhang, Daojiang Gao, Jian Bi, Guangyin Fan, Jin-Song Hu
Developing efficient catalytic materials for electrochemical water splitting is important. Herein, uniformly dispersed and size-controllable iridium (Ir) nanoparticles (NPs) were prepared using a nitrogen-functionalized carbon (Ir/CN) as the support. We found that nitrogen function can simultaneously modulate the size of Ir NPs to substantially enhance the catalytically active sites and adjust the electronic structure of Ir, thereby promoting electrocatalytic activity for water splitting. Consequently, the as-synthesized Ir/CN shows excellent electrocatalytic performance with overpotentials of 12 and 265 mV for hydrogen and oxygen evolution reactions in basic medium, respectively...
June 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29888560/-correlation-between-referred-pain-region-and-sensitized-acupoints-in-patients-with-stable-angina-pectoris-and-distribution-of-sensitized-spots-in-rats-with-myocardial-ischemia
#3
Jing Shi, Jian Wang, Yuan Wang, Kun Liu, Yong Fu, Jian-Hua Sun, Ji-Ping Zhao, Xiao-Mei Shao, Si-Feng Feng, You-Wei Yang, Jie Li, Qian-An Cao, Xun He, Mei-Fang Liu, Lu Chen, Xiang Cui, Jiang-Yun Wu, Yuan-Yuan Wu, Xin-Yan Gao, Bing Zhu
OBJECTIVE: To observe the correlation between the referred pain regions of stable angina pectoris (SAP) and the acupoints in coronary heart disease (CHD) patients and to investigate the rule of regional sensitized point distribution in rats. METHODS: A total of 1 046 CHD patients with SAP from 8 hospitals in China were recruited in the present study. The tenderness was palpated along the left and right chest, back, shoulder, upper limb, etc. by a specially-assigned researcher in each hospital...
May 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29876086/genetic-diversity-of-the-chinese-goat-in-the-littoral-zone-of-the-yangtze-river-as-assessed-by-microsatellite-and-mtdna
#4
Guang-Xin E, Yong-Ju Zhao, Li-Peng Chen, Yue-Hui Ma, Ming-Xing Chu, Xiang-Long Li, Qiong-Hua Hong, Lan-Hui Li, Ji-Jun Guo, Lan Zhu, Yan-Guo Han, Hui-Jiang Gao, Jia-Hua Zhang, Huai-Zhi Jiang, Cao-De Jiang, Gao-Fu Wang, Hang-Xing Ren, Mei-Lan Jin, Yuan-Zhi Sun, Peng Zhou, Yong-Fu Huang
The objective of this study was to assess the genetic diversity and population structure of goats in the Yangtze River region using microsatellite and mtDNA to better understand the current status of those goat genetic diversity and the effects of natural landscape in fashion of domestic animal genetic diversity. The genetic variability of 16 goat populations in the littoral zone of the Yangtze River was estimated using 21 autosomal microsatellites, which revealed high diversity and genetic population clustering with a dispersed geographical distribution...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29797242/estrogenic-effects-of-phytoestrogens-derived-from-flemingia-strobilifera-in-mcf-7-cells-and-immature-rats
#5
Si-Yeon Jeong, Minsun Chang, Sang-Ho Choi, Sei-Ryang Oh, Hong-Hua Wu, Yan Zhu, Xiu-Mei Gao, Xiaoying Wang, Baojin Zhang, Da-Sol Lim, Joon Young Lee, So-Dam Kim, Yun Seon Song
Phytoestrogen (PE) has received considerable attention due to the physiological significance of its estrogenicity. Flemingia strobilifera (FS) has been used as a folk medicine in Asia for the treatment of inflammation, cancer, and infection; however, the estrogenic effects and chemical components of FS have not yet been reported. We aimed to uncover the estrogenic properties and PEs derived from FS using phytochemical and pharmacological evaluation. PEs from FS extract (FSE) were analyzed by NMR, HPLC, and MS...
May 24, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29793131/tlr2-4-ligand-amplified-liver-inflammation-promotes-initiation-of-autoimmune-hepatitis-due-to-sustained-il-6-il-12-il-4-il-25-expression
#6
Gang Chi, Xin-Xia Feng, Ying-Xia Ru, Ting Xiong, Yuan Gao, Han Wang, Zhen-Long Luo, Ran Mo, Fang Guo, Yong-Pei He, Gui-Mei Zhang, De-An Tian, Zuo-Hua Feng
Autoimmune hepatitis (AIH), a serious autoimmune liver disease, can be a lifelong illness, leading to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). So far the mechanisms for disease initiation are largely unknown. Here we report that the amplified non-AIH liver inflammation could promote the initiation of AIH due to the sustained increase of IL-6, IL-12, IL-4, and IL-25 in the liver. The liver injury resulting from virus (adenovirus) or chemicals (CCl4 ) could induce an amplified (stronger/long-lasting) hepatic inflammation by releasing the ligands for TLR2/TLR4...
May 21, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29725363/overexpression-of-csk-binding-protein-phosphoprotein-associated-with-glycosphingolipid-enriched-microdomains-induces-cluster-of-differentiation-59-mediated-apoptosis-in-jurkat-cells
#7
Bei-Bei Cong, Mei-Hua Gao, Bing Li, Bing Wang, Bei Zhang, Li-Na Wang, Shu-Chao Zhang, Hua-Qiao Li, Zhong Wang, Shu-Yi Han
Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains (CBP/PAG) is a membrane-bound adaptor protein that downregulates the activation of Src family kinases present in lipid rafts. To elucidate the role of CBP/PAG in human T cell activation, a cell line overexpressing CBP/PAG was constructed and the function of CBP/PAG in Jurkat cells was examined. The present study revealed that increased CBP/PAG expression in T cells significantly enhanced their apoptosis and reduced cellular activation and proliferation...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29719405/microrna-26a-induces-a-mitochondrial-apoptosis-mediated-by-p53-through-targeting-to-inhibit-mcl1-in-human-hepatocellular-carcinoma
#8
Xiao-Mei Gao, Ying Zhu, Jian-Hua Li, Xiang-Yu Wang, Xiao-Fei Zhang, Chen-He Yi, Xin Yang
Aim: We have previously found that microRNA-26a (miR-26a) is a potential tumor suppressor in hepatocellular carcinoma (HCC). In this study, we further explored the roles of miR-26a in HCC apoptosis. Methods: miR-26a expression levels were detected in HCC tissues by real-time PCR. Statistical analysis was performed to explore the correlation between miR-26a expression and apoptotic cells and the antiapoptotic protein levels. In vitro assays were performed to investigate the roles of miR-26a in HCC apoptosis...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29668250/effects-of-baicalein-on-cortical-proinflammatory-cytokines-and-the-intestinal-microbiome-in-senescence-accelerated-mouse-prone-8
#9
Li Gao, Jiaqi Li, Yuzhi Zhou, Xudong Huang, Xuemei Qin, Guanhua Du
Baicalein, a flavonoid derived from the roots of Scutellariae baicalensis Georgi, has shown health benefits for an array of human diseases including dementia. The senescence-accelerated mouse prone 8 (SAMP8) strain is extensively used as a senile dementia model. To further investigate the effects of baicalein in SAMP8 mice, behavioral testing, biochemical detection, and gut microbiota analysis were performed. The results demonstrated that treatment with baicalein ameliorated the senescence status of the SAMP8 mice, as manifested by reducing the grading score of senescence...
April 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29662128/the-extracellular-domain-of-staphylococcus-aureus-ltas-binds-insulin-and-induces-insulin-resistance-during-infection
#10
Yu Liu, Fang-Jie Liu, Zhang-Chun Guan, Fang-Ting Dong, Jian-Hua Cheng, Ya-Ping Gao, Di Li, Jun Yan, Cheng-Hua Liu, Dian-Peng Han, Chun-Mei Ma, Jian-Nan Feng, Bei-Fen Shen, Guang Yang
Insulin resistance is a risk factor for obesity and diabetes and predisposes individuals to Staphylococcus aureus colonization; however, the contribution of S. aureus to insulin resistance remains unclear. Here, we show that S. aureus infection causes impaired glucose tolerance via secretion of an insulin-binding protein extracellular domain of LtaS, eLtaS, which blocks insulin-mediated glucose uptake. Notably, eLtaS transgenic mice (eLtaS trans ) exhibited a metabolic syndrome similar to that observed in patients, including increased food and water consumption, impaired glucose tolerance and decreased hepatic glycogen synthesis...
May 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29607165/a-quality-improvement-program-with-nutrition-therapy-restriction-of-lipid-emulsions-in-cardiac-surgical-patients
#11
Jian Gao, Guo-Wei Tu, Chun-Sheng Wang, Du-Ming Zhu, Lan Liu, Hua Liu, Xiao-Mei Yang, Zhe Luo
Background: To evaluate the effect of restriction of soybean-based intravenous fat emulsions (IVFEs) in clinical outcomes in cardiac surgical patients. Methods: This was a before-and-after interventional study comparing the clinical outcomes regarding the intervention of IVFEs restriction. Before August 2015, parenteral nutrition (PN) using a soy-based lipid emulsion was routinely implemented if patients failed to meet >60% of energy requirements in 48 h post cardiac surgery (Period A)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29581713/effect-of-advanced-age-on-plasma-homocysteine-levels-and-its-association-with-ischemic-stroke-in-non-valvular-atrial-fibrillation
#12
Yan Yao, Li-Jian Gao, Yong Zhou, Jing-Hua Zhao, Qiang Lv, Jian-Zeng Dong, Mei-Sheng Shang
Background: Elevated homocysteine (Hcy) has been reported to be associated with cardiovascular events in atrial fibrillation (AF) patients, while the age-related expression pattern of plasma Hcy in AF remains unknown. The study was aimed to investigate the effect of advanced age on plasma Hcy levels and its association with ischemic stroke in non-valvular AF patients. Methods: A total of 2562 consecutive patients with non-valvular AF and 535 controls were enrolled and divided into six age groups...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29577290/aluminum-and-heavy-metal-accumulation-in-tea-leaves-an-interplay-of-environmental-and-plant-factors-and-an-assessment-of-exposure-risks-to-consumers
#13
Chuan-Yi Peng, Xiao-Hui Zhu, Ru-Yan Hou, Gao-Fei Ge, Ri-Mao Hua, Xiao-Chun Wan, Hui-Mei Cai
Environmental and plant factors (soil condition, variety, season, and maturity) and exposure risks of aluminum (Al), manganese (Mn), lead (Pb), cadmium (Cd), and copper (Cu) in tea leaves were investigated. The concentrations of these metals in tea leaves could not be predicted by their total concentrations in the soil. During any one season, there were differences in Al, Mn, and Cd levels between tea varieties. Seasonally, autumn tea and/or summer tea had far higher levels of Al, Mn, Pb, and Cd than did spring tea...
April 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29563550/structure-of-schlafen13-reveals-a-new-class-of-trna-rrna-targeting-rnase-engaged-in-translational-control
#14
Jin-Yu Yang, Xiang-Yu Deng, Yi-Sheng Li, Xian-Cai Ma, Jian-Xiong Feng, Bing Yu, Yang Chen, Yi-Ling Luo, Xi Wang, Mei-Ling Chen, Zhi-Xin Fang, Fu-Xiang Zheng, Yi-Ping Li, Qian Zhong, Tie-Bang Kang, Li-Bing Song, Rui-Hua Xu, Mu-Sheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao
Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3'-terminus of tRNA at the acceptor stem...
March 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29551296/cd4-foxp3-cd25-tregs-characterize-liver-tissue-specimens-of-patients-suffering-from-drug-induced-autoimmune-hepatitis-a-clinical-pathological-study
#15
Li-Mei Qu, Shu-Hua Wang, Kun Yang, David R Brigstock, Li Sun, Run-Ping Gao
BACKGROUND: The diagnosis of drug-induced autoimmune hepatitis (DIAIH) and its differentiation from idiopathic autoimmune hepatitis (AIH) is challenging. This study aimed to differentiate DIAIH from AIH by comparing the biochemical changes, histological features, and frequencies of CD4+ Foxp3+ CD25+/- regulatory T cells (Tregs) in liver tissues or peripheral blood lymphocytes. METHODS: A total of 15 DIAIH patients and 24 AIH patients who underwent liver biopsies at initial presentation were enrolled in this study...
April 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29544214/dinardokanshones-c-e-isonardoeudesmols-a-d-and-nardoeudesmol-d-from-nardostachys-jatamansi-dc
#16
Hong-Hua Wu, Xu Deng, Hu Zhang, Ying-Peng Chen, Shu-Song Ying, Yi-Jing Wu, Yan-Ting Liu, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Li Li
Dinardokanshones C-E, three sesquiterpenoid dimers comprising an unusual nornardosinane-type sesquiterpenoid core and an aristolane-type sesquiterpenoid unit conjugated by an extra pyran or furan ring, together with monomeric sesquiterpenoids isonardoeudesmols A-D and nardoeudesmol D, were isolated from the underground parts of Nardostachys jatamansi DC. Structures of the eight compounds were elucidated by analysis of the extensive spectroscopic data, and their absolute configurations were established by analysis of NOESY and X-ray diffraction data, combined with computational electronic circular dichroism (ECD) calculations...
June 2018: Phytochemistry
https://www.readbyqxmd.com/read/29541246/a-role-for-gpi-cd59-in-promoting-t-cell-signal-transduction-via-lat
#17
Li-Na Wang, Mei-Hua Gao, Bing Wang, Bei-Bei Cong, Shu-Chao Zhang
Cluster of differentiation 59 (CD59) is a glycosylphosphatidylinositol-anchored protein. Cross-linking of CD59 with specific monoclonal antibodies can cause a series of intracellular signal transduction events. However, the underlying molecular mechanisms are poorly understood. Linker for activation of T-cells (LAT) is a crucial adaptor protein in T-cell signaling, and its phosphorylation and palmitoylation are essential for its localization and function. In a previous study by the present authors, it was demonstrated that CD59 may be responsible for LAT palmitoylation, thereby regulating T-cell signal transduction...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29532850/functions-of-chemokines-in-the-perineural-invasion-of-tumors-review
#18
Mei Zhang, Zhuo-Li Zhu, Xiao-Lei Gao, Jia-Shun Wu, Xin-Hua Liang, Ya-Ling Tang
The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical prognosis. Therefore, it is necessary to investigate novel ligand-receptor crosstalk between nerves and tumor cells that promote the process of PNI. Chemokines are regarded as one of pivotal factors involved in the process of PNI...
March 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29457524/safety-and-effect-on-ablation-size-of-hydrochloric-acid-perfused-radiofrequency-ablation-in-animal-livers
#19
Tian-Qi Zhang, Sen-Miao Huang, Yang-Kui Gu, Fei Gao, Zhi-Mei Huang, Xiong-Ying Jiang, Ding-Xin Liu, Jin-Hua Huang
PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissues, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103 °C and 30 W for 3 min. For each experimental setting, six ablations were created...
February 26, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29457377/pseudohalide-induced-2d-ch-3-nh-3-2-pbi-2-scn-2-perovskite-for-ternary-resistive-memory-with-high-performance
#20
Xue-Feng Cheng, Xiang Hou, Jin Zhou, Bi-Jun Gao, Jing-Hui He, Hua Li, Qing-Feng Xu, Na-Jun Li, Dong-Yun Chen, Jian-Mei Lu
Recently, organic-inorganic hybrid perovskites (OIHP) are studied in memory devices, but ternary resistive memory with three states based on OIHP is not achieved yet. In this work, ternary resistive memory based on hybrid perovskite is achieved with a high device yield (75%), much higher than most organic ternary resistive memories. The pseudohalide-induced 2D (CH3 NH3 )2 PbI2 (SCN)2 perovskite thin film is prepared by using a one-step solution method and fabricated into Al/perovskite film/indium-tin oxide (glass substrate as well as flexible polyethylene terephthalate substrate) random resistive access memory (RRAM) devices...
March 2018: Small
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