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Mei Hua Gao

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https://www.readbyqxmd.com/read/29668250/the-effects-of-baicalein-on-cortical-pro-inflammatory-cytokines-and-the-intestinal-microbiome-in-senescence-accelerated-mouse-prone-8
#1
Li Gao, Jia-Qi Li, Yu-Zhi Zhou, Xudong Huang, Xue-Mei Qin, Guan-Hua Du
Baicalein, a flavonoid derived from the roots of Scutellariae baicalensis Georgi, has shown health benefits for an array of human diseases including dementia. The senescence-accelerated mouse prone 8 (SAMP8) strain is extensively used as a senile dementia model. To further investigate the effects of baicalein in SAMP8 mice, behavioral testing, biochemical detection and gut microbiota analysis were performed. The results demonstrated that treatment with baicalein ameliorated the senescence status of the SAMP8 mice, as manifested by reducing the grading score of senescence...
April 18, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29662128/the-extracellular-domain-of-staphylococcus-aureus-ltas-binds-insulin-and-induces-insulin-resistance-during-infection
#2
Yu Liu, Fang-Jie Liu, Zhang-Chun Guan, Fang-Ting Dong, Jian-Hua Cheng, Ya-Ping Gao, Di Li, Jun Yan, Cheng-Hua Liu, Dian-Peng Han, Chun-Mei Ma, Jian-Nan Feng, Bei-Fen Shen, Guang Yang
Insulin resistance is a risk factor for obesity and diabetes and predisposes individuals to Staphylococcus aureus colonization; however, the contribution of S. aureus to insulin resistance remains unclear. Here, we show that S. aureus infection causes impaired glucose tolerance via secretion of an insulin-binding protein extracellular domain of LtaS, eLtaS, which blocks insulin-mediated glucose uptake. Notably, eLtaS transgenic mice (eLtaS trans ) exhibited a metabolic syndrome similar to that observed in patients, including increased food and water consumption, impaired glucose tolerance and decreased hepatic glycogen synthesis...
April 16, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29607165/a-quality-improvement-program-with-nutrition-therapy-restriction-of-lipid-emulsions-in-cardiac-surgical-patients
#3
Jian Gao, Guo-Wei Tu, Chun-Sheng Wang, Du-Ming Zhu, Lan Liu, Hua Liu, Xiao-Mei Yang, Zhe Luo
Background: To evaluate the effect of restriction of soybean-based intravenous fat emulsions (IVFEs) in clinical outcomes in cardiac surgical patients. Methods: This was a before-and-after interventional study comparing the clinical outcomes regarding the intervention of IVFEs restriction. Before August 2015, parenteral nutrition (PN) using a soy-based lipid emulsion was routinely implemented if patients failed to meet >60% of energy requirements in 48 h post cardiac surgery (Period A)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29581713/effect-of-advanced-age-on-plasma-homocysteine-levels-and-its-association-with-ischemic-stroke-in-non-valvular-atrial-fibrillation
#4
Yan Yao, Li-Jian Gao, Yong Zhou, Jing-Hua Zhao, Qiang Lv, Jian-Zeng Dong, Mei-Sheng Shang
Background: Elevated homocysteine (Hcy) has been reported to be associated with cardiovascular events in atrial fibrillation (AF) patients, while the age-related expression pattern of plasma Hcy in AF remains unknown. The study was aimed to investigate the effect of advanced age on plasma Hcy levels and its association with ischemic stroke in non-valvular AF patients. Methods: A total of 2562 consecutive patients with non-valvular AF and 535 controls were enrolled and divided into six age groups...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29577290/aluminum-and-heavy-metal-accumulation-in-tea-leaves-an-interplay-of-environmental-and-plant-factors-and-an-assessment-of-exposure-risks-to-consumers
#5
Chuan-Yi Peng, Xiao-Hui Zhu, Ru-Yan Hou, Gao-Fei Ge, Ri-Mao Hua, Xiao-Chun Wan, Hui-Mei Cai
Environmental and plant factors (soil condition, variety, season, and maturity) and exposure risks of aluminum (Al), manganese (Mn), lead (Pb), cadmium (Cd), and copper (Cu) in tea leaves were investigated. The concentrations of these metals in tea leaves could not be predicted by their total concentrations in the soil. During any one season, there were differences in Al, Mn, and Cd levels between tea varieties. Seasonally, autumn tea and/or summer tea had far higher levels of Al, Mn, Pb, and Cd than did spring tea...
March 25, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29563550/structure-of-schlafen13-reveals-a-new-class-of-trna-rrna-targeting-rnase-engaged-in-translational-control
#6
Jin-Yu Yang, Xiang-Yu Deng, Yi-Sheng Li, Xian-Cai Ma, Jian-Xiong Feng, Bing Yu, Yang Chen, Yi-Ling Luo, Xi Wang, Mei-Ling Chen, Zhi-Xin Fang, Fu-Xiang Zheng, Yi-Ping Li, Qian Zhong, Tie-Bang Kang, Li-Bing Song, Rui-Hua Xu, Mu-Sheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao
Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3'-terminus of tRNA at the acceptor stem...
March 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29551296/cd4-foxp3-cd25-tregs-characterize-liver-tissue-specimens-of-patients-suffering-from-drug-induced-autoimmune-hepatitis-a-clinical-pathological-study
#7
Li-Mei Qu, Shu-Hua Wang, Kun Yang, David R Brigstock, Li Sun, Run-Ping Gao
BACKGROUND: The diagnosis of drug-induced autoimmune hepatitis (DIAIH) and its differentiation from idiopathic autoimmune hepatitis (AIH) is challenging. This study aimed to differentiate DIAIH from AIH by comparing the biochemical changes, histological features, and frequencies of CD4+ Foxp3+ CD25+/- regulatory T cells (Tregs) in liver tissues or peripheral blood lymphocytes. METHODS: A total of 15 DIAIH patients and 24 AIH patients who underwent liver biopsies at initial presentation were enrolled in this study...
February 19, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29544214/dinardokanshones-c-e-isonardoeudesmols-a-d-and-nardoeudesmol-d-from-nardostachys-jatamansi-dc
#8
Hong-Hua Wu, Xu Deng, Hu Zhang, Ying-Peng Chen, Shu-Song Ying, Yi-Jing Wu, Yan-Ting Liu, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Li Li
Dinardokanshones C-E, three sesquiterpenoid dimers comprising an unusual nornardosinane-type sesquiterpenoid core and an aristolane-type sesquiterpenoid unit conjugated by an extra pyran or furan ring, together with monomeric sesquiterpenoids isonardoeudesmols A-D and nardoeudesmol D, were isolated from the underground parts of Nardostachys jatamansi DC. Structures of the eight compounds were elucidated by analysis of the extensive spectroscopic data, and their absolute configurations were established by analysis of NOESY and X-ray diffraction data, combined with computational electronic circular dichroism (ECD) calculations...
March 12, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29541246/a-role-for-gpi-cd59-in-promoting-t-cell-signal-transduction-via-lat
#9
Li-Na Wang, Mei-Hua Gao, Bing Wang, Bei-Bei Cong, Shu-Chao Zhang
Cluster of differentiation 59 (CD59) is a glycosylphosphatidylinositol-anchored protein. Cross-linking of CD59 with specific monoclonal antibodies can cause a series of intracellular signal transduction events. However, the underlying molecular mechanisms are poorly understood. Linker for activation of T-cells (LAT) is a crucial adaptor protein in T-cell signaling, and its phosphorylation and palmitoylation are essential for its localization and function. In a previous study by the present authors, it was demonstrated that CD59 may be responsible for LAT palmitoylation, thereby regulating T-cell signal transduction...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29532850/functions-of-chemokines-in-the-perineural-invasion-of-tumors-review
#10
Mei Zhang, Zhuo-Li Zhu, Xiao-Lei Gao, Jia-Shun Wu, Xin-Hua Liang, Ya-Ling Tang
The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical prognosis. Therefore, it is necessary to investigate novel ligand-receptor crosstalk between nerves and tumor cells that promote the process of PNI. Chemokines are regarded as one of pivotal factors involved in the process of PNI...
March 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29457524/safety-and-effect-on-ablation-size-of-hydrochloric-acid-perfused-radiofrequency-ablation-in-animal-livers
#11
Tian-Qi Zhang, Sen-Miao Huang, Yang-Kui Gu, Fei Gao, Zhi-Mei Huang, Xiong-Ying Jiang, Ding-Xin Liu, Jin-Hua Huang
PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissue, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103°C and 30 W for 3 minutes. For each experimental setting, 6 ablations were created...
February 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29457377/pseudohalide-induced-2d-ch-3-nh-3-2-pbi-2-scn-2-perovskite-for-ternary-resistive-memory-with-high-performance
#12
Xue-Feng Cheng, Xiang Hou, Jin Zhou, Bi-Jun Gao, Jing-Hui He, Hua Li, Qing-Feng Xu, Na-Jun Li, Dong-Yun Chen, Jian-Mei Lu
Recently, organic-inorganic hybrid perovskites (OIHP) are studied in memory devices, but ternary resistive memory with three states based on OIHP is not achieved yet. In this work, ternary resistive memory based on hybrid perovskite is achieved with a high device yield (75%), much higher than most organic ternary resistive memories. The pseudohalide-induced 2D (CH3 NH3 )2 PbI2 (SCN)2 perovskite thin film is prepared by using a one-step solution method and fabricated into Al/perovskite film/indium-tin oxide (glass substrate as well as flexible polyethylene terephthalate substrate) random resistive access memory (RRAM) devices...
February 19, 2018: Small
https://www.readbyqxmd.com/read/29449128/meta-analysis-on-the-association-between-brain-derived-neurotrophic-factor-polymorphism-rs6265-and-ischemic-stroke-poststroke-depression
#13
Mei-Hua Bao, Shu-Zhen Zhu, Xin-Zheng Gao, Hong-Shuo Sun, Zhong-Ping Feng
BACKGROUND: Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent...
February 13, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29434623/chinese-expert-consensus-on-the-non-invasive-imaging-examination-pathways-of-stable-coronary-artery-disease
#14
Yun-Dai Chen, Wei-Yi Fang, Ji-Yan Chen, Zhan-Ming Fan, Chuan-Yu Gao, Jun-Bo Ge, Zuo-Xiang He, Yong Huo, Lang Li, Si-Jin Li, Xi-Lie Lu, Bin Lv, Ju-Ying Qian, Ya-Jun Shi, Zhu-Jun Shen, Jing Wang, Yi-Ning Wang, Lei Xu, Li Yang, Bo Yu, Mei Zhang, Jun-Jie Yang, Shu-Yang Zhang, Xiao-Li Zhang, Shi-Hua Zhao, Yang Zheng, Yu-Chi Han, Guang Zhi
No abstract text is available yet for this article.
January 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29423997/draft-genome-sequence-of-ramie-boehmeria-nivea-l-gaudich
#15
Ming-Bao Luan, Jian-Bo Jian, Ping Chen, Jun-Hui Chen, Jian-Hua Chen, Qiang Gao, Gang Gao, Ju-Hong Zhou, Kun-Mei Chen, Xuan-Min Guang, Ji-Kang Chen, Qian-Qian Zhang, Xiao-Fei Wang, Long Fang, Zhi-Min Sun, Ming-Zhou Bai, Xiao-Dong Fang, Shan-Cen Zhao, He-Ping Xiong, Chun-Ming Yu, Ai-Guo Zhu
Ramie, Boehmeria nivea (L.) Gaudich, family Urticaceae, is a plant native to eastern Asia, and one of the world's oldest fiber crops. It is also used as animal feed and for the phytoremediation of heavy metal-contaminated farmlands. Thus, the genome sequence of ramie was determined to explore the molecular basis of its fiber quality, protein content, and phytoremediation. For further understanding ramie genome, different paired-end and mate-pair libraries were combined to generate 134.31 Gb of raw DNA sequences using the Illumina whole-genome shotgun sequencing approach...
February 8, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29414036/theoretical-insights-into-imidazolidine-oxidation-of-imidacloprid-by-cytochrome-p450-3a4
#16
Mei Lin Zheng, Chao Rui Li, Qun Hua Bai, Hong Xiao, Wei Hu, Ying Xue, Jie Ying Gao
The metabolic mechanisms for imidazolidine oxidation of imidacloprid (IMI) by cytochrome P450 3A4 (CYP3A4) have been investigated using quantum mechanical/molecular mechanical (QM/MM) calculations. The binding mode of CYP3A4 with IMI is examined by molecular docking in collaboration with molecular dynamics (MD) simulations. The results show that there are six amino acid residues, involving Arg192, Phe195, Ile349, Ala285, Phe284 and Phe88, closely distributed around the IMI. The binding free energy analysis exhibits that the CYP3A4-IMI binding structure is stabilized by electrostatic interaction and van der Waals interaction...
January 12, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29378332/the-histone-demethylase-jmjd3-regulates-zebrafish-myeloid-development-by-promoting-spi1-expression
#17
Shan-He Yu, Kang-Yong Zhu, Fan Zhang, Juan Wang, Hao Yuan, Yi Chen, Yi Jin, Mei Dong, Lei Wang, Xiao-E Jia, Lei Gao, Zhi-Wei Dong, Chun-Guang Ren, Li-Ting Chen, Qiu-Hua Huang, Min Deng, Leonard I Zon, Yi Zhou, Jiang Zhu, Peng-Fei Xu, Ting-Xi Liu
The histone demethylase Jmjd3 plays a critical role in in cell lineage specification and differentiation at various stages of development. However, its function during normal myeloid development remains poorly understood. Here, we carried out a systematic in vivo screen of epigenetic factors for their function in hematopoiesis and identified Jmjd3 as a new epigenetic factor that regulates myelopoiesis in zebrafish. We demonstrated that jmjd3 was essential for zebrafish primitive and definitive myelopoiesis, knockdown of jmjd3 suppressed the myeloid commitment and enhanced the erythroid commitment...
January 26, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29375111/cardiac-nestin-cells-derived-from-early-stage-of-dilated-cardiomyopathy-enhanced-the-survival-of-the-doxorubicin-injured-cardiac-muscle-hl-1-cells
#18
Dongmei Xie, Yan Liao, Binyuan Wu, Yang Chen, Wanwen Lin, Dihan Lu, Shanquan Gao, Shuanghua Zhu, Chaoquan Peng, Mei Hua Jiang
Dilated cardiomyopathy (DCM), as one of the common cardiomyopathies, is a disease of the heart muscle; however, the etiology and pathogenesis of DCM were still poorly understood. Nestin has been reported a special marker of stem/progenitor cells in various tissues, and the tissue resident Nestin+ cells could promote the wound healing and tissue remodeling. However, it remains unclear whether Nestin+ cells participate in the protection of cardiomyocytes during the pathogenesis of DCM. Here the model of mice DCM was induced by doxorubicin (DOX) intraperitoneal injection and observed heart failure and ventricular enlargement via echocardiography and histologic analysis, respectively...
2018: International Heart Journal
https://www.readbyqxmd.com/read/29335064/real-time-assessment-of-cytosolic-mitochondrial-and-nuclear-calcium-levels-change-in-rat-pheochromocytoma-cells-during-pulsed-microwave-exposure-using-a-genetically-encoded-calcium-indicator
#19
Shao Hua Hu, Hui Wang, Li Lu, Hong Mei Zhou, Chang Zhen Wang, Ya Bing Gao, Ji Dong, Rui Yun Peng
Little information is available about the effects of exposure to pulsed microwaves on neuronal Ca2+ signaling under non-thermal conditions. In this study, rat pheochromocytoma (PC12) cells were exposed to pulsed microwaves for 6 min at a specific absorption rate (SAR) of 4 W/kg to assess possible real-time effects. During microwave exposure, free calcium dynamics in the cytosol, mitochondria, and nucleus of cells were monitored by time-lapse microfluorimetry using a genetically encoded calcium indicator (ratiometric-pericam, ratiometric-pericam-mt, and ratiometric-pericam-nu)...
December 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29330507/uncovering-the-anticancer-mechanism-of-compound-kushen-injection-against-hcc-by-integrating-quantitative-analysis-network-analysis-and-experimental-validation
#20
Li Gao, Ke-Xin Wang, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin, Guan-Hua Du
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines, the active compounds, potential targets and pathways involved in these effects have not been systematically investigated. Here, we proposed a novel idea of "main active compound-based network pharmacology" to explore the anti-cancer mechanism of CKI...
January 12, 2018: Scientific Reports
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