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Mei Hua Gao

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https://www.readbyqxmd.com/read/27926532/novel-parp1-2-inhibitor-mefuparib-hydrochloride-elicits-potent-in-vitro-and-in-vivo-anticancer-activity-characteristic-of-high-tissue-distribution
#1
Jin-Xue He, Meng Wang, Xia-Juan Huan, Chuan-Huizi Chen, Shan-Shan Song, Ying-Qing Wang, Xue-Mei Liao, Cun Tan, Qian He, Lin-Jiang Tong, Yu-Ting Wang, Xiao-Hua Li, Yi Su, Yan-Yan Shen, Yi-Ming Sun, Xin-Ying Yang, Yi Chen, Zhi-Wei Gao, Xiao-Yan Chen, Bing Xiong, Xiu-Lian Lu, Jian Ding, Chun-Hao Yang, Ze-Hong Miao
The approval of poly(ADP-ribose) polymerase (PARP) inhibitor AZD2281 in 2014 marked the successful establishment of the therapeutic strategy targeting homologous recombination repair defects of cancers in the clinic. However, AZD2281 has poor water solubility, low tissue distribution and relatively weak in vivo anticancer activity, which appears to become limiting factors for its clinical use. In this study, we found that mefuparib hydrochloride (MPH) was a potent PARP inhibitor, possessing prominent in vitro and in vivo anticancer activity...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925688/rare-deleterious-pard3-variants-in-the-apkc-binding-region-are-implicated-in-the-pathogenesis-of-human-cranial-neural-tube-defects-via-disrupting-apical-tight-junction-formation
#2
Xiaoli Chen, Yu An, Yonghui Gao, Liu Guo, Lei Rui, Hua Xie, Mei Sun, Siv Lam Hung, Xiaoming Sheng, Jizhen Zou, Yihua Bao, Hongyan Guan, Bo Niu, Zandong Li, Richard H Finnell, James F Gusella, Bai-Lin Wu, Ting Zhang
Increasing evidence that mutation of planar cell polarity (PCP) genes contributes to human cranial NTD susceptibility prompted us to hypothesize that rare variants of genes in the core apical-basal polarity (ABP) pathway are risk factors for cranial NTDs. In this study, we screened for rare genomic variation of PARD3 in 138 cranial NTD cases and 274 controls. Overall, the rare deleterious variants of PARD3 were significantly associated with increased risk for cranial NTDs (11/138 vs.7/274, p<0.05, OR = 3...
December 7, 2016: Human Mutation
https://www.readbyqxmd.com/read/27915089/complete-mitochondrial-genome-of-parasitic-nematode-cylicocyclus-nassatus-and-comparative-analyses-with-cylicocyclus-insigne
#3
Yuan Gao, Jian-Hua Qiu, Bing-Bing Zhang, Xin Su, Xue Fu, Dong-Mei Yue, Chun-Ren Wang
Cylicocyclus nassatus is a common and important parasite in the large intestine of equine. In this study, the complete mitochondrial (mt) genome sequence of C. nassatus was determined and comparatively analysed with Cylicocyclus insigne. The mt genome size of C. nassatus was 13,846 bp, 18 bp longer than that of C. insigne. The circular mt genome includes 12 protein-coding genes, two rRNA genes, 22 tRNA genes and two non-coding regions. All the genes are transcribed in the same direction and gene arrangement is consistent with that of gene arrangement 3 (GA3)...
November 30, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27878237/inhibition-of-the-growth-of-human-melanoma-cells-by-methionine-enkephalin
#4
Dong-Mei Wang, Guang-Chuan Wang, Jing Yang, Nicolas P Plotnikoff, Noreen Griffin, Yu-Man Han, Rui-Qun Qi, Xing-Hua Gao, Feng-Ping Shan
Melanoma is an aggressive cancer, the incidence of which is increasing worldwide. Limited therapies are currently available, particularly following metastasis. The aim of the present study was to investigate the inhibiting effect of methionine enkephalin (MENK) on human melanoma via opioid receptors. The results of the present study revealed that MENK markedly regulates the proliferation of A375 cells, causing cell cycle arrest in G0/G1 phase and a decrease in the percentage of cells in S and G2/M phases. Reverse transcription‑quantitative polymerase chain reaction demonstrated that MENK treatment increased opioid receptor expression in A375 cells...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27871879/aging-aggravates-alcoholic-liver-injury-and-fibrosis-in-mice-by-downregulating-sirtuin-1-expression
#5
Teresa Ramirez, Yong-Mei Li, Shi Yin, Ming-Jiang Xu, Dechun Feng, Zhou Zhou, Mengwei Zang, Partha Mukhopadhyay, Zoltan V Varga, Pal Pacher, Bin Gao, Hua Wang
BACKGROUND AND AIMS: Aging is known to exacerbate the progression of alcoholic liver disease (ALD), but the underlying mechanisms remain obscure. METHODS: C57BL/6 mice were subjected to short-term (10-days) ethanol-plus-one binge or long-term (8-weeks) ethanol-plus-multiple binges of ethanol. Liver injury and fibrosis were determined. Hepatic stellate cells (HSCs) were isolated and used in in vitro studies. RESULTS: Compared to young (8-12 weeks) mice, middle-aged (12-14 months) and old (>16 months) mice were more susceptible to liver injury, inflammation, and oxidative stress induced by short-term-plus-one binge or long-term-plus-multiple binges of ethanol feeding...
November 18, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27857756/effects-of-triptolide-on-hippocampal-microglial-cells-and-astrocytes-in-the-app-ps1-double-transgenic-mouse-model-of-alzheimer-s-disease
#6
Jian-Ming Li, Yan Zhang, Liang Tang, Yong-Heng Chen, Qian Gao, Mei-Hua Bao, Ju Xiang, De-Liang Lei
The principal pathology of Alzheimer's disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile plaques, which in turn induce neuroinflammation in the brain. Triptolide, a natural extract from the vine-like herb Tripterygium wilfordii Hook F, has potent anti-inflammatory and immunosuppressive efficacy. Therefore, we determined if triptolide can inhibit activation and proliferation of microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27816643/tetraphenylporphyrin-derivatives-possessing-piperidine-group-as-potential-agents-for-photodynamic-therapy
#7
Ping-Yong Liao, Ying-Hua Gao, Xin-Rong Wang, Lei-Lei Bao, Jun Bian, Tai-Shan Hu, Mei-Zhen Zheng, Yi-Jia Yan, Zhi-Long Chen
Photodynamic therapy (PDT) is a noninvasive therapeutic and promising procedure in cancer treatment and has attracted considerable attention in recent years. In the present paper, 2-piperidinetetraphenylporphyrin derivatives (P1-P3) conjugated with different substituents (Cl, Me, MeO group) at phenyl position were synthesized via nucleophilic substitution of 2-nitroporphyrin copper derivatives with piperidine by refluxing under a nitrogen atmosphere and then demetalization. The combination of (1)H NMR, (13)C NMR and HR-MS was used to elucidate the identities of them...
October 27, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27816501/gapdh-mediated-posttranscriptional-regulations-of-sodium-channel-scn1a-and-scn3a-genes-under-seizure-and-ketogenic-diet-conditions
#8
Guo-Wang Lin, Ping Lu, Tao Zeng, Hui-Ling Tang, Yong-Hong Chen, Shu-Jing Liu, Mei-Mei Gao, Qi-Hua Zhao, Yong-Hong Yi, Yue-Sheng Long
Abnormal expressions of sodium channel SCN1A and SCN3A genes alter neural excitability that are believed to contribute to the pathogenesis of epilepsy, a long-term risk of recurrent seizures. Ketogenic diet (KD), a high-fat and low-carbohydrate treatment for difficult-to-control (refractory) epilepsy in children, has been suggested to reverse gene expression patterns. Here, we reveal a novel role of GAPDH on the posttranscriptional regulation of mouse Scn1a and Scn3a expressions under seizure and KD conditions...
November 2, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27807872/the-modulating-effects-of-cardiac-resynchronization-therapy-on-myocardial-metabolism-in-heart-failure
#9
REVIEW
Chao-Feng Chen, Petras P Dzeja, Yong-Mei Cha, Wei Hua, Bin Chen, Xiao-Fei Gao, Yi-Zhou Xu
BACKGROUND: Heart failure (HF) is associated with changes in cardiac substrate utilization and energy metabolism, including a decline in high-energy phosphate content, mitochondrial dysfunction, and phosphotransfer enzyme deficiency. METHODS AND RESULTS: A shift toward glucose metabolism was noted in the end stage of HF in animals, although HF in humans may not be associated with a shift toward predominant glucose utilization. Deficiencies of micronutrients are well-established causes of cardiomyopathy...
November 3, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27806732/clinical-presentations-and-outcomes-of-patients-with-ebola-virus-disease-in-freetown-sierra-leone
#10
Ying-Jie Ji, Xue-Zhang Duan, Xu-Dong Gao, Lei Li, Chen Li, Dong Ji, Wen-Gang Li, Li-Fu Wang, Yu-Hua Meng, Xiao Yang, Bin-Fang Ling, Xue-Ai Song, Mei-Lei Gu, Tao Jiang, She-Ku M Koroma, James Bangalie, Hui-Juan Duan
BACKGROUND: Clinical and laboratory data were collected and analysed from patients with Ebola virus disease (EVD) in Jui Government Hospital in Freetown, Sierra Leone, where patients with EVD were received and/or treated from October 1, 2014 to March 21, 2015 during the West Africa EVD outbreak. METHODS: The study admitted 285 patients with confirmed EVD and followed them up till the endpoint (recovery or death). EVD was confirmed by quantitative RT-PCR assays detecting blood Ebola virus (EBOV)...
November 3, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27779689/mitochondrial-transcription-factor-a-contributes-to-cisplatin-resistance-in-patients-with-estrogen-receptor%C3%A2-positive-breast-cancer
#11
Wei Gao, Mei-Hong Wu, Ning Wang, Ming-Zheng Ying, Ying-Yi Zhang, Jing Hua, Liu Chuan, Ya-Jie Wang
Previous studies have reported that triple-negative breast cancer is more sensitive to cytotoxic treatment, compared with estrogen receptor (ER)‑positive cancer. However, the underlying molecular mechanisms remain to be fully elucidated. In the present study, we employed reverse transcription‑quantitative polymerase chain reaction, western blot and in vivo assays to investigate the underlying mechanisms. The sensitivities of cells to cisplatin were examined in ER-positive and ER‑negative breast cancer cells, and it was found that the ER‑negative cells were more sensitive to cisplatin, compared with the ER‑positive cells...
October 25, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27753759/electroconvulsive-therapy-in-schizophrenia-in-china-a-national-survey
#12
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Stephen J Seiner, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: Little is known about electroconvulsive therapy (ECT) use in the treatment of schizophrenia in China. This study examined the frequency of ECT use, its trend between 2006 and 2012, and its independent demographic and clinical correlates in a nationwide survey in China. METHODS: A total of 5162 inpatients in 45 Chinese psychiatric hospitals/centers were interviewed (2696 in 2006 and 2466 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
October 7, 2016: Journal of ECT
https://www.readbyqxmd.com/read/27750011/endogenous-polysialic-acid-based-micelles-for-calmodulin-antagonist-delivery-against-vascular-dementia
#13
Xiao-Juan Wang, Yin-Ping Gao, Nan-Nan Lu, Wei-Shuo Li, Ji-Fang Xu, Xiao-Ying Ying, Gang Wu, Mei-Hua Liao, Chao Tan, Ling-Xiao Shao, Ying-Mei Lu, Chen Zhang, Kohji Fukunaga, Feng Han, Yong-Zhong Du
Clinical treatment for vascular dementia still remains a challenge mainly due to Blood-Brain Barrier (BBB). Here, a micelle based on polysialic acid (PSA) which is a hydrophilic and endogenous carbohydrate polymer, was designed to deliver calmodulin antagonist for therapy of vascular dementia. PSA was firstly chemically conjugated with octadecylamine (ODA), and the obtained PSA-ODA copolymer could self-assemble into micelle in aqueous solution with a 120.0 μg/mL critical micelle concentration. The calmodulin antagonist loaded PSA-ODA micelle, featuring sustained drug release behaviour over a period of 72 h with 3...
October 17, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27743380/differential-mirna-expression-in-pleural-effusions-derived-from-extracellular-vesicles-of-patients-with-lung-cancer-pulmonary-tuberculosis-or-pneumonia
#14
Jin Lin, Yan Wang, Ye-Qing Zou, Xin Chen, Bo Huang, Jing Liu, Yan-Mei Xu, Jing Li, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Fan Sun, Shu-Qi Li, Qiu-Fang Gao, Xiao-Zhong Wang
MicroRNAs (miRNAs) have been found to play important regulatory roles in various physiological and pathological processes. MiRNAs also exhibit high stability and are present at high concentrations in human bodily fluids. Consequently, miRNAs may represent attractive and novel diagnostic biomarkers for certain clinical conditions. Recently, the capacity for extracellular vesicles, including microvesicles and exosomes, to carry miRNAs that participate in cell-to-cell communication has been described. In the present study, the miRNA expression patterns for three kinds of pleural effusions that were obtained from patients with pneumonia (group A), pulmonary tuberculosis (group B), and lung cancer (group C) were detected with high-throughput sequencing...
October 14, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27733228/genetic-basis-of-gastric-cancer
#15
Yue-Wen Gao, Chun-Hua Zhang, Xing-Mei Zuo, Xi-Zeng Hui
Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27699250/one-time-injection-of-aav8-encoding-urocortin-2-provides-long-term-resolution-of-insulin-resistance
#16
Mei Hua Gao, Dimosthenis Giamouridis, N Chin Lai, Evelyn Walenta, Vivian Almeida Paschoal, Young Chul Kim, Atsushi Miyanohara, Tracy Guo, Min Liao, Li Liu, Zhen Tan, Theodore P Ciaraldi, Simon Schenk, Aditi Bhargava, Da Young Oh, H Kirk Hammond
Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal within weeks, an effect that lasted for months. Hyperinsulinemic-euglycemic clamps showed reduced plasma insulin, increased glucose disposal rates, and increased insulin sensitivity following UCn2 gene transfer...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27680694/genome-wide-associations-for-birth-weight-and-correlations-with-adult-disease
#17
Momoko Horikoshi, Robin N Beaumont, Felix R Day, Nicole M Warrington, Marjolein N Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R van Zuydam, Kyle J Gaulton, Niels Grarup, Jonathan P Bradfield, David P Strachan, Ruifang Li-Gao, Tarunveer S Ahluwalia, Eskil Kreiner, Rico Rueedi, Leo-Pekka Lyytikäinen, Diana L Cousminer, Ying Wu, Elisabeth Thiering, Carol A Wang, Christian T Have, Jouke-Jan Hottenga, Natalia Vilor-Tejedor, Peter K Joshi, Eileen Tai Hui Boh, Ioanna Ntalla, Niina Pitkänen, Anubha Mahajan, Elisabeth M van Leeuwen, Raimo Joro, Vasiliki Lagou, Michael Nodzenski, Louise A Diver, Krina T Zondervan, Mariona Bustamante, Pedro Marques-Vidal, Josep M Mercader, Amanda J Bennett, Nilufer Rahmioglu, Dale R Nyholt, Ronald C W Ma, Claudia H T Tam, Wing Hung Tam, Santhi K Ganesh, Frank J A van Rooij, Samuel E Jones, Po-Ru Loh, Katherine S Ruth, Marcus A Tuke, Jessica Tyrrell, Andrew R Wood, Hanieh Yaghootkar, Denise M Scholtens, Lavinia Paternoster, Inga Prokopenko, Peter Kovacs, Mustafa Atalay, Sara M Willems, Kalliope Panoutsopoulou, Xu Wang, Lisbeth Carstensen, Frank Geller, Katharina E Schraut, Mario Murcia, Catharina E M van Beijsterveldt, Gonneke Willemsen, Emil V R Appel, Cilius E Fonvig, Caecilie Trier, Carla M T Tiesler, Marie Standl, Zoltán Kutalik, Sílvia Bonàs-Guarch, David M Hougaard, Friman Sánchez, David Torrents, Johannes Waage, Mads V Hollegaard, Hugoline G de Haan, Frits R Rosendaal, Carolina Medina-Gomez, Susan M Ring, Gibran Hemani, George McMahon, Neil R Robertson, Christopher J Groves, Claudia Langenberg, Jian'an Luan, Robert A Scott, Jing Hua Zhao, Frank D Mentch, Scott M MacKenzie, Rebecca M Reynolds, William L Lowe, Anke Tönjes, Michael Stumvoll, Virpi Lindi, Timo A Lakka, Cornelia M van Duijn, Wieland Kiess, Antje Körner, Thorkild I A Sørensen, Harri Niinikoski, Katja Pahkala, Olli T Raitakari, Eleftheria Zeggini, George V Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Mads Melbye, Harry Campbell, James F Wilson, Martine Vrijheid, Eco J C N de Geus, Dorret I Boomsma, Haja N Kadarmideen, Jens-Christian Holm, Torben Hansen, Sylvain Sebert, Andrew T Hattersley, Lawrence J Beilin, John P Newnham, Craig E Pennell, Joachim Heinrich, Linda S Adair, Judith B Borja, Karen L Mohlke, Johan G Eriksson, Elisabeth Widén, Mika Kähönen, Jorma S Viikari, Terho Lehtimäki, Peter Vollenweider, Klaus Bønnelykke, Hans Bisgaard, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Charlotta Pisinger, Oluf Pedersen, Christine Power, Elina Hyppönen, Nicholas J Wareham, Hakon Hakonarson, Eleanor Davies, Brian R Walker, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Struan F A Grant, Allan A Vaag, Debbie A Lawlor, Timothy M Frayling, George Davey Smith, Andrew P Morris, Ken K Ong, Janine F Felix, Nicholas J Timpson, John R B Perry, David M Evans, Mark I McCarthy, Rachel M Freathy
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8))...
September 28, 2016: Nature
https://www.readbyqxmd.com/read/27640088/comparison-of-clinical-efficacy-of-cytarabine-with-different-regimens-in-postremission-consolidation-therapy-for-adult-t-8-21-aml-patients-a-multicenter-retrospective-study-in-china
#18
Dan Gong, Wei Li, Liang-Ding Hu, Jian-Liang Shen, Mei-Yun Fang, Qing-Ming Yang, Heng-Xiang Wang, Xiao-Yan Ke, Hui-Ren Chen, Zhao Wang, Hui Liu, Feng Liu, Yi-Gai Ma, Jing-Wen Wang, Hong-Hua Li, Quan-Shun Wang, Yu Jing, Xiao-Ning Gao, Li-Ping Dou, Yong-Hui Li, Jian-Min Luo, Li Yu
BACKGROUND: The survival of patients with acute myeloid leukemia (AML) with t(8;21) was reported to be shorter in China than in other countries. PATIENTS: We analyzed the correlation between different cytarabine (Ara-c) regimens and outcome in 255 t(8;21) AML patients in China who received postremission consolidation chemotherapy only. RESULTS: The 5-year overall survival (OS) of the high-dose Ara-c group (HDAC; 2≤ Ara-c ≤3 g/m2), intermediate-dose Ara-c group (MDAC; 1...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/27629412/sm22%C3%AE-inhibits-lamellipodium-formation-and-migration-via-ras-arp2-3-signaling-in-synthetic-vsmcs
#19
Pin Lv, Fan Zhang, Ya-Juan Yin, Yu-Can Wang, Min Gao, Xiao-Li Xie, Li-Li Zhao, Li-Hua Dong, Yan-Ling Lin, Ya-Nan Shu, Dan-Dan Zhang, Gui-Xia Liu, Mei Han
We previously demonstrated that smooth muscle (SM) 22α promotes the migration activity in contractile vascular smooth muscle cells (VSMCs). Based on the varied functions exhibited by SM22α in different VSMC phenotypes, we investigated the effect of SM22α on VSMC migration under pathological conditions. The results demonstrated that SM22α overexpression in synthetic VSMCs inhibited platelet-derived growth factor (PDGF)-BB-induced cell lamellipodium formation and migration, which was different from its action in contractile cells...
September 14, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27579785/influence-of-ethnicity-on-the-accuracy-of-non-invasive-scores-predicting-non-alcoholic-fatty-liver-disease
#20
Ming-Feng Xia, Hannele Yki-Järvinen, Hua Bian, Huan-Dong Lin, Hong-Mei Yan, Xin-Xia Chang, You Zhou, Xin Gao
OBJECTIVES: Presence of non-alcoholic fatty liver disease (NAFLD) can predict risks for diabetes, cardiovascular disease and advanced liver disease in the general population. We aimed to establish a non-invasive score for prediction of NAFLD in Han Chinese, the largest ethnic group in the world, and detect whether ethnicity influences the accuracy of such a score. METHODS: Liver fat content (LFAT) was measured by quantitative ultrasound in 3548 subjects in the Shanghai Changfeng Community and a Chinese score was created using multivariate logistic regression analyses...
2016: PloS One
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