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Mei Hua Gao

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https://www.readbyqxmd.com/read/28438669/the-effects-of-chinese-medicines-on-camp-pka-signaling-pathway-in-central-nervous-system-dysfunction
#1
REVIEW
Lin Li, Xiang Fan, Xi-Ting Zhang, Shao-Qian Yue, Zuo-Yan Sun, Jin-Qiang Zhu, Jun-Hua Zhang, Xiu-Mei Gao, Han Zhang
Neuropathological injury in adult mammal central nervous system (CNS) may cause axon disruption, neuronal death and produce lasting neurological deficits. Failure of axon regeneration is one of the major challenges for CNS function recovery. Recently, cAMP/PKA signaling pathway has been proven to be a critical regulator for neuronal regeneration, neuroplasticity and learning and memory ability. And previous studies have revealed the effects of Chinese medicines on prevention and treatment of CNS dysfunction medicated by cAMP/PKA signaling pathway partially...
April 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28427443/benserazide-a-dopadecarboxylase-inhibitor-suppresses-tumor-growth-by-targeting-hexokinase-2
#2
Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang, Hua Li
BACKGROUND: Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a new target for cancer therapy. METHODS: Structure-based virtual ligand screening was used in hit identification from ZINC Drug Database. Microscale thermophoresis assay was performed to evaluate the binding affinity...
April 20, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28421119/influences-of-realgar-indigo-naturalis-a-traditional-chinese-medicine-formula-on-the-main-cyp450-activities-in-rats-using-a-cocktail-method
#3
Huan-Hua Xu, Fei-Ran Hao, Mei-Xi Wang, Si-Jia Ren, Ming Li, Hong-Ling Tan, Yu-Guang Wang, Xiang-Lin Tang, Cheng-Rong Xiao, Qian-De Liang, Yue Gao, Zeng-Chun Ma
The purpose of this work was to study the influences of Realgar-Indigo naturalis (RIF) and its principal element realgar on 4 main cytochrome P450 enzymes activities in rats. A simple and efficient cocktail method was developed to detect the four probe drugs simultaneously. In this study, Wistar rats were administered intragastric RIF and realgar for 14 days; mixed probe drugs were injected into rats by caudal vein. Through analyzing the pharmacokinetic parameter of mixed probe drugs in rats, we can calculate the CYPs activities...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28388148/nonadiabatic-ab-initio-molecular-dynamics-study-of-photoisomerization-in-n-salicilydenemethylfurylamine-smfa
#4
Ai-Hua Gao, Mei-Shan Wang
The photoisomerization mechanisms of N-salicilydenemethylfurylamine upon excitation to the first singlet state are investigated by means of surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Due to different orientations of the methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring, various stable structures are obtained in the optimization. The enol isomer, S0-ENOL-5a, is the most stable conformer. An ultrafast excited-state intramolecular proton transfer is observed after photoexcitation of the most stable enol conformer and then the molecule reaches the excited-state minimum...
March 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28383146/differential-expression-of-urinary-exosomal-micrornas-in-iga-nephropathy
#5
Qing-Hua Min, Xi-Min Chen, Ye-Qing Zou, Jing Zhang, Jing Li, Yan Wang, Shu-Qi Li, Qiu-Fang Gao, Fan Sun, Jing Liu, Yan-Mei Xu, Jin Lin, Lin-Feng Huang, Bo Huang, Xiao-Zhong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis in the world. Reliable biomarkers are required for the non-invasive diagnosis and monitoring of IgAN. This study aims to investigate the difference in urinary exosomal microRNA (miRNA) expression profiles between patients with IgA nephropathy (IgAN) and healthy controls, which may provide clues to identify novel potential non-invasive miRNA biomarkers for renal diseases. METHODS: Urine samples were collected from eighteen healthy controls and eighteen patients with IgAN...
April 6, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28321236/chinese-expert-consensus-on-the-management-of-hypertension-in-the-very-elderly
#6
Jing Li, Yi-Xin Hu, Wen Wang, Ning-Yuan Fang, Xin-Zheng Lu, Lin Pi, Mei-Lin Liu, Wei-Min Li, Yan-Fang Li, Peng Qu, Qi Hua, Qing He, Hai-Ying Wu, Yuan-Ming Zhang, Xiao-Ping Chen, Lu-Yuan Chen, Li Fan, Xing-Sheng Zhao, Zhi-Ming Zhu, Yi-Nong Jiang, Yi-Fang Guo, Hong Yuan, Ping-Jin Gao, Xin-Juan Xu, Jun Cai, Liang-Di Xie
No abstract text is available yet for this article.
December 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28317248/influence-of-different-processing-times-on-the-quality-of-polygoni-multiflora-radix-by-metabolomics-based-on-ultra-high-performance-liquid-chromatography-with-quadrupole-time-of-flight-mass-spectrometry
#7
Xie-An Yu, Ai-Hua Ge, Lu Zhang, Jin Li, Mingrui An, Jun Cao, Jun He, Xiu-Mei Gao, Yan-Xu Chang
A metabolomics method based on ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28294542/pras40-alleviates-neurotoxic-prion-peptide-induced-apoptosis-via-mtor-akt-signaling
#8
Wei Yang, Li-Feng Yang, Zhi-Qi Song, Syed Zahid Ali Shah, Yong-Yong Cui, Chao-Si Li, Hua-Fen Zhao, Hong-Li Gao, Xiang-Mei Zhou, De-Ming Zhao
AIMS: The proline-rich Akt substrate of 40-kDa (PRAS40) protein is a direct inhibitor of mTORC1 and an interactive linker between the Akt and mTOR pathways. The mammalian target of rapamycin (mTOR) is considered to be a central regulator of cell growth and metabolism. Several investigations have demonstrated that abnormal mTOR activity may contribute to the pathogenesis of several neurodegenerative disorders and lead to cognitive deficits. METHODS: Here, we used the PrP peptide 106-126 (PrP(106-126) ) in a cell model of prion diseases (also known as transmissible spongiform encephalopathies, TSEs) to investigate the mechanisms of mTOR-mediated cell death in prion diseases...
May 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28292196/nitration-of-trpm2-as-a-molecular-switch-induces-autophagy-during-brain-pericyte-injury
#9
Quan Jiang, Yinping Gao, Chengkun Wang, Rongrong Tao, Yan Wu, Kaiyu Zhan, Meihua Liao, Nannan Lu, Yingmei Lu, Christopher S Wilcox, Jianhong Luo, Lin-Hua Jiang, Wei Yang, Feng Han
AIMS: Dysfunction of neurovascular pericytes underlies breakdown of the blood-brain barrier, but the molecular mechanisms are largely unknown. In this study, we evaluated the role of the transient receptor potential melastatin-related 2 (TRPM2) channel and autophagy during brain pericyte injury both in vitro and in vivo. RESULTS: A rapid induction in autophagy in human brain vascular pericytes, in the zinc oxide nanoparticles (ZnO-NP)-induced cell stress model, was paralleled with an increase in the expression of the TRPM2-S truncated isoform, which was abolished by treatment with a nitric oxide synthase inhibitor and a peroxynitrite scavenger...
April 18, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28267982/synthesis-of-2-morpholinetetraphenylporphyrins-and-their-photodynamic-activities
#10
Ping-Yong Liao, Xin-Rong Wang, Xiang-Hua Zhang, Tai-Shan Hu, Mei-Zhen Zheng, Ying-Hua Gao, Yi-Jia Yan, Zhi-Long Chen
A series of 2-morpholinetetraphenylporphyrins functionalized with various substituents (Cl, Me, MeO group) at 4-phenyl position were prepared via nucleophilic substitution of 2-nitroporphyrin copper derivatives with morpholine by refluxing under a nitrogen atmosphere and then demetalization. Their basic photophysical properties, intracellular localization, cytotoxicities in vitro and in vivo were also investigated. All synthesized photosensitizers exhibited longer maxima absorption wavelengths than Hematoporphyrin monomethyl ether (HMME)...
February 27, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28257890/a-novel-role-of-fragile-x-mental-retardation-protein-in-pre-mrna-alternative-splicing-through-rna-binding-protein-14
#11
Lin-Tao Zhou, Shun-Hua Ye, Hai-Xuan Yang, Yong-Ting Zhou, Qi-Hua Zhao, Wei-Wen Sun, Mei-Mei Gao, Yong-Hong Yi, Yue-Sheng Long
Fragile X mental retardation protein (FMRP), an important RNA-binding protein responsible for fragile X syndrome, is involved in posttranscriptional control of gene expression that links with brain development and synaptic functions. Here, we reveal a novel role of FMRP in pre-mRNA alternative splicing, a general event of posttranscriptional regulation. Using co-immunoprecipitation and immunofluorescence assays, we identified that FMRP interacts with an alternative-splicing-associated protein RNA-binding protein 14 (RBM14) in a RNA-dependent fashion, and the two proteins partially colocalize in the nuclei of hippocampal neurons...
February 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28229156/protective-effect-of-isoliquiritin-against-corticosterone-induced-neurotoxicity-in-pc12-cells
#12
Yu-Zhi Zhou, Xiao Li, Wen-Xia Gong, Jun-Sheng Tian, Xiao-Xia Gao, Li Gao, Xiang Zhang, Guan-Hua Du, Xue-Mei Qin
Isoliquiritin, a flavonoid glycoside compound from licorice, possesses a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory and anti-depression activities. However, the neuroprotective mechanisms of antidepressant effects remain unclear. In this study, the aim was to investigate the cytoprotective efficiency and potential mechanisms of isoliquiritin in corticosterone-damaged PC12 cells. The results of this study showed that pretreatment of PC12 cells with isoliquiritin significantly prevented corticosterone-induced cell apoptosis...
February 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28209207/recombinant-%C3%AE-actinin-subunit-antigens-of-trichomonas-vaginalis-as-potential-vaccine-candidates-in-protecting-against-trichomoniasis
#13
Yi-Ting Xie, Jiang-Mei Gao, Ya-Ping Wu, Petrus Tang, Geoff Hide, De-Hua Lai, Zhao-Rong Lun
BACKGROUND: Human trichomoniasis caused by Trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. It has caused a series of health problems to patients. For prevention and control of infectious diseases, vaccines are usually considered as one of the most cost-efficient tools. However, until now, work on the development of T. vaginalis vaccines is still mainly focused on the screening of potential immunogens. Alpha-actinin characterized by high immunogenicity in T...
February 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28192186/elevated-expression-of-erbin-destabilizes-er%C3%AE-protein-and-promotes-tumorigenesis-in-hepatocellular-carcinoma
#14
Hua Wu, Su Yao, Shen Zhang, Jing-Ru Wang, Peng-Da Guo, Xiu-Ming Li, Wen-Juan Gan, Lin Mei, Tian-Ming Gao, Jian-Ming Li
BACKGROUND & AIMS: Aberrant estrogen receptor-α (ERα) expression and signaling are implicated in the development of hepatocellular carcinoma (HCC), but its regulation in HCC remains enigmatic. Herein, we aimed to identify a new mechanism by which ERα signaling is regulated in HCC, which may lead to a potential new strategy for HCC therapy. METHODS: Expression levels of Erbin and ERα in human HCC samples were evaluated by immunohistochemistry. In vitro and in vivo experiments were used to assess the effect of Erbin and ERα signaling on HCC cell growth...
February 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28160565/claudin-3-expression-increases-the-malignant-potential-of-lung-adenocarcinoma-cells-role-of-epidermal-growth-factor-receptor-activation
#15
Lianmin Zhang, Yuan Wang, Bin Zhang, Hua Zhang, Meng Zhou, Mei Wei, Qiuping Dong, Yue Xu, Zhaosong Wang, Liuwei Gao, Yanjun Qu, Bowen Shi, Jinfang Zhu, Yuesong Yin, Yulong Chen, Lu Sun, Wei Zhang, Shilei Xu, Guoguang Ying, Changli Wang
Claudins are essential for the formation and maintenance of tight junctions (TJ). The altered expression of claudin proteins has been described in a variety of malignancies. However, the alteration of these proteins in lung adenocarcinoma (ADC) are poorly understood. Therefore, we report, based on the protein expression analysis of a total of 275 patient samples, that claudin-3 (CLDN3) expression is significantly increased in ADC tissues and is associated with cancer progression, correlating significantly with the poor survival of ADC patients (p=0...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28130824/chemical-constituents-from-the-flowers-of-wild-gardenia-jasminoides-ellis
#16
Hu Zhang, Ning Feng, Yan-Tong Xu, Tian-Xiang Li, Xiu-Mei Gao, Yan Zhu, Yun Seon Song, Ya-Nan Wang, Hong-Hua Wu
Four new iridoids, 2'-O-trans-coumaroylshanzhiside (1), 6'-O-trans-coumaroyl- shanzhiside (2), 8α-butylgardenoside B (3), 6α-methoxygenipin (4), and one new phenylpropanoid glucoside, 4-methoxy-benzenepropanol-3-O-β-D-glucopyranoside (5), together with sixteen known compounds, were isolated from the edible flowers of wild Gardenia jasminoides Ellis. Their chemical structures were characterized by extensive spectroscopic techniques, including 1D/2D NMR, HRESIMS, and CD experiments. The absolute configurations of the new isolates' sugar moiety were assigned by HPLC analysis of the acid hydrolysates...
January 28, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28121917/clinical-features-of-benign-epilepsy-of-childhood-with-centrotemporal-spikes-in-chinese-children
#17
MULTICENTER STUDY
Meng-Jia Liu, Xiao-Jun Su, Xiu-Yu Shi Md, Ge-Fei Wu, Yu-Qin Zhang, Li Gao, Wei Wang, Jian-Xiang Liao, Hua Wang, Jian-Ning Mai, Jing-Yun Gao, Xiao-Mei Shu, Shao-Ping Huang, Li Zhang, Li-Ping Zou
This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred.Twenty-five medical centers participate in this clinical trial. The general information, clinical information, and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups was compared, and usefulness of the most commonly used AEDs was evaluated...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28120487/adjunctive-antidepressant-use-in-schizophrenia-in-china-a-national-survey-2002-2012
#18
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: This study examined the pattern of adjunctive antidepressant use in schizophrenia patients and its demographic and clinical correlates in a nationwide survey in China. METHODS: Fourteen thousand and thirteen patients in 45 Chinese psychiatric hospitals or centers were interviewed (4,486 in 2002, 5,288 in 2006, and 4,239 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
January 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28111236/prevalence-of-prediabetes-risk-in-offspring-born-to-mothers-with-hyperandrogenism
#19
Shen Tian, Xian-Hua Lin, Yi-Meng Xiong, Miao-E Liu, Tian-Tian Yu, Min Lv, Wei Zhao, Gu-Feng Xu, Guo-Lian Ding, Chen-Ming Xu, Min Jin, Chun Feng, Yan-Ting Wu, Ya-Jing Tan, Qian Gao, Jian Zhang, Cheng Li, Jun Ren, Lu-Yang Jin, Bin Chen, Hong Zhu, Xue-Ying Zhang, Song-Chang Chen, Xin-Mei Liu, Ye Liu, Jun-Yu Zhang, Li Wang, Ping Zhang, Xiao-Jun Chen, Li Jin, Xi Chen, Yi-Cong Meng, Dan-Dan Wu, Hui Lin, Qian Yang, Cheng-Liang Zhou, Xin-Zhu Li, Yi-Yu Wang, Yu-Qian Xiang, Zhi-Wei Liu, Ling Gao, Lu-Ting Chen, Hong-Jie Pan, Rong Li, Fang-Hong Zhang, Lan-Feng Xing, Yi-Min Zhu, Christian Klausen, Peter C K Leung, Ju-Xue Li, Fei Sun, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. METHODS: Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28094186/nardonaphthalenones-a-and-b-from-the-roots-and-rhizomes-of-nardostachys-chinensis-batal
#20
Xu Deng, Yi-Jing Wu, Ying-Peng Chen, Hong-Hong Zheng, Zhong-Ping Wang, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Hong-Hua Wu
Nardonaphthalenones A and B (1-2), one new apo-α-carotenone (3) and four new monoterpenoids (4, 8-9 and 11), along with six known compounds (5-7, 10, 12-13) were isolated from the dried roots and rhizomes of Nardostachys chinensis Batal. Their structures were elucidated by analysis of the spectroscopic data including NMR, HRESIMS and circular dichroism data. Furthermore, the serotonin transporter (SERT)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on SERT...
January 6, 2017: Bioorganic & Medicinal Chemistry Letters
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