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Mei Hua Gao

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https://www.readbyqxmd.com/read/29223442/exosomes-derived-from-imatinib-resistant-chronic-myeloid-leukemia-cells-mediate-a-horizontal-transfer-of-drug-resistant-trait-by-delivering-mir-365
#1
Qing-Hua Min, Xiao-Zhong Wang, Jing Zhang, Qing-Gen Chen, Shu-Qi Li, Xiao-Qing Liu, Jing Li, Jing Liu, Wei-Ming Yang, Yu-Huan Jiang, Yan-Mei Xu, Jin Lin, Qiu-Fang Gao, Fan Sun, Lei Zhang, Bo Huang
Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem/progenitor cells. Majority of patients can be effectively treated with tyrosine kinase inhibitors (TKIs) such as imatinib, but a portion of patients will develop drug resistance. Accumulated evidences have identified exosomes in cancer as promoters of tumor progression. Herein, we found that exosomes derived from imatinib resistant CML cells can be internalized into sensitive CML cells and confer drug-resistance traits. We also demonstrated a significant higher level of miR-365 in exosomes derived from drug-resistant CML cells compared with those from sensitive ones using microarray and qRT-PCR...
December 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29202512/a-simple-and-rapid-uplc-pda-method-for-quality-control-of-nardostachys-jatamansi
#2
Weize Zhang, Guo Nan, Hong-Hua Wu, Miaomiao Jiang, Tian-Xiang Li, Meng Wang, Xiu-Mei Gao, Yan Zhu, Yun Seon Song, Jiaming Wang, Yan-Tong Xu
Nardostachys jatamansi is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of N. jatamansi. Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of N. jatamansi and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in N. jatamansi. For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of N...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29138574/cancer-cell-dormancy-mechanisms-and-implications-of-cancer-recurrence-and-metastasis
#3
REVIEW
Xiao-Lei Gao, Mei Zhang, Ya-Ling Tang, Xin-Hua Liang
More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential models that can be put forth to explain such process, including angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this review, newly uncovered mechanisms governing cancer cell dormancy are discussed, with an emphasis on the cross talk between dormant cancer cells and their microenvironments...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29118341/novel-serotonin-transporter-regulators-natural-aristolane-and-nardosinane-types-of-sesquiterpenoids-from-nardostachys-chinensis-batal
#4
Ying-Peng Chen, Shu-Song Ying, Hong-Hong Zheng, Yan-Ting Liu, Zhong-Ping Wang, Hu Zhang, Xu Deng, Yi-Jing Wu, Xiu-Mei Gao, Tian-Xiang Li, Yan Zhu, Yan-Tong Xu, Hong-Hua Wu
Serotonin transporter (SERT) is a classic target of drug discovery for neuropsychiatric and digestive disorders, and against those disorders, plants of Nardostachys genus have been valued for centuries in the systems of Traditional Chinese Medicine, Ayurvedic and Unani. Herein, chemical investigation on the roots and rhizomes of Nardostachys chinensis Batal. led to the isolation of forty sesquiterpenoids including six new aristolane-type sesquiterpenoids and six new nardosinane-type sesquiterprenoids. Their structures were elucidated by extensive spectroscopic methods, combined with analyses of circular dichroism and single-crystal X-ray diffraction data...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110391/th2-axis-related-cytokines-in-patients-with-neuromyelitis-optica-spectrum-disorders
#5
Ying Zhang, Xiao-Ying Yao, Mei-Chun Gao, Jie Ding, Rong-Hua Hong, Hua Huang, Lei Zhuang, Yong-Gang Wang, Yong Hao, Yang-Tai Guan
AIMS: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system. Increasing evidence indicates that NMOSD is a Th2- and Th17-dominant disease. IL-25, IL-31, and IL-33 are three newly found Th2-related cytokines, and their roles in the pathogenesis of NMOSD have not been studied. This study aimed to measure the serum levels of IL-25, IL-31, and IL-33 in patients with NMOSD and evaluate their clinical implications. METHODS: Serum was collected from patients with NMOSD (n = 48) and healthy controls (HC, n = 28)...
November 6, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29101162/ex-vivo-profiling-of-pd-1-blockade-using-organotypic-tumor-spheroids
#6
Russell W Jenkins, Amir R Aref, Patrick H Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A Kaplan, Andrew Portell, Prafulla C Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C Thai, Marc R Hammond, Raven Vlahos, Eric S Wang, Hua Zhang, Shuai Li, Glenn J Hanna, Wei Huang, Mai P Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M Cleary, Brian C Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U Barbie, Vivek Sivathanu, Joshua Wong, William G Richards, Raphael Bueno, Charles H Yoon, Juan Miret, Meenhard Herlyn, Levi A Garraway, Eliezer M Van Allen, Gordon J Freeman, Paul T Kirschmeier, Jochen H Lorch, Patrick A Ott, F Stephen Hodi, Keith T Flaherty, Roger D Kamm, Genevieve M Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A Barbie
Ex vivo systems that incorporate features of the tumor microenvironment (TME) and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology and the development of effective combination therapies. Here, we demonstrate the ability to interrogate ex vivo response to ICB using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS). MDOTS/PDOTS isolated from mouse and human tumors retain autologous lymphoid and myeloid cell populations, and respond to ICB in short-term 3-dimensional microfluidic culture...
November 3, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29095265/identification-of-differential-expressed-pe-exosomal-mirna-in-lung-adenocarcinoma-tuberculosis-and-other-benign-lesions
#7
Yan Wang, Yan-Mei Xu, Ye-Qing Zou, Jin Lin, Bo Huang, Jing Liu, Jing Li, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Shu-Qi Li, Qiu-Fang Gao, Fan Sun, Qing-Gen Chen, Lei Zhang, Yu-Huan Jiang, Li-Bin Deng, Xiao-Zhong Wang
Pleural effusion (PE) is a common clinical complication of many pulmonary and systemic diseases, including lung cancer and tuberculosis. Nevertheless, there is no clinical effective biomarker to identify the cause of PE. We attempted to investigate differential expressed exosomal miRNAs in PEs of lung adenocarcinoma (APE), tuberculous (TPE), and other benign lesions (NPE) by using deep sequencing and quantitative polymerase chain reaction (qRT-PCR). As a result, 171 differentiated miRNAs were observed in 3 groups of PEs, and 11 significantly differentiated exosomal miRNAs were validated by qRT-PCR...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093616/radiofrequency-ablation-for-hepatic-hemangiomas-a-consensus-from-a-chinese-panel-of-experts
#8
REVIEW
Jun Gao, Rui-Fang Fan, Jia-Yin Yang, Yan Cui, Jian-Song Ji, Kuan-Sheng Ma, Xiao-Long Li, Long Zhang, Chong-Liang Xu, Xin-Liang Kong, Shan Ke, Xue-Mei Ding, Shao-Hong Wang, Meng-Meng Yang, Jin-Jin Song, Bo Zhai, Chun-Ming Nin, Shi-Gang Guo, Zong-Hai Xin, Jun Lu, Yong-Hong Dong, Hua-Qiang Zhu, Wen-Bing Sun
Recent studies have shown that radiofrequency (RF) ablation therapy is a safe, feasible, and effective procedure for hepatic hemangiomas, even huge hepatic hemangiomas. RF ablation has the following advantages in the treatment of hepatic hemangiomas: minimal invasiveness, definite efficacy, high safety, fast recovery, relatively simple operation, and wide applicability. It is necessary to formulate a widely accepted consensus among the experts in China who have extensive expertise and experience in the treatment of hepatic hemangiomas using RF ablation, which is important to standardize the application of RF ablation for the management of hepatic hemangiomas, regarding the selection of patients with suitable indications to receive RF ablation treatment, the technical details of the techniques, therapeutic effect evaluations, management of complications, etc...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29071898/-distribution-of-press-sensitive-acupoints-in-patients-with-tinnitus
#9
Mei-Qi Ji, Shan-Shan Tian, Dai Liu, Wei Zhang, Jie-Ping Xie, Ya-Li Zhang, Chun-Hua Li, Yan Gao
OBJECTIVE: To explore the regularity of distribution of press-sensitive acupoints on the body surface in tinnitus patients, so as to provide evidence for selecting suitable acupuncture points in the treatment of tinnitus. METHODS: Sixty-three cases of tinnitus patients (from 25 to 75 years in age) were recruited in the present study. The patient was asked to take a sitting, supine and prone position, successively, and the operator used the thumb to moderately press the subject's head, neck, back, four limbs below the knee- and elbow joints along the three Hand- and three Foot-yang and yin meridians...
December 25, 2016: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29063102/stress-related-arterial-hypertension-in-gper-deficient-rats
#10
Ping Luo, Mei-Mei Wu, Po Gao, Ting Gao, Li Dong, Xiao-Wei Ding, You-Qiang Meng, Jia-Hong Qian, Guo-Hua Zhang, Wei-Fang Rong
Numerous studies have demonstrated that estrogens may exert multifaceted effects on the cardiovascular system via activating the classical nuclear receptors ERα or ERβ and the novel G protein coupled estrogen receptor (Gper). However, some studies have reported inconsistent cardiovascular phenotypes in Gper-deficient mice. The current study was aimed to reveal the effects of genetic deletion of Gper on the arterial blood pressure (ABP) and heart rate in rats. Gper-deficient Sprague-Dawley rats were generated by utilizing the CRISPR-Cas9 gene-editing technique...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29022899/transplanted-human-p75-positive-stem-leydig-cells-replace-disrupted-leydig-cells-for-testosterone-production
#11
Min Zhang, Jiancheng Wang, Chunhua Deng, Mei Hua Jiang, Xin Feng, Kai Xia, Weiqiang Li, Xingqiang Lai, Haipeng Xiao, Ren-Shan Ge, Yong Gao, Andy Peng Xiang
Previous studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a promising approach for the treatment of hypogonadism. Here, we isolated human SLCs prospectively and explored the potential therapeutic benefits of human SLC transplantation for hypogonadism treatment. In adult human testes, p75 neurotrophin receptor positive (p75(+)) cells expressed the known SLC marker nestin, but not the LC lineage marker hydroxysteroid dehydrogenase-3β (HSD3β)...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28991531/identification-of-human-cytochrome-p450-and-ugt-enzymes-involved-in-the-metabolism-of-ferulic-acid-a-major-bioactive-component-in-traditional-chinese-medicines
#12
Xiao-Mei Zhuang, Lin Chen, Yan Tan, Hai-Ying Yang, Chuang Lu, Yue Gao, Hua Li
Ferulic acid (FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. However, the metabolic pathways of FA in humans remain unclear. To identify whether human CYP or UGT enzymes are involved in the metabolism of FA, reaction phenotyping of FA was conducted using major CYP-selective chemical inhibitors together with individual CYP and UGT Supersomes. The CYP- and/or UGT-mediated metabolism kinetics were examined simultaneously or individually...
September 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28953624/inflammation-nutrition-scope-predicts-prognosis-of-early-stage-hepatocellular-carcinoma-after-curative-resection
#13
Ying Zhu, Jian-Hua Li, Jing Yang, Xiao-Mei Gao, Hu-Liang Jia, Xin Yang
We developed a novel inflammation-nutrition scope (INS) based on systemic inflammatory response and nutritional status, and explored its prognostic value in hepatocellular carcinoma (HCC), especially for those with early-stage disease.The INS was developed based on a retrospective study of 185 patients with HCC undergoing hepatectomy between 2006 and 2007, and validated in a prospective study of 131 patients enrolled from 2009 to 2010. Prediction accuracy was evaluated with area under the receiver operating characteristic curve (AUCs)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28952270/-effect-of-clinical-doses-of-realgar-indigo-naturalis-formula-and-large-dose-of-realgar-on-cyp450s-of-rat-liver
#14
Huan-Hua Xu, Mei-Xi Wang, Hong-Ling Tan, Yu-Guang Wang, Xiang-Lin Tang, Cheng-Rong Xiao, Hua Li, Yue Gao, Zeng-Chun Ma
To investigate the effect of clinical dose of Realgar-Indigo Naturais formula (RIF) and large-dose of Realgar on main drug-metabolizing enzymes CYP450s of rat liver, as well as its regulatory effect on mRNA expression. Wistar rats were administrated orally with tested drugs for 14 days. A Cocktail method combined with HPLC-MS/MS was used in the determination of 4 cytochrome P450 isozymes (CYP1A2, CYP2B, CYP3A and CYP2C) in liver of the rats, and the mRNA expression levels of the above subtypes were detected by real-time fluorescent quantitative PCR...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28943032/formaldehyde-inhibits-sexual-behavior-and-expression-of-steroidogenic-enzymes-in-the-testes-of-mice
#15
Zhi-Jun Zang, You-Qiang Fang, Su-Yun Ji, Yong Gao, Yuan-Qiang Zhu, Ting-Ting Xia, Mei-Hua Jiang, Ya-Nan Zhang
BACKGROUND: Formaldehyde, a ubiquitous environmental pollutant, is used extensively and has been proved to impair male reproduction in mammals. However, no trials have explored whether formaldehyde affects sexual function. AIM: To evaluate the effect of long-term formaldehyde exposure on sexual behavior and to investigate the potential mechanism. METHODS: Forty C57BL/6 male mice were randomly allocated to four equally sized groups. Mice were exposed to formaldehyde at a dose of 0 (control), 0...
September 21, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28940447/comprehensive-survey-of-vitiligo-patients-in-the-northeast-of-china-using-a-predesigned-questionnaire
#16
Zheng Lin, Yaping Tian, Bingxue Bai, Mei Liu, Yan Wu, Bihuan Xiao, Xing-Hua Gao, Hong-Duo Chen
To assess the sociodemographic data and clinical information of outpatients affected by vitiligo in the northeast of China, vitiligo patients or guardians who presented to the clinic were invited to participate in an exploratory questionnaire. The questionnaire consisted of two sections related to vitiligo, including sociodemographic data and clinical information. A total of 983 vitiligo patients answered the questionnaire. The rates of female and male patients were comparable. The investigated patients were mostly young and middle-aged...
September 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28918019/dual-tumor-targeting-nanocarrier-system-for-sirna-delivery-based-on-prna-and-modified-chitosan
#17
Lin Li, Xiaoqin Hu, Min Zhang, Siyu Ma, Fanglin Yu, Shiqing Zhao, Nan Liu, Zhiyuan Wang, Yu Wang, Hua Guan, Xiujie Pan, Yue Gao, Yue Zhang, Yan Liu, Yang Yang, Xuemei Tang, Mingyuan Li, Cheng Liu, Zhiping Li, Xingguo Mei
Highly specific and efficient delivery of siRNA is still unsatisfactory. Herein, a dual tumor-targeting siRNA delivery system combining pRNA dimers with chitosan nanoparticles (CNPPs) was designed to improve the specificity and efficiency of siRNA delivery. In this dual delivery system, folate-conjugated and PEGylated chitosan nanoparticles encapsulating pRNA dimers were used as the first class of delivery system and would selectively deliver intact pRNA dimers near or into target cells. pRNA dimers simultaneously carrying siRNA and targeting aptamer, the second class of delivery system, would specifically deliver siRNA into the target cells via aptamer-mediated endocytosis or proper particle size...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28881473/the-classic-signalling-and-trans-signalling-of-interleukin-6-are-both-injurious-in-podocyte-under-high-glucose-exposure
#18
Chun-Tao Lei, Hua Su, Chen Ye, Hui Tang, Pan Gao, Cheng Wan, Fang-Fang He, Yu-Mei Wang, Chun Zhang
Interleukin-6 (IL-6) is a multifunctional cytokine that employs IL-6 classic and trans-signalling pathways, and these two signal channels execute different or even opposite effects in certain diseases. As a cardinal event of diabetic kidney disease (DKD), whether the podocyte abnormalities are associated with IL-6 signalling, especially classic or trans-signalling respectively, remains unclear. In this study, we identified that the circulatory IL-6, soluble IL-6R (sIL-6R) and soluble glycoprotein 130 (sgp130) levels are elevated in patients with DKD...
September 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28878233/a-chalcone-derivative-reactivates-latent-hiv-1-transcription-through-activating-p-tefb-and-promoting-tat-sec-interaction-on-viral-promoter
#19
Jun Wu, Ming-Tao Ao, Rui Shao, Hui-Ru Wang, Diao Yu, Mei-Juan Fang, Xiang Gao, Zhen Wu, Qiang Zhou, Yu-Hua Xue
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835711/development-of-a-versatile-and-conventional-technique-for-gene-disruption-in-filamentous-fungi-based-on-crispr-cas9-technology
#20
Yan-Mei Zheng, Fu-Long Lin, Hao Gao, Gen Zou, Jiang-Wei Zhang, Gao-Qian Wang, Guo-Dong Chen, Zhi-Hua Zhou, Xin-Sheng Yao, Dan Hu
Filamentous fungi represent an invaluable source of pharmaceutically active compounds. The development of versatile methods to genetically manipulate filamentous fungi is of great value for improving the low yields of bioactive metabolites and expanding chemical diversity. The CRISPR-Cas9-based system has become a common platform for genome editing in a variety of organisms. However, recent application of this technology in filamentous fungi is limited to model strains, a versatile method for efficient gene disruption in different fungi is lacking...
August 23, 2017: Scientific Reports
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