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Yingxu Zhang, Yingzi Li, Zihang Song, Rui Lin, Yifu Chen, Jianqiang Qian
A quartz tuning fork (QTF) has been widely used as a force sensor of the frequency modulation atomic force microscope due to its ultrahigh stiffness, high quality factor and self-sensing nature. However, due to the bulky structure and exposed surface electrode arrangement, its application is limited, especially in liquid imaging of in situ biological samples, ionic liquids, electrochemical reaction, etc. Although the complication can be resolved by coating insulating materials on the QTF surface and then immersing the whole QTF into the liquid, it would result in a sharp drop of the quality factor, which will reduce the sensitivity of the QTF...
May 19, 2018: Sensors
B Amoutzopoulos, T Steer, C Roberts, J E Cade, C J Boushey, C E Collins, E Trolle, E J de Boer, N Ziauddeen, C van Rossum, E Buurma, D Coyle, P Page
The aim of the present paper is to summarise current and future applications of dietary assessment technologies in nutrition surveys in developed countries. It includes the discussion of key points and highlights of subsequent developments from a panel discussion to address strengths and weaknesses of traditional dietary assessment methods (food records, FFQ, 24 h recalls, diet history with interviewer-assisted data collection) v. new technology-based dietary assessment methods (web-based and mobile device applications)...
2018: Journal of Nutritional Science
Erin E Buckels, Paul D Trapnell, Tamara Andjelovic, Delroy L Paulhus
OBJECTIVE: To clarify the association between online trolling and sadistic personality; and provide evidence that the reward and rationalization processes at work in sadism are likewise manifest in online trolling. METHOD: Online respondents (total N = 1,715) completed self-report measures of personality and trolling behavior. They subsequently engaged in one of two judgment tasks. In Study 1, respondents viewed stimuli depicting scenes of emotional/physical suffering, and provided ratings of (a) perceived pain intensity and (b) pleasure experienced while viewing the photos...
April 16, 2018: Journal of Personality
Elin Roos, Alessandra Grotta, Fei Yang, Rino Bellocco, Weimin Ye, Hans-Olov Adami, Karin Wirdefeldt, Ylva Trolle Lagerros
OBJECTIVE: Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures. METHODS: We prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs)...
April 17, 2018: Neurology
Kyomi D Gregory, Janna B Oetting
Purpose: We compared teacher ratings as measured by the Teacher Rating of Oral Language and Literacy (TROLL; Dickinson, McCabe, & Sprague, 2001, 2003) and Children's Communication Checklist-Second Edition (CCC-2; Bishop, 2006) to 2 established screeners, the Part II of the Diagnostic Evaluation of Language Variation-Screening Test (DELV-ST-II; Seymour, Roeper, & de Villiers, 2003) and Dynamic Indicators of Basic Early Literacy Skills-Next (DIBELS; Good, Gruba, & Kaminski, 2009), and then examined whether teacher ratings alone or when combined with the DELV-ST-II or DIBELS accurately classify nonmainstream English-speaking kindergartners by their clinical status...
April 5, 2018: Language, Speech, and Hearing Services in Schools
Ehsan Dehghan, Shyam Bharat, Cynthia Kung, Antonio Bonillas, Luc Beaulieu, Jean Pouliot, Jochen Kruecker
PURPOSE: Intraoperative dosimetry in low-dose-rate (LDR) permanent prostate brachytherapy requires accurate localization of the implanted seeds with respect to the prostate anatomy. Transrectal Ultrasound (TRUS) imaging, which is the main imaging modality used during the procedure, is not sufficiently robust for accurate seed localization. We present a method for integration of electromagnetic (EM) track-ing into LDR prostate brachytherapy procedure by fusing it with TRUS imaging for seed localization...
March 31, 2018: Medical Physics
Mohammadreza Sajjadi, Hossein Nejat Pishkenari, Gholamreza Vossoughi
Trolling mode atomic force microscopy (TR-AFM) has overcome many imaging problems in liquid environments by considerably reducing the liquid-resonator interaction forces. The finite element model of the TR-AFM resonator considering the effects of fluid and nanoneedle flexibility is presented in this research, for the first time. The model is verified by ABAQUS software. The effect of installation angle of the microbeam relative to the horizon and the effect of fluid on the system behavior are investigated. Using the finite element model, frequency response curve of the system is obtained and validated around the frequency of the operating mode by the available experimental results, in air and liquid...
March 14, 2018: Ultramicroscopy
Elly Mertens, Anneleen Kuijsten, Marcela Dofková, Lorenza Mistura, Laura D'Addezio, Aida Turrini, Carine Dubuisson, Sandra Favret, Sabrina Havard, Ellen Trolle, Pieter Van't Veer, Johanna M Geleijnse
PURPOSE: Public health policies and actions increasingly acknowledge the climate burden of food consumption. The aim of this study is to describe dietary intakes across four European countries, as baseline for further research towards healthier and environmentally-friendlier diets for Europe. METHODS: Individual-level dietary intake data in adults were obtained from nationally-representative surveys from Denmark and France using a 7-day diet record, Italy using a 3-day diet record, and Czech Republic using two replicates of a 24-h recall...
March 28, 2018: European Journal of Nutrition
Sten O Nilsson Lill, Cory M Widdifield, Anna Pettersen, Anna Svensk Ankarberg, Maria Lindkvist, Peter Aldred, Sandra Gracin, Norman Shankland, Kenneth Shankland, Staffan Schantz, Lyndon Emsley
By the combined use of powder and single-crystal X-ray diffraction, solid-state NMR, and molecular modeling, the crystal structures of two systems containing the unusually large tenapanor drug molecule have been determined: the free form, ANHY, and a dihydrochloride salt form, 2HCl. Dynamic nuclear polarization (DNP) assisted solid-state NMR (SSNMR) crystallography investigations were found essential for the final assignment and were used to validate the crystal structure of ANHY. From a structural informatics analysis of ANHY and 2HCl, conformational ring differences in one part of the molecule were observed which influence the relative orientation of a methyl group on a ring nitrogen and thereby impact the crystallizability of the dihydrochloride salt...
April 2, 2018: Molecular Pharmaceutics
Joshua V Troll, M Kristina Hamilton, Melissa L Abel, Julia Ganz, Jennifer M Bates, W Zac Stephens, Ellie Melancon, Michiel van der Vaart, Annemarie H Meijer, Martin Distel, Judith S Eisen, Karen Guillemin
Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein...
February 23, 2018: Development
Emma Christine Jappe, Jens Kringelum, Thomas Trolle, Morten Nielsen
Peptides that bind to and are presented by MHC class I and class II molecules collectively make up the immunopeptidome. In the context of vaccine development, an understanding of the immunopeptidome is essential, and much effort has been dedicated to its accurate and cost-effective identification. Current state-of-the-art methods mainly comprise in silico tools for predicting MHC binding, which is strongly correlated with peptide immunogenicity. However, only a small proportion of the peptides that bind to MHC molecules are, in fact, immunogenic, and substantial work has been dedicated to uncovering additional determinants of peptide immunogenicity...
February 15, 2018: Immunology
Yongjun Men, Wei Li, Geert-Jan Janssen, Roger S M Rikken, Daniela A Wilson
Accurate control of the shape transformation of polymersome is an important and interesting challenge that spans across disciplines such as nanomedicine and nanomachine. Here, we report a fast and facile methodology of shape manipulation of polymersome via out-of-equilibrium polymer self-assembly and shape change by chemical addition of additives. Due to its increased permeability, hydrophilicity, and fusogenic properties, poly(ethylene oxide) was selected as the additive for bringing the system out of equilibrium via fast addition into the polymersome organic solution...
March 14, 2018: Nano Letters
Essi Hantikainen, Marie Löf, Alessandra Grotta, Ylva Trolle Lagerros, Mauro Serafini, Rino Bellocco, Elisabete Weiderpass
Foods rich in antioxidants have been associated with a reduced risk of myocardial infarction. However, findings from randomized clinical trials on the role of antioxidant supplementation remain controversial. It has been suggested that antioxidants interact with each other to promote cardiovascular health. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), measuring the total antioxidant potential of the whole diet, and the risk of myocardial infarction. We followed 45,882 women aged 30-49 years and free from cardiovascular diseases through record linkages from 1991 until 2012...
February 2018: European Journal of Epidemiology
Christian Trolle, Sanne Fisker
No abstract text is available yet for this article.
January 22, 2018: Ugeskrift for Laeger
Taehoon H Kim, Young Ki Hahn, Jungmin Lee, Danny van Noort, Minseok S Kim
As paper-based diagnostics has become predominantly driven by more advanced microfluidic technology, many of the research efforts are still focused on developing reliable and versatile fluidic control devices, apart from improving sensitivity and reproducibility. In this work, we introduce a novel and robust paper fluidic control system enabling versatile fluidic control. The system comprises a linear push-pull solenoid and an Arduino Uno microcontroller. The precisely controlled pressure exerted on the paper stops the flow...
February 20, 2018: Analytical Chemistry
Tove Lise Nielsen, Niels Trolle Andersen, Kirsten Schultz Petersen, Helene Polatajko, Claus Vinther Nielsen
BACKGROUND: There is growing interest in enabling older adults' occupational performance. We tested whether 11 weeks of intensive client-centred occupational therapy (ICC-OT) was superior to usual practice in improving the occupational performance of home-dwelling older adults. METHODS: An assessor-masked randomized controlled trial among adults 60 + with chronic health issues, who received or applied for homecare services. Recruitment took place September 2012 to April 2014...
January 12, 2018: Scandinavian Journal of Occupational Therapy
Stephanie E Bonn, Christina Alexandrou, Kristin Hjörleifsdottir Steiner, Klara Wiklander, Claes-Göran Östenson, Marie Löf, Ylva Trolle Lagerros
BACKGROUND: Physical activity can decrease the risk of complications related to diabetes type 2. Feasible and scalable strategies to implement support for a healthy lifestyle for patients in primary care are needed. The aim of the DiaCert-study is to evaluate a digital healthcare platform and the effect of a 12-week long smartphone-app physical activity intervention aiming at increasing physical activity (primary outcome) and improve levels of HbA1c (glycated hemoglobin), blood lipids, blood pressure, body composition, as well as other lifestyle factors and overall health in patients with diabetes type 2...
January 10, 2018: BMC Public Health
Francesca Ghilotti, Ann-Sofie Pesonen, Sara E Raposo, Henric Winell, Olof Nyrén, Ylva Trolle Lagerros, Amelie Plymoth
OBJECTIVES: Previous studies found higher levels of physical activity to be protective against infections and that short and long sleep negatively affects the immune response. However, these relationships remain debatable. We aimed to investigate if physical activity and sleep habits affect incidence of upper respiratory tract infections (URTI) in a prospective cohort study. METHODS: A total of 2,038 adults aged 25-64 years served as a random sample of the gainfully employed population of an industrial town in Sweden...
2018: PloS One
Massimo Andreatta, Thomas Trolle, Zhen Yan, Jason A Greenbaum, Bjoern Peters, Morten Nielsen
Motivation: Computational methods for the prediction of peptide-MHC binding have become an integral and essential component for candidate selection in experimental T cell epitope discovery studies. The sheer amount of published prediction methods - and often discordant reports on their performance - poses a considerable quandary to the experimentalist who needs to choose the best tool for their research. Results: With the goal to provide an unbiased, transparent evaluation of the state-of-the-art in the field, we created an automated platform to benchmark peptide-MHC class II binding prediction tools...
December 21, 2017: Bioinformatics
Tuba Bucak, Dennis Trolle, Ü Nihan Tavşanoğlu, A İdil Çakıroğlu, Arda Özen, Erik Jeppesen, Meryem Beklioğlu
Climate change and intense land use practices are the main threats to ecosystem structure and services of Mediterranean lakes. Therefore, it is essential to predict the future changes and develop mitigation measures to combat such pressures. In this study, Lake Beyşehir, the largest freshwater lake in the Mediterranean basin, was selected to study the impacts of climate change and various land use scenarios on the ecosystem dynamics of Mediterranean freshwater ecosystems and the services that they provide...
April 15, 2018: Science of the Total Environment
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