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https://www.readbyqxmd.com/read/29081790/the-melim-minipig-an-original-spontaneous-model-to-explore-cutaneous-melanoma-genetic-basis
#1
REVIEW
Emmanuelle Bourneuf
Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading to pathology, identify potential biomarkers to be used in the clinics, and eventually molecular targets for therapeutic solutions. Cutaneous melanoma, arising from skin melanocytes, is mainly caused by environmental factors such as UV radiation; however a significant genetic component participates in the etiology of the disease...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29034923/supramolecular-systems-at-liquid-solid-interfaces-general-discussion
#2
David Amabilino, Ioan Bâldea, Pol Besenius, Peter Beton, Matthew Blunt, Manfred Buck, Neil R Champness, Lifeng Chi, Stuart Clarke, Giovanni Costantini, Steven De Feyter, Yuri Diaz Fernandez, Deepak Dwivedi, Karl-Heinz Ernst, Amar Flood, Brandon Hirsch, Robert Jones, Angelika Kühnle, Markus Lackinger, Trolle R Linderoth, Natalia Martsinovich, Andrew Mount, Martin Nalbach, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Marco Sacchi, Sebastian Schwaminger, Steven L Tait, Phil Woodruff, Han Zuilhof
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29034919/supramolecular-effects-in-self-assembled-monolayers-general-discussion
#3
David Amabilino, Ioan Bâldea, James Batteas, Pol Besenius, Peter Beton, Manfred Buck, Lifeng Chi, Giovanni Costantini, Philip Davies, Steven De Feyter, Yuri Diaz Fernandez, Deepak Dwivedi, Karl-Heinz Ernst, Amar Flood, Brandon Hirsch, Vincent Humblot, Robert Jones, Angelika Kühnle, Markus Lackinger, Nian Lin, Trolle R Linderoth, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Marco Sacchi, Sebastian Schwaminger, Steven L Tait, Phil Woodruff, Han Zuilhof
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29034388/probing-properties-of-molecule-based-interface-systems-general-discussion-and-discussion-of-the-concluding-remarks
#4
David Amabilino, Ioan Bâldea, James Batteas, Peter Beton, Nerea Bilbao, Giovanni Costantini, Jonathan Davidson, Steven De Feyter, Yuri Diaz Fernandez, Karl-Heinz Ernst, Brandon Hirsch, Ahmad Jabbarzadeh, Robert Jones, Angelika Kühnle, Markus Lackinger, Zhi Li, Nian Lin, Trolle R Linderoth, Natalia Martsinovich, Martin Nalbach, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Federico Rosei, Marco Sacchi, Mario Samperi, Ana Sanz Matias, Alex Saywell, Sebastian Schwaminger, Steven L Tait
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28994648/smokeless-tobacco-snus-use-and-colorectal-cancer-incidence-and-survival-results-from-nine-pooled-cohorts
#5
Marzieh Araghi, Maria Rosaria Galanti, Michael Lundberg, Zhiwei Liu, Weimin Ye, Anton Lager, Gunnar Engström, Jonas Manjer, Lars Alfredsson, Anders Knutsson, Margareta Norberg, Richard Palmqvist, Björn Gylling, Patrik Wennberg, Ylva Trolle Lagerros, Rino Bellocco, Nancy L Pedersen, Per-Olof Östergren, Cecilia Magnusson
AIMS: Although smoking is considered to be an established risk factor for colorectal cancer, the current evidence on the association between smokeless tobacco and colorectal cancer is scant and inconclusive. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess this association. METHODS: A total of 417,872 male participants from nine cohort studies across Sweden were followed up for incidence of colorectal cancer and death...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28968110/influence-of-ch%C3%A2-%C3%A2-%C3%A2-n-interaction-in-the-self-assembly-of-an-oligo-isoquinolyne-ethynylyne-molecule-with-distinct-conformational-states
#6
Ajiguli Nuermaimaiti, Yanxiao Ning, Jacob L Cramer, Katrine L Svane, Bjørk Hammer, Kurt V Gothelf, Trolle R Linderoth
Molecular conformational flexibility can play an important role in supramolecular self-assembly on surfaces, affecting not least chiral molecular assemblies. To explicitly and systematically investigate the role of molecular conformational flexibility in surface self-assembly, we synthesized a three-bit conformational switch where each of three switching units on the molecules can assume one of two distinct binary positions on the surface. The molecules are designed to promote C-H···N type hydrogen bonds between the switching units...
October 2, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28940092/physical-activity-and-the-risk-of-hip-fracture-in-the-elderly-a-prospective-cohort-study
#7
Ylva Trolle Lagerros, Essi Hantikainen, Karl Michaëlsson, Weimin Ye, Hans-Olov Adami, Rino Bellocco
Physical activity has been inversely associated with the risk of hip fracture, however, few studies have been conducted on the contributions from different domains of physical activity. This study was performed to investigate the association between daily household activities, leisure time physical activity, work-related physical activity and total physical activity during a 24-h period, and the risk of hip fracture. In the Swedish National March Cohort we followed 23,881 men and women aged of 50 and over from 1997 until 2010...
September 22, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28931087/microbial-analysis-of-zetaproteobacteria-and-co-colonizers-of-iron-mats-in-the-troll-wall-vent-field-arctic-mid-ocean-ridge
#8
Jan Vander Roost, Ingunn Hindenes Thorseth, Håkon Dahle
Over the last decade it has become increasingly clear that Zetaproteobacteria are widespread in hydrothermal systems and that they contribute to the biogeochemical cycling of iron in these environments. However, how chemical factors control the distribution of Zetaproteobacteria and their co-occurring taxa remains elusive. Here we analysed iron mats from the Troll Wall Vent Field (TWVF) located at the Arctic Mid-Ocean Ridge (AMOR) in the Norwegian-Greenland Sea. The samples were taken at increasing distances from high-temperature venting chimneys towards areas with ultraslow low-temperature venting, encompassing a large variety in geochemical settings...
2017: PloS One
https://www.readbyqxmd.com/read/28856478/sleep-duration-mortality-and-the-influence-of-age
#9
Torbjörn Åkerstedt, Francesca Ghilotti, Alessandra Grotta, Andrea Bellavia, Ylva Trolle Lagerros, Rino Bellocco
Prior work has shown that both short and long sleep predict mortality. However, sleep duration decreases with age and this may affect the relationship of sleep duration with mortality. The purpose of the present study was to assess whether the association between sleep duration and mortality varies with age. Prospective cohort study. 43,863 individuals (64% women), recruited in September 1997 during the Swedish National March and followed through record-linkages for 13 years. Sleep duration was self-reported and measured using the Karolinska Sleep Questionnaire, and grouped into 4 categories: ≤5, 6, 7 (reference) and ≥8 h...
August 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28813402/the-blogger-and-the-trolls
#10
Emily Temple-Wood
No abstract text is available yet for this article.
August 15, 2017: Scientific American
https://www.readbyqxmd.com/read/28809530/steering-surface-reaction-at-specific-sites-with-self-assembly-strategy
#11
Xiong Zhou, Fabian Bebensee, Mingmei Yang, Regine Bebensee, Fang Cheng, Yang He, Qian Shen, Jian Shang, Zhirong Liu, Flemming Besenbacher, Trolle R Linderoth, Kai Wu
To discern the catalytic activity of different active sites, a self-assembly strategy is applied to confine the involved species that are "attached" to specific surface sites. The employed probe reaction system is the Ullmann coupling of 4-bromobiphenyl, C6H5C6H4Br, on an atomically flat Ag(111) surface, which is explored by combined scanning tunneling microscopy, synchrotron X-ray photoelectron spectroscopy, and density functional theory calculations. The catalytic cycle involves the detachment of the Br atom from the initial reactant to form an organometallic intermediate, C6H5C6H4AgC6H4C6H5, which subsequently self-assembles with its central Ag atom residing either on 2-fold bridge or 3-fold hollow sites at full coverage...
September 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28767515/thirty-five-year-trends-in-first-time-hospitalization-for-hip-fracture-1-year-mortality-and-the-prognostic-impact-of-comorbidity-a-danish-nationwide-cohort-study-1980-2014
#12
Alma B Pedersen, Vera Ehrenstein, Szimonetta K Szépligeti, Astrid Lunde, Ylva Trolle Lagerros, Anna Westerlund, Grethe S Tell, Henrik T Sørensen
BACKGROUND: We examined trends in hip fracture incidence in Denmark from 1980 to 2014, trends in subsequent 1-year mortality, and the prognostic impact of sex, age, and comorbidity. METHODS: This nationwide cohort study prospectively collected data from population-based Danish registries. We included 262,437 patients with incident hip fracture and assessed comorbidity using the Charlson Comorbidity Index (CCI). RESULTS: Despite slight increases in incidence rates (IRs) of hip fracture up to the mid-1990s, the annual IR decreased by 29% from 1980 to 2014 in women but remained stable in men...
November 2017: Epidemiology
https://www.readbyqxmd.com/read/28762721/supramolecular-corrals-on-surfaces-resulting-from-aromatic-interactions-of-nonplanar-triazoles
#13
Siddharth J Jethwa, Esben L Kolsbjerg, Sundar R Vadapoo, Jacob L Cramer, Lutz Lammich, Kurt V Gothelf, Bjørk Hammer, Trolle R Linderoth
Interaction forces between aromatic moieties, often referred to as π-π interactions, are an important element in stabilizing complex supramolecular structures. For supramolecular self-assembly occurring on surfaces, where aromatic moieties are typically forced to adsorb coplanar with the surface, the possible role of intermolecular aromatic interactions is much less explored. Here, we report on unusual, ring-shaped supramolecular corral surface structures resulting from adsorption of a molecule with nonplanar structure, allowing for intermolecular aromatic interactions...
August 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28667869/dynamic-modeling-of-trolling-mode-afm-considering-effects-of-cantilever-torsion-nanoneedle-flexibility-and-liquid-nanoneedle-interactions
#14
Mohammadreza Sajjadi, Hossein Nejat Pishkenari, Gholamreza Vossoughi
Trolling mode atomic force microscope (TR-Mode AFM) significantly reduces the hydrodynamic drag generated during operation in liquid environments. This is achieved by utilizing a long nanoneedle and keeping the cantilever out of liquid. In this research, a continuous mathematical model is developed to study TR-Mode AFM dynamics near a sample submerged in the liquid. Effects of cantilever torsion, nanoneedle flexibility, and liquid-nanoneedle interactions are considered in the model. In order to derive the equations of motion, Hamilton's principle and assumed mode method are used...
June 20, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28662982/extended-oil-spill-spreading-with-langmuir-circulation
#15
Debra Simecek-Beatty, William J Lehr
When spilled in the ocean, most crude oils quickly spread into a thin film that ruptures into smaller slicks distributed over a larger area. Observers have also reported the film tearing apart into streaks that eventually merge forming fewer but longer bands of floating oil. Understanding this process is important to model oil spill transport. First, slick area is calculated using a spreading model. Next, Langmuir circulation models are used to approximate the merging of oiled bands. Calculations are performed on Troll blended and Alaska North Slope crude oils and results compared with measurements from the 1990s North Sea field experiments...
June 26, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28654859/a-comparison-of-methods-to-analyze-aquatic-heterotrophic-flagellates-of-different-taxonomic-groups
#16
Alexandra Jeuck, Frank Nitsche, Claudia Wylezich, Olaf Wirth, Tanja Bergfeld, Fabienne Brutscher, Melanie Hennemann, Shahla Monir, Anja Scherwaß, Nicole Troll, Hartmut Arndt
Heterotrophic flagellates contribute significantly to the matter flux in aquatic and terrestrial ecosystems. Still today their quantification and taxonomic classification bear several problems in field studies, though these methodological problems seem to be increasingly ignored in current ecological studies. Here we describe and test different methods, the live-counting technique, different fixation techniques, cultivation methods like the liquid aliquot method (LAM), and a molecular single cell survey called aliquot PCR (aPCR)...
May 9, 2017: Protist
https://www.readbyqxmd.com/read/28621171/boundary-cap-neural-crest-stem-cell-transplants-contribute-mts1-s100a4-expressing-cells-in-the-glial-scar
#17
Carl Trolle, Patrik Ivert, Jan Hoeber, Iris Rocamonde-Lago, Svitlana Vasylovska, Eugen Lukanidin, Elena N Kozlova
AIM: During development, boundary cap neural crest stem cells (bNCSCs) assist sensory axon growth into the spinal cord. Here we repositioned them to test if they assist regeneration of sensory axons in adult mice after dorsal root avulsion injury. MATERIALS & METHODS: Avulsed mice received bNCSC or human neural progenitor (hNP) cell transplants and their contributions to glial scar formation and sensory axon regeneration were analyzed with immunohistochemistry and transganglionic tracing...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28609621/orchestrating-directional-molecular-motions-kinetically-controlled-supramolecular-pathways-of-a-helical-host-on-rodlike-guests
#18
Xiang Wang, Barbara Wicher, Yann Ferrand, Ivan Huc
An aromatic oligoamide sequence was designed to fold and self-assemble into a double helical host having a cylindrical cavity complementary to linear oligocarbamate guests. Formation of helical pseudorotaxane complexes, foldaxanes, between the host and guests having binding stations of different affinities was evidenced by NMR and X-ray crystallography. Rodlike guests possessing two or three binding stations, long alkyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a single bulky stopper at one end were synthesized...
June 28, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28607762/can-visual-assessment-of-blood-flow-patterns-by-dynamic-contrast-enhanced-computed-tomography-distinguish-between-malignant-and-benign-lung-tumors
#19
Stefan Walbom Harders, Hans Henrik Madsen, Hanne Marie Nellemann, Torben Riis Rasmussen, Jesper Thygesen, Henrik Hager, Niels Trolle Andersen, Finn Rasmussen
BACKGROUND: Dynamic contrast-enhanced computed tomography (DCE-CT) is a tool, which, in theory, can quantify the blood flow and blood volume of tissues. In structured qualitative analysis, parametric color maps yield a visual impression of the blood flow and blood volume within the tissue being studied, allowing for quick identification of the areas with the highest or lowest blood flow and blood volume. PURPOSE: To examine whether DCE-CT could be used to distinguish between malignant and benign lung tumors in patients with suspected lung cancer...
May 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28595290/dietary-fat-intake-and-fecundability-in-two-preconception-cohort-studies
#20
Lauren A Wise, Amelia K Wesselink, Katherine L Tucker, Shilpa Saklani, Ellen M Mikkelsen, Heidi Cueto, Anders H Riis, Ellen Trolle, Craig J McKinnon, Kristen A Hahn, Kenneth J Rothman, Henrik Toft Sørensen, Elizabeth E Hatch
The association between dietary fat and fertility is not well-studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), and omega-3 and-6 fatty acids in relation to fecundability in Danish and North American preconception cohort studies. Female pregnancy planners completed a validated food frequency questionnaire at baseline. Pregnancy status was updated bimonthly for 12 months or until pregnancy. Fecundability ratios (FR) and 95% confidence intervals (CI) were estimated using multivariable proportional probabilities regression...
June 8, 2017: American Journal of Epidemiology
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