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Tuba Bucak, Dennis Trolle, Hans Estrup Andersen, Hans Thodsen, Şeyda Erdoğan, Eti E Levi, Nur Filiz, Erik Jeppesen, Meryem Beklioğlu
Inter- and intra-annual water level fluctuations and changes in water flow regime are intrinsic characteristics of Mediterranean lakes. Additionally, considering climate change projections for the water-limited Mediterranean region, increased air temperatures and decreased precipitation are anticipated, leading to dramatic declines in lake water levels as well as severe water scarcity problems. The study site, Lake Beyşehir, the largest freshwater lake in the Mediterranean basin, is - like other Mediterranean lakes - threatened by climatic changes and over-abstraction of water for irrigated crop farming...
January 6, 2017: Science of the Total Environment
Siddharth J Jethwa, Mikael Madsen, Jakob Back Knudsen, Lutz Lammich, Kurt V Gothelf, Trolle R Linderoth
A phenylene vinylene polymer derivative is deposited onto a Au(111) surface under Ultra-High Vacuum (UHV) conditions using electrospray ionisation deposition and characterised using Scanning Tunnelling Microscopy (STM). High resolution STM images reveal the polymer structure on the monomeric scale, allowing the identification of regioisomerism, the intricate isomerisations of the polymer side-chains, as well as the larger-scale topologies of the polymer strands.
January 5, 2017: Chemical Communications: Chem Comm
Fei Yang, Nancy L Pedersen, Weimin Ye, Zhiwei Liu, Margareta Norberg, Lars Forsgren, Ylva Trolle Lagerros, Rino Bellocco, Lars Alfredsson, Anders Knutsson, Jan-Håkan Jansson, Patrik Wennberg, Maria Rosaria Galanti, Anton C J Lager, Marzieh Araghi, Michael Lundberg, Cecilia Magnusson, Karin Wirdefeldt
BACKGROUND: Cigarette smoking is associated with a lower risk of Parkinson's disease. It is unclear what constituent of tobacco smoke may lower the risk. Use of Swedish moist smokeless tobacco (snus) can serve as a model to disentangle what constituent of tobacco smoke may lower the risk. The aim of this study was to determine whether snus use was associated with a lower risk of Parkinson's disease. METHODS: Individual participant data were collected from seven prospective cohort studies, including 348 601 men...
December 10, 2016: International Journal of Epidemiology
Alastair Thorne, Alisdair I MacDonald, Joseph L Thorley
BACKGROUND: Ferox Trout are large, long-lived piscivorous Brown Trout (Salmo trutta). Due to their exceptionally large size, Ferox Trout are highly sought after by anglers while their life-history strategy, which includes delayed maturation, multiphasic growth and extended longevity, is of interest to ecological and evolutionary modelers. However, despite their recreational and theoretical importance, little is known about the typical abundance of Ferox Trout. METHODS: To rectify this situation a 16 year angling-based mark-recapture study was conducted on Loch Rannoch, which at 19 km(2) is one of the largest lakes in the United Kingdom...
2016: PeerJ
Steffi Burchardt, Valentin R Troll, Harro Schmeling, Hemin Koyi, Lara Blythe
Magmatic stoping is discussed to be a main mechanism of magma emplacement. As a consequence of stoping, abundant country-rock fragments should occur within, and at the bottom of, magma reservoirs as "xenolith graveyards", or become assimilated. However, the common absence of sufficient amounts of both xenoliths and crustal contamination have led to intense controversy about the efficiency of stoping. Here, we present new evidence that may explain the absence of abundant country-rock fragments in plutons. We report on vesiculated crustal xenoliths in volcanic rocks that experienced devolatilisation during heating and partial melting when entrained in magma...
November 2, 2016: Scientific Reports
Robert Cook-Deegan, Saurabh Vishnubhakat, Tania Bubela
No abstract text is available yet for this article.
April 2016: Journal of Law and the Biosciences
Joshua D Sarnoff
This comment on The mouse that trolled by Tania Bubela, Saurabh Vishnubhakat, and Robert Cook-Deegan discusses the authors' description of how patents relating to the gene coding for a protein involved in Alzheimer's disease were obtained and used to sue scientific researchers, of how conflicts can arise among groups of researchers, and of how important research can be delayed or foregone by the exercise of patent rights. The authors sought to counter with evidence the optimistic views that patents on such research tools are not used to sue researchers and thus do not impede sequential innovation...
November 2015: Journal of Law and the Biosciences
John Hardy
No abstract text is available yet for this article.
November 2015: Journal of Law and the Biosciences
Andrew K Cordova, Robin Feldman
Research universities have made enormous contributions to the field of medicine and the treatment of human disease. Alone or in collaboration with pharmaceutical companies, academic researchers have added to the store of knowledge that has led to numerous life science breakthroughs. A new chapter may be opening for academic researchers, however, that could lead to a darker tale. 'The mouse that trolled: the long and tortuous history of a gene mutation patent that became an expensive impediment to Alzheimer's research, by Bubela et al...
November 2015: Journal of Law and the Biosciences
Annika Ries, Rajesh Kumar, Chenguang Lou, Tamer Kosbar, Empar Vengut-Climent, Per T Jørgensen, Juan C Morales, Jesper Wengel
Galactose-modified thymidine, LNA-T, and 2'-amino-LNA-T nucleosides were synthesized, converted into the corresponding phosphoramidite derivatives and introduced into short oligonucleotides. Compared to the unmodified control strands, the galactose-modified oligonucleotides in general, and the N2'-functionalized 2'-amino-LNA derivatives in particular, showed improved duplex thermal stability against DNA and RNA complements and increased ability to discriminate mismatches. In addition, the 2'-amino-LNA-T derivatives induced remarkable 3'-exonuclease resistance...
November 18, 2016: Journal of Organic Chemistry
Ylva Trolle Lagerros
No abstract text is available yet for this article.
October 2016: European Journal of Epidemiology
Harri Geiger, Abigail K Barker, Valentin R Troll
Mt. Cameroon is one of the most active volcanoes in Africa and poses a possible threat to about half a million people in the area, yet knowledge of the volcano's underlying magma supply system is sparse. To characterize Mt. Cameroon's magma plumbing system, we employed mineral-melt equilibrium thermobarometry on the products of the volcano's two most recent eruptions of 1999 and 2000. Our results suggest pre-eruptive magma storage between 20 and 39 km beneath Mt. Cameroon, which corresponds to the Moho level and below...
October 7, 2016: Scientific Reports
Christian Trolle, Morten Muhlig Nielsen, Anne Skakkebæk, Philippe Lamy, Søren Vang, Jakob Hedegaard, Iver Nordentoft, Torben Falck Ørntoft, Jakob Skou Pedersen, Claus Højbjerg Gravholt
Adults with 45,X monosomy (Turner syndrome) reflect a surviving minority since more than 99% of fetuses with 45,X monosomy die in utero. In adulthood 45,X monosomy is associated with increased morbidity and mortality, although strikingly heterogeneous with some individuals left untouched while others suffer from cardiovascular disease, autoimmune disease and infertility. The present study investigates the leukocyte DNAmethylation profile by using the 450K-Illumina Infinium assay and the leukocyte RNA-expression profile in 45,X monosomy compared with karyotypically normal female and male controls...
September 30, 2016: Scientific Reports
Luca Colarusso, Mauro Serafini, Ylva Trolle Lagerros, Olof Nyren, Carlo La Vecchia, Marta Rossi, Weimin Ye, Alessandra Tavani, Hans-Olov Adami, Alessandra Grotta, Rino Bellocco
OBJECTIVE: Both observational studies and randomized trials have shown that a diet rich in antioxidants can reduce systemic inflammation and oxidative stress, two conditions that, together with obesity and smoking, are established risk factors for stroke. However, the association between antioxidant intake and risk for stroke is poorly understood, particularly when studying possible interaction with sex. We investigated the relationship of nonenzymatic antioxidant capacity (NEAC) on risk for stroke in a large Swedish prospective cohort...
January 2017: Nutrition
Ylva Trolle Lagerros, Essi Hantikainen, Daniela Mariosa, Weimin Ye, Hans-Olov Adami, Alessandra Grotta, Francesca Ghilotti, Rino Bellocco
No abstract text is available yet for this article.
September 20, 2016: International Journal of Epidemiology
Jonathan Adam, Stefan Brandmaier, Jörn Leonhardt, Markus F Scheerer, Robert P Mohney, Tao Xu, Jie Bi, Markus Rotter, Martina Troll, Shen Chi, Margit Heier, Christian Herder, Wolfgang Rathmann, Guido Giani, Jerzy Adamski, Thomas Illig, Konstantin Strauch, Yixue Li, Christian Gieger, Annette Peters, Karsten Suhre, Donna Ankerst, Thomas Meitinger, Martin Hrabe de Angelis, Michael Roden, Susanne Neschen, Gabi Kastenmüller, Rui Wang-Sattler
Metformin is the first-line oral medication to increase insulin sensitivity in patients with type 2 diabetes (T2D). Our aim is to investigate metformin's pleiotropic effect using a non-targeted metabolomics approach. We analyzed 353 metabolites in fasting serum samples of the population-based human KORA F4 cohort. To compare T2D patients treated with metformin (mt-T2D, n=74) and those without antidiabetic medication (ndt-T2D, n=115), we used multivariable linear regression models in a cross-sectional study...
September 12, 2016: Diabetes
Morten Herlin, Anne-Mette Bay Bjørn, Maria Rasmussen, Birgitta Trolle, Michael Bjørn Petersen
STUDY QUESTION: What is the prevalence of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome? SUMMARY ANSWER: The prevalence of MRKH syndrome in Denmark is 1 in 4982 (95% confidence interval (CI): 4216-5887) live female births. WHAT IS KNOWN ALREADY: The prevalence of MRKH syndrome has been estimated to be around 1 in 4000-5000 females. However, population-based prevalence studies of MRKH syndrome are sparse. Moreover, population-based data on patient characteristics are lacking...
October 2016: Human Reproduction
Stefan Dietrich, Anna Floegel, Martina Troll, Tilman Kühn, Wolfgang Rathmann, Anette Peters, Disorn Sookthai, Martin von Bergen, Rudolf Kaaks, Jerzy Adamski, Cornelia Prehn, Heiner Boeing, Matthias B Schulze, Thomas Illig, Tobias Pischon, Sven Knüppel, Rui Wang-Sattler, Dagmar Drogan
BACKGROUND: The application of metabolomics in prospective cohort studies is statistically challenging. Given the importance of appropriate statistical methods for selection of disease-associated metabolites in highly correlated complex data, we combined random survival forest (RSF) with an automated backward elimination procedure that addresses such issues. METHODS: Our RSF approach was illustrated with data from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, with concentrations of 127 serum metabolites as exposure variables and time to development of type 2 diabetes mellitus (T2D) as outcome variable...
September 1, 2016: International Journal of Epidemiology
Mette H Viuff, Christian Trolle, Jan Wen, Jesper M Jensen, Bjarne L Nørgaard, Ephraim J Gutmark, Iris Gutmark-Little, Kristian H Mortensen, Claus Højbjerg Gravholt, Niels H Andersen
BACKGROUND: Congenital heart disease, primarily involving the left-sided structures, is often seen in patients with Turner Syndrome. Moreover, a few case reports have indicated that coronary anomalies may be more prevalent in Turner Syndrome than in the normal population. We therefore set out to systematically investigate coronary arterial anatomy by computed tomographic coronary angiography (coronary CTA) in Turner Syndrome patients. METHODS: Fifty consecutive women with Turner Syndrome (mean age 47 years [17-71]) underwent coronary CTA...
November 2016: Journal of Cardiovascular Computed Tomography
Ala'a F Eftaiha, Fatima Alsoubani, Khaleel I Assaf, Carsten Troll, Bernhard Rieger, Aseel H Khaled, Abdussalam K Qaroush
Chitin is considered to be the second most abundant naturally-occurring polysaccharide. Also, dimethyl sulfoxide (DMSO) is the second highest dielectric constant polar solvent after water. Despite the low solubility of chitin in common organic solvents, and due to its high nitrogen content, it may serve as a potential scrubbing agent "wet scrubbing" for carbon dioxide (CO2) capturing as an alternative to monoethanolamine "renewables for renewables approach". Briefly, a detailed investigation for the utilization of low molecular weight, chitin-acetate (CA) in DMSO for the capturing of CO2 is reported...
November 5, 2016: Carbohydrate Polymers
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