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https://www.readbyqxmd.com/read/28280146/association-between-treatment-for-erectile-dysfunction-and-death-or-cardiovascular-outcomes-after-myocardial-infarction
#1
Daniel P Andersson, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J Holzmann
OBJECTIVE: Erectile dysfunction (ED) is associated with an increased risk of cardiovascular disease in healthy men. However, the association between treatment for ED and death or cardiovascular outcomes after a first myocardial infarction (MI) is unknown. METHODS: In a Swedish nationwide cohort study all men <80 years of age without prior MI, or cardiac revascularisation, hospitalised for MI during 2007-2013 were included. Treatment for ED, defined as dispensed phosphodiesterase-5 inhibitors or alprostadil, was related to risk of death, MI, cardiac revascularisation or heart failure...
March 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28260207/biochemical-assessment-of-disease-control-in-acromegaly-reappraisal-of-the-glucose-suppression-test-in-somatostatin-analogue-sa-treated-patients
#2
Mai Christiansen Arlien-Søborg, Christian Trolle, Elin Alvarson, Amanda Bæk, Jakob Dal, Jens Otto Lunde Jørgensen
BACKGROUND: It is recommended not to measure growth hormone during oral glucose suppression (oral glucose tolerance test) during somatostatin analog treatment in acromegaly. However, we have observed that failure to suppress growth hormone in response to oral glucose tolerance test during somatostatin analog unmasks insufficient disease control and hypothesize that somatostatin analog also induces insufficient growth hormone suppression to mixed meals. METHODS: We therefore compared serum growth hormone levels during two mixed meals in patients with controlled insulin-like growth factor-I levels after either surgery alone (n = 9) or somatostatin analog treatment (n = 9)...
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28238147/returning-to-the-patent-landscapes-for-nanotechnology-assessing-the-garden-that-it-has-grown-into
#3
Diana M Bowman, Douglas J Sylvester, Anthony D Marino
The patent landscape, like a garden, can tell you much about its designers and users; their motivations, biases, and general interests. While both patent landscapes and gardens may appear to the casual observer as refined and ordered, an in-depth exploration of the terrain is likely to reveal unforeseen challenges including, for example, alien species, thickets, and trolls. As this Chapter illustrates, patent landscapes are dynamic and have been forced to continually evolve in response to technological innovation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28231421/varying-demographic-impacts-of-different-fisheries-on-three-mediterranean-seabird-species
#4
M Genovart, D Doak, J M Igual, S Sponza, J Kralj, D Oro
Fisheries have an enormous economic importance but reconciling their socio-economic features with the conservation and sustainability of marine ecosystems presents major challenges. Bycatch mortality from fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide range of top predators. Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters. However there is an urgent need to rigorously estimate actual mortality rates and quantify effects of bycatch on populations...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28220306/long-term-results-using-ligasure%C3%A2-5%C3%A2-mm-instrument-for-treatment-of-zenker-s-diverticulum
#5
Michelle Fog Andersen, Waldemar Trolle, Kristian Anthonsen, Hans Ulrik Nielsen, Preben Homøe
The purpose of the present study was to evaluate the long-term results and patient's satisfaction of a new approach using the LigaSure™ 5 mm instrument for treatment of Zenker's diverticulum (ZD) and to compare with other long-term results using traditional treatment modalities. Between December 2011 and August 2013, a total of 23 patients with ZD underwent endoscopic surgery using the LigaSure™ technique in our department. A retrospective evaluation of the surgery was based on medical records and additionally a long-term follow-up was performed using a standardized questionnaire that was send to all patients...
April 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28207737/the-enteric-nervous-system-promotes-intestinal-health-by-constraining-microbiota-composition
#6
Annah S Rolig, Erika K Mittge, Julia Ganz, Josh V Troll, Ellie Melancon, Travis J Wiles, Kristin Alligood, W Zac Stephens, Judith S Eisen, Karen Guillemin
Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition. We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts...
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/28174642/prolonged-qt-interval-and-cardiac-arrest-after-a-single-dose-of-amiodarone-in-a-woman-with-turner-s-syndrome
#7
Dorte Guldbrand Nielsen, Jens Cosedis Nielsen, Christian Trolle, Claus Højbjerg Gravholt, Niels Holmark Andersen
Low-dose QT-prolonging drugs may have detrimental effects on women with Turner's syndrome. Preventive measures would be to use potential QT-prolonging drugs with precaution and ensure that both before and during treatment, ECGs are evaluated and drug treatment stopped if the QT interval increases.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28164394/smokeless-tobacco-snus-is-associated-with-an-increased-risk-of-type-2-diabetes-results-from-five-pooled-cohorts
#8
S Carlsson, T Andersson, M Araghi, R Galanti, A Lager, M Lundberg, P Nilsson, M Norberg, N L Pedersen, Y Trolle-Lagerros, C Magnusson
BACKGROUND: Smoking and nicotine exposure increase insulin resistance and the risk of type 2 diabetes. Swedish smokeless tobacco (snus) is high in nicotine, and its use is prevalent in Scandinavian countries, but few studies have investigated snus use in relation to diabetes risk. OBJECTIVE: To explore the association between snus use and risk of type 2 diabetes using pooled data from five cohorts. METHODS: Analyses were based on prospective studies conducted between 1990 and 2013 including 54 531 never-smoking men and 2441 incident cases of type 2 diabetes identified through screening, self-reporting and hospital and prescription registries...
February 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28150905/development-of-an-efficient-g-quadruplex-stabilized-thrombin-binding-aptamer-containing-3-carbon-spacer-molecule
#9
Rakesh Naduvile Veedu, Lukas Aaldering, Vasanthanathan Poongavanam, Niels Langkjaer, Arul Murugan, Per Trolle Jørgensen, Jesper Wengel
Thrombin binding aptamer (TBA) that shows anticoagulant properties is one of the most studied G-quadruplex forming aptamers. In this study, we investigated the impact of different chemical modifications such as Spacer-C3, unlocked nucleic acid (UNA) and 3'-amine-modified UNA (amino-UNA) on the structural dynamics and stability of TBA. All three modifications were incorporated at three different loop positions (T3, T7 and T12) of the TBA G-quadruplex structure rendering a series of TBA variants and studied their stability by thermal denaturation studies, folding by circular dichroism spectroscopy and thrombin clotting time...
February 2, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28120860/magma-reservoir-dynamics-at-toba-caldera-indonesia-recorded-by-oxygen-isotope-zoning-in-quartz
#10
David A Budd, Valentin R Troll, Frances M Deegan, Ester M Jolis, Victoria C Smith, Martin J Whitehouse, Chris Harris, Carmela Freda, David R Hilton, Sæmundur A Halldórsson, Ilya N Bindeman
Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ(18)O values. Overall, Toba quartz crystals exhibit comparatively high δ(18)O values, up to 10.2‰, due to magma residence within, and assimilation of, local granite basement. However, some 40% of the analysed quartz crystals display a decrease in δ(18)O values in outermost growth zones compared to their cores, with values as low as 6...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28117326/model-dielectric-function-for-2d-semiconductors-including-substrate-screening
#11
Mads L Trolle, Thomas G Pedersen, Valerie Véniard
Dielectric screening of excitons in 2D semiconductors is known to be a highly non-local effect, which in reciprocal space translates to a strong dependence on momentum transfer q. We present an analytical model dielectric function, including the full non-linear q-dependency, which may be used as an alternative to more numerically taxing ab initio screening functions. By verifying the good agreement between excitonic optical properties calculated using our model dielectric function, and those derived from ab initio methods, we demonstrate the versatility of this approach...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069301/future-water-availability-in-the-largest-freshwater-mediterranean-lake-is-at-great-risk-as-evidenced-from-simulations-with-the-swat-model
#12
Tuba Bucak, Dennis Trolle, Hans Estrup Andersen, Hans Thodsen, Şeyda Erdoğan, Eti E Levi, Nur Filiz, Erik Jeppesen, Meryem Beklioğlu
Inter- and intra-annual water level fluctuations and changes in water flow regime are intrinsic characteristics of Mediterranean lakes. Additionally, considering climate change projections for the water-limited Mediterranean region, increased air temperatures and decreased precipitation are anticipated, leading to dramatic declines in lake water levels as well as severe water scarcity problems. The study site, Lake Beyşehir, the largest freshwater lake in the Mediterranean basin, is - like other Mediterranean lakes - threatened by climatic changes and over-abstraction of water for irrigated crop farming...
January 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28054080/revealing-the-structural-detail-of-individual-polymers-using-a-combination-of-electrospray-deposition-and-uhv-stm
#13
Siddharth J Jethwa, Mikael Madsen, Jakob Back Knudsen, Lutz Lammich, Kurt V Gothelf, Trolle R Linderoth
A phenylene vinylene polymer derivative is deposited onto a Au(111) surface under Ultra-High Vacuum (UHV) conditions using electrospray ionisation deposition and characterised using Scanning Tunnelling Microscopy (STM). High resolution STM images reveal the polymer structure on the monomeric scale, allowing the identification of regioisomerism, the intricate isomerisations of the polymer side-chains, as well as the larger-scale topologies of the polymer strands.
January 5, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27940486/moist-smokeless-tobacco-snus-use-and-risk-of-parkinson-s-disease
#14
Fei Yang, Nancy L Pedersen, Weimin Ye, Zhiwei Liu, Margareta Norberg, Lars Forsgren, Ylva Trolle Lagerros, Rino Bellocco, Lars Alfredsson, Anders Knutsson, Jan-Håkan Jansson, Patrik Wennberg, Maria Rosaria Galanti, Anton C J Lager, Marzieh Araghi, Michael Lundberg, Cecilia Magnusson, Karin Wirdefeldt
BACKGROUND: Cigarette smoking is associated with a lower risk of Parkinson's disease. It is unclear what constituent of tobacco smoke may lower the risk. Use of Swedish moist smokeless tobacco (snus) can serve as a model to disentangle what constituent of tobacco smoke may lower the risk. The aim of this study was to determine whether snus use was associated with a lower risk of Parkinson's disease. METHODS: Individual participant data were collected from seven prospective cohort studies, including 348 601 men...
December 10, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27833812/the-abundance-of-large-piscivorous-ferox-trout-salmo-trutta-in-loch-rannoch-scotland
#15
Alastair Thorne, Alisdair I MacDonald, Joseph L Thorley
BACKGROUND: Ferox Trout are large, long-lived piscivorous Brown Trout (Salmo trutta). Due to their exceptionally large size, Ferox Trout are highly sought after by anglers while their life-history strategy, which includes delayed maturation, multiphasic growth and extended longevity, is of interest to ecological and evolutionary modelers. However, despite their recreational and theoretical importance, little is known about the typical abundance of Ferox Trout. METHODS: To rectify this situation a 16 year angling-based mark-recapture study was conducted on Loch Rannoch, which at 19 km(2) is one of the largest lakes in the United Kingdom...
2016: PeerJ
https://www.readbyqxmd.com/read/27804996/erupted-frothy-xenoliths-may-explain-lack-of-country-rock-fragments-in-plutons
#16
Steffi Burchardt, Valentin R Troll, Harro Schmeling, Hemin Koyi, Lara Blythe
Magmatic stoping is discussed to be a main mechanism of magma emplacement. As a consequence of stoping, abundant country-rock fragments should occur within, and at the bottom of, magma reservoirs as "xenolith graveyards", or become assimilated. However, the common absence of sufficient amounts of both xenoliths and crustal contamination have led to intense controversy about the efficiency of stoping. Here, we present new evidence that may explain the absence of abundant country-rock fragments in plutons. We report on vesiculated crustal xenoliths in volcanic rocks that experienced devolatilisation during heating and partial melting when entrained in magma...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774240/the-mouse-that-trolled-again
#17
Robert Cook-Deegan, Saurabh Vishnubhakat, Tania Bubela
No abstract text is available yet for this article.
April 2016: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27774223/the-patent-law-duchy-of-grand-fenwick-a-comment-on-the-mouse-that-trolled-the-long-and-tortuous-history-of-a-gene-mutation-patent-that-became-an-expensive-impediment-to-alzheimer-s-research
#18
Joshua D Sarnoff
This comment on The mouse that trolled by Tania Bubela, Saurabh Vishnubhakat, and Robert Cook-Deegan discusses the authors' description of how patents relating to the gene coding for a protein involved in Alzheimer's disease were obtained and used to sue scientific researchers, of how conflicts can arise among groups of researchers, and of how important research can be delayed or foregone by the exercise of patent rights. The authors sought to counter with evidence the optimistic views that patents on such research tools are not used to sue researchers and thus do not impede sequential innovation...
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27774222/the-mouse-that-trolled
#19
John Hardy
No abstract text is available yet for this article.
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27774221/universities-and-patent-demands
#20
Andrew K Cordova, Robin Feldman
Research universities have made enormous contributions to the field of medicine and the treatment of human disease. Alone or in collaboration with pharmaceutical companies, academic researchers have added to the store of knowledge that has led to numerous life science breakthroughs. A new chapter may be opening for academic researchers, however, that could lead to a darker tale. 'The mouse that trolled: the long and tortuous history of a gene mutation patent that became an expensive impediment to Alzheimer's research, by Bubela et al...
November 2015: Journal of Law and the Biosciences
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