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https://www.readbyqxmd.com/read/28621171/boundary-cap-neural-crest-stem-cell-transplants-contribute-mts1-s100a4-expressing-cells-in-the-glial-scar
#1
Carl Trolle, Patrik Ivert, Jan Hoeber, Iris Rocamonde-Lago, Svitlana Vasylovska, Eugen Lukanidin, Elena N Kozlova
AIM: During development, boundary cap neural crest stem cells (bNCSCs) assist sensory axon growth into the spinal cord. Here we repositioned them to test if they assist regeneration of sensory axons in adult mice after dorsal root avulsion injury. MATERIALS & METHODS: Avulsed mice received bNCSC or human neural progenitor (hNP) cell transplants and their contributions to glial scar formation and sensory axon regeneration were analyzed with immunohistochemistry and transganglionic tracing...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28609621/orchestrating-directional-molecular-motions-kinetically-con-trolled-supramolecular-pathways-of-a-helical-host-on-rod-like-guests
#2
Xiang Wang, Barbara Wicher, Yann Ferrand, Ivan Huc
An aromatic oligoamide sequence was designed to fold and self-assemble into a double helical host having a cylindrical cavity complementary to linear oligo-carbamates guests. Formation of helical pseudo-rotaxane complexes - foldaxanes - between the host and guests having binding stations of different affinities was evidenced by NMR and x-ray crystallog-raphy. Rod-like guests possessing two or three binding stations, long alkyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a single bulky stopper at one end, were synthesized...
June 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28607762/can-visual-assessment-of-blood-flow-patterns-by-dynamic-contrast-enhanced-computed-tomography-distinguish-between-malignant-and-benign-lung-tumors
#3
Stefan Walbom Harders, Hans Henrik Madsen, Hanne Marie Nellemann, Torben Riis Rasmussen, Jesper Thygesen, Henrik Hager, Niels Trolle Andersen, Finn Rasmussen
BACKGROUND: Dynamic contrast-enhanced computed tomography (DCE-CT) is a tool, which, in theory, can quantify the blood flow and blood volume of tissues. In structured qualitative analysis, parametric color maps yield a visual impression of the blood flow and blood volume within the tissue being studied, allowing for quick identification of the areas with the highest or lowest blood flow and blood volume. PURPOSE: To examine whether DCE-CT could be used to distinguish between malignant and benign lung tumors in patients with suspected lung cancer...
May 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28595290/dietary-fat-intake-and-fecundability-in-two-preconception-cohort-studies
#4
Lauren A Wise, Amelia K Wesselink, Katherine L Tucker, Shilpa Saklani, Ellen M Mikkelsen, Heidi Cueto, Anders H Riis, Ellen Trolle, Craig J McKinnon, Kristen A Hahn, Kenneth J Rothman, Henrik Toft Sørensen, Elizabeth E Hatch
The association between dietary fat and fertility is not well-studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), and omega-3 and-6 fatty acids in relation to fecundability in Danish and North American preconception cohort studies. Female pregnancy planners completed a validated food frequency questionnaire at baseline. Pregnancy status was updated bimonthly for 12 months or until pregnancy. Fecundability ratios (FR) and 95% confidence intervals (CI) were estimated using multivariable proportional probabilities regression...
June 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28574299/quality-indicators-for-the-diagnosis-and-antibiotic-treatment-of-acute-respiratory-tract-infections-in-general-practice-a-rand-appropriateness-method
#5
Laura Trolle Saust, Lars Bjerrum, Magnus Arpi, Malene Plejdrup Hansen
OBJECTIVE: To develop quality indicators for the diagnosis and antibiotic treatment of acute respiratory tract infections, tailored to the Danish general practice setting. DESIGN: A RAND/UCLA Appropriateness Method was used. SETTING: General practice. SUBJECTS: A panel of nine experts, mainly general practitioners, was asked to rate the relevance of 64 quality indicators for the diagnosis and antibiotic treatment of acute respiratory tract infections based on guidelines...
June 2, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28562227/a-combinatorial-approach-to-induce-sensory-axon-regeneration-into-the-dorsal-root-avulsed-spinal-cord
#6
Jan Hoeber, Niclas König, Carl Trolle, Emilia Lekholm, Chunfang Zhou, Stanislava Pankratova, Elisabet Åkesson, Robert Fredriksson, Håkan Aldskogius, Elena N Kozlova
Spinal root injuries result in newly formed glial scar formation, which prevents regeneration of sensory axons causing permanent sensory loss. Previous studies showed that delivery of trophic factors or implantation of human neural progenitor cells supports sensory axon regeneration and partly restores sensory functions. In this study, we elucidate mechanisms underlying stem cell-mediated ingrowth of sensory axons after dorsal root avulsion (DRA). We show that human spinal cord neural stem/progenitor cells (hscNSPC), and also, mesoporous silica particles loaded with growth factor mimetics (MesoMIM), supported sensory axon regeneration...
May 31, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28526836/characterisation-of-antibiotic-prescriptions-for-acute-respiratory-tract-infections-in-danish-general-practice-a-retrospective-registry-based-cohort-study
#7
Rune Aabenhus, Malene Plejdrup Hansen, Laura Trolle Saust, Lars Bjerrum
Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendations are followed. We aimed to characterise the pattern of antibiotic prescriptions for patients diagnosed with acute respiratory tract infections, by means of electronic prescriptions, labeled with clinical indications, from Danish general practice...
May 19, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28497960/using-dynamic-covalent-chemistry-to-drive-morphological-transitions-controlled-release-of-encapsulated-nanoparticles-from-block-copolymer-vesicles
#8
Renhua Deng, Matthew J Derry, Charlotte J Mable, Yin Ning, Steven P Armes
Dynamic covalent chemistry is exploited to drive morphological order-order transitions to achieve the controlled release of a model payload (e.g., silica nanoparticles) encapsulated within block copolymer vesicles. More specifically, poly(glycerol monomethacrylate)-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) diblock copolymer vesicles were prepared via aqueous polymerization-induced self-assembly in either the presence or absence of silica nanoparticles. Addition of 3-aminophenylboronic acid (APBA) to such vesicles results in specific binding of this reagent to some of the pendent cis-diol groups on the hydrophilic PGMA chains to form phenylboronate ester bonds in mildly alkaline aqueous solution (pH ∼ 10)...
June 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28486772/use-of-moist-oral-snuff-snus-and-pancreatic-cancer-pooled-analysis-of-nine-prospective-observational-studies
#9
Marzieh Araghi, Maria Rosaria Galanti, Michael Lundberg, Anton Lager, Gunnar Engström, Lars Alfredsson, Anders Knutsson, Margareta Norberg, Malin Sund, Patrik Wennberg, Ylva Trolle Lagerros, Rino Bellocco, Nancy L Pedersen, Per-Olof Östergren, Cecilia Magnusson
While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors...
May 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28446496/mobile-based-intervention-intended-to-stop-obesity-in-preschool-aged-children-the-ministop-randomized-controlled-trial
#10
Christine Delisle Nyström, Sven Sandin, Pontus Henriksson, Hanna Henriksson, Ylva Trolle-Lagerros, Christel Larsson, Ralph Maddison, Francisco B Ortega, Jeremy Pomeroy, Jonatan R Ruiz, Kristin Silfvernagel, Toomas Timpka, Marie Löf
Background: Traditional obesity prevention programs are time- and cost-intensive. Mobile phone technology has been successful in changing behaviors and managing weight; however, to our knowledge, its potential in young children has yet to be examined.Objective: We assessed the effectiveness of a mobile health (mHealth) obesity prevention program on body fat, dietary habits, and physical activity in healthy Swedish children aged 4.5 y.Design: From 2014 to 2015, 315 children were randomly assigned to an intervention or control group...
April 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28397673/-tracheotomy
#11
Marianne Kromann Nielsen, Erik Gustav Hägerström, Waldemar Trolle
The number of tracheotomies in Denmark has roughly tripled over the past 15 years. During this period, percutaneous dilatational tracheotomy has become still more common because of its easier accessibility, and it accounted for 66% of all tracheotomies in 2015 vs. 9% in 2000. However, due to the risk of fatal complications the method is only applicable when anatomical and medical conditions are favourable. Surgical tracheotomy is a safer method in some patients, and it is preferred if the patient has had a tracheostomy previously or presents with a difficult anatomy, coagulopathy or previous neck irradiation...
February 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28392715/positive-predictive-values-of-international-classification-of-diseases-10th-revision-codes-for-dermatologic-events-and-hypersensitivity-leading-to-hospitalization-or-emergency-room-visit-among-women-with-postmenopausal-osteoporosis-in-the-danish-and-swedish
#12
Kasper Adelborg, Lotte Brix Christensen, Troels Munch, Johnny Kahlert, Ylva Trolle Lagerros, Grethe S Tell, Ellen M Apalset, Fei Xue, Vera Ehrenstein
BACKGROUND: Clinical epidemiology research studies, including pharmacoepidemiology and pharmacovigilance studies, use routinely collected health data, such as diagnoses recorded in national health and administrative registries, to assess clinical effectiveness and safety of treatments. We estimated positive predictive values (PPVs) of International Classification of Diseases, 10th revision (ICD-10) codes for primary diagnoses of dermatologic events and hypersensitivity recorded at hospitalization or emergency room visit in the national patient registries of Denmark and Sweden among women with postmenopausal osteoporosis (PMO)...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28359276/perceived-stress-among-20-21-year-olds-and-their-future-labour-market-participation-an-eight-year-follow-up-study
#13
Nanna Trolle, Thomas Lund, Trine Nohr Winding, Merete Labriola
BACKGROUND: Labour market participation among young adults is essential for their future socioeconomic status and health. The aim of this study was to investigate the association between perceived stress among 20-21 year-olds and their labour market participation 8 years later as well as investigate any potential gender differences. METHODS: A cohort of 1640 young adults born in 1983 completed a questionnaire in 2004 in which perceived stress was measured. The cohort was followed in a register of social benefits for 12 months in 2011-2012 and was categorized into active and passive labour market participation...
March 31, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28280146/association-between-treatment-for-erectile-dysfunction-and-death-or-cardiovascular-outcomes-after-myocardial-infarction
#14
Daniel P Andersson, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J Holzmann
OBJECTIVE: Erectile dysfunction (ED) is associated with an increased risk of cardiovascular disease in healthy men. However, the association between treatment for ED and death or cardiovascular outcomes after a first myocardial infarction (MI) is unknown. METHODS: In a Swedish nationwide cohort study all men <80 years of age without prior MI, or cardiac revascularisation, hospitalised for MI during 2007-2013 were included. Treatment for ED, defined as dispensed phosphodiesterase-5 inhibitors or alprostadil, was related to risk of death, MI, cardiac revascularisation or heart failure...
March 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28260207/biochemical-assessment-of-disease-control-in-acromegaly-reappraisal-of-the-glucose-suppression-test-in-somatostatin-analogue-sa-treated-patients
#15
Mai Christiansen Arlien-Søborg, Christian Trolle, Elin Alvarson, Amanda Bæk, Jakob Dal, Jens Otto Lunde Jørgensen
BACKGROUND: It is recommended not to measure growth hormone during oral glucose suppression (oral glucose tolerance test) during somatostatin analog treatment in acromegaly. However, we have observed that failure to suppress growth hormone in response to oral glucose tolerance test during somatostatin analog unmasks insufficient disease control and hypothesize that somatostatin analog also induces insufficient growth hormone suppression to mixed meals. METHODS: We therefore compared serum growth hormone levels during two mixed meals in patients with controlled insulin-like growth factor-I levels after either surgery alone (n = 9) or somatostatin analog treatment (n = 9)...
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28238147/returning-to-the-patent-landscapes-for-nanotechnology-assessing-the-garden-that-it-has-grown-into
#16
Diana M Bowman, Douglas J Sylvester, Anthony D Marino
The patent landscape, like a garden, can tell you much about its designers and users; their motivations, biases, and general interests. While both patent landscapes and gardens may appear to the casual observer as refined and ordered, an in-depth exploration of the terrain is likely to reveal unforeseen challenges including, for example, alien species, thickets, and trolls. As this Chapter illustrates, patent landscapes are dynamic and have been forced to continually evolve in response to technological innovation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28231421/varying-demographic-impacts-of-different-fisheries-on-three-mediterranean-seabird-species
#17
Meritxell Genovart, Daniel F Doak, José-Manuel Igual, Stefano Sponza, Jelena Kralj, Daniel Oro
Fisheries have an enormous economic importance, but reconciling their socio-economic features with the conservation and sustainability of marine ecosystems presents major challenges. Bycatch mortality from fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide range of top predators. Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters. However, there is an urgent need to rigorously estimate actual mortality rates and quantify effects of bycatch on populations...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28220306/long-term-results-using-ligasure%C3%A2-5%C3%A2-mm-instrument-for-treatment-of-zenker-s-diverticulum
#18
Michelle Fog Andersen, Waldemar Trolle, Kristian Anthonsen, Hans Ulrik Nielsen, Preben Homøe
The purpose of the present study was to evaluate the long-term results and patient's satisfaction of a new approach using the LigaSure™ 5 mm instrument for treatment of Zenker's diverticulum (ZD) and to compare with other long-term results using traditional treatment modalities. Between December 2011 and August 2013, a total of 23 patients with ZD underwent endoscopic surgery using the LigaSure™ technique in our department. A retrospective evaluation of the surgery was based on medical records and additionally a long-term follow-up was performed using a standardized questionnaire that was send to all patients...
April 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28207737/the-enteric-nervous-system-promotes-intestinal-health-by-constraining-microbiota-composition
#19
Annah S Rolig, Erika K Mittge, Julia Ganz, Josh V Troll, Ellie Melancon, Travis J Wiles, Kristin Alligood, W Zac Stephens, Judith S Eisen, Karen Guillemin
Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition. We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts...
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/28174642/prolonged-qt-interval-and-cardiac-arrest-after-a-single-dose-of-amiodarone-in-a-woman-with-turner-s-syndrome
#20
Dorte Guldbrand Nielsen, Jens Cosedis Nielsen, Christian Trolle, Claus Højbjerg Gravholt, Niels Holmark Andersen
Low-dose QT-prolonging drugs may have detrimental effects on women with Turner's syndrome. Preventive measures would be to use potential QT-prolonging drugs with precaution and ensure that both before and during treatment, ECGs are evaluated and drug treatment stopped if the QT interval increases.
February 2017: Clinical Case Reports
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