Read by QxMD icon Read


Sten O Nilsson Lill, Cory M Widdifield, Anna Pettersen, Anna Svensk Ankarberg, Maria Lindkvist, Peter Aldred, Sandra Gracin, Norman Shankland, Kenneth Shankland, Staffan Schantz, Lyndon Emsley
By the combined use of powder and single crystal X-ray diffraction, solid-state NMR, and molecular modelling, the crystal structures of two systems containing the unusually large tenapanor drug molecule have been determined: the free form, ANHY and a dihydrochloride salt form, 2HCl. Dynamic nuclear polarization (DNP) assisted solid-state NMR (SSNMR) crystallography investigations were found essential for the final assignment, and were used to validate the crystal structure of ANHY. From the structural informatics analysis of ANHY and 2HCl, conformational ring differences in one part of the molecule were observed which influences the relative orientation of a methyl group on a ring nitrogen and thereby impacts the crystallizability of the dihydrochloride salt...
February 28, 2018: Molecular Pharmaceutics
Joshua V Troll, M Kristina Hamilton, Melissa L Abel, Julia Ganz, Jennifer M Bates, W Zac Stephens, Ellie Melancon, Michiel van der Vaart, Annemarie H Meijer, Martin Distel, Judith S Eisen, Karen Guillemin
Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein...
February 23, 2018: Development
Emma Christine Jappe, Jens Kringelum, Thomas Trolle, Morten Nielsen
Peptides that bind to and are presented by MHC class I and class II molecules collectively make up the immunopeptidome. In the context of vaccine development, an understanding of the immunopeptidome is essential, and much effort has been dedicated to its accurate and cost-effective identification. Current state-of-the-art methods mainly comprise in silico tools for predicting MHC binding which is strongly correlated with peptide immunogenicity. However, only a small proportion of the peptides that bind to MHC molecules are, in fact, immunogenic, and substantial work has been dedicated to uncovering additional determinants of peptide immunogenicity...
February 15, 2018: Immunology
Yongjun Men, Wei Li, Geert-Jan A Janssen, Roger S M Rikken, Daniela A Wilson
Accurate control of the shape transformation of polymersome is an important and interesting challenge that spans across disciplines such as nanomedicine and nanomachine. Here we report a fast and facile methodology of shape manipulation of polymersome via out-of-equilibrium polymer self-assembly and shape change by chemical addition of additives. Due to its increased permeability, hydrophilicity and fusogenic properties, poly(ethylene oxide) (PEG) was selected as the additive for bringing the system out of equilibrium via fast addition into the polymersome organic solution...
February 7, 2018: Nano Letters
Essi Hantikainen, Marie Löf, Alessandra Grotta, Ylva Trolle Lagerros, Mauro Serafini, Rino Bellocco, Elisabete Weiderpass
Foods rich in antioxidants have been associated with a reduced risk of myocardial infarction. However, findings from randomized clinical trials on the role of antioxidant supplementation remain controversial. It has been suggested that antioxidants interact with each other to promote cardiovascular health. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), measuring the total antioxidant potential of the whole diet, and the risk of myocardial infarction. We followed 45,882 women aged 30-49 years and free from cardiovascular diseases through record linkages from 1991 until 2012...
January 25, 2018: European Journal of Epidemiology
Christian Trolle, Sanne Fisker
No abstract text is available yet for this article.
January 22, 2018: Ugeskrift for Laeger
Taehoon H Kim, Young Ki Hahn, Jungmin Lee, Danny van Noort, Minseok S Kim
As paper-based diagnostics has become predominantly driven by more advanced microfluidic technology, many of the research efforts are still focused on developing reliable and versatile fluidic control devices, apart from improving sensitiv-ity and reproducibility. In this paper, we introduce a novel and robust paper fluidic control system enabling versatile flu-idic control. The system comprises a linear push-pull solenoid and an Arduino Uno microcontroller. The precisely con-trolled pressure exerted on the paper stops the flow...
January 24, 2018: Analytical Chemistry
Tove Lise Nielsen, Niels Trolle Andersen, Kirsten Schultz Petersen, Helene Polatajko, Claus Vinther Nielsen
BACKGROUND: There is growing interest in enabling older adults' occupational performance. We tested whether 11 weeks of intensive client-centred occupational therapy (ICC-OT) was superior to usual practice in improving the occupational performance of home-dwelling older adults. METHODS: An assessor-masked randomized controlled trial among adults 60 + with chronic health issues, who received or applied for homecare services. Recruitment took place September 2012 to April 2014...
January 12, 2018: Scandinavian Journal of Occupational Therapy
Stephanie E Bonn, Christina Alexandrou, Kristin Hjörleifsdottir Steiner, Klara Wiklander, Claes-Göran Östenson, Marie Löf, Ylva Trolle Lagerros
BACKGROUND: Physical activity can decrease the risk of complications related to diabetes type 2. Feasible and scalable strategies to implement support for a healthy lifestyle for patients in primary care are needed. The aim of the DiaCert-study is to evaluate a digital healthcare platform and the effect of a 12-week long smartphone-app physical activity intervention aiming at increasing physical activity (primary outcome) and improve levels of HbA1c (glycated hemoglobin), blood lipids, blood pressure, body composition, as well as other lifestyle factors and overall health in patients with diabetes type 2...
January 10, 2018: BMC Public Health
Francesca Ghilotti, Ann-Sofie Pesonen, Sara E Raposo, Henric Winell, Olof Nyrén, Ylva Trolle Lagerros, Amelie Plymoth
OBJECTIVES: Previous studies found higher levels of physical activity to be protective against infections and that short and long sleep negatively affects the immune response. However, these relationships remain debatable. We aimed to investigate if physical activity and sleep habits affect incidence of upper respiratory tract infections (URTI) in a prospective cohort study. METHODS: A total of 2,038 adults aged 25-64 years served as a random sample of the gainfully employed population of an industrial town in Sweden...
2018: PloS One
Massimo Andreatta, Thomas Trolle, Zhen Yan, Jason A Greenbaum, Bjoern Peters, Morten Nielsen
Motivation: Computational methods for the prediction of peptide-MHC binding have become an integral and essential component for candidate selection in experimental T cell epitope discovery studies. The sheer amount of published prediction methods - and often discordant reports on their performance - poses a considerable quandary to the experimentalist who needs to choose the best tool for their research. Results: With the goal to provide an unbiased, transparent evaluation of the state-of-the-art in the field, we created an automated platform to benchmark peptide-MHC class II binding prediction tools...
December 21, 2017: Bioinformatics
Tuba Bucak, Dennis Trolle, Ü Nihan Tavşanoğlu, A İdil Çakıroğlu, Arda Özen, Erik Jeppesen, Meryem Beklioğlu
Climate change and intense land use practices are the main threats to ecosystem structure and services of Mediterranean lakes. Therefore, it is essential to predict the future changes and develop mitigation measures to combat such pressures. In this study, Lake Beyşehir, the largest freshwater lake in the Mediterranean basin, was selected to study the impacts of climate change and various land use scenarios on the ecosystem dynamics of Mediterranean freshwater ecosystems and the services that they provide...
April 15, 2018: Science of the Total Environment
Eugenio Molina-Navarro, Hans E Andersen, Anders Nielsen, Hans Thodsen, Dennis Trolle
Water pollution and water scarcity are among the main environmental challenges faced by the European Union, and multiple stressors compromise the integrity of water resources and ecosystems. Particularly in lowland areas of northern Europe, high population density, flood protection and, especially, intensive agriculture, are important drivers of water quality degradation. In addition, future climate and land use changes may interact, with uncertain consequences for water resources. Modelling approaches have become essential to address water issues and to evaluate ecosystem management...
April 15, 2018: Science of the Total Environment
Emmanuelle Bourneuf
Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading to pathology, identify potential biomarkers to be used in the clinics, and eventually molecular targets for therapeutic solutions. Cutaneous melanoma, arising from skin melanocytes, is mainly caused by environmental factors such as UV radiation; however a significant genetic component participates in the etiology of the disease...
2017: Frontiers in Genetics
David Amabilino, Ioan Bâldea, Pol Besenius, Peter Beton, Matthew Blunt, Manfred Buck, Neil R Champness, Lifeng Chi, Stuart Clarke, Giovanni Costantini, Steven De Feyter, Yuri Diaz Fernandez, Deepak Dwivedi, Karl-Heinz Ernst, Amar Flood, Brandon Hirsch, Robert Jones, Angelika Kühnle, Markus Lackinger, Trolle R Linderoth, Natalia Martsinovich, Andrew Mount, Martin Nalbach, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Marco Sacchi, Sebastian Schwaminger, Steven L Tait, Phil Woodruff, Han Zuilhof
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
David Amabilino, Ioan Bâldea, James Batteas, Pol Besenius, Peter Beton, Manfred Buck, Lifeng Chi, Giovanni Costantini, Philip Davies, Steven De Feyter, Yuri Diaz Fernandez, Deepak Dwivedi, Karl-Heinz Ernst, Amar Flood, Brandon Hirsch, Vincent Humblot, Robert Jones, Angelika Kühnle, Markus Lackinger, Nian Lin, Trolle R Linderoth, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Marco Sacchi, Sebastian Schwaminger, Steven L Tait, Phil Woodruff, Han Zuilhof
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
David Amabilino, Ioan Bâldea, James Batteas, Peter Beton, Nerea Bilbao, Giovanni Costantini, Jonathan Davidson, Steven De Feyter, Yuri Diaz Fernandez, Karl-Heinz Ernst, Brandon Hirsch, Ahmad Jabbarzadeh, Robert Jones, Angelika Kühnle, Markus Lackinger, Zhi Li, Nian Lin, Trolle R Linderoth, Natalia Martsinovich, Martin Nalbach, Claire-Marie Pradier, Talat Rahman, Rasmita Raval, Neil Robinson, Federico Rosei, Marco Sacchi, Mario Samperi, Ana Sanz Matias, Alex Saywell, Sebastian Schwaminger, Steven L Tait
No abstract text is available yet for this article.
October 26, 2017: Faraday Discussions
Marzieh Araghi, Maria Rosaria Galanti, Michael Lundberg, Zhiwei Liu, Weimin Ye, Anton Lager, Gunnar Engström, Jonas Manjer, Lars Alfredsson, Anders Knutsson, Margareta Norberg, Richard Palmqvist, Björn Gylling, Patrik Wennberg, Ylva Trolle Lagerros, Rino Bellocco, Nancy L Pedersen, Per-Olof Östergren, Cecilia Magnusson
AIMS: Although smoking is considered to be an established risk factor for colorectal cancer, the current evidence on the association between smokeless tobacco and colorectal cancer is scant and inconclusive. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess this association. METHODS: A total of 417,872 male participants from nine cohort studies across Sweden were followed up for incidence of colorectal cancer and death...
July 1, 2017: Scandinavian Journal of Public Health
Ajiguli Nuermaimaiti, Yanxiao Ning, Jacob L Cramer, Katrine L Svane, Bjørk Hammer, Kurt V Gothelf, Trolle R Linderoth
Molecular conformational flexibility can play an important role in supramolecular self-assembly on surfaces, affecting not least chiral molecular assemblies. To explicitly and systematically investigate the role of molecular conformational flexibility in surface self-assembly, we synthesized a three-bit conformational switch where each of three switching units on the molecules can assume one of two distinct binary positions on the surface. The molecules are designed to promote C-H···N type hydrogen bonds between the switching units...
October 2, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Ylva Trolle Lagerros, Essi Hantikainen, Karl Michaëlsson, Weimin Ye, Hans-Olov Adami, Rino Bellocco
Physical activity has been inversely associated with the risk of hip fracture, however, few studies have been conducted on the contributions from different domains of physical activity. This study was performed to investigate the association between daily household activities, leisure time physical activity, work-related physical activity and total physical activity during a 24-h period, and the risk of hip fracture. In the Swedish National March Cohort we followed 23,881 men and women aged of 50 and over from 1997 until 2010...
November 2017: European Journal of Epidemiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"