keyword
https://read.qxmd.com/read/30003813/urocortin-3-gene-transfer-increases-function-of-the-failing-murine-heart
#21
JOURNAL ARTICLE
Dimosthenis Giamouridis, Mei Hua Gao, N Chin Lai, Zhen Tan, Young Chul Kim, Tracy Guo, Atsushi Miyanohara, Matthijs W Blankesteijn, Erik A L Biessen, H Kirk Hammond
Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography...
October 2, 2018: Human Gene Therapy
https://read.qxmd.com/read/29763816/design-of-a-phase-3-trial-of-intracoronary-administration-of-human-adenovirus-5-encoding-human-adenylyl-cyclase-type-6-rt-100-gene-transfer-in-patients-with-heart-failure-with-reduced-left-ventricular-ejection-fraction-the-flourish-clinical-trial
#22
JOURNAL ARTICLE
William F Penny, Timothy D Henry, Matthew W Watkins, Amit N Patel, H Kirk Hammond
The prognosis of patients with HFrEF remains poor despite the use of current medical and device therapies. Preclinical studies of HFrEF using IC delivery of RT-100, a replication deficient, E1/E3-deleted human adenovirus 5 encoding human AC6 was associated with favorable effects on LV function and remodeling. A recent multicenter, double-blind, placebo-controlled, phase 2 study demonstrated the safety of IC delivery of RT-100 in HFrEF patients and potential efficacy at the higher doses. This phase 2 dose finding study, which included doses not expected to be effective, identified a potential reduction in congestive heart failure admissions in the AC6-treated group one year after randomization...
July 2018: American Heart Journal
https://read.qxmd.com/read/29232881/the-genome-of-the-beluga-whale-delphinapterus-leucas
#23
JOURNAL ARTICLE
Steven J M Jones, Gregory A Taylor, Simon Chan, René L Warren, S Austin Hammond, Steven Bilobram, Gideon Mordecai, Curtis A Suttle, Kristina M Miller, Angela Schulze, Amy M Chan, Samantha J Jones, Kane Tse, Irene Li, Dorothy Cheung, Karen L Mungall, Caleb Choo, Adrian Ally, Noreen Dhalla, Angela K Y Tam, Armelle Troussard, Heather Kirk, Pawan Pandoh, Daniel Paulino, Robin J N Coope, Andrew J Mungall, Richard Moore, Yongjun Zhao, Inanc Birol, Yussanne Ma, Marco Marra, Martin Haulena
The beluga whale is a cetacean that inhabits arctic and subarctic regions, and is the only living member of the genus Delphinapterus . The genome of the beluga whale was determined using DNA sequencing approaches that employed both microfluidic partitioning library and non-partitioned library construction. The former allowed for the construction of a highly contiguous assembly with a scaffold N50 length of over 19 Mbp and total reconstruction of 2.32 Gbp. To aid our understanding of the functional elements, transcriptome data was also derived from brain, duodenum, heart, lung, spleen, and liver tissue...
December 11, 2017: Genes
https://read.qxmd.com/read/29232880/the-genome-of-the-northern-sea-otter-enhydra-lutris-kenyoni
#24
JOURNAL ARTICLE
Samantha J Jones, Martin Haulena, Gregory A Taylor, Simon Chan, Steven Bilobram, René L Warren, S Austin Hammond, Karen L Mungall, Caleb Choo, Heather Kirk, Pawan Pandoh, Adrian Ally, Noreen Dhalla, Angela K Y Tam, Armelle Troussard, Daniel Paulino, Robin J N Coope, Andrew J Mungall, Richard Moore, Yongjun Zhao, Inanc Birol, Yussanne Ma, Marco Marra, Steven J M Jones
The northern sea otter inhabits coastal waters of the northern Pacific Ocean and is the largest member of the Mustelidae family. DNA sequencing methods that utilize microfluidic partitioned and non-partitioned library construction were used to establish the sea otter genome. The final assembly provided 2.426 Gbp of highly contiguous assembled genomic sequences with a scaffold N50 length of over 38 Mbp. We generated transcriptome data derived from a lymphoma to aid in the determination of functional elements...
December 11, 2017: Genes
https://read.qxmd.com/read/29127278/the-north-american-bullfrog-draft-genome-provides-insight-into-hormonal-regulation-of-long-noncoding-rna
#25
JOURNAL ARTICLE
S Austin Hammond, René L Warren, Benjamin P Vandervalk, Erdi Kucuk, Hamza Khan, Ewan A Gibb, Pawan Pandoh, Heather Kirk, Yongjun Zhao, Martin Jones, Andrew J Mungall, Robin Coope, Stephen Pleasance, Richard A Moore, Robert A Holt, Jessica M Round, Sara Ohora, Branden V Walle, Nik Veldhoen, Caren C Helbing, Inanc Birol
Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines...
November 10, 2017: Nature Communications
https://read.qxmd.com/read/28767701/cardiac-directed-expression-of-a-catalytically-inactive-adenylyl-cyclase-6-protects-the-heart-from-sustained-%C3%AE-adrenergic-stimulation
#26
JOURNAL ARTICLE
Mei Hua Gao, N Chin Lai, Dimosthenis Giamouridis, Young Chul Kim, Tracy Guo, H Kirk Hammond
OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to β-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation. In the current study we test the hypothesis that cardiac-directed expression of AC6mut would protect the heart from sustained β-adrenergic receptor stimulation, a condition frequently encountered in patients with heart failure...
2017: PloS One
https://read.qxmd.com/read/28670631/cardiac-directed-expression-of-adenylyl-cyclase-catalytic-domain-reverses-cardiac-dysfunction-caused-by-sustained-beta-adrenergic-receptor-stimulation
#27
JOURNAL ARTICLE
Mei Hua Gao, N Chin Lai, Dimosthenis Giamouridis, Young Chul Kim, Zhen Tan, Tracy Guo, Wolfgang H Dillmann, Jorge Suarez, H Kirk Hammond
OBJECTIVE: To test the hypothesis that cardiac-directed expression of the cytoplasmic domains of adenylyl cyclase-6 (AC6) would have beneficial effects on the heart. BACKGROUND: Eliminating the two transmembrane domains of AC6 yields a protein with an intact catalytic domain that is disengaged from membrane-associated β-adrenergic receptor stimulation, but with enhanced propensity for intracellular interactions. METHODS: We constructed a peptide of the C1 and C2 segments of AC6 (C1C2), expressed C1C2 in an adenovirus vector and generated transgenic lines with cardiac-directed C1C2 expression, which underwent sustained isoproterenol (Iso) infusion...
December 2016: JACC. Basic to Translational Science
https://read.qxmd.com/read/28498861/modulation-of-caveolins-integrins-and-plasma-membrane-repair-proteins-in-anthracycline-induced-heart-failure-in-rabbits
#28
JOURNAL ARTICLE
Yasuhiro Ichikawa, Alice E Zemljic-Harpf, Zheng Zhang, M Dan McKirnan, Ana Maria Manso, Robert S Ross, H Kirk Hammond, Hemal H Patel, David M Roth
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart...
2017: PloS One
https://read.qxmd.com/read/28322590/randomized-clinical-trials-of-gene-transfer-for-heart-failure-with-reduced-ejection-fraction
#29
REVIEW
William F Penny, H Kirk Hammond
Despite improvements in drug and device therapy for heart failure, hospitalization rates and mortality have changed little in the past decade. Randomized clinical trials using gene transfer to improve function of the failing heart are the focus of this review. Four randomized clinical trials of gene transfer in heart failure with reduced ejection fraction (HFrEF) have been published. Each enrolled patients with stable symptomatic HFrEF and used either intracoronary delivery of a virus vector or endocardial injection of a plasmid...
May 2017: Human Gene Therapy
https://read.qxmd.com/read/27699250/one-time-injection-of-aav8-encoding-urocortin-2-provides-long-term-resolution-of-insulin-resistance
#30
JOURNAL ARTICLE
Mei Hua Gao, Dimosthenis Giamouridis, N Chin Lai, Evelyn Walenta, Vivian Almeida Paschoal, Young Chul Kim, Atsushi Miyanohara, Tracy Guo, Min Liao, Li Liu, Zhen Tan, Theodore P Ciaraldi, Simon Schenk, Aditi Bhargava, Da Young Oh, H Kirk Hammond
Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal within weeks, an effect that lasted for months. Hyperinsulinemic-euglycemic clamps showed reduced plasma insulin, increased glucose disposal rates, and increased insulin sensitivity following UCn2 gene transfer...
September 22, 2016: JCI Insight
https://read.qxmd.com/read/27686460/esicm-lives-2016-part-two-milan-italy-1-5-october-2016
#31
JOURNAL ARTICLE
S Sivakumar, F S Taccone, K A Desai, C Lazaridis, M Skarzynski, M Sekhon, W Henderson, D Griesdale, L Chapple, A Deane, L Williams, R Strickland, K Lange, D Heyland, M Chapman, M J Rowland, P Garry, J Westbrook, R Corkill, C A Antoniades, K T Pattinson, G Fatania, A J Strong, R B Myers, C Lazaridis, C M Jermaine, C S Robertson, C G Rusin, J Hofmeijer, L Sondag, M C Tjepkema-Cloostermans, A Beishuizen, F H Bosch, M J A M van Putten, L Carteron, C Patet, D Solari, M Oddo, M A Ali, C Dias, R Almeida, A Vaz-Ferreira, J Silva, E Monteiro, A Cerejo, A P Rocha, A A Elsayed, A M Abougabal, B N Beshey, K M Alzahaby, S Pozzebon, A Blandino Ortiz, S Cristallini, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, M Hravnak, K Yousef, Y Chang, E Crago, R M Friedlander, S A Abdelmonem, S A Tahon, T A Helmy, H S Meligy, F Puig, I Dunn-Siegrist, J Pugin, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, D S Tomar, M Shafi, R Harne, D P Arora, N Talwar, S Mazumdar, E E Papakrivou, D Makris, E Manoulakas, B Tsolaki, B Karadodas, E Zakynthinos, I Palacios Garcia, A Diaz Martin, V Sanchez Encinares, M Pachón Ibañez, J Garnacho Montero, G Labrador, T Cebrero Cangueiro, V Poulose, J Koh, J W Kam, H Yeter, A Kara, O Aktepe, A Topeli, I Tsolakoglou, G Intas, P Stergiannis, A A Kolaros, E Chalari, E Athanasiadou, A Martika, G Fildisis, V Faivre, C Mengelle, B Favier, D Payen, A Poppe, M S Winkler, E Mudersbach, J Schreiber, M L Wruck, E Schwedhelm, S Kluge, C Zöllner, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, A García-de la Torre, M V de la Torre-Prados, T Tsvetanova-Spasova, P Nuevo-Ortega, C Rueda-Molina, A Fernández-Porcel, E Camara-Sola, L Salido-Díaz, A García-Alcántara, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, D E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, B Suberviola, J Riera, L Rellan, M Sanchez, J C Robles, E Lopez, R Vicente, E Miñambres, M Santibañez, M Le Guen, J Moore, N Mason, M Windpassinger, O Plattner, E Mascha, D I Sessler, Outcomes Research, U Melia, J Fontanet, J P van den Berg, M M R F Struys, H E M Vereecke, E W Jensen, P J T Rood, F van de Schoor, K van Tertholen, P Pickkers, M van den Boogaard, Z J Beardow, H Redhead, K Paramasivam, T Numan, M van den Boogaard, A M Kamper, P Rood, L M Peelen, P M Zeman, A J Slooter, C E van Ewijk, G E Jacobs, A R J Girbes, S N Myatra, M M Harish, N R Prabu, S Siddiqui, A P Kulkarni, J V Divatia, L D Murbach, M A Leite, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, N Hernández-Sánchez, L A Sánchez-Hurtado, F J García-Guillen, S A Ñamendys-Silva, B Maghsoudi, M Emami, M B Khosravi, F Zand, H R Tabatabaie, M Masjedi, G Sabetiyan, A Mokri, J Troubleyn, M Diltoer, R Jacobs, D N Nguyen, E De Waele, J De Regt, P M Honoré, V Van Gorp, H D Spapen, R S Contreras, N D Toapanta, G Moreno, J Sabater, H Torrado, M Gonzalez, M Marin, E Farigola, A Gonzalez, J Fernandez, A Vera, X Gisbert, C Juliá, J Uya, L Corral, I Elias-Jones, L Gemmell, A MacKay, D Randall, A Adwaney, M Blunden, J R Prowle, C J Kirwan, N Thomas, A Martin, H Owen, L Darwin, D Conway, D Atkinson, M Sharman, J Moore, C Barbanti, J Amour, P Gaudard, B Rozec, P Mauriat, M M'rini, P L Leger, G Cambonie, J M Liet, C Girard, S Laroche, P Damas, Z Assaf, G Loron, L Lecourt, P Pouard, D Randall, A Adwaney, M Blunden, J R Prowle, C J Kirwan, S H Kim, S Na, J Kim, S Y Oh, C W Jung, S H Yoo, S H Min, E J Chung, H Lee, N J Lee, K W Lee, K S Suh, H G Ryu, D C Marshall, R J Goodson, J D Salciccioli, J Shalhoub, E K Potter, J Kirk-Bayley, N D Karanjia, L G Forni, B C Creagh-Brown, M Bossy, M Nyman, A Tailor, B Creagh-Brown, D D'Antini, S Spadaro, F Valentino, F Sollitto, G Cinnella, L Mirabella, F J Redondo Calvo, N Bejarano, D Padilla, V Baladron, P Villajero, R Villazala, J Redondo, A S Yuste, J Liu, F Shen, J L Teboul, N Anguel, A Beurton, N Bezaz, C Richard, X Monnet, T Fossali, R Colombo, D Ottolina, M Rossetti, C Mazzucco, A Marchi, A Porta, E Catena, K H Tollisen, G Ø Andersen, F Heyerdahl, D Jacobsen, M C de Waard, A R J Girbes, M C O van IJzendoorn, H Buter, W P Kingma, G J Navis, E C Boerma, J Rulisek, M Balik, S Zacharov, H S Kim, S J Jeon, H Namgung, E Lee, E Lee, Y J Cho, Y J Lee, A Huang, L Cioccari, N Luethi, J Mårtensson, R Bellomo, M Forsberg, G Edman, J Höjer, S Forsberg, M T Chiquito Freile, F N Hidalgo, J A Martinez Molina, R Lecumberri, A Figuerola Rosselló, P Medrano Travieso, G Tuero Leon, J Gonzalez Sanchez, L Sahuquillo Frias, D Balsells Rosello, J A Garcia Verdejo, J A Noria Serrano, D Winterwerp, T van Galen, A Vazin, I Karimzade, A Zand, E Ozen, S Ekemen, A Akcan, E Sen, B Buyukkidan Yelken, N Kureshi, L Fenerty, G Thibault-Halman, M Erdogan, S Walling, R S Green, D B Clarke, P Briassoulis, K Kalimeris, A Ntzouvani, T Nomikos, K Papaparaskeva, E Politi, G Kostopanagiotou, K Crewdson, M Rehn, A Weaver, K Brohi, D Lockey, S Wright, K Thomas, C Baker, L Mansfield, V Stafford, C Wade, G Watson, A Bryant, T Chadwick, J Shen, J Wilkinson, J Furneval, A Henderson, K Hugill, P Howard, A Roy, S Bonner, S Baudouin, C Sánchez Ramírez, S Hípola Escalada, M A Hernández Viera, M Cabrera Santana, L Caipe Balcázar, N Sangil Monroy, F Artiles Campelo, C F Lübbe Vázquez, P Saavedra Santana, S Ruiz Santana, L Carteron, C Patet, H Quintard, D Solari, P Bouzat, M Oddo, T Wollersheim, J Malleike, K Haas, N Carbon, J Schneider, C Birchmeier, J Fielitz, S Spuler, S Weber-Carstens, L Enseñat, A Pérez-Madrigal, P Saludes, L Proença, G Gruartmoner, C Espinal, J Mesquida, W Huber, M Eckmann, F Elkmann, A Gruber, T Lahmer, U Mayr, A Herner, R Schellnegger, J Schneider, R M Schmid, W Ayoub, W Samy, A Esmat, A Battah, S Mukhtar, W Mongkolpun, D Orbegozo Cortés, C P R Cordeiro, J L Vincent, J Creteur, S Funcke, H Groesdonk, B Saugel, G Wagenpfeil, S Wagenpfeil, D A Reuter, M M Fernandez, R Fernandez, M Magret, A González-Castro, M T Bouza, M Ibañez, C García, B Balerdi, A Mas, V Arauzo, J M Añón, F Ruiz, J Ferreres, R Tomás, M Alabert, A I Tizón, S Altaba, N Llamas, E C Goligher, E Fan, M Herridge, S Vorona, M Sklar, M Dres, N Rittayamai, A Lanys, C Urrea, G Tomlinson, W D Reid, G D Rubenfeld, B P Kavanagh, L J Brochard, N D Ferguson, A Serpa Neto, M Gama de Abreu, P Pelosi, M J Schultz, C Guérin, L Papazian, J Reignier, L Ayzac, A Loundou, J M Forel, C Rolland-Debord, C Bureau, T Poitou, M Clavel, S Perbet, N Terzi, A Kouatchet, T Similowski, A Demoule, N Hunfeld, Z Trogrlic, S Ladage, R J Osse, B Koch, W Rietdijk, J Devlin, M van der Jagt, E Picetti, P Ceccarelli, F Mensi, L Malchiodi, S Risolo, I Rossi, M V Antonini, F Servadei, M L Caspani, A Roquilly, S Lasocki, P Seguin, T Geeraerts, P F Perrigault, C Dahyot-Fizelier, C Paugam-Burtz, F Cook, R Cinotti, D Demeure Dit Latte, P J Mahe, C Fortuit, F Feuillet, K Asehnoune, C Marzorati, S Spina, V Scaravilli, A Vargiolu, M Riva, C Giussani, E Sganzerla, G Citerio, S Barbadillo, F J González de Molina, F Álvarez-Lerma, A Rodríguez, T Zakharkina, I Martin-Loeches, S Matamoros, P Povoa, A Torres, J Kastelijn, J J Hofstra, M de Jong, M Schultz, P Sterk, A Artigas, L J Bos, A S Moreau, I Martin-Loeches, P Povoa, J Salluh, A Rodriguez, S Nseir, E de Jong, J A van Oers, A Beishuizen, A R J Girbes, M W N Nijsten, D W de Lange, D Bonvicini, D Labate, L Benacchio, A Olivieri, E Pizzirani, J C Lopez-Delgado, M Gonzalez-Romero, V Fuentes-Mila, D Berbel-Franco, I Romera-Peregrina, A Martinez-Pascual, J Perez-Sanchez, R Abellan-Lencina, R E Ávila-Espinoza, G Moreno-Gonzalez, F Sbraga, S Griffiths, M P W Grocott, B Creagh-Brown, J Doyle, P Wilkerson, Y Soon, S Huddart, M Dickinson, A Riga, A Zuleika, K Miyamoto, Y Kawazoe, T Morimoto, T Yamamoto, A Fuke, A Hashimoto, H Koami, S Beppu, Y Katayama, M Ito, Y Ohta, H Yamamura, S L Rygård, L B Holst, J Wetterslev, P I Johansson, A Perner, I W Soliman, D W de Lange, D van Dijk, J J M van Delden, O L Cremer, A J C Slooter, L M Peelen, D McWilliams, C Snelson, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, M Veronesi, A Lischinsky, F J L López, L Benito Mori, G Plotnikow, A Díaz, S Giannasi, R Hernandez, L Krzisnik, C Cecotti, L Viola, R Lopez, J P Sottile, G Benavent, E Estenssoro, C M Chen, C C Lai, K C Cheng, W Chou, K S Chan, L E Roeker, C M Horkan, F K Gibbons, K B Christopher, P J M Weijs, K M Mogensen, J D Rawn, M K Robinson, K B Christopher, Z Tang, C Qiu, B Ouyang, C Cai, X Guan, T Regueira, L Cea, S Juan Carlos, B Elisa, C Puebla, A Vargas, M K Poulsen, L P Thomsen, S Kjærgaard, S E Rees, D S Karbing, T Wollersheim, S Frank, M C Müller, N M Carbon, V Skrypnikov, P A Pickerodt, R Falk, A Mahlau, S Weber-Carstens, A Lee, R Inglis, R Morgan, G Barker, K Kamata, T Abe, D Saitoh, Y Tokuda, R S Green, M B Butler, M Erdogan, H Tae Hwa, L Jae Gil, R Hernández Vaquero, E Rodriguez-Ruiz, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, D O Thomas-Rüddel, D Schwarzkopf, C Fleischmann, K Reinhart, S Suwanpasu, Y Sattayasomboon, N M Filgueiras Filho, J C A Oliveira, C S Ballalai, C V De Lucia, G P Araponga, L N Veiga, C S Silva, M E Garrido, B B Ramos, E F Ricaldi, S S Gomes, L Gemmell, A MacKay, C Wright, R I Docking, P Doherty, E Black, P Stenhouse, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, T Yatabe, S Inoue, M Sakaguchi, M Egi, Y Ali Abdelhamid, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, M Hokka, M Egi, S Mizobuchi, P Kar, M Plummer, Y Ali Abdelhamid, E Giersch, M Summers, S Hatzinikolas, S Heller, M Chapman, K Jones, M Horowitz, A Deane, R Schweizer, M Jacquet-Lagreze, P Portran, S Junot, B Allaouchiche, J L Fellahi, P Guerci, B Ergin, A Kapucu, C Ince, L Cioccari, N Luethi, M Crisman, R Bellomo, J Mårtensson, C Righy Shinotsuka, D Fagnoul, A Brasseur, D Orbegozo, J L Vincent, J C Preiser, J C Preiser, O Lheureux, A Thooft, S Brimioulle, J L Vincent, H Iwasaka, S Tahara, M Nagamine, A Ichigatani, A Rugerio Cabrera, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, A A Tanaka Montoya, A Pedraza Montenegro, G A Gálvez Blanco, C M Coronado Robles, A Drolz, T Horvatits, K Roedl, K Rutter, S Kluge, G C Funk, B Schneeweiss, V Fuhrmann, G Sabetian, F Pooresmaeel, F Zand, S Ghaffaripour, A Farbod, H Tabei, L Taheri, R Anandanadesan, V Metaxa, C Teixeira, S M Pereira, P Hernández-Marrero, A S Carvalho, M Beckmann, C S Hartog, D Schwarzkopf, A Raadts, A Robertsen, R Førde, N O Skaga, E Helseth, S Honeybul, K Ho, P Martinez Lopez, M Nieto Gonzalez, P Nuevo Ortega, E Camara Sola, T Spasova, M V de la Torre-Prados, O Kopecky, K Rusinova, P Waldauf, Z Cepeplikova, M Balik, J Palamidessi Domínguez, P Matia Almudevar, S Alcántara Carmona, J J Rubio Muñoz, D Palacios Castañeda, A Naharro Abellán, P Rodríguez Villamizar, J Veganzones Ramos, L Pérez Pérez, A Pérez Lucendo, M Camós Ejarque, A Estella, V Lopez Camps, M C Martín, N Masnou, S Barbosa, A Varela, I Palma, L Cristina, E Nunes, I Pereira, G Campello, C Granja, R Pande, M Pandey, S Varghese, M Chanu, M J Van Dam, E W M T Ter Braak, A Estella, M Gracia, R Viciana, M Recuerda, L Perez Fontaiña, B Tharmalingam, F Kovari, L Rose, M Mcginlay, R Amin, K Burns, B Connolly, N Hart, P Jouvet, S Katz, D Leasa, C Mawdsley, D Mcauley, M Schultz, B Blackwood, S Denham, R Worrall, M Arshad, P Isherwood, A Khadjibaev, D Sabirov, A Rosstalnaya, F Parpibaev, V Sharipova, G A Galvez Blanco, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, M Shafi, D S Tomar, R Harne, D P Arora, N Talwar, S Mazumdar, Y S Cha, S J Lee, N Tyagi, R K Rajput, S Taneja, V K Singh, S C Sharma, S Mittal, B K Rao, J Ayachi, N Fraj, S Romdhani, A Khedher, K Meddeb, N Sma, A Azouzi, R Bouneb, I Chouchene, M El Ghardallou, M Boussarsar, R Jennings, E Walter, J M Ribeiro, I Moniz, R Marçal, A C Santos, C Candeias, Z Costa E Silva, S E Zamora Gomez, O R Perez Nieto, J A Castanon Gonzalez, A I Vasquez Cuellar, H Mildh, V Pettilä, A M Korhonen, S Karlsson, T Ala-Kokko, M Reinikainen, S T Vaara, M Zaleska-Kociecka, M Grabowski, M Dąbrowski, S Wozniak, K Piotrowska, M Banaszewski, J Imiela, J Stepinska, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, J Koeze, F Keus, W Dieperink, I C C van der Horst, M van Meurs, J G Zijlstra, S Roberts, C Hernandez Caballero, G Isgro, D Hall, S Beitland, A-M S Trøseid, B S Brusletto, B E Waldum-Grevbo, J P Berg, K Sunde, D García Huertas, F Manzano, M M Jiménez- Quintana, A Osuna, F Santiago-Ruiz, C Rodríguez-Mejías, R Wangensteen, H R Jamaati, M Masjedi, F Zand, S M R Hashemian, G Sabetian, G Abbasi, V Khaloo, S H A Tabei, A Kafilzadeh, H Haddad Bakhodaei, J A Diaz, R Silva, D J Garcia, E Luis, M N Gomez, R Soriano, P L Gonzalez, I A Ibrahim, M M Rafik, A M Al-Ansary, M A Algendi, A A Ali, V Fuhrmann, K Roedl, T Horvatits, A Drolz, K Rutter, D Benten, J Kluwe, S Siedler, S Kluge, I Adedugbe, G T Bird, R M Kennedy, S Sharma, M B Butler, G Yugi, B A Haroon, T Witter, W Khaliq, M Singer, A A Havaldar, B Krishna, S Sriram, E D Valenzuela Espinoza, M O Pozo, V S Kanoore Edul, M Furche, M F Motta, A Risso Vazquez, P N Rubatto Birri, C Ince, A Dubin, A Dogliotti, A Ramos, C Lovesio, E Delile, R Nevière, P-A Thiébaut, J Maupoint, P Mulder, D Coquerel, S Renet, J C do Rego, J Rieusset, V Richard, F Tamion, W Khaliq, D T Andreis, M Singer, B Smit, Y M Smulders, M C de Waard, H M Oudemans van Straaten, A R J Girbes, E C Eringa, A M E Spoelstra-de Man, L Alegría, D Soto, C Luengo, J Gomez, N Jarufe, A Bruhn, R Castro, E Kattan, P Tapia, R Rebolledo, P Achurra, G Ospina-Tascón, J Bakker, G Hernández, P Bertini, F Guarracino, R Baldassarri, M R Pinsky, L Alegría, M Vera, J Dreyse, D Carpio, C Henriquez, D Gajardo, S Bravo, R Castro, G Ospina-Tascón, J Bakker, G Hernández, S Kim, M Lee, S Y Park, S So, H Lee, M B Kačar, S M Kačar, I Uddin, A M Belhaj, M A Aydın, D Avsec, A Kapuağası, Ç Kaymak, L Kovach, I Şencan, B Meço, M Özçelik, N Ünal, C Lazaridis, B Jenni-Moser, M-M Jeitziner, M S Galassi, F L Sales, K C L de Moraes, C L Batista, J A de Souza Júnior, T B Marcari, R Lobato, C S A A Castro, L M de Souza, F F P Rodrigues, N G Correa, A M Pelegrini, R A C Eid, K T Timenetsky, D Cazati, M Lobato, P S Diniz, L L Rocha, A M Cavalheiro, N M Lucinio, E R Santos, M Norrenberg, A Gleize, J C Preiser, I Fernández Simón, S Alcántara Carmona, I Lipperheide Valhonrat, J Palamidessi Domínguez, A Naharro Abellán, P Matía Almudévar, F Dávila, J J Rubio, A J Ramos, Á J Roldán Reina, N Palomo López, M Adriaensens Pérez, D X Cuenca Apolo, L Martín Villén, F M Porras López, I Palacios García, J R Naranjo Izurieta, J J Egea Guerrero, S Calvert, M Quint, K Adeniji, R Young, D D Shevill, E Robertson, P Garside, E Walter, P Isotti, M M De Vecchi, A E Perduca, A Negro, G Villa, D F Manara, L Cabrini, A Zangrillo, J F Frencken, L van Baal, L M Peelen, D W Donker, J Horn, T van der Poll, W A van Klei, M J M Bonten, O L Cremer, C E Menard, A Kumar, E Rimmer, S Doucette, A F Turgeon, B L Houston, D S Houston, R Zarychanski, B Bollen Pinto, M Carrara, M Ferrario, K Bendjelid, J Nunes, P Diaz, G Silva, S Escórcio, S Chaves, M Jardim, N Fernandes, M Câmara, R Duarte, C A Pereira, J Vieira, J J Nóbrega, C M Coronado Robles, M A Montes de Oca-Sandoval, A Sánchez-Rodríguez, J G Joya-Galeana, A Correa-Morales, G Camarena-Alejo, J Aguirre-Sánchez, J Franco-Granillo, M Soliman, A Al Azab, R El Hossainy, H Nagy, M Nirmalan, I A Crippa, F Zama Cavicchi, J L Vincent, J Creteur, F S Taccone, A Chaari, K Abdel Hakim, H Hassanein, M Etman, M El Bahr, K Bousselmi, E S Khalil, V Kauts, W F Casey, H Imahase, Y Sakamoto, S Inoue, K C Yamada, H Koami, T Miike, F Nagashima, T Iwamura, A Boscolo, V Lucchetta, E Piasentini, D Bertini, L Manesso, L Spiezia, P Simioni, C Ori, R B Souza, A M Martins, A M A Liberatore, Y R Kang, M N Nakamae, J C F Vieira, I H J Koh, K Hanslin, F Wilske, P Skorup, J Sjölin, M Lipcsey, W Jin Long, C Er Zhen, A Vakalos, V Avramidis, S H Wu, L J Shyu, C H Li, C H Yu, H C Chen, C H Wang, K H Lin, Z E Aray, C F Gómez, A P Tejero, D D Monge, V M Losada, C M Tarancón, S D Cortés, A M Gutiérrez, T P Álvarez, A Rouze, K Jaffal, S Six, K Stolz, V Cattoen, S Nseir, J M Arnal, M Saoli, D Novotni, A Garnero, T Becher, V Buchholz, D Schädler, I Frerichs, N Weiler, N Eronia, T Mauri, S Gatti, E Maffezzini, A Bronco, L Alban, T Sasso, C Marenghi, G Grasselli, A Pesenti, G Bellani, A Al-Fares, L Del Sorbo, S Anwar, F Facchin, S Azad, R Zamel, N Ferguson, M Cypel, S Keshavjee, E Fan, E Durlinger, A Spoelstra-de Man, B Smit, H J de Grooth, A Girbes, H Oudemans-van Straaten, Y Smulders, M A Alfaro, F Parrilla, A Meli, M Pellegrini, N Rodriguez, J M Goyeneche, I Morán, H Aguirre, J Mancebo, S J H Heines, U Strauch, D C J J Bergmans, P Blankman, A Shono, D Hasan, D Gommers, W Y Chung, K S Lee, Y J Jung, J H Park, S S Sheen, K J Park, R Worral, S Denham, P Isherwood, S E Rees, S Larraza, N Dey, S Spadaro, J B Brohus, R W Winding, C A Volta, D S Karbing, F Ampatzidou, A Vlachou, G Kehagioglou, T Karaiskos, A Madesis, C Mauromanolis, N Michail, G Drossos, N Saraj, S Rijkenberg, H M Feijen, H Endeman, A A J Donnelly, E Morgan, H Garrard, H Buckley, L Russell, N Haase, A Perner, C Goh, K Mouyis, C L N Woodward, J Halliday, G B Encina, J Ros, L Lagunes, J Tabernero, F Bosch, J Rello, D García Huertas, F Manzano, E Morente-Constantin, B Rivera-Ginés, M Colmenero-Ruiz, A Naharro Abellán, L Pérez Pérez, A Pérez Lucendo, P Matía Almudévar, J Palamidessi Domínguez, P Rodríguez Villamizar, J García Sanz, I Fernandez Simon, B Lobo Valbuena, S Alcantara Carmona, M Pais, S Ramalingam, C Díaz, L Fox, M Santafe, P Barba, M García, S Leal, M Pérez, M L Pérez Pérez, A Naharro Abellán, A Pérez Lucendo, P Matia Almudevar, J Palamidessi Domínguez, P Rodríguez Villamizar, J Veganzones, I Fernandez Simón, B Lobo Valbuena, N Martínez, S Alcántara Carmona, I Moors, D Mokart, F Pène, J Lambert, A Kouatchet, J Mayaux, F Vincent, M Nyunga, F Bruneel, L Laisne, A Rabbat, C Lebert, P Perez, M Chaize, A Renault, A P Meert, R Hamidfar, M Jourdain, M Darmon, B Schlemmer, S Chevret, V Lemiale, E Azoulay, D Benoit, D Martins-Branco, M Sousa, S Marum, M J Bouw, G Galstyan, P Makarova, E Parovichnikova, L Kuzmina, V Troitskaya, N Drize, E Gemdzhian, V Savchenko, H C Chao, E Kılıc, B Demiriz, M L Uygur, M Sürücü, K Cınar, A E Yıldırım, K Kiss, B Köves, V Csernus, Z Molnár, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, S Gaffney, E Black, R Docking, C Judge, T Drew, H Misran, R Munshi, L McGovern, M Coyle, L Dunne, E Deasy, P Lavin, A Fahy, D M Darcy, M Donnelly, N H Ismail, T Hall, K Wykes, J Jack, W C Ngu, P Morgan, J Ruiz-Ramos, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andrés, A Castellanos, C E Ijssennagger, S Ten Hoorn, A van Wijk, J M van den Broek, P R Tuinman, A M Elmenshawy, B D Hammond, G Gibbon, T Belcham, K Burton, L U Taniguchi, F J S Ramos, A K Momma, A P R Martins-Filho, J J Bartocci, M F D Lopes, M H Sad, C M Rodrigues, E M C Pires, J M Vieira, M A Leite, L D Murbach, E F Osaku, J Barreto, S T Duarte, S Taba, D Miglioranza, D P Gund, C F Lordani, C R L M Costa, S M Ogasawara, A C Jorge, P A D Duarte, S Spadaro, M Capuzzo, F Dalla Corte, S Terranova, G Scaramuzzo, A Fogagnolo, S Bertacchini, A Bellonzi, R Ragazzi, C A Volta, C Cruz, A Nunes, F Seabra Pereira, I Aragão, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, J Paratz, J Kenardy, T Comans, F Coyer, P Thomas, R Boots, N Pereira, A Vilas-Boas, E Gomes, C Dias, J Torres, D Carvalho, E Molinos, C Vales, R Araújo, C Cruz, A Nunes, F Seabra Pereira, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, L Karnatovskaia, K Philbrick, G Ognjen, M Clark, R Molina Montero, J Luján Varas, L Alcázar Sánchez-Elvira, C Pintado Delgado, P Villa Díaz, B Llorente Ruiz, A Pardo Guerrero, J A Cambronero Galache, R Jiménez, S Rebollo, O Alejandro, A Fernández, S Moreno, L Herrera, A Ojados, M Galindo, J Murcia, M Contreras, S Sánchez-Argente, Y Bonilla, M D Rodríguez, J M Allegue, Ö Cakin, H Parlak, H Kirca, F Mutlu, B Aydınlı, M Cengiz, A Ramazanoglu, E-J Jung, S-Y Oh, H Lee, N M Filgueiras Filho, E F Ricaldi, S S Gomes, B B Ramos, C V De Lucia, C S Ballalai, J C A Oliveira, G P Araponga, L N Veiga, C S Silva, M E Garrido, J Cebrián Domenech, A Pinos Montalvo, T Ciges Chornet, P Concha Martinez, M Piñol Ribas, R Gimeno Costa, A Castellanos Ortega, C Forbes, H Prescott, A Lal, F A Khan, E G Dela Pena, J S Dizon, P P P Perez, C M J Wong, M Muñoz Garach, O Moreno Romero, R Ramirez Puerta, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, M S Kalaiselvan, R L Siva Kumar, M K Renuka, A S Arun Kumar, S De Rosa, F Ferrari, S Carboni Checcacci, A Rigobello, M Joannidis, F Politi, A Pellizzari, R Bonato, A Fernandez-Carmona, I Macias-Guarasa, R Gutierrez-Rodriguez, P Martinez-Lopez, M A Diaz-Castellanos, A Fernandez-Carmona, M Arias-Diaz, E Aguilar-Alonso, I Macias-Guarasa, P Martinez-Lopez, M A Diaz-Castellanos, R N Nikandish, V Artemenko, A Budnyuk, G Li Bassi, T Senussi, F Idone, E Aguilera Xiol, C Travierso, C Chiurazzi, A Motos, R Amaro, Y Hua, L Fernández-Barat, O T Ranzani, Q Bobi, M Rigol, A Torres, A Youn, J Gyung Hwang, M Muñoz Garach, O Moreno Romero, M E Yuste Ossorio, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, C Teixeira, H Figueira, R Oliveira, A Mota, I Aragão, O Kamp, O Cruciger, M Aach, C Kaczmarek, C Waydhas, T A Schildhauer, U Hamsen, M Camprubí-Rimblas, L Chimenti, R Guillamat-Prats, T Lebouvier, J Bringué, J Tijero, M N Gómez, L Blanch, A Artigas, G Tagliabue, M Ji, J V Suneby Jagers, P A Easton, R B Souza, A M A Liberatore, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, J Y Hong, M H Shin, M S Park, A Pomprapa, P A Pickerodt, M B T Hofferberth, M Russ, W Braun, M Walter, R Francis, B Lachmann, S Leonhardt, I H J Koh, R B Souza, A M C R P F Martins, J C F Vieira, A M A Liberatore, A Landaverde-López, N A Canedo-Castillo, A Esquivel-Chávez, P C Arvizu-Tachiquín, L A Sánchez-Hurtado, J A Baltazar-Torres, V Cardoso, A Krystopchuk, S Castro, L Melão, S Firmino, A Marreiros, C Granja, S Almaziad, A Kubbara, W Barnett, R Nakity, W Alamoudi, R Altook, T Tarazi, M Fida, F Safi, R Assaly, A Santini, M Milesi, T Maraffi, P Pugni, D T Andreis, M Cavenago, L Gattinoni, A Protti, G Perchiazzi, J B Borges, S Bayat, L Porra, L Broche, M Pellegrini, G Scaramuzzo, G Hedenstierna, A Larsson, M Pellegrini, G Hedenstierna, A Roneus, M Segelsjö, M C Vestito, A Larsson, G Perchiazzi, E Gremo, A Nyberg, M Castegren, A Pikwer, T Yoshida, D Engelberts, G Otulakowski, B Katira, M Post, N D Ferguson, L Brochard, M B P Amato, B P Kavanagh, N Koch, W Huber, J Hoellthaler, S Mair, V Phillip, R M Schmid, A Beitz, V Baladrón, F J Redondo Calvo, D Padilla, P Villarejo, R Villazala, A S Yuste, N Bejarano, R J Steenstra, H Banierink, J Hof, I C van der Horst, M W Nijsten, M Hoekstra, K Roedl, F Sterz, T Horvatits, K Horvatits, A Drolz, H Herkner, V Fuhrmann, M Kott, K Zitta, B Brandt, C Schildhauer, G Elke, L Hummitzsch, I Frerichs, N Weiler, M Albrecht, L Rey González, D Cabestrero Alonso, A Blandino Ortiz, R de Pablo Sánchez, J Higuera Lucas, K Roedl, F Sterz, A Drolz, K Horvatits, T Horvatits, H Herkner, V Fuhrmann, T Horvatits, A Drolz, K Roedl, K Rutter, A Ferlitsch, G Fauler, M Trauner, V Fuhrmann, T Horvatits, S Pischke, L Fischer, F Thaiss, M Koch, K Bangert, V Fuhrmann, S Kluge, A W Lohse, B Nashan, M Sterneck, S Faenza, A Siniscalchi, E Pierucci, E Mancini, D Ricci, C Gemelli, A Cuoghi, S Magnani, M Atti, F Sotos, J Cánovas, A López, A Burruezo, D Torres, M E Herrera-Gutierrez, J Barrueco-Francioni, D Arias-Verdú, R Lozano-Saez, G Quesada-Garcia, G Seller-Pérez, A Figueiredo, Y Anzola, R Pereira, L Bento, D Arias-Verdú, M Lai, M Deiana, J Barrueco-Francioni, M E Herrera-Gutierrez, G Seller-Perez, K Vardas, S Ilia, A Sertedaki, E Charmadari, C A Stratakis, E Briassouli, D Goukos, K Psarra, E Botoula, S Tsagarakis, E Mageira, C Routsi, S Nanas, G Briassoulis, A Boscolo, D Bertini, E Campello, V Lucchetta, E Piasentini, C M Radu, L Manesso, P Simioni, C Ori, H Su, Y M Lam, K Willis, V Pullar, R P Hubner, J L Tsang, L García de Guadiana-Romualdo, S Rebollo-Acebes, P Esteban-Torrella, R Jiménez-Sánchez, E Jiménez-Santos, A Ortín-Freire, A Hernando-Holgado, M D Albaladejo-Otón, L Coelho, L Rabello, J Salluh, I Martin-Loeches, A Rodriguez, S Nseir, P Póvoa, E Varis, V Pettilä, M Poukkanen, S Jacob, S Karlsson, A Perner, J Takala, E Wilkman, O H M Lundberg, L Bergenzaun, J Rydén, M Rosenqvist, O Melander, M S Chew, E Rodriguez-Ruiz, R Hernández Vaquero, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, Y Kishihara, H Yasuda, S Rebollo, L García de Guadiana-Romualdo, R Jimenez, P Esteban Torrella, A Fernandez, S Sanchez, A Ortin, G Li Bassi, R Guillamat Prats, A Artigas, E Aguilera, D Marti, O T Ranzani, M Rigol, L Fernandez, M Ferrer, I Martin-Loeches, A Torres, V S Lanziotti, P Póvoa, L Pulcheri, M O Ribeiro, A P Barbosa, J R Lapa E Silva, M Soares, J I F Salluh, I Palacios Garcia, A Diaz Martin, M Gil Marqués, A Puppo Moreno, A Gutierrez Pizarraya, J Pachón Diaz, M Pachón Ibañez, Y Smani, M Mc Connell, L A Zhang, R S Parker, I Banerjee, G Clermont, E Norberg, J Oras, A Cuisinier, C Maufrais, J F Payen, S Nottin, G Walther, P Bouzat, S Arib, F Bilotta, R Badenes, F Rubulotta, S Mirek, I A Crippa, B Monfort, E Stazi, A Lozano Roig, J Creteur, F S Taccone, S Magnoni, M Marando, S Pifferi, V Conte, F Ortolano, M Carbonara, G Bertani, E Scola, M Cadioli, F Triulzi, A Colombo, N Stocchetti, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Guimillo, C Sanchís Piqueras, J Romero Guia, M García Simon, A Mesejo Arizmendi, A Carratalá, S El Maraghi, A Yehia, M Bakry, A Shoman, F N Backes, M M Bianchin, S R R Vieira, A de Souza, A N Backes, C Klein, M S Kalaiselvan, M K Renuka, A S Arunkumar, A Lozano, O Lheureux, R Badenes, J L Vincent, J Creteur, F S Taccone, C Gallaher, S Cattlin, S Gordon, J Picard, V Fontana, O Bond, L Nobile, J L Vincent, J Creteur, F S Taccone, S Mrozek, L Delamarre, F Capilla, T Al-Saati, O Fourcade, T Geeraerts, A M Dominguez-Berrot, M Gonzalez-Vaquero, M E Vallejo-Pascual, D Gupta, B D Ivory, M Chopra, J McCarthy, C L Felderhof, C MacNeil, F Rubulotta, P Waldauf, M Maggiorini, F Duska, R R L Fumis, J M Vieira Junior, G Amarante, A Skorko, S Sanders, J Aron, R J Kroll, C Redfearn, P Krishnan, J E Khalil, F Kovari, N Kongpolprom, V Gulia, E Lourenço, L Melão, C Duro, G Baptista, A Alves, B Arminda, M Rodrigues, A Marreiros, C Granja, J Hayward, F Baldwin, R Gray, P A Katinakis, M Stijf, M Ten Kleij, M Jansen-Frederiks, R Broek, M de Bruijne, P E Spronk, K Sinha, M Luney, K Palmer, L Keating, M Abu-Habsa, R Bahl, N Baskaralingam, A Ahmad, L Kanapeckaite, P Bhatti, S Glace, S Jeyabraba, H F Lewis, A Kostopoulos, M Raja, A West, A Ely, L M Turkoglu, P Zolfaghari, J P Baptista, M P Marques, P Martins, J Pimentel, D Gupta, Y C Su, S Villacres, M E Stone, A Parsikia, S Medar, K P O'Dea, J Porter, N Tirlapur, J M Jonathan, S Singh, M Takata, M Abu-Habsa, A Ahmad, E McWhirter, R Lyon, M L Hariz, E Azmi, J Alkhan, S Honeybul, V Movsisyan, S Petrikov, Z Marutyan, I Aliev, A Evdokimov, E Antonucci, T Merz, C Hartmann, P Pelosi, E Calzia, P Radermacher, B Nußbaum, C Hartmann, M Huber-Lang, M Gröger, P Radermacher, B Nußbaum, B Nußbaum, E Antonucci, E Calzia, P Pelosi, P Radermacher, C Hartmann, E Svoren-Jabalera, E E Davenport, P Humburg, J Knight, C J Hinds, I J Jun, W J Kim, E H Lee, G Besch, A Perrotti, M Puyraveau, L Carteron, M Baltres, E Samain, S Chocron, S Pili-Floury, E P Plata-Menchaca, J Sabater-Riera, M Estruch, E Boza, F Sbraga, J Toscana-Fernández, E Bruguera-Pellicer, J Ordoñez-Llanos, X L Pérez-Fernández, P Cavaleiro, A Tralhão, M Arrigo, J-P Lopes, M Lebrun, B Cholley, J L PerezVela, H MarinMateos, J J Jimenez Rivera, M A Alcala Llorente, B Gonzalez De Marcos, F J Gonzalez Fernandez, C Garcia Laborda, D Fernandez Zamora, J C Lopez Delgado, C Imperiali, D Berbel-Franco, M Dastis, G Moreno-Gonzalez, J Perez-Sanchez, I Romera-Peregrina, R Abellan-Lencina, A Martinez-Pascual, V Fuentes-Mila, M Gonzalez-Romero, J Górka, K Górka, T Iwaniec, M Frołow, K Polok, J Fronczek, M Kózka, J Musiał, W Szczeklik, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, F Ampatzidou, M Sileli, G Kehagioglou, A Madesis, T Karaiskos, C Moursia, H Maleoglou, K Leleki, G Drossos, Z Uz, Y Ince, R Papatella, E Bulent, P Guerci, C Ince, B De Mol, V Vicka, D Gineityte, D Ringaitiene, I Norkiene, J Sipylaite, C Möller, C Fleischmann, D O Thomas-Rueddel, V Vlasakov, B Rochwerg, P Theurer, L Gattinoni, K Reinhart, C S Hartog, A González Pérez, J Zanabili Al Sibai, P Martinez Camblor, P Alvarez Fernandez, J M García Gala, J Silba Guisasola, G Muñiz Albaiceta, T Tamura, T Yatabe, I Miyajima, K Yamashita, M Yokoyama, F Ampatzidou, G Kehagioglou, E Dalampini, M Nastou, A Baddour, A Ignatiadis, T Asteri, G Drossos, K E Hathorn, S W Purtle, C M Horkan, F K Gibbons, K B Christopher, M V Viana, T A Tonietto, L A Gross, V L Costa, A L J Tavares, B O Lisboa, R B Moraes, S R Vieira, L V Viana, M J Azevedo, G D Ceniccola, R S F Pequeno, T P Holanda, V S Mendonça, W M C Araújo, L S F Carvalho, E Segaran, L Vickers, K Brinchmann, I Wignall, F Rubulotta, I De Brito-Ashurst, R Del Olmo, M J Esteban, C Vaquerizo, R Carreño, V Gálvez, G Kaminsky, B Nieto, M Fuentes, M A De la Torre, E Torres, A Alonso, C Velayos, T Saldaña, A Escribá, J Grip, R Kölegård, P Sundblad, O Rooyackers, Ben Naser, F Jaziri, A Ben Jazia, M Barghouth, O Hentati, W Skouri, M El Euch, M Mahfoudhi, S Turki, K Ben Abdelghni, Ben Abdallah, B N M Maha, J Cánovas, F Sotos, A López, M Lorente, A Burruezo, D Torres, K Polok, A Włudarczyk, J Górka, A Hałek, J Musiał, W Szczeklik, A Ben Jazia, F Jaziri, M Bargouth, M Bennasr, S Turki, K Ben Abdelghani, T Ben Abdallah, H J de Grooth, I L Geenen, J J Parienti, H M Oudemans-van Straaten, H P Shum, H S King, K C Chan, W W Yan, J Gonzalez Londoño, C Lorencio Cardenas, M Morales Pedrosa, C Murcia Gubianas, C Fuster Bertolin, N Vila Batllori, J M Sirvent, K Wykes, J Jack, P Morgan, A Mukhopadhyay, H Y Chan, Y Kowitlawakul, D Remani, C S F Leong, C J Henry, Z A Puthucheary, N Mendsaikhan, T Begzjav, G Lundeg, M Dünser, E D Valenzuela Espinoza, S P Welsh, M F Motta, E Guerra, M C L Zerpa, F Zechner, M Furche, F Berdaguer, P N Rubatto Birri, A Risso-Vazquez, A Dubin, F D Masevicius, D Greaney, A Magee, G Fitzpatrick, R G Lugo-Cob, L A Sánchez-Hurtado, P C Arvizu-Tachiquín, B C Tejeda-Huezo, A A Cano-Oviedo, J A Baltazar-Torres, M S Aydogan, T Togal, A Taha, H Z Chai, C Kam, S S Yang Razali, V Sivasamy, L Y Kuan, V Poulose, M A Lopez Morales, S Castro, T Pires, L Melão, A Krystopchuk, I Pereira, C Granja, L U Taniguchi, E M C Pires, J M Vieira, L C P Azevedo
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://read.qxmd.com/read/27537778/clinical-evaluation-of-heart-failure-agreement-among-tests
#32
JOURNAL ARTICLE
Amit K Pandey, William F Penny, Valmik Bhargava, N Chin Lai, Ronghui Xu, H Kirk Hammond
Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT), and symptom evaluation. Although these approaches are useful in evaluating patients with heart failure, there are at times substantial mismatches between individual assessments. For example, ETT results are often discordant with EF, and patients with minimal symptoms sometimes have surprisingly low EFs. To better define the relationship of these methods of assessment, we studied 56 patients with heart failure with reduced EF (HFrEF) who underwent measurement of ETT duration, EF by echocardiography, quantitative symptom evaluation, and LV peak dP/dt (rate of left ventricular pressure development and decline, measured invasively)...
2016: PloS One
https://read.qxmd.com/read/27437887/intracoronary-gene-transfer-of-adenylyl-cyclase-6-in-patients-with-heart-failure-a-randomized-clinical-trial
#33
RANDOMIZED CONTROLLED TRIAL
H Kirk Hammond, William F Penny, Jay H Traverse, Timothy D Henry, Matthew W Watkins, Clyde W Yancy, Ranya N Sweis, Eric D Adler, Amit N Patel, David R Murray, Robert S Ross, Valmik Bhargava, Alan Maisel, Denise D Barnard, N Chin Lai, Nancy D Dalton, Martin L Lee, Sanjiv M Narayan, Daniel G Blanchard, Mei Hua Gao
IMPORTANCE: Gene transfer has rarely been tested in randomized clinical trials. OBJECTIVE: To evaluate the safety and efficacy of intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 (Ad5.hAC6) in heart failure. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled, phase 2 clinical trial was conducted in US medical centers (randomization occurred from July 19, 2010, to October 30, 2014). Participants 18 to 80 years with symptomatic heart failure (ischemic and nonischemic) and an ejection fraction (EF) of 40% or less were screened; 86 individuals were enrolled, and 56 were randomized...
May 1, 2016: JAMA Cardiology
https://read.qxmd.com/read/25760560/intravenous-aav8-encoding-urocortin-2-increases-function-of-the-failing-heart-in-mice
#34
JOURNAL ARTICLE
N Chin Lai, Mei Hua Gao, Dimosthenis Giamouridis, Jorge Suarez, Atsushi Miyanohara, Jay Parikh, Stephen Hightower, Tracy Guo, Wolfgang Dillmann, Young-Chul Kim, Julieta Diaz-Juarez, H Kirk Hammond
Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. We previously showed that a single intravenous (IV) injection of AAV8.UCn2 increases plasma UCn2 and left ventricular (LV) systolic and diastolic function for at least 7 months in normal mice. Here we test the hypothesis that IV delivery of AAV8.UCn2 increases function of the failing heart...
June 2015: Human Gene Therapy
https://read.qxmd.com/read/25740935/drosophila-muller-f-elements-maintain-a-distinct-set-of-genomic-properties-over-40-million-years-of-evolution
#35
JOURNAL ARTICLE
Wilson Leung, Christopher D Shaffer, Laura K Reed, Sheryl T Smith, William Barshop, William Dirkes, Matthew Dothager, Paul Lee, Jeannette Wong, David Xiong, Han Yuan, James E J Bedard, Joshua F Machone, Seantay D Patterson, Amber L Price, Bryce A Turner, Srebrenka Robic, Erin K Luippold, Shannon R McCartha, Tezin A Walji, Chelsea A Walker, Kenneth Saville, Marita K Abrams, Andrew R Armstrong, William Armstrong, Robert J Bailey, Chelsea R Barberi, Lauren R Beck, Amanda L Blaker, Christopher E Blunden, Jordan P Brand, Ethan J Brock, Dana W Brooks, Marie Brown, Sarah C Butzler, Eric M Clark, Nicole B Clark, Ashley A Collins, Rebecca J Cotteleer, Peterson R Cullimore, Seth G Dawson, Carter T Docking, Sasha L Dorsett, Grace A Dougherty, Kaitlyn A Downey, Andrew P Drake, Erica K Earl, Trevor G Floyd, Joshua D Forsyth, Jonathan D Foust, Spencer L Franchi, James F Geary, Cynthia K Hanson, Taylor S Harding, Cameron B Harris, Jonathan M Heckman, Heather L Holderness, Nicole A Howey, Dontae A Jacobs, Elizabeth S Jewell, Maria Kaisler, Elizabeth A Karaska, James L Kehoe, Hannah C Koaches, Jessica Koehler, Dana Koenig, Alexander J Kujawski, Jordan E Kus, Jennifer A Lammers, Rachel R Leads, Emily C Leatherman, Rachel N Lippert, Gregory S Messenger, Adam T Morrow, Victoria Newcomb, Haley J Plasman, Stephanie J Potocny, Michelle K Powers, Rachel M Reem, Jonathan P Rennhack, Katherine R Reynolds, Lyndsey A Reynolds, Dong K Rhee, Allyson B Rivard, Adam J Ronk, Meghan B Rooney, Lainey S Rubin, Luke R Salbert, Rasleen K Saluja, Taylor Schauder, Allison R Schneiter, Robert W Schulz, Karl E Smith, Sarah Spencer, Bryant R Swanson, Melissa A Tache, Ashley A Tewilliager, Amanda K Tilot, Eve VanEck, Matthew M Villerot, Megan B Vylonis, David T Watson, Juliana A Wurzler, Lauren M Wysocki, Monica Yalamanchili, Matthew A Zaborowicz, Julia A Emerson, Carlos Ortiz, Frederic J Deuschle, Lauren A DiLorenzo, Katie L Goeller, Christopher R Macchi, Sarah E Muller, Brittany D Pasierb, Joseph E Sable, Jessica M Tucci, Marykathryn Tynon, David A Dunbar, Levent H Beken, Alaina C Conturso, Benjamin L Danner, Gabriella A DeMichele, Justin A Gonzales, Maureen S Hammond, Colleen V Kelley, Elisabeth A Kelly, Danielle Kulich, Catherine M Mageeney, Nikie L McCabe, Alyssa M Newman, Lindsay A Spaeder, Richard A Tumminello, Dennis Revie, Jonathon M Benson, Michael C Cristostomo, Paolo A DaSilva, Katherine S Harker, Jenifer N Jarrell, Luis A Jimenez, Brandon M Katz, William R Kennedy, Kimberly S Kolibas, Mark T LeBlanc, Trung T Nguyen, Daniel S Nicolas, Melissa D Patao, Shane M Patao, Bryan J Rupley, Bridget J Sessions, Jennifer A Weaver, Anya L Goodman, Erica L Alvendia, Shana M Baldassari, Ashley S Brown, Ian O Chase, Maida Chen, Scott Chiang, Avery B Cromwell, Ashley F Custer, Tia M DiTommaso, Jad El-Adaimi, Nora C Goscinski, Ryan A Grove, Nestor Gutierrez, Raechel S Harnoto, Heather Hedeen, Emily L Hong, Barbara L Hopkins, Vilma F Huerta, Colin Khoshabian, Kristin M LaForge, Cassidy T Lee, Benjamin M Lewis, Anniken M Lydon, Brian J Maniaci, Ryan D Mitchell, Elaine V Morlock, William M Morris, Priyanka Naik, Nicole C Olson, Jeannette M Osterloh, Marcos A Perez, Jonathan D Presley, Matt J Randazzo, Melanie K Regan, Franca G Rossi, Melanie A Smith, Eugenia A Soliterman, Ciani J Sparks, Danny L Tran, Tiffany Wan, Anne A Welker, Jeremy N Wong, Aparna Sreenivasan, Jim Youngblom, Andrew Adams, Justin Alldredge, Ashley Bryant, David Carranza, Alyssa Cifelli, Kevin Coulson, Calise Debow, Noelle Delacruz, Charlene Emerson, Cassandra Farrar, Don Foret, Edgar Garibay, John Gooch, Michelle Heslop, Sukhjit Kaur, Ambreen Khan, Van Kim, Travis Lamb, Peter Lindbeck, Gabi Lucas, Elizabeth Macias, Daniela Martiniuc, Lissett Mayorga, Joseph Medina, Nelson Membreno, Shady Messiah, Lacey Neufeld, San Francisco Nguyen, Zachary Nichols, George Odisho, Daymon Peterson, Laura Rodela, Priscilla Rodriguez, Vanessa Rodriguez, Jorge Ruiz, Will Sherrill, Valeria Silva, Jeri Sparks, Geeta Statton, Ashley Townsend, Isabel Valdez, Mary Waters, Kyle Westphal, Stacey Winkler, Joannee Zumkehr, Randall J DeJong, Arlene J Hoogewerf, Cheri M Ackerman, Isaac O Armistead, Lara Baatenburg, Matthew J Borr, Lindsay K Brouwer, Brandon J Burkhart, Kelsey T Bushhouse, Lejla Cesko, Tiffany Y Y Choi, Heather Cohen, Amanda M Damsteegt, Jess M Darusz, Cory M Dauphin, Yelena P Davis, Emily J Diekema, Melissa Drewry, Michelle E M Eisen, Hayley M Faber, Katherine J Faber, Elizabeth Feenstra, Isabella T Felzer-Kim, Brandy L Hammond, Jesse Hendriksma, Milton R Herrold, Julia A Hilbrands, Emily J Howell, Sarah A Jelgerhuis, Timothy R Jelsema, Benjamin K Johnson, Kelly K Jones, Anna Kim, Ross D Kooienga, Erika E Menyes, Eric A Nollet, Brittany E Plescher, Lindsay Rios, Jenny L Rose, Allison J Schepers, Geoff Scott, Joshua R Smith, Allison M Sterling, Jenna C Tenney, Chris Uitvlugt, Rachel E VanDyken, Marielle VanderVennen, Samantha Vue, Nighat P Kokan, Kwabea Agbley, Sampson K Boham, Daniel Broomfield, Kayla Chapman, Ali Dobbe, Ian Dobbe, William Harrington, Marwan Ibrahem, Andre Kennedy, Chad A Koplinsky, Cassandra Kubricky, Danielle Ladzekpo, Claire Pattison, Roman E Ramirez, Lucia Wande, Sarah Woehlke, Matthew Wawersik, Elizabeth Kiernan, Jeffrey S Thompson, Roxanne Banker, Justina R Bartling, Chinmoy I Bhatiya, Anna L Boudoures, Lena Christiansen, Daniel S Fosselman, Kristin M French, Ishwar S Gill, Jessen T Havill, Jaelyn L Johnson, Lauren J Keny, John M Kerber, Bethany M Klett, Christina N Kufel, Francis J May, Jonathan P Mecoli, Callie R Merry, Lauren R Meyer, Emily G Miller, Gregory J Mullen, Katherine C Palozola, Jacob J Pfeil, Jessica G Thomas, Evan M Verbofsky, Eric P Spana, Anant Agarwalla, Julia Chapman, Ben Chlebina, Insun Chong, I N Falk, John D Fitzgibbons, Harrison Friedman, Osagie Ighile, Andrew J Kim, Kristin A Knouse, Faith Kung, Danny Mammo, Chun Leung Ng, Vinayak S Nikam, Diana Norton, Philip Pham, Jessica W Polk, Shreya Prasad, Helen Rankin, Camille D Ratliff, Victoria Scala, Nicholas U Schwartz, Jessica A Shuen, Amy Xu, Thomas Q Xu, Yi Zhang, Anne G Rosenwald, Martin G Burg, Stephanie J Adams, Morgan Baker, Bobbi Botsford, Briana Brinkley, Carter Brown, Shadie Emiah, Erica Enoch, Chad Gier, Alyson Greenwell, Lindsay Hoogenboom, Jordan E Matthews, Mitchell McDonald, Amanda Mercer, Nicholaus Monsma, Kristine Ostby, Alen Ramic, Devon Shallman, Matthew Simon, Eric Spencer, Trisha Tomkins, Pete Wendland, Anna Wylie, Michael J Wolyniak, Gregory M Robertson, Samuel I Smith, Justin R DiAngelo, Eric D Sassu, Satish C Bhalla, Karim A Sharif, Tenzin Choeying, Jason S Macias, Fareed Sanusi, Karvyn Torchon, April E Bednarski, Consuelo J Alvarez, Kristen C Davis, Carrie A Dunham, Alaina J Grantham, Amber N Hare, Jennifer Schottler, Zackary W Scott, Gary A Kuleck, Nicole S Yu, Marian M Kaehler, Jacob Jipp, Paul J Overvoorde, Elizabeth Shoop, Olivia Cyrankowski, Betsy Hoover, Matt Kusner, Devry Lin, Tijana Martinov, Jonathan Misch, Garrett Salzman, Holly Schiedermayer, Michael Snavely, Stephanie Zarrasola, Susan Parrish, Atlee Baker, Alissa Beckett, Carissa Belella, Julie Bryant, Turner Conrad, Adam Fearnow, Carolina Gomez, Robert A Herbstsomer, Sarah Hirsch, Christen Johnson, Melissa Jones, Rita Kabaso, Eric Lemmon, Carolina Marques Dos Santos Vieira, Darryl McFarland, Christopher McLaughlin, Abbie Morgan, Sepo Musokotwane, William Neutzling, Jana Nietmann, Christina Paluskievicz, Jessica Penn, Emily Peoples, Caitlin Pozmanter, Emily Reed, Nichole Rigby, Lasse Schmidt, Micah Shelton, Rebecca Shuford, Tiara Tirasawasdichai, Blair Undem, Damian Urick, Kayla Vondy, Bryan Yarrington, Todd T Eckdahl, Jeffrey L Poet, Alica B Allen, John E Anderson, Jason M Barnett, Jordan S Baumgardner, Adam D Brown, Jordan E Carney, Ramiro A Chavez, Shelbi L Christgen, Jordan S Christie, Andrea N Clary, Michel A Conn, Kristen M Cooper, Matt J Crowley, Samuel T Crowley, Jennifer S Doty, Brian A Dow, Curtis R Edwards, Darcie D Elder, John P Fanning, Bridget M Janssen, Anthony K Lambright, Curtiss E Lane, Austin B Limle, Tammy Mazur, Marly R McCracken, Alexa M McDonough, Amy D Melton, Phillip J Minnick, Adam E Musick, William H Newhart, Joseph W Noynaert, Bradley J Ogden, Michael W Sandusky, Samantha M Schmuecker, Anna L Shipman, Anna L Smith, Kristen M Thomsen, Matthew R Unzicker, William B Vernon, Wesley W Winn, Dustin S Woyski, Xiao Zhu, Chunguang Du, Caitlin Ament, Soham Aso, Laura Simone Bisogno, Jason Caronna, Nadezhda Fefelova, Lenin Lopez, Lorraine Malkowitz, Jonathan Marra, Daniella Menillo, Ifeanyi Obiorah, Eric Nyabeta Onsarigo, Shekerah Primus, Mahdi Soos, Archana Tare, Ameer Zidan, Christopher J Jones, Todd Aronhalt, James M Bellush, Christa Burke, Steve DeFazio, Benjamin R Does, Todd D Johnson, Nicholas Keysock, Nelson H Knudsen, James Messler, Kevin Myirski, Jade Lea Rekai, Ryan Michael Rempe, Michael S Salgado, Erica Stagaard, Justin R Starcher, Andrew W Waggoner, Anastasia K Yemelyanova, Amy T Hark, Anne Bertolet, Cyrus E Kuschner, Kesley Parry, Michael Quach, Lindsey Shantzer, Mary E Shaw, Mary A Smith, Omolara Glenn, Portia Mason, Charlotte Williams, S Catherine Silver Key, Tyneshia C P Henry, Ashlee G Johnson, Jackie X White, Adam Haberman, Sam Asinof, Kelly Drumm, Trip Freeburg, Nadia Safa, Darrin Schultz, Yakov Shevin, Petros Svoronos, Tam Vuong, Jules Wellinghoff, Laura L M Hoopes, Kim M Chau, Alyssa Ward, E Gloria C Regisford, LaJerald Augustine, Brionna Davis-Reyes, Vivienne Echendu, Jasmine Hales, Sharon Ibarra, Lauriaun Johnson, Steven Ovu, John M Braverman, Thomas J Bahr, Nicole M Caesar, Christopher Campana, Daniel W Cassidy, Peter A Cognetti, Johnathan D English, Matthew C Fadus, Cameron N Fick, Philip J Freda, Bryan M Hennessy, Kelsey Hockenberger, Jennifer K Jones, Jessica E King, Christopher R Knob, Karen J Kraftmann, Linghui Li, Lena N Lupey, Carl J Minniti, Thomas F Minton, Joseph V Moran, Krishna Mudumbi, Elizabeth C Nordman, William J Puetz, Lauren M Robinson, Thomas J Rose, Edward P Sweeney, Ashley S Timko, Don W Paetkau, Heather L Eisler, Megan E Aldrup, Jessica M Bodenberg, Mara G Cole, Kelly M Deranek, Megan DeShetler, Rose M Dowd, Alexandra K Eckardt, Sharon C Ehret, Jessica Fese, Amanda D Garrett, Anna Kammrath, Michelle L Kappes, Morgan R Light, Anne C Meier, Allison O'Rouke, Mallory Perella, Kimberley Ramsey, Jennifer R Ramthun, Mary T Reilly, Deirdre Robinett, Nadine L Rossi, Mary Grace Schueler, Emma Shoemaker, Kristin M Starkey, Ashley Vetor, Abby Vrable, Vidya Chandrasekaran, Christopher Beck, Kristen R Hatfield, Douglas A Herrick, Christopher B Khoury, Charlotte Lea, Christopher A Louie, Shannon M Lowell, Thomas J Reynolds, Jeanine Schibler, Alexandra H Scoma, Maxwell T Smith-Gee, Sarah Tuberty, Christopher D Smith, Jane E Lopilato, Jeanette Hauke, Jennifer A Roecklein-Canfield, Maureen Corrielus, Hannah Gilman, Stephanie Intriago, Amanda Maffa, Sabya A Rauf, Katrina Thistle, Melissa Trieu, Jenifer Winters, Bib Yang, Charles R Hauser, Tariq Abusheikh, Yara Ashrawi, Pedro Benitez, Lauren R Boudreaux, Megan Bourland, Miranda Chavez, Samantha Cruz, GiNell Elliott, Jesse R Farek, Sarah Flohr, Amanda H Flores, Chelsey Friedrichs, Zach Fusco, Zane Goodwin, Eric Helmreich, John Kiley, John Mark Knepper, Christine Langner, Megan Martinez, Carlos Mendoza, Monal Naik, Andrea Ochoa, Nicolas Ragland, England Raimey, Sunil Rathore, Evangelina Reza, Griffin Sadovsky, Marie-Isabelle B Seydoux, Jonathan E Smith, Anna K Unruh, Vicente Velasquez, Matthew W Wolski, Yuying Gosser, Shubha Govind, Nicole Clarke-Medley, Leslie Guadron, Dawn Lau, Alvin Lu, Cheryl Mazzeo, Mariam Meghdari, Simon Ng, Brad Pamnani, Olivia Plante, Yuki Kwan Wa Shum, Roy Song, Diana E Johnson, Mai Abdelnabi, Alexi Archambault, Norma Chamma, Shailly Gaur, Deborah Hammett, Adrese Kandahari, Guzal Khayrullina, Sonali Kumar, Samantha Lawrence, Nigel Madden, Max Mandelbaum, Heather Milnthorp, Shiv Mohini, Roshni Patel, Sarah J Peacock, Emily Perling, Amber Quintana, Michael Rahimi, Kristen Ramirez, Rishi Singhal, Corinne Weeks, Tiffany Wong, Aubree T Gillis, Zachary D Moore, Christopher D Savell, Reece Watson, Stephanie F Mel, Arjun A Anilkumar, Paul Bilinski, Rostislav Castillo, Michael Closser, Nathalia M Cruz, Tiffany Dai, Giancarlo F Garbagnati, Lanor S Horton, Dongyeon Kim, Joyce H Lau, James Z Liu, Sandy D Mach, Thu A Phan, Yi Ren, Kenneth E Stapleton, Jean M Strelitz, Ray Sunjed, Joyce Stamm, Morgan C Anderson, Bethany Grace Bonifield, Daniel Coomes, Adam Dillman, Elaine J Durchholz, Antoinette E Fafara-Thompson, Meleah J Gross, Amber M Gygi, Lesley E Jackson, Amy Johnson, Zuzana Kocsisova, Joshua L Manghelli, Kylie McNeil, Michael Murillo, Kierstin L Naylor, Jessica Neely, Emmy E Ogawa, Ashley Rich, Anna Rogers, J Devin Spencer, Kristina M Stemler, Allison A Throm, Matt Van Camp, Katie Weihbrecht, T Aaron Wiles, Mallory A Williams, Matthew Williams, Kyle Zoll, Cheryl Bailey, Leming Zhou, Darla M Balthaser, Azita Bashiri, Mindy E Bower, Kayla A Florian, Nazanin Ghavam, Elizabeth S Greiner-Sosanko, Helmet Karim, Victor W Mullen, Carly E Pelchen, Paul M Yenerall, Jiayu Zhang, Michael R Rubin, Suzette M Arias-Mejias, Armando G Bermudez-Capo, Gabriela V Bernal-Vega, Mariela Colon-Vazquez, Arelys Flores-Vazquez, Mariela Gines-Rosario, Ivan G Llavona-Cartagena, Javier O Martinez-Rodriguez, Lionel Ortiz-Fuentes, Eliezer O Perez-Colomba, Joseph Perez-Otero, Elisandra Rivera, Luke J Rodriguez-Giron, Arnaldo J Santiago-Sanabria, Andrea M Senquiz-Gonzalez, Frank R Soto delValle, Dorianmarie Vargas-Franco, Karla I Velázquez-Soto, Joan D Zambrana-Burgos, Juan Carlos Martinez-Cruzado, Lillyann Asencio-Zayas, Kevin Babilonia-Figueroa, Francis D Beauchamp-Pérez, Juliana Belén-Rodríguez, Luciann Bracero-Quiñones, Andrea P Burgos-Bula, Xavier A Collado-Méndez, Luis R Colón-Cruz, Ana I Correa-Muller, Jonathan L Crooke-Rosado, José M Cruz-García, Marianna Defendini-Ávila, Francheska M Delgado-Peraza, Alex J Feliciano-Cancela, Valerie M Gónzalez-Pérez, Wilfried Guiblet, Aldo Heredia-Negrón, Jennifer Hernández-Muñiz, Lourdes N Irizarry-González, Ángel L Laboy-Corales, Gabriela A Llaurador-Caraballo, Frances Marín-Maldonado, Ulises Marrero-Llerena, Héctor A Martell-Martínez, Idaliz M Martínez-Traverso, Kiara N Medina-Ortega, Sonya G Méndez-Castellanos, Krizia C Menéndez-Serrano, Carol I Morales-Caraballo, Saryleine Ortiz-DeChoudens, Patricia Ortiz-Ortiz, Hendrick Pagán-Torres, Diana Pérez-Afanador, Enid M Quintana-Torres, Edwin G Ramírez-Aponte, Carolina Riascos-Cuero, Michelle S Rivera-Llovet, Ingrid T Rivera-Pagán, Ramón E Rivera-Vicéns, Fabiola Robles-Juarbe, Lorraine Rodríguez-Bonilla, Brian O Rodríguez-Echevarría, Priscila M Rodríguez-García, Abneris E Rodríguez-Laboy, Susana Rodríguez-Santiago, Michael L Rojas-Vargas, Eva N Rubio-Marrero, Albeliz Santiago-Colón, Jorge L Santiago-Ortiz, Carlos E Santos-Ramos, Joseline Serrano-González, Alina M Tamayo-Figueroa, Edna P Tascón-Peñaranda, José L Torres-Castillo, Nelson A Valentín-Feliciano, Yashira M Valentín-Feliciano, Nadyan M Vargas-Barreto, Miguel Vélez-Vázquez, Luis R Vilanova-Vélez, Cristina Zambrana-Echevarría, Christy MacKinnon, Hui-Min Chung, Chris Kay, Anthony Pinto, Olga R Kopp, Joshua Burkhardt, Chris Harward, Robert Allen, Pavan Bhat, Jimmy Hsiang-Chun Chang, York Chen, Christopher Chesley, Dara Cohn, David DuPuis, Michael Fasano, Nicholas Fazzio, Katherine Gavinski, Heran Gebreyesus, Thomas Giarla, Marcus Gostelow, Rachel Greenstein, Hashini Gunasinghe, Casey Hanson, Amanda Hay, Tao Jian He, Katie Homa, Ruth Howe, Jeff Howenstein, Henry Huang, Aaditya Khatri, Young Lu Kim, Olivia Knowles, Sarah Kong, Rebecca Krock, Matt Kroll, Julia Kuhn, Matthew Kwong, Brandon Lee, Ryan Lee, Kevin Levine, Yedda Li, Bo Liu, Lucy Liu, Max Liu, Adam Lousararian, Jimmy Ma, Allyson Mallya, Charlie Manchee, Joseph Marcus, Stephen McDaniel, Michelle L Miller, Jerome M Molleston, Cristina Montero Diez, Patrick Ng, Natalie Ngai, Hien Nguyen, Andrew Nylander, Jason Pollack, Suchita Rastogi, Himabindu Reddy, Nathaniel Regenold, Jon Sarezky, Michael Schultz, Jien Shim, Tara Skorupa, Kenneth Smith, Sarah J Spencer, Priya Srikanth, Gabriel Stancu, Andrew P Stein, Marshall Strother, Lisa Sudmeier, Mengyang Sun, Varun Sundaram, Noor Tazudeen, Alan Tseng, Albert Tzeng, Rohit Venkat, Sandeep Venkataram, Leah Waldman, Tracy Wang, Hao Yang, Jack Y Yu, Yin Zheng, Mary L Preuss, Angelica Garcia, Matt Juergens, Robert W Morris, Alexis A Nagengast, Julie Azarewicz, Thomas J Carr, Nicole Chichearo, Mike Colgan, Megan Donegan, Bob Gardner, Nik Kolba, Janice L Krumm, Stacey Lytle, Laurell MacMillian, Mary Miller, Andrew Montgomery, Alysha Moretti, Brittney Offenbacker, Mike Polen, John Toth, John Woytanowski, Lisa Kadlec, Justin Crawford, Mary L Spratt, Ashley L Adams, Brianna K Barnard, Martin N Cheramie, Anne M Eime, Kathryn L Golden, Allyson P Hawkins, Jessica E Hill, Jessica A Kampmeier, Cody D Kern, Emily E Magnuson, Ashley R Miller, Cody M Morrow, Julia C Peairs, Gentry L Pickett, Sarah A Popelka, Alexis J Scott, Emily J Teepe, Katie A TerMeer, Carmen A Watchinski, Lucas A Watson, Rachel E Weber, Kate A Woodard, Daron C Barnard, Isaac Appiah, Michelle M Giddens, Gerard P McNeil, Adeola Adebayo, Kate Bagaeva, Justina Chinwong, Chrystel Dol, Eunice George, Kirk Haltaufderhyde, Joanna Haye, Manpreet Kaur, Max Semon, Dmitri Serjanov, Anika Toorie, Christopher Wilson, Nicole C Riddle, Jeremy Buhler, Elaine R Mardis, Sarah C R Elgin
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%)...
March 4, 2015: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/24277577/adenylyl-cyclase-6-mediates-loading-induced-bone-adaptation-in-vivo
#36
JOURNAL ARTICLE
Kristen L Lee, David A Hoey, Milos Spasic, Tong Tang, H Kirk Hammond, Christopher R Jacobs
Primary cilia are single, nonmotile, antenna-like structures extending from the apical membrane of most mammalian cells. They may mediate mechanotransduction, the conversion of external mechanical stimuli into biochemical intracellular signals. Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enriched in primary cilia of MLO-Y4 osteocyte-like cells, may play a role in a primary cilium-dependent mechanism of osteocyte mechanotransduction in vitro. In this study, we determined whether AC6 deletion impairs loading-induced bone formation in vivo...
March 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/24147149/preserved-cardiac-function-despite-marked-impairment-of-camp-generation
#37
JOURNAL ARTICLE
Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
OBJECTIVES: So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+) using agents that do not affect cAMP. Although left ventricular (LV) function is tightly linked to adenylyl cyclase (AC) activity, the beneficial effects of AC may be independent of cAMP and instead stem from effects on Ca(2+) handling...
2013: PloS One
https://read.qxmd.com/read/24091324/integrins-protect-cardiomyocytes-from-ischemia-reperfusion-injury
#38
JOURNAL ARTICLE
Hideshi Okada, N Chin Lai, Yoshitaka Kawaraguchi, Peter Liao, Jeffrey Copps, Yasuo Sugano, Sunaho Okada-Maeda, Indroneal Banerjee, Jan M Schilling, Alexandre R Gingras, Elizabeth K Asfaw, Jorge Suarez, Seok-Min Kang, Guy A Perkins, Carol G Au, Sharon Israeli-Rosenberg, Ana Maria Manso, Zheng Liu, Derek J Milner, Stephen J Kaufman, Hemal H Patel, David M Roth, H Kirk Hammond, Susan S Taylor, Wolfgang H Dillmann, Joshua I Goldhaber, Robert S Ross
Ischemic damage is recognized to cause cardiomyocyte (CM) death and myocardial dysfunction, but the role of cell-matrix interactions and integrins in this process has not been extensively studied. Expression of α7β1D integrin, the dominant integrin in normal adult CMs, increases during ischemia/reperfusion (I/R), while deficiency of β1 integrins increases ischemic damage. We hypothesized that the forced overexpression of integrins on the CM would offer protection from I/R injury. Tg mice with CM-specific overexpression of integrin α7β1D exposed to I/R had a substantial reduction in infarct size compared with that of α5β1D-overexpressing mice and WT littermate controls...
October 2013: Journal of Clinical Investigation
https://read.qxmd.com/read/23931341/intravenous-adeno-associated-virus-serotype-8-encoding-urocortin-2-provides-sustained-augmentation-of-left-ventricular-function-in-mice
#39
JOURNAL ARTICLE
Mei Hua Gao, N Chin Lai, Atsushi Miyanohara, Jan M Schilling, Jorge Suarez, Tong Tang, Tracy Guo, Ruoying Tang, Jay Parikh, Dimosthenis Giamouridis, Wolfgang H Dillmann, Hemal H Patel, David M Roth, Nancy D Dalton, H Kirk Hammond
Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. Here we ask whether a single intravenous injection of adeno-associated virus type 8 encoding murine urocortin-2 (AAV8.UCn2) could provide long-term elevation in plasma UCn2 levels and increased left ventricular (LV) function. Normal mice received AAV8.UCn2 (5×10¹¹ genome copies, intravenous)...
September 2013: Human Gene Therapy
https://read.qxmd.com/read/23609114/adenylyl-cyclase-subtype-specific-compartmentalization-differential-regulation-of-l-type-ca2-current-in-ventricular-myocytes
#40
JOURNAL ARTICLE
Valeriy Timofeyev, Richard E Myers, Hyo Jeong Kim, Ryan L Woltz, Padmini Sirish, James P Heiserman, Ning Li, Anil Singapuri, Tong Tang, Vladimir Yarov-Yarovoy, Ebenezer N Yamoah, H Kirk Hammond, Nipavan Chiamvimonvat
RATIONALE: Adenylyl cyclase (AC) represents one of the principal molecules in the β-adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second messenger, cAMP. AC types 5 (ACV) and 6 (ACVI) are the 2 main isoforms in the heart. Although highly homologous in sequence, these 2 proteins play different roles during the development of heart failure. Caveolin-3 is a scaffolding protein, integrating many intracellular signaling molecules in specialized areas called caveolae...
June 7, 2013: Circulation Research
keyword
keyword
42389
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.