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Hammond Kirk

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https://www.readbyqxmd.com/read/27699250/one-time-injection-of-aav8-encoding-urocortin-2-provides-long-term-resolution-of-insulin-resistance
#1
Mei Hua Gao, Dimosthenis Giamouridis, N Chin Lai, Evelyn Walenta, Vivian Almeida Paschoal, Young Chul Kim, Atsushi Miyanohara, Tracy Guo, Min Liao, Li Liu, Zhen Tan, Theodore P Ciaraldi, Simon Schenk, Aditi Bhargava, Da Young Oh, H Kirk Hammond
Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal within weeks, an effect that lasted for months. Hyperinsulinemic-euglycemic clamps showed reduced plasma insulin, increased glucose disposal rates, and increased insulin sensitivity following UCn2 gene transfer...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27686460/esicm-lives-2016-part-two-milan-italy-1-5-october-2016
#2
S Sivakumar, F S Taccone, K A Desai, C Lazaridis, M Skarzynski, M Sekhon, W Henderson, D Griesdale, L Chapple, A Deane, L Williams, R Strickland, K Lange, D Heyland, M Chapman, M J Rowland, P Garry, J Westbrook, R Corkill, C A Antoniades, K T Pattinson, G Fatania, A J Strong, R B Myers, C Lazaridis, C M Jermaine, C S Robertson, C G Rusin, J Hofmeijer, L Sondag, M C Tjepkema-Cloostermans, A Beishuizen, F H Bosch, M J A M van Putten, L Carteron, C Patet, D Solari, M Oddo, M A Ali, C Dias, R Almeida, A Vaz-Ferreira, J Silva, E Monteiro, A Cerejo, A P Rocha, A A Elsayed, A M Abougabal, B N Beshey, K M Alzahaby, S Pozzebon, A Blandino Ortiz, S Cristallini, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, M Hravnak, K Yousef, Y Chang, E Crago, R M Friedlander, S A Abdelmonem, S A Tahon, T A Helmy, H S Meligy, F Puig, I Dunn-Siegrist, J Pugin, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, D S Tomar, M Shafi, R Harne, D P Arora, N Talwar, S Mazumdar, E E Papakrivou, D 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Santibañez, M Le Guen, J Moore, N Mason, M Windpassinger, O Plattner, E Mascha, D I Sessler, Outcomes Research, U Melia, J Fontanet, J P van den Berg, M M R F Struys, H E M Vereecke, E W Jensen, P J T Rood, F van de Schoor, K van Tertholen, P Pickkers, M van den Boogaard, Z J Beardow, H Redhead, K Paramasivam, T Numan, M van den Boogaard, A M Kamper, P Rood, L M Peelen, P M Zeman, A J Slooter, C E van Ewijk, G E Jacobs, A R J Girbes, S N Myatra, M M Harish, N R Prabu, S Siddiqui, A P Kulkarni, J V Divatia, L D Murbach, M A Leite, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, N Hernández-Sánchez, L A Sánchez-Hurtado, F J García-Guillen, S A Ñamendys-Silva, B Maghsoudi, M Emami, M B Khosravi, F Zand, H R Tabatabaie, M Masjedi, G Sabetiyan, A Mokri, J Troubleyn, M Diltoer, R Jacobs, D N Nguyen, E De Waele, J De Regt, P M Honoré, V Van Gorp, H D Spapen, R S Contreras, N D 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Liu, F Shen, J L Teboul, N Anguel, A Beurton, N Bezaz, C Richard, X Monnet, T Fossali, R Colombo, D Ottolina, M Rossetti, C Mazzucco, A Marchi, A Porta, E Catena, K H Tollisen, G Ø Andersen, F Heyerdahl, D Jacobsen, M C de Waard, A R J Girbes, M C O van IJzendoorn, H Buter, W P Kingma, G J Navis, E C Boerma, J Rulisek, M Balik, S Zacharov, H S Kim, S J Jeon, H Namgung, E Lee, E Lee, Y J Cho, Y J Lee, A Huang, L Cioccari, N Luethi, J Mårtensson, R Bellomo, M Forsberg, G Edman, J Höjer, S Forsberg, M T Chiquito Freile, F N Hidalgo, J A Martinez Molina, R Lecumberri, A Figuerola Rosselló, P Medrano Travieso, G Tuero Leon, J Gonzalez Sanchez, L Sahuquillo Frias, D Balsells Rosello, J A Garcia Verdejo, J A Noria Serrano, D Winterwerp, T van Galen, A Vazin, I Karimzade, A Zand, E Ozen, S Ekemen, A Akcan, E Sen, B Buyukkidan Yelken, N Kureshi, L Fenerty, G Thibault-Halman, M Erdogan, S Walling, R S Green, D B Clarke, P Briassoulis, K Kalimeris, A Ntzouvani, T Nomikos, K Papaparaskeva, E Politi, G Kostopanagiotou, K Crewdson, M Rehn, A Weaver, K Brohi, D Lockey, S Wright, K Thomas, C Baker, L Mansfield, V Stafford, C Wade, G Watson, A Bryant, T Chadwick, J Shen, J Wilkinson, J Furneval, A Henderson, K Hugill, P Howard, A Roy, S Bonner, S Baudouin, C Sánchez Ramírez, S Hípola Escalada, M A Hernández Viera, M Cabrera Santana, L Caipe Balcázar, N Sangil Monroy, F Artiles Campelo, C F Lübbe Vázquez, P Saavedra Santana, S Ruiz Santana, L Carteron, C Patet, H Quintard, D Solari, P Bouzat, M Oddo, T Wollersheim, J Malleike, K Haas, N Carbon, J Schneider, C Birchmeier, J Fielitz, S Spuler, S Weber-Carstens, L Enseñat, A Pérez-Madrigal, P Saludes, L Proença, G Gruartmoner, C Espinal, J Mesquida, W Huber, M Eckmann, F Elkmann, A Gruber, T Lahmer, U Mayr, A Herner, R Schellnegger, J Schneider, R M Schmid, W Ayoub, W Samy, A Esmat, A Battah, S Mukhtar, W Mongkolpun, D Orbegozo Cortés, C P R Cordeiro, J L Vincent, J Creteur, S Funcke, H Groesdonk, B Saugel, G Wagenpfeil, S Wagenpfeil, D A Reuter, M M Fernandez, R Fernandez, M Magret, A González-Castro, M T Bouza, M Ibañez, C García, B Balerdi, A Mas, V Arauzo, J M Añón, F Ruiz, J Ferreres, R Tomás, M Alabert, A I Tizón, S Altaba, N Llamas, E C Goligher, E Fan, M Herridge, S Vorona, M Sklar, M Dres, N Rittayamai, A Lanys, C Urrea, G Tomlinson, W D Reid, G D Rubenfeld, B P Kavanagh, L J Brochard, N D Ferguson, A Serpa Neto, M Gama de Abreu, P Pelosi, M J Schultz, C Guérin, L Papazian, J Reignier, L Ayzac, A Loundou, J M Forel, C Rolland-Debord, C Bureau, T Poitou, M Clavel, S Perbet, N Terzi, A Kouatchet, T Similowski, A Demoule, N Hunfeld, Z Trogrlic, S Ladage, R J Osse, B Koch, W Rietdijk, J Devlin, M van der Jagt, E Picetti, P Ceccarelli, F Mensi, L Malchiodi, S Risolo, I Rossi, M V Antonini, F Servadei, M L Caspani, A Roquilly, S Lasocki, P Seguin, T Geeraerts, P F Perrigault, C Dahyot-Fizelier, C Paugam-Burtz, F Cook, R Cinotti, D Demeure Dit Latte, P J Mahe, C Fortuit, F Feuillet, K Asehnoune, C Marzorati, S Spina, V Scaravilli, A Vargiolu, M Riva, C Giussani, E Sganzerla, G Citerio, S Barbadillo, F J González de Molina, F Álvarez-Lerma, A Rodríguez, T Zakharkina, I Martin-Loeches, S Matamoros, P Povoa, A Torres, J Kastelijn, J J Hofstra, M de Jong, M Schultz, P Sterk, A Artigas, L J Bos, A S Moreau, I Martin-Loeches, P Povoa, J Salluh, A Rodriguez, S Nseir, E de Jong, J A van Oers, A Beishuizen, A R J Girbes, M W N Nijsten, D W de Lange, D Bonvicini, D Labate, L Benacchio, A Olivieri, E Pizzirani, J C Lopez-Delgado, M Gonzalez-Romero, V Fuentes-Mila, D Berbel-Franco, I Romera-Peregrina, A Martinez-Pascual, J Perez-Sanchez, R Abellan-Lencina, R E Ávila-Espinoza, G Moreno-Gonzalez, F Sbraga, S Griffiths, M P W Grocott, B Creagh-Brown, J Doyle, P Wilkerson, Y Soon, S Huddart, M Dickinson, A Riga, A Zuleika, K Miyamoto, Y Kawazoe, T Morimoto, T Yamamoto, A Fuke, A Hashimoto, H Koami, S Beppu, Y Katayama, M Ito, Y Ohta, H Yamamura, S L Rygård, L B Holst, J Wetterslev, P I Johansson, A Perner, I W Soliman, D W de Lange, D van Dijk, J J M van Delden, O L Cremer, A J C Slooter, L M Peelen, D McWilliams, C Snelson, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, M Veronesi, A Lischinsky, F J L López, L Benito Mori, G Plotnikow, A Díaz, S Giannasi, R Hernandez, L Krzisnik, C Cecotti, L Viola, R Lopez, J P Sottile, G Benavent, E Estenssoro, C M Chen, C C Lai, K C Cheng, W Chou, K S Chan, L E Roeker, C M Horkan, F K Gibbons, K B Christopher, P J M Weijs, K M Mogensen, J D Rawn, M K Robinson, K B Christopher, Z Tang, C Qiu, B Ouyang, C Cai, X Guan, T Regueira, L Cea, S Juan Carlos, B Elisa, C Puebla, A Vargas, M K Poulsen, L P Thomsen, S Kjærgaard, S E Rees, D S Karbing, T Wollersheim, S Frank, M C Müller, N M Carbon, V Skrypnikov, P A Pickerodt, R Falk, A Mahlau, S Weber-Carstens, A Lee, R Inglis, R Morgan, G Barker, K Kamata, T Abe, D Saitoh, Y Tokuda, R S Green, M B Butler, M Erdogan, H Tae Hwa, L Jae Gil, R Hernández Vaquero, E Rodriguez-Ruiz, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, D O Thomas-Rüddel, D Schwarzkopf, C Fleischmann, K Reinhart, S Suwanpasu, Y Sattayasomboon, N M Filgueiras Filho, J C A Oliveira, C S Ballalai, C V De Lucia, G P Araponga, L N Veiga, C S Silva, M E Garrido, B B Ramos, E F Ricaldi, S S Gomes, L Gemmell, A MacKay, C Wright, R I Docking, P Doherty, E Black, P Stenhouse, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, T Yatabe, S Inoue, M Sakaguchi, M Egi, Y Ali Abdelhamid, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, M Hokka, M Egi, S Mizobuchi, P Kar, M Plummer, Y Ali Abdelhamid, E Giersch, M Summers, S Hatzinikolas, S Heller, M Chapman, K Jones, M Horowitz, A Deane, R Schweizer, M Jacquet-Lagreze, P Portran, S Junot, B Allaouchiche, J L Fellahi, P Guerci, B Ergin, A Kapucu, C Ince, L Cioccari, N Luethi, M Crisman, R Bellomo, J Mårtensson, C Righy Shinotsuka, D Fagnoul, A Brasseur, D Orbegozo, J L Vincent, J C Preiser, J C Preiser, O Lheureux, A Thooft, S Brimioulle, J L Vincent, H Iwasaka, S Tahara, M Nagamine, A Ichigatani, A Rugerio Cabrera, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, A A Tanaka Montoya, A Pedraza Montenegro, G A Gálvez Blanco, C M Coronado Robles, A Drolz, T Horvatits, K Roedl, K Rutter, S Kluge, G C Funk, B Schneeweiss, V Fuhrmann, G Sabetian, F Pooresmaeel, F Zand, S Ghaffaripour, A Farbod, H Tabei, L Taheri, R Anandanadesan, V Metaxa, C Teixeira, S M Pereira, P Hernández-Marrero, A S Carvalho, M Beckmann, C S Hartog, D Schwarzkopf, A Raadts, A Robertsen, R Førde, N O Skaga, E Helseth, S Honeybul, K Ho, P Martinez Lopez, M Nieto Gonzalez, P Nuevo Ortega, E Camara Sola, T Spasova, M V de la Torre-Prados, O Kopecky, K Rusinova, P Waldauf, Z Cepeplikova, M Balik, J Palamidessi Domínguez, P Matia Almudevar, S Alcántara Carmona, J J Rubio Muñoz, D Palacios Castañeda, A Naharro Abellán, P Rodríguez Villamizar, J Veganzones Ramos, L Pérez Pérez, A Pérez Lucendo, M Camós Ejarque, A Estella, V Lopez Camps, M C Martín, N Masnou, S Barbosa, A Varela, I Palma, L Cristina, E Nunes, I Pereira, G Campello, C Granja, R Pande, M Pandey, S Varghese, M Chanu, M J Van Dam, E W M T Ter Braak, A Estella, M Gracia, R Viciana, M Recuerda, L Perez Fontaiña, B Tharmalingam, F Kovari, L Rose, M Mcginlay, R Amin, K Burns, B Connolly, N Hart, P Jouvet, S Katz, D Leasa, C Mawdsley, D Mcauley, M Schultz, B Blackwood, S Denham, R Worrall, M Arshad, P Isherwood, A Khadjibaev, D Sabirov, A Rosstalnaya, F Parpibaev, V Sharipova, G A Galvez Blanco, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, M Shafi, D S Tomar, R Harne, D P Arora, N Talwar, S Mazumdar, Y S Cha, S J Lee, N Tyagi, R K Rajput, S Taneja, V K Singh, S C Sharma, S Mittal, B K Rao, J Ayachi, N Fraj, S Romdhani, A Khedher, K Meddeb, N Sma, A Azouzi, R Bouneb, I 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M A Alfaro, F Parrilla, A Meli, M Pellegrini, N Rodriguez, J M Goyeneche, I Morán, H Aguirre, J Mancebo, S J H Heines, U Strauch, D C J J Bergmans, P Blankman, A Shono, D Hasan, D Gommers, W Y Chung, K S Lee, Y J Jung, J H Park, S S Sheen, K J Park, R Worral, S Denham, P Isherwood, S E Rees, S Larraza, N Dey, S Spadaro, J B Brohus, R W Winding, C A Volta, D S Karbing, F Ampatzidou, A Vlachou, G Kehagioglou, T Karaiskos, A Madesis, C Mauromanolis, N Michail, G Drossos, N Saraj, S Rijkenberg, H M Feijen, H Endeman, A A J Donnelly, E Morgan, H Garrard, H Buckley, L Russell, N Haase, A Perner, C Goh, K Mouyis, C L N Woodward, J Halliday, G B Encina, J Ros, L Lagunes, J Tabernero, F Bosch, J Rello, D García Huertas, F Manzano, E Morente-Constantin, B Rivera-Ginés, M Colmenero-Ruiz, A Naharro Abellán, L Pérez Pérez, A Pérez Lucendo, P Matía Almudévar, J Palamidessi Domínguez, P Rodríguez Villamizar, J García Sanz, I Fernandez Simon, B Lobo Valbuena, S Alcantara Carmona, M Pais, S Ramalingam, C Díaz, L Fox, M Santafe, P Barba, M García, S Leal, M Pérez, M L Pérez Pérez, A Naharro Abellán, A Pérez Lucendo, P Matia Almudevar, J Palamidessi Domínguez, P Rodríguez Villamizar, J Veganzones, I Fernandez Simón, B Lobo Valbuena, N Martínez, S Alcántara Carmona, I Moors, D Mokart, F Pène, J Lambert, A Kouatchet, J Mayaux, F Vincent, M Nyunga, F Bruneel, L Laisne, A Rabbat, C Lebert, P Perez, M Chaize, A Renault, A P Meert, R Hamidfar, M Jourdain, M Darmon, B Schlemmer, S Chevret, V Lemiale, E Azoulay, D Benoit, D Martins-Branco, M Sousa, S Marum, M J Bouw, G Galstyan, P Makarova, E Parovichnikova, L Kuzmina, V Troitskaya, N Drize, E Gemdzhian, V Savchenko, H C Chao, E Kılıc, B Demiriz, M L Uygur, M Sürücü, K Cınar, A E Yıldırım, K Kiss, B Köves, V Csernus, Z Molnár, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, S Gaffney, E Black, R Docking, C Judge, T Drew, H Misran, R Munshi, L McGovern, M Coyle, L Dunne, E Deasy, P Lavin, A Fahy, D M Darcy, M Donnelly, N H Ismail, T Hall, K Wykes, J Jack, W C Ngu, P Morgan, J Ruiz-Ramos, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andrés, A Castellanos, C E Ijssennagger, S Ten Hoorn, A van Wijk, J M van den Broek, P R Tuinman, A M Elmenshawy, B D Hammond, G Gibbon, T Belcham, K Burton, L U Taniguchi, F J S Ramos, A K Momma, A P R Martins-Filho, J J Bartocci, M F D Lopes, M H Sad, C M Rodrigues, E M C Pires, J M Vieira, M A Leite, L D Murbach, E F Osaku, J Barreto, S T Duarte, S Taba, D Miglioranza, D P Gund, C F Lordani, C R L M Costa, S M Ogasawara, A C Jorge, P A D Duarte, S Spadaro, M Capuzzo, F Dalla Corte, S Terranova, G Scaramuzzo, A Fogagnolo, S Bertacchini, A Bellonzi, R Ragazzi, C A Volta, C Cruz, A Nunes, F Seabra Pereira, I Aragão, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, J Paratz, J Kenardy, T Comans, F Coyer, P Thomas, R Boots, N Pereira, A Vilas-Boas, E Gomes, C Dias, J Torres, D Carvalho, E Molinos, C Vales, R Araújo, C Cruz, A Nunes, F Seabra Pereira, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, L Karnatovskaia, K Philbrick, G Ognjen, M Clark, R Molina Montero, J Luján Varas, L Alcázar Sánchez-Elvira, C Pintado Delgado, P Villa Díaz, B Llorente Ruiz, A Pardo Guerrero, J A Cambronero Galache, R Jiménez, S Rebollo, O Alejandro, A Fernández, S Moreno, L Herrera, A Ojados, M Galindo, J Murcia, M Contreras, S Sánchez-Argente, Y Bonilla, M D Rodríguez, J M Allegue, Ö Cakin, H Parlak, H Kirca, F Mutlu, B Aydınlı, M Cengiz, A Ramazanoglu, E-J Jung, S-Y Oh, H Lee, N M Filgueiras Filho, E F Ricaldi, S S Gomes, B B Ramos, C V De Lucia, C S Ballalai, J C A Oliveira, G P Araponga, L N Veiga, C S Silva, M E Garrido, J Cebrián Domenech, A Pinos Montalvo, T Ciges Chornet, P Concha Martinez, M Piñol Ribas, R Gimeno Costa, A Castellanos Ortega, C Forbes, H Prescott, A Lal, F A Khan, E G Dela Pena, J S Dizon, P P P Perez, C M J Wong, M Muñoz Garach, O Moreno Romero, R Ramirez Puerta, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, M S Kalaiselvan, R L Siva Kumar, M K Renuka, A S Arun Kumar, S De Rosa, F Ferrari, S Carboni Checcacci, A Rigobello, M Joannidis, F Politi, A Pellizzari, R Bonato, A Fernandez-Carmona, I Macias-Guarasa, R Gutierrez-Rodriguez, P Martinez-Lopez, M A Diaz-Castellanos, A Fernandez-Carmona, M Arias-Diaz, E Aguilar-Alonso, I Macias-Guarasa, P Martinez-Lopez, M A Diaz-Castellanos, R N Nikandish, V Artemenko, A Budnyuk, G Li Bassi, T Senussi, F Idone, E Aguilera Xiol, C Travierso, C Chiurazzi, A Motos, R Amaro, Y Hua, L Fernández-Barat, O T Ranzani, Q Bobi, M Rigol, A Torres, A Youn, J Gyung Hwang, M Muñoz Garach, O Moreno Romero, M E Yuste Ossorio, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, C Teixeira, H Figueira, R Oliveira, A Mota, I Aragão, O Kamp, O Cruciger, M Aach, C Kaczmarek, C Waydhas, T A Schildhauer, U Hamsen, M Camprubí-Rimblas, L Chimenti, R Guillamat-Prats, T Lebouvier, J Bringué, J Tijero, M N Gómez, L Blanch, A Artigas, G Tagliabue, M Ji, J V Suneby Jagers, P A Easton, R B Souza, A M A Liberatore, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, J Y Hong, M H Shin, M S Park, A Pomprapa, P A Pickerodt, M B T Hofferberth, M Russ, W Braun, M Walter, R Francis, B Lachmann, S Leonhardt, I H J Koh, R B Souza, A M C R P F Martins, J C F Vieira, A M A Liberatore, A Landaverde-López, N A Canedo-Castillo, A Esquivel-Chávez, P C Arvizu-Tachiquín, L A Sánchez-Hurtado, J A Baltazar-Torres, V Cardoso, A Krystopchuk, S Castro, L Melão, S Firmino, A Marreiros, C Granja, S Almaziad, A Kubbara, W Barnett, R Nakity, W Alamoudi, R Altook, T Tarazi, M Fida, F Safi, R Assaly, A Santini, M Milesi, T Maraffi, P Pugni, D T Andreis, M Cavenago, L Gattinoni, A Protti, G Perchiazzi, J B Borges, S Bayat, L Porra, L Broche, M Pellegrini, G Scaramuzzo, G Hedenstierna, A Larsson, M Pellegrini, G Hedenstierna, A Roneus, M Segelsjö, M C Vestito, A Larsson, G Perchiazzi, E Gremo, A Nyberg, M Castegren, A Pikwer, T Yoshida, D Engelberts, G Otulakowski, B Katira, M Post, N D Ferguson, L Brochard, M B P Amato, B P Kavanagh, N Koch, W Huber, J Hoellthaler, S Mair, V Phillip, R M Schmid, A Beitz, V Baladrón, F J Redondo Calvo, D Padilla, P Villarejo, R Villazala, A S Yuste, N Bejarano, R J Steenstra, H Banierink, J Hof, I C van der Horst, M W Nijsten, M Hoekstra, K Roedl, F Sterz, T Horvatits, K Horvatits, A Drolz, H Herkner, V Fuhrmann, M Kott, K Zitta, B Brandt, C Schildhauer, G Elke, L Hummitzsch, I Frerichs, N Weiler, M Albrecht, L Rey González, D Cabestrero Alonso, A Blandino Ortiz, R de Pablo Sánchez, J Higuera Lucas, K Roedl, F Sterz, A Drolz, K Horvatits, T Horvatits, H Herkner, V Fuhrmann, T Horvatits, A Drolz, K Roedl, K Rutter, A Ferlitsch, G Fauler, M Trauner, V Fuhrmann, T Horvatits, S Pischke, L Fischer, F Thaiss, M Koch, K Bangert, V Fuhrmann, S Kluge, A W Lohse, B Nashan, M Sterneck, S Faenza, A Siniscalchi, E Pierucci, E Mancini, D Ricci, C Gemelli, A Cuoghi, S Magnani, M Atti, F Sotos, J Cánovas, A López, A Burruezo, D Torres, M E Herrera-Gutierrez, J Barrueco-Francioni, D Arias-Verdú, R Lozano-Saez, G Quesada-Garcia, G Seller-Pérez, A Figueiredo, Y Anzola, R Pereira, L Bento, D Arias-Verdú, M Lai, M Deiana, J Barrueco-Francioni, M E Herrera-Gutierrez, G Seller-Perez, K Vardas, S Ilia, A Sertedaki, E Charmadari, C A Stratakis, E Briassouli, D Goukos, K Psarra, E Botoula, S Tsagarakis, E Mageira, C Routsi, S Nanas, G Briassoulis, A Boscolo, D Bertini, E Campello, V Lucchetta, E Piasentini, C M Radu, L Manesso, P Simioni, C Ori, H Su, Y M Lam, K Willis, V Pullar, R P Hubner, J L Tsang, L García de Guadiana-Romualdo, S Rebollo-Acebes, P Esteban-Torrella, R Jiménez-Sánchez, E Jiménez-Santos, A Ortín-Freire, A Hernando-Holgado, M D Albaladejo-Otón, L Coelho, L Rabello, J Salluh, I Martin-Loeches, A Rodriguez, S Nseir, P Póvoa, E Varis, V Pettilä, M Poukkanen, S Jacob, S Karlsson, A Perner, J Takala, E Wilkman, O H M Lundberg, L Bergenzaun, J Rydén, M Rosenqvist, O Melander, M S Chew, E Rodriguez-Ruiz, R Hernández Vaquero, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, Y Kishihara, H Yasuda, S Rebollo, L García de Guadiana-Romualdo, R Jimenez, P Esteban Torrella, A Fernandez, S Sanchez, A Ortin, G Li Bassi, R Guillamat Prats, A Artigas, E Aguilera, D Marti, O T Ranzani, M Rigol, L Fernandez, M Ferrer, I Martin-Loeches, A Torres, V S Lanziotti, P Póvoa, L Pulcheri, M O Ribeiro, A P Barbosa, J R Lapa E Silva, M Soares, J I F Salluh, I Palacios Garcia, A Diaz Martin, M Gil Marqués, A Puppo Moreno, A Gutierrez Pizarraya, J Pachón Diaz, M Pachón Ibañez, Y Smani, M Mc Connell, L A Zhang, R S Parker, I Banerjee, G Clermont, E Norberg, J Oras, A Cuisinier, C Maufrais, J F Payen, S Nottin, G Walther, P Bouzat, S Arib, F Bilotta, R Badenes, F Rubulotta, S Mirek, I A Crippa, B Monfort, E Stazi, A Lozano Roig, J Creteur, F S Taccone, S Magnoni, M Marando, S Pifferi, V Conte, F Ortolano, M Carbonara, G Bertani, E Scola, M Cadioli, F Triulzi, A Colombo, N Stocchetti, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Guimillo, C Sanchís Piqueras, J Romero Guia, M García Simon, A Mesejo Arizmendi, A Carratalá, S El Maraghi, A Yehia, M Bakry, A Shoman, F N Backes, M M Bianchin, S R R Vieira, A de Souza, A N Backes, C Klein, M S Kalaiselvan, M K Renuka, A S Arunkumar, A Lozano, O Lheureux, R Badenes, J L Vincent, J Creteur, F S Taccone, C Gallaher, S Cattlin, S Gordon, J Picard, V Fontana, O Bond, L Nobile, J L Vincent, J Creteur, F S Taccone, S Mrozek, L Delamarre, F Capilla, T Al-Saati, O Fourcade, T Geeraerts, A M Dominguez-Berrot, M Gonzalez-Vaquero, M E Vallejo-Pascual, D Gupta, B D Ivory, M Chopra, J McCarthy, C L Felderhof, C MacNeil, F Rubulotta, P Waldauf, M Maggiorini, F Duska, R R L Fumis, J M Vieira Junior, G Amarante, A Skorko, S Sanders, J Aron, R J Kroll, C Redfearn, P Krishnan, J E Khalil, F Kovari, N Kongpolprom, V Gulia, E Lourenço, L Melão, C Duro, G Baptista, A Alves, B Arminda, M Rodrigues, A Marreiros, C Granja, J Hayward, F Baldwin, R Gray, P A Katinakis, M Stijf, M Ten Kleij, M Jansen-Frederiks, R Broek, M de Bruijne, P E Spronk, K Sinha, M Luney, K Palmer, L Keating, M Abu-Habsa, R Bahl, N Baskaralingam, A Ahmad, L Kanapeckaite, P Bhatti, S Glace, S Jeyabraba, H F Lewis, A Kostopoulos, M Raja, A West, A Ely, L M Turkoglu, P Zolfaghari, J P Baptista, M P Marques, P Martins, J Pimentel, D Gupta, Y C Su, S Villacres, M E Stone, A Parsikia, S Medar, K P O'Dea, J Porter, N Tirlapur, J M Jonathan, S Singh, M Takata, M Abu-Habsa, A Ahmad, E McWhirter, R Lyon, M L Hariz, E Azmi, J Alkhan, S Honeybul, V Movsisyan, S Petrikov, Z Marutyan, I Aliev, A Evdokimov, E Antonucci, T Merz, C Hartmann, P Pelosi, E Calzia, P Radermacher, B Nußbaum, C Hartmann, M Huber-Lang, M Gröger, P Radermacher, B Nußbaum, B Nußbaum, E Antonucci, E Calzia, P Pelosi, P Radermacher, C Hartmann, E Svoren-Jabalera, E E Davenport, P Humburg, J Knight, C J Hinds, I J Jun, W J Kim, E H Lee, G Besch, A Perrotti, M Puyraveau, L Carteron, M Baltres, E Samain, S Chocron, S Pili-Floury, E P Plata-Menchaca, J Sabater-Riera, M Estruch, E Boza, F Sbraga, J Toscana-Fernández, E Bruguera-Pellicer, J Ordoñez-Llanos, X L Pérez-Fernández, P Cavaleiro, A Tralhão, M Arrigo, J-P Lopes, M Lebrun, B Cholley, J L PerezVela, H MarinMateos, J J Jimenez Rivera, M A Alcala Llorente, B Gonzalez De Marcos, F J Gonzalez Fernandez, C Garcia Laborda, D Fernandez Zamora, J C Lopez Delgado, C Imperiali, D Berbel-Franco, M Dastis, G Moreno-Gonzalez, J Perez-Sanchez, I Romera-Peregrina, R Abellan-Lencina, A Martinez-Pascual, V Fuentes-Mila, M Gonzalez-Romero, J Górka, K Górka, T Iwaniec, M Frołow, K Polok, J Fronczek, M Kózka, J Musiał, W Szczeklik, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, F Ampatzidou, M Sileli, G Kehagioglou, A Madesis, T Karaiskos, C Moursia, H Maleoglou, K Leleki, G Drossos, Z Uz, Y Ince, R Papatella, E Bulent, P Guerci, C Ince, B De Mol, V Vicka, D Gineityte, D Ringaitiene, I Norkiene, J Sipylaite, C Möller, C Fleischmann, D O Thomas-Rueddel, V Vlasakov, B Rochwerg, P Theurer, L Gattinoni, K Reinhart, C S Hartog, A González Pérez, J Zanabili Al Sibai, P Martinez Camblor, P Alvarez Fernandez, J M García Gala, J Silba Guisasola, G Muñiz Albaiceta, T Tamura, T Yatabe, I Miyajima, K Yamashita, M Yokoyama, F Ampatzidou, G Kehagioglou, E Dalampini, M Nastou, A Baddour, A Ignatiadis, T Asteri, G Drossos, K E Hathorn, S W Purtle, C M Horkan, F K Gibbons, K B Christopher, M V Viana, T A Tonietto, L A Gross, V L Costa, A L J Tavares, B O Lisboa, R B Moraes, S R Vieira, L V Viana, M J Azevedo, G D Ceniccola, R S F Pequeno, T P Holanda, V S Mendonça, W M C Araújo, L S F Carvalho, E Segaran, L Vickers, K Brinchmann, I Wignall, F Rubulotta, I De Brito-Ashurst, R Del Olmo, M J Esteban, C Vaquerizo, R Carreño, V Gálvez, G Kaminsky, B Nieto, M Fuentes, M A De la Torre, E Torres, A Alonso, C Velayos, T Saldaña, A Escribá, J Grip, R Kölegård, P Sundblad, O Rooyackers, Ben Naser, F Jaziri, A Ben Jazia, M Barghouth, O Hentati, W Skouri, M El Euch, M Mahfoudhi, S Turki, K Ben Abdelghni, Ben Abdallah, B N M Maha, J Cánovas, F Sotos, A López, M Lorente, A Burruezo, D Torres, K Polok, A Włudarczyk, J Górka, A Hałek, J Musiał, W Szczeklik, A Ben Jazia, F Jaziri, M Bargouth, M Bennasr, S Turki, K Ben Abdelghani, T Ben Abdallah, H J de Grooth, I L Geenen, J J Parienti, H M Oudemans-van Straaten, H P Shum, H S King, K C Chan, W W Yan, J Gonzalez Londoño, C Lorencio Cardenas, M Morales Pedrosa, C Murcia Gubianas, C Fuster Bertolin, N Vila Batllori, J M Sirvent, K Wykes, J Jack, P Morgan, A Mukhopadhyay, H Y Chan, Y Kowitlawakul, D Remani, C S F Leong, C J Henry, Z A Puthucheary, N Mendsaikhan, T Begzjav, G Lundeg, M Dünser, E D Valenzuela Espinoza, S P Welsh, M F Motta, E Guerra, M C L Zerpa, F Zechner, M Furche, F Berdaguer, P N Rubatto Birri, A Risso-Vazquez, A Dubin, F D Masevicius, D Greaney, A Magee, G Fitzpatrick, R G Lugo-Cob, L A Sánchez-Hurtado, P C Arvizu-Tachiquín, B C Tejeda-Huezo, A A Cano-Oviedo, J A Baltazar-Torres, M S Aydogan, T Togal, A Taha, H Z Chai, C Kam, S S Yang Razali, V Sivasamy, L Y Kuan, V Poulose, M A Lopez Morales, S Castro, T Pires, L Melão, A Krystopchuk, I Pereira, C Granja, L U Taniguchi, E M C Pires, J M Vieira, L C P Azevedo
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27537778/clinical-evaluation-of-heart-failure-agreement-among-tests
#3
Amit K Pandey, William F Penny, Valmik Bhargava, N Chin Lai, Ronghui Xu, H Kirk Hammond
Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT), and symptom evaluation. Although these approaches are useful in evaluating patients with heart failure, there are at times substantial mismatches between individual assessments. For example, ETT results are often discordant with EF, and patients with minimal symptoms sometimes have surprisingly low EFs. To better define the relationship of these methods of assessment, we studied 56 patients with heart failure with reduced EF (HFrEF) who underwent measurement of ETT duration, EF by echocardiography, quantitative symptom evaluation, and LV peak dP/dt (rate of left ventricular pressure development and decline, measured invasively)...
2016: PloS One
https://www.readbyqxmd.com/read/27437887/intracoronary-gene-transfer-of-adenylyl-cyclase-6-in-patients-with-heart-failure-a-randomized-clinical-trial
#4
H Kirk Hammond, William F Penny, Jay H Traverse, Timothy D Henry, Matthew W Watkins, Clyde W Yancy, Ranya N Sweis, Eric D Adler, Amit N Patel, David R Murray, Robert S Ross, Valmik Bhargava, Alan Maisel, Denise D Barnard, N Chin Lai, Nancy D Dalton, Martin L Lee, Sanjiv M Narayan, Daniel G Blanchard, Mei Hua Gao
IMPORTANCE: Gene transfer has rarely been tested in randomized clinical trials. OBJECTIVE: To evaluate the safety and efficacy of intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 (Ad5.hAC6) in heart failure. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled, phase 2 clinical trial was conducted in US medical centers (randomization occurred from July 19, 2010, to October 30, 2014). Participants 18 to 80 years with symptomatic heart failure (ischemic and nonischemic) and an ejection fraction (EF) of 40% or less were screened; 86 individuals were enrolled, and 56 were randomized...
May 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/25760560/intravenous-aav8-encoding-urocortin-2-increases-function-of-the-failing-heart-in-mice
#5
N Chin Lai, Mei Hua Gao, Dimosthenis Giamouridis, Jorge Suarez, Atsushi Miyanohara, Jay Parikh, Stephen Hightower, Tracy Guo, Wolfgang Dillmann, Young-Chul Kim, Julieta Diaz-Juarez, H Kirk Hammond
Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. We previously showed that a single intravenous (IV) injection of AAV8.UCn2 increases plasma UCn2 and left ventricular (LV) systolic and diastolic function for at least 7 months in normal mice. Here we test the hypothesis that IV delivery of AAV8.UCn2 increases function of the failing heart...
June 2015: Human Gene Therapy
https://www.readbyqxmd.com/read/25740935/drosophila-muller-f-elements-maintain-a-distinct-set-of-genomic-properties-over-40-million-years-of-evolution
#6
Wilson Leung, Christopher D Shaffer, Laura K Reed, Sheryl T Smith, William Barshop, William Dirkes, Matthew Dothager, Paul Lee, Jeannette Wong, David Xiong, Han Yuan, James E J Bedard, Joshua F Machone, Seantay D Patterson, Amber L Price, Bryce A Turner, Srebrenka Robic, Erin K Luippold, Shannon R McCartha, Tezin A Walji, Chelsea A Walker, Kenneth Saville, Marita K Abrams, Andrew R Armstrong, William Armstrong, Robert J Bailey, Chelsea R Barberi, Lauren R Beck, Amanda L Blaker, Christopher E Blunden, Jordan P Brand, Ethan J Brock, Dana W Brooks, Marie Brown, Sarah C Butzler, Eric M Clark, Nicole B Clark, Ashley A Collins, Rebecca J Cotteleer, Peterson R Cullimore, Seth G Dawson, Carter T Docking, Sasha L Dorsett, Grace A Dougherty, Kaitlyn A Downey, Andrew P Drake, Erica K Earl, Trevor G Floyd, Joshua D Forsyth, Jonathan D Foust, Spencer L Franchi, James F Geary, Cynthia K Hanson, Taylor S Harding, Cameron B Harris, Jonathan M Heckman, Heather L Holderness, Nicole A Howey, Dontae A Jacobs, Elizabeth S Jewell, Maria Kaisler, Elizabeth A Karaska, James L Kehoe, Hannah C Koaches, Jessica Koehler, Dana Koenig, Alexander J Kujawski, Jordan E Kus, Jennifer A Lammers, Rachel R Leads, Emily C Leatherman, Rachel N Lippert, Gregory S Messenger, Adam T Morrow, Victoria Newcomb, Haley J Plasman, Stephanie J Potocny, Michelle K Powers, Rachel M Reem, Jonathan P Rennhack, Katherine R Reynolds, Lyndsey A Reynolds, Dong K Rhee, Allyson B Rivard, Adam J Ronk, Meghan B Rooney, Lainey S Rubin, Luke R Salbert, Rasleen K Saluja, Taylor Schauder, Allison R Schneiter, Robert W Schulz, Karl E Smith, Sarah Spencer, Bryant R Swanson, Melissa A Tache, Ashley A Tewilliager, Amanda K Tilot, Eve VanEck, Matthew M Villerot, Megan B Vylonis, David T Watson, Juliana A Wurzler, Lauren M Wysocki, Monica Yalamanchili, Matthew A Zaborowicz, Julia A Emerson, Carlos Ortiz, Frederic J Deuschle, Lauren A DiLorenzo, Katie L Goeller, Christopher R Macchi, Sarah E Muller, Brittany D Pasierb, Joseph E Sable, Jessica M Tucci, Marykathryn Tynon, David A Dunbar, Levent H Beken, Alaina C Conturso, Benjamin L Danner, Gabriella A DeMichele, Justin A Gonzales, Maureen S Hammond, Colleen V Kelley, Elisabeth A Kelly, Danielle Kulich, Catherine M Mageeney, Nikie L McCabe, Alyssa M Newman, Lindsay A Spaeder, Richard A Tumminello, Dennis Revie, Jonathon M Benson, Michael C Cristostomo, Paolo A DaSilva, Katherine S Harker, Jenifer N Jarrell, Luis A Jimenez, Brandon M Katz, William R Kennedy, Kimberly S Kolibas, Mark T LeBlanc, Trung T Nguyen, Daniel S Nicolas, Melissa D Patao, Shane M Patao, Bryan J Rupley, Bridget J Sessions, Jennifer A Weaver, Anya L Goodman, Erica L Alvendia, Shana M Baldassari, Ashley S Brown, Ian O Chase, Maida Chen, Scott Chiang, Avery B Cromwell, Ashley F Custer, Tia M DiTommaso, Jad El-Adaimi, Nora C Goscinski, Ryan A Grove, Nestor Gutierrez, Raechel S Harnoto, Heather Hedeen, Emily L Hong, Barbara L Hopkins, Vilma F Huerta, Colin Khoshabian, Kristin M LaForge, Cassidy T Lee, Benjamin M Lewis, Anniken M Lydon, Brian J Maniaci, Ryan D Mitchell, Elaine V Morlock, William M Morris, Priyanka Naik, Nicole C Olson, Jeannette M Osterloh, Marcos A Perez, Jonathan D Presley, Matt J Randazzo, Melanie K Regan, Franca G Rossi, Melanie A Smith, Eugenia A Soliterman, Ciani J Sparks, Danny L Tran, Tiffany Wan, Anne A Welker, Jeremy N Wong, Aparna Sreenivasan, Jim Youngblom, Andrew Adams, Justin Alldredge, Ashley Bryant, David Carranza, Alyssa Cifelli, Kevin Coulson, Calise Debow, Noelle Delacruz, Charlene Emerson, Cassandra Farrar, Don Foret, Edgar Garibay, John Gooch, Michelle Heslop, Sukhjit Kaur, Ambreen Khan, Van Kim, Travis Lamb, Peter Lindbeck, Gabi Lucas, Elizabeth Macias, Daniela Martiniuc, Lissett Mayorga, Joseph Medina, Nelson Membreno, Shady Messiah, Lacey Neufeld, San Francisco Nguyen, Zachary Nichols, George Odisho, Daymon Peterson, Laura Rodela, Priscilla Rodriguez, Vanessa Rodriguez, Jorge Ruiz, Will Sherrill, Valeria Silva, Jeri Sparks, Geeta Statton, Ashley Townsend, Isabel Valdez, Mary Waters, Kyle Westphal, Stacey Winkler, Joannee Zumkehr, Randall J DeJong, Arlene J Hoogewerf, Cheri M Ackerman, Isaac O Armistead, Lara Baatenburg, Matthew J Borr, Lindsay K Brouwer, Brandon J Burkhart, Kelsey T Bushhouse, Lejla Cesko, Tiffany Y Y Choi, Heather Cohen, Amanda M Damsteegt, Jess M Darusz, Cory M Dauphin, Yelena P Davis, Emily J Diekema, Melissa Drewry, Michelle E M Eisen, Hayley M Faber, Katherine J Faber, Elizabeth Feenstra, Isabella T Felzer-Kim, Brandy L Hammond, Jesse Hendriksma, Milton R Herrold, Julia A Hilbrands, Emily J Howell, Sarah A Jelgerhuis, Timothy R Jelsema, Benjamin K Johnson, Kelly K Jones, Anna Kim, Ross D Kooienga, Erika E Menyes, Eric A Nollet, Brittany E Plescher, Lindsay Rios, Jenny L Rose, Allison J Schepers, Geoff Scott, Joshua R Smith, Allison M Sterling, Jenna C Tenney, Chris Uitvlugt, Rachel E VanDyken, Marielle VanderVennen, Samantha Vue, Nighat P Kokan, Kwabea Agbley, Sampson K Boham, Daniel Broomfield, Kayla Chapman, Ali Dobbe, Ian Dobbe, William Harrington, Marwan Ibrahem, Andre Kennedy, Chad A Koplinsky, Cassandra Kubricky, Danielle Ladzekpo, Claire Pattison, Roman E Ramirez, Lucia Wande, Sarah Woehlke, Matthew Wawersik, Elizabeth Kiernan, Jeffrey S Thompson, Roxanne Banker, Justina R Bartling, Chinmoy I Bhatiya, Anna L Boudoures, Lena Christiansen, Daniel S Fosselman, Kristin M French, Ishwar S Gill, Jessen T Havill, Jaelyn L Johnson, Lauren J Keny, John M Kerber, Bethany M Klett, Christina N Kufel, Francis J May, Jonathan P Mecoli, Callie R Merry, Lauren R Meyer, Emily G Miller, Gregory J Mullen, Katherine C Palozola, Jacob J Pfeil, Jessica G Thomas, Evan M Verbofsky, Eric P Spana, Anant Agarwalla, Julia Chapman, Ben Chlebina, Insun Chong, I N Falk, John D Fitzgibbons, Harrison Friedman, Osagie Ighile, Andrew J Kim, Kristin A Knouse, Faith Kung, Danny Mammo, Chun Leung Ng, Vinayak S Nikam, Diana Norton, Philip Pham, Jessica W Polk, Shreya Prasad, Helen Rankin, Camille D Ratliff, Victoria Scala, Nicholas U Schwartz, Jessica A Shuen, Amy Xu, Thomas Q Xu, Yi Zhang, Anne G Rosenwald, Martin G Burg, Stephanie J Adams, Morgan Baker, Bobbi Botsford, Briana Brinkley, Carter Brown, Shadie Emiah, Erica Enoch, Chad Gier, Alyson Greenwell, Lindsay Hoogenboom, Jordan E Matthews, Mitchell McDonald, Amanda Mercer, Nicholaus Monsma, Kristine Ostby, Alen Ramic, Devon Shallman, Matthew Simon, Eric Spencer, Trisha Tomkins, Pete Wendland, Anna Wylie, Michael J Wolyniak, Gregory M Robertson, Samuel I Smith, Justin R DiAngelo, Eric D Sassu, Satish C Bhalla, Karim A Sharif, Tenzin Choeying, Jason S Macias, Fareed Sanusi, Karvyn Torchon, April E Bednarski, Consuelo J Alvarez, Kristen C Davis, Carrie A Dunham, Alaina J Grantham, Amber N Hare, Jennifer Schottler, Zackary W Scott, Gary A Kuleck, Nicole S Yu, Marian M Kaehler, Jacob Jipp, Paul J Overvoorde, Elizabeth Shoop, Olivia Cyrankowski, Betsy Hoover, Matt Kusner, Devry Lin, Tijana Martinov, Jonathan Misch, Garrett Salzman, Holly Schiedermayer, Michael Snavely, Stephanie Zarrasola, Susan Parrish, Atlee Baker, Alissa Beckett, Carissa Belella, Julie Bryant, Turner Conrad, Adam Fearnow, Carolina Gomez, Robert A Herbstsomer, Sarah Hirsch, Christen Johnson, Melissa Jones, Rita Kabaso, Eric Lemmon, Carolina Marques Dos Santos Vieira, Darryl McFarland, Christopher McLaughlin, Abbie Morgan, Sepo Musokotwane, William Neutzling, Jana Nietmann, Christina Paluskievicz, Jessica Penn, Emily Peoples, Caitlin Pozmanter, Emily Reed, Nichole Rigby, Lasse Schmidt, Micah Shelton, Rebecca Shuford, Tiara Tirasawasdichai, Blair Undem, Damian Urick, Kayla Vondy, Bryan Yarrington, Todd T Eckdahl, Jeffrey L Poet, Alica B Allen, John E Anderson, Jason M Barnett, Jordan S Baumgardner, Adam D Brown, Jordan E Carney, Ramiro A Chavez, Shelbi L Christgen, Jordan S Christie, Andrea N Clary, Michel A Conn, Kristen M Cooper, Matt J Crowley, Samuel T Crowley, Jennifer S Doty, Brian A Dow, Curtis R Edwards, Darcie D Elder, John P Fanning, Bridget M Janssen, Anthony K Lambright, Curtiss E Lane, Austin B Limle, Tammy Mazur, Marly R McCracken, Alexa M McDonough, Amy D Melton, Phillip J Minnick, Adam E Musick, William H Newhart, Joseph W Noynaert, Bradley J Ogden, Michael W Sandusky, Samantha M Schmuecker, Anna L Shipman, Anna L Smith, Kristen M Thomsen, Matthew R Unzicker, William B Vernon, Wesley W Winn, Dustin S Woyski, Xiao Zhu, Chunguang Du, Caitlin Ament, Soham Aso, Laura Simone Bisogno, Jason Caronna, Nadezhda Fefelova, Lenin Lopez, Lorraine Malkowitz, Jonathan Marra, Daniella Menillo, Ifeanyi Obiorah, Eric Nyabeta Onsarigo, Shekerah Primus, Mahdi Soos, Archana Tare, Ameer Zidan, Christopher J Jones, Todd Aronhalt, James M Bellush, Christa Burke, Steve DeFazio, Benjamin R Does, Todd D Johnson, Nicholas Keysock, Nelson H Knudsen, James Messler, Kevin Myirski, Jade Lea Rekai, Ryan Michael Rempe, Michael S Salgado, Erica Stagaard, Justin R Starcher, Andrew W Waggoner, Anastasia K Yemelyanova, Amy T Hark, Anne Bertolet, Cyrus E Kuschner, Kesley Parry, Michael Quach, Lindsey Shantzer, Mary E Shaw, Mary A Smith, Omolara Glenn, Portia Mason, Charlotte Williams, S Catherine Silver Key, Tyneshia C P Henry, Ashlee G Johnson, Jackie X White, Adam Haberman, Sam Asinof, Kelly Drumm, Trip Freeburg, Nadia Safa, Darrin Schultz, Yakov Shevin, Petros Svoronos, Tam Vuong, Jules Wellinghoff, Laura L M Hoopes, Kim M Chau, Alyssa Ward, E Gloria C Regisford, LaJerald Augustine, Brionna Davis-Reyes, Vivienne Echendu, Jasmine Hales, Sharon Ibarra, Lauriaun Johnson, Steven Ovu, John M Braverman, Thomas J Bahr, Nicole M Caesar, Christopher Campana, Daniel W Cassidy, Peter A Cognetti, Johnathan D English, Matthew C Fadus, Cameron N Fick, Philip J Freda, Bryan M Hennessy, Kelsey Hockenberger, Jennifer K Jones, Jessica E King, Christopher R Knob, Karen J Kraftmann, Linghui Li, Lena N Lupey, Carl J Minniti, Thomas F Minton, Joseph V Moran, Krishna Mudumbi, Elizabeth C Nordman, William J Puetz, Lauren M Robinson, Thomas J Rose, Edward P Sweeney, Ashley S Timko, Don W Paetkau, Heather L Eisler, Megan E Aldrup, Jessica M Bodenberg, Mara G Cole, Kelly M Deranek, Megan DeShetler, Rose M Dowd, Alexandra K Eckardt, Sharon C Ehret, Jessica Fese, Amanda D Garrett, Anna Kammrath, Michelle L Kappes, Morgan R Light, Anne C Meier, Allison O'Rouke, Mallory Perella, Kimberley Ramsey, Jennifer R Ramthun, Mary T Reilly, Deirdre Robinett, Nadine L Rossi, Mary Grace Schueler, Emma Shoemaker, Kristin M Starkey, Ashley Vetor, Abby Vrable, Vidya Chandrasekaran, Christopher Beck, Kristen R Hatfield, Douglas A Herrick, Christopher B Khoury, Charlotte Lea, Christopher A Louie, Shannon M Lowell, Thomas J Reynolds, Jeanine Schibler, Alexandra H Scoma, Maxwell T Smith-Gee, Sarah Tuberty, Christopher D Smith, Jane E Lopilato, Jeanette Hauke, Jennifer A Roecklein-Canfield, Maureen Corrielus, Hannah Gilman, Stephanie Intriago, Amanda Maffa, Sabya A Rauf, Katrina Thistle, Melissa Trieu, Jenifer Winters, Bib Yang, Charles R Hauser, Tariq Abusheikh, Yara Ashrawi, Pedro Benitez, Lauren R Boudreaux, Megan Bourland, Miranda Chavez, Samantha Cruz, GiNell Elliott, Jesse R Farek, Sarah Flohr, Amanda H Flores, Chelsey Friedrichs, Zach Fusco, Zane Goodwin, Eric Helmreich, John Kiley, John Mark Knepper, Christine Langner, Megan Martinez, Carlos Mendoza, Monal Naik, Andrea Ochoa, Nicolas Ragland, England Raimey, Sunil Rathore, Evangelina Reza, Griffin Sadovsky, Marie-Isabelle B Seydoux, Jonathan E Smith, Anna K Unruh, Vicente Velasquez, Matthew W Wolski, Yuying Gosser, Shubha Govind, Nicole Clarke-Medley, Leslie Guadron, Dawn Lau, Alvin Lu, Cheryl Mazzeo, Mariam Meghdari, Simon Ng, Brad Pamnani, Olivia Plante, Yuki Kwan Wa Shum, Roy Song, Diana E Johnson, Mai Abdelnabi, Alexi Archambault, Norma Chamma, Shailly Gaur, Deborah Hammett, Adrese Kandahari, Guzal Khayrullina, Sonali Kumar, Samantha Lawrence, Nigel Madden, Max Mandelbaum, Heather Milnthorp, Shiv Mohini, Roshni Patel, Sarah J Peacock, Emily Perling, Amber Quintana, Michael Rahimi, Kristen Ramirez, Rishi Singhal, Corinne Weeks, Tiffany Wong, Aubree T Gillis, Zachary D Moore, Christopher D Savell, Reece Watson, Stephanie F Mel, Arjun A Anilkumar, Paul Bilinski, Rostislav Castillo, Michael Closser, Nathalia M Cruz, Tiffany Dai, Giancarlo F Garbagnati, Lanor S Horton, Dongyeon Kim, Joyce H Lau, James Z Liu, Sandy D Mach, Thu A Phan, Yi Ren, Kenneth E Stapleton, Jean M Strelitz, Ray Sunjed, Joyce Stamm, Morgan C Anderson, Bethany Grace Bonifield, Daniel Coomes, Adam Dillman, Elaine J Durchholz, Antoinette E Fafara-Thompson, Meleah J Gross, Amber M Gygi, Lesley E Jackson, Amy Johnson, Zuzana Kocsisova, Joshua L Manghelli, Kylie McNeil, Michael Murillo, Kierstin L Naylor, Jessica Neely, Emmy E Ogawa, Ashley Rich, Anna Rogers, J Devin Spencer, Kristina M Stemler, Allison A Throm, Matt Van Camp, Katie Weihbrecht, T Aaron Wiles, Mallory A Williams, Matthew Williams, Kyle Zoll, Cheryl Bailey, Leming Zhou, Darla M Balthaser, Azita Bashiri, Mindy E Bower, Kayla A Florian, Nazanin Ghavam, Elizabeth S Greiner-Sosanko, Helmet Karim, Victor W Mullen, Carly E Pelchen, Paul M Yenerall, Jiayu Zhang, Michael R Rubin, Suzette M Arias-Mejias, Armando G Bermudez-Capo, Gabriela V Bernal-Vega, Mariela Colon-Vazquez, Arelys Flores-Vazquez, Mariela Gines-Rosario, Ivan G Llavona-Cartagena, Javier O Martinez-Rodriguez, Lionel Ortiz-Fuentes, Eliezer O Perez-Colomba, Joseph Perez-Otero, Elisandra Rivera, Luke J Rodriguez-Giron, Arnaldo J Santiago-Sanabria, Andrea M Senquiz-Gonzalez, Frank R Soto delValle, Dorianmarie Vargas-Franco, Karla I Velázquez-Soto, Joan D Zambrana-Burgos, Juan Carlos Martinez-Cruzado, Lillyann Asencio-Zayas, Kevin Babilonia-Figueroa, Francis D Beauchamp-Pérez, Juliana Belén-Rodríguez, Luciann Bracero-Quiñones, Andrea P Burgos-Bula, Xavier A Collado-Méndez, Luis R Colón-Cruz, Ana I Correa-Muller, Jonathan L Crooke-Rosado, José M Cruz-García, Marianna Defendini-Ávila, Francheska M Delgado-Peraza, Alex J Feliciano-Cancela, Valerie M Gónzalez-Pérez, Wilfried Guiblet, Aldo Heredia-Negrón, Jennifer Hernández-Muñiz, Lourdes N Irizarry-González, Ángel L Laboy-Corales, Gabriela A Llaurador-Caraballo, Frances Marín-Maldonado, Ulises Marrero-Llerena, Héctor A Martell-Martínez, Idaliz M Martínez-Traverso, Kiara N Medina-Ortega, Sonya G Méndez-Castellanos, Krizia C Menéndez-Serrano, Carol I Morales-Caraballo, Saryleine Ortiz-DeChoudens, Patricia Ortiz-Ortiz, Hendrick Pagán-Torres, Diana Pérez-Afanador, Enid M Quintana-Torres, Edwin G Ramírez-Aponte, Carolina Riascos-Cuero, Michelle S Rivera-Llovet, Ingrid T Rivera-Pagán, Ramón E Rivera-Vicéns, Fabiola Robles-Juarbe, Lorraine Rodríguez-Bonilla, Brian O Rodríguez-Echevarría, Priscila M Rodríguez-García, Abneris E Rodríguez-Laboy, Susana Rodríguez-Santiago, Michael L Rojas-Vargas, Eva N Rubio-Marrero, Albeliz Santiago-Colón, Jorge L Santiago-Ortiz, Carlos E Santos-Ramos, Joseline Serrano-González, Alina M Tamayo-Figueroa, Edna P Tascón-Peñaranda, José L Torres-Castillo, Nelson A Valentín-Feliciano, Yashira M Valentín-Feliciano, Nadyan M Vargas-Barreto, Miguel Vélez-Vázquez, Luis R Vilanova-Vélez, Cristina Zambrana-Echevarría, Christy MacKinnon, Hui-Min Chung, Chris Kay, Anthony Pinto, Olga R Kopp, Joshua Burkhardt, Chris Harward, Robert Allen, Pavan Bhat, Jimmy Hsiang-Chun Chang, York Chen, Christopher Chesley, Dara Cohn, David DuPuis, Michael Fasano, Nicholas Fazzio, Katherine Gavinski, Heran Gebreyesus, Thomas Giarla, Marcus Gostelow, Rachel Greenstein, Hashini Gunasinghe, Casey Hanson, Amanda Hay, Tao Jian He, Katie Homa, Ruth Howe, Jeff Howenstein, Henry Huang, Aaditya Khatri, Young Lu Kim, Olivia Knowles, Sarah Kong, Rebecca Krock, Matt Kroll, Julia Kuhn, Matthew Kwong, Brandon Lee, Ryan Lee, Kevin Levine, Yedda Li, Bo Liu, Lucy Liu, Max Liu, Adam Lousararian, Jimmy Ma, Allyson Mallya, Charlie Manchee, Joseph Marcus, Stephen McDaniel, Michelle L Miller, Jerome M Molleston, Cristina Montero Diez, Patrick Ng, Natalie Ngai, Hien Nguyen, Andrew Nylander, Jason Pollack, Suchita Rastogi, Himabindu Reddy, Nathaniel Regenold, Jon Sarezky, Michael Schultz, Jien Shim, Tara Skorupa, Kenneth Smith, Sarah J Spencer, Priya Srikanth, Gabriel Stancu, Andrew P Stein, Marshall Strother, Lisa Sudmeier, Mengyang Sun, Varun Sundaram, Noor Tazudeen, Alan Tseng, Albert Tzeng, Rohit Venkat, Sandeep Venkataram, Leah Waldman, Tracy Wang, Hao Yang, Jack Y Yu, Yin Zheng, Mary L Preuss, Angelica Garcia, Matt Juergens, Robert W Morris, Alexis A Nagengast, Julie Azarewicz, Thomas J Carr, Nicole Chichearo, Mike Colgan, Megan Donegan, Bob Gardner, Nik Kolba, Janice L Krumm, Stacey Lytle, Laurell MacMillian, Mary Miller, Andrew Montgomery, Alysha Moretti, Brittney Offenbacker, Mike Polen, John Toth, John Woytanowski, Lisa Kadlec, Justin Crawford, Mary L Spratt, Ashley L Adams, Brianna K Barnard, Martin N Cheramie, Anne M Eime, Kathryn L Golden, Allyson P Hawkins, Jessica E Hill, Jessica A Kampmeier, Cody D Kern, Emily E Magnuson, Ashley R Miller, Cody M Morrow, Julia C Peairs, Gentry L Pickett, Sarah A Popelka, Alexis J Scott, Emily J Teepe, Katie A TerMeer, Carmen A Watchinski, Lucas A Watson, Rachel E Weber, Kate A Woodard, Daron C Barnard, Isaac Appiah, Michelle M Giddens, Gerard P McNeil, Adeola Adebayo, Kate Bagaeva, Justina Chinwong, Chrystel Dol, Eunice George, Kirk Haltaufderhyde, Joanna Haye, Manpreet Kaur, Max Semon, Dmitri Serjanov, Anika Toorie, Christopher Wilson, Nicole C Riddle, Jeremy Buhler, Elaine R Mardis, Sarah C R Elgin
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%)...
March 4, 2015: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/24277577/adenylyl-cyclase-6-mediates-loading-induced-bone-adaptation-in-vivo
#7
Kristen L Lee, David A Hoey, Milos Spasic, Tong Tang, H Kirk Hammond, Christopher R Jacobs
Primary cilia are single, nonmotile, antenna-like structures extending from the apical membrane of most mammalian cells. They may mediate mechanotransduction, the conversion of external mechanical stimuli into biochemical intracellular signals. Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enriched in primary cilia of MLO-Y4 osteocyte-like cells, may play a role in a primary cilium-dependent mechanism of osteocyte mechanotransduction in vitro. In this study, we determined whether AC6 deletion impairs loading-induced bone formation in vivo...
March 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/24147149/preserved-cardiac-function-despite-marked-impairment-of-camp-generation
#8
Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
OBJECTIVES: So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+) using agents that do not affect cAMP. Although left ventricular (LV) function is tightly linked to adenylyl cyclase (AC) activity, the beneficial effects of AC may be independent of cAMP and instead stem from effects on Ca(2+) handling...
2013: PloS One
https://www.readbyqxmd.com/read/24091324/integrins-protect-cardiomyocytes-from-ischemia-reperfusion-injury
#9
Hideshi Okada, N Chin Lai, Yoshitaka Kawaraguchi, Peter Liao, Jeffrey Copps, Yasuo Sugano, Sunaho Okada-Maeda, Indroneal Banerjee, Jan M Schilling, Alexandre R Gingras, Elizabeth K Asfaw, Jorge Suarez, Seok-Min Kang, Guy A Perkins, Carol G Au, Sharon Israeli-Rosenberg, Ana Maria Manso, Zheng Liu, Derek J Milner, Stephen J Kaufman, Hemal H Patel, David M Roth, H Kirk Hammond, Susan S Taylor, Wolfgang H Dillmann, Joshua I Goldhaber, Robert S Ross
Ischemic damage is recognized to cause cardiomyocyte (CM) death and myocardial dysfunction, but the role of cell-matrix interactions and integrins in this process has not been extensively studied. Expression of α7β1D integrin, the dominant integrin in normal adult CMs, increases during ischemia/reperfusion (I/R), while deficiency of β1 integrins increases ischemic damage. We hypothesized that the forced overexpression of integrins on the CM would offer protection from I/R injury. Tg mice with CM-specific overexpression of integrin α7β1D exposed to I/R had a substantial reduction in infarct size compared with that of α5β1D-overexpressing mice and WT littermate controls...
October 2013: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/23931341/intravenous-adeno-associated-virus-serotype-8-encoding-urocortin-2-provides-sustained-augmentation-of-left-ventricular-function-in-mice
#10
Mei Hua Gao, N Chin Lai, Atsushi Miyanohara, Jan M Schilling, Jorge Suarez, Tong Tang, Tracy Guo, Ruoying Tang, Jay Parikh, Dimosthenis Giamouridis, Wolfgang H Dillmann, Hemal H Patel, David M Roth, Nancy D Dalton, H Kirk Hammond
Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. Here we ask whether a single intravenous injection of adeno-associated virus type 8 encoding murine urocortin-2 (AAV8.UCn2) could provide long-term elevation in plasma UCn2 levels and increased left ventricular (LV) function. Normal mice received AAV8.UCn2 (5×10¹¹ genome copies, intravenous)...
September 2013: Human Gene Therapy
https://www.readbyqxmd.com/read/23609114/adenylyl-cyclase-subtype-specific-compartmentalization-differential-regulation-of-l-type-ca2-current-in-ventricular-myocytes
#11
Valeriy Timofeyev, Richard E Myers, Hyo Jeong Kim, Ryan L Woltz, Padmini Sirish, James P Heiserman, Ning Li, Anil Singapuri, Tong Tang, Vladimir Yarov-Yarovoy, Ebenezer N Yamoah, H Kirk Hammond, Nipavan Chiamvimonvat
RATIONALE: Adenylyl cyclase (AC) represents one of the principal molecules in the β-adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second messenger, cAMP. AC types 5 (ACV) and 6 (ACVI) are the 2 main isoforms in the heart. Although highly homologous in sequence, these 2 proteins play different roles during the development of heart failure. Caveolin-3 is a scaffolding protein, integrating many intracellular signaling molecules in specialized areas called caveolae...
June 7, 2013: Circulation Research
https://www.readbyqxmd.com/read/23587598/adenylyl-cyclase-6-deletion-increases-mortality-during-sustained-%C3%AE-adrenergic-receptor-stimulation
#12
Tong Tang, N Chin Lai, Adam T Wright, Mei Hua Gao, Paul Lee, Tracy Guo, Ruoying Tang, Andrew D McCulloch, H Kirk Hammond
Sustained β-adrenergic receptor stimulation is associated with cardiomyopathy, an affect thought to result from cAMP-associated cardiac injury. Using a murine line with adenylyl cyclase 6 gene deletion (AC6KO), we tested the hypothesis that AC6 deletion, by limiting cAMP production, would attenuate cardiomyopathy in the setting of sustained β-adrenergic receptor stimulation. During 7d isoproterenol infusion, there was unexpected higher mortality in AC6KO mice compared to wild type control mice (p<0.0001)...
July 2013: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/23261978/gene-transfer-for-congestive-heart-failure-update-2013
#13
REVIEW
Tong Tang, H Kirk Hammond
Congestive heart failure is a major cause of morbidity and mortality with increasing social and economic costs. There have been no new high impact therapeutic agents for this devastating disease for more than a decade. However, many pivotal regulators of cardiac function have been identified using cardiac-directed transgene expression and gene deletion in preclinical studies. Some of these increase function of the failing heart. Altering the expression of these pivotal regulators using gene transfer is now either being tested in clinical gene transfer trials, or soon will be...
April 2013: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/23123217/adenylyl-cyclase-6-enhances-nkcc2-expression-and-mediates-vasopressin-induced-phosphorylation-of-nkcc2-and-ncc
#14
Timo Rieg, Tong Tang, Shinichi Uchida, H Kirk Hammond, Robert A Fenton, Volker Vallon
Arginine vasopressin (AVP) affects kidney function via vasopressin V2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosine monophosphate formation. AVP/cyclic adenosine monophosphate enhance the phosphorylation of the Na-K-2Cl cotransporter (NKCC2) at serine residue 126 (pS126 NKCC2) and of the Na-Cl cotransporter (NCC) at threonine 58 (pT58 NCC). The isoform(s) of AC involved in these responses, however, were unknown. Phosphorylation of S126 NKCC2 and T58 NCC, induced by the V2 receptor agonist (1-desamino-8-D-arginine vasopressin) in wild-type mice, is lacking in knockout mice for AC isoform 6 (AC6)...
January 2013: American Journal of Pathology
https://www.readbyqxmd.com/read/23075106/comparison-of-adeno-associated-virus-serotypes-and-delivery-methods-for-cardiac-gene-transfer
#15
Hongfei Fang, N Chin Lai, Mei Hua Gao, Atsushi Miyanohara, David M Roth, Tong Tang, H Kirk Hammond
Abstract Cardiac gene transfer is a potentially useful strategy for cardiovascular diseases. The adeno-associated virus (AAV) is a common vector to obtain transgene expression in the heart. Initial studies conducted in rodents used indirect intracoronary delivery for cardiac gene transfer. More recently AAV vectors with so-called cardiac tropism have enabled significant cardiac transgene expression following intravenous injection. However, a direct comparison of intravenous vs intracoronary delivery with rigorous quantification of cardiac transgene expression has not been conducted...
October 17, 2012: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/22966786/comparison-of-adeno-associated-virus-serotypes-and-delivery-methods-for-cardiac-gene-transfer
#16
COMPARATIVE STUDY
Hongfei Fang, Ngai Chin Lai, Mei Hua Gao, Atsushi Miyanohara, David M Roth, Tong Tang, H Kirk Hammond
Cardiac gene transfer is a potentially useful strategy for cardiovascular diseases. The adeno-associated virus (AAV) is a common vector to obtain transgene expression in the heart. Initial studies conducted in rodents used indirect intracoronary delivery for cardiac gene transfer. More recently AAV vectors with so-called cardiac tropism have enabled significant cardiac transgene expression following intravenous injection. However, a direct comparison of intravenous versus intracoronary delivery with rigorous quantification of cardiac transgene expression has not been conducted...
August 2012: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/22534469/prospects-for-gene-transfer-for-clinical-heart-failure
#17
REVIEW
T Tang, M H Gao, H Kirk Hammond
Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congestive heart failure, paracrine-based gene transfer...
June 2012: Gene Therapy
https://www.readbyqxmd.com/read/22051336/reduced-collagen-deposition-in-infarcted-myocardium-facilitates-induced-pluripotent-stem-cell-engraftment-and-angiomyogenesis-for-improvement-of-left-ventricular-function
#18
Bo Dai, Wei Huang, Meifeng Xu, Ronald W Millard, Mei Hua Gao, H Kirk Hammond, Donald R Menick, Muhammad Ashraf, Yigang Wang
OBJECTIVES: The purpose of this study was to assess the effect of scar tissue composition on engraftment of progenitor cells into infarcted myocardium. BACKGROUND: Scar tissue formation after myocardial infarction creates a barrier that severely compromises tissue regeneration, limiting potential functional recovery. METHODS: In vitro: A tricell patch (Tri-P) was created from peritoneum seeded and cultured with induced pluripotent stem cell-derived cardiomyocytes, endothelial cells, and mouse embryonic fibroblasts...
November 8, 2011: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/22017392/improved-function-of-the-failing-rat-heart-by-regulated-expression-of-insulin-like-growth-factor-i-via-intramuscular-gene-transfer
#19
N Chin Lai, Tong Tang, Mei Hua Gao, Miho Saito, Atsushi Miyanohara, H Kirk Hammond
Current methods of gene transfer for heart disease include injection into heart muscle or intracoronary coronary delivery, approaches that typically provide limited expression and are cumbersome to apply. To circumvent these problems, we selected a transgene, insulin-like growth factor-I (IGF-I), which may, in theory, have favorable effects on heart function when secreted from a remote site. We examined the feasibility and efficacy of skeletal muscle injection of adeno-associated virus 5 encoding IGF-I under Tet regulation (AAV5...
March 2012: Human Gene Therapy
https://www.readbyqxmd.com/read/21982317/human-oxidation-specific-antibodies-reduce-foam-cell-formation-and-atherosclerosis-progression
#20
Sotirios Tsimikas, Atsushi Miyanohara, Karsten Hartvigsen, Esther Merki, Peter X Shaw, Meng-Yun Chou, Jennifer Pattison, Michael Torzewski, Janina Sollors, Theodore Friedmann, N Chin Lai, H Kirk Hammond, Godfrey S Getz, Catherine A Reardon, Andrew C Li, Carole L Banka, Joseph L Witztum
OBJECTIVES: We sought to assess the in vivo importance of scavenger receptor (SR)-mediated uptake of oxidized low-density lipoprotein (OxLDL) in atherogenesis and to test the efficacy of human antibody IK17-Fab or IK17 single-chain Fv fragment (IK17-scFv), which lacks immunologic properties of intact antibodies other than the ability to inhibit uptake of OxLDL by macrophages, to inhibit atherosclerosis. BACKGROUND: The unregulated uptake of OxLDL by macrophage SR contributes to foam cell formation, but the importance of this pathway in vivo is uncertain...
October 11, 2011: Journal of the American College of Cardiology
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