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https://www.readbyqxmd.com/read/29684802/bayesian-estimates-of-the-incidence-of-rare-cancers-in-europe
#1
Laura Botta, Riccardo Capocaccia, Annalisa Trama, Christian Herrmann, Diego Salmerón, Roberta De Angelis, Sandra Mallone, Ettore Bidoli, Rafael Marcos-Gragera, Dorota Dudek-Godeau, Gemma Gatta, Ramon Cleries
BACKGROUND: The RARECAREnet project has updated the estimates of the burden of the 198 rare cancers in each European country. Suspecting that scant data could affect the reliability of statistical analysis, we employed a Bayesian approach to estimate the incidence of these cancers. METHODS: We analyzed about 2,000,000 rare cancers diagnosed in 2000-2007 provided by 83 population-based cancer registries from 27 European countries. We considered European incidence rates (IRs), calculated over all the data available in RARECAREnet, as a valid a priori to merge with country-specific observed data...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684747/the-possible-dna-damage-induced-by-environmental-organic-compounds-the-case-of-nonylphenol
#2
REVIEW
Zahra Noorimotlagh, Seyyed Abbas Mirzaee, Mehdi Ahmadi, Neemat Jaafarzadeh, Fakher Rahim
Human impact on the environment leads to the release of many pollutants that produce artificial compounds, which can have harmful effects on the body's endocrine system; these are known as endocrine disruptors (EDs). Nonylphenol (NP) is a chemical compound with a nonyl group that is attached to a phenol ring. NP-induced H2 AX is a sensitive genotoxic biomarker for detecting possible DNA damage; it also causes male infertility and carcinogenesis. We attempt to comprehensively review all the available evidence about the different ways with descriptive mechanisms for explaining the possible DNA damage that is induced by NP...
April 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29684654/epidemiology-of-out-of-hospital-cardiac-arrest-a-french-national-incidence-and-mid-term-survival-rate-study
#3
Gérald Luc, Valentine Baert, Joséphine Escutnaire, Michael Genin, Christian Vilhelm, Christophe Di Pompéo, Carlos El Khoury, Nicolas Segal, Eric Wiel, Frédéric Adnet, Karim Tazarourte, Pierre-Yves Gueugniaud, Hervé Hubert
Out-of-hospital cardiac arrest (OHCA) is considered an important public health issue but its incidence has not been examined in France. The aim of this study is to define the incidence of OHCA in France and to compare this to other neighbouring countries. Data were extracted from the French OHCA registry. Only exhaustive centres during the period from January 1, 2013, to September 30, 2014 were included. All patients were included, regardless of their age and cause of OHCA. The participating centres covered about 10% of the French population...
April 20, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29684638/medication-related-osteonecrosis-of-the-jaw-a-survey-of-knowledge-attitudes-and-practices-among-dentists-in-the-principality-of-asturias-spain
#4
M Escobedo, L García-Consuegra, S Junquera, S Olay, G Ascani, L Junquera
INTRODUCTION: The objective of this study was to investigate the knowledge and capabilities of dentists and dental students in their last year of study in regard to risk factors of medication-related osteonecrosis of the jaw (MRONJ) in Spain. MATERIAL AND METHOD: We conducted a cross-sectional study consisting of a questionnaire survey in Asturias, Spain. The study was divided into three groups: dentists who worked for the public dental health care system (n=32), dentists who worked exclusively as private health care practitioners (n= 136), and dental students in their last year (year five) of study (n= 38)...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684634/interactive-electronic-decision-trees-for-the-integrated-primary-care-management-of-febrile-children-in-low-resource-settings-review-of-existing-tools
#5
REVIEW
Kristina Keitel, Valérie D'Acremont
BACKGROUND: The lack of effective, integrated diagnostic tools pose a major challenge to the primary care management of febrile childhood illnesses. These limitations are especially evident in low-resource settings and are often inappropriately compensated by antimicrobial over-prescription. Interactive electronic decision trees (IEDTs) have the potential to close these gaps: guiding antibiotic use and better identifying serious disease. AIMS: This narrative review summarizes existing IEDTs, to provide an overview of their degree of validation, as well as to identify gaps in current knowledge and prospects for future innovation...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684539/fewer-complications-after-uka-than-tka-in-patients-over-85-years-of-age-a-case-control-study
#6
Quentin Ode, Romain Gaillard, Cécile Batailler, Yannick Herry, Philippe Neyret, Elvire Servien, Sébastien Lustig
INTRODUCTION: Implanting a knee prosthesis in patients aged over 85 years is not without risk. Unicompartmental knee arthroplasty (UKA) is reputed to show lower morbidity and mortality than total knee arthroplasty (TKA). Elderly patients with isolated unicompartmental osteoarthritis without specific contraindications are thus good candidates for this procedure. The present retrospective case-control study compared complications rates in elderly patients receiving UKA versus TKA. The study hypothesis was that UKA incurs fewer complications, with equivalent functional results...
April 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29684315/sleep-disorders-in-patients-with-post-traumatic-stress-disorder
#7
REVIEW
Ali A El-Solh, Usman Riaz, Jasmine Roberts
A growing body of evidence supports a bidirectional relationship between post-traumatic stress disorder (PTSD) and sleep disturbances. Fragmented sleep induced by sleep-related breathing disorders, insomnia, and nightmares impacts recovery and treatment outcomes and worsens PTSD symptoms. Despite recent attention, management of these disorders has been unrewarding in the setting of PTSD. This review summarizes the evidence for empirically supported treatments of these sleep ailments as it relates to PTSD including psychotherapeutic and pharmacologic interventions...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684297/is-medical-marijuana-legalisation-possible-in-poland
#8
Dorota Rogowska-Szadkowska, Julia Strumiło, Sławomir Chlabicz
OBJECTIVES: In some countries of the world it is legal to use plant-based marijuana for therapeutic purposes. When we had learned that 7,000 petitioners (including doctors) signed the petition to enable access to marijuana for patients in the Czech Republic, we decided to examine the knowledge about marijuana's medical properties among Polish medical students. METHODS: Anonymous questionnaire study was conducted on a group of 181 of students of the last (sixth) year of medical school...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684230/effective-palliative-care-what-is-involved
#9
REVIEW
Mehak Swami, Amy Allen Case
It is important for oncologists who provide comprehensive cancer care to be familiar with the principles of primary palliative care and interdisciplinary team-based approaches to palliative care. Palliative care is a medical subspecialty that provides specialized care to individuals with serious illnesses, with a primary focus on providing symptom relief, pain management, and relief from psychosocial distress, regardless of diagnosis or prognosis. Ideally, palliative care is provided by a team of physicians, nurses, social workers, psychologists, and chaplains...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684225/primary-intraocular-malignant-rhabdoid-tumor-without-extrascleral-compromise
#10
Eva Ayala Barroso, Alejandra Tapia Bahamondes, Juan Carlos Sánchez España, Llúcia Alós, Ramón Medel Jiménez
Primary intraocular malignant rhabdoid tumor is classified as a malignant extrarenal rhabdoid tumor. It is extremely rare, highly aggressive, and, so far, only one case (in a newborn) has been described in the medical literature. The authors report a second case of primary intraocular malignant rhabdoid tumor, this time without extrascleral involvement and in a teenager, and describe its histological, immunohistochemical, and radiological characteristics along with clinical correlations. [J Pediatr Ophthalmol...
April 23, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29683987/case-report-linezolid-optic-neuropathy-and-proposed-evidenced-based-screening-recommendation
#11
Sean P Dempsey, Amy Sickman, William Scott Slagle
SIGNIFICANCE: This case illustrates a novel screening protocol for linezolid-induced toxic optic neuropathy. PURPOSE: To present a case report and analysis of linezolid-induced optic neuropathies in adult patients to develop screening recommendations. CASE REPORT: A case report of optic neuropathy from extended use of linezolid illustrates its potential effects on vision. We conduct a retrospective analysis of 39 reported cases to derive a recommended screening protocol for linezolid-induced toxic optic neuropathy in adult patients...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683948/hematopoietic-stem-cell-transplantation-from-unrelated-donors-in-2-cases-of-interleukin-10-receptor-deficiency-is-surgery-not-a-requirement
#12
Dilara F Kocacik Uygun, Vedat Uygun, Hayriye Daloğlu, Seda Öztürkmen, Gülsün Karasu, İsmail Reisli, Ersin Sayar, Hasan A Yüksekkaya, Erik-Oliver Glocker, Kaan Boztuğ, Akif Yeşilipek
Mutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas. Patients with infantile IBD often require several surgical interventions, including complete colectomy, and hematopoietic stem cell transplantation is currently the only known medical therapy. Traditionally, operative management has been preferred before stem cell transplantation because of the latter's increased susceptibility to procedural complications; however, surgical intervention could be delayed, and possibly reconsidered, because our 2 patients with infantile IBD demonstrated a rapid response to treatment via engraftment...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683875/characteristics-of-inpatient-units-associated-with-sustained-hand-hygiene-compliance
#13
Jonathan D Wolfe, Henry J Domenico, Gerald B Hickson, Deede Wang, Marilyn Dubree, Nancye Feistritzer, Nancy Wells, Thomas R Talbot
OBJECTIVES: Following institution of a hand hygiene (HH) program at an academic medical center, HH compliance increased from 58% to 92% for 3 years. Some inpatient units modeled early, sustained increases, and others exhibited protracted improvement rates. We examined the association between patterns of HH compliance improvement and unit characteristics. METHODS: Adult inpatient units (N = 35) were categorized into the following three tiers based on their pattern of HH compliance: early adopters, nonsustained and late adopters, and laggards...
April 20, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29683843/benefits-and-harms-of-lung-cancer-screening-in-hiv-infected-individuals-with-cd4-%C3%A2-500-a-simulation-study
#14
Chung Yin Kong, Keith Sigel, Steven D Criss, Deirdre F Sheehan, Matthew Triplette, Michael J Silverberg, Claudia I Henschke, Amy Justice, R Scott Braithwaite, Juan Wisnivesky, Kristina Crothers
OBJECTIVE: Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals. DESIGN: We modified an existing simulation model, the Lung Cancer Policy Model, for HIV-infected patients...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683740/clinical-use-of-closed-system-safety-peripheral-intravenous-cannulas
#15
Andrew Barton
Peripheral intravenous (IV) cannulas are the quickest and most effective way of gaining venous vascular access and administering IV therapy. Closed-system peripheral IV cannulas have been shown to be safe and more reliable than open, non-valved peripheral cannulas in clinical practice. This article introduces the Smiths Medical DeltaVen closed-system peripheral IV cannula and includes three case studies describing its use in clinical practice and associated patient outcomes.
April 26, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29683432/granular-cell-tumour-of-the-tongue-treated-by-radiofrequency-ablation
#16
Saverio Capodiferro, Angela Tempesta, Luisa Limongelli, Eugenio Maiorano, Gianfranco Favia
AIM: To report on a case of granular cell tumour occurring in the tongue surgically removed by surgical radiofrequency, with histological examination. MATERIAL OF STUDY: Discussion on the clinico-pathological characteristics of the granular cell tumour and the surgical treatment by surgical radiofrequency: the differential diagnosis is also discussed. RESULTS: Histological examination is mandatory for the final diagnosis. Surgical radiofrequency is an useful medical device to achieve good quality surgery with minimal post-operative course...
April 23, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29683199/comparison-of-superb-microvascular-imaging-with-color-flow-and-power-doppler-imaging-of-small-hepatocellular-carcinomas
#17
Theodore J Dubinsky, Jonathan Revels, Sherry Wang, Giuseppe Toia, Rachelle Sonneborn, Daniel S Hippe, Todd Erpelding
OBJECTIVES: The purpose of this study was to compare Superb Microvascular Imaging (SMI; Toshiba America Medical Systems, Tustin, CA) with conventional color flow Doppler (CFD) and power Doppler (PD) imaging in the liver to distinguish between malignant and benign liver neoplasms. METHODS: After Institutional Review Board approval (number 449984-ED), patients undergoing routine pre-radiofrequency ablation planning ultrasound examinations for suspected hepatocellular carcinomas (HCCs) of less than 2 cm in diameter between January 1, 2015, and July 1, 2016, were prospectively identified...
April 23, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29683035/is-peripherally-inserted-central-catheter-related-thrombosis-associated-with-abo-blood-group-a-case-control-pilot-study
#18
Raad A Haddad, Yanal Alnimer, Ahmed Abdalla, Carlos F Ríos-Bedoya, Ghassan Bachuwa
Peripherally inserted central catheter (PICC) use is associated with many complications including line-related thrombosis. Several studies and meta-analyses confirmed the increased risk to develop venous thromboembolism in non-O blood group individuals. Our pilot study aimed to examine whether PICC-related thrombosis is influenced by ABO blood group. We identified patients admitted to Hurley Medical Center between March 2012 and March 2016 who had PICC placed during their admission, had their ABO blood group identified in their medical record, and had upper extremity venous Doppler ultrasound performed on the same side of PICC...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29683008/first-trimester-combined-screening-biochemistry-in-detection-of-congenital-heart-defects
#19
Julia Alanen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Leskinen, Mika Gissler, Markku Ryynanen, Jaana Nevalainen
OBJECTIVE: To evaluate the performance of first trimester biochemical markers, pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (fβ-hCG), and nuchal translucency (NT) in detection of severe congenital heart defects (CHDs). METHODS: During the study period from 1 January 2008 to 31 December 2011, biochemical markers and NT were measured in 31,144 women as part of voluntary first trimester screening program for Down's syndrome in Northern Finland...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29682984/clinical-and-economic-benefits-of-advanced-microplegia-delivery-system-in-cardiac-surgery-evidence-from-250-hospitals
#20
Marc W Gerdisch, Scott Robinson, Guy David, Stephanie Makepeace, Michael P Ryan, Candace Gunnarsson
AIM: Determine the impact of a second generation microplegia delivery system (MPS2) compared with traditional cardioplegia. Materials &  methods: Multivariable difference-in-differences analysis using fixed effects was performed for each outcome: adverse event (AE) composite, total visit cost, medication cost, length of stay (LOS) and  intensive care unit (ICU) days. RESULTS: A 2.25% absolute risk reduction in AE composite was found with MPS2 compared with traditional cardioplegia, which equates to relative risk reduction of 5...
April 23, 2018: Journal of Comparative Effectiveness Research
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