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https://www.readbyqxmd.com/read/28709427/investigation-of-irradiated-volume-in-linac-based-brain-hypo-fractionated-stereotactic-radiotherapy
#1
Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss, Young Lee
BACKGROUND: Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to statistically parameterize irradiated volume independently of dose prescription, or margin to determine what spread in achievable irradiated volume one may expect for a given case. METHODS: We defined EXT as the total tissue within the external contour of the patient (including the target) and we defined BMP as the contour of the brain minus PTV...
July 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28699405/cut-off-values-of-the-japanese-orthopaedic-association-score-corresponding-to-constant-scores-for-evaluating-outcomes-in-rotator-cuff-tear
#2
Junichi Kawakami, Masafumi Gotoh, Koumei Matsuura, Kunichika Shin, Ikuhisa Fujito, Aya Tanaka, Saho Matsunaga, Takaki Imai, Takashi Nagamatsu, Kazuya Madokoro, Naoto Shiba
PURPOSE: To clarify the cut-off value of the Japanese Orthopaedic Association (JOA) score corresponding to rotator cuff tear outcome as evaluated by the Constant score. METHODS: The subjects were 230 patients with rotator cuff tear. The Constant and JOA scores on the first examination in our hospital were evaluated. After investigation of the correlation between the Constant and JOA scores, the cut-off JOA score was calculated, corresponding to excellent, good and fair outcomes as evaluated by the Constant score...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28695381/development-of-a-method-to-assess-the-ichthyotoxicity-of-the-harmful-marine-microalgae-karenia-spp-using-gill-cell-cultures-from-red-sea-bream-pagrus-major
#3
Nobuyuki Ohkubo, Yuji Tomaru, Haruo Yamaguchi, Saho Kitatsuji, Kazuhiko Mochida
The present study reports the development of a method to investigate ichthyotoxicity of harmful marine microalgae using cultured red sea bream (Pagrus major) gill cells. The cultured gill cells formed adherent 1-2 layers on the bottom of the culture plate and could tolerate seawater exposure for 4 h without significant alteration in cell survival. The microalgae Karenia mikimotoi, Karenia papilionacea, K. papilionacea phylotype-I, and Heterosigma akashiwo were cultured, then directly exposed to gill cells...
July 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28591818/yokukansan-for-the-treatment-of-preoperative-anxiety-and-postoperative-delirium-in-colorectal-cancer-patients-a-retrospective-study
#4
Saho Wada, Hironobu Inoguchi, Takatoshi Hirayama, Yutaka J Matsuoka, Yosuke Uchitomi, Hiroki Ochiai, Shunsuke Tsukamoto, Dai Shida, Yukihide Kanemitsu, Ken Shimizu
Background: Yokukansan (YKS), a Japanese traditional herbal medicine for neurosis and insomnia, is speculated to be useful for perioperative psychiatric symptoms in cancer patients, but there exists little empirical evidence. This study provides preliminary data about the efficacy, feasibility, and side effects of YKS for the treatment of preoperative anxiety and postoperative delirium in cancer patients. Methods: We retrospectively reviewed the medical records of colorectal cancer patients who took YKS for preoperative anxiety, evaluating the following: (1) patient characteristics, (2) feasibility of taking YKS, (3) changes in preoperative anxiety based on the Clinical Global Impression (CGI) scale and Edmonton Symptom Assessment System-revised (ESAS-r-anxiety), (4) incidence of postoperative delirium and (5) YKS-related side effects...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28532323/quantitative-regulation-of-histone-variant-h2a-z-during-cell-cycle-by-ubiquitin-proteasome-system-and-sumo-targeted-ubiquitin-ligases
#5
Daisuke Takahashi, Yuki Orihara, Saho Kitagawa, Masayuki Kusakabe, Takahiro Shintani, Yukako Oma, Masahiko Harata
Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.
May 22, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28498965/detection-of-zika-virus-in-a-traveller-from-vietnam-to-japan
#6
Yuichi Katanami, Satoshi Kutsuna, Satoshi Taniguchi, Shigeru Tajima, Saho Takaya, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Yasuyuki Kato, Norio Ohmagari
We report an imported case of Zika fever in a traveller from Vietnam. Zika virus (ZIKV) is currently widespread in Vietnam. Ongoing transmission of ZIKV has been reported in Southeast Asia, and with frequent travel between neighbouring regions, careful surveillance for imported cases is needed.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28418316/amoxicillin-and-ceftriaxone-as-treatment-alternatives-to-penicillin-for-maternal-syphilis
#7
Yuichi Katanami, Takehiro Hashimoto, Saho Takaya, Kei Yamamoto, Satoshi Kutsuna, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Norio Ohmagari
There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28380133/association-between-obstructive-sleep-apnea-and-myocardial-infarction-a-systematic-review
#8
Fernanda Porto, Yuri Saho Sakamoto, Cristina Salles
Obstructive sleep apnea (OSA) has been associated to cardiovascular risk factors. However, the association between OSA and cardiovascular disease is still controversial. The objective of the present study was to verify the association between OSA and myocardial infarction (MI). This is a systematic review of the literature performed through electronic data sources MEDLINE/PubMed, PubMed Central, Web of Science and BVS -Biblioteca Virtual em Saúde (Virtual Health Library). The descriptors used were: 'obstructive sleep apnea' AND 'polysomnography' AND 'myocardial infarction' AND 'adults NOT 'treatment...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28267573/owners-view-of-their-pets-emotions-intellect-and-mutual-relationship-cats-and-dogs-compared
#9
Minori Arahori, Hika Kuroshima, Yusuke Hori, Saho Takagi, Hitomi Chijiiwa, Kazuo Fujita
Companion animals have established special relationships with humans, as demonstrated by many studies describing their abilities and bonds to communicate with humans. In this questionnaire-based study, we explored owners' views of pets in terms of their emotional and intellectual functions and their relationship with owners, and compared the results between cat owners and dog owners. We found that although both types of owners most often regarded their pets as "family members," this tendency was weaker in cat owners...
March 4, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28065774/use-of-incidentally-encoded-memory-from-a-single-experience-in-cats
#10
Saho Takagi, Mana Tsuzuki, Hitomi Chijiiwa, Minori Arahori, Arii Watanabe, Atsuko Saito, Kazuo Fujita
We examined whether cats could retrieve and utilize incidentally encoded information from a single past event in a simple food-exploration task previously used for dogs (Fujita et al., 2012). In Experiment 1, cats were led to four open, baited containers and allowed to eat from two of them (Exposure phase). After a 15-min delay during which the cats were absent and all containers were replaced with empty ones, the cats were unexpectedly returned to the room and allowed to explore the containers (Test phase)...
January 5, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28034323/adenosquamous-carcinoma-in-the-biliary-tract-association-of-the-proliferative-ability-of-the-squamous-component-with-its-proportion-and-tumor-progression
#11
Sojun Hoshimoto, Sayuri Hoshi, Shoichi Hishinuma, Moriaki Tomikawa, Hirofumi Shirakawa, Iwao Ozawa, Saho Wakamatsu, Nobuo Hoshi, Kaoru Hirabayashi, Yoshiro Ogata
OBJECTIVES: The purpose of this study was to evaluate the association of the proliferative ability of squamous cell carcinoma (SCC) component with its proportion and tumor progression in adenosquamous carcinoma (ASC) in the biliary tract. METHODS: Nine patients with ASC in the biliary tract (four each in the gallbladder and the extrahepatic bile duct and one in the ampulla of Vater) who underwent surgical resection were retrospectively reviewed. RESULTS: The proportion of the SCC component in the primary sites ranged from 30% to 95%...
April 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27889828/physicians-practice-of-discussing-fertility-preservation-with-cancer-patients-and-the-associated-attitudes-and-barriers
#12
Emi Takeuchi, Masashi Kato, Saho Wada, Saran Yoshida, Chikako Shimizu, Yoko Miyoshi
PURPOSE: The aim of this study is to describe physicians' clinical practice of discussing fertility issues with cancer patients and determine the factors associated with such discussion. METHODS: In this cross-sectional study, a nationwide Internet survey was conducted among physicians who provided daily medical care to cancer patients at hospitals or clinics. Participants answered a questionnaire assessing characteristics, discussion practices, attitudes, and barriers regarding fertility preservation...
November 26, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27798149/menin-plays-a-critical-role-in-the-regulation-of-the-antigen-specific-cd8-t-cell-response-upon-listeria-infection
#13
Takeshi Yamada, Makoto Kanoh, Shogo Nabe, Toshiaki Yasuoka, Junpei Suzuki, Akira Matsumoto, Makoto Kuwahara, Saho Maruyama, Takuya Fujimoto, Ryo Sakisuka, Masaki Yasukawa, Masakatsu Yamashita
Menin, a tumor suppressor protein, is encoded by the MEN1 gene in humans. Certain germinal mutations of MEN1 induce an autosomal-dominant syndrome that is characterized by concurrent parathyroid adenomas and several other tumor types. Although menin is also expressed in hematopoietic lineages, its role in CD8(+) T cells remains unclear. We generated Menin(flox/flox) CD4-Cre (Menin-KO) mice by crossing Menin(flox/flox) mice with CD4-Cre transgenic (Tg) mice to determine the role of menin in CD8(+) T cells. Wild-type (WT) and Menin-KO mice were infected with Listeria monocytogenes expressing OVA to analyze the immune response of Ag-specific CD8(+) T cells...
October 19, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27697912/the-influence-of-olfactory-contexts-on-the-sequential-rating-of-odor-pleasantness
#14
Shiori Nakano, Saho Ayabe-Kanamura
When we sequentially evaluate the characteristics of sensory stimuli, our evaluation of a current stimulus is influenced by those preceding it. One such effect is called hedonic contrast, whereby stimuli are rated more negatively (negative contrast) or positively (positive contrast) if they are preceded by more or less pleasant stimuli. The present study investigated the characteristics of hedonic contrast for olfaction and compared these characteristics with those of a more oft-studied modality, vision. The results from two experiments indicated that both positive and negative contrasts occurred in the sequential rating of picture pleasantness, whereas only negative contrast occurred for olfactory ratings...
March 2017: Perception
https://www.readbyqxmd.com/read/27644879/osteoarthritis-derived-chondrocytes-are-a-potential-source-of-multipotent-progenitor-cells-for-cartilage-tissue-engineering
#15
Tomoyuki Oda, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Yohei Ono, Motoshige Nakashima, Shinya Ishizuka, Tetsuya Matsukawa, Satoshi Yamashita, Saho Tsuchiya, Naoki Ishiguro
The natural healing capacity of damaged articular cartilage is poor, rendering joint surface injuries a prime target for regenerative medicine. While autologous chondrocyte or mesenchymal stem cell (MSC) implantation can be applied to repair cartilage defects in young patients, no appropriate long-lasting treatment alternative is available for elderly patients with osteoarthritis (OA). Multipotent progenitor cells are reported to present in adult human articular cartilage, with a preponderance in OA cartilage...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27644554/correlation-of-3d-arterial-spin-labeling-and-multi-parametric-dynamic-susceptibility-contrast-perfusion-mri-in-brain-tumors
#16
Delgerdalai Khashbat Md, Takashi Abe Md, Mungunbagana Ganbold Md, Seiji Iwamoto Md, Naoto Uyama Md, Saho Irahara Md, Youichi Otomi Md PhD, Masafumi Harada Md PhD, Teruyoshi Kageji Md PhD, Shinji Nagahiro Md PhD
PURPOSE: Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. METHODS: Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI...
2016: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/27581382/bach2-batf-interactions-control-th2-type-immune-response-by-regulating-the-il-4-amplification-loop
#17
Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita
Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2-Batf complex antagonizes the recruitment of the Batf-Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore, we find that Bach2 regulates the Batf and Batf3 expressions via two distinct pathways. First, Bach2 suppresses the maintenance of the Batf and Batf3 expression through the inhibition of IL-4 production...
2016: Nature Communications
https://www.readbyqxmd.com/read/27470189/histone-deacetylase-inhibitors-stimulate-the-susceptibility-of-a549%C3%A2-cells-to-a-plasma-activated-medium-treatment
#18
Tetsuo Adachi, Ayame Kano, Saho Nonomura, Tetsuro Kamiya, Hirokazu Hara
The number of potential applications of non-thermal atmospheric pressure plasma (NTAPP) discharges in medicine, particularly in cancer therapy, has increased in recent years. NTAPP has been shown to affect cells not only by direct irradiation, but also by an indirect treatment with previously prepared plasma-activated medium (PAM). Histone deacetylase (HDAC) inhibitors have the potential to enhance susceptibility to anticancer drugs and radiation. The aim of the present study was to demonstrate the advantage of the combined application of PAM and HDAC inhibitors on A549 cancer cell survival and elucidate the underlying mechanisms...
September 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27462990/characteristics-of-haptic-peripersonal-spatial-representation-of-object-relations
#19
Ryo Wako, Saho Ayabe-Kanamura
Haptic perception of space is known to show characteristics that are different to actual space. The current study extends on this line of research, investigating whether systematic deviations are also observed in the formation of haptic spatial representations of object-to-object relations. We conducted a haptic spatial reproduction task analogous to the parallelity task with spatial layouts. Three magnets were positioned to form corners of an isosceles triangle and the task of the participant was to reproduce the right angle corner...
2016: PloS One
https://www.readbyqxmd.com/read/27405844/a-non-radioactive-assay-for-selenophosphate-synthetase-activity-using-recombinant-pyruvate-pyrophosphate-dikinase-from-thermus-thermophilus-hb8
#20
Saho Kamada, Takahiro Okugochi, Kaori Asano, Ryuta Tobe, Hisaaki Mihara, Michiko Nemoto, Kenji Inagaki, Takashi Tamura
Biosynthesis of selenocysteine-containing proteins requires monoselenophosphate, a selenium-donor intermediate generated by selenophosphate synthetase (Sephs). A non-radioactive assay was developed as an alternative to the standard [8-(14)C] AMP-quantifying assay. The product, AMP, was measured using a recombinant pyruvate pyrophosphate dikinase from Thermus thermophilus HB8. The KM and kcat for Sephs2-Sec60Cys were determined to be 26 μM and 0.352 min(-1), respectively.
October 2016: Bioscience, Biotechnology, and Biochemistry
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