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https://www.readbyqxmd.com/read/27889828/physicians-practice-of-discussing-fertility-preservation-with-cancer-patients-and-the-associated-attitudes-and-barriers
#1
Emi Takeuchi, Masashi Kato, Saho Wada, Saran Yoshida, Chikako Shimizu, Yoko Miyoshi
PURPOSE: The aim of this study is to describe physicians' clinical practice of discussing fertility issues with cancer patients and determine the factors associated with such discussion. METHODS: In this cross-sectional study, a nationwide Internet survey was conducted among physicians who provided daily medical care to cancer patients at hospitals or clinics. Participants answered a questionnaire assessing characteristics, discussion practices, attitudes, and barriers regarding fertility preservation...
November 26, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27798149/menin-plays-a-critical-role-in-the-regulation-of-the-antigen-specific-cd8-t-cell-response-upon-listeria-infection
#2
Takeshi Yamada, Makoto Kanoh, Shogo Nabe, Toshiaki Yasuoka, Junpei Suzuki, Akira Matsumoto, Makoto Kuwahara, Saho Maruyama, Takuya Fujimoto, Ryo Sakisuka, Masaki Yasukawa, Masakatsu Yamashita
Menin, a tumor suppressor protein, is encoded by the MEN1 gene in humans. Certain germinal mutations of MEN1 induce an autosomal-dominant syndrome that is characterized by concurrent parathyroid adenomas and several other tumor types. Although menin is also expressed in hematopoietic lineages, its role in CD8(+) T cells remains unclear. We generated Menin(flox/flox) CD4-Cre (Menin-KO) mice by crossing Menin(flox/flox) mice with CD4-Cre transgenic (Tg) mice to determine the role of menin in CD8(+) T cells. Wild-type (WT) and Menin-KO mice were infected with Listeria monocytogenes expressing OVA to analyze the immune response of Ag-specific CD8(+) T cells...
October 19, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27697912/the-influence-of-olfactory-contexts-on-the-sequential-rating-of-odor-pleasantness
#3
Shiori Nakano, Saho Ayabe-Kanamura
When we sequentially evaluate the characteristics of sensory stimuli, our evaluation of a current stimulus is influenced by those preceding it. One such effect is called hedonic contrast, whereby stimuli are rated more negatively (negative contrast) or positively (positive contrast) if they are preceded by more or less pleasant stimuli. The present study investigated the characteristics of hedonic contrast for olfaction and compared these characteristics with those of a more oft-studied modality, vision. The results from two experiments indicated that both positive and negative contrasts occurred in the sequential rating of picture pleasantness, whereas only negative contrast occurred for olfactory ratings...
October 3, 2016: Perception
https://www.readbyqxmd.com/read/27644879/osteoarthritis-derived-chondrocytes-are-a-potential-source-of-multipotent-progenitor-cells-for-cartilage-tissue-engineering
#4
Tomoyuki Oda, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Yohei Ono, Motoshige Nakashima, Shinya Ishizuka, Tetsuya Matsukawa, Satoshi Yamashita, Saho Tsuchiya, Naoki Ishiguro
The natural healing capacity of damaged articular cartilage is poor, rendering joint surface injuries a prime target for regenerative medicine. While autologous chondrocyte or mesenchymal stem cell (MSC) implantation can be applied to repair cartilage defects in young patients, no appropriate long-lasting treatment alternative is available for elderly patients with osteoarthritis (OA). Multipotent progenitor cells are reported to present in adult human articular cartilage, with a preponderance in OA cartilage...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27644554/correlation-of-3d-arterial-spin-labeling-and-multi-parametric-dynamic-susceptibility-contrast-perfusion-mri-in-brain-tumors
#5
Delgerdalai Khashbat Md, Takashi Abe Md, Mungunbagana Ganbold Md, Seiji Iwamoto Md, Naoto Uyama Md, Saho Irahara Md, Youichi Otomi Md PhD, Masafumi Harada Md PhD, Teruyoshi Kageji Md PhD, Shinji Nagahiro Md PhD
PURPOSE: Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. METHODS: Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI...
2016: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/27581382/bach2-batf-interactions-control-th2-type-immune-response-by-regulating-the-il-4-amplification-loop
#6
Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita
Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2-Batf complex antagonizes the recruitment of the Batf-Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore, we find that Bach2 regulates the Batf and Batf3 expressions via two distinct pathways. First, Bach2 suppresses the maintenance of the Batf and Batf3 expression through the inhibition of IL-4 production...
2016: Nature Communications
https://www.readbyqxmd.com/read/27470189/histone-deacetylase-inhibitors-stimulate-the-susceptibility-of-a549%C3%A2-cells-to-a-plasma-activated-medium-treatment
#7
Tetsuo Adachi, Ayame Kano, Saho Nonomura, Tetsuro Kamiya, Hirokazu Hara
The number of potential applications of non-thermal atmospheric pressure plasma (NTAPP) discharges in medicine, particularly in cancer therapy, has increased in recent years. NTAPP has been shown to affect cells not only by direct irradiation, but also by an indirect treatment with previously prepared plasma-activated medium (PAM). Histone deacetylase (HDAC) inhibitors have the potential to enhance susceptibility to anticancer drugs and radiation. The aim of the present study was to demonstrate the advantage of the combined application of PAM and HDAC inhibitors on A549 cancer cell survival and elucidate the underlying mechanisms...
September 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27462990/characteristics-of-haptic-peripersonal-spatial-representation-of-object-relations
#8
Ryo Wako, Saho Ayabe-Kanamura
Haptic perception of space is known to show characteristics that are different to actual space. The current study extends on this line of research, investigating whether systematic deviations are also observed in the formation of haptic spatial representations of object-to-object relations. We conducted a haptic spatial reproduction task analogous to the parallelity task with spatial layouts. Three magnets were positioned to form corners of an isosceles triangle and the task of the participant was to reproduce the right angle corner...
2016: PloS One
https://www.readbyqxmd.com/read/27405844/a-non-radioactive-assay-for-selenophosphate-synthetase-activity-using-recombinant-pyruvate-pyrophosphate-dikinase-from-thermus-thermophilus-hb8
#9
Saho Kamada, Takahiro Okugochi, Kaori Asano, Ryuta Tobe, Hisaaki Mihara, Michiko Nemoto, Kenji Inagaki, Takashi Tamura
Biosynthesis of selenocysteine-containing proteins requires monoselenophosphate, a selenium-donor intermediate generated by selenophosphate synthetase (Sephs). A non-radioactive assay was developed as an alternative to the standard [8-(14)C] AMP-quantifying assay. The product, AMP, was measured using a recombinant pyruvate pyrophosphate dikinase from Thermus thermophilus HB8. The KM and kcat for Sephs2-Sec60Cys were determined to be 26 μM and 0.352 min(-1), respectively.
October 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27334300/active-secretion-of-dimerized-s100a11-induced-by-the-peroxisome-in-mesothelioma-cells
#10
Satomi Saho, Hiroki Satoh, Eisaku Kondo, Yusuke Inoue, Akira Yamauchi, Hitoshi Murata, Rie Kinoshita, Ken-Ichi Yamamoto, Junichiro Futami, Endy Widya Putranto, I Made Winarsa Ruma, I Wayan Sumardika, Chen Youyi, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Shuta Tomida, Yoshihiko Sakaguchi, Ken Saito, Hidekazu Iioka, Nam-Ho Huh, Shinichi Toyooka, Masakiyo Sakaguchi
S100A11, a small Ca(2+) binding protein, acts extracellularly as a mediator of cancer progression. That raises the question of how a protein that lacks the classical secretory signal is able to be secreted outside cells without being damaged. Some insights into this question have been obtained, and there has been accumulating evidence indicating a pivotal role of a non-classical vesicle-mediated pathway using lysosomes or peroxisomes for the protein secretion. To obtain a more precise insight into the secretory mechanism of S100A11, we first screened representative cancer cells exhibiting significantly active secretion of S100A11...
June 22, 2016: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/27299293/there-s-no-ball-without-noise-cats-prediction-of-an-object-from-noise
#11
Saho Takagi, Minori Arahori, Hitomi Chijiiwa, Mana Tsuzuki, Yuya Hataji, Kazuo Fujita
We used an expectancy violation procedure to ask whether cats could use a causal rule to infer the presence of an unseen object on hearing the noise it made inside a container and predict its appearance when the container was turned over. We presented cats with either an object dropping out of an opaque container or no object dropping out (turning-over phase) after producing either a rattling sound by shaking the container with the object inside, or no sound (shaking phase). The cats were then allowed to freely explore the experimental environment (exploration phase)...
September 2016: Animal Cognition
https://www.readbyqxmd.com/read/27290345/blood-purification-therapy-prolongs-the-duration-of-intensive-care-unit-stay-to-14-days-or-more
#12
H Dohgomori, J Imamura, S Saho, K Kamimura, I Kukita
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27284976/the-transcriptional-repressor-gfi1-plays-a-critical-role-in-the-development-of-nkt1-and-nkt2-type-inkt-cells
#13
Toshiaki Yasuoka, Makoto Kuwahara, Takeshi Yamada, Saho Maruyama, Junpei Suzuki, Masaru Taniguchi, Masaki Yasukawa, Masakatsu Yamashita
Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear. We herein demonstrate a critical role of Gfi1 in regulating the development of iNKT cell subsets. In the thymus of T cell-specific Gfi1-deficient mice, iNKT cells normally developed up to stage 2, while the number of stage 3 NK1.1pos iNKT cells was significantly reduced. Furthermore, CD4pos iNKT cells were selectively reduced in the peripheral organs of T cell-specific Gfi1-deficient mice...
2016: PloS One
https://www.readbyqxmd.com/read/27256405/increased-18-f-fluorodeoxyglucose-accumulation-in-bilateral-adrenal-glands-of-the-patients-suffering-from-vasovagal-reaction-due-to-blood-vessel-puncture
#14
Yoichi Otomi, Takayoshi Shinya, Hideki Otsuka, Kaori Terazawa, Saho Irahara, Saki Nagase, Ayaka Takahashi, Michiko Kubo, Masafumi Harada
OBJECTIVE: The purpose of the study was to evaluate the hypothesis that patients having a vasovagal reaction (VVR) after blood vessel puncture show increased FDG accumulation in bilateral adrenal glands. METHODS: Over the past 8 years, 26 patients experienced a VVR after blood vessel puncture following intra-venous injection of FDG at our institution. Of the 26 patients, 16 underwent multiple-occasion FDG-PET/CT scans while suffering a VVR at only one examination...
August 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27255300/evaluation-of-the-impact-of-carotid-artery-bifurcation-angle-on-hemodynamics-by-use-of-computational-fluid-dynamics-a-simulation-and-volunteer-study
#15
Tatsunori Saho, Hideo Onishi
In this study, we evaluated the hemodynamics of carotid artery bifurcation with various geometries using simulated and volunteer models based on magnetic resonance imaging (MRI). Computational fluid dynamics (CFD) was analyzed by use of OpenFOAM. The velocity distribution, streamline, and wall shear stress (WSS) were evaluated in a simulated model with known bifurcation angles (30°, 40°, 50°, 60°, derived from patients' data) and in three-dimensional (3D) healthy volunteer models. Separated flow was observed at the outer side of the bifurcation, and large bifurcation models represented upstream transfer of the point...
July 2016: Radiological Physics and Technology
https://www.readbyqxmd.com/read/27066341/%C3%AE-%C3%AE-%C3%AE-tracking-filters-using-acceleration-measurements
#16
Kenshi Saho, Masao Masugi
BACKGROUND: Although real-time tracking of moving objects using a variety of sensor parameters is in great demand in monitoring systems, no studies have reported α-[Formula: see text]-[Formula: see text] tracking filters using simultaneous measurements including acceleration. In this report, we propose and analyze two α-[Formula: see text]-[Formula: see text] filters using acceleration measurements, namely, position-acceleration-measured (PAM) and position-velocity-acceleration-measured (PVAM) α-[Formula: see text]-[Formula: see text] filters...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27040630/oxaliplatin-alters-expression-of-t1r2-receptor-and-sensitivity-to-sweet-taste-in-rats
#17
Akihiro Ohishi, Kentaro Nishida, Yuri Yamanaka, Ai Miyata, Akiko Ikukawa, Miharu Yabu, Karin Miyamoto, Saho Bansho, Kazuki Nagasawa
As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we examined the molecular and behavioral characteristics of the oxaliplatin-induced taste disorder in rats. Oxaliplatin (4-16 mg/kg) was administered to Sprague-Dawley (SD) rats intraperitoneally for 2 d...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26964224/-study-on-the-color-determination-of-tomato-leaves-stressed-by-the-high-temperature-based-on-hyperspectral-imaging
#18
Chuan-qi Xie, Yong-ni Saho, Jun-feng Gao, Yong He
Determination of color values on tomato leaves stressed by the high temperature using hyperspectral imaging technique was studied in this paper. Hyperspectral images of sixty healthy and sixty unhealthy tomato leaves in the wavelengths of 380-1023 nm were acquired by the hyperspectral imaging system. Simultaneously, three color parameters (L*, a* and b*) were measured by a colorimeter. Reflectance of all pixels in the region of interest (ROI) was extracted from the corrected hyperspectral image. Partial Least Squares (PLS) models were established based on different preprocessing methods...
December 2015: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/26923255/mib1-modulates-dynamin-2-recruitment-via-snx18-to-promote-dll1-endocytosis-for-efficient-notch-signaling
#19
Makoto Okano, Hiromi Matsuo, Yuya Nishimura, Katsuto Hozumi, Saho Yoshioka, Ayako Tonoki, Motoyuki Itoh
Notch signaling regulates normal development and tissue homeostasis. Ligand endocytosis plays critical roles in Notch signaling activation. Endocytic proteins such as epsin and dynamin participate in Notch ligand activity by mediating Notch ligand endocytosis. The ubiquitin ligase Mib1 also plays essential roles in Notch signaling via Notch ligand ubiquitination. However, the molecular links between Mib1 and endocytic proteins have not been fully defined. Here, we show that Mib1 is involved in dynamin 2 recruitment to Dll1 and that Snx18, which interacts with dynamin 2, modestly regulates Dll1 endocytosis...
May 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/26865334/iron-stimulates-plasma-activated-medium-induced-a549-cell-injury
#20
Tetsuo Adachi, Saho Nonomura, Minori Horiba, Tasuku Hirayama, Tetsuro Kamiya, Hideko Nagasawa, Hirokazu Hara
Non-thermal atmospheric pressure plasma is applicable to living cells and has emerged as a novel technology for cancer therapy. Plasma has recently been shown to affect cells not only by direct irradiation, but also by indirect treatments with previously prepared plasma-activated medium (PAM). Iron is an indispensable element but is also potentially toxic because it generates the hydroxyl radical (•OH) in the presence of hydrogen peroxide (H2O2) via the Fenton reaction. The aim of the present study was to demonstrate the contribution of iron to PAM-induced A549 adenocarcinoma cell apoptosis...
2016: Scientific Reports
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