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Omar Qassid, Ahmed Ali, Khin Thway
Synovial sarcoma is a malignant mesenchymal tumor with variable epithelial differentiation, which is defined by the presence of a specific t(X;18)(p11.2;q11.2) chromosomal translocation that generates SS18-SSX fusion oncogenes. Synovial sarcoma typically arises within extremity deep soft tissue (particularly around large joints) of young adults, but has been shown to occur at almost any location. When it arises in more unusual sites, such as the abdomen, it can present a significant diagnostic challenge. We describe a case of intraabdominal monophasic synovial sarcoma that immunohistochemically showed strong expression of smooth muscle actin and calponin but only very scanty cytokeratin, and which showed morphologic and immunohistochemical overlap with other spindle cell neoplasms that can arise at this site, such as gastrointestinal stromal tumor and myofibrosarcoma...
September 2016: International Journal of Surgical Pathology
Na-Hye Myong, Jun-Won Min
BACKGROUND: Myofibroblastic sarcoma or myofibrosarcoma is a malignant tumor of myofibroblasts and known to develop rarely in the breast, but its underlying lesion and tumor cell origin have never been reported yet. CASE PRESENTATION: A 61-year-old female presented with a gradually growing breast mass with well-demarcated ovoid nodular shape. The tumor was histologically characterized by fascicular-growing spindle cell proliferation with large areas of hyalinized fibrosis and focally ductal epithelial remnants embedded in myxoid stroma, mimicking a fibroadenomatous lesion...
2016: Diagnostic Pathology
Miralem Pasic, Evgenij Potapov
We report on construction of a neo-left atrium (LA) with 2 bovine pericardial patches after in toto removal of a huge mediastinal tumor invading the heart and lung. The procedure was performed on the beating heart using normothermic cardiopulmonary bypass (CPB) without cardioplegic arrest. Treatment consisted of tumor removal necessitating left pneumonectomy, excision of the LA, resection of the mitral annulus, excision of the tumor from the left ventricle, and construction of a new LA using 2 bovine pericardial patches and a new mitral bioprosthesis...
December 2015: Annals of Thoracic Surgery
T S Korampalli, Bipin Mathew, N D Stafford
Malignant tumours of myofibroblasts are rare lesions. Post radiation sarcoma is a rare potential late sequel of ionizing radiation. We present the first case of myofibrosarcoma of the hypopharynx in a 67-year-old man, occurring 16 years after radiotherapy for laryngeal carcinoma.
2013: Journal of Surgical Case Reports
Stefan Hartmann, Grit Lessner, Thomas Mentzel, Alexander C Kübler, Urs D A Müller-Richter
INTRODUCTION: Spindle cell rhabdomyosarcoma of the head and neck is a very rare tumor in adults. We report on one case with long-term survival. CASE PRESENTATION: A 41-year-old nonsmoking Caucasian man presented in June 2007 with a painless swelling under his tongue. A diagnosis of a soft tissue sarcoma, and a myofibrosarcoma in particular, was made via biopsy. After multimodal treatment, including local and systemic therapy, our patient remained disease-free until September 2010...
2014: Journal of Medical Case Reports
Travis R Newberry, Christopher R Kaufmann, Frank R Miller
OBJECTIVE: The current study presents our experience with accessory parotid gland masses and reviews the literature on accessory parotid tumor incidence and surgical management. Based on our results, we advocate a standard parotidectomy approach with routine facial nerve dissection at the time of excision. STUDY DESIGN: We performed a retrospective chart review and comprehensive literature review on incidence of accessory parotid gland neoplasms. METHODS: A retrospective chart review of all patients with mid-cheek masses treated by the senior author was conducted from January 2003 to January 2009...
January 2014: American Journal of Otolaryngology
Tsuyoshi Saito, Hiroyuki Mitomi, Aiko Kurisaki, Tomoaki Torigoe, Tatsuya Takagi, Yoshiyuki Suehara, Taketo Okubo, Kazuo Kaneko, Takashi Yao
INTRODUCTION: Low-grade myofibroblastic sarcoma (myofibrosarcoma) is described to be a distinct atypical myofibroblastic tumor often with fibromatosis-like features and predilection for head and neck. Low-grade myofibroblastic sarcoma of bone is extremely rare. PRESENTATION OF CASE: A 50-year-old woman was admitted to our hospital because she had experienced right knee pain for 2 years. Plain radiography showed a honeycombed lesion on the right distal femur, and computed tomography showed a bone tumor with cortex destruction invading the soft tissue...
2013: International Journal of Surgery Case Reports
Fredrik Petersson, Kwok Seng Loh
We present a carcinosarcoma ex non-recurrent pleomorphic adenoma composed of a large cell neuroendocrine carcinomatous component and a spindle cell sarcoma with myofibroblastic differentiation. The tumor contained a hyalinized transition zone where the classical PA appeared to acquire two different histopathological patterns of malignant transformation of the epithelial component. The carcinomatous component was strongly and diffusely positive for low-molecular weight cytokeratins (AE1-3), synaptophysin, thyroid transcription factor-1 and focally positive for chromogranin A...
June 2013: Head and Neck Pathology
Patrick Shenjere, Brian Eyden, S Sankar Banerjee, Bipasha Chakrabarty, Jonathan H Shanks, Kanwal A Sikand, Lia P Menasce
Some view ultrastructure as key to myofibrosarcoma diagnosis, whereas others argue that electron microscopy is too little used in contemporary practice to be considered an important diagnostic tool. These views are discussed in the context of 10 ultrastructurally confirmed cases of myofibrosarcoma, some occurring at rare sites such as skin and penis. Patient age ranged from 21 to 83 years, with a 6:4 male to female ratio. Size ranged from 2 to 7.5 cm and all had infiltrative margins. Histologically, all consisted of variably cellular fascicles of spindle cells with mild to moderately pleomorphic nuclei, small punctate nucleoli, and eosinophilic cytoplasm...
February 2013: International Journal of Surgical Pathology
L Montebugnoli, M Venturi, D B Gissi, F Flamminio, M P Foschini
Low-grade myofibroblastic sarcoma is a malignant tumour from myofibroblasts, which has only recently become clearly defined. It represents a rare entity developing in the soft tissues of the head and neck. About 20 cases have been reported in the oral cavity, especially in the tongue and bone, while gingiva as the primary site has been described only once to date. Diagnostic methods include histology and immunohistochemistry. The present report concerns a case of a 37-year-old man who presented with a persistent gingival ulcerated swelling that was interpreted for a long time as a gingival epulis...
2010: BMJ Case Reports
A Mete, L Woods, D Famini, M Anderson
The pathological and diagnostic features of a widely disseminated pleomorphic high-grade myofibroblastic sarcoma are described in a 23-year-old male brown bear (Ursus arctos horribilis). Firm, solid, white to tan neoplastic nodules, often with cavitated or soft grey-red necrotic centres, were observed throughout most internal organs, subcutaneous tissues and skeletal muscles on gross examination. Microscopically, the tumour consisted of pleomorphic spindle cells forming interlacing fascicles with a focal storiform pattern with large numbers of bizarre polygonal multinucleate cells, frequently within a collagenous stroma...
August 2012: Journal of Comparative Pathology
S Tyler Hollmig, Reena Sachdev, Clay J Cockerell, William Posten, Melissa Chiang, Jinah Kim
Cutaneous spindle cell tumors share the common feature of appearing as spindle-shaped cells on light microscopy. Their pathogenesis, presentation, and prognosis are highly variable, and numerous techniques for workup and treatment have been reported. We performed an analysis of the available scientific literature in order to codify the clinical, immunohistochemical, and biologic features of these tumors and to provide insight into the most effective practices for their management, with a focus on Mohs micrographic surgery (MMS)...
June 2012: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Liu Hong-sheng, Qin Ying-zhi, Li Shan-qing, Li Li, Cui Yu-shang, Zhang Zhi-yong
OBJECTIVE: To evaluate the use of titanium mesh reconstruction after sternal tumor resection. METHODS: From January 2007 to January 2011, 14 patients with sternal tumors were admitted into Peking Union Medical Hospital. The clinical characteristics, surgical resection, and technique of reconstruction were reviewed. RESULTS: Of the 14 patients, 3 had a metastatic sternal tumor, the primary sites of which were as follows: hepatic carcinoma in one case (metastasis 19 years after operation), breast carcinoma in another case (metastasis 5 years after operation), and renal carcinoma in the other case (found simultaneously)...
December 2011: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
Konstantinos Kourelis, Yelizaveta Shnayder, Vincent Key, Douglas Girod, Terrance Tsue
No abstract text is available yet for this article.
June 2011: Brazilian Journal of Otorhinolaryngology
Matthew Stark, Andrew Hoffmann, Zhenggang Xiong
A case of myofibrosarcoma of breast is reported. A female patient aged 81 years presented with a mammary mass lesion. Histologically, the tumor consisted of neoplastic spindle cells arranged in fascicles and with variably cellularity and hyalinization. Immunohistochemical studies showed expression of vimentin, smooth-muscle actin, and Bcl-2, but not desmin, S-100, C-kit, or CD34. Proliferative index identified by Ki67 was approximately 30%. Electron microscopy revealed variable amount of rough endoplasmic reticulum, myofilaments, fibronexus junctions, and fibronectin fibrils...
May 2011: Breast Journal
Tiziana A L Brevini, Georgia Pennarossa, Stefania Antonini, Alessio Paffoni, Gianluca Tettamanti, Tiziana Montemurro, Enrico Radaelli, Lorenza Lazzari, Paolo Rebulla, Eugenio Scanziani, Magda de Eguileor, Nissim Benvenisty, Guido Ragni, Fulvio Gandolfi
Human parthenogenetic embryos have recently been proposed as an alternative, less controversial source of embryonic stem cell (ESC) lines; however many aspects related to the biology of parthenogenetic embryos and parthenogenetic derived cell lines still need to be elucidated. We present here results on human cell lines (HP1 and HP3) derived from blastocysts obtained by oocyte parthenogenetic activation. Cell lines showed typical ESC morphology, expressed Oct-4, Nanog, Sox-2, Rex-1, alkaline phosphatase, SSEA-4, TRA 1-81 and had high telomerase activity...
December 2009: Stem Cell Reviews
S Schröder, B Stengel, A Radtke, D Kleemann
BACKGROUND: Myofibroblastic sarcomas or myofibrosarcoma, are extremely rare malignant neoplasms of myofibroblasts. They are characterized by the pattern of cells and special immunohistochemical markers such as vimentin, desmin and alpha-smooth-muscle actin. PATIENT AND METHOD: The case of a patient with a history of frequently relapsing papillomas of the larynx is reported. Chronic laryngitis with focal low-grade dysplasia of the squamous epithelium was diagnosed approximately 1 year after the first treatment of the papillomas...
December 2009: HNO
A Lioulias, P Misthos, K Neofotistos, S Legaki
Primary myofibrosarcoma (MFS), or myofibroblastic sarcoma of the lung, is a rare tumor. A 47-year-old man with a history of melanoma presented with a central tumor of the left lung. The initial diagnosis was inflammatory myofibroblastic tumor but after extensive pathologic analysis MFS of the lung was confirmed. He underwent left pneumonectomy and died on the 6th postoperative month. This is the second case of primary pulmonary MFS to be reported.
January 2009: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
A Netten, W Kurth
No abstract text is available yet for this article.
December 2008: Revue Médicale de Liège
Hua Guo, Yan Xiong, Lin Nong, Shuang Zhang, Ting Li
OBJECTIVE: Since malignant fibrous histiocytoma (MFH) may be taken as an undifferentiated pleomorphic sarcoma (UPS), this study was conducted to reassess 33 previously diagnosed MFH cases in the past 10 years based on the latest WHO concept. And then to search for the clinicopathological features, probably tumorigenesis, and the line of differentiation of the remaining MFH/UPS cases. METHODS: Thirty-three cases in tissue microarray were studied by immunohistochemistry with panels of neurogenic, myogenic, and lipogenic antibodies...
August 18, 2008: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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