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https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#1
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27881672/mineralocorticoid-receptor-deficiency-in-macrophages-inhibits-atherosclerosis-by-affecting-foam-cell-formation-and-efferocytosis
#2
Zhu-Xia Shen, Xiao-Qing Chen, Xue-Nan Sun, Jian-Yong Sun, Wu-Chang Zhang, Xiao-Jun Zheng, Yu-Yao Zhang, Huan-Jing Shi, Jia-Wei Zhang, Chao Li, Jun Wang, Xu Liu, Sheng-Zhong Duan
Mineralocorticoid receptor (MR) has been considered as a potential target for treating atherosclerosis. However, the cellular and molecular mechanisms are not completely understood. We aim to explore the functions and mechanisms of macrophage MR in atherosclerosis. Atherosclerosis-susceptible LDLRKO chimeric mice with bone marrow cells from floxed control (FC) mice or from myeloid MR knockout (MRKO) mice were generated and fed with high cholesterol diet. Oil red O staining showed that MRKO decreased atherosclerotic lesion area in LDLRKO mice...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27881291/assessment-of-carotid-plaque-inflammation-in-diabetic-and-nondiabetic-patients-an-exploratory-ultrasmall-superparamagnetic-iron-oxide-enhanced-magnetic-resonance-imaging-study
#3
Ammara Usman, Andrew J Patterson, Umar Sadat, Tjun Y Tang, Martin J Graves, Jonathan H Gillard
BACKGROUND: Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging enables the identification of inflammation within the atheroma, predominantly by USPIO uptake by macrophages present in atherosclerotic tissue. Diabetic patients, however, may have dysfunctional macrophage activity, which may affect utilization of USPIO in identifying plaque inflammation in this patient cohort. METHODS: Fifteen diabetic and fifteen nondiabetic patients underwent USPIO-enhanced carotid MR imaging using 1...
November 21, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27878405/a-comparison-study-between-3d-t2-weighted-space-and-conventional-2d-t2-weighted-turbo-spin-echo-in-assessment-of-carotid-plaque
#4
Peng Lv, Yuanyuan Dai, Jiang Lin, Weisheng Zhang, Hao Liu, Hui Liu, Xiao Tang
The aim of this study was to compare 3D T2-weighted sampling perfection with application optimized contrast using different flip angle evolutions (T2w SPACE) with conventional 2D T2w turbo-spin echo (TSE) in plaque imaging of carotid artery. 45 patients underwent 3.0-T MRI for carotid arteries imaging. MR sequences included T2w SPACE, T2w TSE, Time of flight (TOF) and T1-weighted (T1w) TSE. The signal intensity of intra-plaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), and loose matrix (LM) were measured and their contrast ratios (CRs) against adjacent muscle were calculated...
November 22, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27875002/superparamagnetic-nanoparticle-enhanced-mri-of-alzheimer-s-disease-plaques-and-activated-microglia-in-3x-transgenic-mouse-brains-contrast-optimization
#5
Marissa A Tafoya, Saaussan Madi, Laurel O Sillerud
PURPOSE: To optimize magnetic resonance imaging (MRI) of antibody-conjugated superparamagnetic nanoparticles for detecting amyloid-β plaques and activated microglia in a 3X transgenic mouse model of Alzheimer's disease. MATERIALS AND METHODS: Ten 3X Tg mice were fed either chow or chow containing 100 ppm resveratrol. Four brains, selected from animals injected with either anti-amyloid targeted superparamagnetic iron oxide nanoparticles, or anti-Iba-1-conjugated FePt-nanoparticles, were excised, fixed with formalin, and placed in Fomblin for ex vivo MRI (11...
November 22, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27856437/quantifying-intracranial-plaque-permeability-with-dynamic-contrast-enhanced-mri-a-pilot-study
#6
P Vakil, A H Elmokadem, F H Syed, C G Cantrell, F H Dehkordi, T J Carroll, S A Ansari
BACKGROUND AND PURPOSE: Intracranial atherosclerotic disease plaque hyperintensity and/or gadolinium contrast enhancement have been studied as imaging biomarkers of acutely symptomatic ischemic presentations using single static MR imaging measurements. However, the value in modeling the dynamics of intracranial plaque permeability has yet to be evaluated. The purpose of this study was to use dynamic contrast-enhanced MR imaging to quantify the contrast permeability of intracranial atherosclerotic disease plaques in symptomatic patients and to compare these parameters against existing markers of plaque volatility using black-blood MR imaging pulse sequences...
November 17, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27851995/key-clinical-benefits-of-neuroimaging-at-7t
#7
Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7T, is related to improved clinical results with regard to morphological as well as functional and metabolic capabilities. Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7T is to gain higher spatial resolution in the brain compared to 3T. Of specific clinical interest for neuro applications is the cerebral cortex at 7T, for the detection of changes in cortical structure, like the visualization of cortical microinfarcts and cortical plaques in Multiple Sclerosis...
November 13, 2016: NeuroImage
https://www.readbyqxmd.com/read/27801780/preoperative-3d-fse-t1-weighted-mr-plaque-imaging-for-severely-stenotic-cervical-ica-accuracy-of-predicting-emboli-during-carotid-endarterectomy
#8
Yasushi Ogasawara, Yuiko Sato, Shinsuke Narumi, Makoto Sasaki, Shunrou Fujiwara, Masakazu Kobayashi, Kenji Yoshida, Yasuo Terayama, Kuniaki Ogasawara
The aim of the present study was to determine whether preoperative three-dimensional (3D) fast spin-echo (FSE) T1-weighted magnetic resonance (MR) plaque imaging for severely stenotic cervical carotid arteries could accurately predict the development of artery-to-artery emboli during exposure of the carotid arteries in carotid endarterectomy (CEA). Seventy-five patients underwent preoperative MR plaque imaging and CEA under transcranial Doppler ultrasonography of the ipsilateral middle cerebral artery. On reformatted axial MR image slices showing the maximum plaque occupation rate (POR) and maximum plaque intensity for each patient, the contrast ratio (CR) was calculated by dividing the internal carotid artery plaque signal intensity by the sternocleidomastoid muscle signal intensity...
October 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27789453/utility-of-a-multiparametric-quantitative-mri-model-that-assesses-myelin-and-edema-for-evaluating-plaques-periplaque-white-matter-and-normal-appearing-white-matter-in-patients-with-multiple-sclerosis-a-feasibility-study
#9
A Hagiwara, M Hori, K Yokoyama, M Y Takemura, C Andica, K K Kumamaru, M Nakazawa, N Takano, H Kawasaki, S Sato, N Hamasaki, A Kunimatsu, S Aoki
BACKGROUND AND PURPOSE: T1 and T2 values and proton density can now be quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can also be estimated from these values. The purpose of this study was to evaluate a multiparametric quantitative MR imaging model that assesses myelin and edema for characterizing plaques, periplaque white matter, and normal-appearing white matter in patients with MS. MATERIALS AND METHODS: We examined 3T quantitative MR imaging data from 21 patients with MS...
October 27, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27776656/characterization-of-atherosclerotic-disease-in-thoracic-aorta-a-3d-multicontrast-vessel-wall-imaging-study
#10
Changwu Zhou, Huiyu Qiao, Le He, Chun Yuan, Huijun Chen, Qiang Zhang, Rui Li, Wei Wang, Fang Du, Cheng Li, Xihai Zhao
PURPOSE: To investigate the characteristics of plaque in the thoracic aorta using three dimensional multicontrast magnetic resonance imaging. MATERIALS AND METHODS: Elderly subjects (≥60years) were recruited in this study. Thoracic aorta was imaged on a 3.0T MR scanner by acquiring multicontrast sequences. The plaque burden was evaluated by measuring lumen area, wall area, wall thickness, and normalized wall index. The presence or absence of plaque and intraplaque hemorrhage (IPH)/mural thrombus (MT) were identified...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27765555/magnetic-resonance-imaging-based-assessment-of-carotid-atheroma-a-comparative-study-of-patients-with-and-without-coronary-artery-disease
#11
Ammara Usman, Umar Sadat, Zhongzhao Teng, Martin J Graves, Jonathan R Boyle, Kevin Varty, Paul D Hayes, Jonathan H Gillard
BACKGROUND: Functional magnetic resonance (MR) imaging of atheroma using contrast media enables assessment of the systemic severity of atherosclerosis in different arterial beds. Whether black-blood imaging has similar ability remains widely unexplored. In this study, we evaluate whether black-blood imaging can differentiate carotid plaques of patients with and without coronary artery disease (CAD) in terms of morphological and biomechanical features of plaque vulnerability, thereby allowing assessment of the systemic severity nature of atherosclerosis in different arterial beds...
October 17, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27743726/automated-registration-of-freehand-b-mode-ultrasound-and-magnetic-resonance-imaging-of-the-carotid-arteries-based-on-geometric-features
#12
Diego D B Carvalho, Andres Mauricio Arias Lorza, Wiro J Niessen, Marleen de Bruijne, Stefan Klein
An automated method for registering B-mode ultrasound (US) and magnetic resonance imaging (MRI) of the carotid arteries is proposed. The registration uses geometric features, namely, lumen centerlines and lumen segmentations, which are extracted fully automatically from the images after manual annotation of three seed points in US and MRI. The registration procedure starts with alignment of the lumen centerlines using a point-based registration algorithm. The resulting rigid transformation is used to initialize a rigid and subsequent non-rigid registration procedure that jointly aligns centerlines and segmentations by minimizing a weighted sum of the Euclidean distance between centerlines and the dissimilarity between segmentations...
January 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27665272/old-hearts-for-modern-investigations-ct-and-mr-for-archaeological-human-hearts-remains
#13
F Z Mokrane, R Colleter, S Duchesne, P Gerard, F Savall, E Crubezy, C Guilbeau-Frugier, R Moreno, A Sewonu, H Rousseau, N Telmon, F Dedouit
INTRODUCTION: Among 800 burials dated between the 15th and 18th centuries and found in the center of Rennes (Brittany, France), a collection of five heart-shaped lead urns was discovered. This material was studied using classical methods (external study, autopsy and histology), and also modern imaging like computed tomography (CT), magnetic resonance (MR) before and after coronary opacification. The aim of this manuscript is to describe different steps of ancient soft tissues study, especially using imaging techniques...
September 14, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27659455/pet-mr-yet-another-tesla
#14
Markus Schwaiger, Karl Kunze, Christoph Rischpler, Stephan G Nekolla
After the successful introduction of PET/CT as a multimodality imaging technique, PET/MR has subsequently emerged as an attractive instrumentation for applications in neurology, oncology, and cardiology. Simultaneous data acquisition combining structural, functional, and molecular imaging provides a unique platform to link various aspects of cardiac performance for the non-invasive characterization of cardiovascular disease phenotypes. Specifically, tissue characterization by MR techniques with and without contrast agents allows for functional parameters such as LGE, myocardial perfusion, and T1 maps as well as an estimate of extracellular volume...
September 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27659454/cardiovascular-pet-mr-imaging-quo-vadis
#15
Thomas Hellmut Schindler
With the recent advent of PET/MRI scanners, the combination of molecular imaging with a variety of known and novel PET radiotracers, the high spatial resolution of MRI, and its potential for multi-parametric imaging are anticipated to increase the diagnostic accuracy in cardiovascular disease detection, while providing novel mechanistic insights into the initiation and progression of the disease state. For the time being, cardiac PET/MRI emerges as potential clinical tool in the identification and characterization of infiltrative cardiac diseases, such as sarcoidosis, acute or chronic myocarditis, and cardiac tumors, respectively...
September 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27659155/puncturing-plaques-relating-mri-characteristics-of-peripheral-artery-lesions-to-guidewire-puncture-forces
#16
Trisha Roy, Garry Liu, Noor Shaikh, Andrew D Dueck, Graham A Wright
PURPOSE: To test and validate magnetic resonance imaging (MRI) sequences for peripheral artery lesion characterization and relate the MRI characteristics to the amount of force required for a guidewire to puncture peripheral chronic total occlusions (CTOs) as a surrogate for immediate failure of endovascular therapy. METHODS: Diseased superficial femoral, popliteal, and tibial artery segments containing 55 atherosclerotic lesions were excised from the amputated limbs of 7 patients with critical limb ischemia...
September 22, 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27648374/feasibility-of-carotid-artery-pet-mri-in-psoriasis-patients
#17
Prabhakar Rajiah, Mojgan Hojjati, Ziang Lu, Vijaya Kosaraju, Sasan Partovi, James K O'Donnell, Christopher Longenecker, Grace A McComsey, Jackelyn B Golden, Fuad Muakkassa, Scott Santilli, Thomas S McCormick, Kevin D Cooper, Neil J Korman
We report our initial experience of performing integrated PET/MR imaging of the carotid arteries in psoriatic patients. Eleven patients with psoriasis and ten controls underwent carotid PET/MRI. Following injection of the FDG tracer, 3d T1w gradient echo sequence (atMR) was obtained for attenuation correction of PET data. High resolution images of carotid artery were then obtained, including pre-and post-contrast T1-w, T2-w and proton-density images as well as TOF images followed by PET imaging of the torso...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27632977/detection-of-a%C3%AE-plaque-deposition-in-mr-images-based-on-pixel-feature-selection-and-class-information-in-image-level
#18
Yongming Li, Xueru Zhu, Pin Wang, Jie Wang, Shujun Liu, Fan Li, Mingguo Qiu
BACKGROUND: Amyloid β-protein (Aβ) plaque deposition is an important prevention and treatment target for Alzheimer's disease (AD). As a noninvasive, nonradioactive and highly cost-effective clinical imaging method, magnetic resonance imaging (MRI) is the perfect imaging technology for the clinical diagnosis of AD, but it cannot display the plaque deposition directly. This paper resolves this problem based on pixel feature selection algorithms at the image level. METHODS AND RESULTS: Firstly, the brain region was segmented from mouse model brain MR images...
2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27593251/pet-mr-imaging-in-vascular-disease-atherosclerosis-and-inflammation
#19
REVIEW
Rasmus Sejersten Ripa, Sune Folke Pedersen, Andreas Kjær
For imaging of atherosclerotic disease, lumenography using computed tomography, ultrasonography, or invasive angiography is still the backbone of evaluation. However, these methods are less effective to predict the likelihood of future thromboembolic events caused by vulnerability of plaques. PET and MR imaging have been used separately with success for plaque characterization. Where MR imaging has the ability to reveal plaque composition, PET has the ability to visualize plaque activity. Together this leads to a comprehensive evaluation of plaque vulnerability...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27531859/is-size-an-essential-criterion-to-define-tumefactive-plaque-mr-features-and-clinical-correlation-in-multiple-sclerosis
#20
Lucia Patriarca, Silvia Torlone, Fabiana Ferrari, Caterina Di Carmine, Rocco Totaro, Ernesto di Cesare, Alessandra Splendiani
Tumefactive multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. It has recently been described as a rare subtype of multiple sclerosis (MS) characterised by the appearance of solitary or multiple space-occupying lesions associated with imaging characteristics mimicking neoplasm. Atypical features include plaque size >2 cm with mass effect, oedema, and/or ring enhancement on magnetic resonance (MR) images.This study is a retrospective review designed to evaluate the prevalence of tumefactive plaques in a selected population of 440 MS patients referred to our MS centre in Southern Italy between 2005 and 2014...
October 2016: Neuroradiology Journal
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