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https://www.readbyqxmd.com/read/29748315/genetic-regulation-of-pcsk9-proprotein-convertase-subtilisin-kexin-type-9-plasma-levels-and-its-impact-on-atherosclerotic-vascular-disease-phenotypes
#1
Janne Pott, Valentin Schlegel, Andrej Teren, Katrin Horn, Holger Kirsten, Christina Bluecher, Juergen Kratzsch, Markus Loeffler, Joachim Thiery, Ralph Burkhardt, Markus Scholz
BACKGROUND: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is a novel strategy to treat hypercholesterolemia and reduce cardiovascular events. However, the potential role of circulating plasma PCSK9 concentrations as a diagnostic and predictive biomarker remains uncertain as of now. Here, we aimed to identify genetic variants associated with plasma PCSK9 and investigate possible causal effects on atherosclerotic vascular disease phenotypes. METHODS: We performed the first genome-wide association study of plasma PCSK9 levels in a cohort of suspected and confirmed coronary artery disease (LIFE-Heart; n=3290)...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29745510/-detection-algorithm-of-amyloid-%C3%AE-protein-deposition-in-magnetic-resonance-image-based-on-pixel-feature-learning-method
#2
Fang Yan, Yongming Li, Xueru Zhu, Jie Wang, Pin Wang, Fan Li, Mingguo Qiu, Jian Qin
Amyloid β-protein (Aβ) deposition is an important prevention and treatment target for Alzheimer's disease (AD), and early detection of Aβ deposition in the brain is the key to early diagnosis of AD. Magnetic resonance imaging (MRI) is the perfect imaging technology for the clinical diagnosis of AD, but it cannot display the plaque deposition directly. In this paper, based on two feature selection modes-filter and wrapper, chain-like agent genetic algorithm (CAGA), principal component analysis (PCA), support vector machine (SVM) and random forest (RF), we designed six kinds of feature learning classification algorithms to detect the information (distribution) of Aβ deposition through magnetic resonance image pixels selection...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29714679/mr-imaging-features-of-retinoblastoma-association-with-gene-expression-profiles
#3
Robin W Jansen, Marcus C de Jong, Irsan E Kooi, Selma Sirin, Sophia Göricke, Hervé J Brisse, Philippe Maeder, Paolo Galluzzi, Paul van der Valk, Jacqueline Cloos, Iris Eekhout, Jonas A Castelijns, Annette C Moll, Josephine C Dorsman, Pim de Graaf
Purpose To identify associations between magnetic resonance (MR) imaging features and gene expression in retinoblastoma. Materials and Methods A retinoblastoma MR imaging atlas was validated by using anonymized MR images from referral centers in Essen, Germany, and Paris, France. Images were from 39 patients with retinoblastoma (16 male and 18 female patients [the sex in five patients was unknown]; age range, 5-90 months; inclusion criterion: pretreatment MR imaging). This atlas was used to compare MR imaging features with genome-wide messenger RNA (mRNA) expression data from 60 consecutive patients obtained from 1995 to 2012 (35 male patients [58%]; age range, 2-69 months; inclusion criteria: pretreatment MR imaging, genome-wide mRNA expression data available)...
May 1, 2018: Radiology
https://www.readbyqxmd.com/read/29685528/diagnostic-value-of-3dflair-in-clinical-practice-for-the-detection-of-infratentorial-lesions-in-multiple-sclerosis-in-regard-to-dual-echo-t2-sequences
#4
Salem Hannoun, Damien Heidelberg, Roula Hourani, Thi Thuy Trang Nguyen, Jean-Christophe Brisset, Sylvie Grand, Stéphane Kremer, Fabrice Bonneville, Charles R G Guttmann, Vincent Dousset, François Cotton
BACKGROUND AND PURPOSE: The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS). MATERIAL AND METHODS: 164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29683503/diagnostic-accuracy-of-clinical-parameters-to-monitor-peri-implant-conditions-a-matched-case-control-study
#5
Alberto Monje, Jordi Caballé-Serrano, Jose Nart, David Peñarrocha, Hom-Lay Wang, Mia Rakic
BACKGROUND: The aim of this case-control study was to estimate the diagnostic accuracy of the standard clinical parameters in diagnosing healthy peri-implant tissues, peri-implant mucositis, and peri-implantitis. METHODS: A case-control study was designed to compare the clinical parameters used in the diagnosis of peri-implant diseases such as: probingdepth (PD), bleeding on probing (BOP), mucosal redness (MR), suppuration (SUP), and plaque index (PI). Furthermore, the influence of patient- (sex, age) and implant-related variables (implant neck configuration, time in function after loading) were evaluated to investigate the association with the clinical findings...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29681782/early-detection-of-a-%C3%AE-deposition-in-the-5xfad-mouse-by-amyloid-pet
#6
Se Jong Oh, Hae-June Lee, Kyung Jun Kang, Sang Jin Han, Yong Jin Lee, Kyo Chul Lee, Sang Moo Lim, Dae Yoon Chi, Kyeong Min Kim, Ji-Ae Park, Jae Yong Choi
Purpose. 18 F-FC119S is a positron emission tomography (PET) tracer for imaging β -amyloid (A β ) plaques in Alzheimer's disease (AD). The aim of this study is to evaluate the efficacy of 18 F-FC119S in quantitating A β deposition in a mouse model of early amyloid deposition (5xFAD) by PET. Method . Dynamic 18 F-FC119S PET images were obtained in 5xFAD ( n = 5) and wild-type (WT) mice ( n = 7). The brain PET images were spatially normalized to the M. Mirrione T2-weighted mouse brain MR template, and the volumes of interest were then automatically drawn on the cortex, hippocampus, thalamus, and cerebellum...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29675360/deep-infiltrating-endometriosis-mr-imaging-with-surgical-correlation
#7
REVIEW
Xue Tang, Rennan Ling, Jingshan Gong, Dongdong Mei, Yan Luo, Minge Li, Jianmin Xu, Liguo Ma
In this pictorial review, MR imaging findings of deep infiltrating endometriosis (DIE) are illustrated together with surgical correlation. DIE can appear as irregular nodules or plaques with similar signal intensity to muscle on both T1-weighted and T2-weighted images. Hemorrhage foci and strands or stellate margins are also often noted. Restriction of diffusion can be seen on diffusion-weighted image. Fibrosis and adhesions often result in morphologic changes, such as alimentary tract tortuosity, irregular or nodular thickening of uterosacral ligaments, and partial or complete obliteration of the pouch of Douglas...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29669957/association-of-age-and-size-of-carotid-artery-intraplaque-hemorrhage-and-minor-fibrous-cap-disruption-a-high-resolution-magnetic-resonance-imaging-study
#8
Yuanyuan Cui, Huiyu Qiao, Lu Ma, Mingming Lu, Jiafei Yang, Guoen Yao, Jianming Cai, Xihai Zhao
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS: Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated...
April 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29668907/the-mineralocorticoid-receptor-as-a-modulator-of-innate-immunity-and-atherosclerosis
#9
Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
The mineralocorticoid receptor (MR) is a member of the nuclear receptor steroid-binding family. The classical MR ligand aldosterone controls electrolyte and fluid homeostasis after binding in renal epithelial cells. However, more recent evidence suggests that activation of extrarenal MRs by aldosterone negatively impacts cardiovascular health independent of its effects on blood pressure: high levels of aldosterone associate with an increased cardiovascular event rate, where MR antagonists exert beneficial effects on cardiovascular mortality...
April 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29602861/relationship-between-stroke-recurrence-infarct-pattern-and-vascular-distribution-in-patients-with-symptomatic-intracranial-stenosis
#10
Karthikram Raghuram, Aditya Durgam, Jennifer Kohlnhofer, Ayush Singh
OBJECTIVE: In view of recent literature suggesting that stroke recurrence and risks related to intervention may be related to plaque physiology/instability, our study sought to discern the pattern of stroke and rates of stoke recurrence as they relate to the anatomy and presentation of the underlying stenosis. METHODS: Retrospective chart as well as CT and MR angiographic imaging review of patients in the institutional stroke database was performed, including identification of patient risk factors, medical therapeutic optimization, compliance, serum cholesterol (low density lipoprotein) levels, blood pressure, physical therapy referrals, follow-up clinical status (using the modified Rankin Scales), and rate of recurrent stroke...
March 30, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29602139/new-methods-to-image-unstable-atherosclerotic-plaques
#11
REVIEW
Jack P M Andrews, Zahi A Fayad, Marc R Dweck
Atherosclerotic plaque rupture is the primary mechanism responsible for myocardial infarction and stroke, the top two killers worldwide. Despite being potentially fatal, the ubiquitous prevalence of atherosclerosis amongst the middle aged and elderly renders individual events relatively rare. This makes the accurate prediction of MI and stroke challenging. Advances in imaging techniques now allow detailed assessments of plaque morphology and disease activity. Both CT and MR can identify certain unstable plaque characteristics thought to be associated with an increased risk of rupture and events...
March 14, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29572319/ossabaw-pigs-with-a-pcsk9-gain-of-function-mutation-develop-accelerated-coronary-atherosclerotic-lesions-a-novel-model-for-preclinical-studies
#12
Fang Yuan, Liang Guo, Kyoung-Ha Park, John R Woollard, Kwon Taek-Geun, Kai Jiang, Tamene Melkamu, Bin Zang, Samantha L Smith, Scott C Fahrenkrug, Frank D Kolodgie, Amir Lerman, Renu Virmani, Lilach O Lerman, Daniel F Carlson
BACKGROUND: Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic Ossabaw swine expressing chimp PCSK9 (proprotein convertase subtilisin-like/kexin type 9) containing the D374Y gain of function would develop familial hypercholesterolemia and coronary artery plaques more rapidly than Landrace swine with the same transgene. METHODS AND RESULTS: Ossabaw and Landrace PCSK9 gain-of-function founders were generated by Sleeping Beauty transposition and cloning...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29566551/in-vivo-mri-detection-of-atherosclerosis-in-apoe-deficient-mice-by-using-tenascin-c-targeted-uspio
#13
Yan Li, Jun Liu, Jun-Wen Huang, Jia-Cheng Song, Zhan-Long Ma, Hai-Bin Shi
Background Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases. Non-invasive molecular imaging to detect and characterize the plaques is essential for reducing life-threatening cardiovascular events. Purpose To investigate the possibility of the anti-tenascin-C-USPIO specific probe as a molecular marker of atherosclerotic plaques detected by 7.0-T magnetic resonance imaging (MRI). Material and Methods Twenty ApoE-/- mice fed with a high fat diet were used for detecting the aorta arch atherosclerotic plaques by 7...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29540643/contrast-enhanced-high-resolution-mri-for-evaluating-time-course-changes-in-middle-cerebral-artery-plaques
#14
Arata Abe, Tetsuro Sekine, Yuki Sakamoto, Mina Harada-Abe, Ryo Takagi, Satoshi Suda, Kentaro Suzuki, Junya Aoki, Masami Yoneyama, Kazumi Kimura
BACKGROUND AND PURPOSE: It is clinically important to evaluate time course changes in symptomatic middle cerebral artery (MCA) stenotic plaques because of likely recurrence. The objective of this study is to determine whether contrast-enhanced high-resolution magnetic resonance imaging (MRI) is a feasible method for this purpose. METHODS: Contrast-enhanced, high-resolution, 3D turbo spin-echo images with low refocusing flip angle control (3D LOWRAT) applied to 7 patients with symptomatic MCA stenosis were evaluated at the initial (1 month after stroke onset) and follow-up (7 months after stroke onset) stages, and statistical variables, including plaque-to-thalamus signal intensity ratio, degree of stenosis, and stroke recurrence obtained at the 2 stages, were compared...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29520165/silencing-mr-1-attenuates-atherosclerosis-in-apoe-mice-induced-by-angiotensin-ii-through-fak-akt-mtor-nf-kappab-signaling-pathway
#15
Yixi Chen, Jianping Cao, Qihui Zhao, Haiyong Luo, Yiguang Wang, Wenjian Dai
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB (NF-κB) signaling pathway, and atherosclerotic lesion macrophage content...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29494349/phenotypic-multiorgan-involvement-of-subclinical-disease-as-quantified-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-glucose-tolerance
#16
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
June 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29491833/plasma-amyloid-is-associated-with-white-matter-and-subcortical-alterations-and-is-modulated-by-age-and-seasonal-rhythms-in-mouse-lemur-primates
#17
Charlotte Gary, Anne-Sophie Hérard, Zoé Hanss, Marc Dhenain
Accumulation of amyloid-β (Aβ) peptides in the brain is a critical early event in the pathogenesis of Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. There is increasing interest in measuring levels of plasma Aβ since this could help in diagnosis of brain pathology. However, the value of plasma Aβ in such a diagnosis is still controversial and factors modulating its levels are still poorly understood. The mouse lemur ( Microcebus murinus ) is a primate model of cerebral aging which can also present with amyloid plaques and whose Aβ is highly homologous to humans'...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29487319/magnetic-resonance-imaging-of-atherosclerotic-plaque-at-clinically-relevant-field-strengths-1t-by-targeting-the-integrin-%C3%AE-4%C3%AE-1
#18
Darren G Woodside, Eric A Tanifum, Ketan B Ghaghada, Ronald J Biediger, Amy R Caivano, Zbigniew A Starosolski, Sayadeth Khounlo, Saakshi Bhayana, Shahrzad Abbasi, John W Craft, David S Maxwell, Chandreshkumar Patel, Igor V Stupin, Deenadayalan Bakthavatsalam, Robert V Market, James T Willerson, Richard A F Dixon, Peter Vanderslice, Ananth V Annapragada
Inflammation drives the degradation of atherosclerotic plaque, yet there are no non-invasive techniques available for imaging overall inflammation in atherosclerotic plaques, especially in the coronary arteries. To address this, we have developed a clinically relevant system to image overall inflammatory cell burden in plaque. Here, we describe a targeted contrast agent (THI0567-targeted liposomal-Gd) that is suitable for magnetic resonance (MR) imaging and binds with high affinity and selectivity to the integrin α4β1(very late antigen-4, VLA-4), a key integrin involved in recruiting inflammatory cells to atherosclerotic plaques...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29479763/diagnostic-accuracy-of-a-clinical-carotid-plaque-mr-protocol-using-a-neurovascular-coil-compared-to-a-surface-coil-protocol
#19
Waleed Brinjikji, J Kevin DeMarco, Robert Shih, Giuseppe Lanzino, Alejandro A Rabinstein, Christopher A Hilditch, Patrick J Nicholson, John Huston
BACKGROUND: Carotid plaque imaging with MRI is becoming more commonplace, but practical challenges exist in performing plaque imaging with surface coils. PURPOSE: To compare the diagnostic performance of a carotid plaque MRI protocol using a standard neurovascular coil (Neurovascular Coil Protocol) to a higher-resolution carotid plaque MRI using carotid surface coils (Surface Coil Protocol) in characterizing carotid plaque. STUDY TYPE: Prospective study comparing two MR techniques in plaque characterization...
February 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29415084/mr-guided-transcranial-focused-ultrasound-safely-enhances-interstitial-dispersion-of-large-polymeric-nanoparticles-in-the-living-brain
#20
David S Hersh, Pavlos Anastasiadis, Ali Mohammadabadi, Ben A Nguyen, Sijia Guo, Jeffrey A Winkles, Anthony J Kim, Rao Gullapalli, Asaf Keller, Victor Frenkel, Graeme F Woodworth
Generating spatially controlled, non-destructive changes in the interstitial spaces of the brain has a host of potential clinical applications, including enhancing the delivery of therapeutics, modulating biological features within the tissue microenvironment, altering fluid and pressure dynamics, and increasing the clearance of toxins, such as plaques found in Alzheimer's disease. Recently we demonstrated that ultrasound can non-destructively enlarge the interstitial spaces of the brain ex vivo. The goal of the current study was to determine whether these effects could be reproduced in the living brain using non-invasive, transcranial MRI-guided focused ultrasound (MRgFUS)...
2018: PloS One
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