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Cerebral MR PLaque

V Yu Usov, M L Belyanin, E E Bobrikova, O Yu Borodin, N L Shimanovsky, T V Minenko, I L Bukhovets, M P Plotnikov, B N Kozlov, V M Shipulin
The authors studied a possibility of simultaneously performing magnetic resonance (MR) angiography of carotid arteries and contrast-enhanced MR tomography of atherosclerotic plaques of carotid arteries. We examined a total of 16 patients presenting with disseminated atherosclerosis and 8 patients of the control group. Quadrature coils for examination of the head were used in order to sequentially perform MR tomography of the brain, MR angiography of carotid arteries and MR tomography of atherosclerotic plaques of carotid arteries with contrasting by 0...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Xin Xu, Yafen Wei, Xiandong Zhang, Lili Yang, Zhitang Cui, Junjie Yan
PURPOSE: To investigate the correlation between middle cerebral atherosclerosis and capsular warning syndrome (CWS) and assess the value of higher-resolution magnetic resonance imaging (MRI) in prognostication. MATERIALS AND METHODS: In all, 97 transient ischemic attack (TIA) patients who underwent an MRI from February 2010 to December 2013 were included in the retrospective study and divided into either a CWS or middle cerebral artery (MCA) TIA group according to their eventual clinical diagnosis...
April 15, 2016: Journal of Magnetic Resonance Imaging: JMRI
Y Sato, K Ogasawara, S Narumi, M Sasaki, A Saito, E Tsushima, T Namba, M Kobayashi, K Yoshida, Y Terayama, A Ogawa
BACKGROUND AND PURPOSE: Preoperative identification of plaque vulnerability may allow improved risk stratification for patients considered for carotid endarterectomy. The present study aimed to determine which plaque imaging technique, cardiac-gated black-blood fast spin-echo, magnetization-prepared rapid acquisition of gradient echo, source image of 3D time-of-flight MR angiography, or noncardiac-gated spin-echo, most accurately predicts development of microembolic signals during exposure of carotid arteries in carotid endarterectomy...
June 2016: AJNR. American Journal of Neuroradiology
G H Chung, J Y Jeong, H S Kwak, S B Hwang
BACKGROUND AND PURPOSE: Carotid artery stent placement in patients with intraplaque hemorrhage remains controversial because of the incidence of cerebral embolism after the procedure. The purpose of this study is to determine if intraplaque hemorrhage is a significant risk factor for cerebral embolism during carotid artery stent placement. MATERIALS AND METHODS: This prospective study assessed 94 consecutive patients with severe carotid stenosis. These patients underwent preprocedural carotid MR imaging and postprocedural DWI after carotid artery stent placement...
April 2016: AJNR. American Journal of Neuroradiology
Xiao-Dong Zou, Yiu-Cho Chung, Lei Zhang, Ying Han, Qi Yang, Jianping Jia
PURPOSE: Conventional two-dimensional vessel wall imaging has been used to depict the middle cerebral artery (MCA) wall in patients with recent small subcortical infarctions (RSSIs). However, its clinical use has been limited by restricted spatial coverage, low signal-to-noise ratio (SNR), and long scan time. We used a novel three-dimensional high-resolution MR imaging (3D HR-MRI) technique to investigate the presence, locations, and contrast-enhanced patterns of MCA plaques and their relationship with RSSI...
2015: BioMed Research International
Florian C Maier, Marianne D Keller, Daniel Bukala, Benjamin Bender, Julia G Mannheim, Ian M Brereton, Graham J Galloway, Bernd J Pichler
UNLABELLED: We present a combined PET/7 T MR imaging and 16.4 T microscopic MR imaging dual-modality imaging approach enabling quantification of the amyloid load at high sensitivity and high resolution, and of regional cerebral blood flow (rCBF) in the brain of transgenic APP23 mice. Moreover, we demonstrate a novel, voxel-based correlative data analysis method for in-depth evaluation of amyloid PET and rCBF data. METHODS: We injected 11C-Pittsburgh compound B (PIB) intravenously in transgenic and control APP23 mice and performed dynamic PET measurements...
October 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Lei Zhang, Na Zhang, Jun Wu, Lijuan Zhang, Yanyan Huang, Xin Liu, Yiu-Cho Chung
OBJECTIVE: To study the effect of imaging parameters on the contrast of T1 weighted SPACE (Sampling Perfection with Application optimized Contrast using different angle Evolutions, a 3D TSE variant) at 3 T for high resolution imaging of intracranial plaques before contrast and with post-gadolinium induced enhancement, and evaluate its relevance to patients with intracranial atherosclerosis. MATERIALS AND METHODS: Optimized parameters giving good T1 contrast between intracranial vessel wall and cerebrospinal fluid within a specific scan time and reasonable coverage were found by simulation and validated in a healthy volunteer study...
November 2015: Magnetic Resonance Imaging
Wei Wu, Yi Guan, Kan Xu, Xi-Jia Fu, Xiao-Feng Lei, Li-Jian Lei, Zhi-Qing Zhang, Yan Cheng, Yun-Qian Li
This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 umol/L). High-resolution B-mode ultrasounds were performed to assess intima media thickness (IMT), infarcts, plaques, and stenosis in the extracranial carotid artery of these patients. All patients underwent 3 T MR scanners to evaluate cerebral artery stenosis in the intracranial cerebral artery...
May 2016: Molecular Neurobiology
Victoria Ohla, Christian Scheiwe
BACKGROUND: True multiple meningiomas are defined as meningiomas occurring at several intracranial locations simultaneously without the presence of neurofibromatosis. Though the prognosis does not differ from benign solitary meningiomas, the simultaneous occurrence of different grades of malignancy has been reported in one-third of patients with multiple meningiomas. Due to its rarity, unclear etiology, and questions related to proper management, we are presenting our case of meningiomatosis and discuss possible pathophysiological mechanisms...
2015: Surgical Neurology International
T Matsushige, Y Akiyama, T Okazaki, K Shinagawa, N Ichinose, K Awai, K Kurisu
BACKGROUND AND PURPOSE: Inflammation and degeneration of the intracranial saccular aneurysm wall play a major role in aneurysm formation, development and subsequent rupture. The aim of this study was to characterize the walls of unruptured intracranial aneurysms by using a hybrid of opposite-contrast MRA at 3T. MATERIALS AND METHODS: Fourteen consecutive patients with 17 unruptured intracranial aneurysms who initially underwent clipping surgery were prospectively evaluated...
August 2015: AJNR. American Journal of Neuroradiology
Binbin Sui, Peiyi Gao, Yan Lin, Lina Jing, Haiqiang Qin
OBJECTIVES: To investigate the distribution and features of middle cerebral artery (MCA) atherosclerotic plaques in patients with acute ischaemic strokes using high-resolution magnetic resonance (MR) imaging. METHODS: Forty-six plaques from 44 MCAs (18 right and 26 left) in patients with acute symptomatic ischaemic strokes were studied. High-resolution MR imaging including tb1 weighted imaging (T1WI), tb2 weighted imaging (T2WI), PD weighted imaging (PDWI) and three-dimensional magnetization-prepared rapid acquisition gradient-echo (MPRAGE) sequences were used to visualise the plaques...
May 2015: Neurological Research
Siegfried Trattnig, Wolfgang Bogner, Stephan Gruber, Pavol Szomolanyi, Vladimir Juras, Simon Robinson, Štefan Zbýň, Stefan Haneder
Presently, three major MR vendors provide commercial 7-T units for clinical research under ethical permission, with the number of operating 7-T systems having increased to over 50. This rapid increase indicates the growing interest in ultrahigh-field MRI because of improved clinical results with regard to morphological as well as functional and metabolic capabilities. As the signal-to-noise ratio scales linearly with the field strength (B0 ) of the scanner, the most obvious application at 7 T is to obtain higher spatial resolution in the brain, musculoskeletal system and breast...
September 2016: NMR in Biomedicine
A R Naylor, H Sillesen, T V Schroeder
OBJECTIVE: The aim of this review was to identify clinical and/or imaging parameters that are associated with an increased (decreased) risk of early/late stroke in patients with symptomatic carotid disease. IN THE FIRST 14 DAYS: Natural history studies suggest that 8-15% of patients with 50-99% stenoses will suffer a stroke within 72 hours of their index symptom. Currently, there are insufficient validated data to identify highest-risk patients for emergency carotid endarterectomy (CEA), but an increased risk of stroke appears to be predicted by (i) an ABCD(2) score of 4-7; (ii) the presence of acute cerebral injury on CT/MRI; (iii) Gray Scale Median (GSM) <15, (iv) spontaneous embolisation on Transcranial Doppler (TCD); and (v) increased fluorodeoxyglucose (FDG) uptake in the carotid plaque on positron emission tomography (PET)...
May 2015: European Journal of Vascular and Endovascular Surgery
Dengling Zhao, Gaojun Teng, Xiaohui Chen, Shenghong Ju, Gang Deng, Min Wang, Qinghai Zhang, Haimei Zhang, Zhaorui Hou
OBJECTIVE: To investigate remodeling mode of moderate or severe atherosclerotic stenosis of the middle cerebral artery (MCA) using high resolution MRI. METHODS: Thirty-seven consecutive symptomatic patients with atherosclerotic MCA stenosis were imaged with a 3.0-T magnetic resonance scanner. The HR-MRI protocol included four different scans: T1-weighted black blood imaging, T2-weighted MR, proton density (PD)-weighted MR, and 3D-SPACE. The wall area (VA), lumen area (LA) and plaque area (PA) were calculated...
October 14, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Ilya M Nasrallah, David A Wolk
Neurodegenerative diseases, such as Alzheimer disease, result in cognitive decline and dementia and are a leading cause of mortality in the growing elderly population. These progressive diseases typically have an insidious onset, with overlapping clinical features early in the disease course that make diagnosis challenging. The neurodegenerative diseases are associated with characteristic, although not completely understood, changes in the brain: abnormal protein deposition, synaptic dysfunction, neuronal injury, and neuronal death...
December 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
H Matsukawa, M Fujii, A Uemura, K Suzuki, D Yamamoto, O Takahashi, Y Niimi
BACKGROUND: The relationship between magnetic resonance (MR) plaque imaging and the pathology of distal embolic debris is unknown. We aimed to evaluate the relationship between the pathology of embolic debris in the embolic filter during carotid artery stenting (CAS), MR plaque imaging, and new ischemic lesions on diffusion-weighted imaging (DWI). METHOD: We prospectively reviewed the 36 patients who underwent CAS using a filter-type embolic protection device. Pathology of debris was categorized into thrombosis, inflammatory cells, elastic fiber, and calcification...
April 2015: Acta Neurologica Scandinavica
Masaomi Koyanagi, Kazumichi Yoshida, Yoshitaka Kurosaki, Nobutake Sadamasa, Osamu Narumi, Tsukasa Sato, Masaki Chin, Akira Handa, Sen Yamagata, Susumu Miyamoto
BACKGROUND: Reduced cerebrovascular reserve (CVR) is associated with increased risk of ischemic events in carotid steno-occlusive diseases. OBJECTIVE: To determine whether pretreatment CVR can predict postoperative ischemic lesions after carotid artery stenting (CAS) by retrospective analysis. METHODS: We retrospectively reviewed the medical records of 46 patients (42 men; mean age 74.2±8.3 years) who underwent CAS and preprocedural cerebral blood flow measurement by quantitative single-photon emission CT...
June 2016: Journal of Neurointerventional Surgery
C-W Ryu, G-H Jahng, H S Shin
BACKGROUND AND PURPOSE: High-resolution MR imaging can depict intracranial arterial atherosclerotic plaques. Our aim was to evaluate the relationship between the degree of enhancement of MCA plaques on contrast-enhanced high-resolution MR imaging and ischemic stroke and stenosis severity. MATERIALS AND METHODS: This study enrolled 36 patients diagnosed with moderate-to-severe atherosclerotic MCA stenosis. A contrast-enhanced T1-weighted volume isotropic turbo spin-echo acquisition sequence was acquired for assessing plaque enhancement...
December 2014: AJNR. American Journal of Neuroradiology
Yohei Asakawa, Hidehiro Takekawa, Keisuke Suzuki, Yuko Ishii, Masami Ohrui, Koichi Hirata
OBJECTIVE: The aim of this study was to evaluate the relationship between fatty liver disease (FLD) and cerebrovascular disease. METHODS: We conducted a cross-sectional study of 76 consecutive healthy subjects who participated in a two-day hospitalized health checkup program. The maximal intima-media thickness (IMT) of the common carotid artery and bifurcation of the carotid artery as well as the plaque score (PS) were evaluated on carotid artery ultrasonography...
2014: Internal Medicine
Xiaoli Wu, Yang Guo, Xiaoping Tan
We here in describe a case of hypereosinophilic syndrome (HES) with acute cerebral infarction in a watershed distribution with lesions of the carotid artery but no damage to the endocardium or myocardium. A 62-year-old Chinese man complained of left-sided hemiparesis. Brain MR showed multiple areas of acute ischemia. The eosinophil count was 4.84 × 10(9)/L, or 41.7 % of all white blood cells. Doppler ultrasound showed multiple medium-high echo plaques in the bilateral carotid bifurcation with reduction in diameter of 10-15 %...
October 2014: Neurological Sciences
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