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Cerebral MR PLaque

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https://www.readbyqxmd.com/read/28386716/importance-of-variants-in-cerebrovascular-anatomy-for-potential-retrograde-embolization-in-cryptogenic-stroke
#1
Michael Markl, Edouard Semaan, LeRoy Stromberg, James Carr, Shyam Prabhakaran, Jeremy Collins
OBJECTIVES: To test the hypothesis that variants in cerebrovascular anatomy will affect the number of patients demonstrating a plausible retrograde embolization mechanism from plaques in the descending aorta (DAo). METHODS: Thirty-five patients (aged 63 ± 17 years) with cryptogenic stroke underwent 4D flow MRI for the assessment of aortic 3D blood flow and MR angiography for the evaluation of circle of Willis, posterior circulation, and aortic arch architecture...
April 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28321471/feasibility-of-in-vivo-18-f-florbetaben-pet-mr-imaging-of-human-carotid-amyloid-%C3%AE
#2
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse, Hermann-Josef Gertz, Erik A L Biessen, Felix M Mottaghy, Osama Sabri
PURPOSE: Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. (18)F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer's disease (AD). We sought to determine whether specific uptake of (18)F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with clinical cardiovascular disease (CVD) risk factors. METHODS: Carotid (18)F-florbetaben uptake was quantified as the mean of the maximum target-to-background ratio (meanTBRmax) in 40 cognitively impaired subjects (age 68...
March 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28216518/optimization-of-t1-weighted-imaging-parameters-in-mr-carotid-plaque-imaging-influence-for-the-quantitative-evaluation-among-different-mri-scanner-types
#3
Takanori Naka, Mitsuyuki Takahashi, Koutarou Takeda, Tarou Igarashi, Tetsukazu Hondera
Carotid artery plaques with high-signal intensity on T1 weighted image (T1 WI) are known to cause cerebral ischemic disease. Signal intensity ratio (SIR), which is calculated from T1 WI in the quantitative evaluation of plaque characterization have been used. However, the various sequences in T1 WI and difference in the sequences were utilized among institutions. Therefore, difference in sequence may influence SIR. The purpose of this study was to evaluate the optimization of T1 WI sequence in MR carotid plaque imaging...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#4
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27851995/key-clinical-benefits-of-neuroimaging-at-7t
#5
Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7T, is related to improved clinical results with regard to morphological as well as functional and metabolic capabilities. Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7T is to gain higher spatial resolution in the brain compared to 3T. Of specific clinical interest for neuro applications is the cerebral cortex at 7T, for the detection of changes in cortical structure, like the visualization of cortical microinfarcts and cortical plaques in Multiple Sclerosis...
November 13, 2016: NeuroImage
https://www.readbyqxmd.com/read/27801780/preoperative-3d-fse-t1-weighted-mr-plaque-imaging-for-severely-stenotic-cervical-ica-accuracy-of-predicting-emboli-during-carotid-endarterectomy
#6
Yasushi Ogasawara, Yuiko Sato, Shinsuke Narumi, Makoto Sasaki, Shunrou Fujiwara, Masakazu Kobayashi, Kenji Yoshida, Yasuo Terayama, Kuniaki Ogasawara
The aim of the present study was to determine whether preoperative three-dimensional (3D) fast spin-echo (FSE) T1-weighted magnetic resonance (MR) plaque imaging for severely stenotic cervical carotid arteries could accurately predict the development of artery-to-artery emboli during exposure of the carotid arteries in carotid endarterectomy (CEA). Seventy-five patients underwent preoperative MR plaque imaging and CEA under transcranial Doppler ultrasonography of the ipsilateral middle cerebral artery. On reformatted axial MR image slices showing the maximum plaque occupation rate (POR) and maximum plaque intensity for each patient, the contrast ratio (CR) was calculated by dividing the internal carotid artery plaque signal intensity by the sternocleidomastoid muscle signal intensity...
October 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27100539/-simultaneous-magnetic-resonance-angiographic-and-tomographic-assessment-of-atherosclerotic-plaques-of-carotid-arteries-with-paramagnetic-contrasting-by-cyclomang
#7
V Yu Usov, M L Belyanin, E E Bobrikova, O Yu Borodin, N L Shimanovsky, T V Minenko, I L Bukhovets, M P Plotnikov, B N Kozlov, V M Shipulin
The authors studied a possibility of simultaneously performing magnetic resonance (MR) angiography of carotid arteries and contrast-enhanced MR tomography of atherosclerotic plaques of carotid arteries. We examined a total of 16 patients presenting with disseminated atherosclerosis and 8 patients of the control group. Quadrature coils for examination of the head were used in order to sequentially perform MR tomography of the brain, MR angiography of carotid arteries and MR tomography of atherosclerotic plaques of carotid arteries with contrasting by 0...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27080075/value-of-higher-resolution-mri-in-assessing-middle-cerebral-atherosclerosis-and-predicting-capsular-warning-syndrome
#8
Xin Xu, Yafen Wei, Xiandong Zhang, Lili Yang, Zhitang Cui, Junjie Yan
PURPOSE: To investigate the correlation between middle cerebral atherosclerosis and capsular warning syndrome (CWS) and assess the value of higher-resolution magnetic resonance imaging (MRI) in prognostication. MATERIALS AND METHODS: In all, 97 transient ischemic attack (TIA) patients who underwent an MRI from February 2010 to December 2013 were included in the retrospective study and divided into either a CWS or middle cerebral artery (MCA) TIA group according to their eventual clinical diagnosis...
November 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26846926/optimal-mr-plaque-imaging-for-cervical-carotid-artery-stenosis-in-predicting-the-development-of-microembolic-signals-during-exposure-of-carotid-arteries-in-endarterectomy-comparison-of-4-t1-weighted-imaging-techniques
#9
Y Sato, K Ogasawara, S Narumi, M Sasaki, A Saito, E Tsushima, T Namba, M Kobayashi, K Yoshida, Y Terayama, A Ogawa
BACKGROUND AND PURPOSE: Preoperative identification of plaque vulnerability may allow improved risk stratification for patients considered for carotid endarterectomy. The present study aimed to determine which plaque imaging technique, cardiac-gated black-blood fast spin-echo, magnetization-prepared rapid acquisition of gradient echo, source image of 3D time-of-flight MR angiography, or noncardiac-gated spin-echo, most accurately predicts development of microembolic signals during exposure of carotid arteries in carotid endarterectomy...
June 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26542236/associations-between-cerebral-embolism-and-carotid-intraplaque-hemorrhage-during-protected-carotid-artery-stenting
#10
G H Chung, J Y Jeong, H S Kwak, S B Hwang
BACKGROUND AND PURPOSE: Carotid artery stent placement in patients with intraplaque hemorrhage remains controversial because of the incidence of cerebral embolism after the procedure. The purpose of this study is to determine if intraplaque hemorrhage is a significant risk factor for cerebral embolism during carotid artery stent placement. MATERIALS AND METHODS: This prospective study assessed 94 consecutive patients with severe carotid stenosis. These patients underwent preprocedural carotid MR imaging and postprocedural DWI after carotid artery stent placement...
April 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26539508/middle-cerebral-artery-atherosclerotic-plaques-in-recent-small-subcortical-infarction-a-three-dimensional-high-resolution-mr-study
#11
Xiao-Dong Zou, Yiu-Cho Chung, Lei Zhang, Ying Han, Qi Yang, Jianping Jia
PURPOSE: Conventional two-dimensional vessel wall imaging has been used to depict the middle cerebral artery (MCA) wall in patients with recent small subcortical infarctions (RSSIs). However, its clinical use has been limited by restricted spatial coverage, low signal-to-noise ratio (SNR), and long scan time. We used a novel three-dimensional high-resolution MR imaging (3D HR-MRI) technique to investigate the presence, locations, and contrast-enhanced patterns of MCA plaques and their relationship with RSSI...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26251417/quantification-of-%C3%AE-amyloidosis-and-rcbf-with-dedicated-pet-7-t-mr-imaging-and-high-resolution-microscopic-mr-imaging-at-16-4-t-in-app23-mice
#12
Florian C Maier, Marianne D Keller, Daniel Bukala, Benjamin Bender, Julia G Mannheim, Ian M Brereton, Graham J Galloway, Bernd J Pichler
UNLABELLED: We present a combined PET/7 T MR imaging and 16.4 T microscopic MR imaging dual-modality imaging approach enabling quantification of the amyloid load at high sensitivity and high resolution, and of regional cerebral blood flow (rCBF) in the brain of transgenic APP23 mice. Moreover, we demonstrate a novel, voxel-based correlative data analysis method for in-depth evaluation of amyloid PET and rCBF data. METHODS: We injected 11C-Pittsburgh compound B (PIB) intravenously in transgenic and control APP23 mice and performed dynamic PET measurements...
October 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26143482/high-resolution-three-dimensional-intracranial-arterial-wall-imaging-at-3-t-using-t1-weighted-space
#13
Lei Zhang, Na Zhang, Jun Wu, Lijuan Zhang, Yanyan Huang, Xin Liu, Yiu-Cho Chung
OBJECTIVE: To study the effect of imaging parameters on the contrast of T1 weighted SPACE (Sampling Perfection with Application optimized Contrast using different angle Evolutions, a 3D TSE variant) at 3 T for high resolution imaging of intracranial plaques before contrast and with post-gadolinium induced enhancement, and evaluate its relevance to patients with intracranial atherosclerosis. MATERIALS AND METHODS: Optimized parameters giving good T1 contrast between intracranial vessel wall and cerebrospinal fluid within a specific scan time and reasonable coverage were found by simulation and validated in a healthy volunteer study...
November 2015: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/26063590/plasma-homocysteine-levels-predict-the-risk-of-acute-cerebral-infarction-in-patients-with-carotid-artery-lesions
#14
Wei Wu, Yi Guan, Kan Xu, Xi-Jia Fu, Xiao-Feng Lei, Li-Jian Lei, Zhi-Qing Zhang, Yan Cheng, Yun-Qian Li
This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 umol/L). High-resolution B-mode ultrasounds were performed to assess intima media thickness (IMT), infarcts, plaques, and stenosis in the extracranial carotid artery of these patients. All patients underwent 3 T MR scanners to evaluate cerebral artery stenosis in the intracranial cerebral artery...
May 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/25949852/meningiomatosis-restricted-to-the-left-cerebral-hemisphere-with-acute-clinical-deterioration-case-presentation-and-discussion-of-treatment-options
#15
Victoria Ohla, Christian Scheiwe
BACKGROUND: True multiple meningiomas are defined as meningiomas occurring at several intracranial locations simultaneously without the presence of neurofibromatosis. Though the prognosis does not differ from benign solitary meningiomas, the simultaneous occurrence of different grades of malignancy has been reported in one-third of patients with multiple meningiomas. Due to its rarity, unclear etiology, and questions related to proper management, we are presenting our case of meningiomatosis and discuss possible pathophysiological mechanisms...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/25929881/vascular-wall-imaging-of-unruptured-cerebral-aneurysms-with-a-hybrid-of-opposite-contrast-mr-angiography
#16
T Matsushige, Y Akiyama, T Okazaki, K Shinagawa, N Ichinose, K Awai, K Kurisu
BACKGROUND AND PURPOSE: Inflammation and degeneration of the intracranial saccular aneurysm wall play a major role in aneurysm formation, development and subsequent rupture. The aim of this study was to characterize the walls of unruptured intracranial aneurysms by using a hybrid of opposite-contrast MRA at 3T. MATERIALS AND METHODS: Fourteen consecutive patients with 17 unruptured intracranial aneurysms who initially underwent clipping surgery were prospectively evaluated...
August 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/25915709/distribution-and-features-of-middle-cerebral-artery-atherosclerotic-plaques-in-symptomatic-patients-a-3-0%C3%A2-t-high-resolution-mri-study
#17
Binbin Sui, Peiyi Gao, Yan Lin, Lina Jing, Haiqiang Qin
OBJECTIVES: To investigate the distribution and features of middle cerebral artery (MCA) atherosclerotic plaques in patients with acute ischaemic strokes using high-resolution magnetic resonance (MR) imaging. METHODS: Forty-six plaques from 44 MCAs (18 right and 26 left) in patients with acute symptomatic ischaemic strokes were studied. High-resolution MR imaging including tb1 weighted imaging (T1WI), tb2 weighted imaging (T2WI), PD weighted imaging (PDWI) and three-dimensional magnetization-prepared rapid acquisition gradient-echo (MPRAGE) sequences were used to visualise the plaques...
May 2015: Neurological Research
https://www.readbyqxmd.com/read/25762432/clinical-applications-at-ultrahigh-field-7%C3%A2-%C3%A2-t-where-does-it-make-the-difference
#18
REVIEW
Siegfried Trattnig, Wolfgang Bogner, Stephan Gruber, Pavol Szomolanyi, Vladimir Juras, Simon Robinson, Štefan Zbýň, Stefan Haneder
Presently, three major MR vendors provide commercial 7-T units for clinical research under ethical permission, with the number of operating 7-T systems having increased to over 50. This rapid increase indicates the growing interest in ultrahigh-field MRI because of improved clinical results with regard to morphological as well as functional and metabolic capabilities. As the signal-to-noise ratio scales linearly with the field strength (B0 ) of the scanner, the most obvious application at 7 T is to obtain higher spatial resolution in the brain, musculoskeletal system and breast...
September 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/25747345/clinical-and-imaging-features-associated-with-an-increased-risk-of-early-and-late-stroke-in-patients-with-symptomatic-carotid-disease
#19
REVIEW
A R Naylor, H Sillesen, T V Schroeder
OBJECTIVE: The aim of this review was to identify clinical and/or imaging parameters that are associated with an increased (decreased) risk of early/late stroke in patients with symptomatic carotid disease. IN THE FIRST 14 DAYS: Natural history studies suggest that 8-15% of patients with 50-99% stenoses will suffer a stroke within 72 hours of their index symptom. Currently, there are insufficient validated data to identify highest-risk patients for emergency carotid endarterectomy (CEA), but an increased risk of stroke appears to be predicted by (i) an ABCD(2) score of 4-7; (ii) the presence of acute cerebral injury on CT/MRI; (iii) Gray Scale Median (GSM) <15, (iv) spontaneous embolisation on Transcranial Doppler (TCD); and (v) increased fluorodeoxyglucose (FDG) uptake in the carotid plaque on positron emission tomography (PET)...
May 2015: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/25549640/-arterial-remodeling-in-middle-cerebral-artery-atherosclerotic-stenosis-a-high-resolution-mri-study
#20
Dengling Zhao, Gaojun Teng, Xiaohui Chen, Shenghong Ju, Gang Deng, Min Wang, Qinghai Zhang, Haimei Zhang, Zhaorui Hou
OBJECTIVE: To investigate remodeling mode of moderate or severe atherosclerotic stenosis of the middle cerebral artery (MCA) using high resolution MRI. METHODS: Thirty-seven consecutive symptomatic patients with atherosclerotic MCA stenosis were imaged with a 3.0-T magnetic resonance scanner. The HR-MRI protocol included four different scans: T1-weighted black blood imaging, T2-weighted MR, proton density (PD)-weighted MR, and 3D-SPACE. The wall area (VA), lumen area (LA) and plaque area (PA) were calculated...
October 14, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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