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https://www.readbyqxmd.com/read/28649892/are-we-exaggerating-neuropsychological-impairment-in-depression-reopening-a-closed-chapter
#1
Steffen Moritz, Katrin Stöckert, Marit Hauschildt, Hannah Lill, Lena Jelinek, Thomas Beblo, Sabrina Diedrich, Sönke Arlt
BACKGROUND: Meta-analyses conclude that individuals with depression display neurocognitive deficits. However, the extent to which some of these impairments occur due to secondary influences, and thus in part represent epiphenomena, has rarely been tested. Therefore, the authors examined the impact of performance motivation, attitude towards cognitive assessment, and momentary symptoms during assessment on neuropsychological test results in depression. RESEARCH DESIGN AND METHODS: Forty-five patients with depression and 60 nonclinical individuals underwent a comprehensive neuropsychological test battery...
June 26, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28649849/toward-establishing-a-standard-symptom-set-for-assessing-sluggish-cognitive-tempo-in-children-evidence-from-teacher-ratings-in-a-community-sample
#2
Stephen P Becker, G Leonard Burns, Aidan P Schmitt, Jeffery N Epstein, Leanne Tamm
Despite increasing interest in sluggish cognitive tempo (SCT) in children, the field is stymied by the lack of a standard symptom set that can be used across studies. Without a standard symptom set, it is difficult to determine if differences across studies are due to methodological or sample differences, or simply the way SCT was measured. To move the field toward a standard symptom set, this study evaluates a teacher-report rating scale of SCT revised based on recent meta-analytic findings that identified optimal items for distinguishing SCT from attention-deficit/hyperactivity disorder inattention (ADHD-IN)...
June 1, 2017: Assessment
https://www.readbyqxmd.com/read/28649630/towards-human-exploration-of-space-the-theseus-review-series-on-muscle-and-bone-research-priorities
#3
Thomas Lang, Jack J W A Van Loon, Susan Bloomfield, Laurence Vico, Angele Chopard, Joern Rittweger, Antonios Kyparos, Dieter Blottner, Ilkka Vuori, Rupert Gerzer, Peter R Cavanagh
Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649493/voluntary-saccade-inhibition-deficits-correlate-with-extended-white-matter-cortico-basal-atrophy-in-huntington-s-disease
#4
Israel Vaca-Palomares, Brian C Coe, Donald C Brien, Douglas P Munoz, Juan Fernandez-Ruiz
The ability to inhibit automatic versus voluntary saccade commands in demanding situations can be impaired in neurodegenerative diseases such as Huntington's disease (HD). These deficits could result from disruptions in the interaction between basal ganglia and the saccade control system. To investigate voluntary oculomotor control deficits related to the cortico-basal circuitry, we evaluated early HD patients using an interleaved pro- and anti-saccade task that requires flexible executive control to generate either an automatic response (look at a peripheral visual stimulus) or a voluntary response (look away from the stimulus in the opposite direction)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28649302/differential-predictors-of-dsm-5-ptsd-and-icd-11-complex-ptsd-among-african-american-women
#5
Abigail Powers, Negar Fani, Sierra Carter, Dorthie Cross, Marylene Cloitre, Bekh Bradley
Background: Complex posttraumatic stress disorder (CPTSD) is proposed for inclusion in the ICD-11 as a diagnosis distinct from posttraumatic stress disorder (PTSD), reflecting deficits in affective, self-concept, and relational domains. There remains significant controversy over whether CPTSD provides useful diagnostic information beyond PTSD and other comorbid conditions, such as depression or substance use disorders. Objective: The present study examined differences in psychiatric presentation for three groups: traumatized controls, DSM-5 PTSD subjects, and ICD-11 CPTSD subjects...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28649283/clinically-evident-tophi-are-associated-with-reduced-muscle-force-in-the-foot-and-ankle-in-people-with-gout-a-cross-sectional-study
#6
Sarah Stewart, Nicola Dalbeth, Simon Otter, Peter Gow, Sunil Kumar, Keith Rome
BACKGROUND: The foot and ankle represent a common site for tophi in people with gout, yet it is unclear whether the presence of tophi is related to impaired muscle function. This study aimed to determine the association between foot and ankle tophi and muscle force in people with gout. METHODS: Participants with gout were stratified into two groups based on the presence of clinically-evident tophi affecting the foot or ankle on physical examination. Isometric muscle force for plantarflexion, dorsiflexion, inversion and eversion was measured using static dynamometry...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28649208/the-four-causes-of-adhd-aristotle-in-the-classroom
#7
Marino Pérez-Álvarez
Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most well-established and at the same time controversial disorders to the extreme of being placed in doubt. In the first of two parts, the established position is critically reviewed, beginning with showing fallacious reasoning on which the diagnosis is based, lacking clinical proof. Similarly, a certain rhetoric and metaphysics in genetic and neurobiological research is highlighted, where, for example, a meager accumulation of data is offered as robust conclusions, and correlates and correlations as causes and bases...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28649193/repeated-low-intensity-blast-exposure-is-associated-with-damaged-endothelial-glycocalyx-and-downstream-behavioral-deficits
#8
Aaron A Hall, Mirian I Mendoza, Hanbing Zhou, Michael Shaughness, Eric Maudlin-Jeronimo, Richard M McCarron, Stephen T Ahlers
Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests that the vasculature plays a key role in the pathology. This study used a rat model to examine whether the endothelial glycocalyx, a layer of the vasculature responsible for sensing luminal shear forces, is damaged by exposure to repeated low intensity blast, and whether this layer is associated with observed behavioral deficits...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28649192/deleterious-effects-of-chronic-folate-deficiency-in-the-ts65dn-mouse-model-of-down-syndrome
#9
Susan Helm, Morgan Blayney, Taylor Whited, Mahjabin Noroozi, Sen Lin, Semira Kern, David Green, Ahmad Salehi
Folate is an important B vitamin naturally found in the human diet and plays a critical role in methylation of nucleic acids. Indeed, abnormalities in this major epigenetic mechanism play a pivotal role in the pathogenesis of cognitive deficit and intellectual disability in humans. The most common cause of cognitive dysfunction in children is Down syndrome (DS). Since folate deficiency is very common among the pediatric population, we questioned whether chronic folate deficiency (CFD) exacerbates cognitive dysfunction in a mouse model of DS...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28649011/comparison-of-techniques-to-determine-human-skeletal-muscle-voluntary-activation
#10
Anastasia Zarkou, Scott Stackhouse, Stuart A Binder-Macleod, Samuel C K Lee
Determining volitional activation (VA) can provide insights on the cause of muscle weakness in orthopedic and neurological populations. Two electrical stimulation techniques are traditionally used to quantify VA: interpolation (IT) and superimposition (CAR). IT allows for a more accurate VA estimation, however it requires individuals to be stimulated twice, compared to once for CAR, and thus increases stimulation associated discomfort. To date, there is no agreement on what is the best practical technique for calculating quadriceps VA...
June 8, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28648915/long-term-course-of-negative-symptom-subdomains-and-relationship-with-outcome-in-patients-with-a-psychotic-disorder
#11
Annemarie P M Stiekema, Md Atiqul Islam, Edith J Liemburg, Stynke Castelein, Edwin R van den Heuvel, Jaap van Weeghel, André Aleman, Richard Bruggeman, Lisette van der Meer
BACKGROUND: The longitudinal course of the negative symptoms subdomains social amotivation (SA) and expressive deficits (ED) remains largely unknown. We investigated i) the longitudinal course of SA and ED subdomain scores, ii) whether subgroups based on the course of SA and ED subdomain scores could be identified, iii) whether baseline SA and ED subdomain scores were related to functioning and quality of life six years later and iv) the longitudinal relationship between subgroups and outcomes...
June 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28648115/complete-thoracolumbar-fracture-dislocation-with-intact-neurologic-function-explanation-of-a-novel-cord-saving-mechanism
#12
Abolfazl Rahimizadeh, Naser Asgari, Ava Rahimizadeh
BACKGROUND: The thoracolumbar junction from T11 to L2 is a common site of injury in which fracture and dislocations are the most prevalent ones occurring at this location. Fracture dislocation is defined as failure of all three columns of the spine with gross displacement. Considering the significant violence necessary to produce fracture dislocations, these injuries are often associated with major neural deficit, with the majority of casualties becoming paraplegic immediately. Preservation of neurological function following complete fracture dislocation is quite rare entity...
June 26, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28647815/update-on-the-epidemiology-diagnosis-and-treatment-of-mania-in-older-age-bipolar-disorder
#13
REVIEW
Peijun Chen, Annemiek Dols, Soham Rej, Martha Sajatovic
PURPOSE OF REVIEW: The population over age 60 is growing more rapidly than the general population. Given the projected increase and need for data that can inform treatment, this review provides a brief description of newer publications focused on mania in older-age bipolar disorder (OABD), including epidemiology, diagnosis, and treatments. RECENT FINDINGS: Age cutoffs to define OABD range from 50 to 65 years. OABD clinical presentation and course of illness is highly variable, often characterized by mood episode recurrence, medical comorbidity, cognitive deficits, and impaired functioning...
August 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28647013/autism-spectrum-symptoms-in-a-tourette-s-disorder-sample
#14
Sabrina M Darrow, Marco Grados, Paul Sandor, Matthew E Hirschtritt, Cornelia Illmann, Lisa Osiecki, Yves Dion, Robert King, David Pauls, Cathy L Budman, Danielle C Cath, Erica Greenberg, Gholson J Lyon, William M McMahon, Paul C Lee, Kevin L Delucchi, Jeremiah M Scharf, Carol A Mathews
OBJECTIVE: Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). METHOD: Participants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms...
July 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28647009/teenage-parenthood-and-birth-rates-for-individuals-with-and-without-attention-deficit-hyperactivity-disorder-a-nationwide-cohort-study
#15
Søren D Østergaard, Søren Dalsgaard, Stephen V Faraone, Trine Munk-Olsen, Thomas M Laursen
OBJECTIVE: Prior studies have established that attention-deficit/hyperactivity disorder (ADHD) is associated with risky sexual behavior, but it remains unknown whether individuals with ADHD also are more likely to become parents while being teenagers. This aspect is clinically relevant because teenage parenthood is associated with adverse outcomes for parents and children. Therefore, the main aim of this study was to investigate whether individuals with ADHD would be more likely to become teenage parents compared with individuals without ADHD...
July 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28645984/facilitators-and-barriers-to-participation-of-private-sector-health-facilities-in-government-led-schemes-for-maternity-services-in-india-a-qualitative-study
#16
Vikas Yadav, Somesh Kumar, Sudharsanam Balasubramaniam, Ashish Srivastava, Suranjeen Pallipamula, Parvez Memon, Dinesh Singh, Saurabh Bhargava, Greeshma Ann Sunil, Bulbul Sood
OBJECTIVE: Despite provision of accreditation of private sector health providers in government-led schemes for maternity services in India, their participation has been low. This has led to an underutilisation of their presence, resources and expertise for providing quality maternal and newborn health services. This study explores the perception of various stakeholders on expectations, benefits, barriers and facilitators to private sector participation in government-led schemes-specifically Janani Suraksha Yojana (JSY)-for maternity service delivery...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28644998/olfactory-identification-deficit-predicts-white-matter-tract-impairment-in-alzheimer-s-disease
#17
Matthew R Woodward, Michael G Dwyer, Niels Bergsland, Jesper Hagemeier, Robert Zivadinov, Ralph Hb Benedict, Kinga Szigeti
Olfactory identification deficit (OID) has been associated with both aging and Alzheimer's disease (AD). In the context of an amnestic disorders, OID predicts conversion to AD. Neuroanatomical correlates could increase specificity and sensitivity and elucidate the mechanistic differences between OID in AD and aging. Cross-sectional analysis of white matter microstructural changes was performed using diffusion tensor imaging (DTI) and tract-based-spatial-statistics in amnestic mild cognitive impairment (aMCI), AD and normal controls (NC) in 66 subjects (26 AD, 15 aMCI, 25 NC)...
June 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644064/frequent-vomiting-attacks-in-a-patient-with-lhermitte-duclos-disease-a-rare-pathophysiology-of-cerebellar-lesions
#18
Chika Somagawa, Tomonori Ono, Ryoko Honda, Hiroshi Baba, Takeshi Hiu, Ryujiro Ushijima, Keisuke Toda, Kei Sato, Masahiro Ito, Keisuke Tsutsumi
Lhermitte-Duclos disease (LDD) is a neurological disease caused by a hamartomatous lesion in the cerebellum. Clinically, LDD is commonly associated with progressive space-occupying lesion effects in the posterior fossa, increasing intracranial pressure, occlusive hydrocephalus, and focal neurological deficits of adjacent structures. The authors report the case of a 10-year-old boy with LDD who had been suffering from vomiting attacks (VAs). These VAs had been brief in duration but extremely frequent, and they had been resistant to antiemetic drugs since the early postnatal period...
June 23, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28643234/body-mass-disorders-in-healthy-short-children-and-in-children-with-growth-hormone-deficiency
#19
Paweł Tomaszewski, Katarzyna Milde, Anna Majcher, Beata Pyrżak, Gul Tiryaki-Sonmez, Brad J Schoenfeld
The aim of the study was to determine the degree of adiposity and the incidence of body mass disorders, including abdominal obesity, in healthy short children and children with growth hormone deficiency. The study included 134 short children (height < 10th percentile) aged 7-15. In this cohort there were 63 (31 boys and 32 girls) children without diagnosed hormonal disorders and 71 patients (35 boys and 36 girls) with growth hormone deficiency. Basic somatic features were assessed and the study participants were categorized according to the percentage of body fat (%FAT), body mass index (BMI), and waist-to-height ratio (WHtR)...
June 23, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28642699/cerebral-blood-flow-and-amyloid-%C3%AE-interact-to-affect-memory-performance-in-cognitively-normal-older-adults
#20
Katherine J Bangen, Alexandra L Clark, Emily C Edmonds, Nicole D Evangelista, Madeleine L Werhane, Kelsey R Thomas, Lyzette E Locano, My Tran, Zvinka Z Zlatar, Daniel A Nation, Mark W Bondi, Lisa Delano-Wood
Cerebral blood flow (CBF) alterations and amyloid-β (Aβ) accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential statistical interactions between CBF and Aβ status in regions typically affected in Alzheimer's disease (AD) within a sample of older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Sixty-two cognitively normal participants (mean age = 72 years) underwent neuroimaging and memory testing...
2017: Frontiers in Aging Neuroscience
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