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https://www.readbyqxmd.com/read/28622525/atm-atr-and-dna-pk-the-trinity-at-the-heart-of-the-dna-damage-response
#1
REVIEW
Andrew N Blackford, Stephen P Jackson
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities and common mechanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health...
June 15, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28601440/a-transcriptomic-resource-for-the-northern-krill-meganyctiphanes-norvegica-based-on-a-short-term-temperature-exposure-experiment
#2
Leocadio Blanco-Bercial, Amy E Maas
The northern krill, Meganyctiphanes norvegica, is an important component of the pelagic food web across the North Atlantic. Widespread from the Mediterranean to the Subarctic Atlantic, populations appear to be strongly adapted to local temperatures, and seem to have very little plasticity. The goal of this study was to create and annotate a de novo transcriptome assembly to allow for comparative and physiological studies and to explore the gene expression response of M. norvegica from the Gulf of Maine to two different temperature conditions...
June 7, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28597078/spectrum-of-genetic-mutations-in-de-novo-punlmp-of-the-urinary-bladder
#3
Maria Del Carmen Rodriguez Pena, Aline C Tregnago, Marie-Lisa Eich, Simeon Springer, Yuxuan Wang, Diana Taheri, Dilek Ertoy, Kazutoshi Fujita, Stephania M Bezerra, Isabela W Cunha, Maria Rosaria Raspollini, Lijia Yu, Trinity J Bivalacqua, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, George J Netto
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60-80% of urothelial carcinomas and some of their histologic variants. Five other genes have been frequently implicated in bladder cancer: FGRF3, TP53, PIK3CA, HRAS, and CDKN2A. In the current study, we sought to determine the prevalence of mutations in TERT and these five other genes in de novo papillary urothelial neoplasms of low malignant potential (PUNLMP) of the urinary bladder. A retrospective search of our archives for PUNLMP was performed and 30 de novo cases were identified and included in the study...
June 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28589829/royal-trinity-hospice
#4
(no author information available yet)
Royal Trinity Hospice in south London has developed an app to help patients and carers navigate palliative care and access the support available to them.
June 7, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28588015/intravesical-bcg-induces-cd4-t-cell-expansion-in-an-immune-competent-model-of-bladder-cancer
#5
Max Kates, Thomas Nirschl, Nikolai A Sopko, Hotaka Matsui, Christina M Kochel, Leonardo O Reis, George J Netto, Mohammad Hoque, Noah M Hahn, David J McConkey, Alex S Baras, Charles G Drake, Trinity J Bivalacqua
Intravesical BCG immunotherapy is the standard of care in treating non-muscle invasive bladder cancer, yet its mechanism of action remains elusive.  Both innate and adaptive immune responses have been implicated in BCG activity. Although prior research has indirectly demonstrated the importance of T cells and shown a rise in CD4(+) T cells in bladder tissue after BCG, T-cell subpopulations have not been fully characterized.  We investigated the relationship between effector and regulatory T cells in an immune competent, clinically relevant rodent model of bladder cancer...
June 6, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28567408/evidence-based-adaptation-and-scale-up-of-a-mobile-phone-health-information-service
#6
Kelly L'Engle, Kate F Plourde, Trinity Zan
BACKGROUND: The research base recommending the use of mobile phone interventions for health improvement is growing at a rapid pace. The use of mobile phones to deliver health behavior change and maintenance interventions in particular is gaining a robust evidence base across geographies, populations, and health topics. However, research on best practices for successfully scaling mHealth interventions is not keeping pace, despite the availability of frameworks for adapting and scaling health programs...
2017: MHealth
https://www.readbyqxmd.com/read/28559923/prevalence-and-risk-factors-associated-with-sexually-transmitted-infections-stis-among-women-of-reproductive-age-in-swaziland
#7
Themba G Ginindza, Cristina D Stefan, Joyce M Tsoka-Gwegweni, Xolisile Dlamini, Pauline E Jolly, Elisabete Weiderpass, Nathalie Broutet, Benn Sartorius
BACKGROUND: Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. Epidemiological data on STIs among women of reproductive age in Swaziland are limited. The availability of epidemiological data on STIs and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. The study aimed to determine the prevalence and risk factors associated with STIs...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28553331/rhoa-rock-activation-in-major-pelvic-ganglion-mediates-caspase-3-dependent-nitrergic-neuronal-apoptosis-following-cavernous-nerve-injury
#8
Michael Bell, Nikolai A Sopko, Hotaka Matsui, Johanna L Hannan, Trinity J Bivalacqua
No abstract text is available yet for this article.
April 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28545860/de-novo-transcriptome-assembly-and-annotation-for-the-desert-rainbowfish-melanotaenia-splendida-tatei-with-comparison-with-candidate-genes-for-future-climates
#9
Katie Gates, Jonathan Sandoval-Castillo, Louis Bernatchez, Luciano B Beheregaray
Transcriptomics via RNA-seq has rapidly emerged as a powerful tool for ecological and evolutionary studies, enabling genome-scale studies of adaptation via regulation of global gene expression. Here we present a de novo transcriptome for the desert rainbowfish (Melanotaenia splendida tatei) based on individuals sampled in the Lake Eyre Basin, Australia's arid zone river system. Recently developed methods in RNA-seq and bioinformatics were used for sequencing, assembling and annotating a high-quality liver transcriptome suitable for studies of ecology and adaptation in desert rainbowfish...
May 22, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28502716/neuropeptides-predicted-from-the-transcriptome-analysis-of-the-gray-garden-slug-deroceras-reticulatum
#10
Seung-Joon Ahn, Ruth Martin, Sujaya Rao, Man-Yeon Choi
The gray garden slug, Deroceras reticulatum (Gastropoda: Pulmonata), is one of the most common terrestrial molluscs. Research for this slug has focused mainly on its ecology, biology, and management due to the severe damage it causes on a wide range of vegetables and field crops. However, little is known about neuropeptides and hormonal signalings. This study, therefore, aimed to establish the transcriptome of D. reticulatum and to identify a comprehensive repertoire of neuropeptides in this slug. Illumina high-throughput sequencing of the whole body transcriptome of D...
May 11, 2017: Peptides
https://www.readbyqxmd.com/read/28490600/something-is-definitely-better-than-nothing-simple-strategies-to-prevent-vascular-dysfunction
#11
Joel D Trinity
Understanding the negative health consequences of a physical inactivity has been the topic of much investigation as an alarming number of adults have adopted a sedentary lifestyle. With the rise in sedentarism the field of inactivity physiology has emerged. The goal of inactivity physiology is to identify the impact in inactivity on health and develop strategies that effectively minimize the risk of a sedentary lifestyle. Arising from this field is the finding that excessive sitting is linked to increased cardiovascular and metabolic disease and all-cause mortality...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28486811/characterizing-the-noble-gas-isotopic-composition-of-the-barnett-shale-and-strawn-group-and-constraining-the-source-of-stray-gas-in-the-trinity-aquifer-north-central-texas
#12
Tao Wen, M Clara Castro, Jean-Philippe Nicot, Chris M Hall, Daniele L Pinti, Patrick Mickler, Roxana Darvari, Toti Larson
This study presents the complete set of stable noble gases for Barnett Shale and Strawn Group production gas together with stray flowing gas in the Trinity Aquifer, Texas. It places new constraints on the source of this stray gas and further shows that Barnett and Strawn gas have distinct crustal and atmospheric noble gas signatures, allowing clear identification of these two sources. Like stray gas, Strawn gas is significantly more enriched in crustal (4)He*, (21)Ne*, and (40)Ar* than Barnett gas. The similarity of Strawn and stray gas crustal noble gas signatures suggests that the Strawn is the source of stray gas in the Trinity Aquifer...
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28480168/port-site-recurrence-following-a-robotic-laparoscopic-radical-nephroureterectomy-for-sarcomatoid-variant-of-urothelial-carcinoma
#13
Jonathan Elliott Katz, Trinity J Bivalacqua, Noah M Hahn, Nikolai A Sopko
Port Site Recurrence (PSR) following laparoscopic tumor resections has been reported for a variety of tumors. Though PSR is a rare phenomenon, they most commonly occur following nephroureterectomies for upper tract urothelial carcinoma. Herein we report a novel case of a PSR following a robotic assisted nephroureterectomy for the sarcomatoid variant of urothelial carcinoma of the upper urinary tract.
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28476535/animal-models-of-pain-and-migraine-in-drug-discovery
#14
REVIEW
Gordon Munro, Inger Jansen-Olesen, Jes Olesen
Preclinical research activities in relation to pain typically involve the 'holy trinity' of nociceptive, inflammatory and neuropathic pain for purposes of target validation and defining target product profiles of novel analgesic compounds. For some reason it seems that headache or migraine are rarely considered as additional entities to explore. Frontline medications used in the treatment of, for example, inflammatory pain, neuropathic pain and migraine (NSAIDs versus pregabalin/duloxetine versus triptans) reveal distinct differences in pathophysiology that partially explain this approach...
May 2, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28473714/a-2-oxa-spiro-5-4-decane-scaffold-displays-neurotrophic-neurogenic-and-anti-neuroinflammatory-activities-with-high-potential-for-development-as-a-versatile-cns-therapeutic
#15
Pranav Chintamani Joshi, Ramesh Samineni, Dwaipayan Bhattacharya, Bommana Raghunath Reddy, Lenin Veeraval, Tapatee Das, Swati Maitra, Abhipradnya Bipin Wahul, Shailaja Karri, Srihari Pabbaraja, Goverdhan Mehta, Arvind Kumar, Sumana Chakravarty
Following our recent discovery of a new scaffold exhibiting significant neurotrophic and neurogenic activities, a structurally tweaked analogue, embodying a 2-oxa-spiro [5.4]decane framework, has been conceptualised and found to be more potent and versatile. It exhibits enhanced neurotrophic and neurogenic action in in vitro, ex vivo and in vivo models and also shows robust neuroprotection in mouse acute cerebral stroke model. The observed attributes are traceable to the predominant activation of the TrkB-PI3K-AKT-CREB pathway...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28464849/transcriptome-analysis-of-smut-fungi-reveals-widespread-intergenic-transcription-and-conserved-antisense-transcript-expression
#16
Michael E Donaldson, Lauren A Ostrowski, Kristi M Goulet, Barry J Saville
BACKGROUND: Biotrophic fungal plant pathogens cause billions of dollars in losses to North American crops annually. The model for functional investigation of these fungi is Ustilago maydis. Its 20.5 Mb annotated genome sequence has been an excellent resource for investigating biotrophic plant pathogenesis. Expressed-sequence tag libraries and microarray hybridizations have provided insight regarding the type of transcripts produced by U. maydis but these analyses were not comprehensive and there were insufficient data for transcriptome comparison to other smut fungi...
May 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28464067/transcriptomic-analysis-of-l-roots-during-the-early-infection-process
#17
Jaime Jiménez-Ruiz, María de la O Leyva-Pérez, Elisabetta Schilirò, Juan Bautista Barroso, Aureliano Bombarely, Lukas Mueller, Jesús Mercado-Blanco, Francisco Luque
Olive cultivation is affected by a wide range of biotic constraints. Verticillium wilt of olive is one of the most devastating diseases affecting this woody crop, inflicting major economic losses in many areas, particularly within the Mediterranean Basin. Little is known about gene-expression changes during plant infection by of woody plants such as olive. A complete RNA-seq transcriptomic analysis of olive tree roots was made. Trinity assembler proved to be the best option to assemble the olive and transcriptomes...
March 2017: Plant Genome
https://www.readbyqxmd.com/read/28462469/greater-yogurt-consumption-is-associated-with-increased-bone-mineral-density-and-physical-function-in-older-adults
#18
E Laird, A M Molloy, H McNulty, M Ward, K McCarroll, L Hoey, C F Hughes, C Cunningham, J J Strain, M C Casey
In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults. INTRODUCTION: The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA)...
May 1, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28460994/erectile-dysfunction-treatment-following-radical-cystoprostatectomy-analysis-of-a-nationwide-insurance-claims-database
#19
Meera R Chappidi, Max Kates, Nikolai A Sopko, Gregory A Joice, Jeffrey J Tosoian, Phillip M Pierorazio, Trinity J Bivalacqua
INTRODUCTION: To improve care for patients after radical cystoprostatectomy (RCP), focus on survivorship issues such as sexual function needs to increase. Previous studies have demonstrated the burden of erectile dysfunction (ED) after RCP to be as high as 89%. AIM: To determine the rates of ED treatment use (phosphodiesterase type 5 inhibitors, injectable therapies, urethral suppositories, vacuum erection devices, and penile prosthetics) in patients with bladder cancer before and after RCP to better understand current patterns of care...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28460175/coupled-one-dimensional-plasmons-and-two-dimensional-phonon-polaritons-in-hybrid-silver-nanowire-silicon-carbide-structures
#20
Trinity Joshi, Ji-Hun Kang, Lili Jiang, Sheng Wang, Theron Tarigo, Tairu Lyu, Salman Kahn, Zhiwen Shi, Yuen-Ron Shen, Michael F Crommie, Feng Wang
Surface plasmons (SPs) and phonon polaritons (PhPs) are two distinctive quasiparticles resulting from the strong coupling of photons with electrons and optical phonons, respectively. In this Letter, we investigate the interactions between one-dimensional (1D) plasmons in silver nanowires with two-dimensional (2D) surface phonon polaritons of the silicon carbide (SiC) substrate. Using near-field infrared spectroscopy of the silver nanowire-SiC heterostructure at wavelengths close to the phonon resonance of SiC, we observe that the 1D plasmon dispersion is strongly modified by the 2D phonon polaritons in SiC...
June 14, 2017: Nano Letters
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