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https://www.readbyqxmd.com/read/29350832/the-developmental-trinity-of-mind-cognizance-executive-control-and-reasoning
#1
REVIEW
Andreas Demetriou, Nikolaos Makris, Smaragda Kazi, George Spanoudis, Michael Shayer
This paper summarizes research on how cognizance, that is, awareness of mental processes, interacts with executive control and reasoning from childhood to adolescence. Central positions are that (a) cognizance changes extensively with age; (b) it contributes to the formation of executive control, and (c) mediates between executive control and reasoning. Cognizance recycles with changes in executive and inferential possibilities in four developmental cycles: it registers their present state, yielding insight into their operation, allowing their better management; this catalyzes their transformation into the next level...
January 19, 2018: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#2
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29328062/cyanobacterial-photosynthesis-under-sulfidic-conditions-insights-from-the-isolate-leptolyngbya-sp-strain-hensonii
#3
Trinity L Hamilton, Judith M Klatt, Dirk de Beer, Jennifer L Macalady
We report the isolation of a pinnacle-forming cyanobacterium isolated from a microbial mat covering the sediment surface at Little Salt Spring-a flooded sinkhole in Florida with a perennially microoxic and sulfidic water column. The draft genome of the isolate encodes all of the enzymatic machinery necessary for both oxygenic and anoxygenic photosynthesis, as well as genes for methylating hopanoids at the C-2 position. The physiological response of the isolate to H2S is complex: (i) no induction time is necessary for anoxygenic photosynthesis; (ii) rates of anoxygenic photosynthesis are regulated by both H2S and irradiance; (iii) O2 production is inhibited by H2S concentrations as low as 1 μM and the recovery rate of oxygenic photosynthesis is dependent on irradiance; (iv) under the optimal light conditions for oxygenic photosynthesis, rates of anoxygenic photosynthesis are nearly double those of oxygenic photosynthesis...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29322812/adjustment-to-finger-amputation-and-silicone-finger-prosthesis-use
#4
Zala Kuret, Helena Burger, Gaj Vidmar, Tomaz Maver
PURPOSE: Finger amputations are the most common amputations of upper limbs. They influence hand function, general functioning and quality of life. One of the possibilities for rehabilitation after finger amputation is fitting a silicone finger prosthesis. We wanted to evaluate the adjustment to amputation and prosthesis use in patients after finger amputation. METHODS: We included 42 patients with partial or complete single or multiple finger amputation of one hand who visited the outpatient clinic for prosthetics and orthotics at our institute and received a silicone prosthesis...
January 11, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29314600/the-febs-journal-in-2018-putting-a-bit-of-color-in-your-life-and-your-figures
#5
EDITORIAL
Seamus J Martin
Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He works on all aspects of cell death control and is especially interested in the links between cell death, cell stress and inflammation. He received the GlaxoSmithKline Award of The Biochemical Society (2006) and The RDS-Irish Times Boyle Medal (2015) for his work on the role of caspases in apoptosis and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He is the Editor-in-Chief of The FEBS Journal since 2014...
January 2018: FEBS Journal
https://www.readbyqxmd.com/read/29301100/a-role-for-the-superior-colliculus-in-decision-criteria
#6
Trinity B Crapse, Hakwan Lau, Michele A Basso
Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel "Yes-No" task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report...
January 3, 2018: Neuron
https://www.readbyqxmd.com/read/29299393/de-novo-transcriptome-reconstruction-of-a-thermo-sensitive-male-sterility-mutant-in-rapeseed-brassica-napus-brassicaceae
#7
Xi-Qiong Liu, Cheng-Yu Yu, Jun-Gang Dong, Ai-Xia Xu, Sheng-Wu Hu
Premise of the study: SP2S is a spontaneous thermo-sensitive genic male sterility (TGMS) mutation that facilitates two-line hybrid breeding in Brassica napus (Brassicaceae). De novo assembly of the floral bud transcriptome of SP2S can provide a foundation for deciphering the transcriptional regulation of SP2S in response to temperature change. Methods: mRNAs of the young floral buds of SP2S and its near-isogenic line SP2F grown under cool (16°C)/warm (22°C) conditions were sequenced on an Illumina Solexa platform, producing 239...
December 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/29298680/the-gonadal-transcriptome-of-the-unisexual-amazon-molly-poecilia-formosa-in-comparison-to-its-sexual-ancestors-poecilia-mexicana-and-poecilia-latipinna
#8
Ina Maria Schedina, Detlef Groth, Ingo Schlupp, Ralph Tiedemann
BACKGROUND: The unisexual Amazon molly (Poecilia formosa) originated from a hybridization between two sexual species, the sailfin molly (Poecilia latipinna) and the Atlantic molly (Poecilia mexicana). The Amazon molly reproduces clonally via sperm-dependent parthenogenesis (gynogenesis), in which the sperm of closely related species triggers embryogenesis of the apomictic oocytes, but typically does not contribute genetic material to the next generation. We compare for the first time the gonadal transcriptome of the Amazon molly to those of both ancestral species, P...
January 3, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29298661/de-novo-transcriptome-sequencing-and-analysis-of-male-and-female-swimming-crab-portunus-trituberculatus-reproductive-systems-during-mating-embrace-stage-ii
#9
Zhengfei Wang, Linxia Sun, Weibing Guan, Chunlin Zhou, Boping Tang, Yongxu Cheng, Jintian Huang, Fujun Xuan
BACKGROUND: The swimming crab Portunus trituberculatus is one of the most commonly farmed crustaceans in China. As one of the most widely known and high-value edible crabs, it crab supports large crab fishery and aquaculture in China. Only large and sexually mature crabs can provide the greatest economic benefits, suggesting the considerable effect of reproductive system development on fishery. Studies are rarely conducted on the molecular regulatory mechanism underlying the development of the reproductive system during the mating embrace stage in this species...
January 3, 2018: BMC Genetics
https://www.readbyqxmd.com/read/29288527/development-and-validation-of-a-stability-indicating-hplc-method-for-topiramate-using-mixed-mode-column-and-charged-aerosol-detector
#10
Eduardo Costa Pinto, Mariana da Silva Gonçalves, Lucio Mendes Cabral, Daniel W Armstrong, Valéria Pereira de Sousa
The analysis of topiramate in the presence of its main degradation products is challenging due to the absence of chromophore moieties and their wide range of polarity. Mixed-mode chromatography has been used in such cases because it combines two or more modes of separation. Charged aerosol detector is also an alternative since its detection is independent of optical properties and analyte ionization. This study aimed to develop and validate two new stability-indicating methods by high-performance liquid chromatography for the main degradation products of topiramate using mixed-mode chromatography and a charged aerosol detector...
December 30, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29288005/ex-vivo-culture-of-tumor-cells-from-n-methyl-n-nitrosourea-induced-bladder-cancer-in-rats-development-of-organoids-and-an-immortalized-cell-line
#11
Takahiro Yoshida, Max Kates, Nikolai A Sopko, Xiaopu Liu, Alok K Singh, William R Bishai, Gregory Joice, David J McConkey, Trinity J Bivalacqua
OBJECTIVE: We ex vivo cultured primary tumor cells from N-methyl-N-nitrosourea (MNU)-induced bladder tumors in rats and established an immortalized cell line from them. MATERIALS AND METHODS: Bladder tumors in rats were induced by instillation of MNU into the murine bladder. Primary tumor cells were prepared by the cancer-tissue originated spheroid method. An immortalized cell line was established by co-culture with fibroblasts. The cultured tumor cells were molecularly and functionally characterized by quantitative real-time polymerase chain reaction, Western blot, growth assay, and transwell migration assay...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29280463/cavernous-nerve-injury-by-radiation-therapy-may-potentiate-erectile-dysfunction-in-rats
#12
Javed Mahmood, Caroline Q Connors, Allen A Alexander, Radmila Pavlovic, Santanu Samanta, Sandrine Soman, Hotaka Matsui, Nikolai A Sopko, Trinity J Bivalacqua, Daniel Weinreich, Cheng-Ying Ho, John Eley, Amit Sawant, Isabel L Jackson, Zeljko Vujaskovic
PURPOSE/OBJECTIVES: Radiation-induced erectile-dysfunction (RiED) is one of the most common side effects of radiation therapy (RT) and significantly reduces the quality of life (QoL) of cancer patients. Approximately 50% of prostate cancer patients experience RiED within 3 to 5 years after completion of RT. A series of vascular, muscular, and neurogenic injuries after prostate RT lead to RiED; however, the precise role of RT-induced neurogenic injury in RiED has not been fully established...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29276502/composition-of-micro-eukaryotes-on-the-skin-of-the-cascades-frog-rana-cascadae-and-patterns-of-correlation-between-skin-microbes-and-batrachochytrium-dendrobatidis
#13
Jordan G Kueneman, Sophie Weiss, Valerie J McKenzie
Global amphibian decline linked to fungal pathogens has galvanized research on applied amphibian conservation. Skin-associated bacterial communities of amphibians have been shown to mediate fungal skin infections and the development of probiotic treatments with antifungal bacteria has become an emergent area of research. While exploring the role of protective bacteria has been a primary focus for amphibian conservation, we aim to expand and study the other microbes present in amphibian skin communities including fungi and other micro-eukaryotes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29261279/local-electronic-structure-of-a-single-layer-porphyrin-containing-covalent-organic-framework
#14
Chen Chen, Trinity Joshi, Huifang Li, Anton D Chavez, Zahra Pedramrazi, Pei-Nian Liu, Hong Li, William R Dichtel, Jean-Luc Bredas, Michael F Crommie
We have characterized the local electronic structure of a porphyrin-containing single-layer covalent organic framework (COF) exhibiting a square lattice. The COF monolayer was obtained by the deposition of 2,5-dimethoxybenzene-1,4-dicarboxaldehyde (DMA) and 5,10,15,20-tetrakis (4-aminophenyl) porphyrin (TAPP) onto a Au(111) surface in ultra-high vacuum followed by annealing to facilitate Schiff-base condensations between monomers. Scanning tunneling spectroscopy (STS) experiments conducted on isolated TAPP precursor molecules and the covalently linked COF networks yield similar transport (HOMO-LUMO) gaps of 1...
December 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29247800/de-novo-rna-seq-based-transcriptome-analysis-of-papiliotrema-laurentii-strain-ry1-under-nitrogen-starvation
#15
Soumyadev Sarkar, Somnath Chakravorty, Avishek Mukherjee, Debanjana Bhattacharya, Semantee Bhattacharya, Ratan Gachhui
Nitrogen is a key nutrient for all cell forms. Most organisms respond to nitrogen scarcity by slowing down their growth rate. On the contrary, our previous studies have shown that Papiliotrema laurentii strain RY1 has a robust growth under nitrogen starvation. To understand the global regulation that leads to such an extraordinary response, we undertook a de novo approach for transcriptome analysis of the yeast. Close to 33 million sequence reads of high quality for nitrogen limited and enriched condition were generated using Illumina NextSeq500...
December 13, 2017: Gene
https://www.readbyqxmd.com/read/29244082/quantitation-of-cocaine-and-metabolites-phencyclidine-butalbital-and-phenobarbital-in-meconium-by-liquid-chromatography-tandem-mass-spectrometry
#16
Triniti L Scroggin, Gwendolyn A McMillin
In this study, a quantitative polarity switching liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) method was developed to detect and quantify cocaine and metabolites (cocaethylene, benzoylecgonine and meta-hydroxybenzoylecgonine), phencyclidine (PCP) and barbiturates (phenobarbital and butalbital) in meconium. Accuracy and precision samples at 0.0125% and 75% of the upper limit of quantitation (ULOQ) were analyzed in triplicate over 5 days with accuracy above 84% and average %CV values below 11%...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29233089/de-novo-transcriptome-assembly-from-flower-buds-of-dioecious-gynomonoecious-and-chemically-masculinized-female-coccinia-grandis-reveals-genes-associated-with-sex-expression-and-modification
#17
Ravi Suresh Devani, Sangram Sinha, Jayeeta Banerjee, Rabindra Kumar Sinha, Abdelhafid Bendahmane, Anjan Kumar Banerjee
BACKGROUND: Coccinia grandis (ivy gourd), is a dioecious member of Cucurbitaceae having heteromorphic sex chromosomes. Chromosome constitution of male and female plants of C. grandis is 22A + XY and 22A + XX respectively. Earlier we showed that a unique gynomonoecious form of C. grandis (22A + XX) also exists in nature bearing morphologically hermaphrodite flowers (GyM-H). Additionally, application of silver nitrate (AgNO3) on female plants induces stamen development leading to the formation of morphologically hermaphrodite flowers (Ag-H) despite the absence of Y-chromosome...
December 12, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29214566/improved-diagnosis-and-care-for-rare-diseases-through-implementation-of-precision-public-health-framework
#18
Gareth Baynam, Faye Bowman, Karla Lister, Caroline E Walker, Nicholas Pachter, Jack Goldblatt, Kym M Boycott, William A Gahl, Kenjiro Kosaki, Takeya Adachi, Ken Ishii, Trinity Mahede, Fiona McKenzie, Sharron Townshend, Jennie Slee, Cathy Kiraly-Borri, Anand Vasudevan, Anne Hawkins, Stephanie Broley, Lyn Schofield, Hedwig Verhoef, Tudor Groza, Andreas Zankl, Peter N Robinson, Melissa Haendel, Michael Brudno, John S Mattick, Marcel E Dinger, Tony Roscioli, Mark J Cowley, Annie Olry, Marc Hanauer, Fowzan S Alkuraya, Domenica Taruscio, Manuel Posada de la Paz, Hanns Lochmüller, Kate Bushby, Rachel Thompson, Victoria Hedley, Paul Lasko, Kym Mina, John Beilby, Cynthia Tifft, Mark Davis, Nigel G Laing, Daria Julkowska, Yann Le Cam, Sharon F Terry, Petra Kaufmann, Iiro Eerola, Irene Norstedt, Ana Rath, Makoto Suematsu, Stephen C Groft, Christopher P Austin, Ruxandra Draghia-Akli, Tarun S Weeramanthri, Caron Molster, Hugh J S Dawkins
Public health relies on technologies to produce and analyse data, as well as effectively develop and implement policies and practices. An example is the public health practice of epidemiology, which relies on computational technology to monitor the health status of populations, identify disadvantaged or at risk population groups and thereby inform health policy and priority setting. Critical to achieving health improvements for the underserved population of people living with rare diseases is early diagnosis and best care...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29203268/efficacy-and-safety-of-blue-light-flexible-cystoscopy-with-hexaminolevulinate-hal-in-the-surveillance-of-bladder-cancer-a-phase-iii-comparative-multi-center-study
#19
Siamak Daneshmand, Sanjay Patel, Yair Lotan, Kamal Pohar, Edouard Trabulsi, Michael Woods, Tracy Downs, William Huang, Jeffrey Jones, Michael O'Donnell, Trinity Bivalacqua, Joel DeCastro, Gary Steinberg, Ashish Kamat, Matthew Resnick, Badrinath Konety, Mark Schoenberg, J Stephen Jones, Soroush Bazargani, Michael Cookson, Brian Cross, Costas Dan Lallas, Hoorman Djaladat, Leonard Gomella, Michael Johnson, James McKiernan, Mark Mann, Megan Merrill, Matthew Nielsen, Phillip Pierorazio, Raj Pruthi, Alexander Sankin, Anne Schuckman, Ahmad Shabsigh, Jay B Shah, Angela Smith, Kelley Stratton, Jennifer Taylor, Christopher Weight, Sven Wenske
PURPOSE: To compare blue light flexible cystoscopy (BLFC) with white light flexible cystoscopy (WLFC) in the detection of bladder cancer during surveillance. MATERIALS AND METHODS: Patients at high risk of recurrence received intravesical HAL before WLFC and randomization to BLFC. All suspicious lesions were documented. Patients with suspicious lesions were referred to the operating room (OR) for repeat WLC (white light) and BLC (blue light) cystoscopy. All suspected lesions underwent biopsy or resection and specimens were examined by an independent pathology consensus panel...
December 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29198427/towards-the-identification-of-ancestrally-shared-regenerative-mechanisms-across-the-metazoa-a-transcriptomic-case-study-in-the-demosponge-halisarca-caerulea
#20
Nathan J Kenny, Jasper M de Goeij, Didier M de Bakker, Casey G Whalen, Eugene Berezikov, Ana Riesgo
Regeneration is an essential process for all multicellular organisms, allowing them to recover effectively from internal and external injury. This process has been studied extensively in a medical context in vertebrates, with pathways often investigated mechanistically, both to derive increased understanding and as potential drug targets for therapy. Several species from other parts of the metazoan tree of life, including Hydra, planarians and echinoderms, noted for their regenerative capabilities, have previously been targeted for study...
November 29, 2017: Marine Genomics
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