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https://www.readbyqxmd.com/read/28900367/measurement-of-hba1c-and-hba2-by-capillarys-2-flex-piercing-hba1c-programme-for-simultaneous-management-of-diabetes-and-screening-for-thalassemia
#1
Peifeng Ke, Jiawei Liu, Yan Chao, Xiaobin Wu, Yujuan Xiong, Li Lin, Zemin Wan, Xinzhong Wu, Jianhua Xu, Junhua Zhuang, Xianzhang Huang
INTRODUCTION: Thalassemia could interfere with some assays for haemoglobin A1c (HbA1c) measurement, therefore, it is useful to be able to screen for thalassemia while measuring HbA1c. We used Capillarys 2 Flex Piercing (Capillarys 2FP) HbA1c programme to simultaneously measure HbA1c and screen for thalassemia. MATERIALS AND METHODS: Samples from 498 normal controls and 175 thalassemia patients were analysed by Capillarys 2FP HbA1c programme (Sebia, France). For method comparison, HbA1c was quantified by Premier Hb9210 (Trinity Biotech, Ireland) in 98 thalassaemia patients samples...
October 1, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28899644/transcriptomics-reveals-tissue-organ-specific-differences-in-gene-expression-in-the-starfish-patiria-pectinifera
#2
Chan-Hee Kim, Hye-Jin Go, Hye Young Oh, Yong Hun Jo, Maurice R Elphick, Nam Gyu Park
Starfish (Phylum Echinodermata) are of interest from an evolutionary perspective because as deuterostomian invertebrates they occupy an "intermediate" phylogenetic position with respect to chordates (e.g. vertebrates) and protostomian invertebrates (e.g. Drosophila). Furthermore, starfish are model organisms for research on fertilization, embryonic development, innate immunity and tissue regeneration. However, large-scale molecular data for starfish tissues/organs are limited. To provide a comprehensive genetic resource for the starfish Patiria pectinifera, we report de novo transcriptome assemblies and global gene expression analysis for six P...
September 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28870633/de-novo-assembly-and-annotation-of-the-whole-transcriptome-of-oratosquilla-oratoria
#3
Fangrui Lou, Tianxiang Gao, Shanshan Cai, Zhiqiang Han
As the representative species of Stomatopoda, Oratosquilla oratoria can tolerate the complex benthic environment. In this study, our goal was to develop the transcriptomic resource of O. oratoria that would support adaptation mechanism studies. We generated the whole transcriptome of O. oratoria from combined tissues (eyestalk, muscle, sexual and viscus) using Hiseq technology. A total of 51,305,284 high-quality clean reads were assembled to produce 59,054 non-redundant transcripts with a mean length of 987nt using Trinity and CORSET software...
September 1, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28860173/single-passive-leg-movement-assessment-of-vascular-function-the-contribution-of-nitric-oxide
#4
Ryan M Broxterman, Joel D Trinity, Jayson R Gifford, Oh Sung Kwon, Andrew C Kithas, Jay R Hydren, Ashley D Nelson, David E Morgan, Jacob E Jessop, Amber D Bledsoe, Russell S Richardson
The assessment of passive leg movement (PLM)-induced leg blood flow (LBF) and vascular conductance (LVC) is a novel approach to assess vascular function, which has recently been simplified to only a single PLM (sPLM), thereby increasing the clinical utility of this technique. As the physiological mechanisms mediating the robust increase in LBF and LVC with sPLM are currently unknown, we tested the hypothesis that nitric oxide (NO) is a major contributor to the sPLM-induced LBF and LVC response. In nine healthy men, sPLM was performed with and without the inhibition of nitric oxide synthase (NOS) via intra-arterial infusion of N(G)-monomethyl-L-arginine (L-NMMA)...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28852981/1916-2016-a-centenary-of-publications
#5
G Rahmani, D McNamara
Last year, the centenary of the 1916 Easter rising in Ireland was marked by a commemorative programme organised by the Irish government including both historical and cultural events. The main themes of these events were remembering the past, celebrating Irish achievements and imagining our future. Reviewing the medical literature offers an insight into a century of achievement and change in Irish medicine, captured from the unique perspective of Ireland's oldest medical journal. This manuscript examines papers published during the last 100 years of the Irish Journal of Medical Science, specifically examining the most cited paper from each year...
August 29, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28840684/-transcriptome-characterization-for-scrophularia-ningpoensis-based-on-high-throughput-sequencing-technology-and-related-genes-for-synthesis-of-terpenoid-compounds
#6
Yuan Pan, Da-Xia Chen, Xu-Hong Song, Xue Zhang, Long-Yun Li
To investigate the profile of gene function and search for SSR, a new technology of high-throughput Solexa/Illumina sequencing was used to generate the root transcriptome of Scrophularia ningpoensis, and 65 602 036 raw reads were obtained. Based on the bioinformatics analysis and Trinity, 73 983 unigenes were obtained with an average length of 823 bp. The comparison of sequence homology in database showed that 56 389 unigenes had different degrees of homology. A total of 520 metabolic pathways related genes and 191 relDODO transcription factors were identified by the Swiss-Prot, GO, KEGG and COG...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28834453/intravesical-rad-ifn%C3%AE-syn3-for-patients-with-high-grade-bacillus-calmette-guerin-refractory-or-relapsed-non-muscle-invasive-bladder-cancer-a-phase-ii-randomized-study
#7
Neal D Shore, Stephen A Boorjian, Daniel J Canter, Kenneth Ogan, Lawrence I Karsh, Tracy M Downs, Leonard G Gomella, Ashish M Kamat, Yair Lotan, Robert S Svatek, Trinity J Bivalacqua, Robert L Grubb, Tracey L Krupski, Seth P Lerner, Michael E Woods, Brant A Inman, Matthew I Milowsky, Alan Boyd, F Peter Treasure, Gillian Gregory, David G Sawutz, Seppo Yla-Herttuala, Nigel R Parker, Colin P N Dinney
Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse. We assessed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNα/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory or relapsed NMIBC. Methods In this open-label, multicenter (n = 13), parallel-arm, phase II study ( ClinicalTrials...
August 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28832628/multi-tissue-rna-seq-and-transcriptome-characterisation-of-the-spiny-dogfish-shark-squalus-acanthias-provides-a-molecular-tool-for-biological-research-and-reveals-new-genes-involved-in-osmoregulation
#8
Andres Chana-Munoz, Agnieszka Jendroszek, Malene Sønnichsen, Rune Kristiansen, Jan K Jensen, Peter A Andreasen, Christian Bendixen, Frank Panitz
The spiny dogfish shark (Squalus acanthias) is one of the most commonly used cartilaginous fishes in biological research, especially in the fields of nitrogen metabolism, ion transporters and osmoregulation. Nonetheless, transcriptomic data for this organism is scarce. In the present study, a multi-tissue RNA-seq experiment and de novo transcriptome assembly was performed in four different spiny dogfish tissues (brain, liver, kidney and ovary), providing an annotated sequence resource. The characterization of the transcriptome greatly increases the scarce sequence information for shark species...
2017: PloS One
https://www.readbyqxmd.com/read/28827620/de-novo-transcriptome-assembly-for-the-spiny-mouse-acomys-cahirinus
#9
Jared Mamrot, Roxane Legaie, Stacey J Ellery, Trevor Wilson, Torsten Seemann, David R Powell, David K Gardner, David W Walker, Peter Temple-Smith, Anthony T Papenfuss, Hayley Dickinson
Spiny mice of the genus Acomys display several unique physiological traits, including menstruation and scar-free wound healing; characteristics that are exceedingly rare in mammals, and of considerable interest to the scientific community. These unique attributes, and the potential for spiny mice to accurately model human diseases, are driving increased use of this genus in biomedical research, however little genetic information is accessible for this species. This project aimed to generate a draft transcriptome for the Common spiny mouse (Acomys cahirinus)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814265/a-genome-wide-transcriptome-map-of-pistachio-pistacia-vera-l-provides-novel-insights-into-salinity-related-genes-and-marker-discovery
#10
Maryam Moazzzam Jazi, Seyed Mahdi Seyedi, Esmaeil Ebrahimie, Mansour Ebrahimi, Gianluca De Moro, Christopher Botanga
BACKGROUND: Pistachio (Pistacia vera L.) is one of the most important commercial nut crops worldwide. It is a salt-tolerant and long-lived tree, with the largest cultivation area in Iran. Climate change and subsequent increased soil salt content have adversely affected the pistachio yield in recent years. However, the lack of genomic/global transcriptomic sequences on P. vera impedes comprehensive researches at the molecular level. Hence, whole transcriptome sequencing is required to gain insight into functional genes and pathways in response to salt stress...
August 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28810732/tracking-radionuclide-fractionation-in-the-first-atomic-explosion-using-stable-elements
#11
Chloë E Bonamici, Richard L Hervig, William S Kinman
Compositional analysis of postdetonation fallout is a tool for forensic identification of nuclear devices. However, the relationship between device composition and fallout composition is difficult to interpret because of the complex combination of physical mixing, nuclear reactions, and chemical fractionations that occur in the chaotic nuclear fireball. Using a combination of in situ microanalytical techniques (electron microprobe analysis and secondary ion mass spectrometry), we show that some heavy stable elements (Rb, Sr, Zr, Ba, Cs, Ba, La, Ce, Nd, Sm, Dy, Lu, U, Th) in glassy fallout from the first nuclear test, Trinity, are reliable chemical proxies for radionuclides generated during the explosion...
August 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28808039/preclincial-evaluation-of-intravesical-cisplatin-nanoparticles-for-non-muscle-invasive-bladder-cancer
#12
Max Kates, Abhijit Date, Takahiro Yoshida, Umara Afzal, Pranjali Kanvinde, Taarika Babu, Nikolai A Sopko, Hotaka Matsui, Noah M Hahn, David J McConkey, Alex S Baras, Justin Hanes, Laura Ensign, Trinity J Bivalacqua
PURPOSE: Prior clinical trials evaluating cisplatin for non-muscle invasive bladder cancer (NMIBC) were stopped due to local and systemic toxicity. Currently, there is still a need for improved intravesical therapies, and nanoparticle-based CDDP may be efficacious without the toxicity of free cisplatin observed in the past. EXPERIMENTAL DESIGN: Cisplatin nanoparticles (CDDP NP) were developed using biocompatible poly(L-aspartic acid sodium salt) (PAA), both with and without low and high grafting density of methoxy-polyethylene glycol (PEG)...
August 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28806931/draft-de-novo-transcriptome-assembly-and-proteome-characterization-of-the-electric-lobe-of-tetronarce-californica-a-molecular-tool-for-the-study-of-cholinergic-neurotransmission-in-the-electric-organ
#13
Maria Stavrianakou, Ricardo Perez, Cheng Wu, Matthew S Sachs, Rodolfo Aramayo, Mark Harlow
BACKGROUND: The electric organ of Tetronarce californica (an electric ray formerly known as Torpedo californica) is a classic preparation for biochemical studies of cholinergic neurotransmission. To broaden the usefulness of this preparation, we have performed a transcriptome assembly of the presynaptic component of the electric organ (the electric lobe). We combined our assembled transcriptome with a previous transcriptome of the postsynaptic electric organ, to define a MetaProteome containing pre- and post-synaptic components of the electric organ...
August 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28802692/de-novo-transcriptome-assembly-and-rna-seq-expression-analysis-in-blood-from-beluga-whales-of-bristol-bay-ak
#14
Jeanine S Morey, Kathy A Burek Huntington, Michelle Campbell, Tonya M Clauss, Caroline E Goertz, Roderick C Hobbs, Denise Lunardi, Amanda J Moors, Marion G Neely, Lori H Schwacke, Frances M Van Dolah
Assessing the health of marine mammal sentinel species is crucial to understanding the impacts of environmental perturbations on marine ecosystems and human health. In Arctic regions, beluga whales, Delphinapterus leucas, are upper level predators that may serve as a sentinel species, potentially forecasting impacts on human health. While gene expression profiling from blood transcriptomes has widely been used to assess health status and environmental exposures in human and veterinary medicine, its use in wildlife has been limited due to the lack of available genomes and baseline data...
August 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28802219/development-and-validation-of-a-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-quantify-ly-354-740-in-rat-and-marmoset-plasma
#15
Fleur Gaudette, Adjia Hamadjida, Dominique Bédard, Stephen G Nuara, Francis Beaudry, Philippe Huot
LY-354,740 (eglumegad) is a selective and potent agonist of the metabotropic glutamate group II receptors (mGluR2,3) that has already entered clinical trials as a potential anti-psychotic agent and therefore has well-documented pharmacokinetic (PK), safety and tolerability profiles in human. Whereas its development as an anti-psychotic agent has not been pursued, LY-354,740 may have potential in other neuroscience-related fields, notably anxiety and neuro-protection. The common marmoset is a small primate that has long been used in neuroscience...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28798376/3d-biomimetic-artificial-bone-scaffolds-with-dual-cytokines-spatiotemporal-delivery-for-large-weight-bearing-bone-defect-repair
#16
Xiaogang Bao, Lingjun Zhu, Xiaodong Huang, Dezhi Tang, Dannong He, Jiangang Shi, Guohua Xu
It is a great challenge to prepare "functional artificial bone" for the repair of large segmental defect, especially in weight-bearing bones. In this study, bioactive HA/PCL composite scaffolds that possess anatomical structure as autogenous bone were fabricated by CT-guided fused deposition modeling technique. The scaffolds can provide mechanical support and possess osteoconduction property. Then the VEGF-165/BMP-2 loaded hydrogel was filled into biomimetic artificial bone spatially to introduce osteoinduction and angioinduction ability via sustained release of these cytokines...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790328/desiccation-tolerance-in-bryophytes-the-dehydration-and-rehydration-transcriptomes-in-the-desiccation-tolerant-bryophyte-bryum-argenteum
#17
Bei Gao, Xiaoshuang Li, Daoyuan Zhang, Yuqing Liang, Honglan Yang, Moxian Chen, Yuanming Zhang, Jianhua Zhang, Andrew J Wood
The desiccation tolerant bryophyte Bryum argenteum is an important component of desert biological soil crusts (BSCs) and is emerging as a model system for studying vegetative desiccation tolerance. Here we present and analyze the hydration-dehydration-rehydration transcriptomes in B. argenteum to establish a desiccation-tolerance transcriptomic atlas. B. argenteum gametophores representing five different hydration stages (hydrated (H0), dehydrated for 2 h (D2), 24 h (D24), then rehydrated for 2 h (R2) and 48 h (R48)), were sampled for transcriptome analyses...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780069/serine-protease-related-proteins-in-the-malaria-mosquito-anopheles-gambiae
#18
Xiaolong Cao, Mansi Gulati, Haobo Jiang
Insect serine proteases (SPs) and serine protease homologs (SPHs) participate in digestion, defense, development, and other physiological processes. In mosquitoes, some clip-domain SPs and SPHs (i.e. CLIPs) have been investigated for possible roles in antiparasitic responses. In a recent test aimed at improving quality of gene models in the Anopheles gambiae genome using RNA-seq data, we observed various discrepancies between gene models in AgamP4.5 and corresponding sequences selected from those modeled by Cufflinks, Trinity and Bridger...
September 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28761813/rna-seq-data-from-different-developmental-stages-of-rafflesia-cantleyi-floral-buds
#19
Safoora Amini, Halimah Alias, Mohd Afiq Aizat-Juhari, Mohd-Noor Mat-Isa, Jumaat Haji Adam, Hoe-Han Goh, Kiew-Lian Wan
Rafflesia cantleyi, known as one of the world's largest flowers, is a specialised holoparasite due to dramatic morphological modifications. It possesses highly reduced vegetative structure and only appears as a flower for sexual reproduction. Moreover, it has an unusual life cycle in that its floral bud development takes up to nine months. In order to fully understand the highly modified floral organ structure and long life cycle of R. cantleyi, we used Illumina sequencing technology (HiSeq) for sequence generation followed by de novo assembly of sequence reads...
December 2017: Genomics Data
https://www.readbyqxmd.com/read/28759564/de-novo-assembly-and-annotation-of-the-retinal-transcriptome-for-the-nile-grass-rat-arvicanthis-ansorgei
#20
Melissa M Liu, Michael Farkas, Perrine Spinnhirny, Paul Pevet, Eric Pierce, David Hicks, Donald J Zack
Cone photoreceptors are required for color vision and high acuity vision, and they die in a variety of retinal degenerations, leading to irreversible vision loss and reduced quality of life. To date, there are no approved therapies that promote the health and survival of cones. The development of novel treatments targeting cones has been challenging and impeded, in part, by the limitations inherent in using common rodent model organisms, which are nocturnal and rod-dominant, to study cone biology. The African Nile grass rat (Arvicanthis ansorgei), a diurnal animal whose photoreceptor population is more than 30% cones, offers significant potential as a model organism for the study of cone development, biology, and degeneration...
2017: PloS One
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