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https://www.readbyqxmd.com/read/29228516/refining-prediction-in-treatment-resistant-depression-results-of-machine-learning-analyses-in-the-trd-iii-sample
#1
Alexander Kautzky, Markus Dold, Lucie Bartova, Marie Spies, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Chiara Fabbri, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: The study objective was to generate a prediction model for treatment-resistant depression (TRD) using machine learning featuring a large set of 47 clinical and sociodemographic predictors of treatment outcome. METHOD: 552 Patients diagnosed with major depressive disorder (MDD) according to DSM-IV criteria were enrolled between 2011 and 2016. TRD was defined as failure to reach response to antidepressant treatment, characterized by a Montgomery-Asberg Depression Rating Scale (MADRS) score below 22 after at least 2 antidepressant trials of adequate length and dosage were administered...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228383/oral-fungal-bacterial-biofilm-models-in-vitro-a-review
#2
Marlene Chevalier, Stephane Ranque, Isabelle Prêcheur
Inclusion of fungi as commensals in oral biofilm is an important innovation in oral biology, and this work aimed to review the literature on the available biofilm and related disease in vitro models. Actually, thousands of bacterial and around one hundred of fungal phylotypes can colonize the oral cavity. Taxonomic profiling combined with functional expression analysis has revealed that Candida albicans, Streptococcus mutans and prominent periodontopathogens are not always present or numerically important in candidiasis, caries, or periodontitis lesions...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228380/elderly-versus-nonelderly-patients-with-invasive-aspergillosis-in-the-icu-a-comparison-and-risk-factor-analysis-for-mortality-from-the-aspicu-cohort
#3
D K Matthaiou, G Dimopoulos, F S Taccone, P Bulpa, A M Van den Abeele, B Misset, W Meersseman, H Spapen, T Cardoso, P E Charles, D Vogelaers, S Blot
Data regarding the epidemiology and diagnosis of invasive aspergillosis in the critically ill population are limited, with data regarding elderly patients (≥75 years old) even scarcer. We aimed to further compare the epidemiology, characteristics and outcome of elderly versus nonelderly critically ill patients with invasive aspergillosis (IA) Prospective, international, multicenter observational study (AspICU) including adult intensive care unit (ICU) patients, with a culture and/or direct examination and/or histopathological sample positive for Aspergillus spp...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#4
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29228322/tlr9-stimulation-induces-increase-in-fungicidal-activity-of-human-dendritic-cells-challenged-with-paracoccidioides-brasiliensis
#5
Ivy Rafacho Vieira, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Carolina Mendonça Gorgulho, Ramon Kaneno, Ângela Maria Victoriano Campos Soares
Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which the microorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H2O2 levels...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228271/litpathexplorer-a-confidence-based-visual-text-analytics-tool-for-exploring-literature-enriched-pathway-models
#6
Axel J Soto, Chrysoula Zerva, Riza Batista-Navarro, Sophia Ananiadou
Motivation: Pathway models are valuable resources that help us understand the various mechanisms underpinning complex biological processes. Their curation is typically carried out through manual inspection of published scientific literature to find information relevant to a model, which is a laborious and knowledge-intensive task. Furthermore, models curated manually cannot be easily updated and maintained with new evidence extracted from the literature without automated support. Results: We have developed LitPathExplorer, a visual text analytics tool that integrates advanced text mining, semi-supervised learning and interactive visualization, to facilitate the exploration and analysis of pathway models using statements (i...
December 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29228244/prokaryote-composition-and-predicted-metagenomic-content-of-two-cinachyrella-morphospecies-and-water-from-west-papuan-marine-lakes
#7
D F R Cleary, A R M Polónia, N J de Voogd
Certain sponge species are difficult to identify using traditional morphology and other techniques are often necessary. Here we used 454-pyrosequencing of the 16S rRNA gene to investigate bacterial and archaeal communities of two distinct Cinachyrella morphospecies collected from two Indonesian marine lakes with differing degrees of connection to the surrounding sea. Our main goal was to assess whether these morphospecies hosted distinct bacterial and archaeal communities and to what extent these differed from those found in lake water...
December 5, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29228212/impact-of-body-mass-index-on-outcomes-following-mitral-surgery-does-an-obesity-paradox-exist
#8
Filippo Rapetto, Vito D Bruno, Matthew King, Umberto Benedetto, Massimo Caputo, Gianni D Angelini, Raimondo Ascione, Franco Ciulli, Hunaid A Vohra
OBJECTIVES: This study was conducted to clarify the relationship between body mass index and mitral valve (MV) surgery and to determine whether an 'obesity paradox' exists in the context of surgery for degenerative MV disease. METHODS: In this retrospective single-centre study, we analysed data from 715 patients who underwent mitral surgery for degenerative disease from 2000 to 2015. Patients were classified according to body mass index: underweight (<20 kg/m 2 ), normal weight (20-24...
December 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29228206/airway-and-hard-tissue-dimensions-in-children-treated-with-early-and-later-timed-cervical-headgear-a-randomized-controlled-trial
#9
Johanna Julku, Kirsi Pirilä-Parkkinen, Pertti Pirttiniemi
Background: A Kloehn-type cervical headgear (CH) aims to correct skeletal jaw discrepancy in Class II children. A few studies have reported CH treatment effects on airway dimensions, but none of them have been randomized according to timing. Objectives: To evaluate related craniofacial structures and pharyngeal airway dimensions in children with a Class II occlusion treated with CH and randomized into early and late treatment groups. Trial design: Randomized, parallel-group, prospective controlled trial...
December 8, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29228188/the-impact-of-environmental-factors-on-co2-fixation-by-microalgae
#10
Marcia Morales, León Sánchez, Sergio Revah
Microalgae are among the most productive biological systems for converting sunlight into chemical energy which is used to capture and transform inorganic carbon into biomass. The efficiency of CO2 capture depends on the cultivation system configuration (photobioreactors or open systems) and can vary according to the state of the algal physiology, the chemical composition of the nutrient medium and environmental factors, such as irradiance, temperature and pH. This mini-review is focused on some of the most important environmental factors determining photosynthetic activity, CO2 biofixation, cell growth rates and biomass productivities by microalgae...
December 6, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29228175/sana-netgo-a-combinatorial-approach-to-using-gene-ontology-go-terms-to-score-network-alignments
#11
Wayne B Hayes, Nil Mamano
Motivation: Gene Ontology (GO) terms are frequently used to score alignments between protein-protein interaction (PPI) networks. Methods exist to measure GO similarity between proteins in isolation, but proteins in a network alignment are not isolated: each pairing is dependent on every other via the alignment itself. Existing measures fail to take into account the frequency of GO terms across networks, instead imposing arbitrary rules on when to allow GO terms. Results: Here we develop NetGO, a new measure that naturally weighs infrequent, informative GO terms more heavily than frequent, less informative GO terms, without arbitrary cutoffs, instead downweighting GO terms according to their frequency in the networks being aligned...
December 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29228165/repair-versus-replacement-for-the-surgical-correction-of-tricuspid-regurgitation-a-meta-analysis
#12
Jae Woong Choi, Myoung-Jin Jang, Kyung Hwan Kim, Ho Young Hwang
OBJECTIVES: Tricuspid valve repair (TVr) has both a theoretical advantage in preserving right ventricular function and disadvantages such as a higher risk of repair failure in the long-term compared with tricuspid valve replacement (TVR). This study was conducted to compare the results of TVr with those of TVR to find an optimal treatment option. METHODS: A literature search of 5 databases was performed. The primary outcome was all-cause mortality. Secondary outcomes were tricuspid reoperation and valve-related events...
December 8, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29228149/outcome-after-transvascular-transcatheter-aortic-valve-implantation-in-2016
#13
Luise Gaede, Johannes Blumenstein, Christoph Liebetrau, Oliver Dörr, Won-Keun Kim, Holger Nef, Oliver Husser, Albrecht Elsässer, Christian W Hamm, Helge Möllmann
Aims: We analysed the number of procedures, complications, and in-hospital mortality rates of all patients undergoing transvascular transcatheter aortic valve implantation (TV-TAVI) in comparison to isolated surgical aortic valve replacement (iSAVR) from 2014 to 2016 in Germany. Methods and results: All aortic valve procedures performed in Germany are mandatorily registered in a quality control program. More than 15 000 TV-TAVI procedures were performed in 2016 in Germany...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29228121/low-dose-bisphenol-a-activates-the-erk-signaling-pathway-and-attenuates-steroidogenic-gene-expression-in-human-placental-cells
#14
Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Yu-Chen Cheng, Gwo-Jang Wu, Hsin-Chieh Lan
Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. BPA can be released into the environment and can spread through the food chain. It is well known that BPA exposure leads to lesions, especially in the reproductive system. According to previous studies, BPA reduces newborn numbers in pregnant mice and affects placentation. The placenta is a special endocrine organ during pregnancy. It secretes important hormones, such as progesterone and estrogen, to maintain gestation...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29228100/test-retest-reliability-and-minimal-detectable-change-of-the-d2-test-of-attention-in-patients-with-schizophrenia
#15
Posen Lee, Wen-Shian Lu, Chin-Hsuan Liu, Hung-Yu Lin, Ching-Lin Hsieh
Objective: The d2 Test of Attention (D2) is a commonly used measure of selective attention for patients with schizophrenia. However, its test-retest reliability and minimal detectable change (MDC) are unknown in patients with schizophrenia, limiting its utility in both clinical and research settings. The aim of the present study was to examine the test-retest reliability and MDC of the D2 in patients with schizophrenia. Method: A rater administered the D2 on 108 patients with schizophrenia twice at a 1-month interval...
December 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29228030/logistic-regression-analysis-of-conventional-ultrasonography-strain-elastosonography-and-contrast-enhanced-ultrasound-characteristics-for-the-differentiation-of-benign-and-malignant-thyroid-nodules
#16
Tiantian Pang, Leidan Huang, Yingyuan Deng, Tianfu Wang, Siping Chen, Xuehao Gong, Weixiang Liu
The aim of the study is to screen the significant sonographic features by logistic regression analysis and fit a model to diagnose thyroid nodules. A total of 525 pathological thyroid nodules were retrospectively analyzed. All the nodules underwent conventional ultrasonography (US), strain elastosonography (SE), and contrast -enhanced ultrasound (CEUS). Those nodules' 12 suspicious sonographic features were used to assess thyroid nodules. The significant features of diagnosing thyroid nodules were picked out by logistic regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29228014/a-model-for-warfare-in-stratified-small-scale-societies-the-effect-of-within-group-inequality
#17
Sagar Pandit, Gauri Pradhan, Carel van Schaik
In order to predict the features of non-raiding human warfare in small-scale, socially stratified societies, we study a coalitionary model of war that assumes that individuals participate voluntarily because their decisions serve to maximize fitness. Individual males join the coalition if war results in a net economic and thus fitness benefit. Within the model, viable offensive war ensues if the attacking coalition of males can overpower the defending coalition. We assume that the two groups will eventually fuse after a victory, with ranks arranged according to the fighting abilities of all males and that the new group will adopt the winning group's skew in fitness payoffs...
2017: PloS One
https://www.readbyqxmd.com/read/29227972/serum-hepcidin-and-iron-indices-affect-anemia-status-differently-according-to-the-kidney-function-of-non-dialysis-chronic-kidney-disease-patients-korean-cohort-study-for-outcome-in-patients-with-chronic-kidney-disease-know-ckd
#18
Sung Woo Lee, Yeong Hoon Kim, Wookyung Chung, Sue K Park, Dong Wan Chae, Curie Ahn, Yong-Soo Kim, Su Ah Sung
BACKGROUND/AIMS: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. METHODS: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-2016) and excluded 198 patients with missing data regarding serum hepcidin, hemoglobin, transferrin saturation (TSAT), ferritin, and usage of erythropoiesis-stimulating agents (ESA) or supplemental iron and 363 patients using ESA or supplemental iron...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227948/points-of-attention-in-designing-tools-for-regional-brownfield-prioritization
#19
Elsa Limasset, Lisa Pizzol, Corinne Merly, Annette M Gatchett, Cécile Le Guern, Stanislav Martinát, Petr Klusáček, Stephan Bartke
The regeneration of brownfields has been increasingly recognized as a key instrument in sustainable land management, since free developable land (or so called "greenfields") has become a scare and more expensive resource, especially in densely populated areas. However, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects, thus requiring the development and application of appropriate tools to support decision makers in the selection of promising sites where efficiently allocate the limited financial resources...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227942/the-interaction-between-bacterial-abundance-and-selected-pollutants-concentration-levels-in-an-arctic-catchment-southwest-spitsbergen-svalbard
#20
Klaudia Kosek, Katarzyna Kozak, Krystyna Kozioł, Katarzyna Jankowska, Stanisław Chmiel, Żaneta Polkowska
Persistent organic pollutants (POPs) have been a topic of interest in environmental sciences for >60years. POPs in the Arctic have been investigated since the 1970s, when first atmospheric measurements revealed the presence of these pollutants in the polar regions. Major contaminant transport routes to the Arctic include atmospheric and oceanic transport, as well as inflow from rivers and sea ice. The sources of pollutants, such as industry, power generators, vehicle and ship exhausts, introduce the PAHs, phenols, formaldehyde or metals into the Arctic...
December 8, 2017: Science of the Total Environment
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