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https://www.readbyqxmd.com/read/29684934/-optimal-medical-therapy-and-secondary-prevention-in-patients-after-an-acute-coronary-syndrome
#1
Barbara E Stähli, Ulf Landmesser
Antithrombotic therapy and other secondary preventive measures such as lifestyle changes, lipid lowering and blood pressure control, along with coronary revascularization strategies, can markedly improve clinical outcomes in patients after an acute coronary syndrome. Current guideline-recommended secondary preventive measures in patients with a recent acute coronary syndrome event according to the European Society of Cardiology (ESC) are summarized in this review.
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29684923/percutaneous-endoscopic-interlaminar-unilateral-ventral-dural-approach-for-symptomatic-bilateral-l5-s1-herniated-nucleus-pulposus-technical-note
#2
Sung Ho Choi, Nitin Maruti Adsul, Hyeun Sung Kim, Ki Joon Kim, Jeong Hoon Kim, Sung Kyun Chung, Jeong Hoon Choi, Jee Soo Jang, Il Tae Jang, Seong Hoon Oh
BACKGROUND:  Percutaneous endoscopic lumbar diskectomy is a good treatment modality for lumbar disk herniation. However, when a patient complains of bilateral lower limb radicular pain with severe disk protrusion at the L5-S1 level, the transforaminal approach is often unable to resolve both lesions owing to anatomical limitations. It is also very difficult to resolve both lesions in an ipsilateral direction using the percutaneous interlaminar approach. We report our surgical technique and clinical results using a ventral dural approach of percutaneous endoscopic interlaminar lumbar diskectomy for L5-S1 herniated nucleus pulposus (HNP) in patients with bilateral radiculopathy due to a severe disk protrusion...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29684914/serum-calcium-is-related-to-the-degree-of-artery-stenosis-in-acute-ischemic-stroke
#3
Jiayan Wu, Junchao Xie, Yanxin Zhao, Li Gong, Xueyuan Liu, Wangmi Liu
BACKGROUND/AIMS: Acute ischemic stroke is caused by stenosis of artery supplying to brain. We aimed to detect some metabolites in the serum that would be related to the degree of artery stenosis and to analyze potential mechanisms. METHODS: Patients diagnosed with acute ischemic stroke were divided into two groups according to their degree of artery stenosis (which was determined by computed tomographic angiography): a mild group (stenosis ≤ 30%) and a severe group (stenosis > 30%)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29684912/cementum-regeneration-using-stem-cells-in-the-dog-model-a-systematic-review
#4
REVIEW
Jacqueline Crossman, Maryam Elyasi, Tarek El-Bialy, Carlos Flores Mir
OBJECTIVE: Restoring lost tissues of the periodontium, such as cementum, is essential in reducing the risk of tooth loss due to periodontitis and/or severe root resorption. Stem cell therapy is a regenerative strategy in cementum regeneration. This systematic review aimed to analyze the effect of various stem cells and their transplantation method on cementum regeneration in the dog model. METHODS: Electronic databases were searched, in addition to performing hand searches and a gray literature search...
April 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29684906/the-determination-of-pharmaceutically-active-thiols-using-hydrophilic-interaction-chromatography-followed-postcolumn-derivatization-with-o-phthaldialdehyde-and-fluorescence-detection
#5
Michal Douša
A rapid, precise and specific hydrophilic interaction chromatography (HILIC) combined with postcolumn derivatization using o-phthaldialdehyde and fluorescence detection was developed and validated for the determination of selected pharmaceutically active thiols. The analysis was carried out on a Diol HILIC column using a mobile phase consisting of acetonitrile and solution of 10 mmol/L citric acid adjusted with 1-propylamine to pH 5.5 in ratio 75:25 (v/v) for separation of cysteine and homocysteine and in ratio 85:15 (v/v) for separation of N-acetyl-l-cysteine and captopril...
April 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684893/comparison-of-the-moca-and-bearni-tests-for-detection-of-cognitive-impairment-in-in-patients-with-alcohol-use-disorders
#6
Stéphanie Pelletier, Régis Alarcon, Valérie Ewert, Margot Forest, Bertrand Nalpas, Pascal Perney
INTRODUCTION: Screening of cognitive impairment is a major challenge in alcoholics seeking treatment, since cognitive dysfunction may impair the overall efficacy of rehabilitation programs and consequently increase relapse rate. We compared the performance of two screening tools: the MoCA (Montreal Cognitive Assessment), which is widely used in patients with neurological diseases and already used in patients with alcohol use disorder (AUD), and the BEARNI (Brief Evaluation of Alcohol-Related Neuropsychological Impairments), a recent test specifically developed for the alcoholic population...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684892/effects-of-anxiety-and-mood-disorders-on-craving-and-substance-use-among-patients-with-substance-use-disorder-an-ecological-momentary-assessment-study
#7
Melina Fatseas, Fuschia Serre, Joel Swendsen, Marc Auriacombe
BACKGROUND: Despite recognition of the negative impact of psychiatric comorbidity on addictive disorders, the mechanisms underlying this association remain poorly understood. The present investigation applied mobile technologies to examine the effect of comorbid mood or anxiety disorders on craving intensity and substance use within the natural conditions of daily life. METHODS: A total of 159 participants were recruited from a French outpatient addiction clinic and completed two weeks of computerized ambulatory monitoring of daily life experiences using Ecological Momentary Assessment (EMA)...
April 12, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684879/heavy-metals-in-the-finest-size-fractions-of-road-deposited-sediments
#8
Christof Lanzerstorfer
The concentration of heavy metals in urban road-deposited sediments (RDS) can be used as an indicator for environmental pollution. Thus, their occurrence has been studied in whole road dust samples as well as in size fractions obtained by sieving. Because of the limitations of size separation by sieving little information is available about heavy metal concentrations in the road dust size fractions <20 μm. In this study air classification was applied for separation of dust size fractions smaller than 20 μm from RDS collected at different times during the year...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684841/use-of-visible-and-near-infrared-reflectance-spectra-to-predict-lipid-peroxidation-of-light-lamb-meat-and-discriminate-dam-s-feeding-systems
#9
G Ripoll, S Lobón, M Joy
Measurement of thiobarbituric acid reactive substances (TBARS) is a well-established method for determine lipid oxidation in meat. This assay, however, is time-consuming and generates undesired chemical waste. Dam's milk is the principal source of vitamins and provitamins that delay lipid oxidation of light lamb meat; these compounds are stored in the lamb's muscle tissue. Hence, lamb meat could be used to determine the origin of the dam's diet. The aim of this study is to evaluate Near-infrared reflectance spectroscopy (NIRS) as a tool for determining the lipid peroxidation of light lamb meat and differentiate the meat of light lambs according the diet of their dams during lactation (grazing alfalfa, lucerne, or fed a total mixed ration)...
April 9, 2018: Meat Science
https://www.readbyqxmd.com/read/29684785/photoreceptor-calcium-sensor-proteins-in-detergent-resistant-membrane-rafts-are-regulated-via-binding-to-caveolin-1
#10
Vasiliy I Vladimirov, Evgeni Yu Zernii, Viktoriia E Baksheeva, Hanna Wimberg, Alexey S Kazakov, Natalya K Tikhomirova, Ekaterina L Nemashkalova, Vladimir A Mitkevich, Andrey A Zamyatnin, Valery M Lipkin, Pavel P Philippov, Sergei E Permyakov, Ivan I Senin, Karl-W Koch, Dmitry V Zinchenko
Rod cell membranes contain cholesterol-rich detergent-resistant membrane (DRM) rafts, which accumulate visual cascade proteins as well as proteins involved in regulation of phototransduction such as rhodopsin kinase and guanylate cyclases. Caveolin-1 is the major integral component of DRMs, possessing scaffolding and regulatory activities towards various signaling proteins. In this study, photoreceptor Ca2+ -binding proteins recoverin, NCS1, GCAP1, and GCAP2, belonging to neuronal calcium sensor (NCS) family, were recognized as novel caveolin-1 interacting partners...
April 14, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29684783/accurate-segmenting-of-cervical-tumors-in-pet-imaging-based-on-similarity-between-adjacent-slices
#11
Liyuan Chen, Chenyang Shen, Zhiguo Zhou, Genevieve Maquilan, Kimberly Thomas, Michael R Folkert, Kevin Albuquerque, Jing Wang
Because in PET imaging cervical tumors are close to the bladder with high capacity for the secreted 18 FDG tracer, conventional intensity-based segmentation methods often misclassify the bladder as a tumor. Based on the observation that tumor position and area do not change dramatically from slice to slice, we propose a two-stage scheme that facilitates segmentation. In the first stage, we used a graph-cut based algorithm to obtain initial contouring of the tumor based on local similarity information between voxels; this was achieved through manual contouring of the cervical tumor on one slice...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29684747/the-possible-dna-damage-induced-by-environmental-organic-compounds-the-case-of-nonylphenol
#12
REVIEW
Zahra Noorimotlagh, Seyyed Abbas Mirzaee, Mehdi Ahmadi, Neemat Jaafarzadeh, Fakher Rahim
Human impact on the environment leads to the release of many pollutants that produce artificial compounds, which can have harmful effects on the body's endocrine system; these are known as endocrine disruptors (EDs). Nonylphenol (NP) is a chemical compound with a nonyl group that is attached to a phenol ring. NP-induced H2 AX is a sensitive genotoxic biomarker for detecting possible DNA damage; it also causes male infertility and carcinogenesis. We attempt to comprehensively review all the available evidence about the different ways with descriptive mechanisms for explaining the possible DNA damage that is induced by NP...
April 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29684739/evaluating-meteorological-data-from-weather-stations-and-from-satellites-and-global-models-for-a-multi-site-epidemiological-study
#13
Josh M Colston, Tahmeed Ahmed, Cloupas Mahopo, Gagandeep Kang, Margaret Kosek, Francisco de Sousa Junior, Prakash Sunder Shrestha, Erling Svensen, Ali Turab, Benjamin Zaitchik
BACKGROUND: Longitudinal and time series analyses are needed to characterize the associations between hydrometeorological parameters and health outcomes. Earth Observation (EO) climate data products derived from satellites and global model-based reanalysis have the potential to be used as surrogates in situations and locations where weather-station based observations are inadequate or incomplete. However, these products often lack direct evaluation at specific sites of epidemiological interest...
April 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29684705/dual-tail-arylsulfone-based-benzenesulfonamides-differently-match-the-hydrophobic-and-hydrophilic-halves-of-human-carbonic-anhydrases-active-sites-selective-inhibitors-for-the-tumor-associated-hca-ix-isoform
#14
Hany S Ibrahim, Heba Abdelrasheed Allam, Walaa R Mahmoud, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Eslam S Ibrahim, Hatem A Abdel-Aziz, Claudiu T Supuran
The synthesis and characterization of two new sets of arylsulfonehydrazone benzenesulfonamides (4a-4i with phenyl tail and 4j-4q with tolyl tail) are reported. The compounds were designed according to a dual-tails approach to modulate the interactions of the ligands portions at the outer rim of both hydrophobic and hydrophilic active site halves of human isoforms of carbonic anhydrase (CA, EC 4.2.1.1). The synthesized sulfonamides were evaluated in vitro for their inhibitory activity against the following human (h) isoforms, hCA I, II, IV and IX...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684695/effective-seeding-strategy-using-flat-type-poly-vinyl-alcohol-cryogel-for-anammox-enrichment
#15
Minkyu Choi, Kyungjin Cho, Seockheon Lee, Yun-Chul Chung, Joonhong Park, Hyokwan Bae
In this study, anammox enrichment reactors were operated using flat type poly (vinyl alcohol) cryogel (cryoPVAG) with precultured anammox bacteria (PAB) and activated sludge (AS) from an anoxic tack of the A2O process to evaluate the effect of different seeding sources on anammox enrichment. In addition, cryoPVAGs with different thicknesses (1, 2, and 3 mm) were used to investigate the effects of the thickness on anammox enrichment. The regression analysis with a modified Gompertz model showed that the start-up period of the anammox enrichment using PAB inoculum was approximately 14 days earlier than that of AS inoculum at a nitrogen loading rate of approximately 1 kg-N m-3 day-1 ...
April 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684671/public-health-and-multiple-phase-mortality-decline-evidence-from-industrializing-japan
#16
Kota Ogasawara, Yukitoshi Matsushita
A growing body of literature shows the mitigating effects of water-supply systems on the mortality rates in large cities, yet the heterogeneities in the effects have been understudied. This study fills in the gap in existing knowledge by providing evidence for non-linearity in the effects of clean water using semiparametric fixed effects approach with city-level nationwide longitudinal dataset between 1922 and 1940, which covers 91% of total city population. According to our baseline estimate, the clean water accounts for approximately 27% of the decrease in the crude death rate in this period...
April 7, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29684670/evaluation-of-the-bisap-scoring-system-in-prognostication-of-acute-pancreatitis-a-prospective-observational-study
#17
Sumitra Hagjer, Nitesh Kumar
INTRODUCTION: Severe acute pancreatitis has a high mortality and its early identification is important for management and risk stratification. The bedside index for severity in acute pancreatitis (BISAP) is a simple scoring system done at admission which predicts the severity of pancreatitis. Procalcitonin is an inflammatory marker which is raised very early and helps in early prediction of the severity of disease. This study aims to evaluate the BISAP score and Procalcitonin in prognostication of acute pancreatitis...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684627/bioadhesives-for-internal-medical-applications-a-review
#18
REVIEW
Wenzhen Zhu, Yon Jin Chuah, Dong-An Wang
Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have gained increasing popularity in different areas of clinical operations during the last three decades. Bioadhesives can be categorized into internal and external ones according to their application conditions. External bioadhesives are generally applied in topical medications such as wound closure and epidermal grafting. Internal bioadhesives are mainly used in intracorporal conditions with direct contact to internal environment including tissues, organs and body fluids, such as chronic organ leak repair and bleeding complication reduction...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684617/association-of-diabetes-mellitus-with-prostate-cancer-grade-and-prostate-specific-antigen-in-chinese-biopsy-population
#19
Ming Chen, Yili Luo, Shaoling Yang, Lu Xu, Nan Li, Hong Li, Shen Qu
AIMS: To investigate the association of diabetes mellitus with prostate cancer (PCa) grade and prostate-specific antigen (PSA) in Chinese biopsy population. METHODS: We retrospectively evaluated data from 2032 patients who underwent prostate biopsies from 2010-2016 at our hospital. All diabetes cases were divided into sub-groups according to HbA1c (< 6.5%, 6.5%-7.49% and ≥ 7.5%) and diabetes duration (0-5 years, 6-10 years and > 10 years). RESULTS: Among 2032 men, 467 (23...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684577/predictors-of-switching-from-non-steroidal-anti-inflammatory-drugs-to-corticosteroids-in-patients-with-acute-pericarditis-and-impact-on-clinical-outcome
#20
George Lazaros, Alexios S Antonopoulos, Charalambos Vlachopoulos, Evangelos Oikonomou, Apostolos Karavidas, Christina Chrysohoou, Emilia Lazarou, Dimitrios Vassilopoulos, Massimo Imazio, Dimitris Tousoulis
BACKGROUND: Aspirin and non-steroidal anti-inflammatory drugs (A/NSAIDs) are the mainstay treatments for of acute pericarditis. We sought to identify factors predicting A/NSAIDs failure and switch to corticosteroid treatment (STCT) as well as the impact of STCT on pericarditis recurrence. METHODS: We enrolled 148 patients with acute pericarditis receiving A/NSAID (n=110) or corticosteroids (n=38) as first line treatment according to clinical indications. In case of poor response to A/NSAIDs (n=37), STCT was performed and factors contributing to such failure were explored...
April 20, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
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