Syringoid sweat gland carcinoma

Syringoid eccrine carcinomas (SECs) are rare adnexal neoplasms that may display aggressive local recurrence and occasional metastases. This report describes three cases of SEC treated by Mohs micrographic surgery.

We report on a 59-year-old woman suffering from desmoplastic syringoid eccrine carcinoma with basal cell epithelioma at her right temple. 40 years ago, lupus vulgaris had been X-rayed in this area.

A case of syringoid eccrine carcinoma (SEC) is reported. The tumor was mainly formed by clear cells laden with glycogen. This feature, rarely found in syringoma, had not previously been reported in SEC. The authors assume that SEC is an infiltrating and locally destructive but not metastasizing neoplasm. They propose that SEC is a clinicopathologic entity with a histopathologic spectrum from the more differentiated syringomatoid ones to so-called primary cutaneous adenoid cystic carcinoma. A possible nexus between the more syringomatoid cases and the sclerosing sweat duct (syringomatous) carcinoma is also discussed...

Eccrine carcinomas are locally aggressive and have an infiltrative growth pattern. They have a variable clinical appearance and a diversity of histologic findings that often make the diagnosis difficult. The histologic findings, together with immunoperoxidase and enzyme histochemical studies, usually allow differentiation between eccrine carcinomas, other cutaneous neoplasms, and visceral adenocarcinomas with skin metastases. Provided there is no evidence of distant metastases, surgical excision is the treatment of choice...