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Syringoid sweat gland carcinoma

Prachi G Agrawal, Sunanda A Mahajan, Uday S Khopkar, Vidya D Kharkar
Epidermodysplasia verruciformis (EV) is a rare, life-long heritable disease caused due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions and pityriasis versicolor-like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. Malignant transformation into syringoid eccrine carcinoma (SEC) has been reported only once so far. SEC is an extremely invasive, rare, locally destructive, slowly growing adnexal tumor. We hereby report the association of EV with SEC in a 29-year-old male...
January 2013: Indian Journal of Dermatology, Venereology and Leprology
M Sidiropoulos, S Sade, A Al-Habeeb, D Ghazarian
BACKGROUND: Syringoid eccrine carcinoma (SEC) is a rare malignant adnexal tumour with variable presentations. AIM: To examine the clinicopathological and immunohistochemical features of SEC. METHODS: Four cases were reviewed by three dermatopathologists and the immunohistochemical profile was examined using antibodies against CK5/6, CK7, CK14, CK20, LMWK, HMWK, EMA, mCEA, p63, ER, PR, AR, S-100 and Ber-EP4. RESULTS: The cases occurred in two men and two women, ranging in age from 61 to 87 years (mean 68...
September 2011: Journal of Clinical Pathology
Chuieng-Yi Lu, Shih-Ming Jung, Yu-Te Lin
We present a case of sclerosing syringoid carcinoma of the finger, a type of eccrine sweat duct malignancy that is rare and mimics the appearance of a benign lesion, but is locally aggressive and has a tendency to recur. It has seldom been reported in the literature. It has a predilection for the head and neck region but is rare in the extremities. We believe this is the second reported case of sclerosing syringoid carcinoma in the finger, after the diagnosis was determined from a histological and immunohistochemical study...
January 2011: Chang Gung Medical Journal
Mohamed Khalifa Ahmed, Takashi Ishino, Katsuhiro Hirakawa, Koji Arihiro
First described in 1969, syringoid eccrine carcinoma (SEC) is a rare cutaneous tumor with some controversy regarding its correct definition. It consists of solid nests and small cords in a dense fibrocollagenous stroma. As it is rare, its clinical appearance is not well characterized and its biological behaviour is not defined. It usually affects skin of the scalp, extremities and more rarely, other sites. It behaves as locally aggressive tumor but metastases are rare. Although there have been some previous reports describing clinical presentation and management of SEC in the skin, there has been no previous reports describing clinical findings and management of this tumor in the external auditory canal...
August 2010: Auris, Nasus, Larynx
Jorge O Güerrissi, Juan Pablo Quiroga
Adnexal carcinomas of the skin are rare and they derive from structures such as sweat glands, sebaceous glands, and hair follicles. Adnexal tumors represent 1-2% of skin cancers. Between 1998 and 2004, eight patients with malignant adnexal tumors of the head and neck were treated in the Plastic Surgery Service in Argerich Hospital in Buenos Aires, Argentina. Four (50%) of them had malignant cylindromas, two (25%) had sebaceous carcinoma, and the other two (25%) syringoid eccrine carcinoma. Tumor resection and local flaps were made in all cases...
July 2008: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Umberto Goglia, Carlo Toncini, Massimo Giusti, Christian Gastaldi, Carlo Ambruosi, Simona Sola, Jean-Louis Ravetti, Giorgio Carmignani, Francesco Minuto, Diego Ferone
No abstract text is available yet for this article.
January 2008: Journal of Andrology
Aya Nishizawa, Yukihiro Nakanishi, Yuko Sasajima, Naoya Yamazaki, Akifumi Yamamoto
No abstract text is available yet for this article.
October 2006: International Journal of Dermatology
Y Minami, K Uede, K Sagawa, A Kimura, T Tsuji, F Furukawa
BACKGROUND: Recently, the novel antimicrobial peptide named dermcidin (DCD) was reported in human eccrine sweat glands. OBJECTIVES: We investigated the expression of DCD in a variety of cutaneous tumours in order to assess the usefulness of the monoclonal antibody (G-81), which recognizes a fragment of DCD. PATIENTS/METHODS: We studied the immunoreactivity of the G-81 antibody on 197 cutaneous tumours. RESULTS: A total of 13 of 26 cutaneous mixed tumours showed substantial immunoreactivity...
July 2004: British Journal of Dermatology
Takamitsu Ohnishi, Sakae Kaneko, Motoko Egi, Hajime Takizawa, Shinichi Watanabe
Syringoid eccrine carcinoma is an extremely rare cutaneous malignant tumor, thought to be derived from eccrine sweat apparatus. We report a case of syringoid eccrine carcinoma occurring on the scalp of a 66-year-old woman and analyzed its cytokeratin expression immunohistochemically to clarify its histogenesis. The tumor consisted mainly of numerous small cords and nests extending from the reticular dermis to the subcutaneous tissue, which formed luminal or tubular structures mimicking the nests of syringoma...
October 2002: American Journal of Dermatopathology
T Gregurek-Novak, J Talan-Hranilović, N Troskot, M Vucić, B Kruslin
A rare case of a syringoid eccrine carcinoma in a 52-year-old male patient is described. During the first hospitalization, syringoma was diagnosed, both clinically and histologically, keeping in mind the possibility of its malignant alteration. Difficulties in making a diagnosis with histological and immunohistochemical examinations are reported. The possibility of differential diagnosis of primary breast carcinoma and methods of its exclusion are also described. Treatment of the patient was surgical with good results...
March 2001: Journal of the European Academy of Dermatology and Venereology: JEADV
D Ramos, C Monteagudo, C Carda, E Montesinos, J Ferrer, A Peydro-Olaya
Syringoid carcinoma (syringoid "eccrine" carcinoma or eccrine epithelioma) is a rare cutaneous tumor with some controversy regarding its correct definition. It may also be difficult to differentiate from its benign counterpart (syringoma), other adnexal carcinomas, and cutaneous metastasis from adenocarcinomas. We present a case of a syringoid carcinoma of the clear cell variant complemented with an immunohistochemical and ultrastructural study, the latter revealing cytoplasmic accumulation of glycogen and presence of intercellular and intracellular lumina in clear tumor cells, as well as diverse hallmarks of malignancy (i...
February 2000: American Journal of Dermatopathology
M Malmusi, G Collina
We report a case of syringoid eccrine carcinoma, a rare syringomatous tumor of the skin, occurring in a 70-year-old woman. Histological and immunohistochemical criteria are given to differentiate this neoplasm from other primary carcinomas of the skin as well as from skin metastases of internal malignancies.
October 1997: American Journal of Dermatopathology
P Beaulieu, C Blanchet-Bardon, F Breitburd, O Verola, M Favre, L Dubertret
No abstract text is available yet for this article.
1993: Annales de Dermatologie et de Vénéréologie
G Serrano, A Aliaga, J Bonillo, C Pelufo, D Otero
A case of eccrine epithelioma is presented. A 62-year-old woman was seen for with a lesion on the left forearm present for 36 years, and complicated by multiple recurrences. Histopathologically, it was composed of numerous small nests of basaloid cells, cystic and syringoid epithelial structures within the reticular dermis and invading the contiguous fat and muscle tissues. Tubular structures and cystic spaces contained PAS-positive, diastate-resistant, and alcian blue-positive material. Although the tumor was very aggressive locally, no metastasis had occurred throughout its long course...
December 1984: Journal of Cutaneous Pathology
J M Burket, A S Zelickson
A tumor is reported that had remarkable pathologic changes showing with light microscopy a pattern in some portions consistent with tubular apocrine adenoma, while other areas were suggestive of syringoid eccrine carcinoma. Perineural invasion, commonly seen in syringoid eccrine carcinoma and never before reported in tubular apocrine adenoma, was found. Electron microscopy revealed the true apocrine nature of the tumor even though the tissue had been stored for 2 months in buffered formalin prior to processing...
October 1984: Journal of the American Academy of Dermatology
A H Mehregan, K Hashimoto, H Rahbari
A clinicopathologic study was made of 35 patients with primary eccrine adenocarcinoma diagnosed in the past 20 years from among 450,000 consecutive skin biopsy specimens. Histologically the following four distinct variants were identified: eccrine porocarcinoma (18 cases), syringoid eccrine carcinoma (12 cases), mucinous eccrine carcinoma (three cases), and clear cell eccrine carcinoma (two cases). Overall, eccrine adenocarcinomas are destructive lesions with a tendency to local recurrence. The syringoid histologic variant appears to be well differentiated and may have a benign clinical course; the lesion remained localized to the skin in our 12 cases...
February 1983: Archives of Dermatology
P J Weber, J C Gretzula, L D Garland, O Hevia, H Menn
Syringoid eccrine carcinomas (SECs) are rare adnexal neoplasms that may display aggressive local recurrence and occasional metastases. This report describes three cases of SEC treated by Mohs micrographic surgery.
January 1987: Journal of Dermatologic Surgery and Oncology
H Gartmann, A Kuhn
We report on a 59-year-old woman suffering from desmoplastic syringoid eccrine carcinoma with basal cell epithelioma at her right temple. 40 years ago, lupus vulgaris had been X-rayed in this area.
September 1, 1986: Zeitschrift Für Hautkrankheiten
E Sánchez Yus, L Requena Caballero, I Garcia Salazar, S Coca Menchero
A case of syringoid eccrine carcinoma (SEC) is reported. The tumor was mainly formed by clear cells laden with glycogen. This feature, rarely found in syringoma, had not previously been reported in SEC. The authors assume that SEC is an infiltrating and locally destructive but not metastasizing neoplasm. They propose that SEC is a clinicopathologic entity with a histopathologic spectrum from the more differentiated syringomatoid ones to so-called primary cutaneous adenoid cystic carcinoma. A possible nexus between the more syringomatoid cases and the sclerosing sweat duct (syringomatous) carcinoma is also discussed...
June 1987: American Journal of Dermatopathology
R L Moy, J E Rivkin, H Lee, W S Brooks, J A Zitelli
Eccrine carcinomas are locally aggressive and have an infiltrative growth pattern. They have a variable clinical appearance and a diversity of histologic findings that often make the diagnosis difficult. The histologic findings, together with immunoperoxidase and enzyme histochemical studies, usually allow differentiation between eccrine carcinomas, other cutaneous neoplasms, and visceral adenocarcinomas with skin metastases. Provided there is no evidence of distant metastases, surgical excision is the treatment of choice...
May 1991: Journal of the American Academy of Dermatology
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