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Morpheaform basal cell carcinoma

André Bandiera de Oliveira Santos, Natália Martins Magacho de Andrade, Lenine Garcia Brandão, Claudio Roberto Cernea
INTRODUCTION: Perineural invasion is a unique route for tumor dissemination. In basal cell carcinomas, the incidence is low, but increases in advanced cases. Its importance is recognized but not fully understood. OBJECTIVE: To compare head and neck basal cell carcinomas with and without perineural invasion. METHODS: A retrospective medical chart review of multidisciplinary surgeries for basal cell carcinomas that required a head and neck surgery specialist in a tertiary referral center was performed...
April 19, 2016: Brazilian Journal of Otorhinolaryngology
Kartikay Saxena, Vidya Manohar, Vikas Bhakhar, Sumit Bahl
Basal cell carcinoma (BCC) is a common, locally invasive epithelial malignancy of skin and its appendages. Every year, close to 10 million people get diagnosed with BCC worldwide. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and miscellaneous variants (clear-cell, signet ring cell, granular, giant cell, adamantanoid, schwannoid) are even rarer, accounting for <10% of all BCC's. Adenoid BCC (ADBCC) is a very rare histopathological variant with reported incidence of only approximately 1...
2016: BMJ Case Reports
Ellen East, Douglas R Fullen, David Arps, Rajiv M Patel, Nallasivam Palanisamy, Shannon Carskadon, Paul W Harms
BACKGROUND: Morpheaform basal cell carcinoma (BCC) is a variant of BCC characterized by narrow strands and nests of basaloid cells with dense sclerotic stroma. The histologic extent often exceeds the clinical impression, leading to high recurrence rates after standard excision. The authors encountered a case with single-cell invasion distant from the main tumor. To date a systematic review of single-cell infiltration in morpheaform BCC has yet to be performed. DESIGN: Ten morpheaform BCCs, 10 nonmorpheaform aggressive BCCs, 5 desmoplastic trichoepitheliomas, and 2 microcystic adnexal carcinomas were identified by database search and confirmed on hematoxylin and eosin...
October 2016: American Journal of Dermatopathology
Z Apalla, A Lallas, E Sotiriou, E Lazaridou, E Vakirlis, M Trakatelli, A Kyrgidis, D Ioannides
BACKGROUND: Ultraviolet radiation plays an important role in the pathogenesis of non-melanoma skin cancer. Outdoor workers, including farmers, experience higher exposure levels compared to the general population. Available literature data suggest that occupational ultraviolet exposure represents an independent risk factor for squamous cell carcinoma; whereas for basal cell carcinoma (BCC) this association still remains unclarified. OBJECTIVES: To analyse the epidemiological, clinical and histological data of patients diagnosed with BCC, and correlate them with outdoor occupation in farmers...
April 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Qiongyu Wang, Deepak Ghimire, Juan Wang, Suju Luo, Zhengxiao Li, Hao Wang, Songmei Geng, Shengxiang Xiao, Yan Zheng
Desmoplastic trichoepithelioma (DTE) is a rare benign adnexal tumor with the characteristic features of asymptomatic, solitary, annular, indurated and centrally depressed papules or plaques, most commonly occurring in younger individuals on the face. Microscopically and clinically, DTE may be difficult to distinguish from other cutaneous adnexal neoplasms, particularly syringoma, cutaneous metastatic breast cancer, morpheaform basal cell carcinoma and microcystic adnexal carcinoma. The present study reports three cases of DTE...
October 2015: Oncology Letters
I Hoorens, A Batteauw, G Van Maele, K Lapiere, B Boone, K Ongenae
BACKGROUND: The incidence of basal cell carcinoma (BCC) is rising and BCC treatment has an important impact on healthcare budget. Mohs micrographic surgery (MMS) has the highest 5-year cure rate but is an expensive technique. OBJECTIVES: To study the indication criteria for MMS, using a series of 1062 patients treated for facial BCCs between 1998 and 2011. METHODS: The accuracy of the indication criteria was evaluated by comparing the characteristics of BCC requiring one vs...
April 2016: British Journal of Dermatology
Andrei Theodor Bălăşoiu, Maria Rodica Mănescu, Maria Bălăşoiu, Ioan Avrămoiu, Ionica Pirici, Marian Burcea, Laurenţiu Mogoantă, Carmen Luminiţa Mocanu
The eyelids represent a frequent site for numerous malignant tumors, which generally present subtle symptoms or can imitate benignant tumors. Our study was carried on 80 patients, 48 males and 32 females aged between 48 and 92 years. The patients were hospitalized in the Ophthalmology Clinic of the Emergency County Hospital of Craiova, Romania. The study was conducted over five years, between 2010 and 2014. Our study included 80 basal cell carcinomas of the eyelids, of which 48 (60%) were nodular basal cell carcinomas, 15 (18...
2015: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Mara Therese P Evangelista, Jeffrey P North
BACKGROUND: Desmoplastic trichoepithelioma (DTE), morpheaform basal cell carcinoma (BCC) and microcystic adnexal carcinoma (MAC) are sclerosing adnexal neoplasms with overlapping histopathologic features. We compared cytokeratin 15, (CK15), T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20) and androgen receptor (AR) in differentiating these tumors and assessed their expression in BCC subtypes. METHODS: Fifteen DTE, 15 infundibulocystic BCC, 18 micronodular BCC, 18 morpheaform BCC and 6 MAC were assessed for CK15, TDAG51, CK20 and AR expression...
November 2015: Journal of Cutaneous Pathology
Alexandra Boehringer, Patrick Adam, Saskia Schnabl, Hans-Martin Häfner, Helmut Breuninger
Basal-cell carcinomas may show irregular, asymmetric subclinical growth. This study analyzed the efficacy of 'breadloaf' microscopy (serial sectioning) and three-dimensional (3D) microscopy in detecting positive tumor margins. Two hundred eighty-three (283) tumors (51.2%) were put into the breadloaf microscopy group; 270 tumors (48.8%) into the 3D microscopy group. The position of any detected tumor outgrowths was identified in clock face fashion. The time required for cutting and embedding the specimens and the examination of the microscopic slides was measured...
August 2015: Journal of Cutaneous Pathology
Lukas G Rasulić, Milan D Jovanović
BACKGROUND/AIM: Basal cell carcinoma (BCC) is one of the most common malignant skin tumors on the head in 90% of cases and is characterized by a high local infiltrating potential and destructive growth. The aim of this study was to show the characteristics of a correlation between pathohistological types of basal cell carcinoma and the size of this lesion, aggressiveness and infiltration of basal cell carcinoma, and its effect on the course of the therapy. METHODS: We analyzed 27 patients operated on for BCC that affected the scalp and the bone...
November 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Mirjana Popadić
BACKGROUND: Many different phenotypic presentations of basal cell carcinoma (BCC) are possible. OBJECTIVE: This study aims to highlight the similarities and differences in dermoscopic features between different morphologic types of BCC. METHODS: A prospective observational study was performed using contact polarized dermoscopy to evaluate the presence of various dermoscopic features. Images were evaluated for a range of dermoscopic colors, structures, and vessels...
July 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Răzvan Mercut, Marius Eugen Ciurea, Claudiu Mărgăritescu, Sanda Mihaela Popescu, Monica Mihaela Crăitoiu, Ovidiu Simion Cotoi, Doina Carina Voinescu
Although, generally BCC growths slowly and is minimally invasive, tumors developed in the head and neck region behave more aggressively with deep tissue invasion, recurrence and even local or distant metastases, causing significant morbidity or mortality. Recently, numerous studies have been conducted in order to identify new prognostic markers of BCC aggressiveness, but the results are not consistent. Thus, we were interested here in the immunohistochemical investigation of p53, D2-40 and α-SMA expression in the aggressive forms (eight infiltrative-morpheaform, six micronodular and six metatypical cases) versus superficial facial BCCs (five cases)...
2014: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Mirjana Popadić
BACKGROUND: Many different phenotypic presentations of basal cell carcinoma (BCC) are possible. OBJECTIVE: This study aims to highlight the similarities and differences in dermoscopic features between different morphologic types of BCC. METHODS: A prospective observational study was performed using contact polarized dermoscopy to evaluate the presence of various dermoscopic features. Images were evaluated for a range of dermoscopic colors, structures, and vessels...
June 12, 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Zi-xue Chen, Mei-shan Zhou, Ping Tu, Xue-ying Li, Shu-xia Yang, Yuan-shen Huang, Hang Li
OBJECTIVE: To investigate the clinical and histopathological characteristics of basal cell carcinoma (BCC) in Chinese patients. METHODS: Clinical and pathological data of BCC confirmed by histology from 2010 to 2012 in Peking University First Hospital were retrospectively analyzed. RESULTS: Among 418 patients enrolled, the male/female ratio was 0.77:1. The average age was (65.39±13.51) years. Among the patients younger than 60 years who occupied 29% of all the cases, the male/female ratio was 1...
April 18, 2014: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Myrto Trakatelli, Colin Morton, Eduardo Nagore, Claas Ulrich, Veronique Del Marmol, Ketty Peris, Nicole Basset-Seguin
BACKGROUND: European guidelines for the management of basal cell carcinoma (BCC) prepared by the former BCC subcommittee of the Guidelines Committee of the European Dermatology Forum (EDF) were published in 2006. OBJECTIVES: To present updated guidelines that include consensual expert definitions on various BCC types, prognosis and risk factors for BCC as well as review recommendations for diagnosis and treatment reflecting current published evidence. METHODS: These guidelines (S1 type) were prepared by the new BCC subgroup of the European Dermatology Forum (EDF)'s Guidelines Committee through extensive literature review (up to 2012) and expert experience; they were extensively discussed within the EDF subcommittee and approved by peer reviewers of the EDF...
May 2014: European Journal of Dermatology: EJD
Patrick M Mulvaney, H William Higgins, Raymond G Dufresne, Antonio P Cruz, Kachiu C Lee
BACKGROUND: On pathology review, basal cell carcinomas (BCCs) on the ear more commonly present as aggressive subtypes. It is unclear if this histologic observation translates into more clinically aggressive tumors. OBJECTIVE: We sought to determine the clinical aggressiveness of ear BCCs compared with BCCs elsewhere on the head and neck. METHODS: We conducted a retrospective chart review of all BCCs treated at an academic center from 2005 through 2012...
May 2014: Journal of the American Academy of Dermatology
Guy J Ben Simon, Semion Lukovetsky, Fabio Lavinsky, Nahum Rosen, Mordechai Rosner
Background. Basal cell carcinoma (BCC) is the most common malignancy of the eyelids. Medial canthal BCCs tends to recur more often. Purpose. To evaluate the clinical and histological features of primary and recurrent periocular BCC, in order to identify any existing associations. Methods. Data from 87 patients (71 primary and 16 recurrent) were analyzed in this study. All patients underwent tumor excision with frozen section margin control at the Goldschleger Eye Institute between 1/1995 to 12/1997. Statistical analysis was performed to identify possible associations between histological and clinical characteristics of primary and recurrent BCC...
2012: ISRN Ophthalmology
Lucija Vanjaka-Rogošić, Neira Puizina-Ivić, Lina Mirić, Veljko Rogošić, Ivana Kuzmić-Prusac, Mirna Saraga Babić, Dubravka Vuković, Snježana Mardešić
The immunohistochemical staining of matrix metalloproteinases (MMPs) and E-cadherin in tumor epithelial and stromal cells was analyzed in a group of solid, superficial spreading and cystic tumors and in a group of morpheaform and recurrent basal cell carcinomas (BCC) in order to determine whether any of these factors possibly contribute to tumor therapy resistance. Tumor tissues of 64 patients were obtained by complete excisional or curettage biopsy of BCC and these were immunohistochemically stained for MMP-1, MMP-2, MMP-9, MMP-13 and E-cadherin...
June 2014: Acta Histochemica
M E Ciurea, Daniela Cernea, C C Georgescu, O S Cotoi, V Pătraşcu, H Pârvănescu, D Popa, V Pârvănescu, Raluca Niculina Ciurea, R Mercuţ
Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans, accounting for almost 80% of all non-melanoma skin cancers worldwide. The nodular and infiltrative-morpheaform are the most common BCC types in the head and neck region and together with the micronodular subtypes are the most aggressive tumors, because of their tendency to infiltrate the deep subcutis, muscles and even bones. To explain the local aggressive behavior and their metastatic potential, many studies have been performed to identify the molecular determinants implicated in BCC tumor progression...
2013: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Klaus Sellheyer, Paula Nelson, Heinz Kutzner, Rajiv M Patel
BACKGROUND: Microcystic adnexal carcinoma (MAC), desmoplastic trichoepithelioma (DTE) and morpheaform basal cell carcinoma (BCC) frequently impose a considerable differential diagnostic challenge and immunohistochemistry is often used as a differentiating diagnostic adjunct. METHODS: Using standard immunohistochemical techniques, we examined 21 examples of DTE, 17 examples of morpheaform BCC and 10 examples of MAC for the expression of BerEP4, a marker of epithelial cells, and of three stem cell markers, pleckstrin homology-like domain, family A, member 1 (PHLDA1) [T cell death-associated gene 51 (TDAG51)], cytokeratin 15 (CK15) and cytokeratin (CK19)...
April 2013: Journal of Cutaneous Pathology
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