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https://www.readbyqxmd.com/read/29786898/adults-with-comorbid-posttraumatic-stress-disorder-alcohol-use-disorder-and-opioid-use-disorder-the-effectiveness-of-modified-prolonged-exposure
#1
Kelly R Peck, Julie A Schumacher, Paul R Stasiewicz, Scott F Coffey
Opioid use disorders (OUDs) are a growing problem in the United States. When OUDs co-occur with problematic drinking and posttraumatic stress disorder (PTSD), negative drug-related mental and physical health outcomes may be exacerbated. Thus, it is important to establish whether PTSD treatments with established efficacy for dually diagnosed individuals also demonstrate efficacy in individuals who engage in problematic drinking and concurrent opioid misuse. Adults who met DSM-IV-TR criteria for PTSD and alcohol dependence were recruited from a substance use treatment facility and were randomly assigned to receive either modified prolonged exposure (mPE) therapy for PTSD or a non-trauma-focused comparison treatment...
May 22, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29786878/dietary-omega-3-fatty-acids-differentially-impact-acute-ethanol-responsive-behaviors-and-ethanol-consumption-in-dba-2j-versus-c57bl-6j-mice
#2
Jennifer T Wolstenholme, M Scott Bowers, Alexander B Pais, A Christian Pais, Ryan S Poland, Justin L Poklis, Andrew G Davies, Jill C Bettinger
BACKGROUND: Complex interactions between environmental and genetic factors influence the risk for developing alcohol use disorder (AUD) in humans. To date, studies of the impact of environment on AUD risk have primarily focused on psychological characteristics or on the effects of developmental exposure to ethanol. We recently observed that modifying levels of the long-chain ω-3 (LC ω-3) fatty acid, eicosapentaenoic acid (EPA), alters acute physiological responses to ethanol in C. elegans...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786874/meta-analysis-of-the-association-of-alcohol-related-social-media-use-with-alcohol-consumption-and-alcohol-related-problems-in-adolescents-and-young-adults
#3
REVIEW
Brenda L Curtis, Samantha J Lookatch, Danielle E Ramo, James R McKay, Richard S Feinn, Henry R Kranzler
Despite the pervasive use of social media by young adults, there is comparatively little known about whether, and how, engagement in social media influences this group's drinking patterns and risk of alcohol-related problems. We examined the relations between young adults' alcohol-related social media engagement (defined as the posting, liking, commenting, and viewing of alcohol-related social media content) and their drinking behavior and problems. We conducted a systematic review and meta-analysis of studies evaluating the association of alcohol consumption and alcohol-related problems with alcohol-related social media engagement...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786868/cis-acting-allele-specific-expression-ase-differences-induced-by-alcohol-and-impacted-by-sex-as-well-as-parental-genotype-of-origin
#4
Chiao-Ling Lo, Lawrence Lumeng, Richard L Bell, Tiebing Liang, Amy C Lossie, Williams M Muir, Feng C Zhou
BACKGROUND: Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high and low alcohol drinking (HAD and LAD) rat lines. Here we report allele specific expression (ASE) differences, between the HAD2 and LAD2 rat lines. METHODS: The HAD2 and LAD2 rats which have been sequenced were reciprocally crossed to generate 10 litters of F1 progeny...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29785393/monitoring-methotrexate-induced-liver-fibrosis-in-patients-with-psoriasis-utility-of-transient-elastography
#5
REVIEW
Harriet S Cheng, Marius Rademaker
Increasingly, existing evidence indicates that methotrexate-associated liver injury is related to comorbid risk factors such as diabetes, alcoholism, and obesity, rather than to methotrexate itself. Despite this fact, significant effort continues to be expended in the monitoring of low-dose methotrexate in patients with psoriasis. The gold standard investigation has been liver biopsy, but this is associated with significant morbidity and mortality. As methotrexate-induced liver injury is uncommon, the risk/benefit ratio of liver biopsy has been questioned...
2018: Psoriasis: Targets and Therapy
https://www.readbyqxmd.com/read/29783916/unraveling-the-personality-profile-of-the-sexual-murderer
#6
Eric Beauregard, Matt DeLisi
Although sexual homicide offenders (SHOs) evince personality disorders, few prior studies have examined all personality disorders or utilized control groups of offenders. Drawing on data from 616 adult male sex offenders including 85 who were SHOs, the current study examined the personality profile of the SHOs, by comparing them with a group of violent nonhomicidal sex offenders (VNHSOs) and a group of nonhomicidal sex offenders (NHSOs) on clinical diagnostics of personality disorders and various crime characteristics...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29783094/the-relation-of-parent-alcohol-disorder-to-young-adult-drinking-outcomes-mediated-by-parenting-effects-of-developmentally-limited-versus-persistent-parent-alcohol-disorder
#7
Ariel Sternberg, Danielle Pandika, Kit K Elam, Laurie Chassin
BACKGROUND: Parent alcohol use disorder (AUD) is a well-established risk factor for the development of offspring AUD and is associated with poor parenting. However, few studies have examined heterogeneity in trajectories of parental AUD and its influence on adolescent offspring drinking, and no studies to date have considered the differential risk to offspring conferred by parental AUDs that are limited to early adulthood. Specifically, AUDs limited to the period of emerging adulthood may confer less risk to a child's environment as recovery following emerging adulthood coincides with the typical ages of entry into the parenting role...
April 25, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29781884/extended-release-naltrexone-improves-viral-suppression-levels-in-prisoners-with-hiv-and-alcohol-use-disorders-who-are-transitioning-to-the-community-results-from-a-double-blind-placebo-controlled-trial
#8
Sandra A Springer, Angela Di Paola, Russell Barbour, Marwan M Azar, Frederick L Altice
OBJECTIVE: To determine if extended-release naltrexone (XR-NTX) would improve or maintain viral suppression (VS) among incarcerated individuals with HIV and alcohol use disorders (AUDs) transitioning to the community. DESIGN: A randomized double-blind, placebo-controlled trial was conducted among incarcerated individuals with HIV and AUDs transitioning to the community from 2010 through 2016. METHODS: Eligible participants (N=100) were randomized 2:1 to receive 6 monthly injections of XR-NTX (n=67) or Placebo (n=33) starting at release and continued for 6 months...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781683/tuberculosis-non-communicable-disease-comorbidity-and-multimorbidity-in-public-primary-care-patients-in-south-africa
#9
Karl Peltzer
BACKGROUND:  Little is known about the prevalence of non-communicable disease (NCD) multimorbidity among tuberculosis (TB) patients in Africa.Aim and setting: The aim of this study was to assess the prevalence of NCD multimorbidity, its pattern and impact on adverse health outcomes among patients with TB in public primary care in three selected districts of South Africa. METHODS:  In a cross-sectional survey, new TB and TB retreatment patients were interviewed, and medical records assessed in consecutive sampling within 1 month of anti-TB treatment...
April 11, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29781627/triple-trajectories-of-alcohol-use-tobacco-use-and-depressive-symptoms-as-predictors-of-cannabis-use-disorders-among-urban-adults
#10
Jung Yeon Lee, Judith S Brook, Wonkuk Kim
Heavy cannabis use is associated with a wide array of physical, mental, and functional problems. Therefore, cannabis use disorders (CUDs) may be a major public health concern. Given the adverse health consequences of CUDs, the present study seeks to find possible precursors of CUDs. The current study consisted of 5 waves of data collection from the Harlem Longitudinal Development Study. Among 816 participants, about half are African Americans (52%), and the other half are Puerto Ricans (48%). We used Mplus to obtain the triple trajectories of alcohol use, tobacco use, and depressive symptoms...
May 21, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29779991/mechanical-metatarsalgia-as-a-risk-factor-for-relapse-of-morton-s-neuroma-after-ultrasound-guided-alcohol-injection
#11
Paolo Lorenzon, Carlo Rettore
Although many treatment modalities are available for Morton's neuroma, the injection of the neuroma with alcohol has gained popularity. However, recently, some investigators have observed a progressive deterioration in pain scores for patients initially pain free after the treatment. The purpose of the present retrospective comparative study was to determine whether mechanical metatarsalgia is related to symptom recurrence. We included 104 consecutive cases of ultrasound-guided alcohol injection for Morton's neuroma in 92 patients...
May 17, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29779198/redeveloping-substance-abuse-treatment-for-military-personnel
#12
REVIEW
Christian Schrader, Antoinette Lenton, Peter Gertonson, Alexander Rahimi
PURPOSE OF REVIEW: We review the prevailing evidence surrounding treatment of substance use disorder (SUD), with specific focus on alcohol, tobacco, and prescription opiates, and how it informs guidelines for treating active duty military. We survey the evidence regarding preventive screening, treatment, and relapse prevention in substance misuse as it pertains to patient-centered care of the service member. RECENT FINDINGS: Holistic, patient-centered care with an emphasis on identifying maladaptive use or dependence prior to progression to chronic disease is now recognized as the evidenced approach to treating substance use disorders...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778771/do-serum-markers-of-liver-fibrosis-vary-by-hcv-infection-in-patients-with-alcohol-use-disorder
#13
Arantza Sanvisens, Alvaro Muñoz, Ferran Bolao, Paola Zuluaga, Magí Farré, Inmaculada Jarrin, Jordi Tor, Roberto Muga
INTRODUCTION: HCV infection is frequent in patients with alcohol use disorder (AUD). Ethanol and hepatitis C have a synergistic effect that increases the risk of end-stage liver disease. We aimed to assess fibrosis of the liver in patients admitted to treatment of AUD. METHODS: Data were collected in two hospital units between 2000 and 2014. Liver fibrosis was assessed by serum biomarkers APRI, FIB-4 and Forns, and Advanced Liver Fibrosis (ALF) was defined if APRI > 1...
May 16, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29778286/-epidemiology-of-alcohol-dependence
#14
Xavier Laqueille, Marjorie Lacombe, Alain Dervaux
Excessive alcohol consumption is the second leading preventable cause of death in France (49,000/year), after tobacco consumption. Several recent studies found that the alcohol-related negative health consequences may occurs with small amounts of alcohol, in particular cancers. Therefore, the risk thresholds for alcohol consumption have been recently recommended not to be higher than 100g/week. Early age of onset of alcohol use is a strong predictor of alcohol use disorders and alcohol-related negative health outcomes...
May 16, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29778070/high-intensity-binge-drinking-is-associated-with-alterations-in-spontaneous-neural-oscillations-in-young-adults
#15
Rifqi O Affan, Siyuan Huang, Stephen M Cruz, Lee A Holcomb, Edward Nguyen, Ksenija Marinkovic
Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23.4 ± 3.4 years of age) were assigned to binge drinking (BD) and light drinking (LD) groups that were equated on gender, race/ethnic identity, age, educational background, and family history of alcoholism...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29777967/rates-and-correlates-of-disordered-eating-among-women-veterans-in-primary-care
#16
Laura J Buchholz, Paul R King, Laura O Wray
Rates of disordered eating may be higher among women veterans than civilians, and are associated with co-occurring mental health (MH) conditions, such as depression, post-traumatic stress disorder (PTSD), and alcohol misuse. Although evidence suggests that these conditions are common in primary care settings, limited research has examined symptoms of disordered eating among women veterans in primary care. This study used a cross-sectional design to examine rates and MH correlates of disordered eating among women veterans treated in a primary care setting...
May 16, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29777460/a-tale-of-two-countries-comparing-disability-weights-for-gambling-problems-in-new-zealand-and-australia
#17
Vijay Rawat, Matthew Browne, Maria Bellringer, Nancy Greer, Komathi Kolandai-Matchett, Matthew Rockloff, Erika Langham, Christine Hanley, Katie Palmer Du Preez, Max Abbott
PURPOSE: This study aimed to assess the impact of gambling problems on quality of life. Specifically, we generated disability weight estimates for gambling problems in New Zealand, and compared these results with (i) Australian figures (J Gambl Issues, 10.4309/jgi.v0i36.3978, 2017) and (ii) other health states (Lancet, 10.1016/S0140-6736(12)61680-8, 2013); such as anxiety and alcohol use disorders. METHOD: The 324 participants (48 experts and 276 general population members) evaluated a series of gambling harm vignettes...
May 17, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29777199/influence-of-alcoholism-and-cholesterol-on-tspo-binding-in-brain-pet-11-c-pbr28-studies-in-humans-and-rodents
#18
Sung Won Kim, Corinde E Wiers, Ryan Tyler, Ehsan Shokri-Kojori, Yeon Joo Jang, Amna Zehra, Clara Freeman, Veronica Ramirez, Elsa Lindgren, Gregg Miller, Elizabeth A Cabrera, Tyler Stodden, Min Guo, Şükrü B Demiral, Nancy Diazgranados, Luke Park, Jeih-San Liow, Victor Pike, Cheryl Morse, Leandro F Vendruscolo, Robert B Innis, George F Koob, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow
Neuroinflammation appears to contribute to neurotoxicity observed with heavy alcohol consumption. To assess whether chronic alcohol results in neuroinflammation we used PET and [11 C]PBR28, a ligand that binds to the 18-kDa translocator protein (TSPO), to compare participants with an alcohol use disorder (AUD: n = 19) with healthy controls (HC: n = 17), and alcohol-dependent (n = 9) with -nondependent rats (n = 10). Because TSPO is implicated in cholesterol's transport for steroidogenesis, we investigated whether plasma cholesterol levels influenced [11 C]PBR28 binding...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29776800/risk-of-emergency-hospital-admission-in-children-associated-with-mental-disorders-and-alcohol-misuse-in-the-household-an-electronic-birth-cohort-study
#19
Shantini Paranjothy, Annette Evans, Amrita Bandyopadhyay, David Fone, Behnaz Schofield, Ann John, Mark A Bellis, Ronan A Lyons, Daniel Farewell, Sara Jayne Long
BACKGROUND: Mental disorders and alcohol misuse are common in families but their effects on the physical health of children are not known. We investigated the risk of emergency hospital admissions during childhood associated with living with an adult who has a mental health disorder, or who had an alcohol-related hospital admission. METHODS: We did this cohort study in a total population electronic child cohort in Wales, UK, which includes all children who live in Wales or with a mother who is resident in Wales...
May 15, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29776789/transdiagnostic-effects-of-ventromedial-prefrontal-cortex-transcranial-magnetic-stimulation-on-cue-reactivity
#20
Tonisha E Kearney-Ramos, Logan T Dowdle, Daniel H Lench, Oliver J Mithoefer, William H Devries, Mark S George, Raymond F Anton, Colleen A Hanlon
BACKGROUND: Elevated frontal and striatal reactivity to drug cues is a transdiagnostic hallmark of substance use disorders. The goal of these experiments was to determine if it is possible to decrease frontal and striatal reactivity to drug cues in both cocaine users and heavy alcohol users through continuous theta burst stimulation (cTBS) to the left ventromedial prefrontal cortex (VMPFC). METHODS: Two single-blinded, within-subject, active sham-controlled experiments were performed wherein neural reactivity to drug/alcohol cues versus neutral cues was evaluated immediately before and after receiving real or sham cTBS (110% resting motor threshold, 3600 pulses, Fp1 location; N = 49: 25 cocaine users [experiment 1], 24 alcohol users [experiment 2]; 196 total functional magnetic resonance imaging scans)...
April 10, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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