Kiuanne Lino Lobo Metzker, Khiany Mathias, Richard Simon Machado, Sandra Bonfante, Larissa Joaquim, Marina Goulart da Silva, Guilherme Cabreira Daros, Elisa Mitkus Flores Lins, Fernanda Belle, Carolina Giassi Alano, Rafaela Tezza Matiola, Isabela da Silva Lemos, Lucinéia Gainski Danielski, Fernanda Frederico Gava, Rafael Mariano de Bitencourt, Franciane Bobinski, Emilio Luiz Streck, Gislaine Zilli Reus, Fabricia Petronilho
BACKGROUND: In response to inflammation and other stressors, tryptophan is catalyzed by Tryptophan 2,3-Dioxygenase (TDO), which leads to activation of the kynurenine pathway. Sepsis is a serious condition in which the body responds improperly to an infection, and the brain is the inflammation target in this condition. OBJECTIVE: This study aimed to determine if the induction of TDO contributes to the permeability of the Blood-Brain Barrier (BBB), mortality, neuroinflammation, oxidative stress, and mitochondrial dysfunction, besides long-term behavioral alterations in a preclinical model of sepsis...
May 6, 2024: CNS & Neurological Disorders Drug Targets