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https://www.readbyqxmd.com/read/29668078/adherence-and-immune-response-to-revaccination-following-hematopoietic-stem-cell-transplantation-at-a-pediatric-onco-hematology-reference-center
#1
Fernanda Gouveia-Alves, Roseane Gouveia, Valéria C Ginani, Adriana Seber, Danielle A Kuramoto, Gabriel F A Murad, Fernanda G Spina, Antonio S Petrilli, Victor G Zecchin, Celso Granato, Fabianne Carlesse, M Isabel de Moraes-Pinto
BACKGROUND: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients. METHODS: Patients submitted to HSCT for over 3 years were recruited. After written informed consent, a questionnaire was filled in, the vaccination card was analyzed, a blood sample was collected and tested by ELISA for diphtheria, Haemophilus influenzae type b (Hib), hepatitis A, hepatitis B, tetanus, measles, rubella and varicella antibodies...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667706/preliteracy-impairments-in-children-with-neurofibromatosis-type-1
#2
Shelley S Arnold, Jonathan M Payne, Jennifer Lorenzo, Kathryn N North, Belinda Barton
AIM: This cross-sectional study aimed to examine the preliteracy abilities of young children with neurofibromatosis type 1 (NF1) and to identify which of these abilities best predicted conventional literacy (spelling). METHOD: Forty-two children with NF1 (23 males, 19 females; mean age [SD] 5y 6mo [6mo]) were compared with 32 unaffected children (15 males, 17 females; mean age [SD] 5y 4mo [6mo]). All children completed a comprehensive cognitive assessment including measures of phonological processing (phonological awareness, phonological memory, rapid automatic naming) and letter-sound knowledge...
April 18, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29667572/neurobiological-findings-associated-with-high-cognitive-performance-in-older-adults-a-systematic-review
#3
Wyllians Vendramini Borelli, Lucas Porcello Schilling, Graciane Radaelli, Luciana Borges Ferreira, Leonardo Pisani, Mirna Wetters Portuguez, Jaderson Costa da Costa
ABSTRACTObjectives:to perform a comprehensive literature review of studies on older adults with exceptional cognitive performance. DESIGN: We performed a systematic review using two major databases (MEDLINE and Web of Science) from January 2002 to November 2017. RESULTS: Quantitative analysis included nine of 4,457 studies and revealed that high-performing older adults have global preservation of the cortex, especially the anterior cingulate region, and hippocampal volumes larger than normal agers...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667564/the-recency-ratio-as-predictor-of-early-mci
#4
Davide Bruno, Rebecca L Koscik, John L Woodard, Nunzio Pomara, Sterling C Johnson
ABSTRACTObjectives:Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967-973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667495/common-transdiagnostic-cognitive-deficits-among-people-with-psychiatric-disorders-exposed-to-childhood-maltreatment-a-meta-analysis
#5
Alexandra R-Mercier, Marjolaine Masson, Eve-Line Bussières, Caroline Cellard
INTRODUCTION: Previous meta-analyses have shown a moderate negative impact of maltreatment on the neuropsychological functioning of people with or without psychiatric disorders compared to healthy groups. The objectives of the present meta-analysis were to (1) investigate the impact of maltreatment on neuropsychological functioning of people with psychiatric disorders and to (2) evaluate the moderating effect of age, at the time of the cognitive assessment, on neuropsychological functioning...
April 18, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29667477/return-to-work-after-severe-traumatic-brain-injury-a-national-study-with-a-one-year-follow-up-of-neurocognitive-and-behavioural-outcomes
#6
Solrun Sigurdardottir, Nada Andelic, Eike Wehling, Audny Anke, Toril Skandsen, Oyvor Oistensen Holthe, Unn Sollid Manskow, Cecilie Roe
The objectives were to investigate the frequency of return-to-work (RTW) one year after severe traumatic brain injury (sTBI: Glasgow Coma Scale, GCS 3-8) and to identify which demographic and injury-related characteristics and neurocognitive factors are associated with RTW. This study is part of a prospective national study on sTBI conducted in all four Norwegian Trauma Referral Centres, including patients aged >15 years over a period of three years (n = 378). For the purpose of this study, only pre-employed individuals of working age (16 to 67 years) were investigated for RTW (n = 143), and of these, 104 participants underwent neuropsychological testing...
April 18, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#7
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667271/syndrome-and-outcome-of-antibody-negative-limbic-encephalitis
#8
Francesc Graus, Domingo Escudero, Laura Oleaga, Jordi Bruna, Alberto Villarejo-Galende, Jordi Ballabriga, María Inés Barceló, Francisco Gilo, Stoyan Popkirov, Pavel Stourac, Josep Dalmau
OBJECTIVE: To report the clinical characteristics of 12 patients with limbic encephalitis (LE) who were antibody-negative after a comprehensive immunological study. METHODS: Review of clinical records of 163 patients with LE. Immunohistochemistry on rat brain, cultured neurons, and cell-based assays were used to identify neuronal autoantibodies. Patients were included if 1) there was adequate clinical, CSF, and MRI information to classify the syndrome as LE, 2) MRI images were accesible for central review, and 3) serum and CSF were available and confirmed negative for neuronal antibodies...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29667159/physical-activity-throughout-the-adult-life-span-and-domain-specific-cognitive-function-in-old-age-a-systematic-review-of-cross-sectional-and-longitudinal-data
#9
REVIEW
Tobias Engeroff, Tobias Ingmann, Winfried Banzer
BACKGROUND: A growing body of literature suggests that physical activity might alleviate the age-related neurodegeneration and decline of cognitive function. However, most of this evidence is based on data investigating the association of exercise interventions or current physical activity behavior with cognitive function in elderly subjects. OBJECTIVE: We performed a systematic review and hypothesize that physical activity during the adult life span is connected with maintained domain-specific cognitive functions during late adulthood defined as age 60+ years...
April 17, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29667132/obesity-and-episodic-memory-function
#10
REVIEW
Paul D Loprinzi, Emily Frith
Obesity-related lifestyle factors, such as physical activity behavior and dietary intake, have been shown to be associated with episodic memory function. From animal work, there is considerable biological plausibility linking obesity with worse memory function. There are no published systematic reviews evaluating the effects of obesity on episodic memory function among humans, and examining whether physical activity and diet influences this obesity-memory link. Thus, the purpose of this systematic review was to evaluate the totality of research examining whether obesity is associated with episodic memory function, and whether physical activity and dietary behavior confounds this relationship...
April 17, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29665578/brain-morphology-cognition-and-%C3%AE-amyloid-in-older-adults-with-superior-memory-performance
#11
Theresa M Harrison, Anne Maass, Suzanne L Baker, William J Jagust
The mechanisms underlying superior cognitive performance in some older adults are poorly understood. We used a multimodal approach to characterize imaging and cognitive features of 26 successful agers (SA; defined by superior episodic memory ability) and 103 typical older adults. Cortical thickness was greater in multiple regions in SA including right anterior cingulate and prefrontal cortex and was related to baseline memory performance. Similarly, hippocampal volume was greater in SA and associated with baseline memory...
March 27, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29665519/associations-between-cognitive-functioning-mood-symptoms-and-coping-styles-in-older-age-bipolar-disorder
#12
Nadine P G Paans, Annemiek Dols, Hannie C Comijs, Max L Stek, Sigfried N T M Schouws
BACKGROUND: Older age patients with bipolar disorder (OABD) have often passive coping styles, generally considered as detrimental for functioning. The aim of the current study is to identify the contribution of cognitive functioning, subjective cognitive complaints and mood symptoms to passive and active coping styles in older age BD. METHODS: In 90 euthymic patients (age > 60) with BD I or II, we examined coping, neuropsychological profile including memory, attention, executive function and fluency, subjective cognitive complaints and mood symptoms...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665283/accelerated-executive-functions-decline-and-gray-matter-structural-changes-in-middle-aged-type-1-diabetes-patients-with-proliferative-retinopathy
#13
Eelco van Duinkerken, Martijn D Steenwijk, Martin Klein, Frederik Barkhof, Daniel C Mograbi, Michaela Diamant, Frank J Snoek, Richard G Ijzerman
BACKGROUND: The aim of this study was to determine trajectories of cognitive and cortical changes over time in middle-aged patients with type 1 diabetes and proliferative retinopathy. METHODS: Twenty-five patients and 25 controls underwent neuropsychological assessment and neuroimaging twice in 3.56 ± 0.65 and 3.94 ± 0.91 years respectively (P = 0.098). Cognitive assessment included the domains of general cognitive ability, memory, information processing speed, executive functions, attention, motor and psychomotor speed...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#14
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29664932/obesity-and-unhealthy-lifestyle-associated-with-poor-executive-function-among-malaysian-adolescents
#15
Joyce Ying Hui Tee, Wan Ying Gan, Kit-Aun Tan, Yit Siew Chin
The understanding on the roles of obesity and lifestyle behaviors in predicting executive function of adolescents has been limited. Low executive function proficiency may have adverse effects on adolescents' school academic performance. This cross-sectional study aimed to examine the relationship between BMI-for-age and multiple lifestyle behaviors (operationalized as meal consumption, physical activity, and sleep quality) with executive function (operationalized as inhibition, working memory, and cognitive flexibility) on a sample of Malaysian adolescents aged between 12 and 16 years (N = 513)...
2018: PloS One
https://www.readbyqxmd.com/read/29664577/the-gradual-rise-of-memory-inflation
#16
REVIEW
Paul Klenerman
Memory inflation, as a term, has been used for 15 years now to describe the longitudinal development of stable, expanded CD8+ T memory pools with a distinct phenotype and functional profile which emerge in specific infection and vaccine settings. These settings have in common the persistence of antigen, especially cytomegalovirus infection but also more recently adenoviral vector vaccination. However, in contrast to chronic infections which lead to "exhaustion" the repeated antigen encounters experienced by CD8+ T cells lead to development of a robust T-cell population structure which maintains functionality and size...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29664048/effect-of-rapid-eye-movement-sleep-behavior-disorder-on-obstructive-sleep-apnea-severity-and-cognition-of-parkinson-s-disease-patients
#17
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29664047/association-of-source-of-memory-complaints-and-increased-risk-of-cognitive-impairment-and-cognitive-decline-a-community-based-study
#18
Xue-Mei Qi, Lin Gu, Hui-Dong Tang, Sheng-Di Chen, Jian-Fang Ma
Background: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a community-based cohort. Methods: Data on memory complaints and cognitive function were collected among 1840 Chinese participants (aged ≥55 years old) in an urban community at baseline interview and 5-year follow-up...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663819/immunosenescence-the-role-in-the-immunotherapy-of-older-population
#19
M Prcina, M Novak, V Cigankova, E Kontsekova
With ageing of their populations, many societies are challenged with serious systemic diseases. One of the causes of these diseases could be the age-related defects in immune system termed immunosenescence. Immunosenescence is characterized by accumulation of memory and non-functional immune cells, impaired signalling due to restricted repertoire of receptors, overall pro-inflammatory environment and complete dysregulation of the immune system. Consequences of immunosenescence are serious, older people are not able to respond to new stimuli, including infections and vaccinations and are more prone to oncologic, neurodegenerative and autoimmune diseases (Ref...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29663599/greater-caregiving-risk-better-infant-memory-performance
#20
Anne Rifkin-Graboi, Jeffry Quan, Jenny Richmond, Shaun Kok Yew Goh, Lit Wee Sim, Yap Seng Chong, Jean Francois-Bureau, Helen Chen, Anqi Qiu
Poor early life care often relates to cognitive difficulties. However, newer work suggests that in early-life, adversity may associate with enhanced or accelerated neurodevelopment. We examine associations between postnatal caregiving risks (i.e., higher self-reported postnatal-anxiety and lower observed maternal sensitivity) and infant relational memory (i.e. via deferred imitation and relational binding). Using subsamples of 67-181 infants (aged 433-477 post-conceptual days, or roughly five to seven months since birth) taking part in the GUSTO study, we found such postnatal caregiving risk significantly predictive of "better" performance on a relational binding task following a brief delay, after Bonferroni adjustments...
April 16, 2018: Hippocampus
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