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https://www.readbyqxmd.com/read/29036849/newly-developed-learning-and-verbal-memory-test-tamv-i-normative-data-for-spanish-speaking-pediatric-population
#1
D Rivera, L Olabarrieta-Landa, B V Rabago Barajas, M J Irías Escher, M Saracostti Schwartzman, R Ferrer-Cascales, P Martín-Lobo, J A Calderón, M A Aguilar Uriarte, A I Peñalver Guia, R Camlla Ynga, C E García-Guerrero, I Fernandez-Agis, A García-Gómez-Pastrana, J A Ibañéz-Alfonso, H Gómez, J Galarza-Del-Angel, C García de la Cadena, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Learning and Verbal Memory Test (TAMV-I) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TAMV-I as part of a larger neuropsychological battery. Free recall, memory delay and recognition scores were normed using multiple linear regressions and standard deviations of residual values...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036822/cortical-cerebral-microinfarcts-on-3-tesla-mri-in-patients-with-vascular-cognitive-impairment
#2
Doeschka A Ferro, Susanne J van Veluw, Huiberdina L Koek, Lieza G Exalto, Geert Jan Biessels
BACKGROUND: Cerebral microinfarcts (CMIs) are small ischemic lesions that are a common neuropathological finding in patients with stroke or dementia. CMIs in the cortex can now be detected in vivo on 3 Tesla MRI. OBJECTIVE: To determine the occurrence of CMIs and associated clinical features in patients with possible vascular cognitive impairment (VCI). METHOD: 182 memory-clinic patients (mean age 71.4±10.6, 55% male) with vascular injury on brain MRI (i...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#3
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036636/genetic-reduction-of-nrf2-exacerbates-cognitive-deficits-in-a-mouse-model-of-alzheimer-s-disease
#4
Caterina Branca, Eric Ferreira, Thuy-Vi Nguyen, Kristian Doyle, Antonella Caccamo, Salvatore Oddo
Aging is the major risk factor for several neurodegenerative diseases, including Alzheimer's disease (AD). However, the mechanisms by which aging contributes to neurodegeneration remain elusive. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor that regulates expression of a vast number of genes by binding to the antioxidant response element. Nrf2 levels decrease as a function of age, and reduced Nrf2 levels have been reported in postmortem human brains and animal models of AD...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036201/impact-of-social-separation-during-pregnancy-on-the-manifestation-of-defensive-behaviors-related-to-generalized-anxiety-and-panic-throughout-offspring-development
#5
Flaviane Cristina de Brito Guzzo Soliani, Rafael Cabbia, Matheus Fitipaldi Batistela, Amarylis Garcia Almeida, Vinícius Dias Kümpel, Luiz Yamauchi Junior, Telma Gonçalves Carneiro Spera de Andrade
The multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring's anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny's assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life)...
2017: PloS One
https://www.readbyqxmd.com/read/29035740/memory-age-identity-as-a-predictor-of-cognitive-function-in-the-elderly-a-2-year-follow-up-study
#6
Ki Jung Chang, Chang Hyung Hong, Yun Hwan Lee, Young Ki Chung, Ki Young Lim, Jai Sung Noh, Jin-Ju Kim, Haena Kim, Hyun-Chung Kim, Sang Joon Son
BACKGROUND: There is a growing interest in finding psychosocial predictors related to cognitive function. In our previous research, we conducted a cross-sectional study on memory age identity (MAI) and found that MAI might be associated with objective cognitive performance in non-cognitively impaired elderly. A longitudinal study was conducted to better understand the importance of MAI as a psychosocial predictor related to objective cognitive function. METHODS: Data obtained from 1345 Korean subjects aged 60 years and above were analyzed...
October 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29035066/multiple-self-reported-sleep-measures-are-differentially-associated-with-cognitive-performance-in-community-dwelling-nondemented-elderly
#7
John P K Bernstein, Matthew Calamia, Jeffrey N Keller
OBJECTIVE: To examine associations between daytime and insomnia-related sleep problems with different domains of cognitive functioning and determine whether subclinical depressive symptoms and age moderate these associations. METHOD: A total of 903 cognitively healthy older adults enrolled in a longitudinal aging study completed the UDS neuropsychological battery (measuring attention, executive functioning, episodic memory, language and processing speed). Subclinical depressive symptoms were also assessed and self-reported measures of sleep were administered...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29034489/modification-of-automatic-alcohol-approach-tendencies-in-alcohol-dependent-patients-with-mild-or-major-neurocognitive-disorder
#8
Anke Loijen, Mike Rinck, Serge J W Walvoort, Roy P C Kessels, Eni S Becker, Jos I M Egger
BACKGROUND: To examine the applicability of an alcohol-avoidance training procedure in patients with alcohol dependence and alcohol-induced neurocognitive disorders, we trained two groups that differed in the degree of cognitive impairment: One group fulfilled the DSM-5 criteria for Alcohol-Induced Mild Neurocognitive Disorder, and one group was diagnosed with Korsakoff's syndrome (Alcohol-Induced Major Neurocognitive Disorder, Confabulatory/Amnesic subtype; DSM-5). The intervention is assumed to match the preserved cognitive capacity for implicit learning in both groups...
October 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29034441/the-oral-pretreatment-of-glycyrrhizin-prevents-surgery-induced-cognitive-impairment-in-aged-mice-by-reducing-neuroinflammation-and-alzheimer-s-related-pathology-via-hmgb1-inhibition
#9
Zhong-Hong Kong, Xin Chen, Hui-Po Hua, Liang Liang, Long-Juan Liu
Neuroinflammation and Alzheimer's-related pathology play essential roles in postoperative cognitive dysfunction (POCD). High-mobility group box 1 (HMGB1) is well known as a pivotal mediator in neuroinflammation, and its associations with Alzheimer's-related pathology and POCD have been also revealed. Glycyrrhizin is a nature inhibitor of HMGB1 and is reported with neuroprotective effects through oral administration. Therefore, the present study aims to test the hypothesis that the oral pretreatment of glycyrrhizin prevents POCD by inhibiting HMGB1-induced neuroinflammation and Alzheimer's-related pathology in aged mice...
October 16, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29034310/further-education-improves-cognitive-reserve-and-triggers-improvement-in-selective-cognitive-functions-in-older-adults-the-tasmanian-healthy-brain-project
#10
Megan E Thow, Mathew J Summers, Nichole L Saunders, Jeffery J Summers, Karen Ritchie, James C Vickers
INTRODUCTION: The strong link between early-life education and subsequent reduced risk of dementia suggests that education in later life could enhance cognitive function and may reduce age-related cognitive decline and protect against dementia. METHODS: Episodic memory, working memory, executive function, and language processing performances were assessed annually over 4 years in 359 healthy older adults who attended university for a minimum of 12 months (intervention) and were compared against 100 healthy adult controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29033974/cognitive-deficits-in-chronic-stroke-patients-neuropsychological-assessment-depression-and-self-reports
#11
Arne E Nakling, Dag Aarsland, Halvor Næss, Daniel Wollschlaeger, Tormod Fladby, Håkon Hofstad, Eike Wehling
BACKGROUND: Following stroke, clinicians are challenged to detect and untangle symptoms of cognitive dysfunction and mood disorders. Additionally, they need to evaluate the informative value of self-reports to identify patients in need of further attendance. AIMS: To examine the association between neuropsychological measures, symptoms of depression, and self-reported cognitive function. METHODS: One-hundred and five chronic stroke patients underwent assessment covering 6 cognitive domains and answered the Hospital Anxiety and Depression Scale and the Memory and Thinking Scale from the Stroke Impact Scale 1 year after stroke...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29033801/heavy-drinking-in-college-students-is-associated-with-accelerated-gray-matter-volumetric-decline-over-a-2-year-period
#12
Shashwath A Meda, Alecia D Dager, Keith A Hawkins, Howard Tennen, Sarah Raskin, Rebecca M Wood, Carol S Austad, Carolyn R Fallahi, Godfrey D Pearlson
Background: Heavy and/or harmful alcohol use while in college is a perennial and significant public health issue. Despite the plethora of cross-sectional research suggesting deleterious effects of alcohol on the brain, there is a lack of literature investigating the longitudinal effects of alcohol consumption on the adolescent brain. We aim to probe the longitudinal effects of college drinking on gray matter change in students during this crucial neurodevelopmental period. Methods: Data were derived from the longitudinal Brain and Alcohol Research in College Students (BARCS) study of whom a subset underwent brain MRI scans at two time points 24 months apart...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29033637/cognitive-functioning-in-euthymic-bipolar-patients-on-monotherapy-with-novel-antipsychotics-or-mood-stabilizers
#13
Vesile Şentürk Cankorur, Hilal Demirel, Cem Atbaşoğlu
INTRODUCTION: Bipolar disorder is associated with cognitive dysfunction in several domains. Medication effect is a potential confounder that can only be statistically controlled in many studies. The cognitive profile in bipolar disorder during remission on maintenance antipsychotics or mood stabilizers medication has not been compared before. METHODS: We compared the cognitive profile of bipolar disorder patients euthymic for 2 month or more on monotherapy with novel antipsychotics (AP) (n=16), lithium carbonate (Li) (n=25) or valproic acid (VPA; n=26)...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29033604/chronic-pain-and-adult-hippocampal-neurogenesis-translational-implications-from-preclinical-studies
#14
Mariagrazia Grilli
Adult hippocampal neurogenesis (ahNG) occurs in the human brain. Adult generated neurons have been proposed to functionally contribute to relevant hippocampal functions such as learning and memory, mood regulation, and stress response. Learning, environmental enrichment, and physical exercise exert positive effects on ahNG. In parallel, these proneurogenic stimuli have been shown to ameliorate cognitive performance and/or depressive-like behavior in animal models. Conversely, aging, social isolation, and chronic stress exert negative effects on ahNG...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033450/a-retrospective-chart-analysis-with-follow-up-of-cogmed-working-memory-training-in-children-and-adolescents-with-autism-spectrum-disorder
#15
Sander M Weckstein, Ethan J Weckstein, Christopher D Parker, Matthew W Westerman
BACKGROUND This case study was undertaken in an effort to assess whether children/adolescents with Autism Spectrum Disorder (ASD) experience improvement in comorbid ADHD following Cogmed Working Memory Training (CWMT). This treatment intervention has been shown to improve ADHD symptoms in children and adolescents; however, there have been no studies on its use with individuals with ASD. MATERIAL AND METHODS CWMT is a computer-based program that consists of 13 auditory, visual, visual spatial, and combined exercises that are practiced for 45 minutes a day, 5 days a week, for 5 weeks...
October 16, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29033017/neurocognitive-and-psychological-outcomes-in-adults-with-dextro-transposition-of-the-great-arteries-corrected-by-the-arterial-switch-operation
#16
Leïla Kasmi, Johanna Calderon, Michèle Montreuil, Nikoletta Geronikola, Virginie Lambert, Emrè Belli, Damien Bonnet, David Kalfa
BACKGROUND: Neurodevelopmental impairments have frequently been described in children and adolescents with dextro-transposition of the great arteries (d-TGA). The arterial switch operation (ASO) to correct d-TGA has been used for more than 30 years, and more than 90% of these patients now reach adulthood. However, very little is known about their long-term functional outcomes. The present study investigated neurocognitive outcomes and the prevalence of psychiatric disorders in adults with d-TGA corrected by ASO...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29032807/a-comparison-of-the-severe-cognitive-impairment-rating-scale-with-the-mini-mental-state-examination-and-delirium-rating-scale-revised-98-for-delirium-a-cross-sectional-study
#17
So-Hyun Ahn, Jin-Hoon Choi, Chae-Sung Im, Tae-Sung Kim, Jeong Lan Kim
BACKGROUND: Cognitive impairment including attention deficits, disorientation, memory impairment, language disturbance, and impaired visuospatial ability are core symptoms of delirium. The Severe Cognitive Impairment Rating Scale (SCIRS) was developed to assess cognition in patients with severe dementia, but may also be useful in elderly people with delirium. OBJECTIVE: We investigated the use of the SCIRS to assess cognition in elderly patients with delirium. METHODS: We recruited 147 participants, aged ≥65 years, referred for psychiatric consultation at a tertiary-care university hospital...
August 5, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29032789/symptom-dimensions-of-depression-and-apathy-and-their-relationship-with-cognition-in-parkinson-s-disease
#18
Sarah M Szymkowicz, Vonetta M Dotson, Jacob D Jones, Michael S Okun, Dawn Bowers
OBJECTIVES: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. METHODS: A sample of 138 non-demented individuals with PD (mean age=64...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29032750/longitudinal-neuropsychological-outcome-in-taiwanese-alzheimer-s-disease-patients-treated-with-medication
#19
Pi-Shan Sung, Meng-Ni Wu, Ping-Song Chou, Hui-Chen Su, Sheng-Hsiang Lin, Yuan-Han Yang
Background The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as measured by commonly used NPTs in treated AD patients and to assess the potential predictors of disease progression. Methods Participants (N=455) diagnosed with AD and treated with cholinesterase inhibitors (ChEIs) or memantine at memory clinics in three hospitals in southern Taiwan from January 2009 to December 2014 were enrolled in this prospectively registered study...
October 10, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29032191/aging-and-a-genetic-kibra-polymorphism-interactively-affect-feedback-and-observation-based-probabilistic-classification-learning
#20
Nicolas W Schuck, Jessica R Petok, Martijn Meeter, Brit-Maren M Schjeide, Julia Schröder, Lars Bertram, Mark A Gluck, Shu-Chen Li
Probabilistic category learning involves complex interactions between the hippocampus and striatum that may depend on whether acquisition occurs via feedback or observation. Little is known about how healthy aging affects these processes. We tested whether age-related behavioral differences in probabilistic category learning from feedback or observation depend on a genetic factor known to influence individual differences in hippocampal function, the KIBRA gene (single nucleotide polymorphism rs17070145). Results showed comparable age-related performance impairments in observational as well as feedback-based learning...
September 5, 2017: Neurobiology of Aging
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