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https://www.readbyqxmd.com/read/29452227/age-and-experience-dependent-changes-in-egr-1-expression-during-the-ontogeny-of-the-context-preexposure-facilitation-effect-cpfe
#1
P A Robinson-Drummer, T Chakraborty, N A Heroux, J B Rosen, M E Stanton
The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which acquisition of the contextual representation and association of the retrieved contextual memory with an immediate foots-hock are separated by 24hrs. During the CPFE, learning- related expression patterns of the early growth response -1 gene (Egr-1) vary based on training phase and brain sub-region in adult and adolescent rats (Asok, Schreiber, Jablonski, Rosen, & Stanton, 2013; Shreiber et al., 2014; Chakraborty, Asok, Stanton, & Rosen, 2016)...
February 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29451027/a-case-of-late-onset-ocd-developing-pls-and-ftd
#2
Enrica Bersano, Maria Francesca Sarnelli, Valentina Solara, Fabiola De Marchi, Gian Mauro Sacchetti, Alessandro Stecco, Lucia Corrado, Sandra D'alfonso, Roberto Cantello, Letizia Mazzini
We describe a 64-year-old woman, suffering from late-onset obsessive-compulsive disorder (OCD) from the age of 57, who developed dysarthria and dysphagia, spastic diplegic, and proximal muscles weakness. Needle electromyography showed no active denervation. Neuropsychological evaluation showed intact cognitive functioning. We diagnosed upper motor neuron disease (MND), with no known genetic correlates. Brain magnetic resonance (MRI) detected bilateral hippocampal atrophy with sclerosis of right hippocampus...
February 16, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29450821/episodic-life-stress-and-the-development-of-overgeneral-autobiographical-memory-to-positive-cues-in-youth
#3
Cope Feurer, Mary L Woody, Aliona Tsypes, Katie L Burkhouse, Katelynn Champagne, Brandon E Gibb
Overgeneral autobiographical memory (OGM) has been established as a risk factor for depression in both youth and adults, but questions remain as to how OGM develops. Although theorists have proposed that the experience of stressful life events may contribute to the development of OGM, no studies have examined the impact of negative life events on prospective changes in OGM. The goal of the current study was to address this gap in the literature. Participants included 251 mothers and their biological children (aged 8-14 years old at the initial assessment)...
February 15, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29450820/overlapping-and-distinct-cognitive-impairments-in-attention-deficit-hyperactivity-and-autism-spectrum-disorder-without-intellectual-disability
#4
Sarah L Karalunas, Elizabeth Hawkey, Hanna Gustafsson, Meghan Miller, Marybeth Langhorst, Michaela Cordova, Damien Fair, Joel T Nigg
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are commonly comorbid, share genetic liability, and often exhibit overlapping cognitive impairments. Clarification of shared and distinct cognitive effects while considering comorbid symptoms across disorders has been lacking. In the current study, children ages 7-15 years assigned to three diagnostic groups:ADHD (n = 509), ASD (n = 97), and controls (n = 301) completed measures spanning the cognitive domains of attention/arousal, working memory, set-shifting, inhibition, and response variability...
February 15, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29450534/reading-behind-the-lines-the-factors-affecting-the-text-reception-threshold-in-hearing-aid-users
#5
Adriana A Zekveld, Marieke Pronk, Henrik Danielsson, Jerker Rönnberg
Purpose: The visual Text Reception Threshold (TRT) test (Zekveld et al., 2007) has been designed to assess modality-general factors relevant for speech perception in noise. In the last decade, the test has been adopted in audiology labs worldwide. The 1st aim of this study was to examine which factors best predict interindividual differences in the TRT. Second, we aimed to assess the relationships between the TRT and the speech reception thresholds (SRTs) estimated in various conditions...
February 13, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29450493/the-impact-of-age-background-noise-semantic-ambiguity-and-hearing-loss-on-recognition-memory-for-spoken-sentences
#6
Margaret A Koeritzer, Chad S Rogers, Kristin J Van Engen, Jonathan E Peelle
Purpose: The goal of this study was to determine how background noise, linguistic properties of spoken sentences, and listener abilities (hearing sensitivity and verbal working memory) affect cognitive demand during auditory sentence comprehension. Method: We tested 30 young adults and 30 older adults. Participants heard lists of sentences in quiet and in 8-talker babble at signal-to-noise ratios of +15 dB and +5 dB, which increased acoustic challenge but left the speech largely intelligible...
February 15, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29449804/an-early-sensitive-period-induces-long-lasting-plasticity-in-the-honeybee-nervous-system
#7
Juan P Grosso, Jesica A Barneto, Rodrigo A Velarde, Eduardo A Pagano, Jorge A Zavala, Walter M Farina
The effect of early experiences on the brain during a sensitive period exerts a long-lasting influence on the mature individual. Despite behavioral and neural plasticity caused by early experiences having been reported in the honeybee Apis mellifera , the presence of a sensitive period in which associative experiences lead to pronounced modifications in the adult nervous system is still unclear. Laboratory-reared bees were fed with scented food within specific temporal windows and were assessed for memory retention, in the regulation of gene expression related to the synaptic formation and in the olfactory perception of their antennae at 17 days of age...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29449458/a-barnes-maze-for-juvenile-rats-delineates-the-emergence-of-spatial-navigation-ability
#8
Daniel G McHail, Nazanin Valibeigi, Theodore C Dumas
The neural bases of cognition may be greatly informed by relating temporally defined developmental changes in behavior with concurrent alterations in neural function. A robust improvement in performance in spatial learning and memory tasks occurs at 3 wk of age in rodents. We reported that the developmental increase of spontaneous alternation in a Y-maze was related to changes in temporal dynamics of fast glutamatergic synaptic transmission in the hippocampus. We also showed that, during allothetic behaviors in the Y-maze, network oscillation power increased at frequency bands known to support spatial learning and memory in adults...
March 2018: Learning & Memory
https://www.readbyqxmd.com/read/29448960/double-negative-cd27-igd-b-cells-are-expanded-in-nsclc-and-inversely-correlate-with-affinity-matured-b-cell-populations
#9
Sara M Centuori, Cecil J Gomes, Samuel S Kim, Charles W Putnam, Brandon T Larsen, Linda L Garland, David W Mount, Jesse D Martinez
BACKGROUND: The presence of B cells in early stage non-small cell lung cancer (NSCLC) is associated with longer survival, however, the role these cells play in the generation and maintenance of anti-tumor immunity is unclear. B cells differentiate into a variety of subsets with differing characteristics and functions. To date, there is limited information on the specific B cell subsets found within NSCLC. To better understand the composition of the B cell populations found in NSCLC we have begun characterizing B cells in lung tumors and have detected a population of B cells that are CD79A + CD27 - IgD - ...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29448874/autobiographical-memory-functions-and-posttraumatic-stress-symptoms-across-adulthood
#10
Adriana Del Palacio-Gonzalez, Lynn A Watson, Dorthe Berntsen
Previous research has documented robust individual differences in the functions served by autobiographical memories, and shown that different autobiographical memory functions are related to both positive and negative indicators of psychological well-being, and that their frequency varies with age. In this study, we examined the unique relationship between autobiographical memory functions and posttraumatic stress symptoms (PTSS) and whether such relationships varied with age across adulthood. A representative sample of 1040 adult Danes (20-70 years old) reported the frequency with which they recall autobiographical memories for different purposes as well as their level of posttraumatic stress disorder (PTSD) symptoms...
February 15, 2018: Memory
https://www.readbyqxmd.com/read/29448288/-apd-in-first-graders-which-tests-discriminate-between-normal-and-impaired-children
#11
Andreas Nickisch, Franziska Werner, Christiane Kiese-Himmel
OBJECTIVE: In a controlled group comparison it was shown for 2nd, 3th and 4th graders that children with auditory processing disorders (APD) could be distinguished from those without (Non-APD) by three to four diagnostic tools. The hit rate was 93.6 % resp. 97.5 % 1, 2. The current study investigated whether such a separation is also possible in first graders. MATERIAL AND METHODS: Performance of 77 first graders in two clinically and diagnostically confirmed groups (n = 40 with APD, mean age: 6...
February 15, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29448234/gene-expression-changes-in-the-ventral-hippocampus-and-medial-prefrontal-cortex-of-adolescent-alcohol-preferring-p-rats-following-binge-like-alcohol-drinking
#12
Jeanette N McClintick, William J McBride, Richard L Bell, Zheng-Ming Ding, Yunlong Liu, Xiaoling Xuei, Howard J Edenberg
Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal cortex volume and deficits in memory. We used RNA sequencing to assess the effects of adolescent binge drinking on gene expression in these regions. Male adolescent alcohol-preferring (P) rats were exposed to repeated binge drinking (three 1-h sessions/day during the dark/cycle, 5 days/week for 3 weeks starting at 28 days of age; ethanol intakes of 2.5-3 g/kg/session)...
September 14, 2017: Alcohol
https://www.readbyqxmd.com/read/29448150/right-prefrontal-cortex-specialization-for-visuospatial-working-memory-and-developmental-alterations-in-prefrontal-cortex-recruitment-in-school-age-children
#13
Kota Suzuki, Yosuke Kita, Yuhei Oi, Yasuko Okumura, Hideyuki Okuzumi, Masumi Inagaki
OBJECTIVE: The right prefrontal cortex (PFC) plays an essential role in active processing within visuospatial working memory (VSWM). The aim of this study was to examine developmental changes in the recruitment patterns of the PFC during visuospatial memory tasks in school-age participants. METHODS: We recruited 80 school-age children who were classified into three age groups: 7- to 8-year-old, 9- to 10-year-old, and 11- to 12-year-old children. We used near infrared spectroscopy (NIRS) to measure PFC activity during visuospatial memory task...
February 12, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29448003/increased-hippocampal-prefrontal-functional-connectivity-in-insomnia
#14
Jeanne Leerssen, Rick Wassing, Jennifer R Ramautar, Diederick Stoffers, Oti Lakbila-Kamal, Joy Perrier, Jessica Bruijel, Jessica C Foster-Dingley, Moji Aghajani, Eus J W van Someren
Insomnia Disorder (ID) is the second-most common mental disorder and has a far-reaching impact on daytime functioning. A meta-analysis indicates that, of all cognitive domains, declarative memory involving the hippocampus is most affected in insomnia. Hippocampal functioning has consistently been shown to be sensitive to experimental sleep deprivation. Insomnia however differs from sleep deprivation in many aspects, and findings on hippocampal structure and function have been equivocal. The present study used both structural and resting-state functional Magnetic Resonance Imaging in a larger sample than previously reported to evaluate hippocampal volume and functional connectivity in ID...
February 12, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29447181/innate-immune-responses-following-kawasaki-disease-and-toxic-shock-syndrome
#15
Katherine Y H Chen, Nicole Messina, Susie Germano, Rhian Bonnici, Bridget Freyne, Michael Cheung, Greta Goldsmith, Tobias R Kollmann, Michael Levin, David Burgner, Nigel Curtis
The pathogenesis of Kawasaki disease (KD) remains unknown and there is accumulating evidence for the importance of the innate immune system in initiating and mediating the host inflammatory response. We compared innate immune responses in KD and toxic shock syndrome (TSS) participants more than two years after their acute illness with control participants to investigate differences in their immune phenotype. Toxic shock syndrome shares many clinical features with KD; by including both disease groups we endeavoured to explore changes in innate immune responses following acute inflammatory illnesses more broadly...
2018: PloS One
https://www.readbyqxmd.com/read/29447133/computerised-training-improves-cognitive-performance-in-chronic-pain-a-participant-blinded-randomised-active-controlled-trial-with-remote-supervision
#16
Katharine S Baker, Nellie Georgiou-Karistianis, Amit Lampit, Michael Valenzuela, Stephen J Gibson, Melita J Giummarra
Chronic pain is associated with reduced efficiency of cognitive performance, and few studies have investigated methods of remediation. We trialled a computerised cognitive training protocol to determine whether it could attenuate cognitive difficulties in a chronic pain sample. Thirty-nine adults with chronic pain (mean age = 43.3, 61.5% females) were randomised to an 8-week online course (3 sessions/week from home) of game-like cognitive training exercises, or an active control involving watching documentary videos...
January 11, 2018: Pain
https://www.readbyqxmd.com/read/29446971/preserved-neural-event-segmentation-in-healthy-older-adults
#17
Christopher A Kurby, Jeffrey M Zacks
An important feature of action understanding is that comprehenders segment the perceptual stream into events. Event segmentation dynamically engages a network of brain regions that likely play a role in how events are encoded. Here, in a sample of older adults, we assessed the relationship between changes in brain dynamics during movie watching and event understanding performance. Forty healthy older adults and a comparison sample of 12 younger adults passively viewed short movies of everyday activities while their brain activity was measured with fMRI...
February 15, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29446966/when-divided-attention-fails-to-enhance-memory-encoding-the-attentional-boost-effect-is-eliminated-in-young-old-adults
#18
Giulia Bechi Gabrielli, Pietro Spataro, Lina Pezzuti, Clelia Rossi-Arnaud
In the Attentional Boost Effect (ABE), images or words presented with to-be-responded target squares are later recognized more accurately than images or words presented with to-be-ignored distractor squares. Surprisingly, previous studies investigating the ABE have always examined young participants: thus, the question of whether this memory facilitation can be also observed in older adults has never been tested. The present study sought to fill this gap by examining whether healthy aging modulated the size of the ABE in 4 experiments in which the nature of the background stimuli (images vs...
February 15, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29446452/development-of-children-s-use-of-external-reminders-for-hard-to-remember-intentions
#19
Jonathan Redshaw, Johanna Vandersee, Adam Bulley, Sam J Gilbert
This study explored under what conditions young children would set reminders to aid their memory for delayed intentions. A computerized task requiring participants to carry out delayed intentions under varying levels of cognitive load was presented to 63 children (aged between 6.9 and 13.0 years old). Children of all ages demonstrated metacognitive predictions of their performance that were congruent with task difficulty. Only older children, however, set more reminders when they expected their future memory performance to be poorer...
February 15, 2018: Child Development
https://www.readbyqxmd.com/read/29445429/classification-of-mri-and-psychological-testing-data-based-on-support-vector-machine
#20
Wenlu Yang, Xinyun Chen, David S Cohen, Eric R Rosin, Arthur W Toga, Paul M Thompson, Xudong Huang
Alzheimer's disease (AD) is a progressive, and often fatal, brain disease that causes neurodegeneration, resulting in memory loss as well as other cognitive and behavioral problems. Here, we propose a novel multimodal method combining independent components from MRI measures and clinical assessments to distinguish Alzheimer's patients or mild cognitive impairment (MCI) subjects from healthy elderly controls. 70 AD subjects (mean age: 77.15 ± 6.2 years), 98 MCI subjects (mean age: 76.91 ± 5.7 years), and 150 HC subjects (mean age: 75...
December 2017: International Journal of Clinical and Experimental Medicine
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