keyword
MENU ▼
Read by QxMD icon Read
search

Ageing memory

keyword
https://www.readbyqxmd.com/read/28822725/berberine-modulates-amyloid-%C3%AE-peptide-generation-by-activating-amp-activated-protein-kinase
#1
Haijing Zhang, Chunhui Zhao, Guoqiong Cao, Limin Guo, Shuai Zhang, Yuexia Liang, Chunxia Qin, Ping Su, Hang Li, Wensheng Zhang
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory deficits and cognitive decline. Excessive amyloid-β (Aβ) peptide aggregates and forms soluble oligomers and insoluble cerebral amyloid plaques, which is widely thought to be the underlying pathogenic mechanism of AD. Therefore, effective regulation of Aβ metabolism is an important aspect of preventing and improving AD. Berberine, which is the main active component of the traditional medicinal herb Coptidis rhizoma, has a positive effect on reducing Aβ levels...
August 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28822693/whisker-dependent-responsiveness-of-c57bl-6j-to-different-behavioral-test-paradigms
#2
Seenu Haridas, Ramya Ganapathi, Mayank Kumar, Kailash Manda
Whisker trimming is very common in C57BL/6J mice. Dewhiskering may lead to an alteration in the thalamocortical connectivity and relevant behavioral functions. Since C57BL/6J is a commonly used strain for neurobehavioral studies, it is important to examine how whisker dependent heterogeneity affects the internal validity of behavioral phenotypes. The present study aimed to investigate the responsiveness of mice to different behavioral test paradigms in the presence or absence of whiskers. We employed two models of whisker deprivation: Acute Whisker Desensitization (AWD) and Chronic Habitual Dewhiskering (CHD)...
August 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28822221/brain-plasticity-cognitive-functions-and-neural-stem-cells-a-pivotal-role-for-the-brain-specific-neural-master-gene-srgap2-fam72
#3
Nguyen Thi Thanh Ho, Arne Kutzner, Klaus Heese
Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating protein 2 - family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity...
August 28, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28821958/midlife-work-related-stress-is-associated-with-late-life-cognition
#4
Shireen Sindi, Ingemar Kåreholt, Alina Solomon, Babak Hooshmand, Hilkka Soininen, Miia Kivipelto
To investigate the associations between midlife work-related stress and late-life cognition in individuals without dementia from the general population. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study population (n = 2000) was randomly selected from independent Finnish population-based surveys (baseline mean age 50 years). Participants underwent two re-examinations in late life (mean age 71 and 78 years, respectively). 1511 subjects participated in at least one re-examination (mean total follow-up 25 years)...
August 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28821661/attenuated-activity-across-multiple-cell-types-and-reduced-monosynaptic-connectivity-in-the-aged-perirhinal-cortex
#5
A P Maurer, S N Burke, K Diba, C A Barnes
The perirhinal cortex (PER), which is critical for associative memory and stimulus discrimination, has been described as a wall of inhibition between the neocortex and hippocampus. With advanced age, rats show deficits on PER-dependent behavioral tasks and fewer PER principal neurons are activated by stimuli, but the role of PER interneurons in these altered circuit properties in old age has not been characterized. In the present study, PER neurons were recorded while rats traversed a circular track bi-directionally in which the track was either empty or contained 8 novel objects evenly spaced around the track...
August 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821233/latent-class-analysis-of-multimorbidity-patterns-and-associated-outcomes-in-spanish-older-adults-a-prospective-cohort-study
#6
Beatriz Olaya, Maria Victoria Moneta, Francisco Félix Caballero, Stefanos Tyrovolas, Ivet Bayes, José Luis Ayuso-Mateos, Josep Maria Haro
BACKGROUND: This study sought to identify multimorbidity patterns and determine the association between these latent classes with several outcomes, including health, functioning, disability, quality of life and use of services, at baseline and after 3 years of follow-up. METHODS: We analyzed data from a representative Spanish cohort of 3541 non-institutionalized people aged 50 years old and over. Measures were taken at baseline and after 3 years of follow-up. Latent Class Analysis (LCA) was conducted using eleven common chronic conditions...
August 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28819993/lactobacillus-helveticus-fermented-milk-containing-lactononadecapeptide-nippltqtpvvvppflqpe-improves-cognitive-function-in-healthy-middle-aged-adults-a-randomised-double-blind-placebo-controlled-trial
#7
Kazuhito Ohsawa, Fumiya Nakamura, Naoto Uchida, Seiichi Mizuno, Hidehiko Yokogoshi
This study aimed to determine the effects of a Lactobacillus helveticus-fermented milk drink containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) on the cognitive function of healthy middle-aged adults. A randomised, double-blind controlled study was conducted in healthy participants who were randomly assigned to receive a L. helveticus-fermented milk drink (190 g/day) or the equivalent amount of a placebo drink once a day for eight weeks. Cognitive function was evaluated using the Japanese version of the repeatable battery for the assessment of neuropsychological status (RBANS) test...
August 18, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28818766/design-synthesis-and-in%C3%A2-vivo-study-of-novel-pyrrolidine-based-11%C3%AE-hsd1-inhibitors-for-age-related-cognitive-dysfunction
#8
Rosana Leiva, Christian Griñan-Ferré, Constantí Seira, Elena Valverde, Andrew McBride, Margaret Binnie, Belén Pérez, F Javier Luque, Mercè Pallàs, Axel Bidon-Chanal, Scott P Webster, Santiago Vázquez
Recent findings suggest that treatment with 11β-HSD1 inhibitors provides a novel approach to deal with age-related cognitive dysfunctions, including Alzheimer's disease. In this work we report potent 11β-HSD1 inhibitors featuring unexplored pyrrolidine-based polycyclic substituents. A selected candidate administered to 12-month-old SAMP8 mice for four weeks prevented memory deficits and displayed a neuroprotective action. This is the first time that 11β-HSD1 inhibitors have been studied in this broadly-used mouse model of accelerated senescence and late-onset Alzheimer's disease...
August 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28817118/altered-marginal-zone-and-innate-like-b-cells-in-aged-senescence-accelerated-samp8-mice-with-defective-igg1-responses
#9
Isabel Cortegano, Mercedes Rodríguez, Isabel Martín, Maria Carmen Prado, Carolina Ruíz, Rafael Hortigüela, Mario Alía, Marçal Vilar, Helena Mira, Eva Cano, Mercedes Domínguez, Belén de Andrés, María Luisa Gaspar
Aging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of marginal zone B lymphocytes (MZ, CD19(+)CD45R(+)CD21(++)CD23(lo)) and a decrease of naive B cells (CD19(+)IgD(+)), whereas there is an enhancement of a CD19(+)CD45R(lo) innate-like B cell population (B1REL) and the so-called aged B cell compartment (ABC, CD45R(+)CD21(lo)CD23(lo)CD5(-)CD11b(-)) in aged senescence-accelerated (SAMP8) mice but not in aged senescence-resistant (SAMR1) mice...
August 17, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28816627/transfiguring-desire-divining-the-origin-of-species
#10
Sonny Nordmarken, Samuel Ace
In this piece, we combine autoethnographic and poetic methods/genres to examine intimate and social experiences we have had as two transmasculine queers with complex sexual and gender histories in an intergenerational relationship. If queerness/transness is a "species," our title, playing on Darwin, promises an answer to oft-asked problematic questions of queer/trans origins. Refusing to address this question, we instead turn Darwin on himself and examine intimate moments in our lives to show how we have experienced the constant formation and personal evolution of desire and identity...
August 17, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28816475/the-role-of-stimulus-complexity-and-salience-in-memory-for-face-name-associations-in-healthy-adults-friend-or-foe
#11
Andrew R Bender, Moshe Naveh-Benjamin, Katheryn Amann, Naftali Raz
The associative deficit hypothesis (ADH) posits that age-related differences in recognition of associations are disproportionately larger than age differences in item recognition because of age-related difficulty in binding and retrieval of two or more pieces of information in a memory episode. This proposition rests on the observation of disproportionately greater age differences in memory for associations than in recognition of individual items. Although ADH has been supported in experiments with verbal and nonverbal stimuli, the effects of task or stimulus characteristics on its generalizability remain unclear...
August 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28816474/deficits-in-category-learning-in-older-adults-rule-based-versus-clustering-accounts
#12
Stephen P Badham, Adam N Sanborn, Elizabeth A Maylor
Memory research has long been one of the key areas of investigation for cognitive aging researchers but only in the last decade or so has categorization been used to understand age differences in cognition. Categorization tasks focus more heavily on the grouping and organization of items in memory, and often on the process of learning relationships through trial and error. Categorization studies allow researchers to more accurately characterize age differences in cognition: whether older adults show declines in the way in which they represent categories with simple rules or declines in representing categories by similarity to past examples...
August 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28814979/executive-functioning-in-cornelia-de-lange-syndrome-domain-asynchrony-and-age-related-performance
#13
Donna Reid, Jo Moss, Lisa Nelson, Laura Groves, Chris Oliver
BACKGROUND: The aim of this study was to examine executive functioning in adolescents and adults with Cornelia de Lange syndrome (CdLS) to identify a syndrome and age-related profile of cognitive impairment. METHODS: Participants were 24 individuals with CdLS aged 13-42 years (M = 22; SD = 8.98), and a comparable contrast group of 21 individuals with Down syndrome (DS) aged 15-33 years (M = 24; SD = 5.82). Measures were selected to test verbal and visual fluency, inhibition, perseverance/flexibility, and working memory and comprised both questionnaire and performance tests...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28814843/effects-of-hearing-loss-on-speech-recognition-under-distracting-conditions-and-working-memory-in-the-elderly
#14
Wondo Na, Gibbeum Kim, Gungu Kim, Woojae Han, Jinsook Kim
PURPOSE: The current study aimed to evaluate hearing-related changes in terms of speech-in-noise processing, fast-rate speech processing, and working memory; and to identify which of these three factors is significantly affected by age-related hearing loss. METHODS: One hundred subjects aged 65-84 years participated in the study. They were classified into four groups ranging from normal hearing to moderate-to-severe hearing loss. All the participants were tested for speech perception in quiet and noisy conditions and for speech perception with time alteration in quiet conditions...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28814669/neonatal-and-adult-recent-thymic-emigrants-produce-il-8-and-express-complement-receptors-cr1-and-cr2
#15
Marcin L Pekalski, Arcadio Rubio García, Ricardo C Ferreira, Daniel B Rainbow, Deborah J Smyth, Meghavi Mashar, Jane Brady, Natalia Savinykh, Xaquin Castro Dopico, Sumiyya Mahmood, Simon Duley, Helen E Stevens, Neil M Walker, Antony J Cutler, Frank Waldron-Lynch, David B Dunger, Claire Shannon-Lowe, Alasdair J Coles, Joanne L Jones, Chris Wallace, John A Todd, Linda S Wicker
The maintenance of peripheral naive T lymphocytes in humans is dependent on their homeostatic division, not continuing emigration from the thymus, which undergoes involution with age. However, postthymic maintenance of naive T cells is still poorly understood. Previously we reported that recent thymic emigrants (RTEs) are contained in CD31+CD25- naive T cells as defined by their levels of signal joint T cell receptor rearrangement excision circles (sjTRECs). Here, by differential gene expression analysis followed by protein expression and functional studies, we define that the naive T cells having divided the least since thymic emigration express complement receptors (CR1 and CR2) known to bind complement C3b- and C3d-decorated microbial products and, following activation, produce IL-8 (CXCL8), a major chemoattractant for neutrophils in bacterial defense...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814473/breaking-boundaries-optimizing-reconsolidation-based-interventions-for-strong-and-old-memories
#16
James W B Elsey, Merel Kindt
Recent research has demonstrated that consolidated memories can enter a temporary labile state after reactivation, requiring restabilization in order to persist. This process, known as reconsolidation, potentially allows for the modification and disruption of memory. Much interest in reconsolidation stems from the possibility that maladaptive memory traces-a core feature of several psychiatric conditions-could be tackled by disrupting their reconsolidation. However, research has indicated a range of supposed boundary conditions on the induction of reconsolidation...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814150/nitrous-oxide-labor-analgesia-and-pain-relief-memory-in-breastfeeding-women
#17
Vincenzo Zanardo, Francesca Volpe, Matteo Parotto, Lara Giiberti, Alessia Selmin, Gianluca Straface
OBJECTIVE: The use of labor pain relief medications is a controversial issue that has engendered heated discussions among health care professionals about safety, interference with birthing, and breastfeeding. METHODS: This is a case-control study with 62 puerperae treated with nitrous oxide and 124 control women (ratio 1:2), matched for age, gestational age, parity, delivery route, labor augmentation, and spinal regional analgesia. We tested anhedonia, anxiety, and depression symptoms at hospital discharge by The Edinburgh Postnatal Depression Scale (EPDS), and the intensity of nitrous oxide labor pain relief and satisfaction memory by a retrospective Visual Analog Scale (VAS, 0-10 Numeric Rating Scale) at a set cut off time of 3 months of a child's age...
August 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28812424/remember-some-or-remember-all-ageing-and-strategy-effects-in-visual-working-memory
#18
Amy L Atkinson, Alan D Baddeley, Richard J Allen
Recent research (Bengson & Luck, 2015) has indicated that visual working memory capacity for unidimensional items might be boosted by focusing on all presented items, as opposed to a subset of them. However, it is not clear whether the same outcomes would be observed if more complex items were used which require feature binding, a potentially more demanding task. The current experiments therefore examined the effects of encoding strategy using multidimensional items in tasks that required feature binding. Effects were explored across a range of different age groups (Experiment 1) and task conditions (Experiment 2)...
August 16, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28811259/should-i-trust-you-learning-and-memory-of-social-interactions-in-dementia
#19
Stephanie Wong, Muireann Irish, Claire O'Callaghan, Fiona Kumfor, Greg Savage, John R Hodges, Olivier Piguet, Michael Hornberger
Social relevance has an enhancing effect on learning and subsequent memory retrieval. The ability to learn from and remember social interactions may impact on susceptibility to financial exploitation, which is elevated in individuals with dementia. The current study aimed to investigate learning and memory of social interactions, the relationship between performance and financial vulnerability and the neural substrates underpinning performance in 14 Alzheimer's disease (AD) and 20 behavioural-variant frontotemporal dementia (bvFTD) patients and 20 age-matched healthy controls...
August 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28810929/the-impact-of-age-and-gut-microbiota-on-th17-and-tfh-cells-in-k-bxn-autoimmune-arthritis
#20
Fei Teng, Krysta M Felix, C Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A Raslan, Hsin-Jung Joyce Wu
BACKGROUND: Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood. Gut microbiota are known to be involved in the pathogenesis of RA, but the effects of microbiota in older subjects remain mostly unknown. METHODS: We used segmented filamentous bacteria (SFB), a gut commensal species with immunomodulatory effects, and K/BxN mice, a T cell receptor (TCR) transgenic model, to study the effect of age and microbiota on autoimmune arthritis...
August 15, 2017: Arthritis Research & Therapy
keyword
keyword
42351
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"