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Uric acid wound

Xiyuan Liu, Peter B Lillehoj
Electrochemical sensors are an attractive platform for analytical measurements due to their high sensitivity, portability and fast response time. These attributes also make electrochemical sensors well suited for wearable applications which require excellent flexibility and durability. Towards this end, we have developed a robust electrochemical sensor on gauze via a unique embroidery fabrication process for quantitative measurements of wound biomarkers. For proof of principle, this biosensor was used to detect uric acid, a biomarker for wound severity and healing, in simulated wound fluid which exhibits high specificity, good linearly from 0 to 800µM, and excellent reproducibility...
June 28, 2017: Biosensors & Bioelectronics
Andre Baumann, Marisa Skaljac, Rüdiger Lehmann, Andreas Vilcinskas, Zdenӗk Franta
Lucilia sericata maggots are the only species currently approved for maggot debridement therapy (MDT), an alternative treatment for chronic and recalcitrant wounds. Maggots promote wound debridement, disinfection and healing by producing a complex mixture of proteins, peptides and low-molecular-weight compounds in their secretions and excretions, but the individual components are not well characterized at the molecular level. Here we investigated the purine catabolism pathway in L. sericata, focusing on the production of allantoin by Urate Oxidase (UO), which is thought to promote wound healing...
April 2017: Insect Biochemistry and Molecular Biology
Quan Hong, Shandong Yu, Xiaodong Geng, Liping Duan, Wei Zheng, Men Fan, Xiangmei Chen, Di Wu
BACKGROUND: Whether microRNAs participate in endothelial dysfunction HUA remains unknown. A previous study indicated that miR-663 was the most significantly differentially expressed endothelial microRNA under HUA conditions. Some studies have demonstrated that the miR-663 target gene and TGF-β1, promoted endothelial cell migration by inhibiting PTEN deleted on chromosome 10. Therefore, we hypothesized that HUA inhibits endothelial migration via miR-663, which regulates PTEN by targeting TGF-β1...
May 2015: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Michael B Dreifke, Amil A Jayasuriya, Ambalangodage C Jayasuriya
In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting microRNA, and stem cell therapy...
March 2015: Materials Science & Engineering. C, Materials for Biological Applications
Melissa L Fernandez, Zee Upton, Gary K Shooter
Chronic wounds are an important health problem because they are difficult to heal and treatment is often complicated, lengthy and expensive. For a majority of sufferers the most common outcomes are long-term immobility, infection and prolonged hospitalisation. There is therefore an urgent need for effective therapeutics that will enhance ulcer healing and patient quality of life, and will reduce healthcare costs. Studies in our laboratory have revealed elevated levels of purine catabolites in wound fluid from patients with venous leg ulcers...
February 2014: Current Rheumatology Reports
Basavaraj S Nagoba, Ajay Punpale, Ashok Poddar, Namdev M Suryawanshi, Ganesh A Swami, Sohan P Selkar
The ulceration associated with gout tophi is very difficult to treat because of impaired and halted local inflammatory response resulting from the gout treatment regimen. We report chronic nonhealing tophaceous gout with bursitis in an 80-year-old male, not responding to conventional treatment modality for months together. This nonhealing ulcer was treated successfully with local application of 3% citric acid ointment for 22 days.
December 2013: International Journal of Lower Extremity Wounds
Duncan Sharp
New technologies are essential for intelligent wound management and to provide tools that facilitate a greater understanding of wounds and healing physiology. pH is an important marker for many processes in the wound environment; it cannot be fully utilised due to the inherent lack of suitable technologies currently available. The development and proof-of-concept testing for an electrochemical system that exploits pad-printed carbon-uric acid composite electrodes is detailed. Uric acid is incorporated to act as a biologically-safe pH probe within in the sensor assembly that can be manipulated to offer a simple voltammetric response...
December 15, 2013: Biosensors & Bioelectronics
Su-Shin Lee, Meng-Chum Chen, Yun-Hui Chou, Sin-Daw Lin, Chung-Sheng Lai, Ying-Cheng Chen
OBJECTIVES: Gouty arthritis results from the deposition of monosodium urate crystals in synovial spaces. The literature shows that a tophus may require surgical treatment to improve cosmesis or function, to alleviate pain, to eradicate sinus drainage or to remove large urate deposits. However, forceful curettage to remove tophus particles embedded in the thin attenuated skin flap may compromise blood circulation and cause other complications. This series presents the experience of the authors in performing intra-lesion shaving during the surgical treatment of tophus patients...
August 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Weiwei Wang, Zhenlong Wu, Zhaolai Dai, Ying Yang, Junjun Wang, Guoyao Wu
Glycine is a major amino acid in mammals and other animals. It is synthesized from serine, threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the liver and kidneys. Under normal feeding conditions, glycine is not adequately synthesized in birds or in other animals, particularly in a diseased state. Glycine degradation occurs through three pathways: the glycine cleavage system (GCS), serine hydroxymethyltransferase, and conversion to glyoxylate by peroxisomal D-amino acid oxidase...
September 2013: Amino Acids
Osamu Kawamoto, Tomomi Michiue, Takaki Ishikawa, Hitoshi Maeda
Pericardial fluid (PCF) is a well-preserved cadaveric material in cases without structural damage. The present study investigated fundamental serum components of PCF, including total proteins (TP), albumin (Alb), urea nitrogen (UN), creatinine (Cr), uric acid (UA), glucose (Glu), sodium (Na), potassium (K), chloride (Cl), calcium (Ca) and magnesium (Mg) in PCF with regard to the postmortem and survival periods, and cause of death in serial medicolegal autopsy cases (n=288) with intact pericardial and cardiac structures within 48h postmortem...
January 10, 2013: Forensic Science International
N S Nagane, J V Ganu, V R Bhagwat, M Subramanium
Thermal injury is associated with biochemical changes. The present study was undertaken to investigate relation of oxidative free radical generation and related biochemical parameters in burn trauma. The specific aim was to compare the levels of serum lipid peroxide, Ceruloplasmin and Uric Acid in burn patients during treatment with Silver Sulfadiazine Cream and honey therapy. It is a single blind prospective controlled study involving comparison of biochemical changes after treatment with silver sulfadiazine and honey treatment in burn injury...
July 2004: Indian Journal of Clinical Biochemistry: IJCB
Melissa L Fernandez, Zee Upton, Helen Edwards, Kathleen Finlayson, Gary K Shooter
Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity...
April 2012: International Wound Journal
Feixu Pan, Qi Li, Xin Tang, Jing Xue, Jian Li
OBJECTIVE: To investigate the method and the effectiveness of a combination of the arthroscopic debridement and joint irrigation postoperatively for treating gouty arthritis of the knee. METHODS: Between August 2000 and November 2009, 41 patients with gouty arthritis of the knee were treated by arthroscopic debridement. All patients were males with an average age of 42 years (range, 21-71 years), including 8 incipient cases and 33 relapsed cases. The unilateral knees were involved in 36 cases, including 22 left knees and 14 right knees, and both in 5 cases...
August 2011: Chinese Journal of Reparative and Reconstructive Surgery
Dominiki Economidou, Dorothea Kapoukranidou, Chrysostomos Dimitriadis, Despina Xioufi, Afroditi Pantzaki, Eleftherios Anagnostou, Dimitrios Memmos
BACKGROUND: A common strategy for the prevention of intra-abdominal adhesions post-operatively has been the application of adhesion barriers into the peritoneal cavity. Side effects of these barriers are infection, abscesses and inadequate wound healing. There is no information about such a side effect of these materials on renal function. The aim of this study was to evaluate the effect of two different, commercially available polysaccharide-based anti-adhesive materials on renal function...
February 2011: Nephrology, Dialysis, Transplantation
Alejandro R Chade, Xiang-Yang Zhu, James D Krier, Kyra L Jordan, Stephen C Textor, Joseph P Grande, Amir Lerman, Lilach O Lerman
Tissue injury triggers reparative processes that often involve endothelial progenitor cells (EPCs) recruitment. We hypothesized that atherosclerotic renal artery stenosis (ARAS) activates homing signals that would be detectable in both the kidney and EPCs, and attenuated on renal repair using selective cell-based therapy. Pigs were treated with intrarenal autologous EPC after 6 weeks of ARAS. Four weeks later, expression of homing-related signals in EPC and kidney, single kidney function, microvascular (MV) density, and morphology were compared with untreated ARAS and normal control pigs (n = 7 each)...
June 2010: Stem Cells
Srinivasulu Chigurupati, Mohamed R Mughal, Sic L Chan, Thiruma V Arumugam, Akanksha Baharani, Sung-Chun Tang, Qian-Sheng Yu, Harold W Holloway, Ross Wheeler, Suresh Poosala, Nigel H Greig, Mark P Mattson
Wound healing is a complex process involving intrinsic dermal and epidermal cells, and infiltrating macrophages and leukocytes. Excessive oxidative stress and associated inflammatory processes can impair wound healing, and antioxidants have been reported to improve wound healing in animal models and human subjects. Uric acid (UA) is an efficient free radical scavenger, but has a very low solubility and poor tissue penetrability. We recently developed novel UA analogs with increased solubility and excellent free radical-scavenging properties and demonstrated their ability to protect neural cells against oxidative damage...
April 6, 2010: PloS One
Gui-Sen Li, Xiu-Ling Chen, Yuan Zhang, Qiang He, Fang Wang, Da-Qing Hong, Ping Zhang, Lei Pu, Yue Zhang, Xiu-Chuan Yang, Li Wang
BACKGROUND: Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) remains unclear. This study describes the clinical characteristics of malnutrition and inflammation in patients with AKI and CS due to the Wenchuan earthquake. METHODS: One thousand and twelve victims and eighteen healthy adults were recruited to the study...
2010: BMC Nephrology
Jacob A Sloane, Daina Blitz, Zachary Margolin, Timothy Vartanian
Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes extensively to neurologic injury. With more recent focus on innate immune processes, it appears that necrotic, but not apoptotic, death mechanisms provoke inflammatory responses likely due to the release or production of endogenous ligands that activate resident immune cells of the central nervous system. These ligands comprise a diverse set of proteins, nucleic acids, and glycosaminoglycans, including heat shock proteins, HMGB1, RNA, DNA, hyaluronan, and heparin sulfate, that stimulate innate immune mechanisms largely through Toll-like receptors (TLRs)...
June 2010: Neuromolecular Medicine
V Naidoo, K Wolter, R Cuthbert, N Duncan
Veterinary diclofenac has been responsible for the devastation of three species of Gyps vulture on the Indian subcontinent, and it is now regarded as one of the worst environmental contaminants in the recent past. While measures have been taken to control the manufacture of veterinary diclofenac in South Asia, the promotion of diclofenac on the African continent poses a risk to vultures in this region. In Southern Africa, the species of greatest conservation concern is the Cape Griffon Vulture (Gyps coprotheres), as only 2900 breeding pairs remain in the wild...
April 2009: Regulatory Toxicology and Pharmacology: RTP
Duncan Sharp, Stephen Forsythe, James Davis
The applicability of employing a carbon fibre mesh as an electrochemical sensing substructure for assessing urate transformations within wound exudates is evaluated. Prototype sensor assemblies have been designed and their response characteristics towards uric acid and other common physiological components are detailed. Modification of the carbon fibre sensor through surface anodization and the application of cellulose acetate permselective barriers have been shown to lead to optimized responses and much greater sensitivity (1440% increase) and specificity...
July 2008: Journal of Biochemistry
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