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ductal in situ carcinoma

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https://www.readbyqxmd.com/read/29328775/breast-specimen-processing-and-reporting-with-an-emphasis-on-margin-evaluation
#1
Anthony J Guidi, Joseph A Tworek, Daniel D Mais, Rhona J Souers, Barbara J Blond, Richard W Brown
CONTEXT: The College of American Pathologists (CAP) developed protocols for reporting pathologic characteristics of breast cancer specimens, including margin status. The Society of Surgical Oncology (SSO) and the American Society for Radiation Oncology (ASTRO) published treatment guidelines regarding margins in patients with invasive cancer; and SSO, ASTRO, and the American Society of Clinical Oncology (ASCO) recently published guidelines for patients with ductal carcinoma in situ. OBJECTIVE: - To assess current practices among pathologists with regard to the processing/reporting of breast specimens, assess compliance with CAP cancer protocols, and assess alignment with SSO/ASTRO and SSO/ASTRO/ASCO guidelines...
January 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29325859/ki-67-expression-as-a-factor-predicting-recurrence-of-ductal-carcinoma-in-situ-of-the-breast-a-systematic-review-and-meta-analysis
#2
Nikiforita Poulakaki, Georgios-Marios Makris, Aristea-Maria Papanota, Filio Marineli, Alexandros Marinelis, Marco-Johannes Battista, Daniel Boehm, Amanda Psyrri, Theodoros N Sergentanis
BACKGROUND: Ki-67 is a marker of proliferating cells; in this meta-analysis we aimed to examine whether Ki-67 expression can predict recurrence rates of breast ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible articles were sought in MEDLINE up to April 30, 2017. Random effects (DerSimonian-Laird) models were used for the calculation of pooled relative risk (RR) estimates; meta-regression analysis was also performed...
December 16, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29323551/gamma-imaging-guided-minimally-invasive-breast-biopsy-initial-clinical-experience
#3
Rachel F Brem, Anita K Mehta, Jocelyn A Rapelyea, Esma A Akin, Adriana M Bazoberry, Christel D Velasco
OBJECTIVE: The purpose of this study was to evaluate our initial experience with gamma imaging-guided vacuum-assisted breast biopsy in women with abnormal findings. MATERIALS AND METHODS: A retrospective review of patients undergoing breast-specific gamma imaging (BSGI), also known as molecular breast imaging (MBI), between April 2011 and October 2015 found 117 nonpalpable mammographically and sonographically occult lesions for which gamma imaging-guided biopsies were recommended...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29322827/hypofractionated-volumetric-modulated-arc-therapy-in-ductal-carcinoma-in-situ-toxicity-and-cosmetic-outcome-from-a-prospective-series
#4
Fiorenza De Rose, Antonella Fogliata, Davide Franceschini, Cristina Iftode, Rosalba Torrisi, Giovanna Masci, Andrea Sagona, Corrado Tinterri, Alberto Testori, Wolfgang Gatzemeier, Bethania Fernandes, Daoud Rahal, Luca Cozzi, Armando Santoro, Marta Scorsetti
OBJECTIVE: Hypofractionated radiotherapy in early stage breast cancer is an effective adjuvant treatment, but there is a lack of randomized data for patients with ductal carcinoma in situ (DCIS). Aim of this study is the evaluation of skin toxicity and cosmesis, and early clinical outcome of DCIS patients enrolled in an institutional phase II trial of hypofractionated breast irradiation. METHODS: One hundred thirty-seven DCIS patients were enrolled in the trial...
January 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29317040/molecular-breast-imaging-a-comprehensive-review
#5
Ashley I Huppe, Anita K Mehta, Rachel F Brem
Molecular breast imaging (MBI), also called breast-specific gamma imaging (BSGI), has been an integral component of our breast imaging practice for over a decade. Unlike mammography and ultrasound that are based on anatomy, MBI is a physiologic approach to breast cancer detection. MBI detects additional foci of occult breast cancer in 9.0% of women with newly diagnosed breast cancer, has a high sensitivity for detecting high-risk lesions, and detects 98% of invasive breast cancer and 91.0% of ductal carcinoma in situ...
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#6
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29295986/macrophages-orchestrate-breast-cancer-early-dissemination-and-metastasis
#7
Nina Linde, Maria Casanova-Acebes, Maria Soledad Sosa, Arthur Mortha, Adeeb Rahman, Eduardo Farias, Kathryn Harper, Ethan Tardio, Ivan Reyes Torres, Joan Jones, John Condeelis, Miriam Merad, Julio A Aguirre-Ghiso
Cancer cell dissemination during very early stages of breast cancer proceeds through poorly understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a previously described sub-population of early-evolved cancer cells requires macrophages for early dissemination. Depletion of macrophages specifically during pre-malignant stages reduces early dissemination and also results in reduced metastatic burden at end stages of cancer progression. Mechanistically, we show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+ macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+ early cancer cells...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29285517/context-aware-stacked-convolutional-neural-networks-for-classification-of-breast-carcinomas-in-whole-slide-histopathology-images
#8
Babak Ehteshami Bejnordi, Guido Zuidhof, Maschenka Balkenhol, Meyke Hermsen, Peter Bult, Bram van Ginneken, Nico Karssemeijer, Geert Litjens, Jeroen van der Laak
Currently, histopathological tissue examination by a pathologist represents the gold standard for breast lesion diagnostics. Automated classification of histopathological whole-slide images (WSIs) is challenging owing to the wide range of appearances of benign lesions and the visual similarity of ductal carcinoma in-situ (DCIS) to invasive lesions at the cellular level. Consequently, analysis of tissue at high resolutions with a large contextual area is necessary. We present context-aware stacked convolutional neural networks (CNN) for classification of breast WSIs into normal/benign, DCIS, and invasive ductal carcinoma (IDC)...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29285046/the-practice-patterns-and-perceptions-of-korean-surgeons-regarding-margin-status-after-breast-conserving-surgery
#9
Tae-Kyung Yoo, Sung-Won Kim, Eunyoung Kang, Sung Gwe Ahn, Ki-Tae Hwang, Seung-Ki Kim, Sang Uk Woo, Hyuk Jai Shin, Young-Jin Song, Eun-Jung Jung, Myung-Chul Chang, Ilkyun Lee, Woo-Chan Park
Two consecutive surveys for breast surgeons in Korea were conducted to comprehend the practice patterns and perceptions on margin status after breast-conserving surgery. The surveys were conducted online in 2014 (initial) and 2016 (follow-up). A total of 126 and 88 responses were obtained in the initial and follow-up survey, respectively. More than 80% of the respondents replied to routinely apply frozen section biopsy for intraoperative margin assessment in both surveys. Re-excision recommendations of the margin for invasive cancer significantly changed from a close margin to a positive margin over time (p=0...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29285036/selective-radiation-therapy-for-ductal-carcinoma-in-situ-following-breast-conserving-surgery-according-to-age-and-margin-width-korean-radiation-oncology-group-11-04-and-16-02-studies
#10
Kyubo Kim, Jin Hee Kim, Yong Bae Kim, Chang-Ok Suh, Kyung Hwan Shin, Jin Ho Kim, Tae Hyun Kim, So-Youn Jung, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Ji Woon Yea, Min Kyu Kang, Dong Won Kim, Yi-Jun Kim
Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of <1 cm, both of which have been proven to be high-risk features for recurrence in cohorts not receiving RT. Methods: Using two multicenter retrospective studies on DCIS, a pooled analysis was performed among patients aged ≤50 years and with margin widths <1 cm...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29282034/outcome-of-breast-cancer-screening-in-denmark
#11
Elsebeth Lynge, Martin Bak, My von Euler-Chelpin, Niels Kroman, Anders Lernevall, Nikolaj Borg Mogensen, Walter Schwartz, Adam Jan Wronecki, Ilse Vejborg
BACKGROUND: In Denmark, national roll-out of a population-based, screening mammography program took place in 2007-2010. We report on outcome of the first four biennial invitation rounds. METHODS: Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29273956/interventions-are-needed-to-support-patient-provider-decision-making-for-dcis-a-scoping-review
#12
REVIEW
Claire Kim, Laurel Liang, Frances C Wright, Nicole J Look Hong, Gary Groot, Lucy Helyer, Pamela Meiers, May Lynn Quan, Robin Urquhart, Rebecca Warburton, Anna R Gagliardi
PURPOSE: Prognostic and treatment uncertainty make ductal carcinoma in situ (DCIS) complex to manage. The purpose of this study was to describe research that evaluated DCIS communication experiences, needs and interventions among DCIS patients or physicians. METHODS: MEDLINE, EMBASE, CINAHL and The Cochrane Library were searched from inception to February 2017. English language studies that evaluated patient or physician DCIS needs, experiences or behavioural interventions were eligible...
December 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29273054/significant-suppression-of-radiation-dermatitis-in-breast-cancer-patients-using-a-topically-applied-adrenergic-vasoconstrictor
#13
James F Cleary, Bethany M Anderson, Jens C Eickhoff, Deepak Khuntia, William E Fahl
BACKGROUND: Our previous studies showed that vasoconstrictor applied topically to rat skin minutes before irradiation completely prevented radiodermatitis. Here we report on a Phase IIa study of topically applied NG12-1 vasoconstrictor to prevent radiodermatitis in post-lumpectomy breast cancer patients who received at least 40 Gray to the whole breast using standard regimens. METHODS: Patients had undergone surgery for Stage Ia, Ib, or IIa infiltrating ductal or lobular carcinoma of the breast or ductal carcinoma in situ...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29246496/mirnas-as-biomarkers-for-predicting-the-progression-of-ductal-carcinoma-in-situ
#14
REVIEW
Bethany N Hannafon, Wei-Qun Ding
Ductal carcinoma in situ (DCIS) is defined as a proliferation of neoplastic cells within the duct of the mammary gland that have not invaded into the surrounding stroma. DCIS is considered a precursor to invasive ductal carcinoma (IDC); however, approximately half of DCIS may progress to IDC, if left untreated. Current research has shown that the genomic and transcriptomic changes are present in DCIS before the emergence of invasive disease, indicating that the malignant nature of the DCIS is defined before invasion...
December 12, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29243740/will-oncotype-dx-dcis-testing-guide-therapy-a-single-institution-correlation-of-oncotype-dx-dcis-results-with-histopathologic-findings-and-clinical-management-decisions
#15
Chieh-Yu Lin, Kelly Mooney, Winward Choy, Soo-Ryum Yang, Keegan Barry-Holson, Kathleen Horst, Irene Wapnir, Kimberly Allison
Given the increased detection rates of ductal carcinoma in situ (DCIS) and the limited overall survival benefit from adjuvant breast irradiation after breast-conserving surgery, there is interest in identifying subsets of patients who have low rates of ipsilateral breast tumor recurrence such that they might safely forgo radiation. The Oncotype DCIS score is a reverse transcription-PCR (RT-PCR)-based assay that was validated to predict which DCIS cases are most likely to recur. Clinically, these results may be used to assist in selecting which patients with DCIS might safely forgo radiation therapy after breast-conserving surgery; however, little is currently published on how this test is being used in practice...
December 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29239733/breast-conserving-surgery-for-extensive-dcis-using-multiple-radioactive-seeds
#16
N N Y Janssen, R F D van la Parra, C E Loo, E J Groen, M J van den Berg, H S A Oldenburg, J Nijkamp, M T F D Vrancken Peeters
BACKGROUND AND OBJECTIVES: Breast conserving surgery (BCS) can be challenging for large regions of ductal carcinoma in situ (DCIS), resulting in high rates of positive resection margins. Radioactive seed localization (RSL) using multiple radioactive iodine (125I) seeds can be used to bracket extensive DCIS (eDCIS). The goal of this study was to retrospectively compare the use of a single or multiple 125I seeds in RSL to enable BCS in patients with eDCIS. METHODS: All patients with eDCIS (area of ≥3...
November 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29231050/follow-up-interval-for-probably-benign-breast-lesions-on-screening-ultrasound-in-women-at-average-risk-for-breast-cancer-with-dense-breasts
#17
Hee Jung Moon, Min Jung Kim, Jung Hyun Yoon, Eun-Kyung Kim
Background Women at high risk for breast cancer and women at average risk have different pretest probabilities. Probably benign lesions on screening ultrasound (US) should be assessed and managed differently for these two risk groups. Purpose To evaluate the effectiveness of short-term follow-up for probably benign lesions on screening US in women at average risk for breast cancer with dense breasts. Material and Methods A total of 445 women at average risk for breast cancer with probably benign lesions on screening US, dense breasts, and negative or benign mammography results were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29230131/body-art-confounding-a-case-of-breast-cancer
#18
Lena Gowharji, Dana Smetherman, Brett Roberts
Background: Heavy metals in tattoo ink can be deposited in axillary lymph nodes, mimicking malignant calcifications. High-density foci in axillary lymph nodes can be the sequelae of a benign or malignant process. Case Report: A 34-year-old female presented with left breast discomfort. Mammography showed suspicious left breast calcifications for which biopsy revealed multicentric ductal carcinoma in situ. Imaging also showed high-density foci in her left axillary lymph nodes suspicious for nodal metastases; however, biopsy of the lymph nodes found the high-density foci to be pigment-laden histiocytes from tattoo ink metallic deposits...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29230119/a-potential-additional-variable-to-consider-in-the-surgical-treatment-of-ductal-carcinoma-in-situ
#19
Katherine Chaisson, Amy Rivere, Ralph Corsetti, Tova Weiss, George M Fuhrman
Background: HER2/neu is a potentially interesting variable that has been demonstrated to have a profound impact on the management of invasive breast carcinoma, and we performed this study to evaluate the differences between HER2-positive and HER2-negative ductal carcinoma in situ. The impetus for this study was our poor recruitment to the National Surgical Adjuvant Breast and Bowel Project Protocol B-43 trial that was designed to evaluate the potential role of trastuzumab in breast conservation therapy for patients with HER2-positive ductal carcinoma in situ...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29224275/-clinicopathologic-study-of-infiltrating-epitheliosis-of-the-breast
#20
X L Xu, X Y Tu, R H Shui, Y F Cheng, B H Yu, W T Yang
Objective: To evaluate the morphological and immunohistochemical features of infiltrating epitheliosis and its differential diagnosis. Methods: Nine consultation and routine cases of infiltrating epitheliosis diagnosed from January 2015 to December 2016 in Fudan University Shanghai Cancer Center were collected. All tissues were formalin-fixed paraffin-embedded and routinely HE stained. The HE slides were reviewed. Immunohistochemical staining of CKpan, CK7, CK19, CK5/6, CK14, p63, SMMHC, Calponin, ER, PR, HER2, Ki-67 and S-100 protein was performed using Ventana BenchMark automated immunostainer...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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