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ductal in situ carcinoma

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https://www.readbyqxmd.com/read/29786772/upstaging-to-invasive-ductal-carcinoma-after-mastectomy-for-ductal-carcinoma-in-situ-predictive-factors-and-role-of-sentinel-lymph-node-biopsy
#1
Yusuke Watanabe, Keisei Anan, Michiyo Saimura, Kenichiro Koga, Minoru Fujino, Mari Mine, Sadafumi Tamiya, Kazuyoshi Nishihara, Toru Nakano, Shoshu Mitsuyama
BACKGROUND: The aim of this study was to investigate preoperative factors associated with ductal carcinoma in situ (DCIS) upstaged to invasive ductal carcinoma (IDC) and sentinel lymph node (SLN) status in patients who underwent mastectomy for a preoperative diagnosis of DCIS. METHODS: The medical records of 220 patients who underwent mastectomy for a preoperative diagnosis of DCIS were retrospectively reviewed. RESULTS: Fifty-one (22.6%) of 226 lesions were upgraded to IDC after mastectomy...
May 21, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29786482/human-epidermal-growth-factor-2-positive-breast-cancer-with-mammographic-microcalcification-relationship-to-pathologic-complete-response-after-neoadjuvant-chemotherapy
#2
Fayyaz A K Mazari, Nisha Sharma, David Dodwell, Kieran Horgan
Purpose To determine the relationship between the presence or absence of mammographic calcifications in human epidermal growth factor receptor 2 (HER2)-positive breast cancers and pathologic complete response (pCR) to neoadjuvant chemotherapy and to determine other tumor and clinical characteristics that may be predictive of such a response. Materials and Methods A database of all patients with HER2-positive breast cancer who underwent neoadjuvant chemotherapy between 2007 and 2015 was retrospectively reviewed...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29777742/a-functional-glycoproteomics-approach-identifies-cd13-as-a-novel-e-selectin-ligand-in-breast-cancer
#3
M A Carrascal, M Silva, J A Ferreira, R Azevedo, D Ferreira, A M N Silva, D Ligeiro, L L Santos, R Sackstein, P A Videira
BACKGROUND: The glycan moieties sialyl-Lewis-X and/or -A (sLeX/A ) are the primary ligands for E-selectin, regulating subsequent tumor cell extravasation into distant organs. However, the nature of the glycoprotein scaffolds displaying these glycans in breast cancer remains unclear and constitutes the focus of the present investigation. METHODS: We isolated glycoproteins that bind E-selectin from the CF1_T breast cancer cell line, derived from a patient with ductal carcinoma...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29773535/should-patients-with-ductal-carcinoma-in-situ-be-treated-with-adjuvant-whole-breast-radiotherapy-after-breast-conservation-surgery
#4
Jessamy Bagenal, Nicola Roche, Gill Ross, Anna Kirby, David Dodwell
No abstract text is available yet for this article.
May 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29764880/digital-breast-tomosynthesis-plus-synthesised-images-versus-standard-full-field-digital-mammography-in-population-based-screening-tosyma-protocol-of-a-randomised-controlled-trial
#5
Stefanie Weigel, Joachim Gerss, Hans-Werner Hense, Miriam Krischke, Alexander Sommer, Jörg Czwoydzinski, Horst Lenzen, Laura Kerschke, Karin Spieker, Stefanie Dickmaenken, Sonja Baier, Marc Urban, Gerold Hecht, Oliver Heidinger, Joachim Kieschke, Walter Heindel
INTRODUCTION: Development of digital breast tomosynthesis (DBT) provides a technology that generates three-dimensional data sets, thus reducing the pitfalls of overlapping breast tissue. Observational studies suggest that the combination of two-dimensional (2D) digital mammography and DBT increases diagnostic accuracy. However, because of duplicate exposure, this comes at the cost of an augmented radiation dose. This undesired adverse impact can be avoided by using synthesised 2D images reconstructed from the DBT data (s2D)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29763991/factors-influencing-reoperation-following-breast-conserving-surgery
#6
Andrew Philpott, Joshua Wong, Kenneth Elder, Alexandra Gorelik, G Bruce Mann, Anita Skandarajah
BACKGROUND: Reoperation rates after breast-conserving surgery are highly variable and the best techniques for optimizing margin clearance are being evaluated. The aim was to identify the reoperation rate at our centre and identify influential factors, including a change in guidelines on margin recommendations and the introduction of in-theatre specimen X-ray. METHODS: A retrospective review of medical records was undertaken to identify 562 patients who underwent breast conservation at The Royal Melbourne Hospital and Royal Women's Hospital between 2013 and 2015...
May 15, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29759643/oncoplastic-breast-surgery-for-the-management-of-ductal-carcinoma-in-situ-dcis-is-it-oncologically-safe-a-retrospective-cohort-analysis
#7
Francesca De Lorenzi, Julien Di Bella, Patrick Maisonneuve, Nicole Rotmensz, Giovanni Corso, Roberto Orecchia, Marco Colleoni, Giovanni Mazzarol, Mario Rietjens, Pietro Loschi, Stefano Marcelli, Paolo Veronesi, Viviana Galimberti
BACKGROUND: Few data exist in literature regarding oncoplastic surgery (ONC) and ductal carcinoma in situ (DCIS). The role of ONC in the treatment of DCIS has not been elucidated yet: no case-control study has yet been published on the issue and no long-term oncologic results are reported. METHODS: Using the European Institute of Oncology (IEO) institutional breast cancer data base we investigated the oncologic safety of ONC for DCIS comparing a consecutive series of 44 patients who have underwent ONC followed by external irradiation for DCIS (Group A-study group) with 375 patients who received conservation alone followed by external irradiation for DCIS (Group B control group) in the same period...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29758996/patterns-of-malignant-non-mass-enhancement-on-3-t-breast-mri-help-predict-invasiveness-using-the-bi-rads-lexicon-fifth-edition
#8
Seung Min Lee, Kyung Jin Nam, Ki Seok Choo, Jin You Kim, Dong Wook Jeong, Hyun Yul Kim, Jee Yeon Kim
Background Non-mass enhancements (NME) with invasive components account for 10-42% of total malignant NMEs. The factors associated with invasiveness on magnetic resonance imaging (MRI) could be useful for clinical assessment and treatment. Purpose To evaluate the clinical significances of the distributions and internal enhancement patterns (IEP) of malignant NMEs on 3-T breast MRI. Material and Methods A total of 448 consecutive women with newly diagnosed breast cancer that had undergone preoperative MRI and surgery between February 2013 and March 2016 were identified...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29756510/oncoplastic-breast-conserving-surgery-in-iceland-a-population-based-study
#9
E P Palsdottir, S H L Lund, K S A Asgeirsson
BACKGROUND AND AIMS: In Iceland, oncoplastic breast-conservation surgery has been performed since 2008. The aim of this population-based study was to assess and compare the efficacy and patient satisfaction of standard breast-conservation surgery with oncoplastic breast-conservation surgery. MATERIALS AND METHODS: This is a population-based, retrospective, observational cohort study on all women undergoing breast-conservation surgery in Iceland from the 1 January 2008 to 31 December 2014...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29753007/evaluating-agreement-histological-features-and-relevance-of-separating-pleomorphic-and-florid-lobular-carcinoma-in-situ-subtypes
#10
Kamaljeet Singh, Cherie Paquette, Elizabeth T Kalife, Yihong Wang, Shamlal Mangray, M Ruhul Quddus Md MPhil, Margaret M Steinhoff
Morphological variants of lobular carcinoma in situ (LCIS) include classical- (CLCIS), pleomorphic- (PLCIS) and florid-type (FLCIS). Treatment guidelines suggest managing PLCIS and FLCIS like ductal carcinoma in situ (DCIS); therefore accurate identification of LCIS subtypes is critical. However significance of separating PLCIS from FLCIS is not clear. Also inter-observer agreement in identifying LCIS subtypes, using contemporary criteria, is not known. We aimed to evaluate inter-observer agreement amongst breast pathologists in diagnosing LCIS subtypes and use the agreement data to justify LCIS classification for management purposes...
May 9, 2018: Human Pathology
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#11
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29731404/tumor-resection-margin-definitions-in-breast-conserving-surgery-systematic-review-and-meta-analysis-of-the-current-literature
#12
REVIEW
Susan G Brouwer de Koning, Marie-Jeanne T F D Vrancken Peeters, Katarzyna Jóźwiak, Patrick A Bhairosing, Theo J M Ruers
Worldwide, various guidelines recommend what constitutes an adequate margin of excision for invasive breast cancer or for ductal carcinoma-in-situ (DCIS). We evaluated the use of different tumor resection margin guidelines and investigated their impact on positive margin rates (PMR) and reoperation rates (RR). Thirteen guidelines reporting on the extent of a positive margin were reviewed along with 31 studies, published between 2011 and 2016, reporting on a well-defined PMR. Studies were categorized according to the margin definition...
April 13, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29731165/encapsulated-papillary-carcinoma-of-the-breast-a-clinicopathological-study-of-49-cases
#13
Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu
BACKGROUND: Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ. Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. METHODS: Forty-nine EPC patients admitted to the Tai'an Central Hospital and Qilu Hospital of Shandong University from January 2004-December 2014 were included in this study...
March 30, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29730730/risk-of-ischemic-heart-disease-after-radiotherapy-for-ductal-carcinoma-in-situ
#14
C Wadsten, A-K Wennstig, H Garmo, Greger Nilsson, Carl Blomqvist, Lars Holmberg, Irma Fredriksson, F Wärnberg, M Sund
PURPOSE: The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of women with DCIS. METHODS: The Breast Cancer DataBase Sweden (BCBase) cohort includes women registered with invasive and in situ breast cancers 1992-2012 and age-matched women without a history of breast cancer...
May 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29730304/assessing-the-effectiveness-of-interventions-to-support-patient-decision-making-about-breast-reconstruction-a-systematic-review
#15
REVIEW
Nicole Paraskeva, Ella Guest, Helena Lewis-Smith, Diana Harcourt
BACKGROUND: Decision making about breast reconstruction (BR) following a diagnosis of breast cancer, Ductal Carcinoma in Situ (DCIS), or to reduce future breast cancer risk, is difficult and complex. This paper systematically reviews interventions aiming to support patients facing the option of BR, and assesses their effectiveness in improving a range of patient outcomes. METHODS: Ten databases were searched for articles published up to October 2017 that evaluated interventions to support patient decision making about BR within controlled trials...
May 3, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29720211/atypical-ductal-hyperplasia-update-on-diagnosis-management-and-molecular-landscape
#16
REVIEW
Tanjina Kader, Prue Hill, Emad A Rakha, Ian G Campbell, Kylie L Gorringe
BACKGROUND: Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma upon excision; however, the remainder of patients are overtreated. While ADH is considered a non-obligate precursor of invasive carcinoma, the molecular taxonomy remains unknown. MAIN TEXT: Although a few studies have revealed some of the key genomic characteristics of ADH, a clear understanding of the molecular changes associated with breast cancer progression has been limited by inadequately powered studies and low resolution methodology...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29719444/ductal-carcinoma-in-situ-is-presumably-not-a-metastatic-disease-a-reply-to-commentary-wherein-the-authors-attempt-to-minimize-the-confusion-generated-by-their-study-breast-cancer-mortality-after-a-diagnosis-of-ductal-carcinoma-in-situ-by-several-commentators
#17
https://www.readbyqxmd.com/read/29719429/prescribing-practices-of-endocrine-therapy-for-ductal-carcinoma-in-situ-in-british-columbia
#18
A T Chaudhry, T A Koulis, C Speers, R A Olson
Purpose: The mainstay of treatment for ductal carcinoma in situ (dcis) involves surgery in the form of mastectomy or lumpectomy. Inconsistency in the use of endocrine therapy (et) for dcis is evident worldwide. We sought to assess the variation in et prescribing for patients with dcis across a population-based radiotherapy (rt) program and to identify variables that predict its use. Methods: Data from a breast cancer database were obtained for women diagnosed with dcis in British Columbia from 2009 to 2014...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29718790/cumulative-risk-distribution-for-interval-invasive-second-breast-cancers-after-negative-surveillance-mammography
#19
Janie M Lee, Linn Abraham, Diana L Lam, Diana S M Buist, Karla Kerlikowske, Diana L Miglioretti, Nehmat Houssami, Constance D Lehman, Louise M Henderson, Rebecca A Hubbard
Purpose The aim of the current study was to characterize the risk of interval invasive second breast cancers within 5 years of primary breast cancer treatment. Methods We examined 65,084 surveillance mammograms from 18,366 women with a primary breast cancer diagnosis of unilateral ductal carcinoma in situ or stage I to III invasive breast carcinoma performed from 1996 to 2012 in the Breast Cancer Surveillance Consortium. Interval invasive breast cancer was defined as ipsilateral or contralateral cancer diagnosed within 1 year after a negative surveillance mammogram...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29717421/treatment-intensity-differences-after-early-stage-breast-cancer-esbc-diagnosis-depending-on-participation-in-a-screening-program
#20
Kenneth Elder, Carolyn Nickson, Melinda Pattanasri, Samuel Cooke, Dorothy Machalek, Allison Rose, Arlene Mou, John Paxton Collins, Allan Park, Richard De Boer, Claire Phillips, Vicki Pridmore, Helen Farrugia, G Bruce Mann
BACKGROUND: While population mammographic screening identifies early-stage breast cancers (ESBCs; ductal carcinoma in situ [DCIS] and invasive disease stages 1-3A), commentaries suggest that harms from overdiagnosis and overtreatment may outweigh the benefits. Apparent benefits to patients with screen-detected cancers may be due to selection bias from exclusion of interval cancers (ICs). Treatment intensity is rarely discussed, with an assumption that all ESBCs are treated similarly. We hypothesized that women diagnosed while in a screening program would receive less-intense treatment than those never or not recently screened (NRS)...
May 1, 2018: Annals of Surgical Oncology
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