Julia Borges Paes Lemes, Kaue Franco Malange, Nathalia Santos Carvalho, Amanda Ferreira Neves, Marcia Urban-Maldonado, Paula Regina Gelinski Kempe, Catarine Massucato Nishijima, Cecilia Costa Fagundes, Celina Monteiro da Cruz Lotufo, Sylvia Ottile Suadicani, Carlos Amilcar Parada
BACKGROUND: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation. At the central nervous system, the role of Panx1 is already well-established. However, in the periphery, there is a lack of information regarding the participation of Panx1 in neuronal sensitization. The dorsal root ganglion (DRG) is a critical structure for pain processing and modulation. For this reason, understanding the molecular mechanism in the DRG associated with neuronal hypersensitivity has become highly relevant to discovering new possibilities for pain treatment...
March 20, 2024: Journal of Integrative Neuroscience