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Conditioned pain modulation

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https://www.readbyqxmd.com/read/29451889/effects-of-patterned-peripheral-nerve-stimulation-on-soleus-spinal-motor-neuron-excitability
#1
Samuel Jimenez, Laura Mordillo-Mateos, Michele Dileone, Michela Campolo, Carmen Carrasco-Lopez, Fabricia Moitinho-Ferreira, Tomas Gallego-Izquierdo, Hartwig R Siebner, Josep Valls-Solé, Juan Aguilar, Antonio Oliviero
Spinal plasticity is thought to contribute to sensorimotor recovery of limb function in several neurological disorders and can be experimentally induced in animals and humans using different stimulation protocols. In healthy individuals, electrical continuous Theta Burst Stimulation (TBS) of the median nerve has been shown to change spinal motoneuron excitability in the cervical spinal cord as indexed by a change in mean H-reflex amplitude in the flexor carpi radialis muscle. It is unknown whether continuous TBS of a peripheral nerve can also shift motoneuron excitability in the lower limb...
2018: PloS One
https://www.readbyqxmd.com/read/29445338/synaptic-homeostasis-and-allostasis-in-the-dentate-gyrus-caused-by-inflammatory-and-neuropathic-pain-conditions
#2
Rui-Rui Wang, Yan Wang, Su-Min Guan, Zhen Li, Saurabh Kokane, Fa-Le Cao, Wei Sun, Chun-Li Li, Ting He, Yan Yang, Qing Lin, Jun Chen
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitatory and inhibitory synaptic transmission and modulation of the dentate gyrus (DG) under two pain conditions with different etiology and duration. First, it was revealed that the functions of the input-output (I/O) curves for evoked excitatory postsynaptic currents (eEPSCs) following the perforant path (PP) stimulation were gained under both acute inflammatory and chronic neuropathic pain conditions relative to the controls...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29438845/-brain-over-body-a-study-on-the-willful-regulation-of-autonomic-function-during-cold-exposure
#3
Otto Muzik, Kaice T Reilly, Vaibhav A Diwadkar
The defense of body temperature against environmental thermal challenges is a core objective of homeostatic regulation governed by the autonomic nervous system. Autonomous mechanisms of thermoregulation are only weakly affected by top-down modulation, allowing only transient tolerance for extreme cold. There is however, anecdotal evidence of a unique set of individuals known for extreme cold tolerance. Here we present a case study of a 57-year old Dutch national, Wim Hof, the so-called "Iceman", with the ability to withstand frequent prolonged periods of extreme cold exposure based on the practice of a self-developed technique involving a combination of forced breathing, cold exposure and meditation (collectively referred to as the Wim Hof Method, henceforth "WHM")...
February 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29412789/long-term-treatment-by-mesenchymal-stem-cells-conditioned-medium-modulates-cellular-molecular-and-behavioral-aspects-of-adjuvant-induced-arthritis
#4
Vida Nazemian, Homa Manaheji, Ali Mohammad Sharifi, Jalal Zaringhalam
Neuroinflammation plays a crucial role in expression of symptoms of numerous autoimmune and neurodegenerative diseases such as pain during rheumatoid arthritis. Overproduction of pro-inflammatory cytokines and activation of intracellular signaling pathways have been strongly implicated in the generation of pathological pain states, particularly at central nervous system sites and induction of spinal neuroinflammatory symptoms. The wide ranges of research to define new therapeutic approaches, including neuroimmune-modulators like stem cells are in progress...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29409632/predictors-of-disability-and-absenteeism-in-workers-with-non-specific-low-back-pain-a-longitudinal-15-month-study
#5
Arnaud Lardon, Jean-Daniel Dubois, Vincent Cantin, Mathieu Piché, Martin Descarreaux
OBJECTIVES: The objective of this study was to identify baseline predictors of disability and absenteeism in workers with a history of non-specific low back pain (LBP). METHODS: One hundred workers with a history of non-specific LBP participated in three evaluations (baseline, 7 and 15 months follow-up). Current and past history of LBP, clinical pain intensity, disability, absenteeism, fear-avoidance beliefs, pain catastrophizing, pain hypervigilance, work satisfaction and patient stratification based on "risk of poor clinical outcome assessment" (RPCO) were evaluated using questionnaires and interviews...
April 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29401595/thy1-is-a-positive-regulator-of-osteoblast-differentiation-and-modulates-bone-homeostasis-in-obese-mice
#6
Ananta Paine, Collynn F Woeller, Hengwei Zhang, Maria de la Luz Garcia-Hernandez, Nelson Huertas, Lianping Xing, Richard P Phipps, Christopher T Ritchlin
Thy1 (CD90), a glycosylated, glycophosphatidylinositol-anchored membrane protein highly expressed by subsets of mesenchymal stem cells and fibroblasts, inhibits adipogenesis. The role of Thy1 on bone structure and function has been poorly studied and represents a major knowledge gap. Therefore, we analyzed the long bones of wild-type (WT) and Thy1 knockout (KO) mice with micro-computed tomography (CT) and histomorphometry to compare changes in bone architecture and overall bone structure. micro-CT analysis of long bones revealed Thy1 KO and WT mice fed a high-fat diet demonstrated bone structural parameters at 4 mo that differed significantly between WT and KO mice...
January 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29392240/a-tonic-heat-test-stimulus-yields-a-larger-and-more-reliable-conditioned-pain-modulation-effect-compared-to-a-phasic-heat-test-stimulus
#7
Marie Udnesseter Lie, Dagfinn Matre, Per Hansson, Audun Stubhaug, John-Anker Zwart, Kristian Bernhard Nilsen
Introduction: The interest in conditioned pain modulation (CPM) as a clinical tool for measuring endogenously induced analgesia is increasing. There is, however, large variation in the CPM methodology, hindering comparison of results across studies. Research comparing different CPM protocols is needed in order to obtain a standardized test paradigm. Objectives: The aim of the study was to assess whether a protocol with phasic heat stimuli as test-stimulus is preferable to a protocol with tonic heat stimulus as test-stimulus...
November 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29392208/efficient-conditioned-pain-modulation-despite-pain-persistence-in-painful-diabetic-neuropathy
#8
Yelena Granovsky, Hadas Nahman-Averbuch, Mogher Khamaisi, Michal Granot
Introduction: Alleviation of pain, by either medical or surgical therapy, is accompanied by transition from less efficient, or pro-nociceptive, to efficient conditioned pain modulation (CPM). Spontaneous decrease or resolution of pain with disease progression is reported for some patients with painful diabetic neuropathy (PDN). Objectives: To explore whether CPM changes similarly in parallel to spontaneous resolution of pain in PDN patients. Methods: In this cross-sectional study, thirty-three patients with PDN underwent psychophysical assessment of pain modulation on the forearm, remote from the clinical pain...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29391829/the-potential-role-of-angiogenesis-in-the-development-of-shoulder-pain-shoulder-dysfunction-and-lymphedema-after-breast-cancer-treatment
#9
REVIEW
Trevor S Mafu, Alison V September, Delva Shamley
Shoulder morbidity is a well-documented sequela of breast cancer treatment, which includes various manifestations such as pain, reduced range of motion, and lymphedema, among others. The multifactorial nature of such morbidities has long been appreciated, and research on reliable risk predictors of development thereof still continues. Previous studies have demonstrated the potential of different types of physical therapy to treat such shoulder problems, and the integration of such interventions into routine care for breast cancer survivors is a requirement in most high-income countries...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29377353/blockade-of-dopamine-d2-receptors-disrupts-intrahippocampal-connectivity-and-enhances-pain-related-working-memory-deficits-in-neuropathic-pain-rats
#10
H Cardoso-Cruz, M Dourado, C Monteiro, V Galhardo
BACKGROUND: Dopamine (DA) is thought to be important to local hippocampal networks integrity during spatial working memory (sWM) processing. Chronic pain may contribute to deficient dopaminergic signalling, which may in turn affect cognition. However, the neural mechanisms that determine this impairment are poorly understood. Here, we evaluated whether the sWM impairment characteristic of animal models of chronic pain is dependent on DA D2 receptor (D2r) activity. METHODS: To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 field (dvCA1) of rats and recorded the neuronal activity during a classical delayed food-reinforced T-maze sWM task...
January 26, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29369967/lateralized-kappa-opioid-receptor-signaling-from-the-amygdala-central-nucleus-promotes-stress-induced-functional-pain
#11
Kelsey M Nation, Milena DeFelice, Pablo I Hernandez, David W Dodick, Volker Neugebauer, Edita Navratilova, Frank Porreca
The diffuse noxious inhibitory controls (DNIC) response is often decreased, or lost, in stress-related functional pain syndromes. As the dynorphin/kappa opioid receptor (KOR) pathway is activated by stress, we determined its role in DNIC using a model of stress-induced functional pain. Male, Sprague Dawley rats were primed for 7 days with systemic morphine resulting in opioid-induced hyperalgesia. Fourteen days after priming, when hyperalgesia was resolved, rats were exposed to environmental stress and DNIC was evaluated by measuring hindpaw response threshold to noxious pressure (test stimulus) following capsaicin injection in the forepaw (conditioning stimulus)...
January 23, 2018: Pain
https://www.readbyqxmd.com/read/29363387/association-between-abo-blood-types-and-pain-perception
#12
Amalie Højmose Simoni, Anne Jerwiarz, Amalie Randers, Parisa Gazerani
AIM OF THE STUDY: Pain perception is associated with different phenotypic characteristics such as sex, eye, and hair color. Hence, it is assumed that ABO blood type can also affect pain perception. MATERIALS AND METHODS: In order to investigate this hypothesis, an experimental study with healthy volunteers (18-40 years) was designed. The experimental procedure included a blood type test and two rounds of pressure pain threshold assessments separated by a cold pressor test...
January 24, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29360608/resting-functional-connectivity-of-the-periaqueductal-gray-is-associated-with-normal-inhibition-and-pathological-facilitation-in-conditioned-pain-modulation
#13
Daniel E Harper, Eric Ichesco, Andrew Schrepf, Johnson P Hampson, Daniel J Clauw, Tobias Schmidt-Wilcke, Richard E Harris, Steven E Harte
Conditioned pain modulation (CPM), a psychophysical paradigm that is commonly used to infer the integrity of endogenous pain-altering systems by observation of the effect of one noxious stimulus on another, has previously identified deficient endogenous analgesia in fibromyalgia (FM) and other chronic pain conditions. The mechanisms underlying this deficiency, be they insufficient inhibition and/or active facilitation, are largely unknown. The present cross sectional study used a combination of behavioral CPM testing, voxel based morphometry (VBM), and resting state functional connectivity to identify neural correlates of CPM in healthy controls (HC; n=14) and FM patients (n=15), and to probe for differences that could explain the pain-facilitative CPM that was observed in our patient sample...
January 19, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29357856/clinical-relevance-of-contextual-factors-as-triggers-of-placebo-and-nocebo-effects-in-musculoskeletal-pain
#14
Giacomo Rossettini, Elisa Carlino, Marco Testa
Placebo and nocebo effects are embodied psycho-neurobiological responses capable of modulating pain and producing changes at different neurobiological, body at perceptual and cognitive levels. These modifications are triggered by different contextual factors (CFs) presented in the therapeutic encounter between patient and healthcare providers, such as healing rituals and signs. The CFs directly impact on the quality of the therapeutic outcome: a positive context, that is a context characterized by the presence of positive CFs, can reduce pain by producing placebo effects, while a negative context, characterized by the presence of negative CFs, can aggravate pain by creating nocebo effects...
January 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29357488/roller-massage-decreases-spinal-excitability-to-the-soleus
#15
James Douglas Young, Alyssa-Joy Spence, David G Behm
Roller massage (RM) interventions have shown acute increases in range of motion (ROM) and pain pressure threshold (PPT). It is unclear whether the RM-induced increases can be attributed to changes in neural or muscle responses. The purpose of this study was to evaluate the effect of altered afferent input via application of RM on spinal excitability, as measured with the Hoffmann (H-) reflex. A randomized within-subjects design was used. Three 30-second bouts of RM were implemented on a rested, non-exercised, injury-free muscle with 30-seconds of rest between bouts...
January 4, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29348828/dose-escalation-by-image-guided-intensity-modulated-radiotherapy-leads-to-an-increase-in-pain-relief-for-spinal-metastases-a-comparison-study-with-a-regimen-of-30-gy-in-10-fractions
#16
Jinlan He, Jianghong Xiao, Xingchen Peng, Baofeng Duan, Yan Li, Ping Ai, Min Yao, Nianyong Chen
Purpose: Under the existing condition that the optimum radiotherapy regimen for spinal metastases is controversial, this study investigates the benefits of dose escalation by image-guided intensity-modulated radiotherapy (IG-IMRT) with 60-66 Gy in 20-30 fractions for spinal metastases. Results: In the dose-escalation group, each D50 of planning gross tumor volume (PGTV) was above 60 Gy and each Dmax of spinal cord planning organ at risk volume (PRV) was below 48 Gy...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29344989/salmon-calcitonin-ameliorates-migraine-pain-through-modulation-of-cgrp-release-and-dural-mast-cell-degranulation-in-rats
#17
Erkan Kilinc, Yasar Dagistan, Aysel Kukner, Bayram Yilmaz, Sami Agus, Gizem Soyler, Fatma Tore
The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this study, we explored the mechanisms underlying the analgesic effect of salmon calcitonin on migrane pain using glyceryltrinitrate(GTN)-induced model of migraine and ex-vivo meningeal preparations in rats. Rats were administered intraperitoneally saline, GTN(10mg/kg), vehicle, saline+GTN, SC(50μg/kg)+GTN, and SC alone...
January 18, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29343280/pregabalin-versus-placebo-in-targeting-pro-nociceptive-mechanisms-to-prevent-chronic-pain-after-whiplash-injury-in-at-risk-individuals-a-feasibility-study-for-a-randomised-controlled-trial
#18
J Nikles, G Keijzers, G Mitchell, S Schug, R Ware, S A McLean, L Connelly, S Gibson, S F Farrell, M Sterling
BACKGROUND: Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of central sensitization is associated with poor recovery. Pregabalin's effects on central sensitization indicate the potential to prevent or modulate these processes after whiplash injury and to improve health outcomes, but this has not been investigated...
January 17, 2018: Trials
https://www.readbyqxmd.com/read/29327392/differences-in-white-matter-structure-and-cortical-thickness-between-patients-with-traumatic-and-idiopathic-chronic-neck-pain-associations-with-cognition-and-pain-modulation
#19
I Coppieters, R De Pauw, K Caeyenberghs, D Lenoir, K DeBlaere, E Genbrugge, M Meeus, B Cagnie
Brain alterations are hypothesized to be present in patients with chronic whiplash-associated disorders (CWAD). The aim of this case-control study was to examine alterations in cortical thickness and white matter (WM) structure, and the presence of brain microhemorrhages in a patient group encountering chronic neck pain of traumatic origin (i.e., CWAD) when compared with a patient group characterized by nontraumatic chronic neck pain [i.e., chronic idiopathic neck pain (CINP)], and healthy controls. Furthermore, we aimed to investigate associations between brain structure on one hand and cognitive performance and central sensitization (CS) on the other hand...
January 11, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29325145/anxiety-dependent-modulation-of-motor-responses-to-pain-expectancy
#20
Carlotta Fossataro, Giulia Bucchioni, Federico D'Agata, Valentina Bruno, Rosalba Morese, Pierre Krystkowiak, Francesca Garbarini
The relationship between pain expectancy and motor system plays a crucial role in the human defensive system. Here, we took advantage of the inhibitory modulation of the motor pathway to the muscle of the hand receiving painful stimuli, by recording motor-evoked potentials (MEPs) to Transcranial Magnetic Stimulation (TMS). We employed a classical conditioning paradigm in which neutral (visual and auditory) stimuli were conditioned by pairing either painful or not-painful stimuli (electric shocks) in separated groups...
January 8, 2018: Social Cognitive and Affective Neuroscience
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