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Conditioned pain modulation

D Ayim-Aboagye, T Gordh
Aims Women show higher frequency of most painful disorders. This is usually explained that endogenous pain modulation pathways, which affect incoming nociceptive signals, act differently in women and men, but psycho-social factors are likelytoinfluence as well. Ghanaian women suffer different disabilities that may lead to severe pain. The hard climatic conditions and the hard physical toil in work exert untold injuries. How do women in Ghana cope with painful disorders, and do they show certain behavioural pattern during diagnosis and treatments? Methods The study used in-depth interviews with health care providers to accomplish its aim...
December 29, 2017: Scandinavian Journal of Pain
P W Stroman, G Ioachim, J M Powers, R Staud, C Pukall
Descending regulation of spinal cord responses to nociceptive signaling has a strong influence on pain perception. Prior studies using functional magnetic resonance imaging (fMRI) have indicated that in addition to reactive responses to nociceptive signals there is a continuous component to regulation, and that it may vary with differences in pain sensitivity. We hypothesize that this continuous regulation component occurs routinely in fMRI studies prior to noxious stimulation, as well as during, and following stimulation...
June 12, 2018: Pain
Ricardo Galhardoni, Daniel Ciampi de Andrade, Mariana Yt Puerta, Andre R Brunoni, Bruna Lr Varotto, José Tt de Siqueira, Manoel J Teixeira, Silvia Rdt Siqueira
Introduction Persistent idiopathic facial pain is a refractory and disabling condition of unknown mechanism and etiology. It has been suggested that persistent idiopathic facial pain patients have not only peripheral generators of pain, but also central nervous system changes that would contribute to the persistence of symptoms. We hypothesized that persistent idiopathic facial pain would have changes in brain cortical excitability as measured by transcranial magnetic stimulation compared to healthy controls...
January 1, 2018: Cephalalgia: An International Journal of Headache
Danica Bajic, Krisztina Monory, Andrea Conrad, Christina Maul, Roland M Schmid, Carsten T Wotjak, Christoph K Stein-Thoeringer
Endocannabinoids acting through cannabinoid receptor type 1 (CB1) are major modulators of peripheral somatic and visceral nociception. Although only partially studied, some evidence suggests a particular role of CB1 within the brain in nociceptive processes. As the endocannabinoid system regulates affect and emotional behaviors, we hypothesized that cerebral CB1 influences affective processing of visceral pain-related behaviors in laboratory animals. To study nocifensive responses modulated by supraspinal CB1, we used conditional knock-out mice lacking CB1 either in cortical glutamatergic neurons (Glu-CB1-KO), or in forebrain GABAergic neurons (GABA-CB1-KO), or in principle neurons of the forebrain (CaMK-CB1-KO)...
June 6, 2018: Neuroscience
Kati Thieme, Tina Meller, Ulrika Evermann, Robert Malinowski, Marc Mathys, Richard H Gracely, William Maixner, Dennis C Turk
AIM: An intrinsic pain regulatory system is modulated by both cardiovascular dynamics that influence baroreflex sensitivity (BRS) and diminished in Fibromyalgia (FM). Baroreceptors relay cardiovascular output to the dorsal medial nucleus tractus solitarius reflex arcs that regulate pain, sleep, anxiety, and blood pressure. This study evaluated the effects of Systolic Extinction Training (SET), which combines operant treatment (OT) with BaroReflexTraining (BRT). BRT delivers peripheral electrical stimulation within a few milliseconds of the systolic or diastolic peak of the cardiac cycle...
June 8, 2018: Arthritis Care & Research
M Karst
The endocannabinoid system (ECS) controls a large number of vital functions. Suboptimal tone of the ECS in certain regions of the nervous system may be associated with disorders that are also associated with pain. Pain and inflammation processes can be modulated by the exogenous supply of cannabinoids. Low-to-moderate pain-relieving effects and in individual cases large pain-relieving effects were observed in randomized, controlled studies of various types of chronic pain. People with chronic neuropathic pain and stress symptoms seem to particularly benefit...
June 7, 2018: Der Schmerz
Carlo Corona, Silvia Pasini, Jin Liu, Fatou Amar, Lloyd A Greene, Michael L Shelanski
Activating Transcription Factor 4 (ATF4) has been postulated as a key regulator of learning and memory. We previously reported that specific hippocampal ATF4 down-regulation causes deficits in synaptic plasticity and memory and reduction of glutamatergic functionality. Here we extend our studies to address ATF4's role in neuronal excitability. We find that long-term ATF4 knockdown in cultured rat hippocampal neurons significantly increases the frequency of spontaneous action potentials. This effect is associated with decreased functionality of metabotropic GABAB receptors (GABAB Rs)...
June 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Steven P Cohen, Anuj Bhatia, Asokumar Buvanendran, Eric S Schwenk, Ajay D Wasan, Robert W Hurley, Eugene R Viscusi, Samer Narouze, Fred N Davis, Elspeth C Ritchie, Timothy R Lubenow, William M Hooten
BACKGROUND: Over the past 2 decades, the use of intravenous ketamine infusions as a treatment for chronic pain has increased dramatically, with wide variation in patient selection, dosing, and monitoring. This has led to a chorus of calls from various sources for the development of consensus guidelines. METHODS: In November 2016, the charge for developing consensus guidelines was approved by the boards of directors of the American Society of Regional Anesthesia and Pain Medicine and, shortly thereafter, the American Academy of Pain Medicine...
June 7, 2018: Regional Anesthesia and Pain Medicine
P James B Dyck, Jennifer A Tracy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is probably the best recognized progressive immune-mediated peripheral neuropathy. It is characterized by a symmetrical, motor-predominant peripheral neuropathy that produces both distal and proximal weakness. Large-fiber abnormalities (weakness and ataxia) predominate, whereas small-fiber abnormalities (autonomic and pain) are less common. The pathophysiology of CIDP is inflammatory demyelination that manifests as slowed conduction velocities, temporal dispersion, and conduction block on nerve conduction studies and as segmental demyelination, onion-bulb formation, and endoneurial inflammatory infiltrates on nerve biopsies...
June 2018: Mayo Clinic Proceedings
M Tsukamoto, K K Petersen, C D Mørch, L Arendt-Nielsen
Aims Traditionally, conditioning pain modulation (CPM) can be assessed by applying a test stimulus (TS) before and after application of a conditioning stimulus (CS), which is normally applied extra-segmental. Currently, no studies have attempted to apply the TS and CS to the same site using different stimuli modalities. The aim of this study was to evaluate electrical TS and cuff pressure CS applied to the same experimental site for studying CPM. Methods 20 male volunteers participated in this study, which consisted of stimulations applied by a cuff-algometer (NociTech and Aalborg University, Denmark) and current stimulator (Digitimer DS5, UK), through two Ag/AgCl electrodes (Ambu® Neuroline 700, Denmark)...
December 29, 2017: Scandinavian Journal of Pain
M Duroux, H S H Vinterhøj, A Stensballe, P Gazerani
Aims Satellite glial cells (SGCs) are non-neuronal cells that entirely surround neurons within sensory ganglia. This unique structure allows SGC-neuron interactions. Altered cross-talk following nerve injury or inflammation is thought to contribute to pathogenesis of chronic pain. Release of extracellular vesicles in form of exosomes has been found to play a key role in cell-cell communication. However, release of exosomes from SGCs and their potential role in modulating pain remain unknown. Hence, this study aimed at identifying and characterizing shed exosomes from SGCs under normal and inflammatory conditions...
December 29, 2017: Scandinavian Journal of Pain
M Hoegh, K K Petersen, T Graven-Nielsen
Aims Conditioned pain modulation (CPM) is used to assess descending pain modulation through a test stimulation (TS) and a conditioning stimulation (CS). Due to potential carry-over effects, sequential CPM paradigms might alter the intensity of the CS, which potentially can alter the CPM-effect. This study aimed to investigate the difference between a fixed and adaptive CS intensity on CPM-effect. Methods On the dominant leg of 20 healthy subjects the cuff pressure detection threshold (PDT) was recorded as TS and the pain tolerance threshold (PTT) was assessed on the non-dominant leg for estimating the CS...
December 29, 2017: Scandinavian Journal of Pain
F A Jure, F G Arguissain, J A Biurrun Manresa, O K Andersen
Aims Conditioned pain modulation (CPM) is a paradigm employed to assess descending control of spinal nociception. Previous studies have shown that CPM affects the nociceptive withdrawal reflex (NWR) threshold (RTh), typically assessed in one muscle. However, the NWR activates not one but a group of synergistic muscles, which are recruited by common neural commands to achieve the limb withdrawal. In this regard, synergy analysis can provide the minimum coordinated recruitment of groups of muscles with specific activation balances that describe a movement...
December 29, 2017: Scandinavian Journal of Pain
Ryan Patel, Chaoling Qu, Jennifer Y Xie, Frank Porreca, Anthony H Dickenson
Pontine noradrenergic neurones form part of a descending inhibitory system that influences spinal nociceptive processing. Weak or absent descending inhibition is a common feature of chronic pain patients. We examined the extent to which the descending noradrenergic system is tonically active, how control of spinal neuronal excitability is integrated into thalamic relays within sensory-discriminative projection pathways, and how this inhibitory control is altered after nerve injury. In vivo electrophysiology was performed in anaesthetised spinal nerve ligated (SNL) and sham-operated rats to record from wide dynamic range neurones in the ventral posterolateral thalamus (VPL)...
May 31, 2018: Pain
Kristian Kjær Petersen, Hjalte Holm Andersen, Masato Tsukamoto, Lincoln Tracy, Julian Koenig, Lars Arendt-Nielsen
BACKGROUND AND AIMS: The autonomic nervous system (ANS) is capable of modulating pain. Aberrations in heart rate variability (HRV), reflective of ANS activity, are associated with experimental pain sensitivity, chronic pain, and more recently, pain modulatory mechanisms but the underlying mechanisms are still unclear. HRV is lowered during experimental pain as well as in chronic pain conditions and HRV can be increased by propranolol, which is a non-selective β-blocker. Sensitization of central pain pathways have been observed in several chronic pain conditions and human mechanistic pain biomarkers for these central pain pathways include temporal summation of pain (TSP) and conditioned pain modulation (CPM)...
June 2, 2018: Scandinavian Journal of Pain
Junad Khan, Olga Korczeniewska, Rafael Benoliel, Mythili Kalladka, Eli Eliav, Cibelle Nasri-Heir
OBJECTIVE: The aim of this study was to investigate intraoral temporal summation (TS) and conditioned pain modulation (CPM) and compare the outcome with TS and CPM induced in the forearm. In addition, we aimed to study the effect of age and gender on intraoral and forearm TS and CPM. STUDY DESIGN: Mechanical stimulation was induced with # 5.46 von Frey filament applying 26 grams of force. A single stimulus, followed by a train of 30 successive stimuli, was applied intraorally and to the dominant forearm...
April 13, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Kieran Rea, Fiona McGowan, Louise Corcoran, Michelle Roche, David P Finn
BACKGROUND AND PURPOSE: The emotional processing and coordination of top-down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the mPFC, (infralimbic (IL), prelimbic (PrL), anterior cingulate (ACC) cortices), differentially alter the expression of contextually-induced fear and nociceptive behaviour. We investigated the role of the endocannabinoid system in the IL, PrL and ACC in formalin-evoked nociceptive behaviour, fear-conditioned analgesia (FCA) and conditioned fear in the presence of nociceptive tone...
May 30, 2018: British Journal of Pharmacology
Keren Grinberg, Michal Granot, Lior Lowenstein, Liora Abramov, Irit Weissman-Fogel
OBJECTIVES: A patient's personal interpretations of a health threat or "illness perceptions" (IPs) are associated with their clinical outcomes. This study explored whether IPs are associated with pain severity and ability to modulate pain in women with chronic pelvic pain syndrome (CPPS), as well as the predictive value of IPs on Myofascial Physical Therapy (MPT) success. METHODS: Illness Perceptions Questionnaire - Revised (IPQ-R), mechanical and heat pain thresholds, mechanical temporal summation (mTS), and conditioned pain modulation (CPM) were evaluated in CPPS patients (n=39) before, and 3 months after MPT...
May 25, 2018: Clinical Journal of Pain
Sukhbir Kaur, William L Benton, Sirima A Tongkhuya, Cierra M C Lopez, Lynda Uphouse, Dayna L Averitt
Many persistent pain conditions occur predominantly in women making pain a major women's health issue. One theory for the prevalence in females is hormone modulation of pain mechanisms. The peripheral release of the neurotransmitter serotonin (5HT) has been implicated in various sexually dimorphic pain conditions; yet no studies have examined the effect of ovarian hormones on peripheral 5HT-evoked pain behaviors. We hypothesized that peripheral 5HT evokes greater pain behaviors in female rodents during estrus and/or proestrus, stages of the estrous cycle where ovarian hormones are greatly fluctuating...
May 23, 2018: Neuroscience
Marc I Rosen, William C Becker, Anne C Black, Steve Martino, Ellen L Edens, Robert D Kerns
Objective: High proportions of post-9/11 veterans have musculoskeletal disorders (MSDs), but engaging them in care early in their course of illness has been challenging. The service connection application is an ideal point of contact for referring veterans to early interventions for their conditions. Design: Among MSD claimants who reported risky substance use, we pilot-tested a counseling intervention targeting pain and risky substance use called Screening Brief Intervention and Referral to Treatment-Pain Module (SBIRT-PM)...
May 22, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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