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Conditioned pain modulation

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https://www.readbyqxmd.com/read/29649637/angiogenesis-impairment-by-the-nadph-oxidase-triggered-oxidative-stress-at-the-bone-implant-interface-critical-mechanisms-and-therapeutic-targets-for-implant-failure-under-hyperglycemic-conditions-in-diabetes
#1
Xiao-Fan Hu, Lin Wang, Geng Xiang, Wei Lei, Ya-Fei Feng
Mechanism underlying the diabetes-induced poor osteointegration of implants remains elusive, making it a challenge to develop corresponding solutions. Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant interface (BII) and the related mechanisms. In vivo, titanium screws were implanted in the femurs of mice, and, in vitro, vascular endothelial cell (VEC) was cultured on titanium surface. Results showed that, compared with normal milieu (NM), diabetic milieu (DM) led to angiogenesis inhibition around implants which resulted in reduced osteoprogenitors and poor bone formation on BII in vivo...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29649030/resistin-is-a-novel-marker-for-postoperative-pain-intensity
#2
Jun Hozumi, Masahiko Sumitani, Daisuke Nishizawa, Makoto Nagashima, Kazutaka Ikeda, Hiroaki Abe, Ryoji Kato, Yoshiomi Kusakabe, Yoshitsugu Yamada
BACKGROUND: Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, adiponectin, and resistin) and 2 nonspecific proinflammatory cytokines (tumor necrosis factor α and interleukin-6) with regard to their association with postoperative pain intensity. METHODS: We analyzed a total of 45 single-nucleotide polymorphisms of the adipokines in 57 patients with postlaparotomy pain...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29620559/unilateral-lateral-epicondylalgia-demonstrates-a-pro-nociceptive-pain-profile-a-case-control-observational-study
#3
Leanne Bisset, Michelle Carty, Ashley Smith
OBJECTIVE: Lateral epicondylalgia (LE, tennis elbow) is characterised by both local tissue pathology and features indicative of secondary hyperalgesia. The aim of this study was to evaluate endogenous pain modulation characteristics in people with chronic LE, and to investigate the relationship between endogenous pain modulation and clinical characteristics. METHODS: This case control observational study included 25 participants with LE of at least 6 weeks' duration and 15 age-matched (±5▒y) healthy control participants, who were each evaluated in a single session...
April 3, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29618132/systemic-exercise-induced-hypoalgesia-following-isometric-exercise-reduces-conditioned-pain-modulation
#4
Ali Alsouhibani, Henrik Bjarke Vaegter, Marie Hoeger Bement
Objective: Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This study investigated the effects of acute isometric exercise on CPM. In addition, the between-session and within-session reliability of CPM was investigated. Design: Experimental, randomized crossover study. Setting: Laboratory at Marquette University...
April 3, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29615860/endocannabinoid-system-and-migraine-pain-an-update
#5
REVIEW
Rosaria Greco, Chiara Demartini, Anna M Zanaboni, Daniele Piomelli, Cristina Tassorelli
The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, the endocannabinoid system (ES) has recently attracted considerable attention. Experimental and clinical data suggest indeed a link between dysregulation of this signaling complex and migraine headache...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29614835/botulinum-toxin-type-a-a-modulator-of-spinal-neuron-glia-interactions-under-neuropathic-pain-conditions
#6
REVIEW
Ewelina Rojewska, Anna Piotrowska, Katarzyna Popiolek-Barczyk, Joanna Mika
Neuropathic pain represents a significant clinical problem because it is a chronic condition often refractory to available therapy. Therefore, there is still a strong need for new analgesics. Botulinum neurotoxin A (BoNT/A) is used to treat a variety of clinical diseases associated with pain. Glia are in continuous bi-directional communication with neurons to direct the formation and refinement of synaptic connectivity. This review addresses the effects of BoNT/A on the relationship between glia and neurons under neuropathic pain...
April 2, 2018: Toxins
https://www.readbyqxmd.com/read/29607323/office-cycling-a-promising-way-to-raise-pain-thresholds-and-increase-metabolism-with-minimal-compromising-of-work-performance
#7
Rebecca Tronarp, André Nyberg, Mattias Hedlund, Charlotte K Häger, Suzanne McDonough, Martin Björklund
Aim: Establishing the effects of low intensity cycling (LC), moderate intensity cycling (MC), and standing at a simulated office workstation on pain modulation, work performance, and metabolic expenditure. Methods: 36 healthy adults (21 females), mean age 26.8 (SD 7.6) years, partook in this randomized 3 × 3 crossover trial with 75 minutes of LC on 20% of maximum aerobic power (MAP) output, 30 minutes of MC on 50% of MAP, and standing 30 minutes with 48-hour wash-out periods...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29597084/pain-adaptability-in-individuals-with-chronic-musculoskeletal-pain-is-not-associated-with-conditioned-pain-modulation
#8
Dawn Wong Lit Wan, Lars Arendt-Nielsen, Kelun Wang, Charlie Changli Xue, Yanyi Wang, Zhen Zheng
Healthy humans can be divided into the pain adaptive (PA) and the pain non-adaptive (PNA) groups; PA showed a greater decrease in pain rating to a cold pressor test (CPT) than PNA. This study examined if the dichotomy of pain adaptability existed in individuals with chronic musculoskeletal pain (MSK). CPTs at 2°C and 7°C were used to assess the status of pain adaptability in participants with either chronic non-specific low back pain or knee osteoarthritis. The participants' potency of conditioned pain modulation (CPM) and local inhibition were measured...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29597080/individual-variation-in-pain-sensitivity-and-conditioned-pain-modulation-in-acute-low-back-pain-impact-of-stimulus-type-sleep-psychological-and-lifestyle-factors
#9
David M Klyne, G Lorimer Moseley, Michele Sterling, Mary F Barbe, Paul W Hodges
Generalised hyperalgesia and impaired pain modulation are reported in chronic low back pain (LBP). Few studies have tested whether these features are present in the acute-phase. This study aimed to test for differences in pain presentation in early-acute LBP and evaluate the potential contribution of other factors to variation in sensitivity. Individuals within two weeks of onset of acute LBP (N=126) and pain-free controls (N=74) completed questionnaires related to their pain, disability, behaviour and psychological status before undergoing conditioned pain modulation (CPM) and pain threshold (heat, cold and pressure) testing at the back and forearm/thumb...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29593042/vzv-orf63-protects-human-neuronal-and-keratinocyte-cell-lines-from-apoptosis-and-changes-its-localization-upon-apoptosis-induction
#10
Chelsea Gerada, Megan Steain, Brian P McSharry, Barry Slobedman, Allison Abendroth
There are many facets of varicella zoster virus (VZV) pathogenesis that are not fully understood, such as the mechanisms involved in the establishment of lifelong latency, reactivation and development of serious conditions such as post herpetic neuralgia (PHN). Virus-encoded modulation of apoptosis has been suggested to play an important role in these processes. VZV open reading frame (ORF) 63 has been shown to modulate apoptosis in a cell type specific manner, but the impact of ORF63 on cell death pathways has not been examined in isolation, in the context of human cells...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29581063/characterization-of-rat-primary-trigeminal-satellite-glial-cells-and-associated-extracellular-vesicles-under-normal-and-inflammatory-conditions
#11
Hye Sook Han Vinterhøj, Allan Stensballe, Meg Duroux, Parisa Gazerani
Satellite glial cells (SGCs) in sensory ganglia contribute to the pathogenesis of chronic pain, potentially through mediating extracellular or paracrine signaling. Recently, extracellular vesicles (EVs) in the form of exosomes have been found to play an important role in cell-cell communication. However, their release from SGCs and extent in modulating pain remain unknown. An in vitro cell platform using fresh primary SGCs was used to characterize the shed vesicles by size and proteomic profiling following activation of SGCs by lipopolysaccharide (LPS), simulating neurogenic inflammation in vivo...
March 23, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29575996/soleus-h-reflex-and-its-modulation-with-vibration-in-idiopathic-toe-walkers-and-typically-developing-children
#12
Essi Marttinen Rossi, Päivi Nevalainen, Helena Mäenpää, Leena Lauronen
Idiopathic toe walking is a relatively common developmental condition often leading to secondary problems such as pain and muscle contractures in the lower extremities. The cause of idiopathic toe walking is unknown, which hinders the development of treatment strategies. To test whether children with idiopathic toe walking have functional alterations in their spinal motor circuits, we studied the properties of the soleus H-reflex and its modulation with vibration in 26 idiopathic toe walkers and 16 typically developing children...
April 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29573038/conditioned-pain-modulation-using-painful-cutaneous-electrical-stimulation-or-simply-habituation
#13
L Eitner, Ö S Özgül, E K Enax-Krumova, J Vollert, C Maier, O Höffken
BACKGROUND AND AIMS: Cold pressor test was recently reported to significantly reduce painful cutaneous electrical stimulation (PCES)-induced pain and corresponding evoked potentials (PCES-EPs), but whether this reduction is an effect of conditioned pain modulation (CPM) remains unknown. To what extent these findings are confounded by habituation is also unknown. We thus compared the effect of CPM and habituation on PCES-induced pain and PCES-EPs and analysed whether increased attention by a random change of electric stimulation would intensify this possible habituation effect...
March 23, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29567583/event-related-brain-potentials-elicited-by-high-speed-cooling-of-the-skin-a-robust-and-non-painful-method-to-assess-the-spinothalamic-system-in-humans
#14
Roxane De Keyser, Emanuel N van den Broeke, Arthur Courtin, André Dufour, André Mouraux
OBJECTIVE: To investigate whether cool-evoked potentials (CEP) elicited by brisk innocuous cooling of the skin could serve as an alternative to laser-evoked potentials (LEP), currently considered as the best available neurophysiological tool to assess the spinothalamic tract and diagnose neuropathic pain. METHODS: A novel device made of micro-Peltier elements and able to cool the skin at -300 °C/s was used to record CEPs elicited by stimulation of the hand dorsum in 40 healthy individuals, characterize the elicited responses, and assess their signal-to-noise ratio...
March 8, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29566852/role-of-medical-therapy-in-the-management-of-uterine-adenomyosis
#15
REVIEW
Silvia Vannuccini, Stefano Luisi, Claudia Tosti, Flavia Sorbi, Felice Petraglia
Adenomyosis is a benign uterine condition affecting women at various ages with different symptoms. The management of these patients is still controversial. Few clinical studies focusing on medical or surgical treatment for adenomyosis have been performed. No drug is currently labelled for adenomyosis and there are no specific guidelines to follow for the best management. Anyhow, medical treatments are effective in improving symptoms (pain, abnormal uterine bleeding and infertility). The rationale for using medical treatment is based on the pathogenetic mechanisms of adenomyosis: sex steroid hormones aberrations, impaired apoptosis, and increased inflammation...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29563830/different-mechanisms-of-contralateral-or-ipsilateral-acupuncture-to-modulate-the-brain-activity-in-patients-with-unilateral-chronic-shoulder-pain-a-pilot-fmri-study
#16
Shuai Zhang, Xu Wang, Chao-Qun Yan, Shang-Qing Hu, Jian-Wei Huo, Zhong-Yan Wang, Ping Zhou, Chun-Hong Liu, Cun-Zhi Liu
Background: Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with chronic pain, but the specific brain mechanisms under acupuncture treatment for CSP remain unclear. Therefore, in this study, we aimed to 1) compare the clinical effects between acupuncture at the contralateral and ipsilateral Tiaokou (ST 38) point in patients with unilateral shoulder pain and 2) explore how contralateral- and ipsilateral-acupuncture modulates the regional homogeneity (ReHo) of patients with CSP...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29562640/botulinum-toxin-b-affects-neuropathic-pain-but-not-functional-recovery-after-peripheral-nerve-injury-in-a-mouse-model
#17
Alba Finocchiaro, Sara Marinelli, Federica De Angelis, Valentina Vacca, Siro Luvisetto, Flaminia Pavone
Clinical use of neurotoxins from Clostridium botulinum is well established and is continuously expanding, including in treatment of pain conditions. Background : The serotype A (BoNT/A) has been widely investigated, and current data demonstrate that it induces analgesia and modulates nociceptive processing initiated by inflammation or nerve injury. Given that data concerning the serotype B (BoNT/B) are limited, the aim of the present study was to verify if also BoNT/B is able not only to counteract neuropathic pain, but also to interfere with inflammatory and regenerative processes associated with the nerve injury...
March 18, 2018: Toxins
https://www.readbyqxmd.com/read/29562624/gaba-and-gaba-alanine-from-the-red-microalgae-rhodosorus-marinus-exhibit-a-significant-neuro-soothing-activity-through-inhibition-of-neuro-inflammation-mediators-and-positive-regulation-of-trpv1-related-skin-sensitization
#18
Amandine Scandolera, Jane Hubert, Anne Humeau, Carole Lambert, Audrey De Bizemont, Chris Winkel, Abdelmajid Kaouas, Jean-Hugues Renault, Jean-Marc Nuzillard, Romain Reynaud
The aim of the present study was to investigate the neuro-soothing activity of a water-soluble hydrolysate obtained from the red microalgae Rhodosorus marinus Geitler (Stylonemataceae). Transcriptomic analysis performed on ≈100 genes related to skin biological functions firstly revealed that the crude Rhodosorus marinus extract was able to significantly negatively modulate specific genes involved in pro-inflammation (interleukin 1α encoding gene, IL1A) and pain detection related to tissue inflammation (nerve growth factor NGF and its receptor NGFR)...
March 17, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29562607/a-cohort-study-comparing-women-with-autism-spectrum-disorder-with-and-without-generalized-joint-hypermobility
#19
Emily L Casanova, Julia L Sharp, Stephen M Edelson, Desmond P Kelly, Manuel F Casanova
Reports suggest comorbidity between autism spectrum disorder (ASD) and the connective tissue disorder, Ehlers-Danlos syndrome (EDS). People with EDS and the broader spectrum of Generalized Joint Hypermobility (GJH) often present with immune- and endocrine-mediated conditions. Meanwhile, immune/endocrine dysregulation is a popular theme in autism research. We surveyed a group of ASD women with/without GJH to determine differences in immune/endocrine exophenotypes. ASD women 25 years or older were invited to participate in an online survey...
March 17, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29550675/morphine-reduced-perceived-anger-from-neutral-and-implicit-emotional-expressions
#20
Guro E Løseth, Marie Eikemo, Peder Isager, Jostein Holmgren, Bruno Laeng, Vigdis Vindenes, Trine Hjørnevik, Siri Leknes
The μ-opioid system modulates responses to pain and psychosocial stress and mediates non-social and social reward. In humans, the μ-opioid agonist morphine can increase overt attention to the eye-region and visual exploration of faces with neutral expressions. However, little is known about how the human μ-opioid system influences sensitivity to and appraisal of subtle and explicit cues of social threats and reward. Here, we examined the effects of selective μ-opioid stimulation on perception of anger and happiness in faces with explicit, neutral or implicit emotion expressions...
March 1, 2018: Psychoneuroendocrinology
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