keyword
MENU ▼
Read by QxMD icon Read
search

Aorta injury

keyword
https://www.readbyqxmd.com/read/28934276/enhanced-pyruvate-dehydrogenase-activity-improves-cardiac-outcomes-in-a-murine-model-of-cardiac-arrest
#1
Lin Piao, Yong-Hu Fang, Manfred M Kubler, Michael W Donnino, Willard W Sharp
RATIONALE: Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreased utilization of glucose to generate cellular ATP. Post-cardiac arrest (CA) hypothermia improves outcomes and alters metabolism, but its influence on PDH and PDK activity following CA are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28925322/unusual-intramural-coronary-artery-with-vertical-course-complicating-an-arterial-switch-operation
#2
Lok Sinha, Richard A Jonas, Pranava Sinha
Intramural coronary arteries in patients with d-transposition of the great arteries (d-TGA) usually arise from the opposite sinus of Valsalva and traverse horizontally across the posterior/facing commissure before emerging externally from the appropriate sinus of Valsalva. Failure to make appropriate technical modifications during coronary transfer can result in an important risk of posttransfer ischemia. We report a case with an unusual course of an intramural left anterior descending (LAD) coronary artery in a patient with d-TGA, with origin at the mid ascending aorta and a vertical intramural course, increasing the susceptibility to injury during an arterial switch operation (ASO)...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28915358/remote-myocardial-injury-the-protective-role-of-fluoxetine
#3
Muhittin Onur Yaman, Ibrahim Guner, Hayriye Erman, Olgu Enis Tok, Mukaddes Pala, Mukaddes Esrefoglu, Remisa Gelisgen, Hafize Uzun, Ugur Aksu, Nermin Yelmen, Emine Gulderen Sahin
Aortic cross-clamping induced ischemia reperfusion (IR) is an important factor in development of postoperative acute cardiac injury following abdominal aortic surgery. We investigated the possible antioxidant/anti-inflammatory effects of fluoxetine (FLX), which used widely as a preoperative anxiolytic, on cardiac injury induced by IR of infrarenal abdominal aorta. FLX was administered to IR (60-min ischemia and 120-min reperfusion) performed rats for 3 days, once daily at 20 mg/kg, i.p. dosage. Results were compared to control and non-FLX treated IR performed rats...
September 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28905300/p2x7r-antagonism-after-subfailure-overstretch-injury-of-blood-vessels-reverses-vasomotor-dysfunction-and-prevents-apoptosis
#4
Weifeng Luo, Daniel Feldman, Reid McCallister, Colleen Brophy, Joyce Cheung-Flynn
Human saphenous vein (HSV) is harvested and prepared prior to implantation as an arterial bypass graft. Injury and the response to injury from surgical harvest and preparation trigger cascades of molecular events and contribute to graft remodeling and intimal hyperplasia. Apoptosis is an early response after implantation that contributes the development of neointimal lesions. Here, we showed that surgical harvest and preparation of HSV leads to vasomotor dysfunction, increased apoptosis and downregulation of the phosphorylation of the anti-apoptotic protein, Niban...
September 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28894061/-successful-repair-of-chronic-expanding-hematoma-after-coronary-artery-bypass-grafting-by-lower-partial-sternotomy-approach-report-of-a-case
#5
Takateru Yamamoto, Kouhei Takahashi, Katsuaki Tsukioka, Tetsuya Kono
Chronic expanding hematoma (CEH) after coronary artery bypass grafting (CABG) is extremely rare. We reported a case of successful surgical repair of CEH through lower partial sternotomy approach. The patient was a 73-year-old man who underwent CABG. Fifteen years after the operation, he was admitted to referral hospital because of dyspnea on exertion. Echocardiography and computed tomography revealed a giant intrapericardial mass, which was pressing on the inferior wall of the ventricle. To avoid injury of the aorta and the patent bypass graft in the reentry of the chest, we selected lower partial sternotomy approach...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28893706/hypertension-acute-stent-thrombosis-and-paraplegia-6-months-after-tevar-for-blunt-thoracic-aortic-injury-in-a-22-year-old-patient
#6
O Martinelli, F Faccenna, A Malaj, J Jabbour, S Venosi, R Gattuso, B Gossetti, L Irace
TEVAR is a less invasive option for managing traumatic injuries of the descending aorta in polytraumatized patients. Concerns arise when treating young patients with TEVAR. A 22-year old male was admitted to the Emergency Department following a high-impact road traffic collision. Whole body CT scan documented multiple injuries, including rupture of descending thoracic aorta just below the isthmus. There was no evidence of paraplegia or stroke. We decided to treat him in an endovascular fashion with a Zenith Cook (Cook Incorporated, Bloomington, IN) endograft...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28888077/microrna-214-3p-a-link-between-autophagy-and-endothelial-cell-dysfunction-in-atherosclerosis
#7
Jing Wang, Wei-Na Wang, Shuang-Bin Xu, Hong Wu, Bing Dai, Dong-Dong Jian, Mei Yang, Yu-Tao Wu, Qiang Feng, Jian-Hua Zhu, Lei Zhang, Li Zhang
AIM: Endothelial cell injury assumes a fundamental part in the pathogenesis of atherosclerosis, and endothelial cell autophagy has protective effects on the development of atherosclerosis, though the underlying molecular regulation mechanism is indistinct. This study is aimed to investigate whether microRNA-214-3p (miR-214-3p) is involved in the endothelial cell autophagy regulation of atherosclerosis. METHODS: We utilized ApoE-/- mice provided with a high-fat diet (HFD) as atherosclerosis model...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28887256/remote-ischemic-preconditioning-decreases-the-magnitude-of-hepatic-ischemia-reperfusion-injury-on-a-swine-model-of-supraceliac-aortic-cross-clamping
#8
G Martikos, A Kapelouzou, M Peroulis, A Paspala, D Athanasiadis, A Maheras, T D Liakakos, K Moulakakis, S Vasdekis, A M Lazaris
BACKGROUND: Temporary hepatic ischemia is inevitable during open aortic surgery when supraceliac clamping is necessary, as in thoracoabdominal or pararenal aneurysms. Remote ischemic preconditioning (RIPC) has been described as a potential protective means against ischemia - reperfusion injury (IRI) in various tissues including the liver. The aim of this experimental study was to detect the effect of RIPC on liver IRI in a model of supraceliac aortic cross-clamping. METHODS: An animal study was performed...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28887239/atorvastatin-protect-kidney-from-remote-reperfusion-injury
#9
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda, João Victor Durães Gomes Oliva, Letícia do Espirito Santo Dias, Murillo Henrique Martins de Almeida, Trícia Luna Sampaio
BACKGROUND: There is a need to find an effective treatment against reperfusion injury. The aim of the present study was to evaluate the capacity of the ischemic postconditioning and statin to prevent renal reperfusion injury. DESIGN AND SETTING: An experimental study developed at Universidade Anhanguera-Uniderp. METHODS: A total of 41 Wistar rats were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postconditioning (IPC), postconditioning + statin (IPC + S), statin (S) and Sham...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28871193/estradiol-regulates-txnip-and-prevents-intermittent-hypoxia-induced-vascular-injury
#10
Xiao Fei Lan, Xiu Juan Zhang, Ying Ni Lin, Qiong Wang, Hua Jun Xu, Li Na Zhou, Pei Li Chen, Qing Yun Li
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for cardiovascular disease, but the estrogen replacement therapy is limited for its side effects. Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. In this study, we aimed to explore whether estradiol could protect against IH-induced vascular injury, and the possible effect of Trx-1/Txnip in this process...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865527/emergency-computed-tomography-angiogram-of-the-chest-abdomen-and-pelvis
#11
Kimberly Weatherspoon, Wayne Gilbertie, Tara Catanzano
In the setting of blunt trauma, the rapid assessment of internal injuries is essential to prevent potentially fatal outcomes. Computed tomography is a useful diagnostic tool for both screening and diagnosis. In addition to trauma, acute chest syndromes often warrant emergent computed tomographic angiography, looking for etiologies such as aortic aneurysms or complications of aortic aneurysms, or both, pulmonary emboli, as well as other acute vascular process like aortic dissection and Takayasu aortitis. With continued improvements in diagnostic imaging, computed tomographic angiography of the chest, abdominal and pelvis proves to be an effective modality to image the aorta and other major vascular structures...
August 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28865393/pediatric-aortoiliac-injury-following-blunt-abdominal-trauma-a-case-report
#12
Edward Daniele, Alan Coleman, Ben Hirsch, Thomas McGill, John Fitzwater
INTRODUCTION: The most common mechanism of aortic injury involves motor vehicle collisions resulting in aortic disruptions, occurring almost exclusively in the chest. Injury to the abdominal aorta following blunt trauma is nearly twenty times less likely to occur than the thoracic aorta. Because of the low incidence, there are few reports regarding the presentation and repair of these particular injuries, especially in the pediatric population. PRESENTATION OF CASE: We present a case of a 7-year-old boy involved in a high speed motor vehicle accident with an abdominal aorta transection at the aortic bifurcation extending into the left iliac artery...
July 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28862943/inter-relations-of-orthostatic-blood-pressure-change-aortic-stiffness-and-brain-structure-and-function-in-young-adults
#13
Leroy L Cooper, Jayandra J Himali, Alyssa Torjesen, Connie W Tsao, Alexa Beiser, Naomi M Hamburg, Charles DeCarli, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase, Gary F Mitchell
BACKGROUND: Relations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment. METHODS AND RESULTS: In a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age±SD, 47±8 years), we assessed orthostatic change in mean arterial pressure (MAP), aortic stiffness (carotid-femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging...
August 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28855960/resuscitative-endovascular-balloon-occlusion-of-the-aorta-in-trauma-a-systematic-review-of-the-literature
#14
REVIEW
Emiliano Gamberini, Federico Coccolini, Beatrice Tamagnini, Costanza Martino, Vittorio Albarello, Marco Benni, Marcello Bisulli, Nicola Fabbri, Tal Martin Hörer, Luca Ansaloni, Carlo Coniglio, Marco Barozzi, Vanni Agnoletti
AIMS: Resuscitative endovascular balloon occlusion of the aorta has been a hot topic in trauma resuscitation during these last years. The aims of this systematic review are to analyze when, how, and where this technique is performed and to evaluate preliminary results. METHODS: The literature search was performed on online databases in December 2016, without time limits. Studies citing endovascular balloon occlusion of the aorta in trauma were retrieved for evaluation...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28852401/aldehyde-dehydrogenase-2-overexpression-inhibits-neuronal-apoptosis-after-spinal-cord-ischemia-reperfusion-injury
#15
Xing-Zhen Liu, Xin Sun, Kang-Ping Shen, Wen-Jie Jin, Zhi-Yi Fu, Hai-Rong Tao, Zhi-Xing Xu
Aldehyde dehydrogenase 2 (ALDH2) is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury. Therefore, we hypothesized that ALDH2 could reduce spinal cord ischemia/reperfusion injury. Spinal cord ischemia/reperfusion injury was induced in rats using the modified Zivin's method of clamping the abdominal aorta. After successful model establishment, the agonist group was administered a daily consumption of 2.5% alcohol. At 7 days post-surgery, the Basso, Beattie, and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury group...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28846951/unstable-thoracic-spine-fracture-with-aortic-encroachment-a-potentially-fatal-association-and-a-suggested-treatment
#16
Francesco Cultrera, Emiliano Gamberini, Gustavo Iacono, Giorgio Ubaldo Turicchia, Vanni Agnoletti, Luigino Tosatto
BACKGROUND: The coexistence of an unstable spinal fracture with a pending aortic lesion is potentially catastrophic and a therapeutic challenge as to timing of treatment, assigning priorities and selecting the best approach. CASE REPORT: A 41 year-old healthy male victim of bike accident. Imaging revealed a fracture of 6th and 7th thoracic vertebrae with a bone fragment in close proximity to the descending thoracic aorta. After consultation with spine/vascular surgeons and interventional radiologists it was decided to secure the potential aortic injury with an endovascular stent-graft followed by posterior vertebral instrumentation for fracture's reduction...
August 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28839368/intervention-effects-of-atorvastatin-combined-with-panax-notoginseng-saponins-on-rats-with-atherosclerosis-complicated-with-hepatic-injury
#17
Qing-Fang Jiang, Min-Yi Huang, Kang-Yuan Wu, Jie-Ling Weng, Rong-Gui Deng, Xin-Jie Xu, Jian-Pei Xu, Tao Jiang
BACKGROUND: Statins cannot be used for some active liver diseases, which limits its application to some extent. The combined use of statins with other drugs may be one of the ways to solve this dilemma. OBJECTIVE: This research aims to evaluate the effects of atorvastatin combined with Panax notoginseng saponins (PNS) on rats with atherosclerosis (AS) complicated with hepatic injury. MATERIALS AND METHODS: Seventy-two male Wistar rats were randomly categorized into control group (without any intervention, Group A) and AS model groups, which were divided into hepatic injury (Groups B-E) and nonhepatic injury (Groups F-I) groups...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28835068/-effects-of-%C3%AF-3-polyunsaturated-fatty-acids-on-damage-of-intestinal-mucosa-of-rats-with-severe-burn-in-early-stage-and-the-mechanism
#18
C Cai, Z G Xia, Q L Xu, X Z Li
Objective: To observe the effects of ω-3 polyunsaturated fatty acids (PUFA) on damage of intestinal mucosa of rats with severe burn in early stage and to explore the mechanism. Methods: One hundred and twenty SD rats were divided into sham injury group, pure burn group, and ω-3 PUFA group according to the random number table, with 40 rats in each group. Rats in sham injury group were sham injured, while rats in pure burn group and ω-3 PUFA group were inflicted with 30% total body surface area full-thickness scald (hereinafter referred to as burn) on the back...
August 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28832798/avoiding-liver-injury-with-papaverine-and-ascorbic-acid-due-to-infrarenal-cross-clamping-an-experimental-study
#19
Serhat Huseyin, Orkut Guclu, Volkan Yüksel, Gulen Sezer Alptekin Erkul, Nuray Can, Fatma Nesrin Turan, Suat Canbaz
Objective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods: 32 Sprague-Dawley female rats were randomized into four groups (n=8)...
May 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28830209/puerarin-improves-vascular-insulin-resistance-and-cardiovascular-remodeling-in-salt-sensitive-hypertension
#20
Chunxiang Tan, Aimei Wang, Chan Liu, Yao Li, Yuepin Shi, Ming-Sheng Zhou
Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks...
August 22, 2017: American Journal of Chinese Medicine
keyword
keyword
42335
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"