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https://www.readbyqxmd.com/read/28731042/molecular-alterations-of-coexisting-thyroid-papillary-carcinoma-and-anaplastic-carcinoma-identification-of-tert-mutation-as-an-independent-risk-factor-for-transformation
#1
Naoki Oishi, Tetsuo Kondo, Aya Ebina, Yukiko Sato, Junko Akaishi, Rumi Hino, Noriko Yamamoto, Kunio Mochizuki, Tadao Nakazawa, Hiroshi Yokomichi, Koichi Ito, Yuichi Ishikawa, Ryohei Katoh
Thyroid papillary carcinoma is the most common endocrine neoplasm and generally carries a favorable prognosis. However, a small subset of papillary carcinomas transforms into anaplastic carcinoma, an undifferentiated cancer with a dismal prognosis. Recent studies using next-generation sequencing revealed the genomic landscape of papillary carcinoma and anaplastic carcinoma. However, risk factors for anaplastic transformation in papillary carcinoma remain obscure. In the present study, we investigated molecular alterations of papillary carcinoma and anaplastic carcinoma components in 27 tumors in which anaplastic carcinoma coexisted with antecedent papillary carcinoma...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28729834/white-matter-hyperintensity-in-elderly-patients-with-diabetes-mellitus-is-associated-with-cognitive-impairment-functional-disability-and-a-high-glycoalbumin-glycohemoglobin-ratio
#2
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki
Aims: Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment of activities of daily living (ADL), the clinical relevance of WMH in elderly patients with diabetes mellitus (DM) is not still clear. The aim of this study was to examine whether WMH volume is associated with ADL and cognitive function and whether glucose control and glucose variability can affect WMH volume in these patients. Methods: This cross-sectional study investigated the associations of WMH with cognitive function and instrumental ADL (IADL), as well as metabolic and vascular risk factors in a total of 178 elderly patients with diabetes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28729251/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#3
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loic Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazard model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28728538/effects-of-cataract-opacity-and-surgery-on-sleep-quality
#4
Aya Kokune, Masahiko Ayaki, Kazuo Tsubota, Kazuno Negishi
BACKGROUND: This study aimed to identify the type of cataract opacity associated with subjective sleep quality for cataract patients. METHODS: A total of 180 consecutive patients (average age 74.2 years) underwent cataract surgery with implantation of a UV-blocking or blue light-blocking intra ocular lens. The participants' subjective sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI) before and at 2 months after surgery. Patients were divided into two groups for analysis: normal sleepers (preoperative PSQI ≤ 5) and poor sleepers (preoperative PSQI ≥ 6)...
July 20, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28728162/realistic-lenalidomide-dose-adjustment-strategy-for-transplant-ineligible-elderly-patients-with-relapsed-refractory-multiple-myeloma-japanese-real-world-experience
#5
Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
Lenalidomide is an immunomodulatory drug administered orally in the treatment of multiple myeloma. Some elderly patients require a reduced lenalidomide dose because of comorbidities and/or adverse events. This study investigated the actual dose of lenalidomide in elderly patients, finding that most received reduced (5-10 mg) doses. The most common reasons for dose reduction were renal dysfunction (54% of patients), fatigue (grade ≥3; 20%), hematologic disorder (grade ≥3; 14%), and rash (grade ≥3; 9%)...
July 21, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28725491/ds16570511-is-a-small-molecule-inhibitor-of-the-mitochondrial-calcium-uniporter
#6
Naohiro Kon, Michiko Murakoshi, Aya Isobe, Katsuji Kagechika, Naoki Miyoshi, Takahiro Nagayama
In cardiac myocytes, regulation of mitochondrial Ca(2+) is important for cellular signaling and cardiac contraction. Ca(2+) entry into the mitochondria is mediated by a highly selective Ca(2+) channel called the mitochondrial calcium uniporter, which consists of a pore-forming subunit MCU and regulatory subunits such as MICU1. Although pharmacological regulation of the mitochondrial Ca(2+) influx is a promising approach to controlling the cellular functions, a cell-permeable and specific inhibitor of the mitochondrial calcium uniporter has not yet been developed...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28725387/origins-of-two-hemiclonal-hybrids-among-three-hexagrammos-species-teleostei-hexagrammidae-genetic-diversification-through-host-switching
#7
Hiroyuki Munehara, Miho Horita, Motoko R Kimura-Kawaguchi, Aya Yamazaki
Two natural, hemiclonal hybrid strains were discovered in three Hexagrammos species. The natural hybrids, all of which were females that produced haploid eggs containing only the Hexagrammos octogrammus genome (maternal ancestor; hereafter Hoc), generated F1 hybrid-type offspring by fertilization with haploid sperm of Hexagrammos agrammus or Hexagrammos otakii (paternal species; Hag and Hot, respectively). This study was performed to clarify the extent of diversification between the two hybrids and the maternal ancestor...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28723263/incidence-trends-of-cervical-cancer-in-adolescents-and-young-adults-brazilian-population-based-data
#8
Lucian da Silva Viana, Nathalie Vieira Balmant, Neimar de Paula Silva, Marceli de Oliveira Santos, Luiz Claudio Santos Thuler, Rejane de Souza Reis, Beatriz de Camargo
PURPOSE: High incidence rates for cervical cancer in adolescents and young adults (AYAs: 15-29 years) make this the most common carcinoma in Brazil. Our aim was to analyze the incidence trends for cervical cancer (CC) and in situ neoplasia (IsN) among this age group. METHODS: Incidence data were extracted from 21 Brazilian population-based cancer registries (PBCRs). Tumors with behavior code/3 (malignant) were classified as CC. Tumors with behavior code/2 were classified as IsN...
July 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28721279/age-related-circadian-disorganization-caused-by-sympathetic-dysfunction-in-peripheral-clock-regulation
#9
Yu Tahara, Yuta Takatsu, Takuya Shiraishi, Yosuke Kikuchi, Mayu Yamazaki, Hiroaki Motohashi, Aya Muto, Hiroyuki Sasaki, Atsushi Haraguchi, Daisuke Kuriki, Takahiro J Nakamura, Shigenobu Shibata
The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entrainment of peripheral clocks to external cues. We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28719293/case-report-clinical-features-of-a-case-of-suspected-borrelia-miyamotoi-disease-in-hokkaido-japan
#10
Kimiaki Yamano, Takuya Ito, Kaori Kiyanagi, Hirotaka Yamazaki, Mutsubu Sugawara, Takashige Saito, Norio Ohashi, Aya Zamoto-Niikura, Kozue Sato, Hiroki Kawabata
We herein report a case of suspected Borrelia miyamotoi disease in Hokkaido, Japan. The patient complained of lassitude, arthralgia, and high fever after a tick bite. Furthermore, at the time of consultation, the patient exhibited momentary loss of consciousness and low blood pressure. Laboratory tests revealed elevation of liver enzymes, thrombocytopenia, and increased C-reactive protein. Seroconversion to B. miyamotoi glycerophosphoryl diester phosphodiesterase antigen suggested the patient was infected with a relapsing fever group Borrelia species...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718765/a-connectome-of-a-learning-and-memory-center-in-the-adult-drosophila-brain
#11
Shin-Ya Takemura, Yoshinori Aso, Toshihide Hige, Allan Wong, Zhiyuan Lu, C Shan Xu, Patricia K Rivlin, Harald F Hess, Ting Zhao, Toufiq Parag, Stuart Berg, Gary Huang, William Katz, Donald J Olbris, Stephen Plaza, Lowell Umayam, Roxanne Aniceto, Lei-Ann Chang, Shirley Lauchie, Omotara Ogundeyi, Christopher Ordish, Aya Shinomiya, Christopher Sigmund, Satoko Takemura, Julie Tran, Glenn C Turner, Gerald M Rubin, Louis K Scheffer
Understanding memory formation, storage and retrieval requires knowledge of the underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of associative learning. We reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB's α lobe, using a dataset of isotropic 8-nm voxels collected by focused ion-beam milling scanning electron microscopy. We found that Kenyon cells (KCs), whose sparse activity encodes sensory information, each make multiple en passant synapses to MB output neurons (MBONs) in each compartment...
July 18, 2017: ELife
https://www.readbyqxmd.com/read/28718722/anticarcinogenic-effects-of-dried-citrus-peel-in-colon-carcinogenesis-due-to-inhibition-of-oxidative-stress
#12
Wakana Onuma, Daichi Asai, Susumu Tomono, Shingo Miyamoto, Gen Fujii, Takahiro Hamoya, Aya Nagano, Satoru Takahashi, Shoji Masumori, Noriyuki Miyoshi, Keiji Wakabayashi, Michihiro Mutoh
Colorectal cancer is one of the leading causes of death worldwide. Reactive oxygen species produce oxidative stress and contribute to colorectal carcinogenesis. Because dietary citrus has been shown to reduce oxidative stress, we investigated the effects of citrus peel extract at dilutions of 1/200-1/500 on the activity of oxidative-stress-related transcription factors, including AP-1, NF-κB, NRF2, p53, and STAT3, in human colon cancer cell line HCT116 cells using a luciferase reporter gene assay. NRF2 transcriptional activities were 1...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28718079/symptom-self-management-strategies-reported-by-adolescents-and-young-adults-with-cancer-receiving-chemotherapy
#13
Lauri A Linder, Jeanne M Erickson, Kristin Stegenga, Catherine Fiona Macpherson, Sarah Wawrzynski, Christina Wilson, Suzanne Ameringer
PURPOSE: Adolescents and young adults (AYAs) with cancer experience multiple symptoms related to their cancer and its treatment which can negatively impact their development and quality of life. An understanding of the strategies AYAs use to self-manage their symptoms is limited. This study described symptom self-management strategies reported by AYAs with cancer using an iPad-based symptom heuristics tool, the Computerized Symptom Capture Tool. METHODS: The study used a cross-sectional, descriptive design...
July 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28717089/an-autopsy-case-of-fulminant-hepatitis-in-a-patient-with-multiple-sclerosis-treated-by-interferon-beta-1a
#14
Yuichi Yamazaki, Aya Suzuki, Kimitoshi Hirayanagi, Yusuke Tsukagoshi, Ryota Uehara, Kazuhiko Horiguchi, Tatsuya Ohyama, Takuya Tomaru, Norio Horiguchi, Sumihito Nobusawa, Hayato Ikota, Ken Sato, Satoru Kakizaki, Motoyasu Kusano, Yoshio Ikeda, Hideaki Yokoo, Masanobu Yamada
A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH based on hepatic coma, severe liver injury and liver failure, and she received plasma exchange and continuous hemodiafiltration therapy. On hospital day 6, she died from liver failure despite intensive care. An autopsy revealed histological findings consistent with FH...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28714766/cancer-related-fatigue-in-adolescents-and-young-adults-after-cancer-treatment-persistent-and-poorly-managed
#15
Anna Spathis, Helen Hatcher, Sara Booth, Faith Gibson, Paddy Stone, Laura Abbas, Matt Barclay, James Brimicombe, Pia Thiemann, Martin G McCabe, Rachel Campsey, Louise Hooker, Wendy Moss, Jane Robson, Stephen Barclay
Cancer-related fatigue is the most prevalent and distressing symptom experienced by adolescents and young adults (AYAs). An electronic survey was undertaken to ascertain current fatigue management and perceptions of its effectiveness. Eighty-five percent of responders (68/80) experienced fatigue, and it was worse more than 1 year after cancer treatment ended, compared to <1 year (p = 0.007). Forty-one percent received no fatigue management. Although advice to exercise was the most frequent intervention, the greatest impact of fatigue was on the ability to exercise and most did not find exercise advice helpful...
July 17, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28713406/ultrastructural-and-cytological-studies-on-mycosphaerella-pinodes-infection-of-the-model-legume-medicago-truncatula
#16
Tomoko Suzuki, Aya Maeda, Masaya Hirose, Yuki Ichinose, Tomonori Shiraishi, Kazuhiro Toyoda
Ascochyta (Mycosphaerella) blight on cultivated peas is primarily caused by infection through asexual spores (pycnospores) of Mycosphaerella pinodes (Berk. et Blox.) Vestergren [recently renamed Peyronellaea pinodes (Berk. & A. Bloxam) Aveskamp, Gruyter & Verkley]. Using a model pathosystem involving Medicago truncatula and Mycosphaerella pinodes strain OMP-1, we examined the histology and ultrastructure of early infection events and fungal development including penetration by appressoria, vegetative growth of infection hyphae, and host responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712708/discovery-of-novel-2-3-phenylpiperazin-1-yl-pyrimidin-4-ones-as-glycogen-synthase-kinase-3%C3%AE-inhibitors
#17
Yoshihiro Usui, Fumiaki Uehara, Shinsuke Hiki, Kazutoshi Watanabe, Hiroshi Tanaka, Aya Shouda, Satoshi Yokoshima, Keiichi Aritomo, Takashi Adachi, Kenji Fukunaga, Shinji Sunada, Mika Nabeno, Ken-Ichi Saito, Jun-Ichi Eguchi, Keiji Yamagami, Shouichi Asano, Shinji Tanaka, Satoshi Yuki, Narihiko Yoshii, Masatake Fujimura, Takashi Horikawa
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues...
July 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28710338/unique-radiological-features-of-two-cases-of-primary-pulmonary-diffuse-large-b-cell-lymphoma
#18
Yuu Saitoh, Ayae Ohnishi-Amemiya, Michiyo Asano, Yuko Tanaka, Seiichiro Yoshizawa, Hiroaki Fujimoto, Yoshikazu Itoh, Naoya Nakamura, Kazuma Ohyashiki
No abstract text is available yet for this article.
July 14, 2017: Thorax
https://www.readbyqxmd.com/read/28709478/erratum-to-fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-iii-goal-directed-hemodynamic-therapy-rationale-for-maintaining-vascular-tone-and-contractility-rev-esp-anestesiol-reanim-2017-64-6-348-359
#19
J Ripollés-Melchor, D Chappell, H D Aya, Á Espinosa, M G Mythen, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
August 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28709477/erratum-to-fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-ii-goal-directed-hemodynamic-therapy-rationale-for-optimising-intravascular-volume-rev-esp-anestesiol-reanim-2017-64-6-339-347
#20
J Ripollés-Melchor, D Chappell, H D Aya, Á Espinosa, M G Mythen, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
August 2017: Revista Española de Anestesiología y Reanimación
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