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https://www.readbyqxmd.com/read/29676591/a-retrospective-observational-study-on-biological-drug-treatment-in-a-daily-practice-serving-patients-with-psoriasis-in-japan
#1
Chika Ohata, Bungo Ohyama, Aya Nanri, Takako Shintani, Takekuni Nakama
BACKGROUND: In Japan, more than 5 years have passed since emergence of the first 3 biologics, infliximab, adalimumab, and ustekinumab, became available in daily practice; however, no data for drug survival was reported from Japan. OBJECTIVE: To study the long-term drug survival of infliximab, adalimumab, and ustekinumab used for Japanese psoriatic patients. METHODS: We retrieved data on all patients treated with biological agents and calculated the long-term drug survival for infliximab, adalimumab, and ustekinumab using our psoriasis registry (Kurume Psoriasis Registry: KURUPR) consisted of 343 patients by the end of March 2017...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29674023/evaluation-of-portable-near-infrared-spectroscopy-for-organic-milk-authentication
#2
Ningjing Liu, Hector Aya Parra, Annemieke Pustjens, Kasper Hettinga, Philippe Mongondry, Saskia M van Ruth
Organic products are vulnerable to fraud due to their premium price. Analytical methodology helps to manage the risk of fraud and due to the miniaturization of equipment, tests may nowadays even be rapidly applied on-site. The current study aimed to evaluate portable near infrared spectroscopy (NIRS) in combination with chemometrics to distinguish organic milk from other types of milk, and compare its performance with benchtop NIRS and fatty acid profiling by gas chromatography. The sample set included 37 organic retail milks and 50 non-organic retail milks (of which 36 conventional and 14 green 'pasture' milks)...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673418/the-validation-of-the-dai-nippon-medi%C3%A2-ca-sa-method-for-aoac-research-institute-performance-tested-methods-sm-certification
#3
Mai Shimizu, Kentaro Takenaka, Takeo Suzuki, Aya Miyasaka, Taiki Matsuda, Tatsuhiko Iwase, Hitoshi Kyotani
A ready-made dry medium method for Staphylococcus aureus count, the Medi·Ca SA method incubated at 35 or 37°C, was compared with the Baird-Parker method (AOAC Official Method SM 975.55 ) for 11 food matrices: raw beef, raw ground beef, raw lamb, cooked ham, raw salmon, frozen prawn, fresh chilled pasta, pasteurized milk, natural cheese, cream puff, and potato salad. The mean difference between the two methods at each contamination level for each matrix was <0.5 log10 , and the 95% confidence intervals on the mean differences fell within the range of -0...
April 19, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29672604/the-effect-of-cigarillo-packaging-elements-on-young-adult-perceptions-of-product-flavor-taste-smell-and-appeal
#4
Clare Meernik, Leah M Ranney, Allison J Lazard, KyungSu Kim, Tara L Queen, Aya Avishai, Marcella H Boynton, Paschal J Sheeran, Adam O Goldstein
INTRODUCTION: Product packaging has long been used by the tobacco industry to target consumers and manipulate product perceptions. This study examines the extent to which cigarillo packaging influences perceptions of product flavor, taste, smell, and appeal. METHODS: A web-based experiment was conducted among young adults. Participants viewed three randomly selected cigarillo packs, varying on pack flavor descriptor, color, type, branding, and warning-totaling 180 pack images...
2018: PloS One
https://www.readbyqxmd.com/read/29672191/knowledge-and-beliefs-about-oncofertility-and-associations-with-quality-of-life-among-adolescent-and-young-adult-survivors-of-pediatric-cancer
#5
Andrea C Johnson, Darren Mays, Kathryn Rehberg, Aziza Shad, Kenneth P Tercyak
PURPOSE: Adolescent and young adult (AYA) cancer survivors experience fertility and childrearing challenges in adulthood, but there is limited evidence on awareness, beliefs, and concerns about oncofertility in this population, needs for supportive resources, and associations with quality of life (QoL). METHODS: Participants were 69 AYAs aged 12-25 who were diagnosed with cancer at age 18 years or younger and ≥1 year cancer free, recruited from childhood cancer clinical records and support organizations...
April 19, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29671286/assessment-of-potential-renal-dysfunction-in-patients-with-congenital-heart-disease-after-biventricular-repair
#6
Hideharu Oka, Kouichi Nakau, Aya Kajihama, Hiroshi Azuma
BACKGROUND AND OBJECTIVES: There are few reports on renal dysfunction in the remote period after biventricular repair, and biomarkers for early detection of renal dysfunction are not well understood. We examined whether early fluctuation of biomarkers of renal function occurs in the remote period after biventricular repair in patients with congenital heart disease (CHD). METHODS: Fourteen patients with CHD after biventricular repair were included. The examination values obtained by cardiac catheterization test and renal function indices based on blood and urine sampling were compared...
April 2, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29670152/improvement-of-cerebellar-ataxic-gait-by-injecting-cbln1-into-the-cerebellum-of-cbln1-null-mice
#7
Eri Takeuchi, Aya Ito-Ishida, Michisuke Yuzaki, Dai Yanagihara
Patients and rodents with cerebellar damage display ataxic gaits characterized by impaired coordination of limb movements. Here, gait ataxia in mice with a null mutation of the gene for the cerebellin 1 precursor protein (cbln1-null mice) was investigated by kinematic analysis of hindlimb movements during locomotion. The Cbln1 protein is predominately produced and secreted from cerebellar granule cells. The cerebellum of cbln1-null mice is characterized by an 80% reduction in the number of parallel fiber-Purkinje cell synapses compared with wild-type mice...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669756/patterns-of-care-and-outcomes-in-adolescent-and-young-adult-acute-lymphoblastic-leukemia-a-population-based-study
#8
Lori Muffly, Elysia Alvarez, Daphne Lichtensztajn, Renata Abrahão, Scarlett Lin Gomez, Theresa Keegan
Adolescents and young adults (AYAs, 15-39 years) with acute lymphoblastic leukemia (ALL) represent a heterogeneous population who receive care in pediatric or adult cancer settings. Using the California Cancer Registry, we describe AYA ALL patterns of care and outcomes over the past decade. Sociodemographics, treatment location, and front-line therapies administered to AYAs diagnosed with ALL between 2004 and 2014 were obtained. Cox regression models evaluated associations between ALL setting and regimen and overall survival (OS) and leukemia-specific survival (LSS) for the entire cohort, younger AYA (<25 years), and AYAs treated in the adult cancer setting only...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29667766/role-of-clinical-trials-in-survival-progress-of-american-adolescents-and-young-adults-with-cancer-and-lack-thereof
#9
Archie Bleyer, Eric Tai, Stuart Siegel
In the United States, adolescent and young adult (AYA) patients with cancer have the lowest clinical trial participation rate of all age groups and slower progress in survival improvement than younger patients. Ominously, AYA clinical trial participation has been steadily decreasing since 2010, except in 15-19 year olds and AYAs with acute lymphoblastic leukemia. In order to reverse the accrual trend, multiple changes are necessary, including convincing community oncologists to pursue clinical trials on behalf of their AYA patients and to have the new National Community Oncology Research Program and National Clinical Trials Network lead a coordinated effort to increase accrual...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667722/acute-myelogenous-leukemia-in-adolescents-and-young-adults
#10
REVIEW
Ursula Creutzig, Matthew A Kutny, Ronald Barr, Richard F Schlenk, Raul C Ribeiro
The incidence of acute myelogenous leukemia (AML) increases progressively with age. Favorable genetic mutations are most prevalent in children, and unfavorable profiles increase proportionately in adolescents and young adults (AYA) and into later adulthood. Survival rates of AYA have improved over recent decades to 50-60%, but their accrual to clinical trials remains poor. In contrast to AYA with acute lymphoblastic leukemia, the prognostic benefit for AYA with AML enrolled in pediatric compared with adult trials is minor and only seen when different protocols are used...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29665525/effects-of-pcr-inhibitors-on-mrna-expression-for-human-blood-identification
#11
Shusaku Matsumura, Aya Matsusue, Brian Waters, Masayuki Kashiwagi, Kenji Hara, Shin-Ichi Kubo
Detection of body fluid-specific mRNAs, such as those specific for blood, using real-time polymerase chain reaction (PCR) has become a useful tool in forensic science. Blood stains often contain PCR inhibitors that may be co-extracted with RNA and adversely affect PCR. The effects of inhibitors on the detection of mRNA markers for blood identification, namely, hemoglobin beta (HBB) and actin beta, were examined herein. Inhibitors were added to a real-time PCR mix, reverse transcription mix, and blood samples before RNA extraction, and the following parameters: Ct, delta Ct (dCt), and melting temperature (Tm) values, were monitored...
April 9, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29665250/a-genome-wide-association-study-of-coping-behaviors-suggests-fbxo45-is-associated-with-emotional-expression
#12
Chisato Shimanoe, Tsuyoshi Hachiya, Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Yoichi Sutoh, Atsushi Shimizu, Asahi Hishida, Sayo Kawai, Rieko Okada, Takashi Tamura, Keitaro Matsuo, Hidemi Ito, Etsuko Ozaki, Daisuke Matsui, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Hirokazu Uemura, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Kaori Endoh, Haruo Mikami, Yohko Nakamura, Yukihide Momozawa, Michiaki Kubo, Masahiro Nakatochi, Mariko Naito, Kenji Wakai
Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 13,088 participants aged 35-69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were measured and analyzed...
April 17, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#13
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29662611/gpx2-promotes-development-of-bladder-cancer-with-squamous-cell-differentiation-through-the-control-of-apoptosis
#14
Taku Naiki, Aya Naiki-Ito, Keitaro Iida, Toshiki Etani, Hiroyuki Kato, Shugo Suzuki, Yoriko Yamashita, Noriyasu Kawai, Takahiro Yasui, Satoru Takahashi
Herein, we elucidated the molecular mechanisms and therapeutic potential of glutathione peroxidase 2 (GPX2) in bladder cancer. GPX2 expression gradually increased during progression from normal to papillary or nodular hyperplasia (PNHP) and urothelial carcinoma (UC) in a rat N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced bladder carcinogenesis model. GPX2 overexpression was more marked in UC with squamous differentiation (SqD) than in pure UC. Clinical intraepithelial lesions of papillary UC and invasive UC with SqD also had strong GPX2 expression in human radical cystectomy specimens...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661546/strategy-for-the-accurate-preoperative-evaluation-of-the-number-of-metastatic-axillary-lymph-nodes-in-breast-cancer
#15
Nao Imai, Mika Kitayama, Akiko Shibahara, Yuri Bessho, Mai Shibusawa, Aya Noro, Keiko Inakami, Noriko Hanamura, Hiroshi Imai, Tomoko Ogawa
BACKGROUND: After the ACOSOG Z0011 trial, it became important to evaluate the number of metastatic axillary lymph nodes (LNs) preoperatively. The purpose of this paper is to confirm whether the number of metastases can be accurately diagnosed by preoperative computed tomography (CT), ultrasound sonography (US), and US-guided fine-needle aspiration cytology (FNAC). METHODS: We retrospectively analyzed the axillary LNs finding of preoperative CT/US of 470 breast cancer patients...
April 13, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29660338/different-molecular-mechanisms-of-htlv-1-and-hiv-ltr-activation-by-tpa
#16
Azhar Jabareen, Manal Salman, Aya Abu-Jaafar, Mahmoud Huleihel
HTLV-1 and HIV-1 are retroviruses involved in different human diseases. However, following infection, these viruses inter into a latent state. Tax and Tat are regarded as trans-activators of HTLV-1 and HIV-1 respectively. As it known, during the latent state the infected cells contain low Tax and Tat protein levels, so the activation of these viruses must be independent of these proteins. Here we focus on exploring the mechanism of activation of these viruses by 12-O-tetradecanoylphorbol-13-acetate (TPA), which is a potent activator of protein kinase C (PKC) and considered as a stress-inducing agent...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29660082/molecular-components-of-arabidopsis-intact-vacuoles-clarified-with-metabolomic-and-proteomic-analyses
#17
Miwa Ohnishi, Aya Anegawa, Yuko Sugiyama, Kazuo Harada, Akira Oikawa, Yasumune Nakayama, Fumio Matsuda, Yukiko Nakamura, Ryosuke Sasaki, Chizuko Shichijo, Patrick G Hatcher, Hidehiro Fukaki, Shigehiko Kanaya, Koh Aoki, Mami Yamazaki, Eiichiro Fukusaki, Kazuki Saito, Tetsuro Mimura
We analyzed the metabolites and proteins contained in pure intact vacuoles isolated from Arabidopsis suspension cultured cells using CE (capillary electrophoresis)-MS, FT-ICR (Fourier transform-ion cyclotron resonance)-MS and LC (Liquid chromatography)-MS. We identified 19 amino acids and 5 organic acids as major primary metabolites in the vacuoles with CE-MS. Further, we identified small amounts of 27 substances including well-known vacuolar molecules, but also some unexpected substances (for example, organic phosphate compounds)...
April 12, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29658616/multiple-tobacco-use-among-young-adult-waterpipe-smokers-in-egypt
#18
Aya Mostafa, Moustafa El Houssinie, Aisha Aboul Fotouh
Background: The use of multiple tobacco products is an emerging trend. Studies on multiple use among waterpipe smokers are limited. Objectives: We aimed to estimate the proportion of other tobacco products used by current adult waterpipe smokers in Egypt and identify the determinants of multiple tobacco product use. Methods: Population-based surveys were conducted using interview questionnaires during 2015-2017 in urban Cairo and rural Menoufia...
April 5, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29658430/adjuvant-pembrolizumab-versus-placebo-in-resected-stage-iii-melanoma
#19
Alexander M M Eggermont, Christian U Blank, Mario Mandala, Georgina V Long, Victoria Atkinson, Stéphane Dalle, Andrew Haydon, Mikhail Lichinitser, Adnan Khattak, Matteo S Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A Ascierto, Piotr Rutkowski, Dirk Schadendorf, Rutger Koornstra, Leonel Hernandez-Aya, Michele Maio, Alfonsus J M van den Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Paul Lorigan, Nageatte Ibrahim, Sandrine Marreaud, Alexander C J van Akkooi, Stefan Suciu, Caroline Robert
Background The programmed death 1 (PD-1) inhibitor pembrolizumab has been found to prolong progression-free and overall survival among patients with advanced melanoma. We conducted a phase 3 double-blind trial to evaluate pembrolizumab as adjuvant therapy in patients with resected, high-risk stage III melanoma. Methods Patients with completely resected stage III melanoma were randomly assigned (with stratification according to cancer stage and geographic region) to receive 200 mg of pembrolizumab (514 patients) or placebo (505 patients) intravenously every 3 weeks for a total of 18 doses (approximately 1 year) or until disease recurrence or unacceptable toxic effects occurred...
April 15, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29658261/survivorship-care-preferences-a-pilot-study-of-young-adults-with-cancer
#20
Adrienne Viola, Hannah-Rose Mitchell, Andrew Salner, Eileen Gillan, Jaime Rotatori, Brenda Cartmel, Sheila Santacroce, Xiaomei Ma, Nina Kadan-Lottick
Background: Adolescents and young adults (AYAs) face increased risk for physical, social, and cognitive late complications of cancer therapy. Strategies are needed to better engage AYAs in survivorship research. Objectives: This study aimed to determine the feasibility of enrolling AYAs within six months of diagnosis to a survivorship study and assess their health concerns and survivorship care preferences. Methods: Patients aged 15–34 years who were diagnosed with leukemia, lymphoma, or sarcoma at three Connecticut hospitals from 2008–2011 were identified and recruited by mail...
June 1, 2017: Clinical Journal of Oncology Nursing
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