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https://www.readbyqxmd.com/read/29452119/mirs-103-107-regulate-autophagy-in-the-epidermis
#1
Sijia Wang, Aya Kobeissi, Ying Dong, Nihal Kaplan, Wending Yang, Congcong He, Kang Zeng, Han Peng
We have shown that microRNAs-103 and -107(miRs-103/107) positively regulate end-stage autophagy via ensuring dynamin activity in cultured keratinocytes. Most work in end-stage autophagy has been conducted using in vitro model systems. In vivo regulation of end-stage autophagy in epidermis remains unknown. Here, we used antagomirs to subcutaneously knock-down miR-107 in the skin; conversely, we delivered miR-107 mimic subcutaneously via in vivo transfection to increase this miRNA. We found that antagomir-107 treatment in epidermis: (i) depleted endogenous miR-107; (ii) increased GFP-LC3 puncta in epidermal basal layers of GFP-LC3 transgenic mice, indicative of an accumulation of autophagosomes; (iii) inhibited LC3 turnover and increased p62, suggesting an inhibition of autophagy flux; and (iv) increased phosphorylated dynamin (p-dynamin, an inactive form), a key enzyme in end-stage autophagy...
February 13, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29450941/hematogenous-dissemination-of-mesenchymal-stem-cells-from-endometriosis
#2
Fei Li, Myles H Alderman, Aya Tal, Ramanaiah Mamillapalli, Alexis Coolidge, Demetra Hufnagel, Zhihao Wang, Elham Neisani, Stephanie Gidicsin, Graciela Krikun, Hugh S Taylor
Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissemination. Experimental endometriosis was established by transplanting endometrial tissue from DsRed+ mice into the peritoneal cavity of DsRed- mice. Using flow cytometry, we identified DsRed+ cells in blood of animals with endometriosis. The circulating donor cells expressed CXCR4 and mesenchymal stem cell (MSC) biomarkers, but not hematopoietic stem cell markers...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29450926/macroscopic-adhesion-of-thermoreversible-abc-triblock-copolymer-based-hydrogels-via-boronic-acid-sugar-complexation
#3
Ryota Tamate, Kotomi Takahashi, Takeshi Ueki, Aya Mizutani Akimoto, Ryo Yoshida
Two complementary thermoreversible ABC triblock copolymers containing either phenylboronic acids with low pK a values or galactosyl groups in the hydrophilic B blocks are synthesized by sequential reversible addition-fragmentation chain transfer polymerization and subsequent modification of the functional groups. Both ABC triblock copolymers undergo reversible sol-to-gel transitions upon temperature change and form physically cross-linked hydrogels under physiological conditions. Furthermore, the spontaneous adhesion of these thermoreversible hydrogels via the formation of boronic esters between the phenylboronic acid and galactosyl groups under physiological conditions is realized for the first time...
February 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29450465/pediatric-inspired-treatment-regimens-for-adolescents-and-young-adults-with-philadelphia-chromosome-negative-acute-lymphoblastic-leukemia-a-review
#4
Stuart E Siegel, Wendy Stock, Rebecca H Johnson, Anjali Advani, Lori Muffly, Dan Douer, Damon Reed, Mark Lewis, David R Freyer, Bijal Shah, Selina Luger, Brandon Hayes-Lattin, Jerry J Jaboin, Peter F Coccia, Daniel J DeAngelo, Nita Seibel, Archie Bleyer
Importance: The incidence of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in adolescent and young adult (AYA) patients (age range, 15-39 years) in the United States is increasing at a greater rate than in younger or older persons. Their optimal treatment has been increasingly debated as pediatric regimens have become more widely used in the age group. This review compares the basic features of pediatric and adult chemotherapy regimens for ALL and LBL, recognizes and describes the challenges of the pediatric regimen, and suggests strategies to facilitate its adoption for AYAs with ALL and LBL...
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29449217/zfp36l2-is-a-cell-cycle-regulated-ccch-protein-necessary-for-dna-lesion-induced-s-phase-arrest
#5
Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara
ZFP36L2 promotes the destruction of AU-rich element-containing transcripts, while its regulation and functional significance in cell cycle control are scarcely identified. We show that ZFP36L2 is a cell cycle-regulated CCCH protein whose abundance is regulated post-translationally at the respective stages of the cell cycle. Indeed, ZFP36L2 protein was eliminated after release from M phase, and ZYG11B-based E3 ligase plays a role in its polyubiquitination in interphase. Although ZFP36L2 is dispensable for normal cell cycle progression, we found that endogenous ZFP36L2 played a key role in cisplatin-induced S-phase arrest, a process in which the suppression of G1/S cyclins is necessary...
February 15, 2018: Biology Open
https://www.readbyqxmd.com/read/29448034/bombyx-mori-homolog-of-tumor-suppressor-p53-is-involved-in-apoptosis-mediated-antiviral-immunity-of-b-mori-cells-infected-with-nucleopolyhedrovirus
#6
Shizuka Makino, Rina Hamajima, Aya Saito, Moe Tomizaki, Asako Iwamoto, Michihiro Kobayashi, Hayato Yamada, Motoko Ikeda
Apoptosis is important in antiviral immunity and affects viral multiplication and pathogenesis. Here, we showed that Bombyx mori cells transiently expressing B. mori homolog of the tumor suppressor p53 (Bm-p53) protein underwent apoptosis accompanied by elevated caspase-3-like protease activity and processing of B. mori Dronc (Bm-Dronc). RNAi-mediated silencing of bm-p53 expression, which significantly diminished accumulation of bm-p53 transcript and Bm-p53 protein, prevented apoptosis of B. mori cells infected with a recombinant B...
February 12, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29446670/diagnostic-performance-of-margin-features-in-thyroid-nodules-in-prediction-of-malignancy
#7
Sean M Siebert, Adam J Gomez, Tie Liang, Ali M Tahvildari, Terry S Desser, R Brooke Jeffrey, Aya Kamaya
OBJECTIVE: The purpose of this study was to evaluate thyroid nodule margins for specific morphologic features and determine the diagnostic performance of these features in differentiating papillary carcinoma from benign thyroid nodules. MATERIALS AND METHODS: Nodules measuring 1-3 cm in largest diameter that had been evaluated with high-resolution ultrasound (12-18 MHz) and ultrasound-guided biopsy with definitive pathologic diagnosis were analyzed. Three blinded board-certified readers evaluated high-resolution images of each nodule for jagged edges, lobulated borders, and curved borders along their margins...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29446056/hypothesis-structural-heterogeneity-of-the-unfolded-proteins-originating-from-the-coupling-of-the-local-clusters-and-the-long-range-distance-distribution
#8
REVIEW
Satoshi Takahashi, Aya Yoshida, Hiroyuki Oikawa
We propose a hypothesis that explains two apparently contradicting observations for the heterogeneity of the unfolded proteins. First, the line confocal method of the single-molecule Förster resonance energy transfer (sm-FRET) spectroscopy revealed that the unfolded proteins possess broad peaks in the FRET efficiency plot, implying the significant heterogeneity that lasts longer than milliseconds. Second, the fluorescence correlation method demonstrated that the unfolded proteins fluctuate in the time scale shorter than 100 ns...
February 14, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29445282/orexin-hypocretin-levels-in-the-cerebrospinal-fluid-and-characteristics-of-patients-with-myotonic-dystrophy-type-1-with-excessive-daytime-sleepiness
#9
Yuki Omori, Takashi Kanbayashi, Aya Imanishi, Ko Tsutsui, Yohei Sagawa, Yuka S Kikuchi, Masahiro Takeshima, Kazuhisa Yoshizawa, Sachiko Uemura, Tetsuo Shimizu
Purpose: Myotonic dystrophy type 1 (DM1) is often characterized by excessive daytime sleepiness (EDS) and sleep-onset rapid eye movement periods caused by muscleblind-like protein 2. The EDS tends to persist even after treatment of sleep apnea. We measured the cerebrospinal fluid (CSF) orexin levels in DM1 patients with EDS and compared the clinical characteristics with narcolepsy type 1 and idiopathic hypersomnia (IHS) patients. Patients and methods: We measured the CSF orexin levels in 17 DM1 patients with EDS and evaluated subjective sleepiness using the Epworth Sleepiness Scale (ESS), objective sleepiness using mean sleep latency (MSL), and sleep apnea using apnea-hypopnea index (AHI)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29445261/on-asphericity-of-convex-bodies-in-linear-normed-spaces
#10
Nashat Faried, Ahmed Morsy, Aya M Hussein
In 1960, Dvoretzky proved that in any infinite dimensional Banach space X and for any [Formula: see text] there exists a subspace L of X of arbitrary large dimension ϵ -iometric to Euclidean space. A main tool in proving this deep result was some results concerning asphericity of convex bodies. In this work, we introduce a simple technique and rigorous formulas to facilitate calculating the asphericity for each set that has a nonempty boundary set with respect to the flat space generated by it. We also give a formula to determine the center and the radius of the smallest ball containing a nonempty nonsingleton set K in a linear normed space, and the center and the radius of the largest ball contained in it provided that K has a nonempty boundary set with respect to the flat space generated by it...
2018: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29442287/recent-developments-in-adolescent-and-young-adult-aya-acute-lymphoblastic-leukemia
#11
REVIEW
Victor M Orellana-Noia, Michael G Douvas
PURPOSE OF REVIEW: Adolescent and Young Adult (AYA) Oncology is a relatively new field encompassing research in the unique pathophysiology, clinical care, and psychosocial issues facing patients between the ages of 15 and 40 with cancer. About 100,000 of the approximately 1.5 million people diagnosed annually with cancer in the USA are in this age range. This chapter will review notable new developments in the care of adolescents and young adults with acute lymphoblastic leukemia (ALL) within the last 3 years...
February 14, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29442281/neutrophil-to-lymphocyte-ratio-as-an-early-marker-of-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer-treated-with-nivolumab
#12
Aya Nakaya, Takayasu Kurata, Hiroshige Yoshioka, Yuki Takeyasu, Maiko Niki, Kayoko Kibata, Naoko Satsutani, Makoto Ogata, Takayuki Miyara, Shosaku Nomura
BACKGROUND: There is an unmet need to identify markers that predict the response to nivolumab in patients with non-small-cell lung cancer (NSCLC). The neutrophil-to-lymphocyte ratio (NLR) was recently recognized as an indicator of a poor prognosis in patients with various cancers. In the present study, we quantified the predictive impact of NLR in patients with NSCLC treated with nivolumab. METHODS: We retrospectively analyzed 101 patients with advanced NSCLC treated with nivolumab at Kansai Medical University Hospital from December 2015 to December 2016...
February 13, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29441328/cellular-tight-junctions-prevent-effective-campylobacter-jejuni-invasion-and-inflammatory-barrier-disruption-promoting-bacterial-invasion-from-lateral-membrane-in-polarized-intestinal-epithelial-cells
#13
Sho Hatayama, Takaaki Shimohata, Sachie Amano, Junko Kido, Anh Q Nguyen, Yuri Sato, Yuna Kanda, Aya Tentaku, Shiho Fukushima, Mutsumi Nakahashi, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi
Campylobacter jejuni invasion is closely related to C. jejuni pathogenicity. The intestinal epithelium contains polarized epithelial cells that form tight junctions (TJs) to provide a physical barrier against bacterial invasion. Previous studies indicated that C. jejuni invasion of non-polarized cells involves several cellular features, including lipid rafts. However, the dynamics of C. jejuni invasion of polarized epithelial cells are not fully understood. Here we investigated the interaction between C. jejuni invasion and TJ formation to characterize the mechanism of C...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29437492/the-experience-of-adolescents-and-young-adults-treated-for-cancer-in-an-adult-setting-a-review-of-the-literature
#14
Steve Marshall, Anne Grinyer, Mark Limmer
The purpose of this review is to explore the literature on the experience of adolescents and young adults (AYAs) having cancer treatment in an adult setting, rather than on a specialist adolescent cancer unit. The integrative review method was used to explore the current literature. Primary research on the topic was located systematically and then synthesized into a thematic narrative. The experience of AYAs undergoing treatment in an adult setting was generally negative. This can be attributed to three themes: feeling isolated in the adult setting; the lack of empathy from staff working in the adult setting; and the inappropriateness of the adult environment for this age group...
February 13, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29435137/activation-of-mapk-signalling-results-in-resistance-to-saracatinib-azd0530-in-ovarian-cancer
#15
Niamh McGivern, Aya El-Helali, Paul Mullan, Iain A McNeish, D Paul Harkin, Richard D Kennedy, Nuala McCabe
SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease. The SAPPROC trial investigated the addition of the SRC inhibitor saracatinib (AZD0530) to weekly paclitaxel for the treatment of platinum resistant ovarian cancer; however, this drug combination did not provide any benefit to progression free survival (PFS) of women with platinum resistant disease...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434445/behind-the-curtain-of-non-coding-rnas-long-non-coding-rnas-regulating-hepatocarcinogenesis
#16
REVIEW
Aya El Khodiry, Menna Afify, Hend M El Tayebi
Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs (lncRNAs) are RNAs with a length greater than 200 nucleotides that do not encode proteins. lncRNAs can regulate gene expression and protein synthesis in several ways by interacting with DNA, RNA and proteins in a sequence specific manner. They could regulate cellular and developmental processes through either gene inhibition or gene activation...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29434290/induction-of-differentiation-of-intrahepatic-cholangiocarcinoma-cells-to-functional-hepatocytes-using-an-organoid-culture-system
#17
Yoshimasa Saito, Toshiaki Nakaoka, Toshihide Muramatsu, Hidenori Ojima, Aoi Sukeda, Yuko Sugiyama, Ryoei Uchida, Ryo Furukawa, Aya Kitahara, Toshiro Sato, Yae Kanai, Hidetsugu Saito
Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis often develop IHCC, it has been suggested that transformed hepatocytes may play a role in IHCC development. To investigate whether IHCC cells can be converted to functional hepatocytes, we established organoids derived from human IHCC and cultured them under conditions suitable for hepatocyte differentiation...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434164/nivolumab-induces-sustained-liver-injury-in-a-patient-with-malignant-melanoma-a-case-report
#18
Tokuhiro Matsubara, Tsutomu Nishida, Yu Higaki, Ryo Tomita, Hiromi Shimakoshi, Akiyoshi Shimoda, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Dai Nakamatsu, Kaori Mukai, Masashi Yamamoto, Koji Fukui, Shiro Adachi, Masami Inada
A 42-year-old man was diagnosed with cStage IIIb malignant melanoma and underwent resection. After interferon-beta therapy, 18-fluorodeoxyglucose-positron emission tomography/computed tomography ( 18 F-FDG PET/CT) showed multiple lung metastases, and he received nivolumab (2 mg/kg) every 3 weeks, resulting in a total of 17 cycles. After treatment, 18 F-FDG PET/CT showed a significant decrease in the size of the metastases, but he had a Grade 4 ALT elevation. Liver histology revealed drug-induced liver damage...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29434151/primary-central-nervous-system-post-transplant-lymphoproliferative-disorder-diagnosed-by-peripheral-facial-nerve-palsy
#19
Aya Imafuku, Kiho Tanaka, Yuji Marui, Yoshifumi Ubara, Kenmei Takaichi, Shinji Tomikawa, Yasunori Ota, Takeshi Fujii, Yasuo Ishii
Although primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) causes various symptoms depending on the tumor region, there has been no previous report of PCNS-PTLD in the cerebellopontine angle that was diagnosed due to peripheral facial nerve palsy. We herein report a case involving a 62-year-old man with PCNS-PTLD in the cerebellopontine angle who was diagnosed due to peripheral facial nerve palsy. The reduction of immunosuppressive therapy, whole-brain radiotherapy, intrathecal chemotherapy, and rituximab were effective in treating this patient...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432662/associations-of-overweight-obesity-and-socioeconomic-status-with-hypertension-prevalence-across-racial-and-ethnic-groups
#20
Deborah Rohm Young, Heidi Fischer, David Arterburn, Daniel Bessesen, Lee Cromwell, Matthew F Daley, Jay Desai, Assiamira Ferrara, Stephanie L Fitzpatrick, Michael A Horberg, Corinna Koebnick, Claudia L Nau, Caryn Oshiro, Beth Waitzfelder, Ayae Yamamoto
Racial/ethnic disparities in the prevalence of diagnosed hypertension are persistent but may be partially explained by racial/ethnic differences in weight category and neighborhood socioeconomic status. The authors compared hypertension prevalence rates among 4 060 585 adults with overweight or obesity across 10 healthcare systems by weight category and neighborhood education level in geographically and racially diverse individuals. Data were obtained from electronic health records. Hypertension was defined as at least two outpatient visits or one inpatient hospitalization with a coded diagnosis...
February 12, 2018: Journal of Clinical Hypertension
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