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subclinical hyperthyroidism

Sudipa Sarkar, Lindsay A Bischoff
Hyperthyroidism can occur during pregnancy and the postpartum period, and the treatment of hyperthyroidism should be considered in the preconception phase. Pregnancy has multiple normal physiologic effects on thyroid hormone, which is a separate process distinct from syndromes such as transient hyperthyroidism of hyperemesis gravidarum. The rationale regarding antithyroid drug use during different stages of pregnancy is reviewed, including the literature regarding adverse neonatal outcomes such as aplasia cutis and methimazole embryopathy in the setting of first trimester maternal methimazole use...
October 14, 2016: Seminars in Reproductive Medicine
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
Albino Petrone, Flaminio Mormile, Giacomo Bruni, Michela Quartieri, Maria R Bonsignore, Oreste Marrone
OBJECTIVE: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment...
July 2016: Sleep Medicine
Carole Rieben, Daniel Segna, Bruno R da Costa, Tinh-Hai Collet, Layal Chaker, Carole E Aubert, Christine Baumgartner, Osvaldo P Almeida, Eef Hogervorst, Stella Trompet, Kamal Masaki, Simon P Mooijaart, Jacobijn Gussekloo, Robin P Peeters, Douglas C Bauer, Drahomir Aujesky, Nicolas Rodondi
CONTEXT: While both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. OBJECTIVE: To determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. DATA SOURCES: Search in MEDLINE, EMBASE until November 2014. STUDY SELECTION: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination, MMSE)...
September 30, 2016: Journal of Clinical Endocrinology and Metabolism
Nissim Arbib, Eran Hadar, Orly Sneh-Arbib, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
PURPOSE: Maternal thyroid gland dysfunction may adversely affect pregnancy outcome. We aimed to examine the association between subclinical thyroid dysfunction, both hypothyroidism and hyperthyroidism, to adverse pregnancy outcome. MATERIALS AND METHODS: Retrospective cohort study of all women with an available first trimester thyroid function testing and known pregnancy outcome, categorized to subclinical hypothyroidism, or hyperthyroidism and evaluated for complication during gestation and delivery...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
Bo Ding, Ying Zhang, Qian Li, Yun Hu, Xiao-Jun Tao, Bing-Li Liu, Jian-Hua Ma, Dong-Mei Li
BACKGROUND AND AIMS: To determine the relationship between thyroid stimulating hormone (TSH) and bone mineral density (BMD) in elderly women. METHODS: This is a retrospective cross-sectional population cohort study of women aged ≥65 years. All 1097 subjects had no overt thyroid dysfunction, 47 had subclinical hyperthyroidism and 100 had subclinical hypothyroidism. Overall, 167 had normal BMD, 594 had osteopenia and 336 had osteoporosis. RESULTS: The femoral neck (FN) BMD was lower in women with lower TSH, with a high prevalance of osteoporosis and osteopenia (p = 0...
May 2016: Archives of Medical Research
Pierre Bel Lassen, Aglaia Kyrilli, Maria Lytrivi, Maria Ruiz Patino, Bernard Corvilain
OBJECTIVE: The effects of endogenous subclinical hyperthyroidism (eSCH) on heart and bone have been well documented. There are only limited data available regarding the impact of eSCH on weight regulation and lipid metabolism. Our aim was to evaluate the changes in body weight and metabolic parameters after total thyroidectomy in patients with pre-operative eSCH compared with pre-operative patients with euthyroid (EUT). DESIGN: A retrospective study of 505 patients who underwent total thyroidectomy for benign multinodular goitre in an academic hospital in Brussels (Belgium) was performed...
September 21, 2016: Clinical Endocrinology
Nunzia Brusca, Camilla Virili, Miriam Cellini, Silvia Capriello, Lucilla Gargano, Rita Salvatori, Marco Centanni, Maria Giulia Santaguida
OBJECTIVE: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH. This study was aimed at comparing the rate of autonomously functioning areas and their cardiac sequelae in patients with nodular goitre studied with the usual and a novel approach. DESIGN AND METHODS: A total of 490 adult outpatients with thyroid nodular goitre, living in a mild iodine-deficient area, were selected in our Referral Center for thyroid diseases from 2009 to 2014 on the basis of a suspicion of thyroid functional autonomy...
September 19, 2016: European Journal of Endocrinology
Kenneth A Woeber
No abstract text is available yet for this article.
September 15, 2016: Endocrine Practice
Olusoji Mayowa Ige, Kehinde Sola Akinlade, Sheu Kadiri Rahamon, Victory Fabian Edem, Olatunbosun Ganiyu Arinola
BACKGROUND: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDR-TB. OBJECTIVES: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy...
June 2016: African Health Sciences
Won Sang Yoo, Hyun Kyung Chung
Autoimmune thyroid disease (AITD) includes hyperthyroid Graves disease, hypothyroid autoimmune thyroiditis, and subtle subclinical thyroid dysfunctions. AITD is caused by interactions between genetic and environmental predisposing factors and results in autoimmune deterioration. Data on polymorphisms in the AITD susceptibility genes, related environmental factors, and dysregulation of autoimmune processes have accumulated over time. Over the last decade, there has been progress in the clinical field of AITD with respect to the available diagnostic and therapeutic methods as well as clinical consensus...
September 2016: Endocrinology and Metabolism
Mervat M El-Eshmawy, Mona M Arafa, Rasha R Elzehery, Rania M Elhelaly, Mohamed M Elrakhawy, Azza A El-Baiomy
Vitamin A deficiency (VAD) and altered thyroid function are commonly encountered in patients with liver cirrhosis. The link between vitamin A metabolism and thyroid function has been previously identified. The aim of this study was to explore the association between VAD and the thyroid axis in clinically stable patients with cirrhosis related to hepatitis C virus (HCV). One hundred and twelve patients with clinically stable HCV-related cirrhosis and 56 healthy controls matched for age, sex, and socioeconomic status were recruited for this study...
September 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Simon Hs Pearce, Salman Razvi, Mohammad E Yadegarfar, Carmen Martin-Ruiz, Andrew Kingston, Joanna Collerton, Theo J Visser, Tom B Kirkwood, Carol Jagger
CONTEXT: Perturbations in thyroid function are common in older individuals but their significance in the very old is not fully understood. OBJECTIVE: To determine whether thyroid hormone status and variation of thyroid hormones within the reference range correlated with mortality and disability in a cohort of 85-year-olds. DESIGN: A cohort of 85-year-old individuals were assessed in their own homes (community or institutional care) for health status and thyroid function, and followed for mortality and disability for up to 9 years...
August 23, 2016: Journal of Clinical Endocrinology and Metabolism
Ulla T Schultheiss, Natalie Daya, Morgan E Grams, Jochen Seufert, Michael Steffes, Josef Coresh, Elizabeth Selvin, Anna Köttgen
BACKGROUND: Reduced kidney function is a common public health problem that increases risk for a wide variety of adverse outcomes, making the identification of potentially modifiable factors associated with the development of incident chronic kidney disease (CKD) important. Alterations in the hypothalamic-pituitary-thyroid axis have been linked to reduced kidney function, but the association of thyroid function with the development of incident CKD is largely uncharacterized. METHODS: Concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3) and thyroid peroxidase antibody (TPOAb) were quantified in 12 785 black and white participants of the ongoing community-based prospective Atherosclerosis Risk in Communities study...
August 18, 2016: Nephrology, Dialysis, Transplantation
Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
Thyrotoxicosis is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormones. Including its subclinical form, it is considered as one of the most frequent endocrine disorders in the general population. If not detected in a timely fashion, thyrotoxicosis can have serious health consequences. The most common forms of thyrotoxicosis include diffuse toxic goiter (Graves' disease), toxic multinodular goiter (Plummer's disease), and toxic adenoma (Goetsch's disease). The significant progress in the fields of hormonal assessment, imaging procedures and molecular biology made in recent years has brought about great improvement in the identification, differentiation and treatment of many other disorders associated with thyrotoxicosis...
2016: Przegla̧d Lekarski
H I Gözü, S Özçelik, M Aloğlu, A Şahin, S Temiz, A Dayan, H Cengiz, Y Tütüncü, R Bircan
The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D727E polymorphism in 123 patients and 97 healthy subjects using the polymerase chain reaction-restriction fragment length polymorphism technique...
2016: Genetics and Molecular Research: GMR
Connie M Rhee, Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, Steven Kim, Jiaxi Wang, Danh V Nguyen, Csaba P Kovesdy, Gregory A Brent, Kamyar Kalantar-Zadeh
CONTEXT AND OBJECTIVE: End-stage renal disease patients have a higher risk of thyroid disease compared to those without kidney disease. While thyroid dysfunction is associated with higher death risk in the general population and those undergoing hemodialysis, little is known about the impact of thyroid disease upon mortality in peritoneal dialysis (PD) patients. Design, Setting, Participants, and Main Outcome: We examined the association of thyroid status, assessed by serum TSH, with all-cause mortality among PD patients from a large national dialysis organization who underwent one or more TSH measurements over five years (1/2007-12/2011)...
August 15, 2016: Journal of Clinical Endocrinology and Metabolism
Douglas S Ross, Henry B Burch, David S Cooper, M Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A Rivkees, Mary Samuels, Julie Ann Sosa, Marius N Stan, Martin A Walter
BACKGROUND: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspecialty physicians and others providing care for patients with this condition. METHODS: The American Thyroid Association (ATA) previously cosponsored guidelines for the management of thyrotoxicosis that were published in 2011...
October 2016: Thyroid: Official Journal of the American Thyroid Association
P D Maldjian, T Chen
AIM: To determine if visual assessment of the attenuation of morphologically normal appearing thyroid glands on unenhanced computed tomography (CT) of the chest is useful for identifying patients with decreased thyroid function. MATERIALS AND METHODS: This was a retrospective study of 765 patients who underwent both unenhanced CT of the chest and thyroid function tests performed within 1 year of the CT examination. Attenuation of the thyroid gland was visually assessed in each patient relative to the attenuation of the surrounding muscles to categorise the gland as "low attenuation" (attenuation similar to surrounding muscles) or "high attenuation" (attenuation greater than surrounding muscles)...
November 2016: Clinical Radiology
John P Walsh
Serum thyroid-stimulating hormone (TSH) testing is the best screening tool for thyroid dysfunction. When TSH levels are in the reference range, additional tests such as free thyroxine, free triiodothyronine or thyroid antibodies rarely add value, except in patients with pituitary disease, when TSH is unreliable. Overt hypothyroidism and subclinical hypothyroidism with TSH levels > 10 mU/L can be treated without further investigation. The health impact of subclinical hypothyroidism with mildly elevated levels of TSH (4-10 mU/L) remains uncertain, particularly in older people; treatment or observation are reasonable options...
August 15, 2016: Medical Journal of Australia
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