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Yi-Lin Zhang, Jia-Wen Xu, Xiong-Hao Wu, Peng-Xiao Chen, Fang Wei, Dong-Dong Gao, Xiao-Wen Chen, Yu-Li Luo, Yun-Xin Zhu, Jiehong Huang, Ya-Xia Tan, Lei Zhao, Wen-Liang Zhou
Sodium tanshinone IIA sulphonate, a water-soluble derivative of tanshinone IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive. This paper presents a study on the relaxant effect and underlying mechanisms of sodium tanshinone IIA sulphonate on mouse tracheal smooth muscle. The relaxant effect of sodium tanshinone IIA sulphonate was evaluated in mouse tracheal rings using a mechanical recording system. Intracellular Ca(2+) concentration was measured in primary cultured tracheal smooth muscle cells using confocal imaging system...
December 9, 2016: Planta Medica
Wei Wang, Qiu-Hong Wu, Yong Sui, Yan Wang, Xin Qiu
High glucose induced endothelial dysfunction is blamed for initiation of vascular complication in Type 2 diabetes mellitus. Rutin has been described in possessing comprehensive pharmacological activities, but the mechanism involved in endothelial protection through regulating oxidative stress and damage is still ambiguous. In the present study, rutin was evaluated in high glucose stimulated human umbilical vein endothelial cells (HUVECs) and high glucose diet-treated SD rats were applied to explored the molecular mechanism in rutin counteracting oxidative stress and damage...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Aisha El-Hawli, Tawar Qaradakhi, Alan Hayes, Emma Rybalka, Renee Smith, Martin Caprnda, Radka Opatrilova, Katarina Gazdikova, Maria Benckova, Peter Kruzliak, Anthony Zulli
Coronary artery vasospasm (constriction) caused by reduced nitric oxide bioavailability leads to myocardial infarction. Reduced endothelial release of nitric oxide by the neurotransmitter acetylcholine, leads to paradoxical vasoconstriction as it binds to smooth muscle cell M3 receptors. Thus, inhibition of coronary artery vasospasm will improve clinical outcomes. Inhibition of insulin regulated aminopeptidase has been shown to improve vessel function, thus we tested the hypothesis that HFI419, an inhibitor of insulin regulated aminopeptidase, could reduce blood vessel constriction to acetylcholine...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bart Torensma, Chris H Martini, Martijn Boon, Erik Olofsen, Bas In 't Veld, Ronald S L Liem, Mireille T T Knook, Dingeman J Swank, Albert Dahan
BACKGROUND: It remains unknown whether the administration of a deep neuromuscular block (NMB) during bariatric surgery improves surgical conditions and patient outcome. The authors studied the effect of deep versus moderate NMB in laparoscopic bariatric surgery on surgical conditions and postoperative pain. METHODS AND RESULTS: One hundred patients scheduled to undergo elective bariatric surgery were randomized to a deep NMB (post-tetanic-count 2-3) or a moderate NMB (train-of-four 1-2)...
2016: PloS One
Carolina Caniffi, Flavia M Cerniello, María N Gobetto, María L Sueiro, María A Costa, Cristina Arranz
Given that the role of C-type natriuretic peptide (CNP) in the regulation of vascular tone in hypertensive states is unclear, we hypothesized that impaired response of the nitric oxide system to CNP in spontaneously hypertensive rats (SHR) could affect vascular relaxation induced by the peptide in this model of hypertension, and that other endothelial systems or potassium channels opening could also be involved. We examined the effect of CNP on isolated SHR aortas, and the hindlimb vascular resistance (HVR) in response to CNP administration compared to normotensive rats...
2016: PloS One
Cedric Busschaert, Nicola D Ridgers, Ilse De Bourdeaudhuij, Greet Cardon, Jelle Van Cauwenberg, Katrien De Cocker
INTRODUCTION: More knowledge is warranted about multilevel ecological variables associated with context-specific sitting time among adolescents. The present study explored cross-sectional and longitudinal associations of ecological domains of sedentary behaviour, including socio-demographic, social-cognitive, health-related and physical-environmental variables with sitting during TV viewing, computer use, electronic gaming and motorized transport among adolescents. METHODS: For this longitudinal study, a sample of Belgian adolescents completed questionnaires at school on context-specific sitting time and associated ecological variables...
2016: PloS One
Lars E Olsson, Paul D Hockings
PURPOSE: The interest in measurements of magnetic resonance imaging relaxation times, T1, T2, T2*, with intention to characterize healthy and diseased lungs has increased recently. Animal studies play an important role in this context providing models for understanding and linking the measured relaxation time changes to the underlying physiology or disease. The aim of this work was to study how the measured transversal relaxation time (T2) in healthy lungs is affected by normal respiration in mouse...
2016: PloS One
Minke H T Hartman, Inge Vreeswijk-Baudoin, Hilde E Groot, Kees W A van de Kolk, Rudolf A de Boer, Irene Mateo Leach, Rozemarijn Vliegenthart, Herman H W Sillje, Pim van der Harst
BACKGROUND: Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R). METHODS: CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0...
2016: PloS One
Fábio H Silva, Mário A Claudino, Fabiano B Calmasini, Eduardo C Alexandre, Carla Franco-Penteado, Arthur L Burnett, Edson Antunes, Fernando F Costa
BACKGROUND: Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. OBJECTIVE: Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic machinery and nitric oxide-cyclic guanosine monophosphate signaling pathway in Townes transgenic sickle cell disease mice. METHODS: Concentration-response curves to contractile (phenylephrine) and relaxant agents (acetylcholine and sodium nitroprusside) were obtained in corpus cavernosum strips from sickle and C57BL/6 (control) mice...
2016: PloS One
Mi-Jin Jin, Seon Young Moon, Jungmin Park, Vijayakumar Modepalli, Junhyeon Jo, Shin-Ik Kim, Hyun Cheol Koo, Byoung-Chul Min, Hyun-Woo Lee, Seung-Hyub Baek, Jung-Woo Yoo
A two-dimensional electron gas emerged at a LaAlO3/SrTiO3 interface is an ideal system for "spin-orbitronics" as the structure itself strongly couple the spin and orbital degree of freedom through the Rashba spin-orbit interaction. One of core experiments toward this direction is the nonlocal spin transport measurement, which has remained elusive due to the low spin injection efficiency to this system. Here we bypass the problem by generating a spin current not through the spin injection from outside but instead through the inherent spin Hall effect and demonstrate the nonlocal spin transport...
December 9, 2016: Nano Letters
Manuel Salado, Jesus Idigoras, Laura Calio, Samrana Kazim, Mohammad Khaja Nazeeruddin, Juan A Anta, Shahzada Ahmad
Perovskite solar cells with variety of hole selective contacts such as 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD), poly(3-hexylthiophene-2,5-diyl), poly[bis(4-phenyl)(2,5,6-trimentlyphenyl)amine], 5,10,15-trihexyl-3,8,13-tris(4-methoxyphenyl)-10,15-dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole (HMPDI), and 2',7'-bis(bis(4-methoxyphenyl)amino)spiro[cyclopenta[2,1-b:3,4-b']dithiophene-4,9'-fluorene] were employed to elucidate its role at the interface of perovskite and metallic cathode...
December 9, 2016: ACS Applied Materials & Interfaces
Miroslav Radenkovic, Marko Stojanović, Ivana Milićević Nešić, Milica Prostran
The endothelium is one of the most important constituents of vascular homeostasis, which is achieved through continual and balanced production of different relaxing and contractile factors. When there is a pathological disturbance in release of these products, endothelial dysfunction (ED) will probably occur. ED is considered to be the initial step in the development of atherosclerosis. This pathological activation and inadequate functioning of endothelial cells was shown to be to some extent a reversible process, which all together resulted in increased interest in investigation of different beneficial treatment options...
August 2016: Indian Journal of Medical Research
Yoji Horii, Keiichi Katoh, Goulven Cosquer, Brian K Breedlove, Masahiro Yamashita
The Dy(III) quintuple-decker complex DyCdCdDy and hetero quadruple-decker complex DyCdY were synthesized, and their magnetic properties were compared with those of the quadruple-decker complex DyCdDy. Single-crystal X-ray analysis revealed that the coordination geometries around the Dy(III) ions of DyCdCdDy, DyCdY, and DyCdDy were similar. dc (direct current) magnetic measurements indicated that DyCdCdDy had very weak ferromagnetic Dy(III)-Dy(III) interactions but DyCdY did not. From a comparison of the magnetic relaxation times (τ) of the three complexes, the τ values of DyCdCdDy and DyCdDy, which have weak Dy(III)-Dy(III) interactions, are longer than that of DyCdY...
November 21, 2016: Inorganic Chemistry
Deb Pratim Mukhopadhyay, Souvick Biswas, Tapas Chakraborty
Laser-induced fluorescence (FE) and vibrationally resolved dispersed fluorescence (DF) spectra of a 1:1 water complex of p-fluorophenol (pFP) have been measured in a supersonic jet expansion. The hydrogen bond stretching fundamental (σ0(1)) of the complex appears in the FE spectrum as a doublet with band maxima at 155 and 161 cm(-1). Emission spectra recorded upon excitations of the two components reveal that a Fermi resonance between σ(1) and a combination involving a low-frequency intramolecular mode of pFP (mode 11) and a bending mode of water at the hydrogen bonded interface (mode ρ1) is responsible for the observed splitting...
November 23, 2016: Journal of Physical Chemistry. A
Diane Daube, Victoria Aladin, Jörg Heiliger, Johannes J Wittmann, Dominic Barthelmes, Christian Bengs, Harald Schwalbe, Björn Corzilius
We report on the spontaneous polarization transfer from dynamically hyperpolarized (1)H to (13)C during magic-angle spinning (MAS) dynamic nuclear polarization (DNP) at temperatures around 100 K. The transfer is mediated by (1)H-(13)C cross-relaxation (CR) within methyl groups due to reorientation dynamics, and results in an inverted (13)C-NMR signal of enhanced amplitude. Further spreading of transferred polarization can then occur via (13)C-(13)C spin-diffusion. The resulting process is equal to the nuclear Overhauser effect (NOE) where typically continuous saturation of (1)H by radio frequency irradiation is employed...
December 9, 2016: Journal of the American Chemical Society
Kamoladdin Egamberdiev, Sirojiddin Z Mirzaev, Udo Kaatze
The diffusion coefficients and shear viscosities of 2,6-dimethylpyridine-water mixtures of critical composition have been measured without and with small amounts of alkali halides added. The data have been analyzed in terms of power law behavior. Deviations from power law behavior indicate a coupling between the critical fluctuations in the local concentrations and the formation of mesoscopic molecular aggregates. The critical exponent of the fluctuation correlation length, the shear viscosity exponent, and the critical exponent of the relaxation rate of fluctuations have been evaluated to show noticeable influences from the salts...
December 8, 2016: Journal of Physical Chemistry. B
Sukanya Bhattacharya, Dharmendar Kumar Sharma, Suman De, Jaladhar Mahato, Arindam Chowdhury
While dynamics of single-molecule (SM) fluorescent probes have been used to investigate the structure and relaxation processes in polymers near the glass transition temperature (Tg), it is difficult to perform SM imaging at elevated temperatures which restricts such studies to a limited number of polymers for which Tg is close to room temperature (RT). Plasticization, solvent (or additive) induced lowering of Tg, offers an alternate avenue to access various effective temperatures in the glassy and rubbery phases of polymers under ambient conditions...
December 8, 2016: Journal of Physical Chemistry. B
Chih-Chung Chiu, Chih-Chang Hung, Po-Yuan Cheng
The charge-transfer (CT) state relaxation dynamics of the binary (1:1) and ternary (2:1) benzene/tetracyanoethylene (BZ/TCNE) complexes are reported. Steady-state and ultrafast time-resolved broadband fluorescence (TRFL) spectra of TCNE dissolved in a series of BZ/CCl4 mixed solvents are measured to elucidate the spectroscopic properties of the BZ/TCNE complexes and their CT-state relaxation dynamics. Both steady-state and TRFL spectra exhibit marked BZ concentration dependences, which can be attributed to the formation of two types of 2:1 complexes in the ground and excited states...
December 8, 2016: Journal of Physical Chemistry. B
Atsushi Beniya, Hirohito Hirata, Yoshihide Watanabe
Relaxation dynamics of hot metal clusters on oxide surfaces play a crucial role in a variety of physical and chemical processes. However, their transient mobility has not been investigated as much as other systems such as atoms and molecules on metal surfaces due to experimental difficulties. To study the role of the transient mobility of clusters on the oxide surface, we investigated the initial adsorption process of size-selected Pt clusters on a thin Al2O3 film. Soft-landing the size-selected clusters while suppressing the thermal migration resulted in the transient migration controlling the initial adsorption states as an isolated and aggregated cluster, as revealed using scanning tunneling microscopy...
November 17, 2016: Journal of Physical Chemistry Letters
Mengmeng Zheng, Yuqi Wang, Hua Shi, Yuxuan Hu, Liandong Feng, Zhiliang Luo, Mi Zhou, Jian He, Zhenyang Zhou, Yan Zhang, Deju Ye
Activatable multimodal probes that show enhancement of multiplex imaging signals upon interaction with their specific molecular target have become powerful tools for rapid and precise imaging of biological processes. Herein, we report a stimuli-responsive disassembly approach to construct a redox-activatable fluorescence/(19)F-MRS/(1)H-MRI triple-functional probe 1. The small molecule probe 1 itself has a high propensity to self-assemble into nanoparticles with quenched fluorescence, attenuated (19)F-MRS signal, and high (1)H-MRI contrast...
November 22, 2016: ACS Nano
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