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https://www.readbyqxmd.com/read/29156097/4-aminopyridine-a-pan-kv-channel-inhibitor-that-enhances-kv7-4-currents-and-inhibits-noradrenaline-mediated-contraction-of-rat-mesenteric-small-arteries
#1
Makhala M Khammy, Sukhan Kim, Bo H Bentzen, Soojung Lee, Inyeoung Choi, Christian Aalkjaer, Thomas A Jepps
BACKGROUND AND PURPOSE: Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4-aminopyridine (4-AP) is considered a broad inhibitor of voltage-gated potassium (KV ) channels, with little inhibitory effect on Kv7 family members at millimolar concentrations. However, the effect of 4-AP on Kv7 channels has not been systematically studied. The aim of this study was to investigate the pharmacological activity of 4-AP on Kv7.4 and Kv7.5 channels and characterise the effect of 4-AP on rat resistance arteries...
November 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29155822/heavy-atom-effect-on-optically-excited-triplet-state-kinetics
#2
Christian Hintze, Tobias O Morgen, Malte Drescher
In several fields of research, like e.g. photosensitization, photovoltaics, organic electroluminescent devices, dynamic nuclear polarization, or pulsed dipolar electron paramagnetic resonance spectroscopy, triplet state kinetics play an important role. It is therefore desirable to tailor the kinetics of photoexcited triplet states, e.g. by exploiting the intramolecular heavy-atom effect, and to determine the respective kinetic parameters. In this work, we set out to systematically investigate the photoexcited triplet state kinetics of a series of haloanthracenes by time-resolved electron paramagnetic resonance spectroscopy in combination with synchronized laser excitation...
2017: PloS One
https://www.readbyqxmd.com/read/29155588/determination-of-equilibrium-constant-and-relative-brightness-in-fret-fcs-by-including-the-third-order-correlations
#3
Lingyi Meng, Shanshan He, Xin Sheng Zhao
Fluorescence correlation spectroscopy (FCS) encodes the information of the equilibrium constant (K), the relative fluorescence brightness of fluorophore (Q), and the forward and backward reaction rate constants (k+ and k-) on a physical or chemical relaxation. However, it has been a long-standing problem to completely resolve the FCS data to get the thermodynamic and kinetic information. Recently, we have solved the problem for fluorescence auto-correlation spectroscopy (FACS). Here, we extend the method to fluorescence cross-correlation spectroscopy (FCCS), which appears when FCS is coupled with fluorescence resonance energy transfer (FRET)...
November 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29155298/mechanisms-of-l-alpha-lysophosphatidylinositol-induced-relaxation-in-human-pulmonary-arteries
#4
Olga Karpińska, Marta Baranowska-Kuczko, Barbara Malinowska, Monika Kloza, Magdalena Kusaczuk, Agnieszka Gęgotek, Paweł Golec, Irena Kasacka, Hanna Kozłowska
AIMS: l-Alpha-lysophosphatidylinositol (LPI) is an endogenous agonist of G protein-coupled receptor 55 (GPR55) which relaxes mesenteric arteries on activation. The aim of the present study was to determine the influence and underlying mechanisms of LPI-induced relaxation in human pulmonary arteries (hPAs). MAIN METHODS: Functional studies were performed in isolated hPAs using organ bath technique. The expression of GPR55 in hPAs and bronchioles was determined by real-time qPCR, Western blot analysis, and immunohistochemistry...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29155199/physiochemical-and-functional-properties-of-tiger-puffer-takifugu-rubripes-skin-gelatin-as-affected-by-extraction-conditions
#5
Jinfeng Pan, Qi Li, Hui Jia, Lining Xia, Wengang Jin, Meijun Shang, Chang Xu, Xiuping Dong
The study investigated physiochemical and functional properties of gelatins from tiger puffer skin (GTPS) extracted with warm-water method at 45, 55 and 65°C for 3, 6 and 12h. GTPS45 exhibited strong γ-, β-, α1- and α2-chains, but they faded with the presence of fragments (<80 KDa) in other GTPS. As the increase of temperature and time, amide I and A were shifted to higher wavenumber and their amplitudes in GTPS65-12 decreased. Lightness declined while redness and yellowness were enhanced. Gel strength was in a range of 144...
November 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29155072/a-protocol-to-study-ex-vivo-mouse-working-heart-at-human-like-heart-rate
#6
Han-Zhong Feng, Jian-Ping Jin
Genetically modified mice are widely used as experimental models to study human heart function and diseases. However, the fast rate of normal mouse heart at 400-600bpm limits its capacity of assessing kinetic parameters that are important for the physiology and pathophysiology of human heart that beats at a much slower rate (75-180bpm). To extend the value of mouse models, we established a protocol to study ex vivo mouse working hearts at a human-like heart rate. In the presence of 300μM lidocaine to lower pacemaker and conductive activities and prevent arrhythmia, a stable rate of 120-130bpm at 37°C is achieved for ex vivo mouse working hearts...
November 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29154916/acute-intravenous-exposure-to-silver-nanoparticles-during-pregnancy-induces-particle-size-and-vehicle-dependent-changes-in-vascular-tissue-contractility-in-sprague-dawley-rats
#7
A K Vidanapathirana, L C Thompson, M Herco, J Odom, S J Sumner, T R Fennell, J M Brown, C J Wingard
The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110nm AgNP (700μg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24hours post-exposure...
November 14, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29154805/the-effects-of-imaginary-voluntary-muscle-contraction-and-relaxation-on-cerebellar-brain-inhibition
#8
Hiroaki Tanaka, Akiyoshi Matsugi, Yohei Okada
The purpose of this study was to investigate cerebellar brain inhibition (CBI) of the contralateral primary motor cortex (M1) during imaginary muscle contraction (Contract-I) and relaxation (Relax-I) using transcranial magnetic stimulation (TMS). Twenty-nine healthy adults completed two experiments. Motor evoked potentials (MEPs) in the right first dorsal interosseous (FDI) muscle were induced by TMS over the left M1 and measured with or without TMS over the right cerebellum during Contract-I (first experiment) and Relax-I (second experiment) of the right FDI, and these were compared to the findings in a no-imagery (No-I) condition...
November 14, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29154801/human-small-bowel-as-a-useful-tool-to-investigate-smooth-muscle-effects-of-potential-therapeutics-in-organophosphate-poisoning
#9
Katharina Marquart, Olga Prokopchuk, Franz Worek, Horst Thiermann, Marc E Martignoni, Timo Wille
Isolated organs proofed to be a robust tool to study effects of (potential) therapeutics in organophosphate poisoning. Small bowel samples have been successfully used to reveal smooth muscle relaxing effects. In the present study, the effects of obidoxime, TMB-4, HI-6 and MB 327 were investigated on human small bowel tissue and compared with rat data. Hereby, the substances were tested in at least seven different concentrations in the jejunum or ileum both pre-contracted with carbamoylcholine. Additionally, the cholinesterase activity of native tissue was determined...
November 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29154798/non-pharmacological-interventions-for-reducing-mental-distress-in-patients-undergoing-dental-procedures-systematic-review-and-meta-analysis
#10
REVIEW
Sophia Burghardt, Susan Koranyi, Gabriel Magnucki, Bernhard Strauss, Jenny Rosendahl
OBJECTIVES: This meta-analysis investigates the efficacy of non-pharmacological interventions in adults undergoing dental procedures under regional or general anesthesia compared to standard care alone or an attention control group on the reduction of mental distress, pain, and analgesic use. DATA SOURCES: To identify relevant papers a comprehensive literature search was carried out in MEDLINE, CENTRAL, Web of Science, and PsycINFO (last search August, 2017). Additionally, lists of references of relevant articles and previous reviews were checked...
November 14, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29154533/voltage-assisted-magnetic-switching-in-mgo-cofeb-based-magnetic-tunnel-junctions-by-way-of-interface-reconstruction
#11
Jungho Ko, Jongill Hong
Engineering of interfacial structures has become important more than ever before to find new scientific observations and to create novel applications. Here, we show that the interface reconstructed by atomic layer-thick Mg insertion substantially improved the magneto-electrical properties of perpendicular magnetic tunnel junctions essential for modern spintronic applications. The 0.2-0.4 nm-thick Mg inserted between the MgO tunnel barrier and CoFeB ferromagnet restructured the interface in such ways as to protect the CoFeB from overoxidation, to strengthen the texture, to make the interfacial roughness smooth, and to relax the mechanical stress...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29154072/physiological-effects-of-viewing-fresh-red-roses
#12
Chorong Song, Miho Igarashi, Harumi Ikei, Yoshifumi Miyazaki
OBJECTIVES: The present study aimed to clarify the effects of viewing fresh roses on prefrontal cortex activity, autonomic nervous activity and subjective assessments of psychological relaxation. DESIGN: A crossover design, in which each experimental group crosses over from one treatment to another, was used. SETTING AND INTERVENTIONS: A total of 15 female university students (mean age 21.7±1.1years) viewed fresh roses for 3min; the control consisted of no experimental stimulus...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29154070/complementary-and-alternative-therapies-in-dentistry-and-characteristics-of-dentists-who-recommend-them
#13
Beatrice Baatsch, Stefan Zimmer, Daniela Rodrigues Recchia, Arndt Büssing
OBJECTIVES: The aims of this study were to analyse whether dentists offer or recommend complementary and alternative medicine (CAM) remedies in their clinical routine, and how effective these are rated by proponents and opponents. A second aim of this study was to give a profile of the dentists endorsing CAM. DESIGN: A prospective, explorative, anonymised cross-sectional survey was spread among practicing dentists in Germany via congresses, dental periodicals and online (n=250, 55% male, 45% female; mean age 49...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29154068/yoga-s-effect-on-falls-in-rural-older-adults
#14
Irene Hamrick, Paul Mross, Nate Christopher, Paul D Smith
BACKGROUND: Unintentional falls affect 30% of people over age 65 years. Yoga has been shown to improve balance. We designed this study to examine if yoga reduces falls. METHODS: We conducted 16 sessions of Hatha yoga over 8 weeks. Participants were randomly assigned to practice 10min of yoga daily at home in addition to 5-min relaxation exercises or relaxation exercises only (control group). RESULTS: Of the 38 participants completing the intervention, 15 participants reported a total of 27 falls in the 6-months before the study, compared to 13 participants sustaining 14 falls in the 6 months from the start of the study (p<0...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29153711/characterisation-of-heterogeneity-and-spatial-autocorrelation-in-phase-separating-mixtures-using-moran-s-i
#15
Emma S Thompson, Pieter Saveyn, Marc Declercq, Joris Meert, Vincenzo Guida, Charles D Eads, Eric S J Robles, Melanie M Britton
In complex colloidal systems, particle-poor regions can develop within particle-rich phases during sedimentation or creaming. These particle-poor regions are overlooked by 1D profiles, which are typically used to assess particle distributions in a sample. Alternative methods to visualise and quantify these regions are required to better understand phase separation, which is the focus of this paper. Magnetic resonance imaging has been used to monitor the development of compositional heterogeneity in a vesicle-polymer mixture undergoing creaming...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153707/the-influence-of-muscle-activation-on-impact-dynamics-during-lateral-falls-on-the-hip
#16
Daniel R Martel, Iris C Levine, Steven P Pretty, Andrew C Laing
Muscle activation has been demonstrated to influence impact dynamics during scenarios including running, automotive impacts, and head impacts. This study investigated the effects of targeted muscle activation magnitude on impact dynamics during low energy falls on the hip with human volunteers. Fifteen university-aged participants (eight females, seven males) underwent 12 lateral pelvis release trials. Half of the trials were muscle-'relaxed'; in the remaining 'contracted' trials participants isometrically contracted their gluteus medius to 20-30% of maximal voluntary contraction before the drop was initiated onto a force plate...
November 10, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29153562/noncontrast-myocardial-t1-mapping-by-cardiac-magnetic-resonance-predicts-outcome-in-patients-with-aortic-stenosis
#17
Heesun Lee, Jun-Bean Park, Yeonyee E Yoon, Eun-Ah Park, Hyung-Kwan Kim, Whal Lee, Yong-Jin Kim, Goo-Yeong Cho, Dae-Won Sohn, Andreas Greiser, Seung-Pyo Lee
OBJECTIVES: The aim of this study was to evaluate whether native T1 value of the myocardium on cardiac magnetic resonance (CMR) could predict clinical events in patients with significant aortic stenosis (AS). BACKGROUND: Although previous studies have demonstrated the prognostic value of focal fibrosis using late gadolinium enhancement (LGE) by CMR in AS patients, the prognostic implication of diffuse myocardial fibrosis by noninvasive imaging remains unknown. METHODS: A prospective observational longitudinal study was performed in 127 consecutive patients with moderate or severe AS (68...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29153442/functional-mri-study-to-examine-possible-emotional-connectedness-in-identical-twins-a-case-study
#18
Efstratios Karavasilis, Foteini Christidi, Kalliopi Platoni, Panagiotis Ferentinos, Nikolaos L Kelekis, Efstathios P Efstathopoulos
In the present case study, we investigated possible emotional connectedness between monozygotic twins by means of functional magnetic resonance imaging (fMRI). During the experimental condition, Twin 2 was randomly selected to participate in the neuroimaging protocol while Twin 1 participated in the experimental condition outside the MRI scanner (none of them was aware of the experimental procedure). The experimental condition included two sessions with visual and acoustic stimuli, respectively. Between the two experimental conditions, there was a 2-min break with Twin 1 (i...
October 23, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29152974/biocompatible-copper-oxide-nanoparticle-composites-from-cellulose-and-chitosan-facile-synthesis-unique-structure-and-antimicrobial-activity
#19
Chieu D Tran, James Makuvaza, Erik Munson, Brian Bennett
Copper in various forms has been known to have bactericidal activity. Challenges to its application include preventing mobilization of the copper, to both extend activity and avoid toxicity, and bioincompatibility of many candidate substrates for copper-immobilization. Using a simple ionic liquid, butylmethylimmidazolium chloride as the solvent, we developed a facile and green method to synthesize biocompatible composites containing copper oxide nanoparticles (CuONPs) from cellulose (CEL) and chitosan (CS) or CEL and keratin (KER)...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29152524/young-adult-perceptions-surrounding-hookah-use
#20
Megan E Roberts, Elizabeth G Klein, Micah L Berman, Bilen Berhane, Amy K Ferketich
Objective: We aimed to improve understanding of young adults' perceptions and interpretations of the contexts surrounding use. Methods: We conducted focus groups with young adult hookah users (ages 18-28) to examine hookah-use experiences and risk perceptions. Results: Two dominant themes that emerged from the discussions were the social aspects of use (eg, "ending up" at a hookah café while out with friends), and the mental and physiological reactions to use (eg, relaxation and a "high" feeling)...
November 2017: Health Behavior and Policy Review
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